JOUKO VEPSäLäINEN

Yhteystiedot

TUTKIMUSRYHMÄT - UEF

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  Biojalostus
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  Mikromuovit ja terveys
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  Mikromuovitutkimus
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  Soveltava kemia
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  Vesitutkimus

Julkaisut

• Hagner, Marleena; Räty, Mari; Nikama, Johanna; Rasa, Kimmo; Peltonen, Sari; Vepsäläinen, Jouko; Keskinen, Riikka. 2021. Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms Science of the total environment 784: 147139. 2021
• Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. [alfa]-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation Biomolecules 11 5: 707. 2021
• Kuittinen, Suvi; Hietaharju, Jenna; Kupiainen, Laura; Hassan, Md. Kamrul; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Kangas, Jani; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari. 2021. Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture Journal of cleaner production 293: 126088. 2021
• Salami, Ayobami; Heikkinen, Jorma; Tomppo, Laura; Hyttinen, Marko; Kekäläinen, Timo; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo. 2021. A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots Molecules 26 11: 3167. 2021
• Thapa, Rinez; Rahmani, Arezoo; Turhanen, Petri; Taskinen, Antti; Nissinen, Tuomo; Neitola, Raisa; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim. 2021. Recovery of uranium with bisphosphonate modified mesoporous silicon Separation and purification technology 272: 118913. 2021
• Verkasalo, Erkki; Möttönen, Veikko; Roitto, Marja; Vepsäläinen, Jouko; Kumar, Anuj; Ilvesniemi, Hannu; Siwale, Workson; Julkunen-Tiitto, Riitta; Raatikainen, Olavi; Sikanen, Lauri. 2021. Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds Forests 12 2: 192. 2021
• Haluska, Ondřej; Rahmani, Arezoo; Salami, Ayobami; Turhanen, Petri; Vepsäläinen, Jouko; Lappalainen, Reijo; Lehto, Vesa-Pekka; Riikonen, Joakim. 2021. Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption Microporous and mesoporous materials 324: 111294. 2021
• Salami, A; Vilppo, T; Pitkänen, S; Weisell, J; Raninen, K; Vepsäläinen, J; Lappalainen, R. 2020. Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process Scientific African 8: 1-13. 2020
• Szlachta, Malgorzata; Neitola, Raisa; Peräniemi, Sirpa; Vepsäläinen, Jouko. 2020. Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent Separation and purification technology 253: 117493. 2020
• Sandar, Sandra; Yang, Ming; Turunen, Ossi; Vepsäläinen, Jouko; Pappinen, Ari; Kuittinen, Suvi. 2020. Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams Bioresources 15 4: 9265-9290. 2020
• Salami, Ayobami; Raninen, Kaisa; Heikkinen, Jorma; Tomppo, Laura; Vilppo, Teemu; Selenius, Mikko; Raatikainen, Olavi; Lappalainen, Reijo; Vepsäläinen, Jouko. 2020. Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing Industrial crops and products 155: 112760. 2020
• Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules 10 3: 406. 2020
• Riikonen, Joakim; Rantanen, Jimi; Thapa, Rinez; Le, Nguyen T; Rigolet, Severinne; Fioux, Philippe; Turhanen, Petri; Bodiford, Nelli K; Kalluri, Jhansi R; lkonen, Timo; Nissinen, Tuomo; Lebeau, Benedicte; Vepsäläinen, Jouko; Coffer, Jeffery L; Lehto, Vesa-Pekka. 2020. Rapid synthesis of nanostructured porous silicon carbide from biogenic silica Journal of the American Ceramic Society 2021; 104 2: 766-775. 2020
• Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR. 2020. Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine Russian journal of bioorganic chemistry 46 6: 686-692. 2020
• Hagner, Marleena; Lindqvist, Bengt; Vepsäläinen, Jouko; Samorì, Chiara; Keskinen, Riikka; Rasa, Kimmo; Hyvönen, Terho. 2020. Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum Environmental technology and innovation 20: 101154. 2020
• De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsäläinen, Jouko; Khomutov, Alex. 2020. Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group Communications chemistry 3 1: 121. 2020
• Turhanen, Petri; Leppänen, Jukka; Vepsäläinen, Jouko J. 2019. Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach ACS omega 4 5: 8974-8984. 2019
• Yang, Ming; Wang, Jia; Nan, Yufei; Zhang, Junhua; Li, Liyun; Liu, Guozhen; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari. 2019. Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation Rsc advances 9 58: 33755-33760. 2019
• Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M. 2019. Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics International journal of epidemiology 48 3: 978-993. 2019
• Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti. Turunen, Kaisa; Antikainen, Eero; Huotari-Halkosaari, Taija; Ikonen, Jenni; Janhunen, Maarit; Lahtinen, Tatu; Lerssi, Jouni; Miettinen, Ilkka; Meriläinen, Päivi; Niittynen, Marjo; Pullinen, Arto; Reijonen, Tero; Raatikainen, Mika; Sonninen, Jari; Torvinen, Olli; Vauhkonen, Marko; Vepsäläinen, Jouko. 2019 2019
• Thapa, Rinez; Nissinen, Tuomo; Turhanen, Petri; Määttä, Juha; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim. 2019. Bisphosphonate modified mesoporous silicon for scandium adsorption Microporous and mesoporous materials 2020; 296: 109980. 2019
• Mohsin, Muhammad; Kuittinen, Suvi; Abdus Salam, Mir Md; Peräniemi, Sirpa; Laine, Saila; Pulkkinen, Pertti; Kaipiainen, Erik; Vepsäläinen, Jouko; Pappinen, Ari. 2019. Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils Journal of geochemical exploration 205: 106335. 2019
• Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives Journal of medicinal chemistry 62 24: 11335-11347. 2019
• Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators Bioscience reports 38 4: BSR20180527. 2018
• Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase MENDELEEV COMMUNICATIONS 28 5: 479-481. 2018
• Kuittinen, Suvi; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari. 2018. Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf Bioresources 13 3: 5225-5240. 2018
• Lehtovirta, L; Reito, A; Parkkinen, J; Peräniemi, S; Vepsäläinen, J; Eskelinen, A. 2018. Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement PLOS ONE 13 5: e0197614. 2018
• Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration BIOCHEMICAL JOURNAL 475 3: 663-676. 2018
• Venäläinen, Markus K; Roine, Antti N; Häkkinen, Merja R; Vepsäläinen, Jouko J; Kumpulainen, Pekka S; Kiviniemi, Mikko S; Lehtimäki, Terho; Oksala, Niku K; Rantanen, Tuomo K. 2018. Altered polyamine profiles in colorectal cancer ANTICANCER RESEARCH 38 6: 3601-3607. 2018
• Yang, Ming; Xu, Minyuan; Nan, Yufei; Kuittinen, Suvi; Hassan, Md Kamrul; Vepsäläinen, Jouko; Xin, Donglin; Zhang, Junhua; Pappinen, Ari. 2018. Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production. BIORESOURCE TECHNOLOGY 257: 113-120. 2018
