Jouko Vepsäläinen

A study protocol for chemical analysis and toxicity testing of virgin and recycled microplastics and associated chemicals

Järvelä, Essi; Peräniemi, Sirpa; Vepsäläinen, Jouko; Hrovat, Blaž; Raninen, Kaisa; Tomppo, Laura; Koistinen, Arto; Rysä, Jaana, 2025, Science of the total environment, 975, 179287. A1 Journal article (refereed), original research

Advancements and feasibility of synergistic approaches in phosphorus recovery from wastewater: A critical review

Kaur, Parminder; Szlachta, Małgorzata; Xu, Junhua; Vepsäläinen, Jouko; Lappalainen, Reijo; Hussin, Farihahusnah; Aroua, Mohamed Kheireddine, 2025, Journal of environmental management, 386, 125786. A2 Review article, Literature review, Systematic review

Bisphosphonate functionalized biogenic nanostructured silicon carbide for uranium and scandium recovery

Iftekhar, Sidra; Haluska, Ondřej; Rahmani, Arezoo; Thapa, Rinez; Riikonen, Joakim; Lappalainen, Reijo; Vepsäläinen, Jouko; Lehto, Vesa-Pekka, 2025, Chemosphere, 379, 144404. A1 Journal article (refereed), original research

Urinary levels of oestradiol and pregnanediol glucuronides reflect the ovarian function in the domestic dog (Canis familiaris)

Pennanen, Tia M; Lindeberg, Heli; Mononen, Jaakko; Vepsäläinen, Jouko; Hujo, Mika; Viitala, Sari, 2025, Animal reproduction science, 281, 107973. A1 Journal article (refereed), original research

17O NMR spectroscopy protocol for the determination of water content in liquids produced by pyrolysis and hydrothermal liquefaction

Jokinen, Noora; Eronen, Eemeli; Vepsäläinen, Jouko; Jänis, Janne; Lappalainen, Reijo; Tomppo, Laura; Tynkkynen, Tuulia, 2024, Analytica chimica acta, 1329, 343188. A1 Journal article (refereed), original research

Catalytic action of hydronium-ion in rice straw pretreatment and enhancement of enzymatic hydrolysis and ethanol production

Manna, Dinabandhu; Chowdhury, Ranjana; Hassan, Md. Kamrul; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari, 2024, Next energy, 3, 100112. A1 Journal article (refereed), original research

Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses

Rajamäki, Anni; Lehtovirta, Lari; Niemeläinen, Mika; Reito, Aleksi; Parkkinen, Jyrki; Peräniemi, Sirpa; Vepsäläinen, Jouko; Eskelinen, Antti, 2024, Bone joint research, 13, 4, 149-156. A1 Journal article (refereed), original research

Scent Detection Threshold of Trained Dogs to Eucalyptus Hydrolat

Turunen, Soile; Paavilainen, Susanna; Vepsäläinen, Jouko; Hielm-Björkman, Anna, 2024, Animals, 14, 7, 1083. A1 Journal article (refereed), original research

Farmaseuttinen kemia

Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo, 2023, Publications of the University of Eastern Finland : general series, 44, 32-35. E1 Popularised article, newspaper article

Mikromuovien analytiikan ja poistomenetelmien kehittäminen teollisuuden laadunvalvontaan

Raninen, Kaisa; Uurasjärvi, Emilia; Peräniemi, Sirpa; Soininen, Tuomo; Vepsäläinen, Jouko; Järvelä, Essi; Riekkinen, Kati; Karim, Shahina; Selenius, Mikko; Savolainen, Ritva; Visuri, Roosa; Koistinen, Arto; Tomppo, Laura, 2023, Itä-Suomen yliopisto. D4 Published development or research report or study

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia, 2023, Metabolites, 13, 2, 233. A2 Review article, Literature review, Systematic review

Syljen metabolomiikan sovellutuksia suulääketieteellisessä tutkimuksessa

Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia, 2023, Suomen hammaslääkärilehti, 30, 10, 27. D1 Article in a trade journal

Valorization potential of the aqueous products from hydrothermal liquefaction and stepwise slow pyrolysis of wood bark and hemp hurds with yields and product comparison

Jokinen, Noora; Eronen, Eemeli; Salami, Ayobami; Hyttinen, Marko; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo; Tomppo, Laura, 2023, Bioresource technology reports, 21, 101385. A1 Journal article (refereed), original research

Effects of tree harvesting time and tannin cold/hot-water extraction procedures on the performance of spruce tannin biocoagulant for water treatment

Bello, Adedayo; Bergmann, Ulrich; Vepsäläinen, Jouko; Leiviskä, Tiina, 2022, Chemical engineering journal, 449, 137809. A1 Journal article (refereed), original research

Functionalized nanoporous silicon for extraction of Sc from a leach solution

Rahmani, Arezoo; Thapa, Rinez; Aalto, Juha Matti; Turhanen, Petri; Vepsäläinen, Jouko; Lehto, Vesa Pekka; Riikonen, Joakim, 2022, Hydrometallurgy, 211, 105866. A1 Journal article (refereed), original research

Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X-ray Fluorescence (pXRF) System

Tiihonen, Tommi E; Nissinen, Tuomo J; Turhanen, Petri A; Vepsäläinen, Jouko J; Riikonen, Joakim; Lehto, Vesa Pekka, 2022, Analytical chemistry, 94, 34, 11739-11744. A1 Journal article (refereed), original research

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R., 2022, International journal of molecular sciences, 23, 9, 4614. A1 Journal article (refereed), original research

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A, 2021, Biomolecules, 11, 5, 707. A1 Journal article (refereed), original research

A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots

Salami, Ayobami; Heikkinen, Jorma; Tomppo, Laura; Hyttinen, Marko; Kekäläinen, Timo; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo, 2021, Molecules, 26, 11, 3167. A1 Journal article (refereed), original research

Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture

Kuittinen, Suvi; Hietaharju, Jenna; Kupiainen, Laura; Hassan, Md. Kamrul; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Kangas, Jani; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari, 2021, Journal of cleaner production, 293, 126088. A1 Journal article (refereed), original research

Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria

Virpiranta, Hanna; Taskila, Sanna; Leiviskä, Tiina; Vepsäläinen, Jouko; Rämö, Jaakko; Tanskanen, Juha, 2021, Journal of water and climate change, 12, 8, 3544-3557. A1 Journal article (refereed), original research

Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel

Nissinen, Samuli I; Venäläinen, Markus; Kumpulainen, Pekka; Roine, Antti; Häkkinen, Merja R; Vepsäläinen, Jouko; Oksala, Niku; Rantanen, Tuomo, 2021, Cancer control, 29, 1-9. A1 Journal article (refereed), original research

Effect of solvent mixture pretreatment on sugar release from short-rotation coppice Salix schwerinii for biobutanol production

Yang, Ming; Guo, Xiaojun; Liu, Guozhen; Nan, Yufei; Zhang, Junhua; Noyazzesh, Hossain; Kuittinen, Suvi; Vepsäläinen, Jouko; Pappinen, Ari, 2021, Bioresource technology, 344, Part B, 126262. A1 Journal article (refereed), original research

Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus

Lehtiniemi, Maiju; Hartikainen, Samuel; Turja, Raisa; Lehtonen, Kari K.; Vepsäläinen, Jouko; Peräniemi, Sirpa; Leskinen, Jari; Setälä, Outi, 2021, Marine pollution bulletin, 173, Part B, 113103. A1 Journal article (refereed), original research

Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds

Verkasalo, Erkki; Möttönen, Veikko; Roitto, Marja; Vepsäläinen, Jouko; Kumar, Anuj; Ilvesniemi, Hannu; Siwale, Workson; Julkunen-Tiitto, Riitta; Raatikainen, Olavi; Sikanen, Lauri, 2021, Forests, 12, 2, 192. A1 Journal article (refereed), original research

Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption

Haluska, Ondrej; Rahmani, Arezoo; Salami, Ayobami; Turhanen, Petri; Vepsäläinen, Jouko; Lappalainen, Reijo; Lehto, Vesa-Pekka; Riikonen, Joakim, 2021, Microporous and mesoporous materials, 324, 111294. A1 Journal article (refereed), original research

