Kai Kaarniranta

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. Cells 10 6: 1405. 2021

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells

Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu. Antioxidants 10 1: 67. 2021

Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α

Blasiak, J; Szczepanska, J; Fila, M; Pawlowska, E; Kaarniranta, K. International journal of molecular sciences 22 13: 7194. 2021

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Blasiak, Janusz; Hyttinen, Juha M. T.; Szczepanska, Joanna; Pawlowska, Elzbieta; Kaarniranta, Kai. International journal of molecular sciences 22 17: 9178. 2021

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Blasiak, Janusz; Koskela, Ali; Pawlowska, Elzbieta; Liukkonen, Mikko; Ruuth, Johanna; Toropainen, Elisa; Hyttinen, Juha MT; Viiri, Johanna; Eriksson, John E.; Xu, Heping; Chen, Mei; Felszeghy, Szabolcs; Kaarniranta, Kai. International journal of molecular sciences 22 4: 1684. 2021

Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study

de Mello, Vanessa Derenji; Selander, Tuomas; Lindström, Jaana; Tuomilehto, Jaakko; Uusitupa, Matti; Kaarniranta, Kai. Nutrients 13 12: 4452. 2021

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myöhänen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto. Biomedicine and pharmacotherapy 2022; 146: 112501. 2021

Incidence of cataract surgeries in people with and without Alzheimer's disease

Hokkinen, K; Kaarniranta, K; Jämsen, E; Lampela, P; Hartikainen, S; Tolppanen, AM. Acta ophthalmologica 2022; 100 1: 68-73. 2021

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu. International journal of molecular sciences 22 13: 6800. 2021

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

Hyttinen, Juha M T; Blasiak, Janusz; Felszeghy, Szabolcs; Kaarniranta, Kai. Ageing research reviews 67: 101260. 2021

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Hyttinen, Juha; Blasiak, Janusz; Tavi, Pasi; Kaarniranta, Kai. Expert opinion on therapeutic targets 25 9: 773-785. 2021

Successful years of collaboration between Acta Ophthalmologica and the European Association for Vision and Eye Research

Kaarniranta, Kai; Stefansson, Einar. Acta ophthalmologica 99 3: 239. 2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Ha. Autophagy 17 1: 1-382. 2021

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu. Experimental eye research 209: 108687. 2021

Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population

Liuska, PJ; Lemmelä, S; Havulinna, AS; Kaarniranta, K; Uusitalo, H; Laivuori, H; Kiiskinen, T; Daly, MJ; Palotie, A; Turunen, JA. JAMA ophthalmology 139 7: 762-768. 2021

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu. International journal of molecular sciences 22 9: 4875. 2021

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Rousou, Charis; Schuurmans, Carl C. L.; Urtti, Arto; Mastrobattista, Enrico; Storm, Gert; Moonen, Chrit; Kaarniranta, Kai; Deckers, Roel. Pharmaceutics 13 11: 1782. 2021

Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Neurochemistry international 150: 105186. 2021

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Inflammation research 70 10-12: 1043-1061. 2021

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai. Biology 10 7: 622. 2021

Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization

Winiarczyk, Mateusz; Winiarczyk, Dagmara; Michalak, Katarzyna; Kaarniranta, Kai; Adaszek, Lukasz; Winiarczyk, Stanislaw; Mackiewicz, Jerzy. Journal of clinical medicine 10 14: 3060. 2021

Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation

Amirkavei, Mooud; Pitkänen, Marja; Kaikkonen, Ossi; Kaarniranta, Kai; André, Helder; Koskelainen, Ari. International journal of molecular sciences 21 6: 2063. 2020

Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment

Balogh, Anikó; Milibák, Tibor; Szabó, Viktória; Nagy, Zoltán Zsolt; Kaarniranta, Kai; Resch, Miklós D. Bmc ophthalmology 20 2: 491. 2020

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Koskela, Ali; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu. International journal of molecular sciences 21 6: 2066. 2020

Zinc and Autophagy in Age-Related Macular Degeneration

Blasiak, Janusz; Pawlowska, Elzbieta; Chojnacki, Jan; Szczepanska, Joanna; Chojnacki, Cezary; Kaarniranta, Kai. International journal of molecular sciences 21 14: 4994. 2020

The Aging Stress Response and Its Implication for AMD Pathogenesis

Blasiak, Janusz; Pawlowska, Elzbieta; Sobczuk, Anna; Szczepanska, Joanna; Kaarniranta, Kai. International journal of molecular sciences 21 22: 8840. 2020

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

Hellinen, Laura; Hongisto, Heidi; Ramsay, Eva; Kaarniranta, Kai; Vellonen, Kati-Sisko; Skottman, Heli; Ruponen, Marika. Pharmaceutics 12 2: 176. 2020

In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby Fundus Dystrophy

Hongisto, H; Dewing, JM; Christensen, DRG; Scott, J; Cree, AJ; Nättinen, J; Määttä, J; Jylhä, A; Aapola, U; Uusitalo, H; Kaarniranta, K; Ratnayaka, JA; Skottman, H; Lotery, AJ. Journal of pathology 252 2: 138-150. 2020

Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells

Josifovska, N; Albert, R; Nagymihály, R; Lytvynchuk, L; Moe, MC; Kaarniranta, K; Veréb, ZJ; Petrovski, G. International journal of molecular sciences 21 3: 813. 2020

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation

Kaarniranta, Kai; Pawlowska, Elzbieta; Szczepanska, Joanna; Blasiak, Janusz. Aging and disease 11 4: 851-862. 2020

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah. Progress in retinal and eye research 78: 100858. 2020

Correlation Between the Rate of Intravitreal Injections, Use of Aflibercept as a Second-Line Treatment and Visual Impairment for Wet AMD in Finland

Karesvuo, Petteri; Hakkala, Laura; Kaarniranta, Kai; Uusitalo, Hannu; Ojamo, Matti; Tuuminen, Raimo. Acta ophthalmologica 98 5: 472-476. 2020

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero. Frontiers in immunology 11: 384. 2020

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu. Investigative ophthalmology and visual science 61 4: 7. 2020

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu. Faseb journal 34 5: 6437-6448. 2020

Trehalose for Ocular Surface Health

Laihia, Jarmo; Kaarniranta, Kai. Biomolecules 10 5: 809. 2020

Yhtenäiset vaatimukset lääketieteen ja hammaslääketieteen tohtorintutkinnolle Suomessa

Lehenkari, Petri; Tuovinen, Timo; Alahuhta, Seppo; Risteli, Leila; Ylöstalo, Pekka; Rämet, Mika; Parkkila, Seppo; Happo, Saara; Kaarniranta, Kai; Blom, Nina; Ritvos, Olli; Kähäri, Veli-Matti; Leivo, Ilmo; Heikinheimo, Markku. Duodecim 136 6: 633-640. 2020

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

Paterno, Jussi J; Koskela, Ali; Hyttinen, Juha M T; Vattulainen, Elina; Synowiec, Ewelina; Tuuminen, Raimo; Watala, Cezary; Blasiak, Janusz; Kaarniranta, Kai. Genes 11 11: 1318. 2020

ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Journal of molecular medicine: jmm 98: 633-650. 2020

Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Cellular signalling 75: 109771. 2020

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai. International journal of molecular sciences 21 6: 1976. 2020

Comparison of Two Different Treat-and-Extend Protocols with Afibercept in Wet Age-Related Macular Degeneration: Two-Year Results

Taipale, Claudia; Lindholm, Juha-Matti; Kaarniranta, Kai; Tuuminen, Raimo. Advances in therapy 37: 2256-2266. 2020