• Khomich OA, Yanvarev DV, Novikov RA, Kornev AB, Puljulla E, Vepsäläinen J, Khomutov AR, Kochetkov SN. 2017. On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge. MOLECULES 22 7: e1040. 2017
• Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U. 2017. Urinary Polyamines as Biomarkers for Ovarian Cancer. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 27 7: 1360-1366. 2017
• Yang Ming, Kuittinen Suvi, Vepsäläinen Jouko, Zhang Junhua, Pappinen Ari. 2017. Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement. BIORESOURCE TECHNOLOGY 243: 126-134. 2017
• Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN. 2016. Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase. Data in Brief 8: 1157-1167. 2016
• Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN. 2016. Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity. BIOCHIMIE 127: 153-162. 2016
• Turhanen Petri, Vepsäläinen Jouko. 2016. Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach. RSC Advances 6: 15937-15940. 2016
• Puljula Elina, Vepsäläinen Jouko, Turhanen Petri. 2016. Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 12: 2145-2149. 2016
• Khomutov MA, Simonian AR, Weisell J, Vepsäläinen J, Kochetkov SN. 2016. Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 42 4: 415-422. 2016
• Khomutov MA, Formanovsky AA, Mikhura IV, Vepsäläinen Jouko, Kochetkov SN, De Biase D, Khomutov AR. 2016. Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 42 6: 672-676. 2016
• Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation. BIOCHEMICAL JOURNAL 473 10: 1433-1441. 2016
• Turhanen Petri, Vepsäläinen Jouko. 2015. A powerful tool for acid catalyzed organic addition and substitution reactions. RSC Advances 5: 26218-26222. 2015
• Yang Ming, Zhang Junhua, Kuittinen Suvi, Vepsäläinen Jouko, Soininen Pasi, Keinänen Markku, Pappinen Ari. 2015. Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation. BIORESOURCE TECHNOLOGY 189: 131-137. 2015
• Weisell Janne, Vepsäläinen Jouko, Turhanen Petri A. 2015. Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 11: 2189-2193. 2015
• Vepsäläinen Jouko, Turhanen Petri. 2015. Uusi menetelmä ja uusi katalyyttinen järjestelmä selektiivisiin orgaanisiin additio- ja substituutioreaktioihin. FI20136328 (hakemusnro). Suomi. 2015
• Ucal Sebahat, Khomutov Alex R, Häkkinen Merja R, Turhanen Petri A, Vepsäläinen Jouko J, Weisell Janne. 2015. Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives. ARKIVOC 2015 7: 42-49. 2015
• Turhanen Petri A, Vepsäläinen Jouko J, Peräniemi Sirpa. 2015. Advanced material and approach for metal ions removal from aqueous solutions. Scientific Reports 5: 8992. 2015
• Puljula Elina, Turhanen Petri, Vepsäläinen Jouko, Monteil Maelle, Lecouvey Marc, Weisell Janne. 2015. Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters. ACS Medicinal Chemistry Letters 6 4: 397-401. 2015
• Mäenpää Johanna Unelma, Niemi Riikka, Roine Antti, Häkkinen Merja, Kumpulainen Pekka, Keinänen Tuomo, Vepsäläinen Jouko, Lehtimäki Terho, Oksala Niku. 2015. Urinary acetylated polyamines in ovarian cancer. 5543. 2015
• Laakso Mikko P, Jukarainen Niko M, Vepsäläinen Jouko. 2015. Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 86 12: 1286-1290. 2015
• Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R.. 2015. Synthesis of biologically active analogues of spermine and spermidine.Springer. 1667. 2015
• Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR. 2015. Enantioselective synthesis of (R)- and (S)-3-methylspermidines. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 41 5: 548-553. 2015
• Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A. 2015. Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport. ACS Chemical Biology 10 6: 1417-1424. 2015
• Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna. 2015. In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids. CHEMICAL RESEARCH IN TOXICOLOGY 28 4: 702-710. 2015
• Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K. 2014. Eletroninen nenä havaitsee eturauhassyövän virtsasta [Detection of prostate cancer by an eletronic nose: a proof-of-principle study. J Urol, julkaistu verkossa 25.2.2014]. DUODECIM 130: 53. 2014
• Yang Ming, Kuittinen Suvi, Zhang Junhua, Vepsäläinen Jouko, Keinänen Markku, Pappinen Ari. 2014. Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production. BIORESOURCE TECHNOLOGY 2015; 179: 128-135. 2014
• Yang Ming, Kuittinen Suvi, Keinänen Markku, Vepsäläinen Jouko, Romar Henrik, Tynjälä Pekka, Lassi Ulla, Pappinen Ari. 2014. The use of (green field) biomass pretreatment liquor for fermentative butanol production and the catalytic oxidation of biobutanol. Chemical Engineering Research And Design 92 8: 1531-1538. 2014
• Vepsäläinen Jouko. 2014. Uraanin ja muiden raskasmetallien poistaminen vedestä. YMPÄRISTÖ JA TERVEYS 45 2: 72-76. 2014
• Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. 2014. Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS. PHYTOCHEMICAL ANALYSIS 25: 220-228. 2014
• Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2014. Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS. FOOD CHEMISTRY 165: 499-505. 2014
• Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1950-1957. 2014
• Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K. 2014. Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study. JOURNAL OF UROLOGY 192: 230-235. 2014
• Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. 2014. Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. BIOCHEMISTRY (MOSCOW) 2013; 78 13: 1431-1446. 2014
• Keinanen TA, Hyvonen T, Vepsalainen J, Alhonen L, Khomutov AR, Janne J. 2014. Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 40: 155-161. 2014
• Julkunen-Tiitto Riitta, Nenadis Nikolaos, Neugart Susanne, Robson Matthew, Agati Giovanni, Vepsäläinen Jouko, Zipoli Gaetano, Nybakken Line, Winkler Barbro, Jansen Marcel AK. 2014. Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques. Phytochemistry Reviews 2015; 14 2: 273-297. 2014
• Elina Puljula, Aino-Liisa Alanne, Petri Turhanen, Jouko Vepsäläinen, Janne Weisell. 2014. Bisphosphonates: How does the structure affect the ability to bind to hydroxyapatite?, The first PhD student symposium of the faculty of health sciences, "Health research within life span" , Abstracts, poster number 40, page 41. 41. 2014
• Castro-Oropeza R, Pino-Ángeles A, Khomutov MA, Urdiales JL, Moya-García AA, Vepsäläinen J, Persson L, Sarabia F, Khomutov A, Sánchez-Jiménez F. 2014. Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence. AMINO ACIDS 46: 621-631. 2014
• Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R. 2013. Selective regulation of polyamine metabolism with methylated polyamine analogues. AMINO ACIDS 2014:46: 605-620. 2013
