Jouko Vepsäläinen
Professor
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 355 3256
Research groups
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Biorefining 01.01.2010 -
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Analytical unit of the school of Pharmacy 27.02.2020 -
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Medicinal chemistry and organic synthesis facilities 01.01.2010 -
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Microplastics and health
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Microplastic research 01.09.2016 -
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Applied chemistry 01.01.2012 -
Projects
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Ensuring food safety and developing analytical methods 01.01.2023 - 31.12.2025
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Environmental efficiency for mineral processing through the innovation network – INNOMIN 01.01.2025 - 31.08.2026
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Analysis and removal methods of microplastics for industrial quality control Finished 18.02.2022 - 31.10.2023
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Direct microplastic exposure via foodstuff and food packaging - plastic leachables and their health effects (diMPex) Finished 01.09.2020 - 31.08.2024
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WInEco - Water Innovation Ecosystem Finished 01.01.2023 - 31.05.2025
Publications
268/268 items-
A study protocol for chemical analysis and toxicity testing of virgin and recycled microplastics and associated chemicals
Järvelä, Essi; Peräniemi, Sirpa; Vepsäläinen, Jouko; Hrovat, Blaž; Raninen, Kaisa; Tomppo, Laura; Koistinen, Arto; Rysä, Jaana, 2025, Science of the total environment, 975, 179287. A1 Journal article (refereed), original research -
Advancements and feasibility of synergistic approaches in phosphorus recovery from wastewater: A critical review
Kaur, Parminder; Szlachta, Małgorzata; Xu, Junhua; Vepsäläinen, Jouko; Lappalainen, Reijo; Hussin, Farihahusnah; Aroua, Mohamed Kheireddine, 2025, Journal of environmental management, 386, 125786. A2 Review article, Literature review, Systematic review -
Bisphosphonate functionalized biogenic nanostructured silicon carbide for uranium and scandium recovery
Iftekhar, Sidra; Haluska, Ondřej; Rahmani, Arezoo; Thapa, Rinez; Riikonen, Joakim; Lappalainen, Reijo; Vepsäläinen, Jouko; Lehto, Vesa-Pekka, 2025, Chemosphere, 379, 144404. A1 Journal article (refereed), original research -
Urinary levels of oestradiol and pregnanediol glucuronides reflect the ovarian function in the domestic dog (Canis familiaris)
Pennanen, Tia M; Lindeberg, Heli; Mononen, Jaakko; Vepsäläinen, Jouko; Hujo, Mika; Viitala, Sari, 2025, Animal reproduction science, 281, 107973. A1 Journal article (refereed), original research -
17O NMR spectroscopy protocol for the determination of water content in liquids produced by pyrolysis and hydrothermal liquefaction
Jokinen, Noora; Eronen, Eemeli; Vepsäläinen, Jouko; Jänis, Janne; Lappalainen, Reijo; Tomppo, Laura; Tynkkynen, Tuulia, 2024, Analytica chimica acta, 1329, 343188. A1 Journal article (refereed), original research -
Catalytic action of hydronium-ion in rice straw pretreatment and enhancement of enzymatic hydrolysis and ethanol production
Manna, Dinabandhu; Chowdhury, Ranjana; Hassan, Md. Kamrul; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari, 2024, Next energy, 3, 100112. A1 Journal article (refereed), original research -
Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses
Rajamäki, Anni; Lehtovirta, Lari; Niemeläinen, Mika; Reito, Aleksi; Parkkinen, Jyrki; Peräniemi, Sirpa; Vepsäläinen, Jouko; Eskelinen, Antti, 2024, Bone joint research, 13, 4, 149-156, . A1 Journal article (refereed), original research -
Scent Detection Threshold of Trained Dogs to Eucalyptus Hydrolat
Turunen, Soile; Paavilainen, Susanna; Vepsäläinen, Jouko; Hielm-Björkman, Anna, 2024, Animals, 14, 7, 1083. A1 Journal article (refereed), original research -
Farmaseuttinen kemia
Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo, 2023, Publications of the University of Eastern Finland : general series, 44, 32-35, . E1 Popularised article, newspaper article -
Mikromuovien analytiikan ja poistomenetelmien kehittäminen teollisuuden laadunvalvontaan
Raninen, Kaisa; Uurasjärvi, Emilia; Peräniemi, Sirpa; Soininen, Tuomo; Vepsäläinen, Jouko; Järvelä, Essi; Riekkinen, Kati; Karim, Shahina; Selenius, Mikko; Savolainen, Ritva; Visuri, Roosa; Koistinen, Arto; Tomppo, Laura, 2023, Itä-Suomen yliopisto. D4 Published development or research report or study -
Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia
Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia, 2023, Metabolites, 13, 2, 233. A2 Review article, Literature review, Systematic review -
Syljen metabolomiikan sovellutuksia suulääketieteellisessä tutkimuksessa
Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia, 2023, Suomen hammaslääkärilehti, 30, 10, 27, . D1 Article in a trade journal -
Valorization potential of the aqueous products from hydrothermal liquefaction and stepwise slow pyrolysis of wood bark and hemp hurds with yields and product comparison
Jokinen, Noora; Eronen, Eemeli; Salami, Ayobami; Hyttinen, Marko; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo; Tomppo, Laura, 2023, Bioresource technology reports, 21, 101385. A1 Journal article (refereed), original research -
Effects of tree harvesting time and tannin cold/hot-water extraction procedures on the performance of spruce tannin biocoagulant for water treatment
Bello, Adedayo; Bergmann, Ulrich; Vepsäläinen, Jouko; Leiviskä, Tiina, 2022, Chemical engineering journal, 449, 137809. A1 Journal article (refereed), original research -
Functionalized nanoporous silicon for extraction of Sc from a leach solution
Rahmani, Arezoo; Thapa, Rinez; Aalto, Juha Matti; Turhanen, Petri; Vepsäläinen, Jouko; Lehto, Vesa Pekka; Riikonen, Joakim, 2022, Hydrometallurgy, 211, 105866. A1 Journal article (refereed), original research -
Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X-ray Fluorescence (pXRF) System
Tiihonen, Tommi E; Nissinen, Tuomo J; Turhanen, Petri A; Vepsäläinen, Jouko J; Riikonen, Joakim; Lehto, Vesa Pekka, 2022, Analytical chemistry, 94, 34, 11739-11744, . A1 Journal article (refereed), original research -
Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions
Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R., 2022, International journal of molecular sciences, 23, 9, 4614. A1 Journal article (refereed), original research -
α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation
Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A, 2021, Biomolecules, 11, 5, 707, . A1 Journal article (refereed), original research -
A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots
Salami, Ayobami; Heikkinen, Jorma; Tomppo, Laura; Hyttinen, Marko; Kekäläinen, Timo; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo, 2021, Molecules, 26, 11, 3167, . A1 Journal article (refereed), original research -
Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture
Kuittinen, Suvi; Hietaharju, Jenna; Kupiainen, Laura; Hassan, Md. Kamrul; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Kangas, Jani; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari, 2021, Journal of cleaner production, 293, 126088, . A1 Journal article (refereed), original research -
Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria
Virpiranta, Hanna; Taskila, Sanna; Leiviskä, Tiina; Vepsäläinen, Jouko; Rämö, Jaakko; Tanskanen, Juha, 2021, Journal of water and climate change, 12, 8, 3544-3557, . A1 Journal article (refereed), original research -
Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel
Nissinen, Samuli I; Venäläinen, Markus; Kumpulainen, Pekka; Roine, Antti; Häkkinen, Merja R; Vepsäläinen, Jouko; Oksala, Niku; Rantanen, Tuomo, 2021, Cancer control, 29, 1-9, . A1 Journal article (refereed), original research -
Effect of solvent mixture pretreatment on sugar release from short-rotation coppice Salix schwerinii for biobutanol production
Yang, Ming; Guo, Xiaojun; Liu, Guozhen; Nan, Yufei; Zhang, Junhua; Noyazzesh, Hossain; Kuittinen, Suvi; Vepsäläinen, Jouko; Pappinen, Ari, 2021, Bioresource technology, 344, Part B, 126262, . A1 Journal article (refereed), original research -
Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus
Lehtiniemi, Maiju; Hartikainen, Samuel; Turja, Raisa; Lehtonen, Kari K.; Vepsäläinen, Jouko; Peräniemi, Sirpa; Leskinen, Jari; Setälä, Outi, 2021, Marine pollution bulletin, 173, Part B, 113103, . A1 Journal article (refereed), original research -
Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds
Verkasalo, Erkki; Möttönen, Veikko; Roitto, Marja; Vepsäläinen, Jouko; Kumar, Anuj; Ilvesniemi, Hannu; Siwale, Workson; Julkunen-Tiitto, Riitta; Raatikainen, Olavi; Sikanen, Lauri, 2021, Forests, 12, 2, 192, . A1 Journal article (refereed), original research -
Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption
Haluska, Ondrej; Rahmani, Arezoo; Salami, Ayobami; Turhanen, Petri; Vepsäläinen, Jouko; Lappalainen, Reijo; Lehto, Vesa-Pekka; Riikonen, Joakim, 2021, Microporous and mesoporous materials, 324, 111294, . A1 Journal article (refereed), original research -
Recovery of uranium with bisphosphonate modified mesoporous silicon
Thapa, Rinez; Rahmani, Arezoo; Turhanen, Petri; Taskinen, Antti; Nissinen, Tuomo; Neitola, Raisa; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim, 2021, Separation and purification technology, 272, 118913, . A1 Journal article (refereed), original research -
Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms
Hagner, Marleena; Räty, Mari; Nikama, Johanna; Rasa, Kimmo; Peltonen, Sari; Vepsäläinen, Jouko; Keskinen, Riikka, 2021, Science of the total environment, 784, 147139, . A1 Journal article (refereed), original research -
Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams
Sandar, Sandra; Yang, Ming; Turunen, Ossi; Vepsäläinen, Jouko; Pappinen, Ari; Kuittinen, Suvi, 2020, Bioresources, 15, 4, 9265-9290, . A1 Journal article (refereed), original research -
Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing
Salami, Ayobami; Raninen, Kaisa; Heikkinen, Jorma; Tomppo, Laura; Vilppo, Teemu; Selenius, Mikko; Raatikainen, Olavi; Lappalainen, Reijo; Vepsäläinen, Jouko, 2020, Industrial crops and products, 155, 112760, . A1 Journal article (refereed), original research -
Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process
Salami, A; Vilppo, T; Pitkänen, S; Weisell, J; Raninen, K; Vepsäläinen, J; Lappalainen, R, 2020, Scientific African, 8, 1-13, . A1 Journal article (refereed), original research -
Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent
Szlachta, Malgorzata; Neitola, Raisa; Peräniemi, Sirpa; Vepsäläinen, Jouko, 2020, Separation and purification technology, 253, 117493, . A1 Journal article (refereed), original research -
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group
De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsäläinen, Jouko; Khomutov, Alex, 2020, Communications chemistry, 3, 1, 121, . A1 Journal article (refereed), original research -
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex, 2020, Biomolecules, 10, 3, 406, . A1 Journal article (refereed), original research -
Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum
Hagner, Marleena; Lindqvist, Bengt; Vepsäläinen, Jouko; Samorì, Chiara; Keskinen, Riikka; Rasa, Kimmo; Hyvönen, Terho, 2020, Environmental technology and innovation, 20, 101154, . A1 Journal article (refereed), original research -
Rapid synthesis of nanostructured porous silicon carbide from biogenic silica
Riikonen, Joakim; Rantanen, Jimi; Thapa, Rinez; Le, Nguyen T; Rigolet, Severinne; Fioux, Philippe; Turhanen, Petri; Bodiford, Nelli K; Kalluri, Jhansi R; lkonen, Timo; Nissinen, Tuomo; Lebeau, Benedicte; Vepsäläinen, Jouko; Coffer, Jeffery L; Lehto, Vesa-Pekka, 2020, Journal of the American Ceramic Society, 2021; 104, 2, 766-775, . A1 Journal article (refereed), original research -
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine
Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR, 2020, Russian journal of bioorganic chemistry, 46, 6, 686-692, . A1 Journal article (refereed), original research -
Bisphosphonate modified mesoporous silicon for scandium adsorption
Thapa, Rinez; Nissinen, Tuomo; Turhanen, Petri; Määttä, Juha; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim, 2019, Microporous and mesoporous materials, 2020; 296, 109980, . A1 Journal article (refereed), original research -
Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils
Mohsin, Muhammad; Kuittinen, Suvi; Abdus Salam, Mir Md; Peräniemi, Sirpa; Laine, Saila; Pulkkinen, Pertti; Kaipiainen, Erik; Vepsäläinen, Jouko; Pappinen, Ari, 2019, Journal of geochemical exploration, 205, 106335, . A1 Journal article (refereed), original research -
Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation
Yang, Ming; Wang, Jia; Nan, Yufei; Zhang, Junhua; Li, Liyun; Liu, Guozhen; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari, 2019, Rsc advances, 9, 58, 33755-33760, . A1 Journal article (refereed), original research -
Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach
Turhanen, Petri; Leppänen, Jukka; Vepsäläinen, Jouko J, 2019, ACS omega, 4, 5, 8974-8984, . A1 Journal article (refereed), original research -
Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti
Turunen, Kaisa; Antikainen, Eero; Huotari-Halkosaari, Taija; Ikonen, Jenni; Janhunen, Maarit; Lahtinen, Tatu; Lerssi, Jouni; Miettinen, Ilkka; Meriläinen, Päivi; Niittynen, Marjo; Pullinen, Arto; Reijonen, Tero; Raatikainen, Mika; Sonninen, Jari; Torvinen, Olli; Vauhkonen, Marko; Vepsäläinen, Jouko, 2019, . D4 Published development or research report or study -
Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics
Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M, 2019, International journal of epidemiology, 48, 3, 978-993, . A1 Journal article (refereed), original research -
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R, 2019, Journal of medicinal chemistry, 62, 24, 11335-11347, . A1 Journal article (refereed), original research -
Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf
Kuittinen, Suvi; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari, 2018, Bioresources, 13, 3, 5225-5240, . A1 Journal article (refereed), original research -
Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase
Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R, 2018, Mendeleev communications, 28, 5, 479-481, . A1 Journal article (refereed), original research -
Altered polyamine profiles in colorectal cancer
Venäläinen, Markus K; Roine, Antti N; Häkkinen, Merja R; Vepsäläinen, Jouko J; Kumpulainen, Pekka S; Kiviniemi, Mikko S; Lehtimäki, Terho; Oksala, Niku K; Rantanen, Tuomo K, 2018, Anticancer research, 38, 6, 3601-3607, . A1 Journal article (refereed), original research -
Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement
Lehtovirta, L; Reito, A; Parkkinen, J; Peräniemi, S; Vepsäläinen, J; Eskelinen, A, 2018, PLoS ONE, 13, 5, e0197614, . A1 Journal article (refereed), original research -
Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration
Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T, 2018, Biochemical journal, 475, 3, 663-676, . A1 Journal article (refereed), original research -
Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators
Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko, 2018, Bioscience reports, 38, 4, BSR20180527, . A1 Journal article (refereed), original research -
Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production
Yang, Ming; Xu, Minyuan; Nan, Yufei; Kuittinen, Suvi; Hassan, Md Kamrul; Vepsäläinen, Jouko; Xin, Donglin; Zhang, Junhua; Pappinen, Ari, 2018, Bioresource technology, 257, 113-120, . A1 Journal article (refereed), original research -
Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement
Yang Ming, Kuittinen Suvi, Vepsäläinen Jouko, Zhang Junhua, Pappinen Ari, 2017, Bioresource technology, 243, 126-134, . A1 Journal article (refereed), original research -
On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge
Khomich OA, Yanvarev DV, Novikov RA, Kornev AB, Puljulla E, Vepsäläinen J, Khomutov AR, Kochetkov SN, 2017, Molecules, 22, 7, e1040, . A1 Journal article (refereed), original research -
Urinary Polyamines as Biomarkers for Ovarian Cancer
Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U, 2017, International journal of gynecological cancer, 27, 7, 1360-1366, . A1 Journal article (refereed), original research -
Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids
Khomutov MA, Formanovsky AA, Mikhura IV, Vepsäläinen Jouko, Kochetkov SN, De Biase D, Khomutov AR, 2016, Russian journal of bioorganic chemistry, 42, 6, 672-676, . A1 Journal article (refereed), original research -
Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase
Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN, 2016, Data in brief, 8, 1157-1167, . A1 Journal article (refereed), original research -
Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity
Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN, 2016, Biochimie, 127, 153-162, . A1 Journal article (refereed), original research -
Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase
Khomutov MA, Simonian AR, Weisell J, Vepsäläinen J, Kochetkov SN, 2016, Russian journal of bioorganic chemistry, 42, 4, 415-422, . A1 Journal article (refereed), original research -
Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach
Turhanen Petri, Vepsäläinen Jouko, 2016, Rsc advances, 6, 15937-15940, . A1 Journal article (refereed), original research -
Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite
Puljula Elina, Vepsäläinen Jouko, Turhanen Petri, 2016, Beilstein journal of organic chemistry, 12, 2145-2149, . A1 Journal article (refereed), original research -
Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation
Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A, 2016, Biochemical journal, 473, 10, 1433-1441, . A1 Journal article (refereed), original research -
A powerful tool for acid catalyzed organic addition and substitution reactions
Turhanen Petri, Vepsäläinen Jouko, 2015, Rsc advances, 5, 26218-26222, . A1 Journal article (refereed), original research -
Advanced material and approach for metal ions removal from aqueous solutions
Turhanen Petri A, Vepsäläinen Jouko J, Peräniemi Sirpa, 2015, Scientific reports, 5, 8992, . A1 Journal article (refereed), original research -
Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid
Laakso Mikko P, Jukarainen Niko M, Vepsäläinen Jouko, 2015, Journal of neurology neurosurgery and psychiatry, 86, 12, 1286-1290, . A1 Journal article (refereed), original research -
Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport
Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, 2015, Acs chemical biology, 10, 6, 1417-1424, . A1 Journal article (refereed), original research -
Enantioselective synthesis of (R)- and (S)-3-methylspermidines
Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR, 2015, Russian journal of bioorganic chemistry, 41, 5, 548-553, . A1 Journal article (refereed), original research -
Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation
Yang Ming, Zhang Junhua, Kuittinen Suvi, Vepsäläinen Jouko, Soininen Pasi, Keinänen Markku, Pappinen Ari, 2015, Bioresource technology, 189, 131-137, . A1 Journal article (refereed), original research -
In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna, 2015, Chemical research in toxicology, 28, 4, 702-710, . A1 Journal article (refereed), original research -
Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives
Ucal Sebahat, Khomutov Alex R, Häkkinen Merja R, Turhanen Petri A, Vepsäläinen Jouko J, Weisell Janne, 2015, Arkivoc, 2015, 7, 42-49, . A1 Journal article (refereed), original research -
Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters
Puljula Elina, Turhanen Petri, Vepsäläinen Jouko, Monteil Maelle, Lecouvey Marc, Weisell Janne, 2015, Acs medicinal chemistry letters, 6, 4, 397-401, . A1 Journal article (refereed), original research -
Synthesis of biologically active analogues of spermine and spermidine
Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R., 2015, Amino acids. -
Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
Weisell Janne, Vepsäläinen Jouko, Turhanen Petri A, 2015, Beilstein journal of organic chemistry, 11, 2189-2193, . A1 Journal article (refereed), original research -
Urinary acetylated polyamines in ovarian cancer
Mäenpää Johanna Unelma, Niemi Riikka, Roine Antti, Häkkinen Merja, Kumpulainen Pekka, Keinänen Tuomo, Vepsäläinen Jouko, Lehtimäki Terho, Oksala Niku, 2015, Journal of clinical oncology. -
Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence
Castro-Oropeza R, Pino-Ángeles A, Khomutov MA, Urdiales JL, Moya-García AA, Vepsäläinen J, Persson L, Sarabia F, Khomutov A, Sánchez-Jiménez F, 2014, Amino acids, 46, 621-631, . A1 Journal article (refereed), original research -
Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques
Julkunen-Tiitto Riitta, Nenadis Nikolaos, Neugart Susanne, Robson Matthew, Agati Giovanni, Vepsäläinen Jouko, Zipoli Gaetano, Nybakken Line, Winkler Barbro, Jansen Marcel AK, 2014, Phytochemistry reviews, 2015; 14, 2, 273-297, . A2 Review article, Literature review, Systematic review -
Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production
Yang Ming, Kuittinen Suvi, Zhang Junhua, Vepsäläinen Jouko, Keinänen Markku, Pappinen Ari, 2014, Bioresource technology, 2015; 179, 128-135, . A1 Journal article (refereed), original research -
Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study
Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K, 2014, Journal of urology, 192, 230-235, . A1 Journal article (refereed), original research -
Eletroninen nenä havaitsee eturauhassyövän virtsasta [Detection of prostate cancer by an eletronic nose: a proof-of-principle study. J Urol, julkaistu verkossa 25.2.2014]
Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K, 2014, Duodecim, 130, 53, . B1 Non-refereed journal articles -
Hydroxylamine derivatives for regulation of spermine and spermidine metabolism
Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN, 2014, Biochemistry: moscow, 2013; 78, 13, 1431-1446, . A2 Review article, Literature review, Systematic review -
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku, 2014, Chemical research in toxicology, 27, 1950-1957, . A1 Journal article (refereed), original research -
Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J, 2014, Phytochemical analysis, 25, 220-228, . A1 Journal article (refereed), original research -
Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J, 2014, Food chemistry, 165, 499-505, . A1 Journal article (refereed), original research -
Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme
Keinanen TA, Hyvonen T, Vepsalainen J, Alhonen L, Khomutov AR, Janne J, 2014, Russian journal of bioorganic chemistry, 40, 155-161, . A1 Journal article (refereed), original research -
The use of (green field) biomass pretreatment liquor for fermentative butanol production and the catalytic oxidation of biobutanol
Yang Ming, Kuittinen Suvi, Keinänen Markku, Vepsäläinen Jouko, Romar Henrik, Tynjälä Pekka, Lassi Ulla, Pappinen Ari, 2014, Chemical engineering research and design, 92, 8, 1531-1538, . A1 Journal article (refereed), original research -
Uraanin ja muiden raskasmetallien poistaminen vedestä
Vepsäläinen Jouko, 2014, Ympäristö ja terveys, 45, 2, 72-76, . D1 Article in a trade journal -
A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens
Alanne Aino-Liisa, Peräniemi Sirpa, Turhanen Petri, Tuomainen Marjo, Vepsäläinen Jouko, Tervahauta Arja, 2013, Chemosphere, 2014:95, 566-571, . A1 Journal article (refereed), original research -
A novel bisphosphonate-based solid phase method for effective removal of chromium(III) from aqueous solutions and tannery effluents
Alanne Aino-Liisa, Tuikka Matti, Tõnsuaadu Kaia, Ylisirniö Markku, Hämäläinen Lea, Turhanen Petri, Vepsäläinen Jouko, Peräniemi Sirpa, 2013, Rsc advances, 3, 14132-14138, . A1 Journal article (refereed), original research -
Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS
Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko, 2013, Journal of chromatography b: analytical technologies in the biomedical and life sciences, 941, 81-89, . A1 Journal article (refereed), original research -
Charge deficient analogues of the natural polyamines
Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R, 2013, Current pharmaceutical design, 2014:20, 2, 262-277, . A2 Review article, Literature review, Systematic review -
Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin
Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko, 2013, European journal of pharmaceutical sciences, 49, 624-628, . A1 Journal article (refereed), original research -
First bisphosphonate hydrogelators: potential composers of biocompatible gels
Alanne Aino-Liisa, Lahtinen Manu, Löfman Miika, Turhanen Petri, Kolehmainen Erkki, Vepsäläinen Jouko, Sievänen Elina, 2013, Journal of materials chemistry. b, 1, 6201-6212, . A1 Journal article (refereed), original research -
Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity
Meinander Kristian, Weisell Janne, Pakkala Miikka, Tadd Andrew C, Hekim Can, Kallionpää Roope, Widell Kim, Stenman Ulf-Håkan, Koistinen Hannu, Närvänen Ale, Vepsäläinen Jouko, Luthman Kristina, Wallén Erik AA, 2013, Medchemcomm, 4, 549-553, . A1 Journal article (refereed), original research -
Selective regulation of polyamine metabolism with methylated polyamine analogues
Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, 2013, Amino acids, 2014:46, 605-620, . A2 Review article, Literature review, Systematic review -
Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives
Agapkina Julia, Yanvarev Dmitry, Anisenko Andrey, Korolev Sergey, Vepsäläinen Jouko, Kochetkov Sergey, Gottikh Marina, 2013, European journal of medicinal chemistry, 2014:73, 73-82, . A1 Journal article (refereed), original research -
Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A
Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A, 2013, Biochemical journal, 453, 467-474, . A1 Journal article (refereed), original research -
Tautomeric populations of the charged species of 1,12-diamino-3,6,9-triazadodecane (SpmTrien) studied with computer simulations and cluster expansions
Weisell Janne, Vepsäläinen Jouko, Peräkylä Mikael, 2013, Journal of physical organic chemistry, 26, 360-366, . A1 Journal article (refereed), original research -
The selective stepwise chemical hydrolysis of alkylcarbonate groups from novel mixed alkylcarbonate trialkyl ester derivatives of etidronic acid
Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J, 2013, Rsc advances, 3, 2417-2421, . A1 Journal article (refereed), original research -
Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells
Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V, 2012, Biochimie, 94, 9, 1876-1883, . A1 Journal article (refereed), original research -
Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose
Roine Antti, Tolvanen Mikko, Sipiläinen Miki, Kumpulainen Pekka, Helenius Merja A, Lehtimäki Terho, Vepsäläinen Jouko, Keinänen Tuomo A, Häkkinen Merja R, Koskimäki Juha, Veskimäe Erik, Tuokko Antti, Visakorpi Tapio, Tammela Teuvo L, Sioris Thanos, Paavonen Timo, Lekkala Jukka, Helle Hannu, Oksala Niku K, 2012, Future oncology, 8, 9, 1157-1165, . A1 Journal article (refereed), original research -
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A
Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H, 2012, Amino acids, 42, 685-695, . A1 Journal article (refereed), original research -
In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin
Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko, 2012, Journal of pharmaceutical sciences, 101, 8, 2854-2860, . A1 Journal article (refereed), original research -
Metabolism of bilirubin by human cytochrome P450 2A6
Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A, 2012, Toxicology and applied pharmacology, 261, 50-58, . A1 Journal article (refereed), original research -
Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase
Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, 2012, Drug metabolism and disposition, 2013:41, 30-32, . A1 Journal article (refereed), original research -
Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS
Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A, 2012, Amino acids, 42, 451-460, . A1 Journal article (refereed), original research -
Preparation of mixed trialkyl alkylcarbonate derivates of etidronic acid via an unusual route
Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J, 2012, Beilstein journal of organic chemistry, 8, 2019-2024, . A1 Journal article (refereed), original research -
Synthesis of novel bisphosphonate polyamine conjugates and their affinity to hydroxyapatite
Sankala Elina, Weisell Janne M, Huhtala Tuulia, Närvänen Ale T.O, Vepsäläinen Jouko J, 2012, Arkivoc, 2012, 4, 233-241, . A1 Journal article (refereed), original research -
Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates
Alanne Aino-Liisa, Hyvönen Helena, Lahtinen Manu, Ylisirniö Markku, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko, 2012, Molecules, 17, 9, 10928-10945, . A1 Journal article (refereed), original research -
The combined use of constrained total-line-shape 1H NMR and LC-MS/MS for quantitative analysis of bioactive components in yellow onion
Soininen Tuula H, Jukarainen Niko, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J, 2012, Journal of food composition and analysis, 25, 208-214, . A1 Journal article (refereed), original research -
Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase
Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena, 2012, Amino acids, 42, 485-493, . A1 Journal article (refereed), original research -
A novel strategy for the synthesis of enzymatically stable biotin-DOTA conjugates for in vivo use
Turhanen Petri A, Weisell Janne, Lehtolainen-Dalkilic Pauliina, Määttä Ann-Marie, Vepsäläinen Jouko, Närvänen Ale, 2011, Medchemcomm, 2, 2, 886-888, . A1 Journal article (refereed), original research -
Complex N-Acetylation of Triethylentetramine
Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen, 2011, Drug metabolism and disposition, 39, 12, 2242-2249, . A1 Journal article (refereed), original research -
Novel metabolically stable functionally active mimetic of spermidine
Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA, 2011, Russian journal of bioorganic chemistry, 37, 2, 253-258, . A1 Journal article (refereed), original research -
The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism
Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov, 2011, Journal of medicinal chemistry, 54, 13, 4611-4618, . A1 Journal article (refereed), original research -
A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids
Komissarov VV, Kritzyn AM & Vepsäläinen J, 2010, Beilstein journal of organic chemistry, 6, 63, 1-5, . A1 Journal article (refereed), original research -
Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis
Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L, 2010, Pancreatology, 10, 208-221, . A1 Journal article (refereed), original research -
Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products
Kunnas-Hiltunen S, Haukka M, Vepsäläinen JJ & Ahlgrén M, 2010, Dalton transactions, 39, 5310-5318, . A1 Journal article (refereed), original research -
DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage
Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ, 2010, Biomacromolecules, 11, 97-105, . A1 Journal article (refereed), original research -
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T, 2010, Amino acids, 38, 369-381, . A1 Journal article (refereed), original research -
Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3 stimulating peptide B-2.
Pakkala M, Weisell J, Hekim C, Vepsäläinen J, Wallen E, Stenman U-H, Koistinen H, Närvänen A., 2010, Amino acids, 39, 1, 233-236, . A1 Journal article (refereed), original research -
Novel convenient synthesis of biologically active esters of hydroxylamine
Maxim A. Khomutov, Swati Mandal, Janne Weisell, Neiha Saxena, Alina R. Simonian, Jouko Vepsalainen, Rentala Madhubala, Sergey N. Kochetkov, 2010, Amino acids, 38, 509-517, . A1 Journal article (refereed), original research -
Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity
Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P, 2010, Amino acids, 38, 2, 501-507, . A1 Journal article (refereed), original research -
Organic-Inorganic Hybrid Materials: Synthesis, X-ray Diffraction Study and Characterisations of Manganese, Coboalt and Copper Complexes of Modified Bis(phosphonates)
Kunnas-Hiltunen S, Laurila E, Haukka M, Vepsäläinen JJ & Ahlgrén M, 2010, Zeitschrift fur anorganische und allgemeine chemie, 636, 710-720, . A1 Journal article (refereed), original research -
Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues
Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al, 2010, Journal of medicinal chemistry, 53, 15, 5738-5748, . A1 Journal article (refereed), original research -
alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage
Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L, 2010, Amino acids, 38, 575-581, . A1 Journal article (refereed), original research -
Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography
Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P, 2009, Journal of pharmaceutical and biomedical analysis, 50, 469-474, . A1 Journal article (refereed), original research -
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues
Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA, 2009, Biochemical journal, 422, 321-328, . A1 Journal article (refereed), original research -
Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism
Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J, 2009, MOLEKULIARNAIA BIOLOGIIA [MOSKVA], 43, 2, 274-285, . A1 Journal article (refereed), original research -
Poly[(acetone)tetraaqua[my6-ethyl(dichloromethylene)diphosphonato]-[my5-ethyl (dichloromethylene)-diphosphonato]tribarium(II)]
Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section C : crystal structure communications, C65, m165-m167, . A1 Journal article (refereed), original research -
Poly[[my-aqua-aqua[myy4-ethyl(dichloromethylene)diphosphonato]sesquicalcium(II)] acetone hemisolvate 4.5-hydrate]
Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section E : structure reports online, E65, m436-m437, . A1 Journal article (refereed), original research -
Syntheses, X-ray diffraction study and characterisations of Ni an Zn complexes of clodronic acid and its dibenzoyl derivate
Kunnas-Hiltunen S, Haukka M, Vepsäläinen J, Ahlgrén M, 2009, European journal of inorganic chemistry, 5335-5345, . A1 Journal article (refereed), original research -
Synthesis of novel deuterium labelled derivates of N-alkylated polyamines
Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J, 2009, Tetrahedron, 65, 2, 547-562, . A1 Journal article (refereed), original research -
Synthesis of phenyl substituted bisphosphonates and crystal structures and characterization of Cd complexes of (dichloromethylene)bisphosphonic acid phenyl and alkyl ester derivatives
Jokiniemi J, Vepsäläinen J, Nätkinniemi H, Peräniemi S, Ahlgrén M, 2009, Crystengcomm, 11, 2431-2440, . A1 Journal article (refereed), original research -
The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption
Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J, 2009, Journal of medicinal chemistry, 52, 4142-4148, . A1 Journal article (refereed), original research -
X-ray diffraction study of bisphosphonate metal complexes: Mg, Sr and Ba complexes of (dichloromethylene)bisphosphonic acid P,P'-dibenzoyl anhydride
Kunnas-Hiltunen S, Matilainen M, Vepsäläinen JJ, Ahlgrén M, 2009, Polyhedron, 28, 200-204, . A1 Journal article (refereed), original research -
catena-Poly[[diaquacadmium(II)]-mu-(methyl morpholino dicholromethylene-disphosphonato)-kappa3O,O':O''-[tetraaqua-cadmium(II)-mu-(methyl morpholino dichloromethylenediphosphonato)-kappa3O:O',O'']
Jokiniemi J, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section E : structure reports online, E65, M600-M601, . A1 Journal article (refereed), original research -
A structural study of alkaline earth metal complexes of (dicholoromethylene)bisphosphonic acid P-morpholinium- and P-pyrrolidinium-P'-methyl esters
Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2008, Crystengcomm, 10, 1011-1017, . A1 Journal article (refereed), original research -
Ex vivo evaluation of N(3-[18F]fluoroproponyl9-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane in rats
Koivula T, Marjamäki P, Haaparanta M, Fagerholm V, Grönroos T, Lipponen T, Perhola O, Vepsäläinen J, Solin O, 2008, Nuclear medicine and biology, 35, 177-183, . A1 Journal article (refereed), original research -
Novel agmatine analogue, gamma-quanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels
Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R, 2008, Biochemical and biophysical research communications, 375, 168-172, . A1 Journal article (refereed), original research -
Quantification of 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis
Jukarainen NM, Korhonen S-P, Laakso MP, Korolainen MA, Niemitz M, Soininen PP, Tuppurainen K, Vepsäläinen J, Pirttilä T, Laatikainen R, Pirttilä T, 2008, Metabolomics, 4, 150-160, . A1 Journal article (refereed), original research -
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S, 2008, Journal of pharmaceutical and biomedical analysis, 48, 414-421, . A1 Journal article (refereed), original research -
Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol
Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J, 2008, European journal of pharmaceutical sciences, 34, 110-117, . A1 Journal article (refereed), original research -
Towards metformin prodrugs
Huttunen KM, Leppänen J, Kemppainen E, Palonen P, Rautio J, Järvinen T, Vepsäläinen J, 2008, Synthesis: stuttgart, 22, 3619-3624, . A1 Journal article (refereed), original research -
Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions
Turhanen PA, Vepsäläinen JJ, 2008, Beilstein journal of organic chemistry, 4, 7, . A1 Journal article (refereed), original research -
2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors
Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JAM, Forsberg MM, Männistö PT, Wallén EAA, 2007, Bioorganic and medicinal chemistry, 15, 2024-2031, . A1 Journal article (refereed), original research -
A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterfied derivatives
Turhanen PA, Demadis KD, Peräniemi S, Vepsäläinen JJ, 2007, Journal of organic chemistry, 72, 4, 1468-1471, . A1 Journal article (refereed), original research -
Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors
Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman U-H, Vepsäläinen J, Närväinen A, 2007, Journal of peptide science, 13, 348-353, . A1 Journal article (refereed), original research -
Alpha-methylated polyamines as potential drugs and experimental tools in enzymology
Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J, 2007, Mini-reviews in medicinal chemistry, 7, 8, 813-820, . A1 Journal article (refereed), original research -
Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S, 2007, Journal of pharmaceutical and biomedical analysis, 45, 625-634, . A1 Journal article (refereed), original research -
Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase
Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J, 2007, Nucleosides nucleotides and nucleic acids, 26, 1245-1248, . A1 Journal article (refereed), original research -
Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality
Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J, 2007, Pharmaceutical research, 24, 4, 679-687, . A1 Journal article (refereed), original research -
Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis
Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L, 2007, Amino acids, 33, 2, 323-330, . A1 Journal article (refereed), original research -
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis
Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, 2007, Journal of biological chemistry, 282, 48, 34700-34706, . A1 Journal article (refereed), original research -
Structural study of metal complexes of bisphosphonate amide ester: copper, magnesium, zinc and cadmium complexes of (dichloromethylene)bisphosphonic acid P-piperidinium-P¿-methyl ester
Jokiniemi J, Vuokila-Laine E, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2007, Crystengcomm, 9, 158-164, . A1 Journal article (refereed), original research -
Synthesis of novel optical isomers of [alpha]-methylpolyamines
Grigorenko NA, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J, 2007, Tetrahedron, 63, 2257-2262, . A1 Journal article (refereed), original research -
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J, 2006, British journal of pharmacology, 147, 437-445, . A1 Journal article (refereed), original research -
A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts
Holappa J, Nevalainen T, Safin R, Vepsäläinen J, Järvinen T, 2006, Tetrahedron letters, 47, 323-325, . A1 Journal article (refereed), original research -
Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality
Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L, 2006, American journal of pathology, 168, 115-122, . A1 Journal article (refereed), original research -
Alfa-methyl polyamines: efficient synthesis and tolerance studies in vivo and vitro. First evidence for dormant stereospecificity of polyamine oxidase
Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE, 2006, Journal of medicinal chemistry, 49, 399-406, . A1 Journal article (refereed), original research -
Aminooxy analogues of spermine and their monoacetyl derivatives
Simonyan AR, Vepsalainen J, Khomutov AR, 2006, Russian journal of bioorganic chemistry, 32, 6, 578-585, . A1 Journal article (refereed), original research -
An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors
Jarho EM, Venäläinen J, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JAM, Forsberg MM, Järvinen T, Männistö PT, Wallén EAA, 2006, Bioorganic and medicinal chemistry letters, 16, 5590-5593, . A1 Journal article (refereed), original research -
Controlling the regio- and stereospecifity of enzyme catalysis with guide molecules
Keinänen T, Järvinen A, Vepsäläinen J, Uimari A, Alhonen L, Jänne J, 2006, . H1 Granted patent -
Convenient microwave-assisted synthesis of 1-chloroethyl phosphates
Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J, 2006, CHEMINFORM, 37, 26, . A1 Journal article (refereed), original research -
Efficient strategy to prepare water-soluble prodrugs of ketones
Huttunen KM, Kumpulainen H, Leppänen J, Rautio J, Järvinen T, Vepsäläinen J, 2006, Synlett, 5, 701-704, . A1 Journal article (refereed), original research -
Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure
Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J, 2006, Journal of medicinal chemistry, 49, 1207-1211, . A1 Journal article (refereed), original research -
Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase
Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J, 2006, Journal of biological chemistry, 281, 8, 4589-4595, . A1 Journal article (refereed), original research -
Novel one-pot synthesis of amide derivatives of methylenebisphosphonate utilizing the mesyl moiety as leaving group
Jokiniemi J, Ahlgrén M, Vepsäläinen JJ, 2006, Letters in organic chemistry, 3, 12, 898-900, . A1 Journal article (refereed), original research -
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists
Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T, 2006, Journal of medicinal chemistry, 49, 2022-2027, . A1 Journal article (refereed), original research -
Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists
Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J, 2006, Chemical biology and drug design, 68, 6, 334-340, . A1 Journal article (refereed), original research -
Synthesis of novel (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives
Turhanen P, Vepsalainen JJ, 2006, Beilstein journal of organic chemistry, 2:2, . A1 Journal article (refereed), original research -
The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms
Lewandowicz AM, Vepsäläinen J, Laitinen JT, 2006, British journal of pharmacology, 147, 422-429, . A1 Journal article (refereed), original research -
A charge-deficient analogue of spermine with chelating properties
Khomutov AR, Grigorenko NA, Skuridin SG, Demin AV, Vepsalainen J, Casero RA, Woster PM, 2005, Russian journal of bioorganic chemistry, 31, 3, 271-278, . A1 Journal article (refereed), original research -
An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates
Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J, 2005, Journal of organic chemistry, 70, 9056-9058, . A1 Journal article (refereed), original research -
Catena-Poly[diaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O,O':O''-tetraaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O:O',O'']
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section C : crystal structure communications, E61, m635-m637, . A1 Journal article (refereed), original research -
Catena-poly[diaquacadmium(II)-my-(diethyl dichloromethylenebisphosphonato)-kappa3 O,O':O'' -tetraaquacadmium(II)-my -(diethyl dichloromethylenebisphosphonato-)kappa3 O:O',O'']
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section C : crystal structure communications, E61, m638-m640, . A1 Journal article (refereed), original research -
Catena-poly[diaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o,ó:o" -tetraaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o:ó,o"]
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section E : structure reports online, E61, m635-m637, . A1 Journal article (refereed), original research -
Isolation and characterization of yuremamine, a new phytoindole
Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC, 2005, Planta medica, 71, 1053-1057, . A1 Journal article (refereed), original research -
Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines
Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J, 2005, Journal of biological chemistry, 280, 8, 6595-6601, . A1 Journal article (refereed), original research -
New charge-deficient agmatine analogues
Simonyan AR, Grigorenko NA, Vepsalainen J, Khomutov AR, 2005, Russian journal of bioorganic chemistry, 31, 6, 583-587, . A1 Journal article (refereed), original research -
New oxaanalogues of spermine
Khomutov AR, Simonyan AR, Vepsalainen J, Keinanen TA, Alhonen L, Janne J, 2005, Russian journal of bioorganic chemistry, 31, 2, 189-195, . A1 Journal article (refereed), original research -
New syntheses of alfa-methyl- and alfa,alfa'-dimethylspermine
Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR, 2005, Russian journal of bioorganic chemistry, 31, 2, 183-188, . A1 Journal article (refereed), original research -
Polymethylene derivatives of nucleic bases with omega-functional groups: IV.1[7-(2-oxocyclohexyl)-7-oxoheptyl]purines
Kritzyn AM, Vepsalainen J, Komissarov VV, 2005, Russian journal of bioorganic chemistry, 31, 3, 256-262, . A1 Journal article (refereed), original research -
Simplified synthesis of N-(3-[18F]-fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)-nortropane([18F]beta-CFT-FP using [18F]fluoropropyl tosylate as the labelling reagent
Koivula T, Perhola O, Kämäräinen E-L, Lipponen T, Vepsäläinen J, Solin O, 2005, Journal of labelled compounds and radiopharmaceuticals, 48, 463-471, . A1 Journal article (refereed), original research -
Strategies for organic impurity quantification by 1H NMR spectroscopy: constrained total-line-shape fitting
Soininen P, Haarala J, Vepsäläinen J, Niemitz M, Laatikainen R, 2005, Analytica chimica acta, 542, 2, 178-185, . A1 Journal article (refereed), original research -
Structures of bisphosphonate metal complexes: zinc and cadmium complexes of clodronate and its partial ester derivatives
Kontturi M, Laurila E, Mattsson R, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Inorganic chemistry, 44, 2400-2406, . A1 Journal article (refereed), original research -
Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters
Airaksinen AJ, Huotari M, Shvetsov A, Vainiotalo P, Männisto PT, Tuomisto L, Bergström K, Vepsäläinen J, 2005, European journal of medicinal chemistry, 40, 3, 299-304, . A1 Journal article (refereed), original research -
Synthesis of (R)- and (S)-isomers of 1-methylspermidine
Grigorenko NA, Vepsalainen JJ, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR, 2005, Mendeleev communications, 15, 4, 142-143, . A1 Journal article (refereed), original research -
Synthesis of 9-[2-O-(2-methoxyethyl)-beta-D-ribofuranosyl]purines using 1-methanesulfonyloxy-2-methoxyethane
Sivets GG, Vepsäläinen J, Mikhailopulo IA, 2005, Letters in organic chemistry, 2, 343-348, . A1 Journal article (refereed), original research -
Synthesis of novel fatty acid derivatives of etidronic acid
Turhanen PA, Vepsäläinen JJ, 2005, Synthesis: stuttgart, 18, 3063-3066, . A1 Journal article (refereed), original research -
The first synthesis of novel (1-alkoxycarbonyloxyethylidene)-1,1-bisphosphonic acid derivatives taking advantage of the rearrangement characteristic of the tetramethyl ester of etidronate
Turhanen PA, Vepsäläinen JJ, 2005, Synthesis: stuttgart, 13, 2119-2121, . A1 Journal article (refereed), original research -
X-ray diffraction study of bisphosphonate metal complexes: Mg and Ca complexes of (dichloromethylene)bisphosphonic acid P,P'-diisopropyl ester
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Polyhedron, 24, 305-309, . A1 Journal article (refereed), original research -
3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L
Kalinichenko EN, Podkopaeva TL, Budko EV, Seela F, Dong B, Silverman R, Vepsäläinen J, Torrence PF, Mikhailopulo IA, 2004, Bioorganic and medicinal chemistry, 12, 3637-3647, . A1 Journal article (refereed), original research -
A structural study of bisphosphonate metal complexes - three new polymeric structures of the calcium complex of clodronic acid
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, European journal of inorganic chemistry, 2627-2631, . A1 Journal article (refereed), original research -
Conformational and biochemical analysis of the cyclic peptides which modulate serine protease activity
Pakkala M, Jylhäsalmi A, Wu P, Leinonen J, Stenman U-H, Santa H, Vepsäläinen J, Peräkylä M, Närvänen A, 2004, Journal of peptide science, 10, 439-447, . A1 Journal article (refereed), original research -
Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone
Mäntylä A, Rautio J, Nevalainen T, Keski-Rahkonen P, Vepsäläinen J, Järvinen T, 2004, European journal of pharmaceutical sciences, 23, 151-158, . A1 Journal article (refereed), original research -
Effects of triaryl phosphates on mouse and human nuclear receptors
Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S, 2004, Biochemical pharmacology, 67, 97-106, . A1 Journal article (refereed), original research -
Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration
Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J, 2004, . H1 Granted patent -
Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration (in Japanese)
Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J, 2004, . H1 Granted patent -
One-pot synthesis of 1-[(1-phenyl-1-dialkoxyphosphoryl)-methyl]-2-pyrrolidinone
Turhanen PA, Soininen P, Vepsäläinen JJ, 2004, Letters in organic chemistry, 1, 343-345, . A1 Journal article (refereed), original research -
Pentaaqua (dichloromethylenebisphosphonato)strontium(II)
