Leea Keski-Nisula

Hiltunen, Janika; Eloranta, Marja-Liisa; Lindgren, Auni; Keski-Nisula, Leea; Anttila, Maarit; Sallinen, Hanna. 2021. Robotic-assisted laparoscopy is a feasible method for resection of deep infiltrating endometriosis, especially in the rectosigmoid area Journal of international medical research 49 8: 1-12. 2021

Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Romppanen, Jarkko; Keski-Nisula, Leea; Heinonen, Seppo; Laitinen, Tomi. 2021. Endothelial function and concentrations of high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha during a long agonist IVF protocol Journal of reproductive immunology 148: 103434. 2021

Rajala, K.; Mönkkönen, A.; Saarelainen, H.; Keski-Nisula, L.. 2021. Fetal lactate levels align with the stage of labour European journal of obstetrics and gynecology and reproductive biology 261: 139-143. 2021

Ruohomäki, Aleksi; Toffol, Elena; Airaksinen, Ville; Backman, Katri; Voutilainen, Raimo; Hantunen, Sari; Tuomainen, Tomi-Pekka; Lampi, Jussi; Kokki, Hannu; Luoma, Ilona; Kumpulainen, Kirsti; Heinonen, Seppo; Keski-Nisula, Leea; Pekkanen, Juha; Pasanen, Markku; Lehto, Soili M.. 2021. The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study Journal of psychiatric research 136: 388-397. 2021

von Hellens, Hetti; Keski-Nisula, Leea; Sahlman, Heidi. 2021. Increased risk of preeclampsia after use of paracetamol during pregnancy - causal or coincidence? Bmc pregnancy and childbirth 21 1: 24. 2021

Karvonen, AM; Lampi, J; Keski-Nisula, L; Auvinen, J; Toppila, Salmi, S; Järvelin, MR; Pekkanen, J. 2021. Farm environment during pregnancy and childhood and polysensitization at the age of 31 - Prospective birth cohort study in Finland Journal of investigational allergology and clinical immunology 31 1: 44-51. 2021

Kerttula, Salla; Keski-Nisula, Leea; Kuivasaari-Pirinen, Paula. 2020. Lapsettomuushoidon ensikäynnistä kaksi vuotta. Yli puolelle hoidetuista lapsi Lääkärilehti 75 23: 1441-1446. 2020

Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. Caffeine content in newborn hair correlates with maternal dietary intake European journal of nutrition 2021; 60: 193-201. 2020

Leppänen, Jonna; Randell, Kaisa; Schwab, Ursula; Pihlajamäki, Jussi; Keski-Nisula, Leea; Laitinen, Tomi; Heinonen, Seppo. 2020. The effect of different estradiol levels on carotid artery distensibility during a long agonist IVF protocol Reproductive biology and endocrinology 18 1: 44. 2020

Lintula, Aino; Keski-Nisula, Leea; Sahlman, Heidi. 2020. Hypothyroidism and the increased risk of preeclampsia - interpretative factors? Hypertension in pregnancy 39 4: 411-417. 2020

Sopo, Minna; Anttila, Maarit; Muukkonen, Oona-Tuuli; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Sallinen, Hanna. 2020. Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors Anticancer research 40 12: 6923-6931. 2020

Sopo, Minna; Sallinen, Hanna; Hämäläinen, Kirsi; Kivelä, Annukka; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Anttila, Maarit. 2020. High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer PLoS ONE 15 11: e0241484. 2020

Soininen, Jenni; Keski-Nisula, Leea. 2019. Kunnankätilö Makkosen hoitamat kotisynnytykset Pohjois-Savossa vuonna 1958 Duodecim 135 24: 2437-2345. 2019

Virusinfektiot. Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea / Naistentaudit ja synnytykset. 2019. 2019