• Weisell Janne, Vepsäläinen Jouko, Peräkylä Mikael. 2013. Tautomeric populations of the charged species of 1,12-diamino-3,6,9-triazadodecane (SpmTrien) studied with computer simulations and cluster expansions. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY 26: 360-366. 2013
• Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R. 2013. Charge deficient analogues of the natural polyamines. CURRENT PHARMACEUTICAL DESIGN 2014:20 2: 262-277. 2013
• Turhanen Petri, Peräniemi Sirpa, Vepsäläinen Jouko. 2013. Method for collecting metals. PCT/FI2012/050322. 2013
• Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J. 2013. The selective stepwise chemical hydrolysis of alkylcarbonate groups from novel mixed alkylcarbonate trialkyl ester derivatives of etidronic acid. RSC Advances 3: 2417-2421. 2013
• Sankala, E., Weisell, J. and Vepsäläinen, J. 2013. An in vitro method for determining bisphosphonate-binding to hydroxyapatite by 31P NMR, PhoSciNet final conference, 10th European Workshop On Phosphorous Chemistry (EWPC-10), 18-20.3.2013, Regensburg, Germany. Book of abstracts. 63. 2013
• Sankala, E., Alanne, A.-L., Turhanen, P., Weisell, J. and Vepsäläinen.. 2013. An in vitro method for determining bisphosphonate-binding to hydroxyapatite by 31P NMR, The XXXV Finnish NMR Symposium, 12.-14.6.2013, Hotel Rantasipi Siuntio. Book of Abstracts, Poster p. 10.. P10. 2013
• Meinander Kristian, Weisell Janne, Pakkala Miikka, Tadd Andrew C, Hekim Can, Kallionpää Roope, Widell Kim, Stenman Ulf-Håkan, Koistinen Hannu, Närvänen Ale, Vepsäläinen Jouko, Luthman Kristina, Wallén Erik AA. 2013. Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity. Medicinal Chemistry Communications 4: 549-553. 2013
• Aino-Liisa Alanne, Petri Turhanen, Janne Kankkunen, Sirpa Peräniemi, Jouko Vepsäläinen. 2013. An Insoluble Bisphosphonate as a Metal Collector - an Innovative Solution to the Waste Water Problems of the Mining Industry, PhoSciNet Final Conference @ 10th European Workshop on Phosphorus Chemistry, Book of Abstracts. 28. 2013
• Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 941: 81-89. 2013
• Alanne Aino-Liisa, Lahtinen Manu, Löfman Miika, Turhanen Petri, Kolehmainen Erkki, Vepsäläinen Jouko, Sievänen Elina. 2013. First bisphosphonate hydrogelators: potential composers of biocompatible gels. Journal of Materials Chemistry B (ISSN 2050-750X) 1: 6201-6212. 2013
• Agapkina Julia, Yanvarev Dmitry, Anisenko Andrey, Korolev Sergey, Vepsäläinen Jouko, Kochetkov Sergey, Gottikh Marina. 2013. Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2014:73: 73-82. 2013
• Alanne A, Tuomainen M, Turhanen P, Peräniemi S, Vepsäläinen J, Kärenlmpi S, Tervahauta A. 2013. Effect of bisphosphonates on metal accumulation in the metal hyperaccumulator plan Noccaea caerulescens, Cost Action FA0905 Mineral imroved crop production for healthy food and feed, 4th Annual Conference 9th-13th June 2013, Norwegian University of Life Sciences, Ås. 83. 2013
• Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A. BIOCHEMICAL JOURNAL 453: 467-474. 2013
• Alanne Aino-Liisa, Peräniemi Sirpa, Turhanen Petri, Tuomainen Marjo, Vepsäläinen Jouko, Tervahauta Arja. 2013. A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens. CHEMOSPHERE 2014:95: 566-571. 2013
• Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko. 2013. Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 49: 624-628. 2013
• Alanne Aino-Liisa, Tuikka Matti, Tõnsuaadu Kaia, Ylisirniö Markku, Hämäläinen Lea, Turhanen Petri, Vepsäläinen Jouko, Peräniemi Sirpa. 2013. A novel bisphosphonate-based solid phase method for effective removal of chromium(III) from aqueous solutions and tannery effluents. RSC Advances 3: 14132-14138. 2013
• Roine Antti, Tolvanen Mikko, Sipiläinen Miki, Kumpulainen Pekka, Helenius Merja A, Lehtimäki Terho, Vepsäläinen Jouko, Keinänen Tuomo A, Häkkinen Merja R, Koskimäki Juha, Veskimäe Erik, Tuokko Antti, Visakorpi Tapio, Tammela Teuvo L, Sioris Thanos, Paavonen Timo, Lekkala Jukka, Helle Hannu, Oksala Niku K. 2012. Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose. FUTURE ONCOLOGY 8 9: 1157-1165. 2012
• Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J. 2012. Preparation of mixed trialkyl alkylcarbonate derivates of etidronic acid via an unusual route. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 8: 2019-2024. 2012
• Soininen Tuula H, Jukarainen Niko, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2012. The combined use of constrained total-line-shape 1H NMR and LC-MS/MS for quantitative analysis of bioactive components in yellow onion JOURNAL OF FOOD COMPOSITION AND ANALYSIS 25: 208-214. 2012
• Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V. 2012. Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells BIOCHIMIE 94 9: 1876-1883. 2012
• Sankala Elina, Weisell Janne M, Huhtala Tuulia, Närvänen Ale T.O, Vepsäläinen Jouko J. 2012. Synthesis of novel bisphosphonate polyamine conjugates and their affinity to hydroxyapatite ARKIVOC 2012 4: 233-241. 2012
• Sankala E, Turhanen P, Weisell J, Monteil M, Lecouvey M, Huhtala T, Närvänen A, Vepsäläinen J. 2012. 99mTc-labeled partial esters of etidronic acid and their biodistribution in healthy mice. Teoksessa: (toim.), 9th European Workshop On Phosphorous Chemistry (EWPC-9), 22-23.3.2012, Rennes, France. Book of abstracts. ss. 100. 2012
• Sankala E, Chmielewska E, Vepsäläinen J. 2012. Spectral analysis of ethenylidene bisphosphonates. Teoksessa: (toim.), XXXIV Finnish NMR Symposium, 13.-15.6.2012, Turku. Book of Abstracts. ss. 39. 2012
• Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A. 2012. Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase. DRUG METABOLISM AND DISPOSITION 2013:41: 30-32. 2012
• Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H. 2012. Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. AMINO ACIDS 42: 685-695. 2012
• Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko. 2012. In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin. JOURNAL OF PHARMACEUTICAL SCIENCES 101 8: 2854-2860. 2012
• Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS AMINO ACIDS 42: 451-460. 2012
• Alanne Aino-Liisa, Hyvönen Helena, Lahtinen Manu, Ylisirniö Markku, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko. 2012. Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates. MOLECULES 17 9: 10928-10945. 2012
• Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A. 2012. Metabolism of bilirubin by human cytochrome P450 2A6. TOXICOLOGY AND APPLIED PHARMACOLOGY 261: 50-58. 2012
• Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena. 2012. Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase AMINO ACIDS 42: 485-493. 2012
