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Marko Lehtonen

Marko Lehtonen

Research Director

School of Pharmacy, Faculty of Health Sciences

[email protected] | +358 40 355 2250

Information Publications

Research groups

Analytical unit of the school of Pharmacy 27.02.2020 -
LC-MS metabolomics center 01.09.2023 -
Microplastic research 01.09.2016 -

Projects

Direct microplastic exposure via foodstuff and food packaging - plastic leachables and their health effects (diMPex) Finished 01.09.2020 - 31.08.2024

Keywords

analytical chemistry chemistry chromatography GC-MS LC-MS lipidomics mass spectrometry metabolomics pharmaceutical analysis stability and compatibility validation

Publications

136/136 items

Unraveled cancer cell survival-associated amino acid metabolism of HepG2 cells altered by Thai rat-tailed radish microgreen extract examined by untargeted LC-MS/MS analysis
Kaimuangpak, Karnchanok; Lehtonen, Marko; Rautio, Jarkko; Weerapreeyakul, Natthida. 2025. Food chemistry. 474: A1 Journal article (refereed), original research
Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes
Yli-Öyrä, Johanna; Juvonen, Risto O; Lehtonen, Marko; Herrala, Mikko; Finel, Moshe; Räisänen, Riikka; Rysä, Jaana. 2024. Basic and clinical pharmacology and toxicology. 134: 846-857 A1 Journal article (refereed), original research
Associations of gestational anxiety and depression with neonatal hair steroid levels
Chortatos, Arthur; Vittersø, Axel Davies; Uusitalo, Lauri; Lehtonen, Marko; Huotari, Johanna; Auriola, Seppo; Voutilainen, Raimo; Backman, Katri; Keski-Nisula, Leea; Lehto, Soili M. 2024. Psychoneuroendocrinology. 2025; 172: A1 Journal article (refereed), original research
Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease
Saarinen, Emmi K; Kuusimäki, Tomi; Lindholm, Kari; Niemi, Kalle; Honkanen, Emma A; Noponen, Tommi; Seppänen, Marko; Ihalainen, Toni; Murtomäki, Kirsi; Mertsalmi, Tuomas; Jaakkola, Elina; Myller, Elina; Eklund, Mikael; Nuuttila, Simo; Levo, Reeta; Chaudhuri, Kallol Ray; Antonini, Angelo; Vahlberg, Tero; Lehtonen, Marko; Joutsa, Juho; Scheperjans, Filip; Kaasinen, Valtteri. 2024. Annals of neurology. 96: 262-275 A1 Journal article (refereed), original research
Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: A1 Journal article (refereed), original research
Fasting plasma metabolites reflecting meat consumption and their associations with incident type 2 diabetes in two Swedish cohorts
Noerman, Stefania; Johansson, Anna; Shi, Lin; Lehtonen, Marko; Hanhineva, Kati; Johansson, Ingegerd; Brunius, Carl; Landberg, Rikard. 2024. American journal of clinical nutrition. 119: 1280-1292 A1 Journal article (refereed), original research
Metabolic changes in response to varying whole-grain wheat and rye intake
Koistinen, Ville M; Haldar, Sumanto; Tuomainen, Marjo; Lehtonen, Marko; Klåvus, Anton; Draper, John; Lloyd, Amanda; Beckmann, Manfred; Bal, Wendy; Ross, Alastair B; Brandt, Kirsten; Fawcett, Lee; Seal, Chris; Hanhineva, Kati. 2024. npj science of food. 8: . 8 A1 Journal article (refereed), original research
Metabolic signatures of metabolic dysfunction-associated steatotic liver disease in severely obese patients
Babu, Ambrin Farizah; Palomurto, Saana; Kärjä, Vesa; Käkelä, Pirjo; Lehtonen, Marko; Hanhineva, Kati; Pihlajamäki, Jussi; Männistö, Ville. 2024. Digestive and liver disease. 56: 2103-2110 A1 Journal article (refereed), original research
Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function
Hämäläinen, Kreetta; Hirvensalo, Päivi; Neuvonen, Mikko; Tornio, Aleksi; Backman, Janne T; Lehtonen, Marko; Niemi, Mikko. 2024. Cts: clinical and translational science. 17: 1-14 A1 Journal article (refereed), original research
Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson's Disease
Zhang, Yinjia; Hämäläinen, Wilhelmiina; Reinikka, Paavo; Herukka, Sanna Kaisa; Leinonen, Ville; Lehtonen, Marko; Lehtonen, Šárka. Teoksessa: Cannataro, Mario; Zheng, Huiru (Jane); Gao, Lin; Cheng, Jianlin (Jack); de Miranda, João Luís; Zumpano, Ester; Hu, Xiaohua; Cho, Young-Rae; Park, Taesung(toim.) , 2024. Proceedings: 2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024. s. 5884-5891. A4 Conference proceedings
Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
Kiiski, Johanna I; Neuvonen, Mikko; Kurkela, Mika; Hirvensalo, Päivi; Hämäläinen, Kreetta; Tarkiainen, E Katriina; Sistonen, Johanna; Korhonen, Mari; Khan, Sofia; Orpana, Arto; Filppula, Anne M; Lehtonen, Marko; Niemi, Mikko. 2024. Human genomics. 18: . 11 A1 Journal article (refereed), original research
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195: A1 Journal article (refereed), original research