Recovery of uranium with bisphosphonate modified mesoporous silicon

Thapa, Rinez; Rahmani, Arezoo; Turhanen, Petri; Taskinen, Antti; Nissinen, Tuomo; Neitola, Raisa; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim, 2021, Separation and purification technology, 272, 118913. A1 Journal article (refereed), original research

Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms

Hagner, Marleena; Räty, Mari; Nikama, Johanna; Rasa, Kimmo; Peltonen, Sari; Vepsäläinen, Jouko; Keskinen, Riikka, 2021, Science of the total environment, 784, 147139. A1 Journal article (refereed), original research

Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams

Sandar, Sandra; Yang, Ming; Turunen, Ossi; Vepsäläinen, Jouko; Pappinen, Ari; Kuittinen, Suvi, 2020, Bioresources, 15, 4, 9265-9290. A1 Journal article (refereed), original research

Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing

Salami, Ayobami; Raninen, Kaisa; Heikkinen, Jorma; Tomppo, Laura; Vilppo, Teemu; Selenius, Mikko; Raatikainen, Olavi; Lappalainen, Reijo; Vepsäläinen, Jouko, 2020, Industrial crops and products, 155, 112760. A1 Journal article (refereed), original research

Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process

Salami, A; Vilppo, T; Pitkänen, S; Weisell, J; Raninen, K; Vepsäläinen, J; Lappalainen, R, 2020, Scientific African, 8, 1-13. A1 Journal article (refereed), original research

Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent

Szlachta, Malgorzata; Neitola, Raisa; Peräniemi, Sirpa; Vepsäläinen, Jouko, 2020, Separation and purification technology, 253, 117493. A1 Journal article (refereed), original research

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsäläinen, Jouko; Khomutov, Alex, 2020, Communications chemistry, 3, 1, 121. A1 Journal article (refereed), original research

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex, 2020, Biomolecules, 10, 3, 406. A1 Journal article (refereed), original research

Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum

Hagner, Marleena; Lindqvist, Bengt; Vepsäläinen, Jouko; Samorì, Chiara; Keskinen, Riikka; Rasa, Kimmo; Hyvönen, Terho, 2020, Environmental technology and innovation, 20, 101154. A1 Journal article (refereed), original research

Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils

Mohsin, Muhammad; Kuittinen, Suvi; Abdus Salam, Mir Md; Peräniemi, Sirpa; Laine, Saila; Pulkkinen, Pertti; Kaipiainen, Erik; Vepsäläinen, Jouko; Pappinen, Ari, 2019, Journal of geochemical exploration, 205, 106335. A1 Journal article (refereed), original research

Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation

Yang, Ming; Wang, Jia; Nan, Yufei; Zhang, Junhua; Li, Liyun; Liu, Guozhen; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari, 2019, Rsc advances, 9, 58, 33755-33760. A1 Journal article (refereed), original research

Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach

Turhanen, Petri; Leppänen, Jukka; Vepsäläinen, Jouko J, 2019, ACS omega, 4, 5, 8974-8984. A1 Journal article (refereed), original research

Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti

Turunen, Kaisa; Antikainen, Eero; Huotari-Halkosaari, Taija; Ikonen, Jenni; Janhunen, Maarit; Lahtinen, Tatu; Lerssi, Jouni; Miettinen, Ilkka; Meriläinen, Päivi; Niittynen, Marjo; Pullinen, Arto; Reijonen, Tero; Raatikainen, Mika; Sonninen, Jari; Torvinen, Olli; Vauhkonen, Marko; Vepsäläinen, Jouko, 2019. D4 Published development or research report or study

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M, 2019, International journal of epidemiology, 48, 3, 978-993. A1 Journal article (refereed), original research

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R, 2019, Journal of medicinal chemistry, 62, 24, 11335-11347. A1 Journal article (refereed), original research

Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf

Kuittinen, Suvi; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari, 2018, Bioresources, 13, 3, 5225-5240. A1 Journal article (refereed), original research

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase

Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R, 2018, Mendeleev communications, 28, 5, 479-481. A1 Journal article (refereed), original research

Altered polyamine profiles in colorectal cancer

Venäläinen, Markus K; Roine, Antti N; Häkkinen, Merja R; Vepsäläinen, Jouko J; Kumpulainen, Pekka S; Kiviniemi, Mikko S; Lehtimäki, Terho; Oksala, Niku K; Rantanen, Tuomo K, 2018, Anticancer research, 38, 6, 3601-3607. A1 Journal article (refereed), original research

Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement

Lehtovirta, L; Reito, A; Parkkinen, J; Peräniemi, S; Vepsäläinen, J; Eskelinen, A, 2018, PLoS ONE, 13, 5, e0197614. A1 Journal article (refereed), original research

Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration

Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T, 2018, Biochemical journal, 475, 3, 663-676. A1 Journal article (refereed), original research

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko, 2018, Bioscience reports, 38, 4, BSR20180527. A1 Journal article (refereed), original research

Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production

Yang, Ming; Xu, Minyuan; Nan, Yufei; Kuittinen, Suvi; Hassan, Md Kamrul; Vepsäläinen, Jouko; Xin, Donglin; Zhang, Junhua; Pappinen, Ari, 2018, Bioresource technology, 257, 113-120. A1 Journal article (refereed), original research

Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement

Yang Ming, Kuittinen Suvi, Vepsäläinen Jouko, Zhang Junhua, Pappinen Ari, 2017, Bioresource technology, 243, 126-134. A1 Journal article (refereed), original research

On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge

Khomich OA, Yanvarev DV, Novikov RA, Kornev AB, Puljulla E, Vepsäläinen J, Khomutov AR, Kochetkov SN, 2017, Molecules, 22, 7, e1040. A1 Journal article (refereed), original research

Urinary Polyamines as Biomarkers for Ovarian Cancer

Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U, 2017, International journal of gynecological cancer, 27, 7, 1360-1366. A1 Journal article (refereed), original research

Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids

Khomutov MA, Formanovsky AA, Mikhura IV, Vepsäläinen Jouko, Kochetkov SN, De Biase D, Khomutov AR, 2016, Russian journal of bioorganic chemistry, 42, 6, 672-676. A1 Journal article (refereed), original research

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase

Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN, 2016, Data in brief, 8, 1157-1167. A1 Journal article (refereed), original research

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN, 2016, Biochimie, 127, 153-162. A1 Journal article (refereed), original research

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase

Khomutov MA, Simonian AR, Weisell J, Vepsäläinen J, Kochetkov SN, 2016, Russian journal of bioorganic chemistry, 42, 4, 415-422. A1 Journal article (refereed), original research

Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach

Turhanen Petri, Vepsäläinen Jouko, 2016, Rsc advances, 6, 15937-15940. A1 Journal article (refereed), original research

Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

Puljula Elina, Vepsäläinen Jouko, Turhanen Petri, 2016, Beilstein journal of organic chemistry, 12, 2145-2149. A1 Journal article (refereed), original research

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A, 2016, Biochemical journal, 473, 10, 1433-1441. A1 Journal article (refereed), original research

A powerful tool for acid catalyzed organic addition and substitution reactions

Turhanen Petri, Vepsäläinen Jouko, 2015, Rsc advances, 5, 26218-26222. A1 Journal article (refereed), original research

Advanced material and approach for metal ions removal from aqueous solutions

Turhanen Petri A, Vepsäläinen Jouko J, Peräniemi Sirpa, 2015, Scientific reports, 5, 8992. A1 Journal article (refereed), original research

Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid

Laakso Mikko P, Jukarainen Niko M, Vepsäläinen Jouko, 2015, Journal of neurology neurosurgery and psychiatry, 86, 12, 1286-1290. A1 Journal article (refereed), original research

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, 2015, Acs chemical biology, 10, 6, 1417-1424. A1 Journal article (refereed), original research

Enantioselective synthesis of (R)- and (S)-3-methylspermidines

Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR, 2015, Russian journal of bioorganic chemistry, 41, 5, 548-553. A1 Journal article (refereed), original research

Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation

Yang Ming, Zhang Junhua, Kuittinen Suvi, Vepsäläinen Jouko, Soininen Pasi, Keinänen Markku, Pappinen Ari, 2015, Bioresource technology, 189, 131-137. A1 Journal article (refereed), original research

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna, 2015, Chemical research in toxicology, 28, 4, 702-710. A1 Journal article (refereed), original research

Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives

Ucal Sebahat, Khomutov Alex R, Häkkinen Merja R, Turhanen Petri A, Vepsäläinen Jouko J, Weisell Janne, 2015, Arkivoc, 2015, 7, 42-49. A1 Journal article (refereed), original research

Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters

Puljula Elina, Turhanen Petri, Vepsäläinen Jouko, Monteil Maelle, Lecouvey Marc, Weisell Janne, 2015, Acs medicinal chemistry letters, 6, 4, 397-401. A1 Journal article (refereed), original research

Synthesis of biologically active analogues of spermine and spermidine

Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R., 2015, Amino acids.