Sopo, M; Anttila, M; Hämäläinen, K; Kivelä, A; Ylä-Herttuala, S; Kosma, VM; Keski-Nisula, L; Sallinen, H. 2019. Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer Bmc cancer 19: 584. 2019

Zoonoosit. Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea / Naistentaudit ja synnytykset. 2019. 2019

Sahlman, H; Koponen, M; El-Nezami, H; Vahakangas, K; Keski-Nisula, L. 2019. Maternal use of drugs and preeclampsia British journal of clinical pharmacology 85 12: 2848-2855. 2019

Raskaudenaikaiset infektiot. Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea / Naistentaudit ja synnytykset. 2019. 2019

Dekel, S; Ein-Dor, T; Ruohomäki, A; Lampi, J; Voutilainen, S; Tuomainen, TP; Heinonen, S; Kumpulainen, K; Pekkanen, J; Keski-Nisula, L; Pasanen, M; Lehto, SM. 2019. The dynamic course of peripartum depression across pregnancy and childbirth Journal of psychiatric research 113: 72-78. 2019

Bakteeri-infektiot. Aitokallio-Tallberg, Ansa; Keski-Nisula, Leea / Naistentaudit ja synnytykset. 2019. 2019

Harju, Maijakaisa; Pekkanen, Juha; Heinonen, Seppo; Keski-Nisula, Leea. 2018. Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring Journal of obstetrics and gynaecology research 44 4: 614-622. 2018

Huuskonen, P; Keski-Nisula, L; Heinonen, S; Voutilainen, S; Tuomainen, TP; Pekkanen, J; Lampi, J; Lehto, SM; Haaparanta, H; Elomaa, AP; Voutilainen, R; Backman, K; Kokki, H; Kumpulainen, K; Paananen, J; Vähäkangas, K; Pasanen, M. 2018. Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child BMC PREGNANCY AND CHILDBIRTH 18: 381. 2018

Ruohomäki, Aleksi; Toffol, Elena; Upadhyaya, Subina; Keski-Nisula, Leea; Pekkanen, Juha; Lampi, Jussi; Voutilainen, Sari; Tuomainen, Tomi-Pekka; Heinonen, Seppo; Kumpulainen, Kirsti; Pasanen, Markku; Lehto, Soili M. 2018. The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study Journal of affective disorders 241: 263-268. 2018

Vuokko, Aki; Karvala, Kirsi; Lampi, Jussi; Keski-Nisula, Leea; Pasanen, Markku; Voutilainen, Raimo; Pekkanen, Juha; Sainio, Markku. 2018. Environmental Intolerance, Symptoms and Disability Among Fertile-Aged Women. International Journal of Environmental Research and Public Health 15 2: 293. 2018

Martikainen M-V, Keski-Nisula L, Jakupovic H, Karvonen AM, Pekkanen J, Hirvonen M-R, Roponen M. 2017. The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (NEW YORK) 77 3: -. 2017

Sokka Arja, Olsen Päivi, Kirjavainen Jarkko, Harju Maijakaisa, Keski-Nisula Leea, Räisänen Sari, Heinonen Seppo, Kälviäinen Reetta. 2017. Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study. Epilepsia Open 2 1: 76-83. 2017

Huuskonen Pasi, Amezaga Maria R, Bellingham Michelle, Jones Lucy H, Storvik Markus, Häkkinen Merja, Keski-Nisula Leea, Heinonen Seppo, O'Shaughnessy Peter J, Fowler Paul A, Pasanen Markku. 2016. The human placental proteome is affected by maternal smoking. REPRODUCTIVE TOXICOLOGY 63: 22-31. 2016

Harju Maijakaisa, Keski-Nisula Leea, Georgiadis Leena, Heinonen Seppo. 2016. Parental smoking and cessation during pregnancy and the risk of childhood asthma. BMC PUBLIC HEALTH 16 248: 1-7. 2016

