
MIKKO HILTUNEN
Professori
Kudos- ja solubiologian professori
Yhteystiedot
Organisaatio
Lääketieteen laitos, Biolääketiede
Sähköposti
mikko.hiltunen@uef.fi
Puhelin
040 355 2014
Tutkimusryhmät
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Alzheimerin taudin molekyyligenetiikka
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Clinical Alzheimer Research
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GenomMed
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Itä-Suomen Genomikeskus
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Neuro-Innovation
Julkaisut
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Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko. 2021. iNPH - the mystery resolving Embo molecular medicine 13 3: e13720. 2021
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Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus European journal of neurology 2021; 28 2: 389-400. 2020
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Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Produ. 2020. A structural variation reference for medical and population genetics Nature 581 7809: 444-451. 2020
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Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals Nature communications 11: 2523. 2020
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Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco AS; Merchant, Kalpana M; Genome Aggregation Database Production Team; Genome Aggregation Database Co. 2020. The effect of LRRK2 loss-of-function variants in humans Nature medicine 26: 869-877. 2020
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Wang, Qingbo; Pierce-Hoffman, Emma; Cumings, Beryl B; Alföldi, Jessica; Francioli, Laurent C; Gauthier, Laura D; Hill, Andrew J; O'Donnell-Luria, Anne H; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes Nature communications 11: 2539. 2020
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Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian. 2020. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions Molecular neurodegeneration 15 1: 52. 2020
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Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members Fluids and barriers of the cns 17: 57. 2020
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Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. 2020. Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Molecular neurodegeneration 15: 66. 2020
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Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa. 2020. BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Frontiers in neurology 11: 550140. 2020
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Minikel, Eric Vallabh; Karczewski, Konrad J; Martin, Hilary C; Cummings, Beryl B; Whiffin, Nicola; Rhodes, Daniel; Alföldi, Jessica; Trembath, Richard C; van Heel, David A; Daly, Mark J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber, Stuart L; MacArthur, Daniel G [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Evaluating drug targets through human loss-of-function genetic variation Nature 581 7809: 459-464. 2020
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Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Cells 9 11: 2482. 2020
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Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. The role of polygenic risk and susceptibility genes in breast cancer over the course of life Nature communications 11 1: 6383. 2020
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Luukkainen, L; Huttula, S; Väyrynen, H; Helisalmi, S; Kytövuori, L; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2020. Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Journal of Alzheimer's disease 76 3: 955-965. 2020
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Karczewski, Konrad J; Francioli, Laurent C; Tiao, Grace; Cummings, Beryl B; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L; Laricchia, Kristen M; Ganna, Andre; Birnbaum, Daniel P; Gauthier, Laura D; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M; Seaby, Eleanor G; Kosmicki, Jack A; Walters, Raymond K; et al.; Genome Aggregation Dat. 2020. The mutational constraint spectrum quantified from variation in 141,456 humans Nature 581 7809: 434-443. 2020
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Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease. Journal of Alzheimer's disease 74 1: 277-286. 2020
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Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anais-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Chécler, Frédéric; Farinelli, Mélissa; Delay, Charlotte; et.al.. 2020. Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner Molecular psychiatry [Published: 03 November 2020]: 1-16. 2020
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Cummings, Beryl B; Karczewski, Konrad J; Kosmicki, Jack A; Seaby, Eleanor G; Watts, Nicholas A; Singer-Berk, Moriel; Mudge, Jonathan M; Karjalainen, Juha; Satterstrom, F Kyle; O'Donnell-Luria, Anne H; Poterba, Timothy; Seed, Cotton; Solomonson, Matthew; Alföldi, Jessica; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Daly, Mark J; MacArthur, Daniel G; et al. [. 2020. Transcript expression-aware annotation improves rare variant interpretation Nature 581 7809: 452-458. 2020