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Weisell Janne, Vepsäläinen Jouko, Turhanen Petri A, 2015, Beilstein journal of organic chemistry, 11, 2189-2193. A1 Journal article (refereed), original research

Urinary acetylated polyamines in ovarian cancer

Mäenpää Johanna Unelma, Niemi Riikka, Roine Antti, Häkkinen Merja, Kumpulainen Pekka, Keinänen Tuomo, Vepsäläinen Jouko, Lehtimäki Terho, Oksala Niku, 2015, Journal of clinical oncology.

Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence

Castro-Oropeza R, Pino-Ángeles A, Khomutov MA, Urdiales JL, Moya-García AA, Vepsäläinen J, Persson L, Sarabia F, Khomutov A, Sánchez-Jiménez F, 2014, Amino acids, 46, 621-631. A1 Journal article (refereed), original research

Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques

Julkunen-Tiitto Riitta, Nenadis Nikolaos, Neugart Susanne, Robson Matthew, Agati Giovanni, Vepsäläinen Jouko, Zipoli Gaetano, Nybakken Line, Winkler Barbro, Jansen Marcel AK, 2014, Phytochemistry reviews, 2015; 14, 2, 273-297. A2 Review article, Literature review, Systematic review

Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production

Yang Ming, Kuittinen Suvi, Zhang Junhua, Vepsäläinen Jouko, Keinänen Markku, Pappinen Ari, 2014, Bioresource technology, 2015; 179, 128-135. A1 Journal article (refereed), original research

Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study

Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K, 2014, Journal of urology, 192, 230-235. A1 Journal article (refereed), original research

Eletroninen nenä havaitsee eturauhassyövän virtsasta [Detection of prostate cancer by an eletronic nose: a proof-of-principle study. J Urol, julkaistu verkossa 25.2.2014]

Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K, 2014, Duodecim, 130, 53. B1 Non-refereed journal articles

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN, 2014, Biochemistry: moscow, 2013; 78, 13, 1431-1446. A2 Review article, Literature review, Systematic review

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku, 2014, Chemical research in toxicology, 27, 1950-1957. A1 Journal article (refereed), original research

Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J, 2014, Phytochemical analysis, 25, 220-228. A1 Journal article (refereed), original research

Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J, 2014, Food chemistry, 165, 499-505. A1 Journal article (refereed), original research

Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme

Keinanen TA, Hyvonen T, Vepsalainen J, Alhonen L, Khomutov AR, Janne J, 2014, Russian journal of bioorganic chemistry, 40, 155-161. A1 Journal article (refereed), original research

The use of (green field) biomass pretreatment liquor for fermentative butanol production and the catalytic oxidation of biobutanol

Yang Ming, Kuittinen Suvi, Keinänen Markku, Vepsäläinen Jouko, Romar Henrik, Tynjälä Pekka, Lassi Ulla, Pappinen Ari, 2014, Chemical engineering research and design, 92, 8, 1531-1538. A1 Journal article (refereed), original research

Uraanin ja muiden raskasmetallien poistaminen vedestä

Vepsäläinen Jouko, 2014, Ympäristö ja terveys, 45, 2, 72-76. D1 Article in a trade journal

A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens

Alanne Aino-Liisa, Peräniemi Sirpa, Turhanen Petri, Tuomainen Marjo, Vepsäläinen Jouko, Tervahauta Arja, 2013, Chemosphere, 2014:95, 566-571. A1 Journal article (refereed), original research

A novel bisphosphonate-based solid phase method for effective removal of chromium(III) from aqueous solutions and tannery effluents

Alanne Aino-Liisa, Tuikka Matti, Tõnsuaadu Kaia, Ylisirniö Markku, Hämäläinen Lea, Turhanen Petri, Vepsäläinen Jouko, Peräniemi Sirpa, 2013, Rsc advances, 3, 14132-14138. A1 Journal article (refereed), original research

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS

Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko, 2013, Journal of chromatography b: analytical technologies in the biomedical and life sciences, 941, 81-89. A1 Journal article (refereed), original research

Charge deficient analogues of the natural polyamines

Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R, 2013, Current pharmaceutical design, 2014:20, 2, 262-277. A2 Review article, Literature review, Systematic review

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko, 2013, European journal of pharmaceutical sciences, 49, 624-628. A1 Journal article (refereed), original research

First bisphosphonate hydrogelators: potential composers of biocompatible gels

Alanne Aino-Liisa, Lahtinen Manu, Löfman Miika, Turhanen Petri, Kolehmainen Erkki, Vepsäläinen Jouko, Sievänen Elina, 2013, Journal of materials chemistry. b, 1, 6201-6212. A1 Journal article (refereed), original research

Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity

Meinander Kristian, Weisell Janne, Pakkala Miikka, Tadd Andrew C, Hekim Can, Kallionpää Roope, Widell Kim, Stenman Ulf-Håkan, Koistinen Hannu, Närvänen Ale, Vepsäläinen Jouko, Luthman Kristina, Wallén Erik AA, 2013, Medchemcomm, 4, 549-553. A1 Journal article (refereed), original research

Selective regulation of polyamine metabolism with methylated polyamine analogues

Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, 2013, Amino acids, 2014:46, 605-620. A2 Review article, Literature review, Systematic review

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

Agapkina Julia, Yanvarev Dmitry, Anisenko Andrey, Korolev Sergey, Vepsäläinen Jouko, Kochetkov Sergey, Gottikh Marina, 2013, European journal of medicinal chemistry, 2014:73, 73-82. A1 Journal article (refereed), original research

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A, 2013, Biochemical journal, 453, 467-474. A1 Journal article (refereed), original research

Tautomeric populations of the charged species of 1,12-diamino-3,6,9-triazadodecane (SpmTrien) studied with computer simulations and cluster expansions

Weisell Janne, Vepsäläinen Jouko, Peräkylä Mikael, 2013, Journal of physical organic chemistry, 26, 360-366. A1 Journal article (refereed), original research

The selective stepwise chemical hydrolysis of alkylcarbonate groups from novel mixed alkylcarbonate trialkyl ester derivatives of etidronic acid

Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J, 2013, Rsc advances, 3, 2417-2421. A1 Journal article (refereed), original research

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells

Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V, 2012, Biochimie, 94, 9, 1876-1883. A1 Journal article (refereed), original research

Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose

Roine Antti, Tolvanen Mikko, Sipiläinen Miki, Kumpulainen Pekka, Helenius Merja A, Lehtimäki Terho, Vepsäläinen Jouko, Keinänen Tuomo A, Häkkinen Merja R, Koskimäki Juha, Veskimäe Erik, Tuokko Antti, Visakorpi Tapio, Tammela Teuvo L, Sioris Thanos, Paavonen Timo, Lekkala Jukka, Helle Hannu, Oksala Niku K, 2012, Future oncology, 8, 9, 1157-1165. A1 Journal article (refereed), original research

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A

Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H, 2012, Amino acids, 42, 685-695. A1 Journal article (refereed), original research

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko, 2012, Journal of pharmaceutical sciences, 101, 8, 2854-2860. A1 Journal article (refereed), original research