The role of vision-related problems in fatal road accidents in Finland

Wedenoja, Juho; Kalsi, Juhani; Salenius, Salla; Parkkari, Kalle; Kaarniranta, Kai; Tervo, Timo. Acta ophthalmologica 2021; 99 4: 427-430. 2020

Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study

Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K. Nutrients 11 7: 1691. 2019

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration

Blasiak, J; Pawlowska, E; Szczepanska, J; Kaarniranta, K. International journal of molecular sciences 20 1: 210. 2019

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Blasiak, J; Watala, C; Tuuminen, R; Kivinen, N; Koskela, A; Uusitalo-Järvinen, H; Tuulonen, A; Winiarczyk, M; Mackiewicz, J; Zmorzynski, S; Filip, A; Kaarniranta, K. Journal of cellular and molecular medicine 23 12: 8464-8471. 2019

Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study

Bourne, RRA; Kaarniranta, K; Lorenz, K; Traverso, CE; Vuorinen, J; Ropo, A. BMJ open 9: e024129. 2019

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu. Oxidative medicine and cellular longevity 2019: 1583656. 2019

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

Hyttinen, JMT; Kannan, R; Felszeghy, S; Niittykoski, M; Salminen, A; Kaarniranta, K. International journal of molecular sciences 20 22: 5800. 2019

Can vitamin D protect against age-related macular degeneration or slow its progression?

Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. Acta biochimica polonica 66 2: 147-158. 2019

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD).

Kaarniranta, K; Pawlowska, E; Szczepanska, J; Jablkowska, A; Blasiak, J. International journal of molecular sciences 20 10: 2374. 2019

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu. Biochimie 159: 49-54. 2019

Real Life Experience of Dexamethasone Implant in Refractory Diabetic Macular Oedema

Karttunen, Tommi; Nummelin, Lasse; Kaarniranta, Kai; Kinnunen, Kati. Clinical ophthalmology 13: 2583-2590. 2019

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

Kiamehr, M; Klettner, A; Richert, E; Koskela, A; Koistinen, A; Skottman, H; Kaarniranta, K; Aalto-Setälä, K; Juuti-Uusitalo, K. International journal of molecular sciences 20 15: 3773. 2019

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A. Cytokine 116: 70-77. 2019

Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial

Laihia, J; Järvinen, R; Wylegala, E; Kaarniranta, K. Acta ophthalmologica 2020; 98 3: 244-254. 2019

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Pawlowska, E; Szczepanska, J; Koskela, A; Kaarniranta, K; Blasiak, J. Oxidative medicine and cellular longevity 2019: 9682318. 2019

Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells

Bhattarai, Niina; Korhonen, Eveliina; Toppila, Maija; Kaarniranta, Kai; Kauppinen, Anu. Acta ophthalmologica. 2019. 2019

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Cellular and molecular life sciences 76 10: 1901-1918. 2019

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. Journal of molecular medicine: jmm 97 8: 1049-1064. 2019

Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function

Smedowski, A; Akhtar, S; Liu, X; Pietrucha-Dutczak, M; Podracka, L; Toropainen, E; Alkanaan, A; Ruponen, M; Urtti, A; Varjosalo, M; Kaarniranta, K; Lewin-Kowalik, J. Acta ophthalmologica [Epub ahead of print 10 Oct 2019]: 1-10. 2019

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G. International journal of molecular sciences 20 4: 926. 2019

The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration

Tuuminen, R; Sipilä, R; Komulainen, J; Saarela, V; Kaarniranta, K; Tuulonen, A. Acta ophthalmologica 97 5: e808-e810. 2019

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG. Journal of molecular medicine: jmm 97 3: 341-354. 2019

Molecular Mechanisms Underlying Age-Related Ocular Diseases

Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. Oxidative Medicine and Cellular Longevity 2018: 1-2. 2018

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A]. Redox biology 2019; 20: 1-12. 2018

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Hyttinen, Juha MT; Viiri, Johanna; Kaarniranta, Kai; Blasiak, Janusz. Cellular and molecular life sciences 75 16: 2991-3008. 2018

Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits

Ilmarinen, T; Thieltges, F; Hongisto, H; Juuti-Uusitalo, K; Koistinen, A; Kaarniranta, K; Brinken, R; Braun, N; Holz, FG; Skottman, H; Stanzel, BV. Acta ophthalmologica 2019; 97 5: e688-e699. 2018

Bestin tauti

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 194-195. 2018

Fluoreseiiniangiografia (FAG)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 394-395. 2018

Fotodynaaminen hoito (PDT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 422. 2018

Mikrobinäytteen otto silmästä

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 407-409. 2018

Optinen valokerroskuvaus (OCT)

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 396-397. 2018

Silmänpohjan ikärappeumat

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 192-194. 2018

Verkkokalvohalkio

Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 182-183. 2018

PGC-1alfa Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis

Kaarniranta, Kai; Kajdanek, Jakub; Morawiec, Jan; Pawlowska, Elzbieta; Blasiak, Janusz. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 8: 2317. 2018

Leikkauksenjälkeisen silmämunan sisäosien yleistulehduksen hoito

Kaarniranta, Kai; Marttila, Liisa; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 185-188. 2018

Mechanistical retinal drug targets and challenges

Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu. Advanced drug delivery reviews 126: 177-184. 2018

Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage

Khamidakh, Amna E Abu; Rodriguez-Martinez, Alejandra; Kaarniranta, Kai; Kallioniemi, Anne; Skottman, Heli; Hyttinen, Jari; Juuti-Uusitalo, Kati. Biomedical engineering online 17: 102. 2018

Seroosi retinopatia, nesteinen keskeisen verkkokalvon sairaus

Kivinen, Niko; Kaarniranta, Kai. Lääkärilehti 73 36: 1940-1943. 2018

Verkkokalvon keskeinen nesteirtauma

Kivinen, Niko; Kaarniranta, Kai; Seppänen, Matti. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 184-185. 2018

Silmänpohjan kuvantaminen yleistyy ja tarkentuu

Kivinen, Niko; Tuulonen, Anja; Kaarniranta, Kai. Duodecim 134 12: 1235-1243. 2018

Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats

Lappalainen, J; Oksala, NKJ; Laaksonen, DE; Khanna, S; Kokkola, T; Kaarniranta, K; Sen, CK; Atalay, M. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 28 7: 1808-1817. 2018

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura. Oxidative medicine and cellular longevity 2018: 4956080. 2018

Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A. Scientific Reports 8: 6720. 2018

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu. Cellular physiology and biochemistry 49 1: 359-367. 2018

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice

Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. CARDIOVASCULAR RESEARCH 2019; 115 1: 243-254. 2018

Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. International Immunopharmacology 61: 231-240. 2018

The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. Cellular and molecular life sciences 75 17: 3099-3120. 2018

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu. AGEING RESEARCH REVIEWS 48: 1-10. 2018

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai. Biogerontology 19 5: 325-329. 2018

Atselastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 469. 2018

Atsitromysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 434. 2018

Dinatriumkromoglikaatti

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 470-471. 2018

Emedastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 470. 2018

Fluorokinolonit

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 434-435. 2018

Fusidiinihappo

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 435-436. 2018

Gansikloviiri

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 436-437. 2018

Kefuroksiimi

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 437. 2018

Klooritetrasykliini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 437-438. 2018

Kloramfenikoli

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 438-439. 2018

Levokabastiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 471-472. 2018

Lodoksamidi

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 472. 2018

Natamysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 439-440. 2018

Olopatadiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 472-473. 2018

Propamidiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 440. 2018

Siklosporiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 480-481. 2018

Tobramysiini

Seppänen, Matti; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 440-441. 2018

Ajokorttitodistusten näkövaatimukset

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 376. 2018

Silmävärve (nystagmus)

Seppänen, Matti; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 290-291. 2018