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Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019
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Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen,. 2019. Genetic architecture of human plasma lipidome and its link to cardiovascular disease Nature communications 10: 4329. 2019
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Sartori, M; Mendes, T; Desai, S; Lasorsa, A; Herledan, A; Malmanche, N; Mäkinen, P; Marttinen, M; Malki, I; Chapuis, J; Flaig, A; Vreulx, AC; Ciancia, M; Amouyel, P; Leroux, F; Déprez, B; Cantrelle, FX; Maréchal, D; Pradier, L; Hiltunen, M; et al.. 2019. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation Acta neuropathologica 138 4: 631-652. 2019
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Rostalski, Hannah; Leskelä, Stina; Huber, Nadine; Katisko, Kasper; Cajanus, Antti; Solje, Eino; Marttinen, Mikael; Natunen, Teemu; Remes, Anne M; Hiltunen, Mikko; Haapasalo, Annakaisa. 2019. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Frontiers in neuroscience 13: 486. 2019
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Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. [11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus Journal of Alzheimer's disease 67 4: 1343-1351. 2019
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Moradi, E; Marttinen, M; Häkkinen, T; Hiltunen, M; Nykter, M. 2019. Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease Neurobiology of aging 84: 98-108. 2019
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Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 71 4: 1233-1243. 2019
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Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2019. Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 69 3: 775-782. 2019
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Leskelä, S; Huber, N; Rostalski, H; Natunen, T; Remes, AM; Takalo, M; Hiltunen, M; Haapasalo, A. 2019. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Cells 8 10: 1233. 2019
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Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A. 2019. Using online game-based platforms to improve student performance and engagement in histology teaching BMC Medical Education 19 1: 273. 2019
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Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nature genetics 51 3: 414-430. 2019
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Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Dementia and geriatric cognitive disorders 47 1-2: 91-103. 2019
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Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Journal of Alzheimer's disease 72 1: 127-137. 2019
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Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019
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Gabbouj, Sami; Ryhanen, Simo; Marttinen, Mikael; Wittrahm, Rebekka; Takalo, Mari; Kemppainen, Susanna; Martiskainen, Henna; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko; Natunen, Teemu. 2019. Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway Frontiers in neuroscience 13: 629. 2019
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Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito Duodecim 135 3: 265-273. 2019
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Marttinen, M; Paananen, J; Neme, A; Mitra, V; Takalo, M; Natunen, T; Paldanius, KMA; Mäkinen, P; Bremang, M; Kurki, MI; Rauramaa, T; Leinonen, V; Soininen, H; Haapasalo, A; Pike, I; Hiltunen, M. 2018. A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology Neurobiology of disease 2019; 124: 454-468. 2018
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Vanhala, V; Junkkari, A; Korhonen, VE; Kurki, MI; Hiltunen, M; Rauramaa, T;, Nerg, O;, Koivisto, AM; Remes, AM; Perälä, J; Suvisaari, J; Lehto, S; Viinamäki, H; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus Neurosurgery 2019; 84 4: 883-889. 2018
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Tanila, Heikki; Hiltunen, Mikko; Myllykangas, Liisa. 2018. Alzheimerin taudin patofysiologia - mitä uutta? Duodecim 134 24: 2511-2518. 2018
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Sulkava, S; Muggalla, P; Sulkava, R; Ollila, HM; Peuralinna, T; Myllykangas, L; Kaivola, K; Stone, DJ; Traynor, BJ; Renton, AE; Rivera, AM; Helisalmi, S; Soininen, H; Polvikoski , T; Hiltunen, M; Tienari, PJ; Huttunen, HJ; Paunio, T. 2018. Melatonin receptor type 1A gene linked to Alzheimer's disease in old age Sleep 41 7: 1-10. 2018
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Sarajärvi, T; Jäntti, M; Paldanius, KMA; Natunen, T; Wu, JC; Mäkinen, P; Tarvainen, I; Tuominen, RK; Talman, V; Hiltunen, M. 2018. Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations Neuropharmacology 141: 76-88. 2018
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Pyykkö, OT; Nerg, O; Niskasaari, HM; Niskasaari, T; Koivisto, AM; Hiltunen, M; Pihlajamäki, J; Rauramaa, T; Kojoukhova, M; Alafuzoff, I; Soininen, H; Jääskeläinen, JE; Leinonen, V. 2018. Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus. WORLD NEUROSURGERY 112: e624-e631. 2018
