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Marko Lehtonen

Marko Lehtonen

Tutkimusjohtaja

Farmasian laitos, Terveystieteiden tiedekunta

marko.lehtonen@uef.fi | 040 355 2250

Tiedot Julkaisut

Tutkimusryhmät

Farmasian analytiikkayksikkö 27.02.2020 -
LC-MS metabolomiikkakeskus 01.09.2023 -
Mikromuovitutkimus 01.09.2016 -

Projektit

Välitön altistus mikromuoveille ruoan ja elintarvikepakkausten kautta - muoveista liuenneet aineet ja niiden terveysvaikutukset (Dimpex) Päättynyt 01.09.2020 - 31.08.2024

Avainsanat

analyyyttinen kemia farmaseuttinen analytiikka GC-MS kemia kromatografia LC-MS lipidomiikka massaspektrometria metabolomiikka säilyvyys ja yhteensopivuus validointi

Julkaisut

115/115 kappaletta

Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes
Yli-Öyrä, Johanna; Juvonen, Risto O; Lehtonen, Marko; Herrala, Mikko; Finel, Moshe; Räisänen, Riikka; Rysä, Jaana. 2024. Basic and clinical pharmacology and toxicology. [Epub ahead of print 25 April 2024]: 1-12
Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease
Saarinen, Emmi K; Kuusimäki, Tomi; Lindholm, Kari; Niemi, Kalle; Honkanen, Emma A; Noponen, Tommi; Seppänen, Marko; Ihalainen, Toni; Murtomäki, Kirsi; Mertsalmi, Tuomas; Jaakkola, Elina; Myller, Elina; Eklund, Mikael; Nuuttila, Simo; Levo, Reeta; Chaudhuri, Kallol Ray; Antonini, Angelo; Vahlberg, Tero; Lehtonen, Marko; Joutsa, Juho; Scheperjans, Filip; Kaasinen, Valtteri. 2024. Annals of neurology. 96: 262-275
Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27:
Fasting plasma metabolites reflecting meat consumption and their associations with incident type 2 diabetes in two Swedish cohorts
Noerman, Stefania; Johansson, Anna; Shi, Lin; Lehtonen, Marko; Hanhineva, Kati; Johansson, Ingegerd; Brunius, Carl; Landberg, Rikard. 2024. American journal of clinical nutrition. 119: 1280-1292
Metabolic changes in response to varying whole-grain wheat and rye intake
Koistinen, Ville M; Haldar, Sumanto; Tuomainen, Marjo; Lehtonen, Marko; Klåvus, Anton; Draper, John; Lloyd, Amanda; Beckmann, Manfred; Bal, Wendy; Ross, Alastair B; Brandt, Kirsten; Fawcett, Lee; Seal, Chris; Hanhineva, Kati. 2024. npj science of food. 8: . 8
Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function
Hämäläinen, Kreetta; Hirvensalo, Päivi; Neuvonen, Mikko; Tornio, Aleksi; Backman, Janne T; Lehtonen, Marko; Niemi, Mikko. 2024. Cts: clinical and translational science. 17: 1-14
Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
Kiiski, Johanna I; Neuvonen, Mikko; Kurkela, Mika; Hirvensalo, Päivi; Hämäläinen, Kreetta; Tarkiainen, E Katriina; Sistonen, Johanna; Korhonen, Mari; Khan, Sofia; Orpana, Arto; Filppula, Anne M; Lehtonen, Marko; Niemi, Mikko. 2024. Human genomics. 18: . 11
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195:
The metabolic response of HepG2 cells to extracellular vesicles derived from Raphanus sativus L. var. caudatus Alef microgreens probed by chemometrics-assisted LC-MS/MS analysis
Kaimuangpak, Karnchanok; Srisongkram, Tarapong; Lehtonen, Marko; Rautio, Jarkko; Weerapreeyakul, Natthida. 2024. Food chemistry. 461:
Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study
Hintikka, Jukka E; Ahtiainen, Juha P; Permi, Perttu; Jalkanen, Sirpa; Lehtonen, Marko; Pekkala, Satu. 2023. Scientific reports. 13:
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192:
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Härkänen, Lasse; Hakomäki, Henriikka; Huopio, Jukka; Kokki, Hannu; Korhonen, Sanni; Lehtonen, Marko; Sjövall, Sari; Kokki, Merja. 2023. European journal of clinical pharmacology. 79: 1709-1711
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
U-Din, Mueez; de Mello, Vanessa D; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Amri, Ez-Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A. 2023. Cell reports. 42:
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232:
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
Driuchina, Anastasiia; Hintikka, Jukka; Lehtonen, Marko; Keski-Rahkonen, Pekka; O’Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari A; Mäkinen, Elina; Lensu, Sanna; Pietiläinen, Kirsi H; Pekkala, Satu. 2023. Mbio. 14: . e02663-22
Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet
Näätänen, Mari; Kårlund, Anna; Mikkonen, Santtu; Klåvus, Anton; Savolainen, Otto; Lehtonen, Marko; Karhunen, Leila; Hanhineva, Kati; Kolehmainen, Marjukka. 2023. Clinical nutrition. 42: 1126-1141
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija. 2023. Science advances. 9: 1-23
Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service
Vilanti, Anna; Helin-Tanninen, Minna; Isotalo, Antti; Mustonen, Juho; Koskivuori, Johanna; Korhonen, Ossi; Lehtonen, Marko. 2023. European journal of hospital pharmacy: science and practice. [Published Online First: 27 August 2023]:
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka. 2023. Molecular metabolism. 76:
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215:
Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy
Sahlman, H; Itkonen, A; Lehtonen, M; Keski-Nisula, L; Rysä, J. 2022. Placenta. 129: 30-35
Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing
Hakomäki, Henriikka; Eskola, Sophia; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Laaksonen, Sakari; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2022. European journal of pharmaceutical sciences. 178:
Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310:
Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Koistinen, Ville M.; Hedberg, Maria; Shi, Lin; Johansson, Anders; Savolainen, Otto; Lehtonen, Marko; Aura, Anna‐Marja; Hanhineva, Kati; Landberg, Rikard. 2022. Molecular nutrition and food research. 66:
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis
Nieminen, Petteri; Hämäläinen, Wilhelmiina; Savinainen, Juha; Lehtonen, Marko; Lehtiniemi, Saara; Rinta-Paavola, Juho; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Mustonen, Anne-Mari. 2022. Inflammation. 45: 1101-1117
Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy
Järvilehto, Julius; Harjuhaahto, Sandra; Palu, Edouard; Auranen, Mari; Kvist, Jouni; Zetterberg, Henrik; Koskivuori, Johanna; Lehtonen, Marko; Saukkonen, Anna Maija; Jokela, Manu; Ylikallio, Emil; Tyynismaa, Henna. 2022. Frontiers in neurology. 13: . 793937
Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study
Noerman, Stefania; Virtanen, Jyrki K.; Lehtonen, Marko; Brunius, Carl; Hanhineva, Kati. 2022. European journal of nutrition. 2023; 62: 713-726
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018
Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180
Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Toxicology and applied pharmacology. 370: 56-64
In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N. 2019. Molecules. 24: 2191
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition. 110: 1108-1118
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports. 8: 14616
A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy
Purdy, Martin; Kinnunen, Mari; Kokki, Merja; Anttila, Maarit; Eskelinen, Matti; Hautajärvi, Heidi; Lehtonen, Marko; Kokki, Hannu. 2018. Medicine. 97: e9968
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology. 223: 79-84
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979
Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine
Puurunen, Jenni; Tiira, Katriina; Vapalahti, Katarooma; Lehtonen, Marko; Hanhineva, Kati; Lohi, Hannes. 2018. Scientific reports. 8: 15976
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Cardiovascular research. 2019; 115: 107-118
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK. 2018. Molecular nutrition and food research. 2019; 63: 1800605
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia. 61: 849-861
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036
Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study
Piirainen A, Kokki M, Lidsle HM, Lehtonen M, Ranta VP, Kokki H. 2017. Current medical research and opinion. 2018; 34: 683-688
Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats
Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM. 2017. Journal of neuroscience research. 95: 1858-1870
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat
Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology. 119: 15-25
Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Molecular nutrition and food research. 61: 1700019
High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)
Sangthonga S, Weerapreeyakulb N, Lehtonen M, Leppanen J, Rautio J. 2017. Journal of functional foods. 31: 237-247
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337
A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
Puurunen Jenni, Sulkama Sini, Tiira Katriina, Araujo Cesar, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 27
Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
Gynther Mikko, Peura Lauri, Vernerová Monika, Leppänen Jukka, Kärkkäinen Jussi, Lehtonen Marko, Rautio Jarkko, Huttunen Kristiina M. 2016. Neurochemical research. 41: 2797-2809
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
Krasavin Mikhail, Lukin Alexey, Bagnyukova Daria, Zhurilo Nikolay, Zahanich Ihor, Zozulya Sergey, Ihalainen Jouni, Forsberg Markus M, Lehtonen Marko, Rautio Jarkko, Moore Daniel, Tikhonova Irina G. 2016. Bioorganic and medicinal chemistry. 24: 5481-5494
In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
Aaltonen Niina, Kedzierska Ewa, Orzelska-Gorka Jolanta, Lehtonen Marko, Navia-Paldanius Dina, Jakupovic Hermina, Savinainen Juha, Nevalainen Tapio, Laitinen Jarmo T, Parkkari Teija, Gynther Mikko. 2016. Journal of pharmacology and experimental therapeutics. 359: 62-72
Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia
Kårlund Anna, Moor Ulvi, McDougall Gordon, Lehtonen Marko, Karjalainen Reijo O, Hanhineva Kati. 2016. Food research international. 89: 647-653
Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, McDougall Gordon J, Stewart Derek, Karjalainen Reijo O. 2016. Journal of the science of food and agriculture. 2017; 97: 2182-2190
Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs
Puurunen Jenni, Tiira Katriina, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 7
Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases
Lehtonen ¦árka, Lehtonen Marko, Koistinaho Jari. Teoksessa: Tomizava Minoru(toim.) , 2016. Pluripotent Stem Cells - From the Bench to the Clinic. s. 209-226. InTech Open
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach
Tovar Juscelino, de Mello Vanessa D, Nilsson Anne, Johansson Maria, Paananen Jussi, Lehtonen Marko, Hanhineva Kati, Björck Inger. 2016. Molecular nutrition and food research. [Epub ahead of print 8 Nov 2016]: 1-12
The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty
Piirainen Annika, Kokki Merja, Hautajärvi Heidi, Lehtonen Marko, Miettinen Hannu, Pulkki Kari, Ranta Veli-Pekka, Kokki Hannu. 2016. Clinical drug investigation. 36: 545-555
Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet - a non-targeted metabolomics study
Pekkinen Jenna, Rosa-Sibakov Natalia, Micard Valerie, Keski-Rahkonen Pekka, Lehtonen Marko, Poutanen Kaisa, Mykkänen Hannu, Hanhineva Kati. 2015. Molecular nutrition and food research. 59: 1550-1562
Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System
Lehtonen Marko. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE. 10: e0124379
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase
Navia-Paldanius Dina, Aaltonen Niina, Lehtonen Marko, Savinainen Juha R, Taschler Ulrike, Radner Franz PW, Zimmermann Robert, Laitinen Jarmo T. 2015. European journal of pharmaceutical sciences. 77: 180-188
Nontargeted Metabolite Profiles and Sensory Properties of Strawberry Cultivars Grown both Organically and Conventionally
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, Karjalainen Reijo O, Sandell Mari. 2015. Journal of agricultural and food chemistry. 63: 1010-1019
Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib
Riikonen Joakim, Correia Alexandra, Kovalainen Miia, Näkki Simo, Lehtonen Marko, Leppänen Jukka, Rantanen Jimi, Xu Wujun, Araújo Francisca, Hirvonen Jouni, Järvinen Kristiina, Santos Hélder A, Lehto Vesa-Pekka. 2015. Biomaterials. 52: 44-55
Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma
Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M. 2014. Drug metabolism and disposition. 2015; 43: 140-146
Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)
Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. PLoS ONE. 9: e98286
Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial
Hanhineva Kati, Lankinen Maria A, Pedret Anna, Schwab Ursula, Kolehmainen Marjukka, Paananen Jussi, de Mello Vanessa, Sola Rosa, Lehtonen Marko, Poutanen Kaisa, Uusitupa Matti, Mykkänen Hannu. 2014. Journal of nutrition. 2015; 145: 7-17
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)
Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Molecular pharmacology. Epub ahead of print: -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content analysis during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. Journal of pharmaceutical and biomedical analysis. 95: 229-237
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014.
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research. 57: 1959-1968
Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice
Aaltonen Niina, Ribas Casandra R, Lehtonen Marko, Savinainen Juha R, Laitinen Jarmo T. 2013. European journal of pharmaceutical sciences. 2014:51: 87-95
Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics
Kärkkäinen Olli K, Lehtonen Marko, Laukkanen Virpi, Tupala Erkki, Hyytiä Petri, Kautiainen Hannu, Tiihonen Jari, Callaway JC, Storvik Markus. 2013. Alcohol. 47: 399-403
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Chemistry and biology. 20: 379-390
Quantification of endocannabinoids in postmortem brain of schizophrenic subjects
Muguruza Carolina, Lehtonen Marko, Aaltonen Niina, Morentin Benito, Meana J. Javier, Callado Luis F. 2013. Schizophrenia research. 148: 145-150
Stability of an epidural analgesic admixture of levobupivacaine, fentanyl and epinephrine
Helin-Tanninen Minna, Lehtonen Marko, Naaranlahti Toivo, Venäläinen Tetta, Pentikäinen J, Laatikainen A, Kokki Hannu. 2013. Journal of clinical pharmacy and therapeutics. 38: 104-108
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. EUFEPS
Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation
Aaltonen Niina, Lehtonen Marko, Varonen Katri, Goterris Gemma Arrufat, Laitinen Jarmo T. 2012. Bmc pharmacology. 12: 7
Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children
Välitalo Pyry, Kumpulainen Elina, Manner Minna, Kokki Merja, Lehtonen Marko, Hooker Andrew C, Ranta Veli-Pekka, Kokki Hannu. 2012. Journal of clinical pharmacology. 52: 1516-1526
The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits
Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. European journal of pharmaceutics and biopharmaceutics. 81: 178-183
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat
Jalkanen Aaro J, Hakkarainen Jenni J, Lehtonen Marko, Venäläinen Tetta, Kääriäinen Tiina M, Jarho Elina, Suhonen Marjukka, Forsberg Markus M. 2011. Basic and clinical pharmacology and toxicology. 109: 443-451
Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3
Reisner Kaja, Lehtonen Marko, Storvik Markus, Jantson Tanel, Lakso Merja, Callaway James C, Wong Garry. 2011. Journal of biochemical and molecular toxicology. 25: 269-279
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis
Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. Journal of neuroscience methods. 189: 210 - 215
Brain uptake of ketoprofen-lysine prodrug in rats
Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. International journal of pharmaceutics. 399: 121-128
Celastrol: Molecular targets of Thunder God Vine
Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Biochemical and biophysical research communications. 394: 439 - 442
Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor
Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Bioorganic and medicinal chemistry letters. 20: 2614 - 2616
Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics
Lehtonen M, Storvik M, Tupala E, Hyytiä P, Tiihonen J & Callaway JC. 2010. European neuropsychopharmacology. 20: 245 - 252
Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans
Aarnio V, Storvik M, Lehtonen M, Asikainen S, Reisner K, Callaway J, Rudgalvyte M, Lakso M & Wong G. 2010. Comparative biochemistry and physiology c: toxicology and pharmacology. 151: 318 - 324
Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children
Kumpulainen E, Välitalo P, Kokki M, Lehtonen M, Hooker A, Ranta V-P & Kokki H. 2010. British journal of clinical pharmacology. 70: 557-566
Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry
Aaltonen N, Laitinen JT & Lehtonen M. 2010. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 878: 1145 - 1152
Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, Horrighs A, Lehtonen M, Tennagels N, Eckel J. 2009. Diabetologia. 52: 664-674
Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats
Malinen H, Lehtonen M, Hyytiä Petri. 2009. Alcoholism-clinical and experimental research. 33: 1711-1720
Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration
Turunen E, Lehtonen M, Järvinen T, Jarho P. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 872: 51-57
Diclofenac readily penetrates the cerebrospinal fluid in children
Kokki H, Kumpulainen E, Laisalmi M, Savolainen J, Rautio J, Lehtonen M. 2008. British journal of clinical pharmacology. 65: 879-884
How readily does ketorolac penetrate cerebrospinal fluid in children?
Kumpulainen E, Kokki H, Laisalmi M, Heikkinen M, Savolainen J, Rautio J, Lehtonen M. 2008. Journal of clinical pharmacology. 48: 495-501
Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes
Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Chemistry and biodiversity. 5: 2431-2441
Quantitative analysis of natural cyclodextrins by high-performance liquid chromatography with pulsed amperometric detection: Application to cell permeation study
Toropainen T, Jarho P, Lehtonen M, Keski-Rahkonen P, Raatikainen H, Järvinen T. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 867: 90-98
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry
Annola K, Keski-Rahkonen P, Vähäkangas K, Lehtonen M. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 876: 191-197
Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Cellular and molecular life sciences. 65: 2979-2999
Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children
Kokki H, Kumpulainen E, Lehtonen M, Laisalmi M, Heikkinen M, Savolainen J, Rautio J. 2007. Pediatrics. 120: e1002-e1008
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats
Kääriäinen TM, Lehtonen M, Forsberg MM, Savolainen J, Käenmäki M, Männistö PT. 2007. Basic and clinical pharmacology and toxicology. 102: 50-58
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry
Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 43: 606-612
Early-phase pharmacokinetics of enteral and parenteral nimodipine in patients with acute subarachnoid haemorrhage - a pilot study
Soppi V, Kokki H, Koivisto T, Lehtonen M, Helin-Tanninen M, Lehtola S, Rinne J. 2007. European journal of clinical pharmacology. 63: 355-361
Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration
Mannila A, Kumpulainen E, Lehtonen M, Heikkinen M, Laisalmi M, Salo T, Rautio J, Savolainen J, Kokki H. 2007. Journal of clinical pharmacology. 47: 94-100
Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry
Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. 2007. Rapid communications in mass spectrometry. 21: 2933-2943
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography
Palomäki VAB, Lehtonen M, Savinainen JR, Laitinen JT. 2007. Journal of neurochemistry. 101: 972-981
Cerebrospinal fluid distribution of ketoprofen after intravenous administration in young children
Mannila A, Kokki H, Heikkinen M, Laisalmi M, Lehtonen M, Louhisto HL, Järvinen T, Savolainen J. 2006. Clinical pharmacokinetics. 45: 737-743
Controlled release of saccharides from matrix tablets
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 62: 163-170
Convenient microwave-assisted synthesis of 1-chloroethyl phosphates
Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J. 2006. Tetrahedron letters. 47: 2003-2004
Influence of tamsulosin on the iris and its implications for cataract surgery
Pärssinen O, Leppänen E, Keski-Rahkonen P, Mauriala T, Dugué B, Lehtonen M. 2006. Investigative ophthalmology and visual science. 47: 3766-3771
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain
Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT. 2006. Chemistry and biology. 13: 811-814
An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates
Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J. 2005. Journal of organic chemistry. 70: 9056-9058
Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
Mannila A, Rautio J, Lehtonen M, Järvinen T, Savolainen J. 2005. European journal of pharmaceutical sciences. 24: 101-105
Determination of delta9 -tetrahydrocannabinol from rabbit plasma by gas chromatography-mass spectrometry using two ionization techniques
Mannila J, Lehtonen M, Järvinen T, Jarho P. 2004. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 810: 283-290
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat
Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Järvinen T, Männistö PT. 2003. Journal of pharmacology and experimental therapeutics. 304: 498-506

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Näytä asetukset

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Tarkenna hakuasi

Marko Lehtonen

Tutkimusryhmät

Projektit

Avainsanat

Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes

Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Fasting plasma metabolites reflecting meat consumption and their associations with incident type 2 diabetes in two Swedish cohorts

Metabolic changes in response to varying whole-grain wheat and rye intake

Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

The metabolic response of HepG2 cells to extracellular vesicles derived from Raphanus sativus L. var. caudatus Alef microgreens probed by chemometrics-assisted LC-MS/MS analysis

Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study

Altering distribution profile of palbociclib by its prodrugs

Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy

Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth

Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis

Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy

Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine

Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure

Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835

In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia

Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds

Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs

Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases

Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach

The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty

Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet - a non-targeted metabolomics study

Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System

CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase

Nontargeted Metabolite Profiles and Sensory Properties of Strawberry Cultivars Grown both Organically and Conventionally

Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib

Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)

Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial

Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)

Validation of a multipoint near-infrared spectroscopy method for in-line moisture content analysis during freeze-drying

Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying

Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach

Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice

Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase

Quantification of endocannabinoids in postmortem brain of schizophrenic subjects