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, Acta crystallographica section C : crystal structure communications, E60, m1060-m1062, . A1 Journal article (refereed), original research -
Poly[[tetraaqua(my7-hydrogen dichloromethylenebisphosphonato)(my5-hydrogen dichloromethylenebisphosphonato)tribarium(II)] monohydrate)
Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, Acta crystallographica section C : crystal structure communications, C60, m592-m594, . A1 Journal article (refereed), original research -
Strategies for the preparation of (1-acetyloxyethylidene)-1,1-bisphosphonic acid derivatives
Turhanen PA, Vepsäläinen JJ, 2004, Synthesis: stuttgart, 7, 0992-0994, . A1 Journal article (refereed), original research -
Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives
Mäntylä A, Rautio J, Nevalainen T, Vepsälainen J, Juvonen R, Kendrick H, Garnier T, Croft SL, Järvinen T, 2004, Bioorganic and medicinal chemistry, 12, 3497-3502, . A1 Journal article (refereed), original research -
Synthesis of some mono-mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity
Gul HI, Calis U, Vepsäläinen J, 2004, Arzneimittel-forschung-drug research, 54, 7, 359-364, . A1 Journal article (refereed), original research -
Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone
Mäntylä A, Garnier T, Rautio J, Nevalainen T, Vepsäläinen J, Koskinen A, Croft SL, Järvinen T, 2004, Journal of medicinal chemistry, 47, 188-195, . A1 Journal article (refereed), original research -
Time-resolved growth behavior of acid aerosols in ethanol vapor with a tandem-DMA technique
Joutsensaari J, Toivonen T, Vaattovaara P, Vesterinen M, Vepsäläinen J, Laaksonen A, 2004, Journal of aerosol science, 35, 851-867, . A1 Journal article (refereed), original research -
Addition of tert-butylcuprate to (2S)-N-acyl-delta5-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2S,5S)-5-tert-butylproline
Wallén EAA, Christiaans JAM, Gynther J, Vepsäläinen J, 2003, Tetrahedron letters, 44, 2081-2082, . A1 Journal article (refereed), original research -
Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects
Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J, 2003, European journal of pharmaceutical sciences, 19, 23-29, . A1 Journal article (refereed), original research -
Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells
Gul HI, Gul M, Vepsälainen J, Erciyas E, Hänninen O, 2003, Biological and pharmaceutical bulletin, 26, 5, 631-637, . A1 Journal article (refereed), original research -
Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön
Järvinen T, Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, 2003, . H1 Granted patent -
First synthesis of etidronate partial amides starting from PCI3
Turhanen PA, Niemi R, Peräkylä M, Järvinen T, Vepsäläinen JJ, 2003, Organic and biomolecular chemistry, 1, 3223-3226, . A1 Journal article (refereed), original research -
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*
Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA, 2003, Journal of biological chemistry, 278, 46, 45915-45923, . A1 Journal article (refereed), original research -
Reduction of 6/7-substituted 3-phenyltrop-3-en-2-ones: stereoselectivity and conformational analysis of the products
Airaksinen AJ, Lipsonen J, Ahlgren M, Vainiotalo P, Bergström KA, Laatikainen R, Vepsäläinen J, 2003, Tetrahedron, 59, 377-383, . A1 Journal article (refereed), original research -
Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether
Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T, 2003, Journal of medicinal chemistry, 46, 5083-5086, . A1 Journal article (refereed), original research -
A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates
Mäntylä A, Vepsäläinen J, Järvinen T, Nevalainen T, 2002, Tetrahedron letters, 43, 3793-3794, . A1 Journal article (refereed), original research -
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism
Räsänen T-L, Alhonen L, Sinervirta R, Keinänen T, Herzig K-H, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J, 2002, Journal of biological chemistry, 277, 42, 39867-39872, . A1 Journal article (refereed), original research -
A structural study of bisphosphonate metal complexes. Alkaline earth metal complexes of (dichloromethylene)bisphosphonic acid P,P' -diethyl ester
Kontturi M, Vuokila-Laine E, Peräniemi S, Pakkanen TT, Vepsäläinen JJ, Ahlgrén M, 2002, JOURNAL OF THE CHEMICAL SOCIETY. DALTON TRANSACTIONS, 1969-1973, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs
Vepsäläinen JJ, 2002, Current medicinal chemistry, 9, 1075-1085, . A1 Journal article (refereed), original research -
One-pot synthesis of 3,4-disubstituted 1H-pyrroles from 2-tropanones
Airaksinen AJ, Ahlgren M, Vepsäläinen J, 2002, Journal of organic chemistry, 67, 5019-5021, . A1 Journal article (refereed), original research -
Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2a-(imino-methyl)-3b-(3',4'-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter
Yu M, Airaksinen AJ, Gee AD, Lötjönen S, Kuikka JT, Vepsäläinen JJ, Hiltunen J, Bergström KA, 2002, Journal of labelled compounds and radiopharmaceuticals, 45, 1011-1017, . A1 Journal article (refereed), original research -
Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols
Gul HI, Calis U, Vepsalainen J, 2002, Arzneimittel-forschung-drug research, 52, 12, 863-869, . A1 Journal article (refereed), original research -
Synthesis of anhydro psicofuranosyl nucleosides
Roivainen J, Vepsäläinen J, Azhayev A, Mikhailopulo IA, 2002, Tetrahedron letters, 43, 6553-6555, . A1 Journal article (refereed), original research -
Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone
Gul HI, Ojanen T, Vepsalainen J, Gul M, Erciyas E, Hanninen O, 2001, Arzneimittel-forschung-drug research, I, 51, 72-75, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and X-ray crystallography
Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen JJ, 2001, PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS, 170, 115-133, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs: selective synthesis of (1-hydroxyethylidene)-1,1-bisphosphonate partial esters
Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen J, 2001, Synthesis: stuttgart, 4, 633-637, . A1 Journal article (refereed), original research -
Effect of acetophenone derived Mannich bases on cellular glutathione level in Jurkat cells
Gul M, Gul HI, Vepsalainen J, Erciyas E, Hanninen O, 2001, Arzneimittel-forschung-drug research, 51, II, 679-682, . A1 Journal article (refereed), original research -
Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells
Raiman J, Niemi R, Vepsäläinen J, Yritys K, Järvinen T, Mönkkönen J, 2001, International journal of pharmaceutics, 213, 135-142, . A1 Journal article (refereed), original research -
Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography
Tupala E, Kuikka JT, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Hiltunen J, Vepsäläinen J, Tiihonen J, 2001, Neuroimage, 14, 87-94, . A1 Journal article (refereed), original research -
Novel acid-free cleavage of N-(2-hydroxyarylidene) protected amines
Khomutov AR, Shvetsov AS, Vepsäläinen JJ, Kritzyn AM, 2001, Tetrahedron letters, 42, 2887-2889, . A1 Journal article (refereed), original research -
A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations
Kovalainen JT, Christiaans JAM, Ropponen R, Poso A, Peräkylä M, Vepsäläinen J, Laatikainen R, Gynther J, 2000, Journal of the American Chemical Society, 122, 29, 6989-6996, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs: synthesis and vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate
Niemi R, Turhanen P, Vepsäläinen J, Taipale H, Järvinen T, 2000, European journal of pharmaceutical sciences, 11, 173-180, . A1 Journal article (refereed), original research -
Conformational flexibility and role of aromatic-aromatic interactions in the crystal packing of the coordination compounds of some novel quadridentate Schiff bases
Pulkkinen JT, Laatikainen R, Ahlgrén MJ, Peräkylä M, Vepsäläinen JJ, 2000, JOURNAL OF THE CHEMICAL SOCIETY. PERKIN 2, 2, 777-784, . A1 Journal article (refereed), original research -
Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells
Gul HI, Vepsalainen J, Gul M, Erciyas E, Hanninen O, 2000, PHARMACEUTICA ACTA HELVETIAE, 74, 393-398, . A1 Journal article (refereed), original research -
Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties
Tennilä T, Azhayeva E, Vepsäläinen J, Laatikainen R, Azhayev A, Mikhailopulo IA, 2000, Nucleosides nucleotides and nucleic acids, 19, 10-12, 1861-1884, . A1 Journal article (refereed), original research -
Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, European journal of pharmaceutical sciences, 11, 157-163, . A1 Journal article (refereed), original research -
Preparation of (18F)beta-CFT-FP and (11C)beta-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)
Kämäräinen E-L, Kyllönen T, Airaksinen A, Lundkvist C, Yu M, Någren K, Sandell J, Langer O, Vepsäläinen J, Hiltunen J, Bergström K, Lötjönen S, Jaakkola T, Halldin C, 2000, Journal of labelled compounds and radiopharmaceuticals, 43, 1235-1244, . A1 Journal article (refereed), original research -
Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, Journal of medicinal chemistry, 43, 8, 1489-1494, . A1 Journal article (refereed), original research -
Synthesis of a water-soluble prodrug of entacapone
Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T, 2000, Bioorganic and medicinal chemistry letters, 10, 1967-1969, . A1 Journal article (refereed), original research -
Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters
Ahlmark MJ, Vepsäläinen JJ, 2000, Tetrahedron, 56, 5213-5219, . A1 Journal article (refereed), original research -
Uudet metyleenibisfosfonihappojohdannaiset
Pohjola EK, Vepsäläinen J, Nupponen H, Kähkönen JP, Lauren L, Hannuniemi R, Järvinen TL, Ahlmark MJ, 2000, . H1 Granted patent -
1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists
Kovalainen JT, Christiaans JAM, Poso A, Vepsäläinen J, Laatikainen R, Gynther J, 1999, Tetrahedron letters, 40, 2425-2428, . A1 Journal article (refereed), original research -
3rd Spring Meeting on the Division of Synthetic Chemistry Kuopio June 1-2, 1999. Abstracts. 21st Finnish NMR Symposium. Kuopio June 2-4, 1999. Abstracts
Vepsäläinen J, 1999, -. C2 Edited book, conference proceedings or special issue of a journal -
Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates
Vepsäläinen JJ, 1999, Tetrahedron letters, 40, 8491-8493, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid
Niemi R, Vepsäläinen J, Taipale H, Järvinen T, 1999, Journal of medicinal chemistry, 42, 24, 5053-5058, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate
Ahlmark M, Vepsäläinen J, Taipale H, Niemi R, Järvinen T, 1999, Journal of medicinal chemistry, 42, 8, 1473-1476, . A1 Journal article (refereed), original research -
Characterization of a conformationally flexible system: NMR spectroscopic study of 1,5-diphenylpentane-2,4-dione
Pulkkinen JT, Laatikainen R, Vepsäläinen JJ, Ahlgrén MJ, 1999, Magnetic resonance in chemistry, 37, 119-126, . A1 Journal article (refereed), original research -
Novel methylenebisphosphonic acid derivatives
Pohjola E, Vepsäläinen J, Nupponen H, Kähkönen J, Laurén L, Hannuniemi R, Järvinen T, Ahlmark M, 1999, . H1 Granted patent -
Nuclear magnetic resonance and molecular orbital study of some cocaine analogues
Airaksinen AJ, Tuppurainen KA, Lötjönen SE, Niemitz M, Yu M, Vepsäläinen JJ, Laatikainen R, Hiltunen J, Bergström KA, 1999, Tetrahedron, 55, 10537-10546, . A1 Journal article (refereed), original research -
Radiolääkekehitys avaa uusia ikkunoita aivoihin
Bergström K, Airaksinen A, Lötjönen S, Kuikka J, Vepsäläinen J, 1999, Kemia, 26, 5, 391-394, . D1 Article in a trade journal -
Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid as novel naproxen prodrugs for dermal drug delivery
Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T, 1999, Pharmaceutical research, 16, 8, 1172-1178, . A1 Journal article (refereed), original research -
Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel partial amides of clodronic acid
Niemi R, Pennanen H, Vepsäläinen J, Taipale H, Järvinen T, 1998, International journal of pharmaceutics, 174, 111-115, . A1 Journal article (refereed), original research -
In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen
Rautio J, Taipale H, Gynther J, Vepsäläinen J, Nevalainen T, Järvinen T, 1998, Journal of pharmaceutical sciences, 87, 12, 1622-1628, . A1 Journal article (refereed), original research -
Complete spectral analysis of the 1H NMR 16-spin system of beta-pinene
Kolehmainen E, Laihia K, Laatikainen R, Vepsäläinen J, Niemitz M, Suontamo R, 1997, Magnetic resonance in chemistry, 35, 463-467, . A1 Journal article (refereed), original research -
Identification of a common structural motif in the disordered N-terminal region of bacterial flagellins Evidence for a new class of fibril-forming peptides
Hakalehto E, Santa H, Vepsäläinen J, Laatikainen R, Finne J, 1997, Febs journal, 250, 19-29, . A1 Journal article (refereed), original research -
Preparation and identification of tetraamide esters of methylene- and (dichloromethylene)bisphosphonates
Vepsäläinen J, Vainiotalo P, Nupponen H, Pohjola E, 1997, ACTA CHEMICA SCANDINAVICA, 51, 932-937, . A1 Journal article (refereed), original research -
Simultaneous determination of clodronate and its partial ester derivatives by ion-pair reversed-phase high-performance liquid chromatography coupled with evaporative light-scattering detection
Niemi R, Taipale H, Ahlmark M, Vepsäläinen J, Järvinen T, 1997, Journal of chromatography b: analytical technologies in the biomedical and life sciences, 701, 97-102, . A1 Journal article (refereed), original research -
Strategies for the selective synthesis of monosubstituted (dichloromethylene)bisphosphonate esters
Ahlmark MJ, Vepsäläinen JJ, 1997, Tetrahedron, 53, 47, 16153-16160, . A1 Journal article (refereed), original research -
3-unsubstituted 1,5-Diaryl-2,4-pentanediones and -4-methoxy-2- pentanones: Synthesis via corresponding 3-hydroxy ketones generated from 2-isoxazolines
Pulkkinen JT, Vepsäläinen JJ, 1996, Journal of organic chemistry, 61, 8604-8609, . A1 Journal article (refereed), original research -
Bisphosphonic compounds VIII. A facile and selective one-pot synthesis of P,P-dialkyl (dichloromethylene)bisphosphonate partial esters
Vepsäläinen J, Nupponen H, Pohjola E, 1996, Tetrahedron letters, 37, 20, 3533-3536, . A1 Journal article (refereed), original research -
General strategies for total-lineshape-type spectral analysis of NMR spectra using integral-transform iterator
Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T, Vepsäläinen J, 1996, JOURNAL OF MAGNETIC RESONANCE (A), 120, 1-10, . A1 Journal article (refereed), original research -
New aminooxy analogs of biogenic polyamines (in Russian)
Khomutov AR, Shvetsov AS, Vepsalainen J, Kramer DL, Hyvonen T, Keinanen T, Eloranta TO, Porter CW, Khomutov RM, 1996, Bioorganicheskaya khimiya, 22, 7, 557-559, . A1 Journal article (refereed), original research -
Performic acid oxidation of exo-2-syn-7-bicyclo[2.2.1]hept-5-enediol. 1H and 13C NMR spectroscopic structure elucidation of the reaction products
Laihia K, Kolehmainen E, Mänttäri P, Ryynänen R, Messala-Rannanpiha M, Vepsäläinen J, Sundelin J-P, 1996, Spectrochimica acta part a: molecular and biomolecular spectroscopy, 51, 495-504, . A1 Journal article (refereed), original research -
Preparation and structure determination of 1-benzyl-, 1-methyl- and 1H-5-[(nitro-2-phenyl)ethenyl]imidazoles
Aulaskari P, Ahlgrén M, Rouvinen J, Vainiotalo P, Pohjala E, Vepsäläinen J, 1996, Journal of heterocyclic chemistry, 33, 1345-1354, . A1 Journal article (refereed), original research -
Synthesis of hydroxylamine analogues of polyamines
Khomutov AR, Vepsäläinen JJ, Shvetsov AS, Hyvönen T, Keinänen TA, Pustobaev VN, Eloranta TO, Khomutov RM, 1996, Tetrahedron, 52, 43, 13751-13766, . A1 Journal article (refereed), original research -
An improved synthetic method and the first crystal structures for (dihalomethylene)bisphosphonate partial esters
Vepsäläinen JJ, Kivikoski J, Ahlgrén M, Nupponen HE, Pohjola EK, 1995, Tetrahedron, 51, 24, 6805-6818, . A1 Journal article (refereed), original research -
Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions
Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A, 1995, Journal of pharmaceutical sciences, 84, 5, 656-660, . A1 Journal article (refereed), original research -
Conformationally biased tri- and di-basic 1,3,5-triazacyclohexyl ligands
Angelis de S, Batsanov A, Norman TJ, Parker D, Senanayake K, Vepsalainen J, 1995, Chemical communications, 2361-2363, . A1 Journal article (refereed), original research -
Synthesis of a tritium labelled antihistaminic drug [3H]-N,N-diethyl-2-[4-(phenylmethylphenoxy]-ethaneamine * HCl
Kovalainen JT, Morimoto H, Williams PG, Vepsäläinen J, Reijonen A, Gynther J, 1995, Journal of labelled compounds and radiopharmaceuticals, 36, 12, 1147-1156, . A1 Journal article (refereed), original research -
A general route to 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones
Pulkkinen, Juha; Vepsäläinen, Jouko; Laatikainen, Reino, 1994, Tetrahedron letters, 35, 52, 9749-9750, . A1 Journal article (refereed), original research