Metabolism of bilirubin by human cytochrome P450 2A6

Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A, 2012, Toxicology and applied pharmacology, 261, 50-58. A1 Journal article (refereed), original research

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase

Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, 2012, Drug metabolism and disposition, 2013:41, 30-32. A1 Journal article (refereed), original research

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS

Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A, 2012, Amino acids, 42, 451-460. A1 Journal article (refereed), original research

Preparation of mixed trialkyl alkylcarbonate derivates of etidronic acid via an unusual route

Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J, 2012, Beilstein journal of organic chemistry, 8, 2019-2024. A1 Journal article (refereed), original research

Synthesis of novel bisphosphonate polyamine conjugates and their affinity to hydroxyapatite

Sankala Elina, Weisell Janne M, Huhtala Tuulia, Närvänen Ale T.O, Vepsäläinen Jouko J, 2012, Arkivoc, 2012, 4, 233-241. A1 Journal article (refereed), original research

Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates

Alanne Aino-Liisa, Hyvönen Helena, Lahtinen Manu, Ylisirniö Markku, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko, 2012, Molecules, 17, 9, 10928-10945. A1 Journal article (refereed), original research

The combined use of constrained total-line-shape 1H NMR and LC-MS/MS for quantitative analysis of bioactive components in yellow onion

Soininen Tuula H, Jukarainen Niko, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J, 2012, Journal of food composition and analysis, 25, 208-214. A1 Journal article (refereed), original research

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase

Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena, 2012, Amino acids, 42, 485-493. A1 Journal article (refereed), original research

A novel strategy for the synthesis of enzymatically stable biotin-DOTA conjugates for in vivo use

Turhanen Petri A, Weisell Janne, Lehtolainen-Dalkilic Pauliina, Määttä Ann-Marie, Vepsäläinen Jouko, Närvänen Ale, 2011, Medchemcomm, 2, 2, 886-888. A1 Journal article (refereed), original research

Complex N-Acetylation of Triethylentetramine

Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen, 2011, Drug metabolism and disposition, 39, 12, 2242-2249. A1 Journal article (refereed), original research

Novel metabolically stable functionally active mimetic of spermidine

Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA, 2011, Russian journal of bioorganic chemistry, 37, 2, 253-258. A1 Journal article (refereed), original research

The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism

Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov, 2011, Journal of medicinal chemistry, 54, 13, 4611-4618. A1 Journal article (refereed), original research

A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids

Komissarov VV, Kritzyn AM & Vepsäläinen J, 2010, Beilstein journal of organic chemistry, 6, 63, 1-5. A1 Journal article (refereed), original research

Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L, 2010, Pancreatology, 10, 208-221. A1 Journal article (refereed), original research

Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products

Kunnas-Hiltunen S, Haukka M, Vepsäläinen JJ & Ahlgrén M, 2010, Dalton transactions, 39, 5310-5318. A1 Journal article (refereed), original research

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage

Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ, 2010, Biomacromolecules, 11, 97-105. A1 Journal article (refereed), original research

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases

Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T, 2010, Amino acids, 38, 369-381. A1 Journal article (refereed), original research

Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3 stimulating peptide B-2.

Pakkala M, Weisell J, Hekim C, Vepsäläinen J, Wallen E, Stenman U-H, Koistinen H, Närvänen A., 2010, Amino acids, 39, 1, 233-236. A1 Journal article (refereed), original research

Novel convenient synthesis of biologically active esters of hydroxylamine

Maxim A. Khomutov, Swati Mandal, Janne Weisell, Neiha Saxena, Alina R. Simonian, Jouko Vepsalainen, Rentala Madhubala, Sergey N. Kochetkov, 2010, Amino acids, 38, 509-517. A1 Journal article (refereed), original research

Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity

Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P, 2010, Amino acids, 38, 2, 501-507. A1 Journal article (refereed), original research

Organic-Inorganic Hybrid Materials: Synthesis, X-ray Diffraction Study and Characterisations of Manganese, Coboalt and Copper Complexes of Modified Bis(phosphonates)

Kunnas-Hiltunen S, Laurila E, Haukka M, Vepsäläinen JJ & Ahlgrén M, 2010, Zeitschrift fur anorganische und allgemeine chemie, 636, 710-720. A1 Journal article (refereed), original research

Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al, 2010, Journal of medicinal chemistry, 53, 15, 5738-5748. A1 Journal article (refereed), original research

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage

Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L, 2010, Amino acids, 38, 575-581. A1 Journal article (refereed), original research

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography

Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P, 2009, Journal of pharmaceutical and biomedical analysis, 50, 469-474. A1 Journal article (refereed), original research

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA, 2009, Biochemical journal, 422, 321-328. A1 Journal article (refereed), original research

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J, 2009, MOLEKULIARNAIA BIOLOGIIA [MOSKVA], 43, 2, 274-285. A1 Journal article (refereed), original research

Poly[(acetone)tetraaqua[my6-ethyl(dichloromethylene)diphosphonato]-[my5-ethyl (dichloromethylene)-diphosphonato]tribarium(II)]

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section C : crystal structure communications, C65, m165-m167. A1 Journal article (refereed), original research

Poly[[my-aqua-aqua[myy4-ethyl(dichloromethylene)diphosphonato]sesquicalcium(II)] acetone hemisolvate 4.5-hydrate]

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section E : structure reports online, E65, m436-m437. A1 Journal article (refereed), original research

Syntheses, X-ray diffraction study and characterisations of Ni an Zn complexes of clodronic acid and its dibenzoyl derivate

Kunnas-Hiltunen S, Haukka M, Vepsäläinen J, Ahlgrén M, 2009, European journal of inorganic chemistry, 5335-5345. A1 Journal article (refereed), original research

Synthesis of novel deuterium labelled derivates of N-alkylated polyamines

Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J, 2009, Tetrahedron, 65, 2, 547-562. A1 Journal article (refereed), original research

Synthesis of phenyl substituted bisphosphonates and crystal structures and characterization of Cd complexes of (dichloromethylene)bisphosphonic acid phenyl and alkyl ester derivatives

Jokiniemi J, Vepsäläinen J, Nätkinniemi H, Peräniemi S, Ahlgrén M, 2009, Crystengcomm, 11, 2431-2440. A1 Journal article (refereed), original research

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J, 2009, Journal of medicinal chemistry, 52, 4142-4148. A1 Journal article (refereed), original research

X-ray diffraction study of bisphosphonate metal complexes: Mg, Sr and Ba complexes of (dichloromethylene)bisphosphonic acid P,P'-dibenzoyl anhydride

Kunnas-Hiltunen S, Matilainen M, Vepsäläinen JJ, Ahlgrén M, 2009, Polyhedron, 28, 200-204. A1 Journal article (refereed), original research

catena-Poly[[diaquacadmium(II)]-mu-(methyl morpholino dicholromethylene-disphosphonato)-kappa3O,O':O''-[tetraaqua-cadmium(II)-mu-(methyl morpholino dichloromethylenediphosphonato)-kappa3O:O',O'']

Jokiniemi J, Vepsäläinen J, Ahlgrén M, 2009, Acta crystallographica section E : structure reports online, E65, M600-M601. A1 Journal article (refereed), original research

A structural study of alkaline earth metal complexes of (dicholoromethylene)bisphosphonic acid P-morpholinium- and P-pyrrolidinium-P'-methyl esters

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M, 2008, Crystengcomm, 10, 1011-1017. A1 Journal article (refereed), original research

Ex vivo evaluation of N(3-[18F]fluoroproponyl9-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane in rats

Koivula T, Marjamäki P, Haaparanta M, Fagerholm V, Grönroos T, Lipponen T, Perhola O, Vepsäläinen J, Solin O, 2008, Nuclear medicine and biology, 35, 177-183. A1 Journal article (refereed), original research

Novel agmatine analogue, gamma-quanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels

Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R, 2008, Biochemical and biophysical research communications, 375, 168-172. A1 Journal article (refereed), original research