• Saari, A-L.; Ylisirniö, M.; Lahtinen, M.; Hyvönen, H.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S. and Vepsäläinen, J.. 2011. Alkylaminobisphosphonates: Synthesis, characterization and determination of pKa-values. Teoksessa: (toim.), Advances in Synthetic and Medicinal Chemistry (ASMC11), 21.-25.8.2011, St. Petersburg, Russia, Book of Abstracts. ss. 296. 2011
• Turhanen Petri A, Weisell Janne, Lehtolainen-Dalkilic Pauliina, Määttä Ann-Marie, Vepsäläinen Jouko, Närvänen Ale. 2011. A novel strategy for the synthesis of enzymatically stable biotin-DOTA conjugates for in vivo use. Medicinal Chemistry Communications 2 2: 886-888. 2011
• Soininen, T., Jukarainen, N., Julkunen-Tiitto, R., Karjalainen, R., Vepsäläinen, J.. 2011. Quantitative analysis of onion species metabolites by NMR spectroscopy. Teoksessa: (toim.), 5th International conference on polyphenols and health. ss. 173. 2011
• Sankala E, Vepsäläinen J, Närvänen A, Weisell J. 2011. Novel polyamine bisphosphonates: synthesis, radiolabelling and affinity to hydroxyapatite. Teoksessa: (toim.), XII Spring Meeting of the Division of Synthetic Chemistry and XXXIII Finnish NMR Symposium, 7.-10.6.2011, Jyväskylä. Research Report No. 145, Book of Abstract. ss. 40. 2011
• Sankala E, Vepsäläinen J, Närvänen A, Weisell J. 2011. Novel polyamine bisphosphonates: synthesis, radiolabelling and affinity to hydroxyapatite. Teoksessa: (toim.), Advances in Synthetic and Medicinal Chemistry (ASMC11), 21.-25.8.2011, St. Petersburg, Russia. Book of Abstract. ss. 290. 2011
• Saari, A-L.; Ylisirniö, M.; Lahtinen, M.; Hyvönen, H.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S. and Vepsäläinen, J.. 2011. Alkylaminobisphosphonates: Synthesis, characterization and determination of pKa-values. Teoksessa: (toim.), XII Spring meeting of the Division of Synthetic chemistry and XXXIII Finnish NMR Symposium, 7.-10.6.2011, Jyväskylä. Research Report No. 145, Book of Abstracts. ss. 79. 2011
• Saari Aino-Liisa, Ylisirniö, Markku, Lahtinen Manu, Hyvönen Helena, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko. 2011. Synthesis, Characterization and determination of pKa-values of alkylaminobisphosphonates. Teoksessa: (toim.), 8th European Workshop on Phosphorus Chemistry, 28.-29.3.2011, Münster, Germany, Abstracts. ss. 96. 2011
• Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen. 2011. Complex N-Acetylation of Triethylentetramine. DRUG METABOLISM AND DISPOSITION 39 12: 2242-2249. 2011
• Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA. 2011. Novel metabolically stable functionally active mimetic of spermidine RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 37 2: 253-258. 2011
• Khomutov Alex R, Weisell Janne, Khomutov Maxim A, Grigorenko Nikolay A, Simonian Alina R, Häkkinen Merja R, Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Kochetkov Sergey N, Vepsäinen Jouko. 2011. Methylated polyamines as research tools: Pegg, A.E. ja Casero, R.A. Jr., Polyamines. Methods and Protocols. Methods in Molecular Biology 720. 449-461. 2011
• Jukarainen Niko, Soininen Tuula, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko. 2011. Quantitative Analysis of Onion Metabolic Composition Based on NMR Spectroscopy. Teoksessa: (toim.), XII Sping Meeting of the Division of Synthetic Chemistry and XXXIII Finnish NMR Symposium, 7.-10.6.2011, Jyväskylä.. ss. 65. 2011
• Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov. 2011. The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism JOURNAL OF MEDICINAL CHEMISTRY 54 13: 4611-4618. 2011
• Maxim A. Khomutov, Swati Mandal, Janne Weisell, Neiha Saxena, Alina R. Simonian, Jouko Vepsalainen, Rentala Madhubala, Sergey N. Kochetkov. 2010. Novel convenient synthesis of biologically active esters of hydroxylamine. AMINO ACIDS 38: 509-517. 2010
• Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P. 2010. Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity. AMINO ACIDS 38 2: 501-507. 2010
• Pakkala M, Weisell J, Hekim C, Vepsäläinen J, Wallen E, Stenman U-H, Koistinen H, Närvänen A.. 2010. Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3 stimulating peptide B-2.. AMINO ACIDS 39 1: 233-236. 2010
• Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ. 2010. DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage. BIOMACROMOLECULES 11: 97-105. 2010
• Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues. JOURNAL OF MEDICINAL CHEMISTRY 53 15: 5738-5748. 2010
• Kunnas-Hiltunen S, Laurila E, Haukka M, Vepsäläinen JJ & Ahlgrén M. 2010. Organic-Inorganic Hybrid Materials: Synthesis, X-ray Diffraction Study and Characterisations of Manganese, Coboalt and Copper Complexes of Modified Bis(phosphonates). Zeitschrift für anorganische und allgemeine Chemie 636: 710-720. 2010
• Komissarov VV, Kritzyn AM & Vepsäläinen J. 2010. A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 6 63: 1-5. 2010
• Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases. AMINO ACIDS 38: 369-381. 2010
• Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L. 2010. Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis PANCREATOLOGY 10: 208-221. 2010
• Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L. 2010. alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage. AMINO ACIDS 38: 575-581. 2010
• Kunnas-Hiltunen S, Haukka M, Vepsäläinen JJ & Ahlgrén M. 2010. Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products. DALTON TRANSACTIONS 39: 5310-5318. 2010
• Jokiniemi J, Vepsäläinen J, Ahlgrén M. 2009. catena-Poly[[diaquacadmium(II)]-mu-(methyl morpholino dicholromethylene-disphosphonato)-kappa3O,O':O''-[tetraaqua-cadmium(II)-mu-(methyl morpholino dichloromethylenediphosphonato)-kappa3O:O',O'']. ACTA CRYSTALLOGRAPHICA. SECTION E. STRUCTURE REPORTS ONLINE [ELECTRONIC RESOURCE] E65: M600-M601. 2009
• Kunnas-Hiltunen S, Matilainen M, Vepsäläinen JJ, Ahlgrén M. 2009. X-ray diffraction study of bisphosphonate metal complexes: Mg, Sr and Ba complexes of (dichloromethylene)bisphosphonic acid P,P'-dibenzoyl anhydride POLYHEDRON 28: 200-204. 2009
• Kunnas-Hiltunen S, Haukka M, Vepsäläinen J, Ahlgrén M. 2009. Syntheses, X-ray diffraction study and characterisations of Ni an Zn complexes of clodronic acid and its dibenzoyl derivate. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY: 5335-5345. 2009
• Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism. MOLEKULIARNAIA BIOLOGIIA [MOSKVA] 43 2: 274-285. 2009
• Jokiniemi J, Vepsäläinen J, Nätkinniemi H, Peräniemi S, Ahlgrén M. 2009. Synthesis of phenyl substituted bisphosphonates and crystal structures and characterization of Cd complexes of (dichloromethylene)bisphosphonic acid phenyl and alkyl ester derivatives. CRYSTENGCOMM 11: 2431-2440. 2009
• Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2009. Poly[(acetone)tetraaqua[my6-ethyl(dichloromethylene)diphosphonato]-[my5-ethyl (dichloromethylene)-diphosphonato]tribarium(II)]. ACTA CRYSTALLOGRAPHICA SECTION C [PRINTED AND ONLINE: HTTP://WWW.IUCR.ORG/] C65: m165-m167. 2009
• Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2009. Poly[[my-aqua-aqua[myy4-ethyl(dichloromethylene)diphosphonato]sesquicalcium(II)] acetone hemisolvate 4.5-hydrate] ACTA CRYSTALLOGRAPHICA. SECTION E. STRUCTURE REPORTS ONLINE [ELECTRONIC RESOURCE] E65: m436-m437. 2009
• Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Synthesis of novel deuterium labelled derivates of N-alkylated polyamines. TETRAHEDRON 65 2: 547-562. 2009
• Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA. 2009. Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues BIOCHEMICAL JOURNAL 422: 321-328. 2009
• Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P. 2009. Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 50: 469-474. 2009
• Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. 2009. The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption. JOURNAL OF MEDICINAL CHEMISTRY 52: 4142-4148. 2009
• Turhanen PA, Vepsäläinen JJ. 2008. Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 4 7. 2008
• Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J. 2008. Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 34: 110-117. 2008
• Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R. 2008. Novel agmatine analogue, gamma-quanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 375: 168-172. 2008
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 48: 414-421. 2008
• Koivula T, Marjamäki P, Haaparanta M, Fagerholm V, Grönroos T, Lipponen T, Perhola O, Vepsäläinen J, Solin O. 2008. Ex vivo evaluation of N(3-[18F]fluoroproponyl9-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane in rats. NUCLEAR MEDICINE AND BIOLOGY 35: 177-183. 2008
• Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2008. A structural study of alkaline earth metal complexes of (dicholoromethylene)bisphosphonic acid P-morpholinium- and P-pyrrolidinium-P'-methyl esters CRYSTENGCOMM 10: 1011-1017. 2008
• Huttunen KM, Leppänen J, Kemppainen E, Palonen P, Rautio J, Järvinen T, Vepsäläinen J. 2008. Towards metformin prodrugs SYNTHESIS 22: 3619-3624. 2008
• Jukarainen NM, Korhonen S-P, Laakso MP, Korolainen MA, Niemitz M, Soininen PP, Tuppurainen K, Vepsäläinen J, Pirttilä T, Laatikainen R, Pirttilä T. 2008. Quantification of 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis. METABOLOMICS 4: 150-160. 2008
• Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. 2007. Alpha-methylated polyamines as potential drugs and experimental tools in enzymology. MINI REVIEWS IN MEDICINAL CHEMISTRY 7 8: 813-820. 2007
• Turhanen PA, Demadis KD, Peräniemi S, Vepsäläinen JJ. 2007. A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterfied derivatives JOURNAL OF ORGANIC CHEMISTRY 72 4: 1468-1471. 2007
• Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J. 2007. Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS 26: 1245-1248. 2007
• Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman U-H, Vepsäläinen J, Närväinen A. 2007. Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. JOURNAL OF PEPTIDE SCIENCE 13: 348-353. 2007
• Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L. 2007. Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis AMINO ACIDS 33 2: 323-330. 2007
• Jokiniemi J, Vuokila-Laine E, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2007. Structural study of metal complexes of bisphosphonate amide ester: copper, magnesium, zinc and cadmium complexes of (dichloromethylene)bisphosphonic acid P-piperidinium-P¿-methyl ester. CRYSTENGCOMM 9: 158-164. 2007
• Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JAM, Forsberg MM, Männistö PT, Wallén EAA. 2007. 2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY 15: 2024-2031. 2007
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 45: 625-634. 2007
• Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. 2007. Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 282 48: 34700-34706. 2007
• Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J. 2007. Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality PHARMACEUTICAL RESEARCH 24 4: 679-687. 2007
• Grigorenko NA, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J. 2007. Synthesis of novel optical isomers of [alpha]-methylpolyamines. TETRAHEDRON 63: 2257-2262. 2007
• Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J. 2006. Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure. JOURNAL OF MEDICINAL CHEMISTRY 49: 1207-1211. 2006
• Turhanen P, Vepsalainen JJ. 2006. Synthesis of novel (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY [ONLINE: HTTP://BJOC.BEILSTEIN-JOURNALS.ORG/] 2:2. 2006
• Simonyan AR, Vepsalainen J, Khomutov AR. 2006. Aminooxy analogues of spermine and their monoacetyl derivatives. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 32 6: 578-585. 2006
• Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J. 2006. Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists. CHEMICAL BIOLOGY AND DRUG DESIGN 68 6: 334-340. 2006
• Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates BRITISH JOURNAL OF PHARMACOLOGY 147: 437-445. 2006
• Lewandowicz AM, Vepsäläinen J, Laitinen JT. 2006. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms BRITISH JOURNAL OF PHARMACOLOGY 147: 422-429. 2006
• Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J. 2006. Convenient microwave-assisted synthesis of 1-chloroethyl phosphates. CHEMINFORM 37 26. 2006
• Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. 2006. Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists. JOURNAL OF MEDICINAL CHEMISTRY 49: 2022-2027. 2006
• Keinänen T, Järvinen A, Vepsäläinen J, Uimari A, Alhonen L, Jänne J. 2006. Controlling the regio- and stereospecifity of enzyme catalysis with guide molecules. WO 2006/134224. Suomi. 2006
• Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J. 2006. Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase. JOURNAL OF BIOLOGICAL CHEMISTRY 281 8: 4589-4595. 2006
• Jokiniemi J, Ahlgrén M, Vepsäläinen JJ. 2006. Novel one-pot synthesis of amide derivatives of methylenebisphosphonate utilizing the mesyl moiety as leaving group. LETTERS IN ORGANIC CHEMISTRY 3 12: 898-900. 2006
• Jarho EM, Venäläinen J, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JAM, Forsberg MM, Järvinen T, Männistö PT, Wallén EAA. 2006. An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 16: 5590-5593. 2006
• Holappa J, Nevalainen T, Safin R, Vepsäläinen J, Järvinen T. 2006. A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts. TETRAHEDRON LETTERS 47: 323-325. 2006
• Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. 2006. Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. AMERICAN JOURNAL OF PATHOLOGY 168: 115-122. 2006