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 203: A1 Journal article (refereed), original research
The metabolic response of HepG2 cells to extracellular vesicles derived from Raphanus sativus L. var. caudatus Alef microgreens probed by chemometrics-assisted LC-MS/MS analysis
Kaimuangpak, Karnchanok; Srisongkram, Tarapong; Lehtonen, Marko; Rautio, Jarkko; Weerapreeyakul, Natthida. 2024. Food chemistry. 461: A1 Journal article (refereed), original research
Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study
Hintikka, Jukka E; Ahtiainen, Juha P; Permi, Perttu; Jalkanen, Sirpa; Lehtonen, Marko; Pekkala, Satu. 2023. Scientific reports. 13: A1 Journal article (refereed), original research
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192: A1 Journal article (refereed), original research
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Härkänen, Lasse; Hakomäki, Henriikka; Huopio, Jukka; Kokki, Hannu; Korhonen, Sanni; Lehtonen, Marko; Sjövall, Sari; Kokki, Merja. 2023. European journal of clinical pharmacology. 79: 1709-1711 A1 Journal article (refereed), original research
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
U-Din, Mueez; de Mello, Vanessa D; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Amri, Ez-Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A. 2023. Cell reports. 42: A1 Journal article (refereed), original research
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232: A1 Journal article (refereed), original research
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
Driuchina, Anastasiia; Hintikka, Jukka; Lehtonen, Marko; Keski-Rahkonen, Pekka; O’Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari A; Mäkinen, Elina; Lensu, Sanna; Pietiläinen, Kirsi H; Pekkala, Satu. 2023. Mbio. 14: . e02663-22 A1 Journal article (refereed), original research
Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet
Näätänen, Mari; Kårlund, Anna; Mikkonen, Santtu; Klåvus, Anton; Savolainen, Otto; Lehtonen, Marko; Karhunen, Leila; Hanhineva, Kati; Kolehmainen, Marjukka. 2023. Clinical nutrition. 42: 1126-1141 A1 Journal article (refereed), original research
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija. 2023. Science advances. 9: 1-23 A1 Journal article (refereed), original research
Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service
Vilanti, Anna; Helin-Tanninen, Minna; Isotalo, Antti; Mustonen, Juho; Koskivuori, Johanna; Korhonen, Ossi; Lehtonen, Marko. 2023. European journal of hospital pharmacy: science and practice. [Published Online First: 27 August 2023]: A1 Journal article (refereed), original research
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38 A1 Journal article (refereed), original research
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka. 2023. Molecular metabolism. 76: A1 Journal article (refereed), original research
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215: A1 Journal article (refereed), original research
Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy
Sahlman, H; Itkonen, A; Lehtonen, M; Keski-Nisula, L; Rysä, J. 2022. Placenta. 129: 30-35 A1 Journal article (refereed), original research
Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing
Hakomäki, Henriikka; Eskola, Sophia; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Laaksonen, Sakari; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2022. European journal of pharmaceutical sciences. 178: A1 Journal article (refereed), original research
Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310: A1 Journal article (refereed), original research
Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Koistinen, Ville M.; Hedberg, Maria; Shi, Lin; Johansson, Anders; Savolainen, Otto; Lehtonen, Marko; Aura, Anna‐Marja; Hanhineva, Kati; Landberg, Rikard. 2022. Molecular nutrition and food research. 66: A1 Journal article (refereed), original research
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis
Nieminen, Petteri; Hämäläinen, Wilhelmiina; Savinainen, Juha; Lehtonen, Marko; Lehtiniemi, Saara; Rinta-Paavola, Juho; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Mustonen, Anne-Mari. 2022. Inflammation. 45: 1101-1117 A1 Journal article (refereed), original research
Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy
Järvilehto, Julius; Harjuhaahto, Sandra; Palu, Edouard; Auranen, Mari; Kvist, Jouni; Zetterberg, Henrik; Koskivuori, Johanna; Lehtonen, Marko; Saukkonen, Anna Maija; Jokela, Manu; Ylikallio, Emil; Tyynismaa, Henna. 2022. Frontiers in neurology. 13: . 793937 A1 Journal article (refereed), original research
Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study
Noerman, Stefania; Virtanen, Jyrki K.; Lehtonen, Marko; Brunius, Carl; Hanhineva, Kati. 2022. European journal of nutrition. 2023; 62: 713-726 A1 Journal article (refereed), original research