Quantification of 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis

Jukarainen NM, Korhonen S-P, Laakso MP, Korolainen MA, Niemitz M, Soininen PP, Tuppurainen K, Vepsäläinen J, Pirttilä T, Laatikainen R, Pirttilä T, 2008, Metabolomics, 4, 150-160. A1 Journal article (refereed), original research

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S, 2008, Journal of pharmaceutical and biomedical analysis, 48, 414-421. A1 Journal article (refereed), original research

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J, 2008, European journal of pharmaceutical sciences, 34, 110-117. A1 Journal article (refereed), original research

Towards metformin prodrugs

Huttunen KM, Leppänen J, Kemppainen E, Palonen P, Rautio J, Järvinen T, Vepsäläinen J, 2008, Synthesis: stuttgart, 22, 3619-3624. A1 Journal article (refereed), original research

Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions

Turhanen PA, Vepsäläinen JJ, 2008, Beilstein journal of organic chemistry, 4, 7. A1 Journal article (refereed), original research

2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JAM, Forsberg MM, Männistö PT, Wallén EAA, 2007, Bioorganic and medicinal chemistry, 15, 2024-2031. A1 Journal article (refereed), original research

A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterfied derivatives

Turhanen PA, Demadis KD, Peräniemi S, Vepsäläinen JJ, 2007, Journal of organic chemistry, 72, 4, 1468-1471. A1 Journal article (refereed), original research

Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors

Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman U-H, Vepsäläinen J, Närväinen A, 2007, Journal of peptide science, 13, 348-353. A1 Journal article (refereed), original research

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J, 2007, Mini-reviews in medicinal chemistry, 7, 8, 813-820. A1 Journal article (refereed), original research

Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S, 2007, Journal of pharmaceutical and biomedical analysis, 45, 625-634. A1 Journal article (refereed), original research

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J, 2007, Nucleosides nucleotides and nucleic acids, 26, 1245-1248. A1 Journal article (refereed), original research

Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality

Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J, 2007, Pharmaceutical research, 24, 4, 679-687. A1 Journal article (refereed), original research

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L, 2007, Amino acids, 33, 2, 323-330. A1 Journal article (refereed), original research

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, 2007, Journal of biological chemistry, 282, 48, 34700-34706. A1 Journal article (refereed), original research

Structural study of metal complexes of bisphosphonate amide ester: copper, magnesium, zinc and cadmium complexes of (dichloromethylene)bisphosphonic acid P-piperidinium-P¿-methyl ester

Jokiniemi J, Vuokila-Laine E, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2007, Crystengcomm, 9, 158-164. A1 Journal article (refereed), original research

Synthesis of novel optical isomers of [alpha]-methylpolyamines

Grigorenko NA, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J, 2007, Tetrahedron, 63, 2257-2262. A1 Journal article (refereed), original research

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates

Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J, 2006, British journal of pharmacology, 147, 437-445. A1 Journal article (refereed), original research

A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts

Holappa J, Nevalainen T, Safin R, Vepsäläinen J, Järvinen T, 2006, Tetrahedron letters, 47, 323-325. A1 Journal article (refereed), original research

Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality

Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L, 2006, American journal of pathology, 168, 115-122. A1 Journal article (refereed), original research

Alfa-methyl polyamines: efficient synthesis and tolerance studies in vivo and vitro. First evidence for dormant stereospecificity of polyamine oxidase

Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE, 2006, Journal of medicinal chemistry, 49, 399-406. A1 Journal article (refereed), original research

Aminooxy analogues of spermine and their monoacetyl derivatives

Simonyan AR, Vepsalainen J, Khomutov AR, 2006, Russian journal of bioorganic chemistry, 32, 6, 578-585. A1 Journal article (refereed), original research

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

Jarho EM, Venäläinen J, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JAM, Forsberg MM, Järvinen T, Männistö PT, Wallén EAA, 2006, Bioorganic and medicinal chemistry letters, 16, 5590-5593. A1 Journal article (refereed), original research

Controlling the regio- and stereospecifity of enzyme catalysis with guide molecules

Keinänen T, Järvinen A, Vepsäläinen J, Uimari A, Alhonen L, Jänne J, 2006. H1 Granted patent

Convenient microwave-assisted synthesis of 1-chloroethyl phosphates

Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J, 2006, CHEMINFORM, 37, 26. A1 Journal article (refereed), original research

Efficient strategy to prepare water-soluble prodrugs of ketones

Huttunen KM, Kumpulainen H, Leppänen J, Rautio J, Järvinen T, Vepsäläinen J, 2006, Synlett, 5, 701-704. A1 Journal article (refereed), original research

Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure

Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J, 2006, Journal of medicinal chemistry, 49, 1207-1211. A1 Journal article (refereed), original research

Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase

Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J, 2006, Journal of biological chemistry, 281, 8, 4589-4595. A1 Journal article (refereed), original research

Novel one-pot synthesis of amide derivatives of methylenebisphosphonate utilizing the mesyl moiety as leaving group

Jokiniemi J, Ahlgrén M, Vepsäläinen JJ, 2006, Letters in organic chemistry, 3, 12, 898-900. A1 Journal article (refereed), original research

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T, 2006, Journal of medicinal chemistry, 49, 2022-2027. A1 Journal article (refereed), original research

Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists

Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J, 2006, Chemical biology and drug design, 68, 6, 334-340. A1 Journal article (refereed), original research

Synthesis of novel (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives

Turhanen P, Vepsalainen JJ, 2006, Beilstein journal of organic chemistry, 2:2. A1 Journal article (refereed), original research

The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms

Lewandowicz AM, Vepsäläinen J, Laitinen JT, 2006, British journal of pharmacology, 147, 422-429. A1 Journal article (refereed), original research

A charge-deficient analogue of spermine with chelating properties

Khomutov AR, Grigorenko NA, Skuridin SG, Demin AV, Vepsalainen J, Casero RA, Woster PM, 2005, Russian journal of bioorganic chemistry, 31, 3, 271-278. A1 Journal article (refereed), original research

An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates

Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J, 2005, Journal of organic chemistry, 70, 9056-9058. A1 Journal article (refereed), original research

Catena-Poly[diaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O,O':O''-tetraaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O:O',O'']

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section C : crystal structure communications, E61, m635-m637. A1 Journal article (refereed), original research

Catena-poly[diaquacadmium(II)-my-(diethyl dichloromethylenebisphosphonato)-kappa3 O,O':O'' -tetraaquacadmium(II)-my -(diethyl dichloromethylenebisphosphonato-)kappa3 O:O',O'']

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section C : crystal structure communications, E61, m638-m640. A1 Journal article (refereed), original research

Catena-poly[diaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o,ó:o" -tetraaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o:ó,o"]

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Acta crystallographica section E : structure reports online, E61, m635-m637. A1 Journal article (refereed), original research

Isolation and characterization of yuremamine, a new phytoindole

Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC, 2005, Planta medica, 71, 1053-1057. A1 Journal article (refereed), original research

Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines

Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J, 2005, Journal of biological chemistry, 280, 8, 6595-6601. A1 Journal article (refereed), original research

New charge-deficient agmatine analogues

Simonyan AR, Grigorenko NA, Vepsalainen J, Khomutov AR, 2005, Russian journal of bioorganic chemistry, 31, 6, 583-587. A1 Journal article (refereed), original research

New oxaanalogues of spermine

Khomutov AR, Simonyan AR, Vepsalainen J, Keinanen TA, Alhonen L, Janne J, 2005, Russian journal of bioorganic chemistry, 31, 2, 189-195. A1 Journal article (refereed), original research

New syntheses of alfa-methyl- and alfa,alfa'-dimethylspermine

Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR, 2005, Russian journal of bioorganic chemistry, 31, 2, 183-188. A1 Journal article (refereed), original research

Polymethylene derivatives of nucleic bases with omega-functional groups: IV.1[7-(2-oxocyclohexyl)-7-oxoheptyl]purines

Kritzyn AM, Vepsalainen J, Komissarov VV, 2005, Russian journal of bioorganic chemistry, 31, 3, 256-262. A1 Journal article (refereed), original research

Simplified synthesis of N-(3-[18F]-fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)-nortropane([18F]beta-CFT-FP using [18F]fluoropropyl tosylate as the labelling reagent