Asikloviiri

Seppänen, Matti; Setälä, Niko; Kaarniranta, Kai. Teoksessa: Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu (toim.) Silmätautien käsikirja. Duodecim. s. 433-434. 2018

Silmätautien käsikirja

Seppänen, Matti; Holopainen, Juha; Kaarniranta, Kai; Setälä, Niko; Uusitalo, Hannu. 2018 2018

Special issue on Molecular Mechanisms Underlying Age-Related Ocular Diseases

Amadio, Marialaura; Kaarniranta, Kai; Xu, Heping; Smedowski, Adrian; Ferrington, Deborah A. 2018 2018

Tear film proteome in age-related macular degeneration

Winiarczyk, Mateusz; Kaarniranta, Kai; Winiarczyk, Stanislaw; Adaszek, Lukasz; Winiarczyk, Dagmara; Mackiewicz, Jerzy. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 256 6: 1127-1139. 2018

Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells

Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 9: 1757-1762. 2017

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Blasiak Janusz, Piechota Malgorzata, Pawlowska Elzbieta, Szatkowska Magdalena, Sikora Ewa, Kaarniranta Kai. Oxidative Medicine and Cellular Longevity 2017: 5293258. 2017

Individual benefits of enoxaparin treatment in branch vein occlusion

Dragoni, Francesco; Kaarniranta, Kai. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 2018; 256 5: 1031-1033. 2017

Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients

Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. ACTA OPHTHALMOLOGICA 95 4: 378-385. 2017

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A. Scientific Reports 7 1: 16169. 2017

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 42: 37-42. 2017

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)

Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K. AGEING RESEARCH REVIEWS 36: 64-77. 2017

Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model

Jauhonen HM, Laihia J, Oksala O, Viiri J, Sironen R, Alajuuma P, Kaarniranta K, Leino L. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 255 12: 2357-2362. 2017

Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 5: 1089. 2017

The Nobel Prized cellular target autophagy in eye diseases

Kaarniranta Kai, Petrovski Goran, Kauppinen Anu. ACTA OPHTHALMOLOGICA 95 4: 335-336. 2017

Outcome of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration in real-life setting

Kataja, M; Hujanen, P; Huhtala, H; Kaarniranta, K; Tuulonen, A; Uusitalo-Jarvinen, H. British journal of ophthalmology 2018; 102 7: 959-965. 2017

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)

Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A. Journal of Cell Communication and Signaling 11 3: 275-279. 2017

Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua

Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai. DUODECIM 133 7: 641-646. 2017

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy

Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A. ACTA OPHTHALMOLOGICA 95 8: 803-808. 2017

Predictive factors in endonasal endoscopic lacrimal surgery: a review

Penttilä E, Smirnov G, Kaarniranta K, Seppä J, Tuomilehto H. B-ENT 13: 129-135. 2017

Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy

Petrovski G, Kaarniranta K, Petrovic D. Journal of Diabetes Research [Published online 2017 Feb 22]: 1-2. 2017

Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model

Roginska Dorota, Kawa Milosz P, Pius-Sadowska Ewa, Lejkowska Renata, Luczkowska Karolina, Wiszniewska Barbara, Kaarniranta Kai, Paterno Jussi J, Schmidt Christian A, Machalinski Boguslaw, Machalinska Anna. Oxidative medicine and cellular longevity 2017: 5306790. 2017

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen A, Kaarniranta K, Kauppinen A. CELLULAR SIGNALLING 40: 10-21. 2017

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. AGEING RESEARCH REVIEWS 37: 79-93. 2017

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. JOURNAL OF NEUROCHEMISTRY 140 4: 536-549. 2017

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells

Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. EXPERIMENTAL CELL RESEARCH 359 1: 101-111. 2017

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells : a possible sign of endogenous neuroprotection failure

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M. Biochimica et Biophysica Acta: Molecular Basis of Disease 2018; 1864 1: 296-306. 2017

Cytoarchitecture of epithelial inflammatory infiltration indicates the aetiology of infectious keratitis

Smedowski A, Tarnawska D, Orski M, Wroblewska-Czajka E, Kaarniranta K, Aragona P, Wylegala E. ACTA OPHTHALMOLOGICA 95 4: 405-413. 2017

The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration

Tuuminen R, Tuulonen A, Kaarniranta K. ACTA OPHTHALMOLOGICA 95 7: 649-650. 2017

The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age related macular degeneration

Tuuminen Raimo, Uusitalo-Järvinen Hannele, Aaltonen Vesa, Hautala Nina, Kaipiainen Sulevi, Laitamäki Nina, Ollila Marko, Rantanen Jari, Välimäki Satu, Sipilä Raija, Laukkala Tanja, Komulainen Jorma, Tommila Petri, Immonen Ilkka, Tuulonen Anja, Kaarniranta Kai. ACTA OPHTHALMOLOGICA 95 A105: 1-9. 2017

Visual processing in patients with age-related macular degeneration performing a face detection test

Vottonen Pasi, Kaarniranta Kai, Pääkkönen Ari, Tarkka Ina M. Clinical Ophthalmology 11: 1245-1252. 2017

Melatonin in retinal physiology and pathology: the case of age-related macular degeneration

Blasiak J, Reiter RJ, Kaarniranta K. Oxidative Medicine and Cellular Longevity 2016: 6819736, 12 pages. 2016

Dry Eye Disease - Nordic Guidelines 2016

Heegaard S, Knudsen LL, van Setten G, Koranyi G, Holopainen J, Kaarniranta K, Klyve P, Raeder S. 2016 2016

Inhibition of BET bromodomains alleviates inflammation in human RPE cells

Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu. BIOCHEMICAL PHARMACOLOGY 110-111: 71-79. 2016

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration

Kaarniranta K, Tokarz P, Koskela A, Paterno J, Blasiak J. Cell biology and toxicology 2017; 33: 113-128. 2016

Lääketieteen Nobelin palkinto autofagian tutkijalle

Kaarniranta Kai, Meri Seppo, Eskelinen Eeva-Liisa. DUODECIM 132 22: 2141-2144. 2016

Inflammation and its role in age-related macular degeneration

Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai. Cellular and molecular life sciences 73 9: 1765-1786. 2016

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai. BIOGERONTOLOGY 17 4: 749-761. 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky Daniel J, Abdelmohsen Kotb, Abe Akihisa, Abedin Md Joynal, Abeliovich Hagai, Acevedo Arozena Abraham, Adachi Hiroaki, Adams Christopher M, Adams Peter D, Adeli Khosrow, Adhihetty Peter J, Adler Sharon G, Agam Galila, Agarwal Rajesh, Aghi Manish K, Agnello Maria, Agostinis Patrizia, Aguilar Patricia V, Aguirre-Ghiso Julio, Airoldi Eduardo M et al. AUTOPHAGY 12 1: 1-222. 2016

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

Koskela Ali, Reinisalo Mika, Petrovski Goran, Sinha Debasish, Olmiere Céline, Karjalainen Reijo, Kaarniranta Kai. Nutrients 8 5: 284. 2016

Nya behandlingar vid synhotande makulasjukdomer

Paterno J, Ikäheimo K, Kinnunen K, Kaarniranta K. Finska läkaresällskapets handlingar 176 1: 10-14. 2016

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. AGEING RESEARCH REVIEWS 28: 15-26. 2016

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. BIOGERONTOLOGY 17 4: 655-680. 2016

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases

Salminen Antero, Kaarniranta Kai, Kauppinen Anu. Aging and disease 7 2: 180-200. 2016

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. CELLULAR SIGNALLING 28 8: 887-895. 2016

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. JOURNAL OF MOLECULAR MEDICINE 2017; 95 2: 123-131. 2016

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration

Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G. Cell Death and Disease 7 9: e2367. 2016

Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes

Tokarz Paulina, Kaarniranta Kai, Blasiaka Janusz. EUROPEAN JOURNAL OF PHARMACOLOGY 776: 167-175. 2016

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

Tokarz Paulina, Piastowska-Ciesielska Agnieszka Wanda, Kaarniranta Kai, Blasiak Janusz. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17 6: 898. 2016

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa

Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian. European journal of pharmacology 788: 12-20. 2016

Kostea silmänpohjan ikärappeuma (AMD)

Tuuminen R, Uusitalo-Järvinen H, Aaltonen V, Hautala N, Kaipiainen S, Laitamäki N, Ollila M, Rantanen J, Välimäki S, Sipilä R, Laukkala T, Komulainen J, Tommila P, Immonen I, Tuulonen A, Kaarniranta K. Teoksessa: - (toim.) Käypä hoito. Suomalaisen Lääkäriseuran Duodecimin ja Suomen Fysiatriyhdistyksen asettama työryhmä. Duodecim. s. -. 2016

Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials

Uusitalo Hannu, Egorov Evjeniy, Kaarniranta Kai, Astakhov Yuri, Ropo Auli. Clinical Ophthalmology 10: 445-454. 2016

Autophagy in DNA Damage Response

Czarny Piotr, Pawlowska Elzbieta, Bialkowska-Warzecha Jolanta, Kaarniranta Kai, Blasiak Janusz. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16 2: 2641-2662. 2015

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

Ferrington Deborah A, Sinha Debasish, Kaarniranta Kai. PROGRESS IN RETINAL AND EYE RESEARCH 2016; 51: 69-89. 2015

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation

Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. Scientific Reports 5 17645 (2015). 2015

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu. EXPERIMENTAL EYE RESEARCH 132: 208-215. 2015

A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects

Jauhonen Hanna-Mari, Kari Eeva, Pylkkänen Liisa, Poutanen Jutta, Laihia Jarmo, Kaarniranta Kai, Leino Lasse. ACTA OPHTHALMOLOGICA 93 4: 368-376. 2015

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

Johansson Ida, Monsen Vivi Talstad, Pettersen Kristine, Mildenberger Jennifer, Misund Kristine, Kaarniranta Kai, Schønberg Svanhild, Bjørkøy Geir. AUTOPHAGY 11 9: 1636-1651. 2015

Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015 % and Timolol 0.5 % in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies

Kaarniranta Kai, Ikäheimo Kirsi, Mannermaa Eliisa, Ropo Auli. CLINICAL PHARMACOKINETICS [epub ahead of print 21 Sep 2015]: 1-10. 2015

A novel proteotoxic stress associated mechanism for macular corneal dystrophy

Kaarniranta Kai, Szalai Eszter, Smedowski Adrian, Hegyi Zoltán, Kivinen Niko, Viiri Johanna, Wowra Bogumil, Dobrowolski Dariusz, Módis Jr. László, Berta András, Wylegala Edward, Felszeghy Szabolcs. HISTOLOGY AND HISTOPATHOLOGY 30: 921-930. 2015

Diabeettisen retinopatian uudet hoidot ja diagnostiikka

Karttunen Tommi, Kaarniranta Kai, Kinnunen Kati. DIABETES JA LÄÄKÄRI 44 4 (syyskuu): 17-22. 2015

Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment

Lumi Xhevat, Hawlina Marko, Glavac Damjan, Facsko Andrea, Moe Morten C, Kaarniranta Kai, Petrovski Goran. AGEING RESEARCH REVIEWS 21: 71-77. 2015

Endoscopic dacryocystorhinostomy as treatment for lower lacrimal pathway obstructions in adults : Review article

Penttilä Elina, Smirnov Grigori, Tuomilehto Henri, Kaarniranta Kai, Seppä Juha. Allergy and Rhinology 6 1: e12-e19. 2015

Health-related quality of life after caract surgery with the phacoemulsification technique and intraocular lens implantation

Porela-Tiihonen Susanna, Roine Risto P, Sintonen Harri, Kaarniranta Kai, Kokki Merja, Kokki Hannu. ACTA OPHTHALMOLOGICA 2016; 94 1: 21-25. 2015

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo Mika, Kårlund Anna, Koskela Ali, Kaaniranta Kai, Karjalainen Reijo O.. Oxidative Medicine and Cellular Longevity 2015, Article ID 340520: 24 p.. 2015

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. PROGRESS IN NEUROBIOLOGY epub ahead of print 19 May 2015. 2015

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Salminen Antero, Kauppinen Anu, Kaarniranta Kai. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 72 20: 3897-3914. 2015

Climatic droplet keratopathy: an old disease in new clothes

Serra Horacio M, Holopainen Juha M, Beuerman Roger, Kaarniranta Kai, Suarez Maria F, Urrets-Zavalia Julio A. ACTA OPHTHALMOLOGICA 93 6: 496-504. 2015

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

Sinha Debasish, Valapala Mallika, Shang Peng, Hose Stacey, Grebe Rhonda, Lutty Gerard A, Zigler Jr J Samuel, Kaarniranta Kai, Handa James T. EXPERIMENTAL EYE RESEARCH 144 (2016): 46-53. 2015

Role of the cell cycle re-initiation in DNA damage response of post-mitotic cells and its implication in the pathogenesis of neurodegenerative diseases

Tokarz Paulina, Kaarniranta Kai, Blasiak Janusz. REJUVENATION RESEARCH 19 2: 1-9. 2015

Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients

Vottonen Pasi, Pääkkönen Ari, Tarkka Ina M, Kaarniranta Kai. ACTA OPHTHALMOLOGICA 93 7: 621-25. 2015

Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture

Aaltonen Vesa, Kinnunen Kati, Jouhilahti Eeva-Mari, Peltonen Juha, Nikinmaa Mikko, Kaarniranta Kai, Arjamaa Olli. ACTA OPHTHALMOLOGICA 92 8: 740-744. 2014

Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration

Blasiak Janusz, Petrovski Goran, Veréb Zoltan, Facskó Andrea, Kaarniranta Kai. BioMed Research International 2014: 1-7. 2014

ADAMTS9 locus associates with increased risk of wet AMD

Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. ACTA OPHTHALMOLOGICA 2014: 1. 2014

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. AGEING RESEARCH REVIEWS 18: 16-28. 2014

Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration

Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu. CURRENT EYE RESEARCH 2014: 1-8. 2014

CB2 receptor as a potential target in age-related diseases

Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija. Journal of Biochemical and Pharmacological Research 2 1: 33-43. 2014

Oxidative stress plays an important role in zoledronic acid-induced autophagy

Khandelwal VK, Mitrofan LM, Hyttinen JM, Chaudhari KR, Buccione R, Kaarniranta K, Ravingerová T, Mönkkönen J. PHYSIOLOGICAL RESEARCH 63 Suppl. 4: S601-S612. 2014

Silmänpohjan kostea ikärappeuma pitää hoitaa ajoissa

Kinnunen K, Kaarniranta K. SUOMEN LÄÄKÄRILEHTI 69 37: 2265-2268. 2014

Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures

Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai. EXPERIMENTAL EYE RESEARCH 120: 82-89. 2014

Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells

Kivinen Niko, Dithmer Michaela, Kinnunen Kati, Lucius Ralph, Roider Johann, Kaarniranta Kai, Klettner Alexa. Journal of Biochemical and Pharmacological Research 2 1: 44-53. 2014

Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells

Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai. Journal of biochemical and pharmacological research 2 1: 1-7. 2014

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Koskela Ali, Reinisalo Mika, Hyttinen Juha MT, Kaarniranta Kai, Karjalainen Reijo O. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 20: 760-769. 2014