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Peloso, GM; van der Lee, SJ; International Genomics of Alzheimer's Project (IGAP); Destefano, AL; Seshardi, S; et al. (incl. Hiltunen, Mikko; Haapasalo, Annakaisa; Helisalmi, Seppo; Koivisto, Anne). 2018. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 10: 595-598. 2018
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Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease Frontiers in neurology 12: 963. 2018
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Leinonen, V; Rauramaa, T; Johansson, J; Bottelbergs, A; Tesseur, I; van der Ark, P; Pemberton, D; Koivisto, AM; Jääskeläinen, JE; Hiltunen, M; Herukka, SK; Blennow, K; Zetterberg, H; Jokinen, P; Rokka, J; Helin, S; Haaparanta-Solin, M; Solin, O; Okamura, N; Kolb, HC; et al.. 2018. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-ß Plaques and Tau in Brain Biopsies Journal of Alzheimer's Disease 64 1: 171-179. 2018
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Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Decreased plasma C-reactive protein levels in APOE E 4 allele carriers Annals of Clinical and Translational Neurology 5 10: 1229-1240. 2018
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Leskelä, S; Takalo, M; Marttinen, M; Huber, N; Paananen, J; Mitra, V; Rauramaa, T; Mäkinen, P; Leinonen, V; Soininen, H; Pike, I; Remes, AM; Hiltunen, M; Haapasalo, A. 2018. Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples Journal of Alzheimer's disease 62 1: 269-278. 2018
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Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients Acta neuropathologica communications 6: 102. 2018
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Korhonen, VE; Helisalmi, S; Jokinen, A; Jokinen, I; Lehtola, JM; Oinas, M; Lönnrot, K; Avellan, C; Kotkansalo, A; Frantzen, J; Rinne, J; Ronkainen, A; Kauppinen, M; Junkkari, A; Hiltunen, M; Soininen, H; Kurki, M; Jääskeläinen, JE; Koivisto, AM; Sato, H; et al. 2018. Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH Neurology : Genetics 4 6: e291. 2018
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Haapasalo, Annakaisa; Hiltunen, Mikko. 2018. A report from the 8th Kuopio Alzheimer Symposium Neurodegenerative disease management 8 5: 289-299. 2018
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Haapala, Eero A; Paananen, Jussi; Hiltunen, Mikko; Lakka, Timo A. 2018. Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study Journal of Alzheimer's Disease 64 2: 587-595. 2018
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Gabbouj, S; Natunen, T; Koivisto, H; Jokivarsi, K; Takalo, M; Marttinen, M; Wittrahm, R; Kemppainen, S; Naderi, R; Posado-Fernández, A; Ryhänen, S; Mäkinen, P; Paldanius, KMA; Doria, G; Poutiainen, P; Flores, O; Haapasalo, A; Tanila, H; Hiltunen, M. 2018. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice NEUROBIOLOGY OF AGING 2019; 75: 98-108. 2018
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de Matos, MR; Ferreira, C; Herukka, SK; Soininen, H; Janeiro, A; Santana, I; Baldeiras, I; Almeida, MR; Lleó, A; Dols-Icardo, O; Alcolea, D; Benussi, L; Binetti, G; Paterlini, A; Ghidoni, R; Nacmias, B; Meulenbroek, O; van Waalwijk van Doorn, LJC; Kuiperij, HB; Hausner, L; et al. 2018. Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers Journal of Alzheimer's Disease 66 2: 639-652. 2018
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Bis, JC; Jian, X; Kunkle, BW; Chen, Y; Hamilton-Nelson, KL; Bush, WS; Salerno, WJ; Lancour, D; Ma, Y; Renton, AE; Marcora, E; Farrell, JJ; Zhao, Y; Qu, L; Ahmad, S; Amin, N; Amouyel, P; Beecham, GW; Below, JE; Campion, D; et al [ Incl Helisalmi, Seppo; HIltunen, Mikko; Remes, Anne; Soininen, Hilkka]. 2018. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation Molecular psychiatry [Published: 14 August 2018]: 1-17. 2018
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Ylönen Susanna, Siitonen Ari, Nalls Michael A, Ylikotila Pauli, Autere Jaana, Eerola-Rautio Johanna, Gibbs Raphael, Hiltunen Mikko, Tienari Pentti J, Soininen Hilkka, Singleton Andrew B, Majamaa Kari. 2017. Genetic risk factors in Finnish patients with Parkinson's disease. PARKINSONISM & RELATED DISORDERS 45: 39-43. 2017
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Takalo Mari, Natunen Teemu, Leskelä Stina, Paldanius Kaisa MA, Soininen Hilkka, Hiltunen MIkko, Haapasalo Annakaisa. 2017. New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1 Journal of Alzheimer's disease & Parkinsonism 7 5: 365. 2017
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Suhonen N-M, Haanpää RM, Korhonen V, Jokelainen J, Pitkäniemi A, Heikkinen A-L, Krüger J, Hartikainen P, Helisalmi S, Hiltunen M, Hänninen T, Remes AM. 2017. Neuropsychological Profile in the C9ORF72 Associated Behavioral Variant Frontotemporal Dementia. Journal of Alzheimer's Disease 58 2: 479-489. 2017
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Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017
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Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD et al.. 2017. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. PLOS ONE 12 10: e0185777. 2017