Koivula T, Perhola O, Kämäräinen E-L, Lipponen T, Vepsäläinen J, Solin O, 2005, Journal of labelled compounds and radiopharmaceuticals, 48, 463-471. A1 Journal article (refereed), original research

Strategies for organic impurity quantification by 1H NMR spectroscopy: constrained total-line-shape fitting

Soininen P, Haarala J, Vepsäläinen J, Niemitz M, Laatikainen R, 2005, Analytica chimica acta, 542, 2, 178-185. A1 Journal article (refereed), original research

Structures of bisphosphonate metal complexes: zinc and cadmium complexes of clodronate and its partial ester derivatives

Kontturi M, Laurila E, Mattsson R, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Inorganic chemistry, 44, 2400-2406. A1 Journal article (refereed), original research

Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters

Airaksinen AJ, Huotari M, Shvetsov A, Vainiotalo P, Männisto PT, Tuomisto L, Bergström K, Vepsäläinen J, 2005, European journal of medicinal chemistry, 40, 3, 299-304. A1 Journal article (refereed), original research

Synthesis of (R)- and (S)-isomers of 1-methylspermidine

Grigorenko NA, Vepsalainen JJ, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR, 2005, Mendeleev communications, 15, 4, 142-143. A1 Journal article (refereed), original research

Synthesis of 9-[2-O-(2-methoxyethyl)-beta-D-ribofuranosyl]purines using 1-methanesulfonyloxy-2-methoxyethane

Sivets GG, Vepsäläinen J, Mikhailopulo IA, 2005, Letters in organic chemistry, 2, 343-348. A1 Journal article (refereed), original research

Synthesis of novel fatty acid derivatives of etidronic acid

Turhanen PA, Vepsäläinen JJ, 2005, Synthesis: stuttgart, 18, 3063-3066. A1 Journal article (refereed), original research

The first synthesis of novel (1-alkoxycarbonyloxyethylidene)-1,1-bisphosphonic acid derivatives taking advantage of the rearrangement characteristic of the tetramethyl ester of etidronate

Turhanen PA, Vepsäläinen JJ, 2005, Synthesis: stuttgart, 13, 2119-2121. A1 Journal article (refereed), original research

X-ray diffraction study of bisphosphonate metal complexes: Mg and Ca complexes of (dichloromethylene)bisphosphonic acid P,P'-diisopropyl ester

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2005, Polyhedron, 24, 305-309. A1 Journal article (refereed), original research

3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L

Kalinichenko EN, Podkopaeva TL, Budko EV, Seela F, Dong B, Silverman R, Vepsäläinen J, Torrence PF, Mikhailopulo IA, 2004, Bioorganic and medicinal chemistry, 12, 3637-3647. A1 Journal article (refereed), original research

A structural study of bisphosphonate metal complexes - three new polymeric structures of the calcium complex of clodronic acid

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, European journal of inorganic chemistry, 2627-2631. A1 Journal article (refereed), original research

Conformational and biochemical analysis of the cyclic peptides which modulate serine protease activity

Pakkala M, Jylhäsalmi A, Wu P, Leinonen J, Stenman U-H, Santa H, Vepsäläinen J, Peräkylä M, Närvänen A, 2004, Journal of peptide science, 10, 439-447. A1 Journal article (refereed), original research

Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone

Mäntylä A, Rautio J, Nevalainen T, Keski-Rahkonen P, Vepsäläinen J, Järvinen T, 2004, European journal of pharmaceutical sciences, 23, 151-158. A1 Journal article (refereed), original research

Effects of triaryl phosphates on mouse and human nuclear receptors

Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S, 2004, Biochemical pharmacology, 67, 97-106. A1 Journal article (refereed), original research

Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration

Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J, 2004. H1 Granted patent

Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration (in Japanese)

Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J, 2004. H1 Granted patent

One-pot synthesis of 1-[(1-phenyl-1-dialkoxyphosphoryl)-methyl]-2-pyrrolidinone

Turhanen PA, Soininen P, Vepsäläinen JJ, 2004, Letters in organic chemistry, 1, 343-345. A1 Journal article (refereed), original research

Pentaaqua (dichloromethylenebisphosphonato)strontium(II)

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, Acta crystallographica section C : crystal structure communications, E60, m1060-m1062. A1 Journal article (refereed), original research

Poly[[tetraaqua(my7-hydrogen dichloromethylenebisphosphonato)(my5-hydrogen dichloromethylenebisphosphonato)tribarium(II)] monohydrate)

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M, 2004, Acta crystallographica section C : crystal structure communications, C60, m592-m594. A1 Journal article (refereed), original research

Strategies for the preparation of (1-acetyloxyethylidene)-1,1-bisphosphonic acid derivatives

Turhanen PA, Vepsäläinen JJ, 2004, Synthesis: stuttgart, 7, 0992-0994. A1 Journal article (refereed), original research

Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives

Mäntylä A, Rautio J, Nevalainen T, Vepsälainen J, Juvonen R, Kendrick H, Garnier T, Croft SL, Järvinen T, 2004, Bioorganic and medicinal chemistry, 12, 3497-3502. A1 Journal article (refereed), original research

Synthesis of some mono-mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity

Gul HI, Calis U, Vepsäläinen J, 2004, Arzneimittel-forschung-drug research, 54, 7, 359-364. A1 Journal article (refereed), original research

Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone

Mäntylä A, Garnier T, Rautio J, Nevalainen T, Vepsäläinen J, Koskinen A, Croft SL, Järvinen T, 2004, Journal of medicinal chemistry, 47, 188-195. A1 Journal article (refereed), original research

Time-resolved growth behavior of acid aerosols in ethanol vapor with a tandem-DMA technique

Joutsensaari J, Toivonen T, Vaattovaara P, Vesterinen M, Vepsäläinen J, Laaksonen A, 2004, Journal of aerosol science, 35, 851-867. A1 Journal article (refereed), original research

Addition of tert-butylcuprate to (2S)-N-acyl-delta5-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2S,5S)-5-tert-butylproline

Wallén EAA, Christiaans JAM, Gynther J, Vepsäläinen J, 2003, Tetrahedron letters, 44, 2081-2082. A1 Journal article (refereed), original research

Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects

Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J, 2003, European journal of pharmaceutical sciences, 19, 23-29. A1 Journal article (refereed), original research

Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells

Gul HI, Gul M, Vepsälainen J, Erciyas E, Hänninen O, 2003, Biological and pharmaceutical bulletin, 26, 5, 631-637. A1 Journal article (refereed), original research

Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön

Järvinen T, Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, 2003. H1 Granted patent

First synthesis of etidronate partial amides starting from PCI3

Turhanen PA, Niemi R, Peräkylä M, Järvinen T, Vepsäläinen JJ, 2003, Organic and biomolecular chemistry, 1, 3223-3226. A1 Journal article (refereed), original research

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*

Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA, 2003, Journal of biological chemistry, 278, 46, 45915-45923. A1 Journal article (refereed), original research

Reduction of 6/7-substituted 3-phenyltrop-3-en-2-ones: stereoselectivity and conformational analysis of the products

Airaksinen AJ, Lipsonen J, Ahlgren M, Vainiotalo P, Bergström KA, Laatikainen R, Vepsäläinen J, 2003, Tetrahedron, 59, 377-383. A1 Journal article (refereed), original research

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T, 2003, Journal of medicinal chemistry, 46, 5083-5086. A1 Journal article (refereed), original research

A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates

Mäntylä A, Vepsäläinen J, Järvinen T, Nevalainen T, 2002, Tetrahedron letters, 43, 3793-3794. A1 Journal article (refereed), original research

A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism

Räsänen T-L, Alhonen L, Sinervirta R, Keinänen T, Herzig K-H, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J, 2002, Journal of biological chemistry, 277, 42, 39867-39872. A1 Journal article (refereed), original research

A structural study of bisphosphonate metal complexes. Alkaline earth metal complexes of (dichloromethylene)bisphosphonic acid P,P' -diethyl ester