Bergroth E, Roponen M, Karvonen AM, Keski-Nisula L, Remes S, Riedler J, Roduit C, Dalphin J-C, Kaulek V, Loss GJ, Lauener R, Hirvonen M-R, Genuneit J, Schmaußer-Hechfellner E, Renz H, Pfefferle PI, Krauss-Etschmann S, Schaub B, von Mutius E, Pekkanen J, the PASTURE study group. 2016. Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy PEDIATRIC ALLERGY AND IMMUNOLOGY 2017; 28 1: 53-59. 2016

Harju Maijakaisa, Keski-Nisula Leea, Georgiadis Leena, Raatikainen Kaisa, Räisänen Sari, Heinonen Seppo. 2015. Maternal socioeconomic status and the risk of asthma among offspring. BMC PUBLIC HEALTH 15: 27. 2015

Georgiadis L, Keski-Nisula L, Harju M, Räisänen S, Georgiadis S, Hannila ML, Heinonen S. 2014. Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study. PLACENTA (LONDON) 35 4: 275-280. 2014

Karvonen AM, Hyvärinen A, Rintala H, Korppi M, Täubel M, Doekes G, Gehring U, Renz H, Pfefferle PI, Genuneit J, Keski-Nisula L, Remes S, Lampi J, von Mutius E, Pekkanen J. 2014. Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study. ALLERGY 69 8: 1092-1101. 2014

Harju M, Keski-Nisula L, Georgiadis L, Räisänen S, Gissler M, Heinonen S. 2013. The Burden of Childhood Asthma and Late Preterm and Early Term Births. JOURNAL OF PEDIATRICS [Epub ahead of print]: 1-6. 2013

Keski-Nisula L, Kyynäräinen HR, Kärkkäinen U, Karhukorpi J, Heinonen S, Pekkanen J. 2013. Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth. ACTA PAEDIATRICA 102 5: 480-485. 2013

Mustonen K, Orivuori L, Keski-Nisula L, Hyvärinen A, Pfefferle PI, Riedler J, Dalphin JC, Genuneit J, Lauener R, Roduit C, Braun-Fahrländer C, Weber J, Schaub B, von Mutius E, Pekkanen J, Vaarala O; PASTURE Study Group.. 2013. Inflammatory response and IgE sensitization at early age. PEDIATRIC ALLERGY AND IMMUNOLOGY 24 4: 395-401. 2013

Räisänen S, Georgiadis L, Harju M, Keski-Nisula L, Heinonen S. 2013. True umbilical cord knot and obstetric outcome. INTERNATIONAL JOURNAL OF GYNAECOLOGY & OBSTETRICS 122 1: 18-21. 2013

Räisänen S, Sokka A, Georgiadis L, Harju M, Gissler M, Keski-Nisula L, Kälviäinen R, Heinonen S. 2013. Infertility treatment and umbilical cord length-novel markers of childhood epilepsy?. PLOS ONE [ONLINE] 8 2: e55394. 2013

Räisänen, S; Georgiadis, L; Harju, M; Keski-Nisula, L; Heinonen, S. 2012. Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 2012: 1-4. 2012

Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin J-C, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J, the PASTURE Study Group. 2012. Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas. CLINICAL AND EXPERIMENTAL ALLERGY 42 8: 1246-1256. 2012

Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin JC, Buechele G, Lauener R, Braun-Fahrländer C, von Mutius E, Pekkanen J, the PASTURE Study Group, 19 jäsentä; Remes S. 2012. Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children. PEDIATRIC ALLERGY AND IMMUNOLOGY 23 6: 522-528. 2012

Bergroth, E; Remes, S; Pekkanen, J; Kauppila, T; Büchele, G; Keski-Nisula, L. 2012. Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. PEDIATRICS 130 2: 211-220. 2012

Keski-Nisula L, Heiskanen P, Heinonen S. 2011. Extra-membranous pregnancy, prolonged ruptured membranes and circumvallate placenta ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 90 10: 1170-1171. 2011