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

Oksala Niku KJ, Ekmekci F Güler, Özsoy Ergi, Kirankaya Serife, Kokkola Tarja, Emecen Güzin, Lappalainen Jani, Kaarniranta Kai, Atalay Mustafa. Redox Biology 3: 25-28. 2014

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy

Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K. Clinical Ophthalmology 8: 799-805. 2014

Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells

Petrovski G, Pásztor K, Orosz L, Albert R, Mencel E, Moe MC, Kaarniranta K, Facskó A, Megyeri K. Journal of Biosciences 39 4: 683-692. 2014

A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components

Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A, Preservative-free Tafluprost/Timolol Fixed Combination Study Group Collaborators: Uusitalo H, Kaarniranta K,Saarela V, Pfeiffer N, Bartz-Schmidt U, Dunker S, Hamacher T, Heidemann K,Hofmann G, et al.. Advances in therapy 31 12: 1228-1246. 2014

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1843 12: 3038-3046. 2014

Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study

Porela-Tiihonen S, Kaarniranta K, Kokki M, Kokki H. ACTA OPHTHALMOLOGICA 93 2: e172-e173. 2014

Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

Salminen A, Kauppinen A, Kaarniranta K. Irfan Rahman and Debasis Bagchi, Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. 323-332. 2014

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. JOURNAL OF MOLECULAR MEDICINE -: -. 2014

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. CELLULAR SIGNALLING 26: 1598-1603. 2014

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. AGEING RESEARCH REVIEWS 16: 45-65. 2014

A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure

Smedowski A, Pietrucha-Dutczak M, Kaarniranta K, Lewin-Kowalik J. Scientific Reports 4: 5910; 1-11. 2014

Excipients of preservative-free latanoprost induced inflammatory response and cytotoxicity in immortalized human HCE-2 corneal epithelial cells

Smedowski Adrian, Paterno Jussi J, Toropainen Elisa,Sinha Debasish, Wylegala Edward, Kaarniranta Kai. Journal of biochemical and pharmacological research 2 4: 175-184. 2014

Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea

Smedowski Adrian, Weglarz Beata, Tarnawska Dorota, Kaarniranta Kai, Wylegala Edward. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55 2: 666-673. 2014

Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating

Sorkio Anni, Hongisto Heidi, Kaarniranta Kai, Uusitalo Hannu, Juuti-Uusitalo Kati, Skottman Heli. TISSUE ENGINEERING 20 3-4: 622-634. 2014

Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

Subrizi Astrid, Toropainen Elisa, Ramsay Eva, Airaksinen Anu J, Kaarniranta Kai, Urtti Arto. PHARMACEUTICAL RESEARCH 2015; 32: 211-221. 2014

Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration

Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14 2: 2996-3010. 2013

Potential of epigenetic mechanisms in AMD pathology

Blasiak J, Salminen A, Kaarniranta K. FRONTIERS IN BIOSCIENCE 5: 412-425. 2013

Maturation of autophagosomes and endosomes: A key role for Rab7

Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. BIOCHIMICA ET BIOPHYSICA ACTA 1833: 503-510. 2013

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. AUTOPHAGY 9 7: 1-12. 2013

Silmänpohjan kostean ikärappeuman hoito

Kaarniranta K. LÄNSI-SUOMEN TERVEYDENHOITOLEHTI 1: 20. 2013

Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling

Kauppinen A, Salminen A, Kaarniranta K. INFLAMMASOME 1: 2-14. 2013

Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. CELLULAR SIGNALLING 25: 1939-1948. 2013

Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization

Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. International Journal of Biochemistry & Cell Biology 45: 1457-1467. 2013

Retinal arterial macroaneurysms

Pitkänen L, Tommila P, Kaarniranta K, Jääskeläinen JE, Kinnunen K. ACTA OPHTHALMOLOGICA 2013: 1-4. 2013

Postoperative pain after cataract surgery

Porela-Tiihonen S, Kaarniranta K, Kokki H. JOURNAL OF CATARACT AND REFRACTIVE SURGERY 39 5: 789-98. 2013

A prospective study on postoperative pain after cataract surgery.

Porela-Tiihonen S, Kaarniranta K, Kokki M, Purhonen S, Kokki H. Clinical Ophthalmology 7: 1429-1435. 2013

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. PROGRESS IN NEUROBIOLOGY 106-107: 33-54. 2013

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen A, Kaarniranta K, Kauppinen A. AGEING RESEARCH REVIEWS 12: 520-534. 2013

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

Salminen A, Kaarniranta K, Kauppinen A. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14: 3834-3859. 2013

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS -: -. 2013

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

Tokarz P, Kaarniranta K, Blasiak J. BIOGERONTOLOGY 14 5: 461-82. 2013

Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration

Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J. Journal of Biochemical and Pharmacological Research 1 2: 106-113. 2013

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. PLOS ONE [ONLINE] 8 7: e6963, 16 pages. 2013

Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

Vottonen P, Kaarniranta K, Pääkkönen A, Tarkka IM. Clinical Ophthalmology 7: 437-442. 2013

Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration

Blasiak, J; Synowiec, E; Salminen, A; Kaarniranta, K. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13 10: 13378-13379. 2012

Efflux Protein Expression in Human Stem Cell-Derived Retinal Pigment Epithelial Cells

Juuti-Uusitalo, K; Vaajasaari, H; Ryhänen, T; Narkilahti, S; Suuronen, R; Mannermaa, E; Kaarniranta, K; Skottman, H. PLOS ONE [ONLINE] 7 1: 1-10. 2012

Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration

Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. Future Medicinal Chemistry 4 17: 2153-2161. 2012

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. NEUROSCIENCE LETTERS 513 2: 233-237. 2012

Silmänpohjan ikärappeuma yleistyy

Kaarniranta, K. OPTOMETRIA 3: 39-41. 2012

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD)

Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. IMMUNOLOGY LETTERS 147: 29-33. 2012

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration

Kinnunen, K; Petrovski, G; Moe, MC; Berta, A; Kaarniranta, K. ACTA OPHTHALMOLOGICA 90 4: 299-309. 2012

Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations

Kinnunen, PK; Kaarniranta, K; Mahalka, AK. BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES 1818 10: 2446-2455. 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, DJ, Abdalla, FC; Abeliovich, H; Abraham, RT; Acevedo-Arozena, A; Adeli, K; Agholme, L; Agnello, M; Agostinis, P; Aguirre-Ghiso, JA; Ait-Mohamed, O; Ait-Si-Ali, S; Akematsu, T; Akira, S; Al-Younes, HM; Al-Zeer, MA; Albert, ML; Albin, RL; Alegre-Abarrategui, J; Kaarniranta, K; et al.. AUTOPHAGY 8 4: 445-544. 2012

Protective function of wood-derived stilbenes against oxidative stress and inflammation in ARPE-19 cells

Mika Reinisalo, Tuomas Paimela, Tuomas Ryhänen, Anu Kauppinen, Ali Koskela, Tuula Soininen, Kai Kaarniranta, Reijo Karjalainen. Teoksessa: (toim.), XXVIth International Conference on Polyphenols, Polyphenols Communications 2012. ss. 501-502. 2012

Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice

Mykkänen OT, Kalesnykas G, Adriaens M, Evelo CT, Törrönen R, Kaarniranta K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 2338-2351. 2012

The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells

Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 1189-1196. 2012

Autophagy in the eye: a double-edged sword, (Chapter 8)

Petrovski, G; Albert, R; Kaarniranta, K; Morten, CM; Fésus, L; Berta, A; Das, DK. Ed. Gorbunov, Nikolai, Autophagy: Principles, Regulation & Roles in Disease.. 157-180. 2012

Relation of biometric eye profile with intraocular pressure corrections in healthy myopes

