KATJA KANNINEN
Akatemiatutkija
Johdan 'Neurobiology of Disease' -tutkimusryhmää A.I.Virtanen -instituutissa, jossa toimin apulaisprofessorina. Tutkimme ympäristön vaikutuksia aivoterveyteen ja Alzheimerin tautiin. Käytämme tutkimuksessa potilasperäisiä solumalleja.
Lisätietoa tutkimusryhmästä osoitteessa: https://uefconnect.uef.fi/en/group/neurobiology-of-disease/
Yhteystiedot
Organisaatio
Terveystieteiden tiedekunta, A. I. Virtanen -instituutti
Avainsanat
aivoterveys
Alzheimerin tauti
astrosyytit
biomarkkerit
elintavat
gliasolut
hajuepiteelisolut
ilmansaasteet
sairauden neurobiologia
ympäristötekijät
Julkaisut
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Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al; incl. Kanninen, K; Leinonen, V. 2020. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy Alzheimer's & dementia 21 1: e12053. 2020
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Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR. 2020. Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration Neurochemistry international 136: 104729. 2020
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Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. 2020. Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation Journal of neuroinflammation 17: 194. 2020
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Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM. 2020. Impairment of mitochondrial function by particulate matter: Implications for the brain Neurochemistry international 135: 104694. 2020
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Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja. 2020. Glial smog: Interplay between air pollution and astrocyte-microglia interactions Neurochemistry international 136: 104715. 2020
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Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M. 2020. Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells Particle and fibre toxicology 17 1: 18. 2020
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Doccini, S; Morani, F; Nesti, C; Pezzini, F; Calza, G; Soliymani, R; Signore, G; Rocchiccioli, S; Kanninen, KM; Huuskonen, MT; Baumann, MH; Simonati, A; Lalowski, MM; Santorelli, FM. 2020. Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction Cell death discovery 6 1: 18. 2020
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Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al.. 2019. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia Stem cell reports 13 4: 669-683. 2019
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Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, Š; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T. 2019. Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis IBRO Reports 6: 74-86. 2019
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Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, Š; Kanninen, KM; Hämäläinen, RH; Koistinaho, J. 2019. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes Glia 2020; 68 3: 589-599. 2019