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Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADG. 2017. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. NATURE GENETICS 49 9: 1373-1384. 2017
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Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017
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Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017
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Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers. ANNALS OF NEUROLOGY 82 1: 128-132. 2017
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Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment PLOS ONE 12 12: e0188880. 2017
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Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 60 3: 1077-1085. 2017
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Adam A, Robison J, Lu J, Jose R, Hiltunen M, Huovinen J, Helisalmi S, Paananen J, Koivisto AM, Remes AM, Soininen H, Kurki M, Jääskeläinen JE, Leinonen V et al. 2017. Abstracts from Hydrocephalus 2016. Fluids and barriers of the CNS 14: 15. 2017
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Marttila Maria, Kytövuori Laura, Helisalmi Seppo, Kallio Mika, Laitinen Marjo, Hiltunen Mikko, Kärppä Mikko, Majamaa Kari. 2017. Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study. NEUROEPIDEMIOLOGY 49 1-2: 34-39. 2017
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Russell Claire L, Mitra Vikram, Hansson Karl, Blennow Kaj, Gobom Johan, Zetterberg Henrik, Hiltunen Mikko, Ward Malcolm, Pike Ian. 2016. Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates. Journal of Alzheimer's Disease 2017; 55 1: 303-313. 2016
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Yan Xu, Nykänen Niko-Petteri, Brunello Cecilia A, Haapasalo Annakaisa, Hiltunen Mikko, Uronen Riikka-Liisa, Huttunen Henri J. 2016. FRMD4A-cytohesin signaling modulates the cellular release of tau. JOURNAL OF CELL SCIENCE 129 10: 2003-2015. 2016
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Solje Eino, Riipinen Pirkko, Helisalmi Seppo, Särkioja Terttu, Laitinen Marjo, Hiltunen Mikko, Hakko Helinä, Remes Anne M. 2016. The role of the FTD-ALS associated C9orf72 expansion in suicide victims. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration [epub ahead of print 8 Jul 2016]: 1-4. 2016
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Solje Eino, Miettunen Jouko, Marttila Riikka, Helisalmi Seppo, Laitinen Marjo, Koivumaa-Honkanen Heli, Isohanni Matti, Hiltunen Mikko, Jääskeläinen Erika, Remes Anne M. 2016. The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966. PSYCHIATRIC GENETICS 26 2: 92-94. 2016
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Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus Acta neurochirurgica 158 12: 2311-2319. 2016
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Rilla Kirsi, Hiltunen Mikko. 2016. Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina. BestPractice Psykiatria/neurologia: lääketieteen asiantuntijoiden ammattilehti 4 16 (Lokakuu 2016): 11-13. 2016
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Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's Disease 2017; 55 3: 995-1003. 2016
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Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. JOURNAL OF CELL SCIENCE 129: 2224-2238. 2016
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Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Familial idiopathic normal pressure hydrocephalus. JOURNAL OF THE NEUROLOGICAL SCIENCES 368: 11-18. 2016
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Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. 2016. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. MOLECULAR PSYCHIATRY [Epub ahead of print]: 1-10. 2016
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Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. PROGRESS IN NEUROBIOLOGY epub ahead of print 19 May 2015. 2015
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Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. EPILEPSY RESEARCH 112: 43-55. 2015
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Steinberg Stacy, Stefansson Hreinn, Jonsson Thorlakur, Johannsdottir Hrefna, Ingason Andres, Helgason Hannes, Sulem Patrick, Magnusson Olafur Th, Gudjonsson Sigurjon A, Unnsteinsdottir Unnur, Kong Augustine, Helisalmi Seppo, Soininen Hilkka, Lah James J, DemGene, Aarsland Dag, Fladby Tormod, Ulstein Ingun D, Djurovic Srdjan, Sando Sigrid B (incl. Hiltunen Mikko). 2015. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. NATURE GENETICS 47 5: 445-447. 2015
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Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease. Journal of Alzheimer's Disease 48 2: 507-516. 2015
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Salminen Antero, Jouhten Paula, Sarajärvi Timo, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease. NEUROCHEMISTRY INTERNATIONAL 92 January 2016: 13-24. 2015
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Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. Journal of Alzheimer's Disease 46 1: 261-269. 2015