Pärssinen, O; Hiltunen, H; Kaarniranta, K. ACTA OPHTHALMOLOGICA 90 5: e410-412. 2012

Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process

Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. International Journal of Cell Biology 2012 ID 849541: 15 pages. 2012

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

Salminen A, Kaarniranta K. AGEING RESEARCH REVIEWS 11: 230-241. 2012

Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)

Salminen A, Kauppinen A, Kaarniranta K. CELLULAR SIGNALLING 24: 835-845. 2012

Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process

Salminen A, Kauppinen A, Kaarniranta K. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 15: 23-28. 2012

Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases

Salminen A, Ojala J, Kaarniranta K, Kauppinen A. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 69: 2999-3013. 2012

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. PROGRESS IN NEUROBIOLOGY 96: 87-95. 2012

Inflammaging: disturbed interplay between autophagy and inflammasomes

Salminen, A; Kaarniranta, K; Kauppinen, A. AGING 4 3: 166-175. 2012

Aikuisten alakyyneltietukosten kirurginen hoito

Seppä J, Smirnov G, Kaarniranta K, Tuomilehto H. DUODECIM 128 2: 205-2011. 2012

Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies

Szalai, E; Felszeghy, S; Hegyi, Z; Módis, L Jr; Berta, A; Kaarniranta, K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 18: 1927-1936. 2012

Increased IL-6 levels are not related to NF-kappaB or HIF-1alfa: transcription factors activity in the vitreous of proliferative diabetic retinopathy

Arjamaa O, Pöllönen M, Kinnunen K, Ryhänen T, Kaarniranta K. 2011. Increased IL-6 levels are not related to NF-kappaB or HIF-1alfa; transcription factors activity in the vitreous of proliferative diabetic retinopathy JOURNAL OF DIABETES AND ITS COMPLICATIONS 25 6: 393-397. 2011

5'-adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration

Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. REJUVENATION RESEARCH 14 6: 651-660. 2011

Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro

Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 17: 2311-2317. 2011

Age-related macular degeneration (AMD): Alzheimer's Disease in the eye

Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Journal of Alzheimer's Disease 24: 615-631. 2011

Silmänpohjan ikärappeuman hoidossa halvempi on tehokas ja turvallinen

Kaarniranta K. SUOMEN LÄÄKÄRILEHTI 22: 1812. 2011

Ravistellun lapsen oireyhtymään liittyvät silmälöydökset

Nevalainen T, Kaarniranta K, Puustjärvi T, Kontkanen M. SUOMEN LÄÄKÄRILEHTI 66 6: 453-455. 2011

Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells

Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. PHARMACOLOGICAL RESEARCH 64: 501-508. 2011

Mitomycin C in revision endoscopic dacryocystorhinostomy: A prospective randomized study

Penttilä E, Smirnov G, Seppä J, Kaarniranta K, Tuomilehto H. American Journal of Rhinology & Allergy 25 6: 425-428. 2011

AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan

Salminen A, Hyttinen JMT, Kaarniranta K. JOURNAL OF MOLECULAR MEDICINE 89: 667-676. 2011

Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. PROGRESS IN NEUROBIOLOGY 96: 87-95. 2011

AMP-activated protein kinase: a potential player in Alzheimer's disease

Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. JOURNAL OF NEUROCHEMISTRY 118: 460-474. 2011

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 34: 3-11. 2011

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

Salminen A, Ojala J, Kaarniranta K. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 68: 1021-1031. 2011

Control of p53 and NF-kB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

Salminen Antero, Kaarniranta Kai. CELLULAR SIGNALLING 23: 747-752. 2011

Plant flavonol quercetin and isoflavone biochanin-A differentially induce protection against oxidative stress and inflammation in ARPE-cells

Saviranta Niina, Veeroos Laura, Granlund Lars, Hassinen Viivi, Kaarniranta Kai, Karjalainen Reijo. FOOD RESEARCH INTERNATIONAL 44: 109-113. 2011

Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats

Seppo Rönkkö, Kai Kaarniranta, Giedrius Kalesnykas, Hannu Uusitalo. OPHTHALMIC RESEARCH 46: 55-65. 2011

Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study

Smirnov G, Pirinen R, Tuomilehto H, Seppä J, Teräsvirta M, Uusitalo H, Nuutinen J, Kaarniranta K. ACTA OPHTHALMOLOGICA 89 2: e132-e136. 2011

Autophagy - hot topic in AMD

Kaarniranta K. ACTA OPHTHALMOLOGICA 88: 387-388. 2010

Regression of necrotizing scleritis in Wegener's granulomatosis after infiximab treatment

Kaarniranta K. ACTA OPHTHALMOLOGICA 88 3: e96-97. 2010

Mechanisms of protein aggregation in the retinal pigment epithelial cells

Kai Kaarniranta, Juha Hyttinen, Tuomas Ryhanen, Johanna Viiri, Tuomas Paimela, Elisa Toropainen, Iiris Sorri & Antero Salminen. FRONTIERS IN BIOSCIENCE E2: 1374-1384. 2010

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

Mannermaa E, Reinisalo M, Ranta V-P, Vellonen K-S, Kokki H, Saarikko A, Kaarniranta K & Urtti A. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 40: 289-296. 2010

Altered calcium signaling in a experimental model of glaucoma

Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Åkerman KEO, Uusitalo H. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 51 12: 6387-6393. 2010

Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)

Paimela T, Hyttinen JMT, Viiri J, Ryhänen T, Karvonen MK, Unkila M, Uusitalo H, Salminen A & Kaarniranta K. EUROPEAN JOURNAL OF PHARMACOLOGY 640: 219-225. 2010

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells

Ryhänen T, Viiri J, Hyttinen JTM, Uusitalo H, Salminen A & Kaarniranta K. Journal of biomedicine and biotechnology 2011;2011;798052. Epub 2010 Oct 24: 1-8. 2010

ER stress and hormetic regulation of the aging process

Salminen A & Kaarniranta K. AGEING RESEARCH REVIEWS 9: 211-217. 2010

Genetics vs. entrophy: Longevity factors suppress the NF-kB-driven entropic aging process

Salminen A & Kaarniranta K. AGEING RESEARCH REVIEWS 9: 298-314. 2010

Glycolysis Links p53 Function With NF-kB Signaling: Impact on Cancer and Aging Process

Salminen A & Kaarniranta K. JOURNAL OF CELLULAR PHYSIOLOGY 224: 1-6. 2010

Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-kB signaling

Salminen A & Kaarniranta K. CELLULAR SIGNALLING 22: 573-577. 2010

Endoplasmic reticulum stress in age-related macular degeneration: Trigger for neovascularization

Salminen A, Kauppinen A, Hyttinen JMT, Toropainen E & Kaarniranta K. MOLECULAR MEDICINE TODAY 16 11-12: 535-542. 2010

Celastrol: Molecular targets of Thunder God Vine

Salminen A, Lehtonen M, Paimela T & Kaarniranta K. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394: 439 - 442. 2010

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. PROGRESS IN NEUROBIOLOGY 93: 99-110. 2010

Symptom score questionnaire for nasolacrimal duct obstruction in adults - a novel tool to assess the outcome after endoscopic dacryocystorhinostomy

Smirnov G, Tuomilehto H, Kokki H, Kemppainen T, Kiviniemi V, Nuutinen J, Kaarniranta K & Seppä J. RHINOLOGY 48: 446-451. 2010

Switching from a preserved toa preservative-free prostaglandin preparation in topical glaucoma medication

Uusitalo H, Chen E, Pfeiffer N, Brignole-Baudouin F, Kaarniranta K, Leino M, Puska P, Palmgren E, Hamacher T, Hofmann G, Petzold G, Richter U, Riedel T, Winter M & Ropo A. ACTA OPHTHALMOLOGICA 88: 329-336. 2010