Kontturi M, Vuokila-Laine E, Peräniemi S, Pakkanen TT, Vepsäläinen JJ, Ahlgrén M, 2002, JOURNAL OF THE CHEMICAL SOCIETY. DALTON TRANSACTIONS, 1969-1973. A1 Journal article (refereed), original research

Bisphosphonate prodrugs

Vepsäläinen JJ, 2002, Current medicinal chemistry, 9, 1075-1085. A1 Journal article (refereed), original research

One-pot synthesis of 3,4-disubstituted 1H-pyrroles from 2-tropanones

Airaksinen AJ, Ahlgren M, Vepsäläinen J, 2002, Journal of organic chemistry, 67, 5019-5021. A1 Journal article (refereed), original research

Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2a-(imino-methyl)-3b-(3',4'-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

Yu M, Airaksinen AJ, Gee AD, Lötjönen S, Kuikka JT, Vepsäläinen JJ, Hiltunen J, Bergström KA, 2002, Journal of labelled compounds and radiopharmaceuticals, 45, 1011-1017. A1 Journal article (refereed), original research

Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols

Gul HI, Calis U, Vepsalainen J, 2002, Arzneimittel-forschung-drug research, 52, 12, 863-869. A1 Journal article (refereed), original research

Synthesis of anhydro psicofuranosyl nucleosides

Roivainen J, Vepsäläinen J, Azhayev A, Mikhailopulo IA, 2002, Tetrahedron letters, 43, 6553-6555. A1 Journal article (refereed), original research

Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone

Gul HI, Ojanen T, Vepsalainen J, Gul M, Erciyas E, Hanninen O, 2001, Arzneimittel-forschung-drug research, I, 51, 72-75. A1 Journal article (refereed), original research

Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and X-ray crystallography

Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen JJ, 2001, PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS, 170, 115-133. A1 Journal article (refereed), original research

Bisphosphonate prodrugs: selective synthesis of (1-hydroxyethylidene)-1,1-bisphosphonate partial esters

Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen J, 2001, Synthesis: stuttgart, 4, 633-637. A1 Journal article (refereed), original research

Effect of acetophenone derived Mannich bases on cellular glutathione level in Jurkat cells

Gul M, Gul HI, Vepsalainen J, Erciyas E, Hanninen O, 2001, Arzneimittel-forschung-drug research, 51, II, 679-682. A1 Journal article (refereed), original research

Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells

Raiman J, Niemi R, Vepsäläinen J, Yritys K, Järvinen T, Mönkkönen J, 2001, International journal of pharmaceutics, 213, 135-142. A1 Journal article (refereed), original research

Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography

Tupala E, Kuikka JT, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Hiltunen J, Vepsäläinen J, Tiihonen J, 2001, Neuroimage, 14, 87-94. A1 Journal article (refereed), original research

Novel acid-free cleavage of N-(2-hydroxyarylidene) protected amines

Khomutov AR, Shvetsov AS, Vepsäläinen JJ, Kritzyn AM, 2001, Tetrahedron letters, 42, 2887-2889. A1 Journal article (refereed), original research

A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations

Kovalainen JT, Christiaans JAM, Ropponen R, Poso A, Peräkylä M, Vepsäläinen J, Laatikainen R, Gynther J, 2000, Journal of the American Chemical Society, 122, 29, 6989-6996. A1 Journal article (refereed), original research

Bisphosphonate prodrugs: synthesis and vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate

Niemi R, Turhanen P, Vepsäläinen J, Taipale H, Järvinen T, 2000, European journal of pharmaceutical sciences, 11, 173-180. A1 Journal article (refereed), original research

Conformational flexibility and role of aromatic-aromatic interactions in the crystal packing of the coordination compounds of some novel quadridentate Schiff bases

Pulkkinen JT, Laatikainen R, Ahlgrén MJ, Peräkylä M, Vepsäläinen JJ, 2000, JOURNAL OF THE CHEMICAL SOCIETY. PERKIN 2, 2, 777-784. A1 Journal article (refereed), original research

Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells

Gul HI, Vepsalainen J, Gul M, Erciyas E, Hanninen O, 2000, PHARMACEUTICA ACTA HELVETIAE, 74, 393-398. A1 Journal article (refereed), original research

Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties

Tennilä T, Azhayeva E, Vepsäläinen J, Laatikainen R, Azhayev A, Mikhailopulo IA, 2000, Nucleosides nucleotides and nucleic acids, 19, 10-12, 1861-1884. A1 Journal article (refereed), original research

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, European journal of pharmaceutical sciences, 11, 157-163. A1 Journal article (refereed), original research

Preparation of (18F)beta-CFT-FP and (11C)beta-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)

Kämäräinen E-L, Kyllönen T, Airaksinen A, Lundkvist C, Yu M, Någren K, Sandell J, Langer O, Vepsäläinen J, Hiltunen J, Bergström K, Lötjönen S, Jaakkola T, Halldin C, 2000, Journal of labelled compounds and radiopharmaceuticals, 43, 1235-1244. A1 Journal article (refereed), original research

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T, 2000, Journal of medicinal chemistry, 43, 8, 1489-1494. A1 Journal article (refereed), original research

Synthesis of a water-soluble prodrug of entacapone

Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T, 2000, Bioorganic and medicinal chemistry letters, 10, 1967-1969. A1 Journal article (refereed), original research

Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters

Ahlmark MJ, Vepsäläinen JJ, 2000, Tetrahedron, 56, 5213-5219. A1 Journal article (refereed), original research

Uudet metyleenibisfosfonihappojohdannaiset

Pohjola EK, Vepsäläinen J, Nupponen H, Kähkönen JP, Lauren L, Hannuniemi R, Järvinen TL, Ahlmark MJ, 2000. H1 Granted patent

1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists

Kovalainen JT, Christiaans JAM, Poso A, Vepsäläinen J, Laatikainen R, Gynther J, 1999, Tetrahedron letters, 40, 2425-2428. A1 Journal article (refereed), original research

3rd Spring Meeting on the Division of Synthetic Chemistry Kuopio June 1-2, 1999. Abstracts. 21st Finnish NMR Symposium. Kuopio June 2-4, 1999. Abstracts

Vepsäläinen J, 1999, -. C2 Edited book, conference proceedings or special issue of a journal

Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates

Vepsäläinen JJ, 1999, Tetrahedron letters, 40, 8491-8493. A1 Journal article (refereed), original research

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid

Niemi R, Vepsäläinen J, Taipale H, Järvinen T, 1999, Journal of medicinal chemistry, 42, 24, 5053-5058. A1 Journal article (refereed), original research

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate

Ahlmark M, Vepsäläinen J, Taipale H, Niemi R, Järvinen T, 1999, Journal of medicinal chemistry, 42, 8, 1473-1476. A1 Journal article (refereed), original research

Characterization of a conformationally flexible system: NMR spectroscopic study of 1,5-diphenylpentane-2,4-dione

Pulkkinen JT, Laatikainen R, Vepsäläinen JJ, Ahlgrén MJ, 1999, Magnetic resonance in chemistry, 37, 119-126. A1 Journal article (refereed), original research

Novel methylenebisphosphonic acid derivatives

Pohjola E, Vepsäläinen J, Nupponen H, Kähkönen J, Laurén L, Hannuniemi R, Järvinen T, Ahlmark M, 1999. H1 Granted patent

Nuclear magnetic resonance and molecular orbital study of some cocaine analogues

Airaksinen AJ, Tuppurainen KA, Lötjönen SE, Niemitz M, Yu M, Vepsäläinen JJ, Laatikainen R, Hiltunen J, Bergström KA, 1999, Tetrahedron, 55, 10537-10546. A1 Journal article (refereed), original research

Radiolääkekehitys avaa uusia ikkunoita aivoihin

Bergström K, Airaksinen A, Lötjönen S, Kuikka J, Vepsäläinen J, 1999, Kemia, 26, 5, 391-394. D1 Article in a trade journal

Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid as novel naproxen prodrugs for dermal drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T, 1999, Pharmaceutical research, 16, 8, 1172-1178. A1 Journal article (refereed), original research

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel partial amides of clodronic acid