Lampi J, Canoy D, Jarvis D, Hartikainen AL, Keski-Nisula L, Järvelin MR, Pekkanen J. 2011. Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland CLINICAL AND EXPERIMENTAL ALLERGY 41: 987-993. 2011

Keski-Nisula L, Lappalainen MHJ, Mustonen K, Hirvonen M-R, Pfefferle PI, Renz H, Pekkanen J & Roponen M. 2010. Production of interleukin-5, -10 and interferon-g in cord blood is strongly associated with the season of birth. CLINICAL AND EXPERIMENTAL ALLERGY 40: 1658-1668. 2010

L Keski-Nisula, A Karvonen, PI Pfefferle, H Renz, G Büchele & J Pekkanen. 2010. Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhood. ALLERGY 65: 1116-1125. 2010

Leea Keski-Nisula, Maija Jääskeläinen & Seppo Saarikoski. 2010. Veri kiersi pullapitkon kautta. DUODECIM 126 2: 195. 2010

Keski-Nisula L, Katila M-L, Remes S, Heinonen S, Pekkanen J. 2009. Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 123: 1305-1311. 2009

Keski-Nisula L, Heinonen S, Remes S, Pekkanen J. 2009. Pre-eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (NEW YORK) 62: 293-300. 2009

Keski-Nisula L, Harju M, Järvelin M-R, Pekkanen J. 2009. Vacuum-assisted delivery is associated with late-onset asthma. ALLERGY 64: 1530-1538. 2009

Jaaskelainen E, Keski-Nisula L, Toivonen S, Paattiniemi E-L, Helisalmi S, Punnonen K, Heinonen S. 2008. Polymorphism of the interleukin 1 receptor antatgonist (IL1Ra) gene and placental abruption. JOURNAL OF REPRODUCTIVE IMMUNOLOGY 79: 58-62. 2008

Jääskeläinen E, Toivonen S, Keski-Nisula L, Paattiniemi E-L, Helisalmi S, Punnonen K, Heinonen S. 2008. CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 46 2: 169-173. 2008

Keski-Nisula L. 2008. Raskausajan diabetes yleistyy: liikaa energiaa, liian vähän liikuntaa ja insuliinia. ERIKOISLÄÄKÄRI 18 1: 45-48. 2008

Keski-Nisula L, Järvelin MR, Pekkanen J. 2007. No association between placental weight or ratio at birth and risk of atopy, hay fever, or asthma at the age of 31 years JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (BARCELONA) 17 6: 416-417. 2007

Papinniemi M, Keski-Nisula L, Heinonen S. 2007. Placental ratio and risk of velamentous umbilical cord insertion are increased in women with placenta praevia. AMERICAN JOURNAL OF PERINATOLOGY 24: 353-358. 2007

Jääskeläinen E, Keski-Nisula L, Toivonen S, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S, Helisalmi S. 2006. MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in finnish women. HYPERTENSION IN PREGNANCY 25: 73-80. 2006

Keski-Nisula L, Pekkanen J, Xu B, Putus T, Koskela P. 2006. Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring. ALLERGY 61: 1467-1472. 2006

Toivonen S, Keski-Nisula L, Romppanen E-L, Helisalmi S, Punnonen K, Heinonen S. 2005. Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in finnish women. FETAL DIAGNOSIS AND THERAPY 20: 508-511. 2005

Heikkilä A, Tuomisto T, Häkkinen S-K, Keski-Nisula L, Heinonen S, Ylä-Herttuala S. 2005. Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - an array study on casespecific human preeclamptic placental tissue. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 84: 679-689. 2005

Keski-Nisula L, Hirvonen M-R, Roponen M, Heinonen S, Pekkanen J. 2004. Spontaneous and stimulated interleukin-6 and tumor necrosis factor-alpha production at delivery and three months after birth. EUROPEAN CYTOKINE NETWORK (MONTROUGE) 15 1: 67-72. 2004