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells

Viiri J, Hyttinen JMT, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A & Kaarniranta K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 16: 1399-1414. 2010

Regulatory role of HIF-1alfa in the pathogenesis of age-related macular degeneration (AMD)

Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. AGEING RESEARCH REVIEWS 8: 349-358. 2009

Silmänpohjan ikärappeuman riskitekijät ja hoito

Kaarniranta K, Puustjärvi T, Sorri I. TERVEYDENHOITOVIESTI, KESKI-SUOMI PIRKANMAA 1: s. 16, 29. 2009

Heat shock proteins as gatekeepers of proteolytic pathways - Implications for age-related macular generation (AMD)

Kaarniranta K, Salminen A, Eskelinen E-L, Kopitz J. AGEING RESEARCH REVIEWS 8: 128-139. 2009

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

Kaarniranta K, Salminen A. JOURNAL OF MOLECULAR MEDICINE 87: 117-123. 2009

NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)

Kaarniranta K, Salminen A. EXPERIMENTAL GERONTOLOGY 44: 685-688. 2009

Silmänpohjan ikärappeuman patogeneesi

Kaarniranta K, Seitsonen S, Paimela T, Meri S, Immonen I. DUODECIM 125: 145-153. 2009

Vääristyvä kuva silmänpohjan ikärappeumassa - kuinka hoidetaan?

Kaarniranta K. SUOMEN LÄÄKÄRILEHTI 64 44: 3759-3763. 2009

Retinal haemorrhages in shaken baby syndrome

Kontkanen M, Kaarniranta K. ACTA OPHTHALMOLOGICA 87 4: 471-473. 2009

Efflux protein expression in human retinal pigment epithelium cell lines

Mannermaa E, Vellonen K-S, Ryhänen T, Kokkonen K, Ranta V-P, Kaarniranta K, Urtti A. PHARMACEUTICAL RESEARCH 26 7: 1785-1791. 2009

NF-kappaB signaling in the aging process

Salminen A, Kaarniranta K. JOURNAL OF CLINICAL IMMUNOLOGY 29: 397-405. 2009

Regulation of the aging process by autophagy

Salminen A, Kaarniranta K. TRENDS IN MOLECULAR MEDICINE 15 5: 217-224. 2009

Siglec receptors and hiding plaques in Alzheimer's disease

Salminen A, Kaarniranta K. JOURNAL OF MOLECULAR MEDICINE 87: 697-701. 2009

SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree

Salminen A, Kaarniranta K. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 378: 6-9. 2009

SIRT1: Regulation of longevity via autophagy

Salminen A, Kaarniranta K. CELLULAR SIGNALLING 21: 1356-1360. 2009

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 6 41: [13 p.]. 2009

Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. PROGRESS IN NEUROBIOLOGY 87: 181-194. 2009

Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration

Tolppanen A-M, Nevalainen T, Kolehmainen M, Seitsonen S, Immonen I, Uusitupa M, Kaarniranta K, Pulkkinen L, Tolppanen A-M, Kolehmainen M, Uusitupa M, Pulkkinen L. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 15: 762-770. 2009

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro

Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 15: 1799-1805. 2009

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies

Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE 19: 645-649. 2008

Diabeteksen aiheuttamat silmämuutokset

Kaarniranta K, Sorri I. SUOMEN LÄÄKÄRILEHTI 63 7: 621-624. 2008

Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells

Ryhänen T, Mannermaa E, Oksala N, Viiri J, Paimela T, Salminen A, Atalay M, Kaarniranta K. EUROPEAN JOURNAL OF PHARMACOLOGY 584: 229-236. 2008

Histopathology of the three implanted degradable biopolymers in rabbit eye

Rönkkö S, Rekonen P, Sihvola R, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 88 3: 717-724. 2008

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. AGEING RESEARCH REVIEWS 7: 83-105. 2008

SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. BIOESSAYS 30: 939-942. 2008

Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential

Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 65: 2979-2999. 2008

Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1

Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 65: 1049-1058. 2008

Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology

Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12 6A: 2255-2262. 2008

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

Salminen A, Paimela T, Suuronen T, Kaarniranta K. IMMUNOLOGY LETTERS 117: 9-15. 2008

NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?

Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 367: 715-718. 2008

ROCK, PAK, and Toll of synapses in Alzheimer's disease

Salminen A, Suuronen T, Kaarniranta K. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371: 587-590. 2008

Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration

Seitsonen SP, Onkamo P, Peng G, Xiong M, Tommila PV, Ranta PH, Holopainen JM, Moilanen JA, Palosaari T, Kaarniranta K, Meri S, Immonen IR, Järvelä IE. PLOS ONE [ONLINE] 3 12: e3833. 2008

Regulation of ERalfa signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90

Suuronen T, Ojala J, Hyttinen JMT, Kaarniranta K, Thornell A, Kyrylenko S, Salminen A. NEUROCHEMICAL RESEARCH 33: 1768-1775. 2008

Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers

Uusitalo H, Kaarniranta K, Ropo A. ACTA OPHTHALMOLOGICA. SUPPLEMENT 86 S242: 7-13. 2008

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues:Direct contact studies

Huhtala A, Pohjonen T, Salminen L, Salminen A, Kaarniranta K, Uusitalo H. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A 83A 2: 407-413. 2007

Leucine 7-proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration

Kaarniranta K, Holopainen JM , Karvonen MK, Koulu M, Kallio J, Pesonen U, Teräsvirta M, Uusitalo H, Immonen I. ACTA OPHTHALMOLOGICA 85: 188-191. 2007

Maculopathy in Pierre Robin sequences

Kaarniranta K, Tuppurainen K, Nikolajev K. JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS 44 1: 10-11. 2007

The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model

Kalesnykas G, Niittykoski M, Rantala J, Miettinen R, Salminen A, Kaarniranta K, Uusitalo H. NEUROSCIENCE 150: 692-704. 2007

Imiquimod in the treatment of eyelid basal cell carcinoma

Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M. ACTA OPHTHALMOLOGICA 85: 566-568. 2007

Silmänpohjan nesteisen ikärappeuman uudet lääkkeet

Mannermaa E, Urtti A, Kaarniranta K. DUODECIM 123: 2229-2237. 2007

Alpha-lipoic acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney

Oksala NKJ, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. ANTIOXIDANTS AND REDOX SIGNALING 9 4: 497-506. 2007

The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells

Paimela T, Ryhänen T, Mannermaa E, Ojala J, Kalesnykas G, Salminen A, Kaarniranta K, Ojala J. IMMUNOLOGY LETTERS 110: 139-144. 2007

Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma

Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 13: 408-417. 2007

Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma

Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo M. GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 245: 697-704. 2007

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

Suuronen T, Nuutinen T, Ryhänen T, Kaarniranta K, Salminen A. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357: 397-401. 2007

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

Toropainen E, Hornof M, Kaarniranta K, Johansson P, Urtti A. JOURNAL OF GENE MEDICINE 9: 208-216. 2007

A mouse model for Stickler's syndrome: Ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2al)

Kaarniranta K, Ihanamäki T, Sahlman J, Pulkkinen H, Uusitalo H, Arita M, Tammi R, Lammi MJ, Helminen H. EXPERIMENTAL EYE RESEARCH 83: 297-303. 2006

Immunolocalization of EMMPRIN (Cd147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids

Määttä M, Tervahartiala T, Kaarniranta K, Tang Y, Yan L, Tuukkanen J, Sorsa T. CURRENT EYE RESEARCH 31 11: 917-924. 2006

Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population

Seitsonen S, Lemmelä S, Holopainen J, Tommila P, Ranta P, Kotamies A, Moilanen J, Palosaari T, Kaarniranta K, Meri S, Immonen I, Järvelä I. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 12: 796-801. 2006

Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure

Elo MA, Kaarniranta K, Helminen HJ, Lammi MJ. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1743 1-2: 115-119. 2005

Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells

Kaarniranta K, Ryhänen T, Karjalainen HM, Lammi MJ, Suuronen T, Huhtala A, Kontkanen M, Teräsvirta M, Uusitalo H, Salminen A. NEUROSCIENCE LETTERS 382: 185-190. 2005

Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells

Kaarniranta K, Ryhänen T, Sironen RK, Suuronen T, Elo MA, Karjalainen HM, Lammi MJ, Teräsvirta M, Uusitalo H, Salminen A. MOLECULAR BRAIN RESEARCH 137: 126-131. 2005

Solustressi yhdistyy silmänpohjan ikärappeumaan

Kaarniranta K. SILMÄHOITAJA 2: 4-5. 2005

Hydrostatic pressure-induced changes in cellular protein syntheisis

Lammi MJ, Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ. BIORHEOLOGY 41: 309-313. 2004

Specific induction of heat shock protein 90 beta by high hydrostatic pressure

Elo MA, Sironen RK, Karjalainen HM, Kaarniranta K, Helminen HJ, Lammi MJ. BIORHEOLOGY 40 1-3: 141-146. 2003

Stress responses of mammalian cells to high hydrostatic pressure

Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. BIORHEOLOGY 40 1-3: 87-92. 2003

Silmänpohjan ikärappeuma - vaikea ongelma sekä potilaalle että silmälääkärille

Kaarniranta K, Sihvola R, Salminen A, Lammi MJ, Teräsvirta M, Kontkanen M. DUODECIM 119: 935-942. 2003

Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study

Karjalainen HM, Sironen RK, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. BIORHEOLOGY 40 1-3: 93-100. 2003

Neuronal cells show regulatory differences in the hsp70 gene response

Kaarniranta K, Oksala N, Karjalainen HM, Suuronen T, Sistonen L, Helminen HJ, Salminen A, Lammi MJ. MOLECULAR BRAIN RESEARCH 101: 136-140. 2002

Regulatory Differences of the hsp70 Gene Response in Mammalian Cells

Kaarniranta K. Kuopion yliopiston julkaisuja D. Lääketiede. 2002

cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure

Sironen RK, Karjalainen HM, Elo MA, Kaarniranta K, Törrönen K, Takigawa M, Helminen HJ, Lammi MJ. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1591: 45-54. 2002

High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis

Sironen RK, Karjalainen HM, Törrönen K, Elo MA, Kaarniranta K, Takigawa M, Helminen HJ, Lammi MJ. BIORHEOLOGY 39 1,2: 111-117. 2002

Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway

Törrönen K, Yabal M, Rilla K, Kaarniranta K, Tammi R, Lammi MJ, Tammi M. Teoksessa: Kennedy JF, Phillips GO, Williams PA, Hascall VC (toim.), Hyaluronan. Chemical, Biochemical and Biological Aspects..Woodhead. ss. 551-556. 2002

Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response

Kaarniranta K, Holmberg CI, Lammi MJ, Eriksson JE, Sistonen L, Helminen HJ. OSTEOARTHRITIS AND CARTILAGE 9 1: 7-13. 2001

Solustressin tutkimuksesta kliinisiin läpimurtoihin?

Kaarniranta K, Oksala N, Lammi MJ, Helminen HJ, Sistonen L. DUODECIM 117: 2266-2272. 2001

Responses of mammalian cells to mechanical forces

Lammi MJ, Sironen RK, Elo MA, Oksala N, Kaarniranta K, Karjalainen HM, Helminen HJ. Pandalai SG, Recent Research Developments in Biophysics and Biochemistry.Research Signpost. 77-98. 2001

Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells

Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. JOURNAL OF CELLULAR BIOCHEMISTRY 79: 610-619. 2000

Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature

Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. FEBS LETTERS 475: 283-286. 2000

Transcriptional activation in chondrocytes submitted to hydrostatic pressure

Sironen R, Elo M, Kaarniranta K, Helminen HJ, Lammi MJ. BIORHEOLOGY 37: 85-93. 2000

Cytoskeleton and proteoglycan synthesis in chondrocytes under hydrostatic pressure

Parkkinen JJ, Lammi MJ, Jortikka MO, Inkinen RI, Kaarniranta K, Helminen HJ, Tammi MI. Tanaka S, Hamanishi C, Advances in Osteoarthritis.Springer. 21-34. 1999

Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium

Alastalo T-P, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. EXPERIMENTAL CELL RESEARCH 240: 16-27. 1998

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

Kaarniranta K, Elo M, Sironen R, Lammi MJ, Goldring MB, Eriksson JE, Sistonen L, Helminen HJ. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95: 2319-2324. 1998

Tutkimusryhmät

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells

Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells

Potential of Telomerase in Age-Related Macular Degeneration-Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α

Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice

Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Incidence of cataract surgeries in people with and without Alzheimer's disease

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration

MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy

Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) - the involvement of mitochondrial quality control, autophagy, and antioxidant response

Successful years of collaboration between Acta Ophthalmologica and the European Association for Vision and Eye Research

The most successful year in the history of Acta Ophthalmologica

The state of your journal Acta Ophthalmologica 2020

Effect of cataract surgery on wet age-related macular degeneration activity

Lasiaisinjektiot mullistivat silmänpohjan kostean ikärappeuman hoidon

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3

Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization

Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation

Immunological biomarkers of the vitreous responsible for proliferative alteration in the different forms of retinal detachment

Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells

Zinc and Autophagy in Age-Related Macular Degeneration

The Aging Stress Response and Its Implication for AMD Pathogenesis

Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery

In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby Fundus Dystrophy

Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells

DICER1 in the Pathogenesis of Age-related Macular Degeneration (AMD) - Alu RNA Accumulation versus miRNA Dysregulation

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

Correlation Between the Rate of Intravitreal Injections, Use of Aflibercept as a Second-Line Treatment and Visual Impairment for Wet AMD in Finland

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted

Trehalose for Ocular Surface Health

Yhtenäiset vaatimukset lääketieteen ja hammaslääketieteen tohtorintutkinnolle Suomessa

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study

ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease

Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process

Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model

Comparison of Two Different Treat-and-Extend Protocols with Afibercept in Wet Age-Related Macular Degeneration: Two-Year Results

The role of vision-related problems in fatal road accidents in Finland

Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study

Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration

Expression of VEGFA-regulating miRNAs and mortality in wet AMD

Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology

Can vitamin D protect against age-related macular degeneration or slow its progression?

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD).

Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration

Real Life Experience of Dexamethasone Implant in Refractory Diabetic Macular Oedema

Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells

Disease aetiology-based design of multifunctional microemulsion eye drops for moderate or severe dry eye: a randomized, quadruple-masked and active-controlled clinical trial

Dietary Polyphenols in Age-Related Macular Degeneration: Protection against Oxidative Stress and Beyond

Resvega alleviates oxidative stress and inflammasome activation in retinal pigment epithelial cells

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

Electrical synapses interconnecting axons revealed in the optic nerve head - a novel model of gap junctions' involvement in optic nerve function

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

The first ophthalmic Choosing Wisely recommendations in Finland for glaucoma and wet age-related macular degeneration

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Molecular Mechanisms Underlying Age-Related Ocular Diseases

Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Mitochondrial quality control in AMD: does mitophagy play a pivotal role?

Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits

Bestin tauti

Fluoreseiiniangiografia (FAG)

Fotodynaaminen hoito (PDT)

Mikrobinäytteen otto silmästä

Optinen valokerroskuvaus (OCT)

Silmänpohjan ikärappeumat