• Huttunen KM, Kumpulainen H, Leppänen J, Rautio J, Järvinen T, Vepsäläinen J. 2006. Efficient strategy to prepare water-soluble prodrugs of ketones. SYNLETT 5: 701-704. 2006
• Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE. 2006. Alfa-methyl polyamines: efficient synthesis and tolerance studies in vivo and vitro. First evidence for dormant stereospecificity of polyamine oxidase. JOURNAL OF MEDICINAL CHEMISTRY 49: 399-406. 2006
• Simonyan AR, Grigorenko NA, Vepsalainen J, Khomutov AR. 2005. New charge-deficient agmatine analogues. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 6: 583-587. 2005
• Kritzyn AM, Vepsalainen J, Komissarov VV. 2005. Polymethylene derivatives of nucleic bases with omega-functional groups: IV.1[7-(2-oxocyclohexyl)-7-oxoheptyl]purines. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 3: 256-262. 2005
• Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J. 2005. An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates. JOURNAL OF ORGANIC CHEMISTRY 70: 9056-9058. 2005
• Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. 2005. Isolation and characterization of yuremamine, a new phytoindole. PLANTA MEDICA 71: 1053-1057. 2005
• Sivets GG, Vepsäläinen J, Mikhailopulo IA. 2005. Synthesis of 9-[2-O-(2-methoxyethyl)-beta-D-ribofuranosyl]purines using 1-methanesulfonyloxy-2-methoxyethane. LETTERS IN ORGANIC CHEMISTRY 2: 343-348. 2005
• Soininen P, Haarala J, Vepsäläinen J, Niemitz M, Laatikainen R. 2005. Strategies for organic impurity quantification by 1H NMR spectroscopy: constrained total-line-shape fitting. ANALYTICA CHIMICA ACTA (AMSTERDAM) 542 2: 178-185. 2005
• Turhanen PA, Vepsäläinen JJ. 2005. Synthesis of novel fatty acid derivatives of etidronic acid. SYNTHESIS 18: 3063-3066. 2005
• Turhanen PA, Vepsäläinen JJ. 2005. The first synthesis of novel (1-alkoxycarbonyloxyethylidene)-1,1-bisphosphonic acid derivatives taking advantage of the rearrangement characteristic of the tetramethyl ester of etidronate SYNTHESIS 13: 2119-2121. 2005
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. X-ray diffraction study of bisphosphonate metal complexes: Mg and Ca complexes of (dichloromethylene)bisphosphonic acid P,P'-diisopropyl ester. POLYHEDRON 24: 305-309. 2005
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Catena-Poly[diaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O,O':O''-tetraaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O:O',O'']. ACTA CRYSTALLOGRAPHICA SECTION C [PRINTED AND ONLINE: HTTP://WWW.IUCR.ORG/] E61: m635-m637. 2005
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Catena-poly[diaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o,ó:o" -tetraaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o:ó,o"] ACTA CRYSTALLOGRAPHICA. SECTION E. STRUCTURE REPORTS ONLINE [ELECTRONIC RESOURCE] E61: m635-m637. 2005
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Catena-poly[diaquacadmium(II)-my-(diethyl dichloromethylenebisphosphonato)-kappa3 O,O':O'' -tetraaquacadmium(II)-my -(diethyl dichloromethylenebisphosphonato-)kappa3 O:O',O'']. ACTA CRYSTALLOGRAPHICA SECTION C [PRINTED AND ONLINE: HTTP://WWW.IUCR.ORG/] E61: m638-m640. 2005
• Kontturi M, Laurila E, Mattsson R, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Structures of bisphosphonate metal complexes: zinc and cadmium complexes of clodronate and its partial ester derivatives. INORGANIC CHEMISTRY 44: 2400-2406. 2005
• Koivula T, Perhola O, Kämäräinen E-L, Lipponen T, Vepsäläinen J, Solin O. 2005. Simplified synthesis of N-(3-[18F]-fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)-nortropane([18F]beta-CFT-FP using [18F]fluoropropyl tosylate as the labelling reagent. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 48: 463-471. 2005
• Khomutov AR, Simonyan AR, Vepsalainen J, Keinanen TA, Alhonen L, Janne J. 2005. New oxaanalogues of spermine. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 2: 189-195. 2005
• Khomutov AR, Grigorenko NA, Skuridin SG, Demin AV, Vepsalainen J, Casero RA, Woster PM. 2005. A charge-deficient analogue of spermine with chelating properties. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 3: 271-278. 2005
• Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J. 2005. Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines. JOURNAL OF BIOLOGICAL CHEMISTRY 280 8: 6595-6601. 2005
• Grigorenko NA, Vepsalainen JJ, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR. 2005. Synthesis of (R)- and (S)-isomers of 1-methylspermidine MENDELEEV COMMUNICATIONS 15 4: 142-143. 2005
• Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR. 2005. New syntheses of alfa-methyl- and alfa,alfa'-dimethylspermine. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 31 2: 183-188. 2005
• Airaksinen AJ, Huotari M, Shvetsov A, Vainiotalo P, Männisto PT, Tuomisto L, Bergström K, Vepsäläinen J. 2005. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 40 3: 299-304. 2005
• Turhanen PA, Vepsäläinen JJ. 2004. Strategies for the preparation of (1-acetyloxyethylidene)-1,1-bisphosphonic acid derivatives. SYNTHESIS 7: 0992-0994. 2004
• Mäntylä A, Rautio J, Nevalainen T, Keski-Rahkonen P, Vepsäläinen J, Järvinen T. 2004. Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 23: 151-158. 2004
• Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J. 2004. Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration. US2004/0180968 A1. Yhdysvallat (USA). 2004
• Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J. 2004. Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration (in Japanese). JP2004/189714 A. Japani. 2004
• Pakkala M, Jylhäsalmi A, Wu P, Leinonen J, Stenman U-H, Santa H, Vepsäläinen J, Peräkylä M, Närvänen A. 2004. Conformational and biochemical analysis of the cyclic peptides which modulate serine protease activity. JOURNAL OF PEPTIDE SCIENCE 10: 439-447. 2004
• Mäntylä A, Rautio J, Nevalainen T, Vepsälainen J, Juvonen R, Kendrick H, Garnier T, Croft SL, Järvinen T. 2004. Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives. BIOORGANIC AND MEDICINAL CHEMISTRY 12: 3497-3502. 2004
• Turhanen PA, Soininen P, Vepsäläinen JJ. 2004. One-pot synthesis of 1-[(1-phenyl-1-dialkoxyphosphoryl)-methyl]-2-pyrrolidinone. LETTERS IN ORGANIC CHEMISTRY 1: 343-345. 2004
• Mäntylä A, Garnier T, Rautio J, Nevalainen T, Vepsäläinen J, Koskinen A, Croft SL, Järvinen T. 2004. Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone. JOURNAL OF MEDICINAL CHEMISTRY 47: 188-195. 2004
• Joutsensaari J, Toivonen T, Vaattovaara P, Vesterinen M, Vepsäläinen J, Laaksonen A. 2004. Time-resolved growth behavior of acid aerosols in ethanol vapor with a tandem-DMA technique. JOURNAL OF AEROSOL SCIENCE 35: 851-867. 2004
• Gul HI, Calis U, Vepsäläinen J. 2004. Synthesis of some mono-mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity. ARZNEIMITTEL-FORSCHUNG 54 7: 359-364. 2004
• Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. 2004. Effects of triaryl phosphates on mouse and human nuclear receptors BIOCHEMICAL PHARMACOLOGY 67: 97-106. 2004
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. Poly[[tetraaqua(my7-hydrogen dichloromethylenebisphosphonato)(my5-hydrogen dichloromethylenebisphosphonato)tribarium(II)] monohydrate). ACTA CRYSTALLOGRAPHICA SECTION C [PRINTED AND ONLINE: HTTP://WWW.IUCR.ORG/] C60: m592-m594. 2004
• Kalinichenko EN, Podkopaeva TL, Budko EV, Seela F, Dong B, Silverman R, Vepsäläinen J, Torrence PF, Mikhailopulo IA. 2004. 3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L. BIOORGANIC AND MEDICINAL CHEMISTRY 12: 3637-3647. 2004
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. A structural study of bisphosphonate metal complexes - three new polymeric structures of the calcium complex of clodronic acid EUROPEAN JOURNAL OF INORGANIC CHEMISTRY: 2627-2631. 2004
• Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. Pentaaqua (dichloromethylenebisphosphonato)strontium(II). ACTA CRYSTALLOGRAPHICA SECTION C [PRINTED AND ONLINE: HTTP://WWW.IUCR.ORG/] E60: m1060-m1062. 2004
• Airaksinen AJ, Lipsonen J, Ahlgren M, Vainiotalo P, Bergström KA, Laatikainen R, Vepsäläinen J. 2003. Reduction of 6/7-substituted 3-phenyltrop-3-en-2-ones: stereoselectivity and conformational analysis of the products. TETRAHEDRON 59: 377-383. 2003
• Gul HI, Gul M, Vepsälainen J, Erciyas E, Hänninen O. 2003. Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells. BIOLOGICAL AND PHARMACEUTICAL BULLETIN 26 5: 631-637. 2003
• Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. 2003. Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether JOURNAL OF MEDICINAL CHEMISTRY 46: 5083-5086. 2003
• Järvinen T, Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J. 2003. Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön. FI 110921 B. Suomi. 2003
• Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*. JOURNAL OF BIOLOGICAL CHEMISTRY 278 46: 45915-45923. 2003
• Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: 23-29. 2003
• Turhanen PA, Niemi R, Peräkylä M, Järvinen T, Vepsäläinen JJ. 2003. First synthesis of etidronate partial amides starting from PCI3 ORGANIC AND BIOMOLECULAR CHEMISTRY 1: 3223-3226. 2003
• Wallén EAA, Christiaans JAM, Gynther J, Vepsäläinen J. 2003. Addition of tert-butylcuprate to (2S)-N-acyl-delta5-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2S,5S)-5-tert-butylproline TETRAHEDRON LETTERS 44: 2081-2082. 2003
• Yu M, Airaksinen AJ, Gee AD, Lötjönen S, Kuikka JT, Vepsäläinen JJ, Hiltunen J, Bergström KA. 2002. Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2a-(imino-methyl)-3b-(3',4'-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 45: 1011-1017. 2002
• Vepsäläinen JJ. 2002. Bisphosphonate prodrugs CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 9: 1075-1085. 2002
• Räsänen T-L, Alhonen L, Sinervirta R, Keinänen T, Herzig K-H, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J. 2002. A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 277 42: 39867-39872. 2002
• Roivainen J, Vepsäläinen J, Azhayev A, Mikhailopulo IA. 2002. Synthesis of anhydro psicofuranosyl nucleosides. TETRAHEDRON LETTERS 43: 6553-6555. 2002
• Mäntylä A, Vepsäläinen J, Järvinen T, Nevalainen T. 2002. A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates. TETRAHEDRON LETTERS 43: 3793-3794. 2002
• Gul HI, Calis U, Vepsalainen J. 2002. Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols. ARZNEIMITTEL-FORSCHUNG 52 12: 863-869. 2002
• Airaksinen AJ, Ahlgren M, Vepsäläinen J. 2002. One-pot synthesis of 3,4-disubstituted 1H-pyrroles from 2-tropanones. JOURNAL OF ORGANIC CHEMISTRY 67: 5019-5021. 2002
• Kontturi M, Vuokila-Laine E, Peräniemi S, Pakkanen TT, Vepsäläinen JJ, Ahlgrén M. 2002. A structural study of bisphosphonate metal complexes. Alkaline earth metal complexes of (dichloromethylene)bisphosphonic acid P,P' -diethyl ester JOURNAL OF THE CHEMICAL SOCIETY. DALTON TRANSACTIONS: 1969-1973. 2002
• Gul HI, Ojanen T, Vepsalainen J, Gul M, Erciyas E, Hanninen O. 2001. Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone ARZNEIMITTEL-FORSCHUNG I 51: 72-75. 2001
• Gul M, Gul HI, Vepsalainen J, Erciyas E, Hanninen O. 2001. Effect of acetophenone derived Mannich bases on cellular glutathione level in Jurkat cells. ARZNEIMITTEL-FORSCHUNG 51 II: 679-682. 2001
• Khomutov AR, Shvetsov AS, Vepsäläinen JJ, Kritzyn AM. 2001. Novel acid-free cleavage of N-(2-hydroxyarylidene) protected amines. TETRAHEDRON LETTERS 42: 2887-2889. 2001
• Raiman J, Niemi R, Vepsäläinen J, Yritys K, Järvinen T, Mönkkönen J. 2001. Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS 213: 135-142. 2001
• Tupala E, Kuikka JT, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Hiltunen J, Vepsäläinen J, Tiihonen J. 2001. Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography. NEUROIMAGE 14: 87-94. 2001
• Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen J. 2001. Bisphosphonate prodrugs: selective synthesis of (1-hydroxyethylidene)-1,1-bisphosphonate partial esters SYNTHESIS 4: 633-637. 2001
• Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen JJ. 2001. Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and X-ray crystallography. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS 170: 115-133. 2001
• Pohjola EK, Vepsäläinen J, Nupponen H, Kähkönen JP, Lauren L, Hannuniemi R, Järvinen TL, Ahlmark MJ. 2000. Uudet metyleenibisfosfonihappojohdannaiset. 104901. Suomi. 2000
• Tennilä T, Azhayeva E, Vepsäläinen J, Laatikainen R, Azhayev A, Mikhailopulo IA. 2000. Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS 19 10-12: 1861-1884. 2000
• Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery JOURNAL OF MEDICINAL CHEMISTRY 43 8: 1489-1494. 2000
• Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 11: 157-163. 2000
• Pulkkinen JT, Laatikainen R, Ahlgrén MJ, Peräkylä M, Vepsäläinen JJ. 2000. Conformational flexibility and role of aromatic-aromatic interactions in the crystal packing of the coordination compounds of some novel quadridentate Schiff bases. JOURNAL OF THE CHEMICAL SOCIETY. PERKIN 2 2: 777-784. 2000
• Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T. 2000. Synthesis of a water-soluble prodrug of entacapone. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 10: 1967-1969. 2000
• Niemi R, Turhanen P, Vepsäläinen J, Taipale H, Järvinen T. 2000. Bisphosphonate prodrugs: synthesis and vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 11: 173-180. 2000
• Kovalainen JT, Christiaans JAM, Ropponen R, Poso A, Peräkylä M, Vepsäläinen J, Laatikainen R, Gynther J. 2000. A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 122 29: 6989-6996. 2000
• Gul HI, Vepsalainen J, Gul M, Erciyas E, Hanninen O. 2000. Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells PHARMACEUTICA ACTA HELVETIAE 74: 393-398. 2000
