JOHANNA LAAKKONEN

Yhteystiedot

Avainsanat

Tutkimusryhmät - UEF

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  GeneCellNano-lippulaiva
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  Molekulaarinen lääketiede
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  Verisuonibiologian tutkimusryhmä (Laakkonen)

Linkit

• Research gate researchgate.net/profile/Johanna_Laakkonen

Julkaisut

• Keränen, Sara; Suutarinen, Santeri; Mallick, Rahul; Laakkonen, Johanna P.; Guo, Diana; Pawlikowska, Ludmila; Jahromi, Behnam Rezai; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; Marchuk, Doug; Krings, Timo; Koivisto, Timo; Lawton, Michael; Radovanovic, Ivan; Kim, Helen; Faughnan, Marie E.; Frösen, Juhana. 2021. Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation Acta neurochirurgica 163 9: 2503-2514. 2021
• Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. 2021. Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types Arteriosclerosis, thrombosis, and vascular biology 41 7: 2149-2167. 2021
• Mushimiyimana, I; Niskanen. H; Beter, M; Laakkonen, JP; Kaikkonen, MU; Ylä-Herttuala, S; Laham-Karam, N. 2021. Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis Nucleic acids research 49 14: 8078-8096. 2021
• Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death Biomolecules 11 3: 452. 2021
• Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia. Laakkonen, Johanna P; Ylä-Herttuala, Seppo / Emerging Technologies for Heart Diseases. Volume 2: Treatments for Myocardial Ischemia and Arrhythmias. 2020. 2020
• Hsin-Fu Liu, Oscar; Kiema, Miika; Beter, Mustafa; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Kaikkonen, Minna U. 2020. Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells Arteriosclerosis thrombosis and vascular biology 40: 2665-2677. 2020
• Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P. 2020. BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF Angiogenesis 2021; 24 1: 12-144. 2020
• Jauhiainen, Suvi; Laakkonen, Johanna P; Ketola, Kirsi; Toivanen, Pyry, I; Nieminen, Tina; Ninchoji, Takeshi; Levonen, Anna-Liisa; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. 2019. Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function Frontiers in physiology 10: 224. 2019
• Laakkonen, Johanna P; Lähteenvuo, Johanna; Jauhiainen, Suvi; Heikura, Tommi; Ylä-Herttuala, Seppo. 2019. Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta Vascular pharmacology 112: 91-101. 2019
• Soikkeli, Maiju; Kettunen, Mikko I; Nivajärvi, Riikka; Olsson, Venla; Rönkkö, Seppo; Laakkonen, Johanna P; Lehto, Vesa-Pekka; Kavakka, Jari; Heikkinen, Sami. 2019. Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging Contrast media and molecular imaging 2019: 5629597. 2019
• Vuorio, Taina; Ylä-Herttuala, Elias; Laakkonen, Johanna P; Laidinen, Svetlana; Liimatainen, Timo; Ylä-Herttuala, Seppo. 2018. Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction Scientific Reports 8: 16709. 2018
• Aoki Tomohiro, Frösen Juhana, Fukuda Miyuki, Bando Kana, Shioi Go, Tsuji Keiichi, Ollikainen Eliisa, Nozaki Kazuhiko, Laakkonen Johanna, Narumiya Shuh. 2017. Prostaglandin E2-EP2-NF-kB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Science signaling 10 465: eaah6037. 2017
• Toivanen Pyry I, Nieminen Tiina, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Ylä-Herttuala Seppo. 2017. Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling. Scientific Reports 7: 5525. 2017
• Laakkonen Johanna P, Lappalainen Jari P, Theelen Thomas L, Toivanen Pyry I, Nieminen Tiina, Jauhiainen Suvi,Kaikkonen Minna U, Sluimer Judith C, Ylä-Herttuala Seppo. 2016. Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8. Angiogenesis [Epub ahead of print 21 Nov 2016]: 1-16. 2016
• Laakkonen Johanna P, Ylä-Herttuala Seppo. 2016. Animal Models of Gene Therapy for Cardiovascular Disease. Teoksessa: David T. Curiel (toim.) Adenoviral Vectors for Gene Therapy. Elsevier. s. 691-705. 2016
• Laakkonen Johanna P., Ylä-Herttuala Seppo. 2015. Recent Advancements in Cardiovascular Gene Therapy and Vascular Biology. HUMAN GENE THERAPY 26 8: 518-524. 2015
• Nieminen Tiina, Toivanen Pyry I, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Airenne Kari J, Ylä-Herttuala Seppo. 2015. Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity. CARDIOVASCULAR RESEARCH 107 2: 267-276. 2015
• Turunen Mikko P, Husso Tiia, Musthafa Haja, Laidinen Svetlana, Dragneva Galina, Laham-Karam Nihay, Honkanen Sanna, Paakinaho Anne, Laakkonen Johanna P, Gao Erhe, Vihinen-Ranta Maija, Liimatainen Timo, Ylä-Herttuala Seppo. 2014. Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice. PLOS ONE [ONLINE] 2014 Feb 26;9(2):e89979: e89979. 2014