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 A1 Journal article (refereed), original research
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. Metabolomics
Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease
Noerman, Stefania; Kokla, Marietta; Koistinen, Ville M; Lehtonen, Marko; Tuomainen, Tomi-Pekka; Brunius, Carl; Virtanen, Jyrki K; Hanhineva, Kati. 2021. Clinical nutrition
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder
Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo. 2021. Alcoholism-clinical and experimental research
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)
Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. International journal of molecular sciences
Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome
Herrala, Maria; Turunen, Soile; Hanhineva, Kati; Lehtonen, Marko; Mikkonen, Jopi J. W.; Seitsalo, Hubertus; Lappalainen, Reijo; Tjäderhane, Leo; Niemelä, Raija K.; Salo, Tuula; Myllymaa, Sami; Kullaa, Arja M.; Kärkkäinen, Olli. 2021. Metabolites
Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep
Hakomäki, Henriikka; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2021. European journal of pharmaceutical sciences
Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation
Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Bioorganic chemistry
Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection
Hakomäki, Henriikka; Kokki; Hannu; Lehtonen, Marko; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2021. Pharmacology research & perspectives
Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
Jalkanen, Aaro J.; Ihalainen, Jouni; Lehtonen, Marko; Forsberg, Markus M.; Rautio, Jarkko; Huttunen, Kristiina M.; Gynther, Mikko. 2021. International journal of pharmaceutics
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. European journal of nutrition
Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up
Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. 2020. Alcoholism-clinical and experimental research
Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study
Juvonen, RO; Jokinen, EM; Javaid, A; Lehtonen, M; Raunio, H; Pentikäinen, OT. 2020. Chemical biology and drug design
L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells
Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. Acs chemical neuroscience
L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels
Montaser, Ahmed; Lehtonen, Marko; Gynther, Mikko; Huttunen, Kristiina. 2020. Pharmaceutics
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, ¦árka. 2020. Scientific reports
Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone
Jalkanen, Aaro; Lassheikki, Veera; Torsti, Tommi; Gharib, Elham; Lehtonen, Marko; Juvonen, Risto O. 2020. Xenobiotica
Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180
Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Toxicology and applied pharmacology
In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N. 2019. Molecules
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports
A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy
Purdy, Martin; Kinnunen, Mari; Kokki, Merja; Anttila, Maarit; Eskelinen, Matti; Hautajärvi, Heidi; Lehtonen, Marko; Kokki, Hannu. 2018. Medicine
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition
Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine
Puurunen, Jenni; Tiira, Katriina; Vapalahti, Katarooma; Lehtonen, Marko; Hanhineva, Kati; Lohi, Hannes. 2018. Scientific reports
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Cardiovascular research
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK. 2018. Molecular nutrition and food research
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports
Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study
Piirainen A, Kokki M, Lidsle HM, Lehtonen M, Ranta VP, Kokki H. 2017. Current medical research and opinion
Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats
Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM. 2017. Journal of neuroscience research
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat
Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology
Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Molecular nutrition and food research
High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)
Sangthonga S, Weerapreeyakulb N, Lehtonen M, Leppanen J, Rautio J. 2017. Journal of functional foods
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports
A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
Puurunen Jenni, Sulkama Sini, Tiira Katriina, Araujo Cesar, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions
Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
Gynther Mikko, Peura Lauri, Vernerová Monika, Leppänen Jukka, Kärkkäinen Jussi, Lehtonen Marko, Rautio Jarkko, Huttunen Kristiina M. 2016. Neurochemical research
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
Krasavin Mikhail, Lukin Alexey, Bagnyukova Daria, Zhurilo Nikolay, Zahanich Ihor, Zozulya Sergey, Ihalainen Jouni, Forsberg Markus M, Lehtonen Marko, Rautio Jarkko, Moore Daniel, Tikhonova Irina G. 2016. Bioorganic and medicinal chemistry
In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
Aaltonen Niina, Kedzierska Ewa, Orzelska-Gorka Jolanta, Lehtonen Marko, Navia-Paldanius Dina, Jakupovic Hermina, Savinainen Juha, Nevalainen Tapio, Laitinen Jarmo T, Parkkari Teija, Gynther Mikko. 2016. Journal of pharmacology and experimental therapeutics
Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia
Kårlund Anna, Moor Ulvi, McDougall Gordon, Lehtonen Marko, Karjalainen Reijo O, Hanhineva Kati. 2016. Food research international
Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, McDougall Gordon J, Stewart Derek, Karjalainen Reijo O. 2016. Journal of the science of food and agriculture
Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs
Puurunen Jenni, Tiira Katriina, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions
Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases
Lehtonen ¦árka, Lehtonen Marko, Koistinaho Jari. 2016. InTech Open
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach
Tovar Juscelino, de Mello Vanessa D, Nilsson Anne, Johansson Maria, Paananen Jussi, Lehtonen Marko, Hanhineva Kati, Björck Inger. 2016. Molecular nutrition and food research
The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty
Piirainen Annika, Kokki Merja, Hautajärvi Heidi, Lehtonen Marko, Miettinen Hannu, Pulkki Kari, Ranta Veli-Pekka, Kokki Hannu. 2016. Clinical drug investigation
Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet - a non-targeted metabolomics study
Pekkinen Jenna, Rosa-Sibakov Natalia, Micard Valerie, Keski-Rahkonen Pekka, Lehtonen Marko, Poutanen Kaisa, Mykkänen Hannu, Hanhineva Kati. 2015. Molecular nutrition and food research
Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System
Lehtonen Marko. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase
Navia-Paldanius Dina, Aaltonen Niina, Lehtonen Marko, Savinainen Juha R, Taschler Ulrike, Radner Franz PW, Zimmermann Robert, Laitinen Jarmo T. 2015. European journal of pharmaceutical sciences
Nontargeted Metabolite Profiles and Sensory Properties of Strawberry Cultivars Grown both Organically and Conventionally
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, Karjalainen Reijo O, Sandell Mari. 2015. Journal of agricultural and food chemistry
Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib
Riikonen Joakim, Correia Alexandra, Kovalainen Miia, Näkki Simo, Lehtonen Marko, Leppänen Jukka, Rantanen Jimi, Xu Wujun, Araújo Francisca, Hirvonen Jouni, Järvinen Kristiina, Santos Hélder A, Lehto Vesa-Pekka. 2015. Biomaterials
Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma
Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M. 2014. Drug metabolism and disposition
Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)
Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. PLoS ONE
Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial
Hanhineva Kati, Lankinen Maria A, Pedret Anna, Schwab Ursula, Kolehmainen Marjukka, Paananen Jussi, de Mello Vanessa, Sola Rosa, Lehtonen Marko, Poutanen Kaisa, Uusitupa Matti, Mykkänen Hannu. 2014. Journal of nutrition
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)
Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Molecular pharmacology
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content analysis during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. Journal of pharmaceutical and biomedical analysis
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research
Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice
Aaltonen Niina, Ribas Casandra R, Lehtonen Marko, Savinainen Juha R, Laitinen Jarmo T. 2013. European journal of pharmaceutical sciences
Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics
Kärkkäinen Olli K, Lehtonen Marko, Laukkanen Virpi, Tupala Erkki, Hyytiä Petri, Kautiainen Hannu, Tiihonen Jari, Callaway JC, Storvik Markus. 2013. Alcohol
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Chemistry and biology
Quantification of endocannabinoids in postmortem brain of schizophrenic subjects
Muguruza Carolina, Lehtonen Marko, Aaltonen Niina, Morentin Benito, Meana J. Javier, Callado Luis F. 2013. Schizophrenia research
Stability of an epidural analgesic admixture of levobupivacaine, fentanyl and epinephrine
