Marko Lehtonen
Associate Professor
Research Director
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 355 2250
I specialize in mass spectrometry–based metabolomics and pharmaceutical analytical chemistry, with over 25 years of experience in analytical method development and research infrastructure leadership.
My research focuses on analytical chemistry in life sciences, with a particular emphasis on metabolomics, lipidomics, and LC‑MS and GC‑MS methodologies. My research interests include metabolic liver disease (MASLD), central nervous system (CNS)–related research, obesity, and early-life development. My aim is to develop and apply advanced analytical solutions to better understand biochemical processes and to support drug discovery and translational research.
I serve as Group Leader of the Pharmaceutical Analytics and Mass Spectrometry group at the School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland. In addition, I act as Head of the LC‑MS Metabolomics Center at Biocenter Kuopio, where I oversee research infrastructure and provide analytical services across the full workflow, from study design to data interpretation. My work also covers pharmaceutical analytical chemistry, particularly method development and validation in accordance with regulatory requirements.
My goal is to bridge advanced analytical chemistry with practical applications in biomedical and pharmaceutical research, enabling the generation of high-quality and reliable data to support scientific discovery.
Research groups
-
Analytical Unit of the School of Pharmacy 27.02.2020 - -
LC-MS metabolomics center 01.09.2023 - -
Microplastic research and technology 01.09.2016 -
Projects
Publications
153/153 items-
IFNγ alters the aberrant phenotype of α-synuclein–treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons
Niskanen, Jonna; Hakosalo, Vili; Hämäläinen, Wilhelmiina; Kälvälä, Sara; Hyvönen, Mervi T; Zhang, Yinjia; Luk, Kelvin C; Koistinaho, Jari; Lehtonen, Marko; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2026, Neuroscience, 603, 201-213. A1 Journal article (refereed), original research -
Metabolic changes in human plasma samples among workers exposed to diisocyanate products
Sunnarborg, Katriina; Verdonck, Jelle; Poels, Katrien; Godderis, Lode; Porras, Simo P.; Lehtonen, Marko; Rysä, Jaana; Kärkkäinen, Olli; Santonen, Tiina, 2026, Food and chemical toxicology, [Epub ahead of print 28 May 2026 ], 116183. A1 Journal article (refereed), original research -
Metabolomic insights: LC–MS profiling of human placental tissue from SSRI-treated pregnancies
Itkonen, Anna; Kärkkäinen, Olli; Lehtonen, Marko; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2026, European journal of medical research, 31, 258. A1 Journal article (refereed), original research -
Plasma metabolomics and red blood cell fatty acid profiles in adolescent mental health
Piironen, Aino Kaisa; Afonin, Alexey M; Zarei, Iman; Koistinen, Ville; Lehtonen, Marko; Hämäläinen, Venla; Sala-Vila, Aleix; Lázaro, Iolanda; Julvez, Jordi; van Kamp, Irene; Kanninen, Katja M, 2026, Comprehensive psychoneuroendocrinology, 26, 100347. A1 Journal article (refereed), original research -
Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2025, Basic and clinical pharmacology and toxicology, 136, 5, 1-11. A1 Journal article (refereed), original research -
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research -
Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry
Zarei, Iman; Babu, Ambrin Farizah; Koistinen, Ville M; Tuomainen, Marjo; Kårlund, Anna; Haikonen, Retu; Lehtonen, Marko; Hanhineva, Kati, 2025, Mass spectrometry reviews, 45, 1, 107-119. A2 Review article, Literature review, Systematic review -
Blueprint of the distinct metabolite profiles of healthy pig heart chambers
Haikonen, Retu; Meuronen, Topi; Koistinen, Ville; Kärkkäinen, Olli; Tuomainen, Tomi; Solano-Aguilar, Gloria I; Urban, Joseph F; Lehtonen, Marko; Tavi, Pasi; Hanhineva, Kati, 2025, Journal of molecular and cellular cardiology plus, 13, 100462. A1 Journal article (refereed), original research -
Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells
Wallén, E.; Rämö, K.; Vehviläinen, J.; Sokka, J.; Lehtonen, M.; Otonkoski, T.; Trokovic, R.; Auvinen, P.; Kärkkäinen, O.; Kaminen-Ahola, N, 2025, Disease models and mechanisms, 18, 6, dmm052150. A1 Journal article (refereed), original research -
Evaluation of the quality of the fixed-dose triple combination dispersible tablet for HIV-positive paediatric population after the continuous direct compression and batch manufacturing techniques
Komulainen, Eelis; Kotlolo, Mpho; Kilpeläinen, Tuomas; Komane, Baatile; Ketolainen, Jarkko; Katerere, David R; Lehtonen, Marko; Pajula, Katja; Korhonen, Ossi, 2025, European journal of pharmaceutical sciences, 214, 107299. A1 Journal article (refereed), original research