Keski-Nisula L, Roponen M, Hirvonen M-R, Heinonen S, Pekkanen J. 2004. Stimulated cytokine production correlates in umbilical arterial venous blood at delivery. EUROPEAN CYTOKINE NETWORK (MONTROUGE) 4 15: 347-352. 2004

Toivonen S, Keski-Nisula L, Saarikoski S, Heinonen S. 2004. Risk of placental abruption in first-degree relatives of index patients. CLINICAL GENETICS (COPENHAGEN) 66: 244-246. 2004

Toivonen S, Romppanen E-L, Hiltunen M, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 11: 540-544. 2004

Jääskeläinen E, Toivonen S, Romppanen E-L, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. M385T polymorphism in the factor V gene, but not leiden mutation, is associated with placental abruption in finnish women PLACENTA (LONDON) 25: 730-734. 2004

Laurema A, Heikkilä A, Keski-Nisula L, Heikura T, Lehtolainen P, Manninen H, Tuomisto TT, Heinonen S, Ylä-Herttuala S. 2003. Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes GENE THERAPY 10: 580-584. 2003

Poutamo J, Keski-Nisula L, Kuopio T, Heinonen S. 2003. Amniocentesis - a routine procedure, but invasive. PRENATAL DIAGNOSIS 23: 762-770. 2003

Keski-Nisula LT, Aalto M-L, Kirkinen PP, Kosma V-M, Heinonen ST. 2003. Myometrial inflammation in human delivery and its association with labor and infection. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 120 2: 217-224. 2003

Keski-Nisula L, Hirvonen M-R, Roponen M, Heinonen S, Pekkanen J. 2003. Maternal and neonatal IL-4 and IFN-gamma production at delivery and 3 months after birth JOURNAL OF REPRODUCTIVE IMMUNOLOGY 60: 25-33. 2003

Heikkilä A, Myllynen P, Keski-Nisula L, Heinonen S, Vähäkangas K, Ylä-Herttuala S. 2002. Gene transfer to human placenta ex vivo: A novel application of dual perfusion of human placental cotyledon. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 186: 1046-1051. 2002

Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes. GENE THERAPY 8: 784-788. 2001

Keski-Nisula L, Aalto M-L, Katila M-L, Kirkinen P. 2000. Intrauterine inflammation at term: a histopathologic study. HUMAN PATHOLOGY (PHILADELPHIA PA) 31 7: 841-846. 2000

Keski-Nisula L, Kiekara O, Kirkinen P. 1999. Prenatal collapse of cysts in a dysplastic kidney. JOURNAL OF CLINICAL ULTRASOUND 27: 356-360. 1999

Keski-Nisula L, Katila M-L, Virén M, Kataja V, Katila T. 1998. Selvittämätön syöpä ja luustoetäpesäkkeet. DUODECIM 114: 777-781. 1998

Keski-Nisula L, Katila M-L, Kirkinen P, Ollikainen M, Saarikoski S. 1997. Amniotic fluid leukocytes and leukocyte esterase activity in parturients delivered by caesarean section. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 29: 291-296. 1997

Keski-Nisula L, Kirkinen P, Katila M-L, Ollikainen M, Saarikoski S. 1997. Cesarean delivery: Microbial colonization in amniotic fluid JOURNAL OF REPRODUCTIVE MEDICINE 42 2: 91-98. 1997

Keski-Nisula L, Kirkinen P, Katila M-L, Ollikainen M, Suonio S, Saarikoski S. 1997. Amniotic fluid U. urealyticum colonization: Significance for maternal peripartal infections at term. AMERICAN JOURNAL OF PERINATOLOGY 14 3: 151-156. 1997

Keski-Nisula L, Kirkinen P, Ollikainen M, Saarikoski S. 1997. C-reactive protein in uncomplicated parturients delivered by cesarean section. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 76: 862-867. 1997

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