Helin-Tanninen Minna, Lehtonen Marko, Naaranlahti Toivo, Venäläinen Tetta, Pentikäinen J, Laatikainen A, Kokki Hannu. 2013. Journal of clinical pharmacy and therapeutics
Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation
Aaltonen Niina, Lehtonen Marko, Varonen Katri, Goterris Gemma Arrufat, Laitinen Jarmo T. 2012. Bmc pharmacology
Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children
Välitalo Pyry, Kumpulainen Elina, Manner Minna, Kokki Merja, Lehtonen Marko, Hooker Andrew C, Ranta Veli-Pekka, Kokki Hannu. 2012. Journal of clinical pharmacology
The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits
Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. European journal of pharmaceutics and biopharmaceutics
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat
Jalkanen Aaro J, Hakkarainen Jenni J, Lehtonen Marko, Venäläinen Tetta, Kääriäinen Tiina M, Jarho Elina, Suhonen Marjukka, Forsberg Markus M. 2011. Basic and clinical pharmacology and toxicology
Caenorhabditis elegans mutants predict regulation of fatty acids and endocannabinoids by the CYP-35A gene family
Aarnio Vuokko, Lehtonen Marko, Storvik Markus, Callaway James C, Lakso Merja, Wong Garry. 2011. Frontiers in pharmacology
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry
Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam
Kaartama Ruut, Jarho Pekka, Savolainen Jouko, Kokki Hannu, Lehtonen Marko. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats
Ihalainen Jouni, Sarajärvi Timo, Rasmusson Doug, Kemppainen Susanna, Keski-Rahkonen Pekka, Lehtonen Marko, Banerjee Pradeep K, Semba Kazue, Tanila Heikki. 2011. Neuropharmacology
Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3
Reisner Kaja, Lehtonen Marko, Storvik Markus, Jantson Tanel, Lakso Merja, Callaway James C, Wong Garry. 2011. Journal of biochemical and molecular toxicology
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis
Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. Journal of neuroscience methods
Celastrol: Molecular targets of Thunder God Vine
Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Biochemical and biophysical research communications
Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor
Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Bioorganic and medicinal chemistry letters
Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics
Lehtonen M, Storvik M, Tupala E, Hyytiä P, Tiihonen J & Callaway JC. 2010. European neuropsychopharmacology
Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans
Aarnio V, Storvik M, Lehtonen M, Asikainen S, Reisner K, Callaway J, Rudgalvyte M, Lakso M & Wong G. 2010. Comparative biochemistry and physiology c: toxicology and pharmacology
Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry
Aaltonen N, Laitinen JT & Lehtonen M. 2010. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, Horrighs A, Lehtonen M, Tennagels N, Eckel J. 2009. Diabetologia
Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats
Malinen H, Lehtonen M, Hyytiä Petri. 2009. Alcoholism-clinical and experimental research
Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration
Turunen E, Lehtonen M, Järvinen T, Jarho P. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Diclofenac readily penetrates the cerebrospinal fluid in children
Kokki H, Kumpulainen E, Laisalmi M, Savolainen J, Rautio J, Lehtonen M. 2008. British journal of clinical pharmacology
How readily does ketorolac penetrate cerebrospinal fluid in children?
Kumpulainen E, Kokki H, Laisalmi M, Heikkinen M, Savolainen J, Rautio J, Lehtonen M. 2008. Journal of clinical pharmacology
Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes
Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Chemistry and biodiversity
Quantitative analysis of natural cyclodextrins by high-performance liquid chromatography with pulsed amperometric detection: Application to cell permeation study
Toropainen T, Jarho P, Lehtonen M, Keski-Rahkonen P, Raatikainen H, Järvinen T. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry
Annola K, Keski-Rahkonen P, Vähäkangas K, Lehtonen M. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Cellular and molecular life sciences
Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children
Kokki H, Kumpulainen E, Lehtonen M, Laisalmi M, Heikkinen M, Savolainen J, Rautio J. 2007. Pediatrics
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats
Kääriäinen TM, Lehtonen M, Forsberg MM, Savolainen J, Käenmäki M, Männistö PT. 2007. Basic and clinical pharmacology and toxicology
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry
Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis
Early-phase pharmacokinetics of enteral and parenteral nimodipine in patients with acute subarachnoid haemorrhage - a pilot study
Soppi V, Kokki H, Koivisto T, Lehtonen M, Helin-Tanninen M, Lehtola S, Rinne J. 2007. European journal of clinical pharmacology
Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration
Mannila A, Kumpulainen E, Lehtonen M, Heikkinen M, Laisalmi M, Salo T, Rautio J, Savolainen J, Kokki H. 2007. Journal of clinical pharmacology
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography
Palomäki VAB, Lehtonen M, Savinainen JR, Laitinen JT. 2007. Journal of neurochemistry
Cerebrospinal fluid distribution of ketoprofen after intravenous administration in young children
Mannila A, Kokki H, Heikkinen M, Laisalmi M, Lehtonen M, Louhisto HL, Järvinen T, Savolainen J. 2006. Clinical pharmacokinetics
Controlled release of saccharides from matrix tablets
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics
Convenient microwave-assisted synthesis of 1-chloroethyl phosphates
Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J. 2006. Tetrahedron letters
Influence of tamsulosin on the iris and its implications for cataract surgery
Pärssinen O, Leppänen E, Keski-Rahkonen P, Mauriala T, Dugué B, Lehtonen M. 2006. Investigative ophthalmology and visual science
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain
Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT. 2006. Chemistry and biology
An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates
Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J. 2005. Journal of organic chemistry
Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
Mannila A, Rautio J, Lehtonen M, Järvinen T, Savolainen J. 2005. European journal of pharmaceutical sciences
Determination of delta9 -tetrahydrocannabinol from rabbit plasma by gas chromatography-mass spectrometry using two ionization techniques
Mannila J, Lehtonen M, Järvinen T, Jarho P. 2004. Journal of chromatography b: analytical technologies in the biomedical and life sciences
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat
Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Järvinen T, Männistö PT. 2003. Journal of pharmacology and experimental therapeutics

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Marko Lehtonen

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Unraveled cancer cell survival-associated amino acid metabolism of HepG2 cells altered by Thai rat-tailed radish microgreen extract examined by untargeted LC-MS/MS analysis

Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes

Associations of gestational anxiety and depression with neonatal hair steroid levels

Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Fasting plasma metabolites reflecting meat consumption and their associations with incident type 2 diabetes in two Swedish cohorts

Metabolic changes in response to varying whole-grain wheat and rye intake

Metabolic signatures of metabolic dysfunction-associated steatotic liver disease in severely obese patients

Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function

Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson's Disease

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity

Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance

The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

The metabolic response of HepG2 cells to extracellular vesicles derived from Raphanus sativus L. var. caudatus Alef microgreens probed by chemometrics-assisted LC-MS/MS analysis

Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study

Altering distribution profile of palbociclib by its prodrugs

Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy

Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth

Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis

Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy

Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome

Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep

Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation

Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Caffeine content in newborn hair correlates with maternal dietary intake

Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up

Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

Metabolic alterations in Parkinson's disease astrocytes

Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone

Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine

Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure

Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study

Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835

In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)

Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia