Johanna Laakkonen
Academy Research Fellow
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
[email protected] | +358 50 305 8453
I’m an Academy Research Fellow, and PI of a junior research group focusing on Vascular Biology. The goal of our team is to improve therapeutics and diagnostics of cardiovascular diseases by understanding the biology behind the diseases. The main focus is in studying vascular anomalies and aortic aneurysms. Particularly genetics, cell-cell interaction and angioparacrine mediators are studied.
Research groups
-
Molecular Medicine 01.01.1995 - -
Heart surgery imaging 01.01.2022 - -
Vascular Biology (Laakkonen) 01.09.2019 -
Projects
Publications
36/36 items-
Cell-Specific Targeting of the Endothelium in the CardioRenal Syndrome
Laham-Karam, Nihay; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Aroor, Annayya; Jia, Guanghong; Whaley-Connell, Adam. 2024. Cardiorenal medicine. 14: 129–135 A2 Review article, Literature review, Systematic review -
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro
Selvarajan, Ilakya; Kiema, Miika; Huang, Ru Ting; Li, Jin; Zhu, Jiayu; Pölönen, Petri; Örd, Tiit; Õunap, Kadri; Godiwala, Mehvash; Golebiewski, Anna Kathryn; Ravindran, Aarthi; Mäklin, Kiira; Toropainen, Anu; Stolze, Lindsey K; Arce, Maximiliano; Magnusson, Peetra U; White, Stephen; Romanoski, Casey E; Heinäniemi, Merja; Laakkonen, Johanna P; Fang, Yun; Kaikkonen, Minna U. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 1330-1345 A1 Journal article (refereed), original research -
Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart
Järveläinen, Niko; Halonen, Paavo J; Nurro, Jussi; Kuivanen, Antti; Pajula, Juho; Tarkia, Miikka; Grönman, Maria; Saraste, Antti; Laakkonen, Johanna; Toivanen, Pyry; Nieminen, Tiina; Rissanen, Tuomas T; Knuuti, Juhani; Ylä-Herttuala, Seppo. 2024. Scientific reports. 14: . 30003 A1 Journal article (refereed), original research -
Proteomics on human cerebral cavernous malformations reveals novel biomarkers in neurovascular dysfunction for the disease pathology
Jauhiainen, Suvi; Onyeogaziri, Favour C; Lazzaroni, Francesca; Conze, Lei Liu; Laakkonen, Johanna P.; Karam, Nihay Laham; Laakso, Aki; Niemelä, Mika; Jahromi, Behnam Rezai; Magnusson, Peetra U.. 2024. Biochimica et biophysica acta: molecular basis of disease. 1870: A1 Journal article (refereed), original research -
The mineralocorticoid receptor in diabetic kidney disease
Jia, Guanghong; Lastra, Guido; Bostick, Brian P; LahamKaram, Nihay; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Whaley-Connell, Adam. 2024. American journal of physiology-renal physiology. 327: F519-F531 A2 Review article, Literature review, Systematic review -
Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis
Ravindran, Aarthi; Holappa, Lari; Niskanen, Henri; Skovorodkin, Ilya; Kaisto, Susanna; Beter, Mustafa; Kiema, Miika; Selvarajan, Ilakya; Nurminen, Valtteri; Aavik, Einari; Aherrahrou, Rédouane; Pasonen-Seppänen, Sanna; Fortino, Vittorio; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Vainio, Seppo; Örd, Tiit; Kaikkonen, Minna U. 2024. Cardiovascular research. 120: 869-882 A1 Journal article (refereed), original research -
BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium
Pulkkinen, HH; Kivistö-Rahnasto, A; Korpela, H; Heikkilä, M; Järveläinen, N; Siimes, S; Kilpeläinen, L; Laham-Karam, N; Ylä-Herttuala, S; Laakkonen, JP. 2023. Frontiers in cardiovascular medicine. 10: . 1279613 A1 Journal article (refereed), original research -
Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia
Wirth, Galina; Juusola, Greta; Tarvainen, Santeri; Laakkonen, Johanna P.; Korpisalo, Petra; Ylä-Herttuala, Seppo. 2023. Cells. 12: A1 Journal article (refereed), original research -
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures
Örd, Tiit; Lönnberg, Tapio; Nurminen, Valtteri; Ravindran, Aarthi; Niskanen, Henri; Kiema, Miika; Õunap, Kadri; Maria, Maleeha; Moreau, Pierre R; Mishra, Pashupati P; Palani, Senthil; Virta, Jenni; Liljenbäck, Heidi; Aavik, Einari; Roivainen, Anne; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Lehtimäki, Terho; Kaikkonen, Minna U. 2023. American journal of human genetics. 110: 722-740 A1 Journal article (refereed), original research -
ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component
Jauhiainen, Suvi; Ilmonen, Henna; Vuola, Pia; Rasinkangas, Heta; Pulkkinen, Heidi H; Keränen, Sara; Kiema, Miika; Liikkanen, Jade J; Laham Karam, Nihay; Laidinen, Svetlana; Beter, Mustafa; Aavik, Einari; Lappalainen, Kimmo; Lohi, Jouko; Aronniemi, Johanna; Örd, Tiit; Kaikkonen, Minna U; Salminen, Päivi; Tukiainen, Erkki; Ylä-Herttuala, Seppo; Laakkonen, Johanna P. 2023. eLife. 12: A1 Journal article (refereed), original research