Niemi R, Pennanen H, Vepsäläinen J, Taipale H, Järvinen T, 1998, International journal of pharmaceutics, 174, 111-115. A1 Journal article (refereed), original research

In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen

Rautio J, Taipale H, Gynther J, Vepsäläinen J, Nevalainen T, Järvinen T, 1998, Journal of pharmaceutical sciences, 87, 12, 1622-1628. A1 Journal article (refereed), original research

Complete spectral analysis of the 1H NMR 16-spin system of beta-pinene

Kolehmainen E, Laihia K, Laatikainen R, Vepsäläinen J, Niemitz M, Suontamo R, 1997, Magnetic resonance in chemistry, 35, 463-467. A1 Journal article (refereed), original research

Identification of a common structural motif in the disordered N-terminal region of bacterial flagellins Evidence for a new class of fibril-forming peptides

Hakalehto E, Santa H, Vepsäläinen J, Laatikainen R, Finne J, 1997, Febs journal, 250, 19-29. A1 Journal article (refereed), original research

Preparation and identification of tetraamide esters of methylene- and (dichloromethylene)bisphosphonates

Vepsäläinen J, Vainiotalo P, Nupponen H, Pohjola E, 1997, ACTA CHEMICA SCANDINAVICA, 51, 932-937. A1 Journal article (refereed), original research

Simultaneous determination of clodronate and its partial ester derivatives by ion-pair reversed-phase high-performance liquid chromatography coupled with evaporative light-scattering detection

Niemi R, Taipale H, Ahlmark M, Vepsäläinen J, Järvinen T, 1997, Journal of chromatography b: analytical technologies in the biomedical and life sciences, 701, 97-102. A1 Journal article (refereed), original research

Strategies for the selective synthesis of monosubstituted (dichloromethylene)bisphosphonate esters

Ahlmark MJ, Vepsäläinen JJ, 1997, Tetrahedron, 53, 47, 16153-16160. A1 Journal article (refereed), original research

3-unsubstituted 1,5-Diaryl-2,4-pentanediones and -4-methoxy-2- pentanones: Synthesis via corresponding 3-hydroxy ketones generated from 2-isoxazolines

Pulkkinen JT, Vepsäläinen JJ, 1996, Journal of organic chemistry, 61, 8604-8609. A1 Journal article (refereed), original research

Bisphosphonic compounds VIII. A facile and selective one-pot synthesis of P,P-dialkyl (dichloromethylene)bisphosphonate partial esters

Vepsäläinen J, Nupponen H, Pohjola E, 1996, Tetrahedron letters, 37, 20, 3533-3536. A1 Journal article (refereed), original research

General strategies for total-lineshape-type spectral analysis of NMR spectra using integral-transform iterator

Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T, Vepsäläinen J, 1996, JOURNAL OF MAGNETIC RESONANCE (A), 120, 1-10. A1 Journal article (refereed), original research

New aminooxy analogs of biogenic polyamines (in Russian)

Khomutov AR, Shvetsov AS, Vepsalainen J, Kramer DL, Hyvonen T, Keinanen T, Eloranta TO, Porter CW, Khomutov RM, 1996, Bioorganicheskaya khimiya, 22, 7, 557-559. A1 Journal article (refereed), original research

Performic acid oxidation of exo-2-syn-7-bicyclo[2.2.1]hept-5-enediol. 1H and 13C NMR spectroscopic structure elucidation of the reaction products

Laihia K, Kolehmainen E, Mänttäri P, Ryynänen R, Messala-Rannanpiha M, Vepsäläinen J, Sundelin J-P, 1996, Spectrochimica acta part a: molecular and biomolecular spectroscopy, 51, 495-504. A1 Journal article (refereed), original research

Preparation and structure determination of 1-benzyl-, 1-methyl- and 1H-5-[(nitro-2-phenyl)ethenyl]imidazoles

Aulaskari P, Ahlgrén M, Rouvinen J, Vainiotalo P, Pohjala E, Vepsäläinen J, 1996, Journal of heterocyclic chemistry, 33, 1345-1354. A1 Journal article (refereed), original research

Synthesis of hydroxylamine analogues of polyamines

Khomutov AR, Vepsäläinen JJ, Shvetsov AS, Hyvönen T, Keinänen TA, Pustobaev VN, Eloranta TO, Khomutov RM, 1996, Tetrahedron, 52, 43, 13751-13766. A1 Journal article (refereed), original research

An improved synthetic method and the first crystal structures for (dihalomethylene)bisphosphonate partial esters

Vepsäläinen JJ, Kivikoski J, Ahlgrén M, Nupponen HE, Pohjola EK, 1995, Tetrahedron, 51, 24, 6805-6818. A1 Journal article (refereed), original research

Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions

Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A, 1995, Journal of pharmaceutical sciences, 84, 5, 656-660. A1 Journal article (refereed), original research

Conformationally biased tri- and di-basic 1,3,5-triazacyclohexyl ligands

Angelis de S, Batsanov A, Norman TJ, Parker D, Senanayake K, Vepsalainen J, 1995, Chemical communications, 2361-2363. A1 Journal article (refereed), original research

Synthesis of a tritium labelled antihistaminic drug [3H]-N,N-diethyl-2-[4-(phenylmethylphenoxy]-ethaneamine * HCl

Kovalainen JT, Morimoto H, Williams PG, Vepsäläinen J, Reijonen A, Gynther J, 1995, Journal of labelled compounds and radiopharmaceuticals, 36, 12, 1147-1156. A1 Journal article (refereed), original research

A general route to 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones

Pulkkinen, Juha; Vepsäläinen, Jouko; Laatikainen, Reino, 1994, Tetrahedron letters, 35, 52, 9749-9750. A1 Journal article (refereed), original research

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A study protocol for chemical analysis and toxicity testing of virgin and recycled microplastics and associated chemicals

Advancements and feasibility of synergistic approaches in phosphorus recovery from wastewater: A critical review

Bisphosphonate functionalized biogenic nanostructured silicon carbide for uranium and scandium recovery

Urinary levels of oestradiol and pregnanediol glucuronides reflect the ovarian function in the domestic dog (Canis familiaris)

17O NMR spectroscopy protocol for the determination of water content in liquids produced by pyrolysis and hydrothermal liquefaction

Catalytic action of hydronium-ion in rice straw pretreatment and enhancement of enzymatic hydrolysis and ethanol production

Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses

Scent Detection Threshold of Trained Dogs to Eucalyptus Hydrolat

Farmaseuttinen kemia

Mikromuovien analytiikan ja poistomenetelmien kehittäminen teollisuuden laadunvalvontaan

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Syljen metabolomiikan sovellutuksia suulääketieteellisessä tutkimuksessa

Valorization potential of the aqueous products from hydrothermal liquefaction and stepwise slow pyrolysis of wood bark and hemp hurds with yields and product comparison

Effects of tree harvesting time and tannin cold/hot-water extraction procedures on the performance of spruce tannin biocoagulant for water treatment

Functionalized nanoporous silicon for extraction of Sc from a leach solution

Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X-ray Fluorescence (pXRF) System

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots

Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture

Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria

Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel

Effect of solvent mixture pretreatment on sugar release from short-rotation coppice Salix schwerinii for biobutanol production

Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus

Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds

Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption

Recovery of uranium with bisphosphonate modified mesoporous silicon

Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms

Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams

Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing

Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process

Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum

Rapid synthesis of nanostructured porous silicon carbide from biogenic silica

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

Bisphosphonate modified mesoporous silicon for scandium adsorption

Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils

Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation

Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach

Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase

Altered polyamine profiles in colorectal cancer

Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement

Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production

Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement

On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge

Urinary Polyamines as Biomarkers for Ovarian Cancer

Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase

Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach

Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

A powerful tool for acid catalyzed organic addition and substitution reactions

Advanced material and approach for metal ions removal from aqueous solutions

Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

Enantioselective synthesis of (R)- and (S)-3-methylspermidines

Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives

Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters

Synthesis of biologically active analogues of spermine and spermidine

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Urinary acetylated polyamines in ovarian cancer

Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence

Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques

Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production