• Ahlmark MJ, Vepsäläinen JJ. 2000. Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters. TETRAHEDRON 56: 5213-5219. 2000
• Kämäräinen E-L, Kyllönen T, Airaksinen A, Lundkvist C, Yu M, Någren K, Sandell J, Langer O, Vepsäläinen J, Hiltunen J, Bergström K, Lötjönen S, Jaakkola T, Halldin C. 2000. Preparation of (18F)beta-CFT-FP and (11C)beta-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET). JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 43: 1235-1244. 2000
• Pohjola E, Vepsäläinen J, Nupponen H, Kähkönen J, Laurén L, Hannuniemi R, Järvinen T, Ahlmark M. 1999. Novel methylenebisphosphonic acid derivatives. WO 99/20634. Ei tiedossa / Ei annettu. 1999
• Vepsäläinen JJ. 1999. Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates. TETRAHEDRON LETTERS 40: 8491-8493. 1999
• Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T. 1999. Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid as novel naproxen prodrugs for dermal drug delivery. PHARMACEUTICAL RESEARCH 16 8: 1172-1178. 1999
• Pulkkinen JT, Laatikainen R, Vepsäläinen JJ, Ahlgrén MJ. 1999. Characterization of a conformationally flexible system: NMR spectroscopic study of 1,5-diphenylpentane-2,4-dione. MAGNETIC RESONANCE IN CHEMISTRY 37: 119-126. 1999
• Kovalainen JT, Christiaans JAM, Poso A, Vepsäläinen J, Laatikainen R, Gynther J. 1999. 1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists. TETRAHEDRON LETTERS 40: 2425-2428. 1999
• Niemi R, Vepsäläinen J, Taipale H, Järvinen T. 1999. Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid. JOURNAL OF MEDICINAL CHEMISTRY 42 24: 5053-5058. 1999
• Bergström K, Airaksinen A, Lötjönen S, Kuikka J, Vepsäläinen J. 1999. Radiolääkekehitys avaa uusia ikkunoita aivoihin. KEMIA-KEMI 26 5: 391-394. 1999
• Airaksinen AJ, Tuppurainen KA, Lötjönen SE, Niemitz M, Yu M, Vepsäläinen JJ, Laatikainen R, Hiltunen J, Bergström KA. 1999. Nuclear magnetic resonance and molecular orbital study of some cocaine analogues TETRAHEDRON 55: 10537-10546. 1999
• Ahlmark M, Vepsäläinen J, Taipale H, Niemi R, Järvinen T. 1999. Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate. JOURNAL OF MEDICINAL CHEMISTRY 42 8: 1473-1476. 1999
• 3rd Spring Meeting on the Division of Synthetic Chemistry Kuopio June 1-2, 1999. Abstracts. 21st Finnish NMR Symposium. Kuopio June 2-4, 1999. Abstracts. Vepsäläinen J. 1999 1999
• Niemi R, Pennanen H, Vepsäläinen J, Taipale H, Järvinen T. 1998. Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel partial amides of clodronic acid. INTERNATIONAL JOURNAL OF PHARMACEUTICS 174: 111-115. 1998
• Rautio J, Taipale H, Gynther J, Vepsäläinen J, Nevalainen T, Järvinen T. 1998. In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen. JOURNAL OF PHARMACEUTICAL SCIENCES 87 12: 1622-1628. 1998
• Niemi R, Taipale H, Ahlmark M, Vepsäläinen J, Järvinen T. 1997. Simultaneous determination of clodronate and its partial ester derivatives by ion-pair reversed-phase high-performance liquid chromatography coupled with evaporative light-scattering detection. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 701: 97-102. 1997
• Vepsäläinen J, Vainiotalo P, Nupponen H, Pohjola E. 1997. Preparation and identification of tetraamide esters of methylene- and (dichloromethylene)bisphosphonates ACTA CHEMICA SCANDINAVICA 51: 932-937. 1997
• Ahlmark MJ, Vepsäläinen JJ. 1997. Strategies for the selective synthesis of monosubstituted (dichloromethylene)bisphosphonate esters. TETRAHEDRON 53 47: 16153-16160. 1997
• Kolehmainen E, Laihia K, Laatikainen R, Vepsäläinen J, Niemitz M, Suontamo R. 1997. Complete spectral analysis of the 1H NMR 16-spin system of beta-pinene MAGNETIC RESONANCE IN CHEMISTRY 35: 463-467. 1997
• Hakalehto E, Santa H, Vepsäläinen J, Laatikainen R, Finne J. 1997. Identification of a common structural motif in the disordered N-terminal region of bacterial flagellins Evidence for a new class of fibril-forming peptides. FEBS JOURNAL 250: 19-29. 1997
• Aulaskari P, Ahlgrén M, Rouvinen J, Vainiotalo P, Pohjala E, Vepsäläinen J. 1996. Preparation and structure determination of 1-benzyl-, 1-methyl- and 1H-5-[(nitro-2-phenyl)ethenyl]imidazoles. JOURNAL OF HETEROCYCLIC CHEMISTRY 33: 1345-1354. 1996
• Khomutov AR, Shvetsov AS, Vepsalainen J, Kramer DL, Hyvonen T, Keinanen T, Eloranta TO, Porter CW, Khomutov RM. 1996. New aminooxy analogs of biogenic polyamines (in Russian) BIOORGANICHESKAIA KHIMIIA 22 7: 557-559. 1996
• Khomutov AR, Vepsäläinen JJ, Shvetsov AS, Hyvönen T, Keinänen TA, Pustobaev VN, Eloranta TO, Khomutov RM. 1996. Synthesis of hydroxylamine analogues of polyamines TETRAHEDRON 52 43: 13751-13766. 1996
• Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T, Vepsäläinen J. 1996. General strategies for total-lineshape-type spectral analysis of NMR spectra using integral-transform iterator JOURNAL OF MAGNETIC RESONANCE (A) 120: 1-10. 1996
• Laihia K, Kolehmainen E, Mänttäri P, Ryynänen R, Messala-Rannanpiha M, Vepsäläinen J, Sundelin J-P. 1996. Performic acid oxidation of exo-2-syn-7-bicyclo[2.2.1]hept-5-enediol. 1H and 13C NMR spectroscopic structure elucidation of the reaction products. SPECTROCHIMICA ACTA. PART A. MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 51: 495-504. 1996
• Pulkkinen JT, Vepsäläinen JJ. 1996. 3-unsubstituted 1,5-Diaryl-2,4-pentanediones and -4-methoxy-2- pentanones: Synthesis via corresponding 3-hydroxy ketones generated from 2-isoxazolines. JOURNAL OF ORGANIC CHEMISTRY 61: 8604-8609. 1996
• Vepsäläinen J, Nupponen H, Pohjola E. 1996. Bisphosphonic compounds VIII. A facile and selective one-pot synthesis of P,P-dialkyl (dichloromethylene)bisphosphonate partial esters. TETRAHEDRON LETTERS 37 20: 3533-3536. 1996
• Angelis de S, Batsanov A, Norman TJ, Parker D, Senanayake K, Vepsalainen J. 1995. Conformationally biased tri- and di-basic 1,3,5-triazacyclohexyl ligands. CHEMICAL COMMUNICATIONS: 2361-2363. 1995
• Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A. 1995. Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions. JOURNAL OF PHARMACEUTICAL SCIENCES 84 5: 656-660. 1995
• Kovalainen JT, Morimoto H, Williams PG, Vepsäläinen J, Reijonen A, Gynther J. 1995. Synthesis of a tritium labelled antihistaminic drug [3H]-N,N-diethyl-2-[4-(phenylmethylphenoxy]-ethaneamine * HCl. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 36 12: 1147-1156. 1995
• Vepsäläinen JJ, Kivikoski J, Ahlgrén M, Nupponen HE, Pohjola EK. 1995. An improved synthetic method and the first crystal structures for (dihalomethylene)bisphosphonate partial esters. TETRAHEDRON 51 24: 6805-6818. 1995
• Pulkkinen, Juha; Vepsäläinen, Jouko; Laatikainen, Reino. 1994. A general route to 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones. TETRAHEDRON LETTERS 35 52: 9749-9750. 1994