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Remes Anne, Hiltunen Mikko, Castrén Maija, Pöyhönen Minna. 2015. Muistisairauksien genetiikka ja perinnölliset muistisairaudet. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen (toim.) Muistisairaudet. KUSTANNUS OY DUODECIM. s. 194-. 2015
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Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 2016; 85: 187-205. 2015
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Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Synaptic dysfunction and septin protein family members in neurodegenerative diseases. MOLECULAR NEURODEGENERATION 10 16: 12 p. 2015
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Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach. Journal of Alzheimer's Disease 43 2: 565-573. 2015
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Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's Disease 48 4: 959-968. 2015
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Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA et al (incl. Hilkka Soininen and Mikko Hiltunen). 2015. A novel Alzheimer disease locus located near the gene encoding tau protein. MOLECULAR PSYCHIATRY 2016; 21 1: 108-117. 2015
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Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014
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Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. AGEING RESEARCH REVIEWS 16: 45-65. 2014
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Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. CELLULAR SIGNALLING 26: 1598-1603. 2014
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Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2014. Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences. Sleep and Breathing 18 3: 641-647. 2014
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Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. JOURNAL OF MOLECULAR MEDICINE -: -. 2014
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Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus. PLOS ONE [ONLINE] 9 3; e91974: 1-10. 2014
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Jones L, Lambert J, Wang L, Choi S, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards A, Bellenguez C, Ibrahim-Verbaas CA, Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, ..., Soininen H, et al., (International Genomics of Alzheimer's Disease Consortium (IGAP); International Genomics of Alzheimer's Disease Consortium IGAP). 2014. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia 2014 Available online 2014 Dec 20: 1-14. 2014
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Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models. NEUROBIOLOGY OF AGING 36 2: 1221.e15-1221.e28. 2014
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Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology. PLOS ONE [ONLINE] 3 9: e93717: 1-8. 2014
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Kurki MI, Gaál EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, van 't Hof FN, von Und Zu Fraunberg M, Helisalmi S, Hiltunen M, Lehto H2, Laakso A, Kivisaari R, Koivisto T, Ronkainen A, Rinne J, Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, Aromaa A, Perola M, Lehtimäki T, Raitakari OT, Salomaa V, Gunel M, Dermitzakis ET, Ruigrok YM, Rinkel GJ, Niemelä M, Hernesniemi J, Ripatti S, de B. 2014. High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLOS GENETICS [ONLINE) 10 1: e1004134. 2014
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Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. ADAMTS9 locus associates with increased risk of wet AMD. ACTA OPHTHALMOLOGICA 2014: 1. 2014
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Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients. NEURODEGENERATIVE DISEASES 14 4 (Online First Articles): 204-208. 2014
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Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert J-C, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA et.al.. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLOS ONE [ONLINE] 9 6: e94661. 2014
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Lipsanen Anu, Parkkinen Saara, Khabbal Joonas, Mäkinen Petra, Peräniemi Sirpa, Hiltunen Mikko, Jolkkonen Jukka. 2014. KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. NEUROSCIENCE LETTERS 580: 173-177. 2014
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Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease. PLOS ONE [ONLINE] 8 11: e80700. 2013
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Viswanathan J, Haapasalo A, Kurkinen KMA, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells. BIOCHEMISTRY 52: 3899-3912. 2013
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Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. 2013. Protein aggregation and degradation mechanisms in neurodegenerative diseases. American Journal of Neurodegenerative Disease 2 1: 1-14. 2013
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Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KMA, Tanzi RE, Soininen H, Hiltunen M. 2013. Targeting ubiquilin-1 in Alzheimer's disease. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 795-810. 2013
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Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS -: -. 2013
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Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. PROGRESS IN NEUROBIOLOGY 106-107: 33-54. 2013
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Rubio-Moscardo Fanny, Seto-Salvia Nuria, Pera Marta, Bosch-Morato Monica, Plata Christina, Belbin Olivia, Gene Gemma, Dols-Icardo Oriol, Ingelsson Martin, Helisalmi Seppo, Soininen Hilkka, Hiltunen Mikko, Giedraitis Vilmantas, Lannfelt Lars, Frank Ana, Bullido Ma Jesus, Combarros Onofre, Sanchez-Juan Pascual et.al.. 2013. Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's Disease patients alter calcium homeostasis. PLOS ONE [ONLINE] 8 9: e74203. 2013
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Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. 2013. γ-Secretase Components as Predictors of Breast Cancer Outcome. PLOS ONE [ONLINE] 8 11: e79249, 1-13. 2013
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Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2013. The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea. Journal of Sleep Research 22 6: 663-669. 2013
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Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease. Journal of Alzheimer's Disease 37: 217-232. 2013
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Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 781-794. 2013
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Lipsanen A, Kalesnykas G, Pro-Sistiaga P, Hiltunen M, Vanninen R, Bernaudin M, Touzani O, Jolkkonen J. 2013. Lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates. EXPERIMENTAL NEUROLOGY 248: 224-227. 2013
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Lipsanen A, Flunkert S, Kuptsova K, Hiltunen M, Windisch M, Hutter-Paier B, Jolkkonen J. 2013. Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. PLOS ONE [ONLINE] 8 3: e60235. 2013
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Lambert JC,Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, ... Soininen H, ... Hiltunen M et al.. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. NATURE GENETICS Dec; 45 (12): 1452-8. 2013
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Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients. Journal of Alzheimer's Disease 33: 23-27. 2013
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Hiltunen M, Haapasalo A, Soininen H. 2013. Alzheimern taudin uudet riskigeenit - tautia ennakoivat biomarkkerit?. DUODECIM 129: 583-588. 2013
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Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLOS ONE [ONLINE] 8 4: e59676. 2013
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Viswanathan J, Soininen H, Hiltunen M. 2012. Genetics of Alzheimer's disease. Teoksessa: Gauthier S, Rosa-Neto P (toim.), Advances in Alzheimer's Disease Management. ss. 2-9. 2012
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Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko. 2012. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 24: 360-370. 2012
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Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings NEUROLOGY 78: 1568-1575. 2012
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Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16 11: 2754-2767. 2012
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Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 96: 87-95. 2012
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Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 83 11: 1119-1124. 2012
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Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease Journal of Alzheimer's Disease 28: 553-559. 2012
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Huumonen Katriina, Immonen Hanna-Kaisa, Baverstock Keith, Hiltunen Mikko, Korkalainen Merja, Lahtinen Tapani, Parviainen Juha, Viluksela Matti, Wong Garry, Naarala Jonne, Juutilainen Jukka. 2012. Radiation-induced genomic instability in Caenorhabditis elegans. MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 748 748: 36-41. 2012
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Hiltunen Mikko, Jolkkonen Jukka. 2012. Letter by Hiltunen and Jolkkonen Regarding Article, "Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?". STROKE 43: e97. 2012
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Hiltunen Mikko, Hallikainen Merja, Haapasalo Annakaisa, Soininen Hilkka. 2012. Alzheimerin taudin perustutkimuksesta uusiin lääkehoitoihin [with English Summary: From basic research towards novel therapies in Alzheimer's disease] DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 1: 25-31. 2012
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Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16: 1206-1222. 2012
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Hiltunen M, Jolkkonen J. 2012. Secondary neurodegeneration in remote regions after focal cerebral infarction: A new target for Stroke Management STROKE 43: e96. 2012
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Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C et al.. 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. MOLECULAR PSYCHIATRY -: -. 2012
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Lipsanen Anu, Hiltunen Mikko, Jolkkonen Jukka. 2011. Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 99: 468-474. 2011
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Viswanathan Jayashree, Haapasalo Annakaisa, Böttcher Claudia, Miettinen Riitta, Kurkinen Kaisa MA, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi RE, Hiltunen Mikko. 2011. Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12: 330-348. 2011
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Turunen Mari, Vepsäläinen Saila, Mäkinen Petra, Helisalmi Seppo, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2011. No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease. NEUROBIOLOGY OF AGING 32: 547.e7-547.e9. 2011
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Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M & Soininen H.. 2011. Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Negative results. NEUROBIOLOGY OF AGING 32: 546.e7-546.e9. 2011
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Sarajärvi Timo, Tuusa Jussi T, Haapasalo Annakaisa, Lackman Jarkko T, Sormunen Raija, Helisalmi Seppo, Roehr Johannes T, Parrado Antonio R, Mäkinen Petra, Bertram Lars, Soininen Hilkka, Tanzi Rudolph E, Petäjä-Repo Ulla E, Hiltunen Mikko. 2011. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. MOLECULAR AND CELLULAR BIOLOGY 31 11: 2326-2340. 2011
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Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 34: 3-11. 2011
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Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease PROGRESS IN NEUROBIOLOGY 96: 87-95. 2011
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Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. AMP-activated protein kinase: a potential player in Alzheimer's disease JOURNAL OF NEUROCHEMISTRY 118: 460-474. 2011
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Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri F, Delepine M et al.. 2011. Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations NEUROBIOLOGY OF AGING 32: 756.e11-756.e15. 2011
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Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fievet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S et al.. 2011. APOE and Alzheimer disease: a major gene with semi-dominant inheritance MOLECULAR PSYCHIATRY 16: 903-907. 2011
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Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J et al.. 2011. Common variants at ABCA7,MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease NATURE GENETICS 43 5: 429-435. 2011
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Hiltunen M, Jolkkonen J. 2011. Complex pathology in the thalamus following cerebral ischemia: Song JL, Thalamus: Anatomy, Functions and Disorders. 83-98. 2011
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Hiltunen M, Bertram L, Saunders AJ. 2011. Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease International Journal of Alzheimer's Disease ID 925362: 1-2. 2011
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Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 31: 1119-1132. 2011
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Haapasalo A, Viswanathan J, Kurkinen KMA, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. 2011. Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Communicative & Integrative Biology 4 4: 428-432. 2011
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Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Age-related macular degeneration (AMD): Alzheimer's Disease in the eye Journal of Alzheimer's Disease 24: 615-631. 2011
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Pelkonen A, Hiltunen M, Kiianmaa K & Yavich L. 2010. Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference. JOURNAL OF NEUROCHEMISTRY 114 4: 1168-1176. 2010
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Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. An association study of 21 potential Alzheimer's disease risk genes in a Finnish population. Journal of Alzheimer's Disease 21 3: 763-767. 2010
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Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 93: 99-110. 2010
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Giedraitis V, Glaser A, Sarajärvi T, Brundin RM, Degerman Gunnarsson M, Schjeide BM, Tanzi RE, Helisalmi S et al. 2010. CALHM1 P86L polymorphism does not alter amyloid-beeta or tau in cerebrospinal fluid. NEUROSCIENCE LETTERS 469: 265-267. 2010
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Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H & Alafuzoff I. 2010. Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 36: 41-54. 2010
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Lambert JC, Sleegers K, Gonzalez-Perez A, Ingelsson M, Beecham GW, Hiltunen M et al. 2010. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's Disease 22 1: 247-255. 2010
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Karjalainen Reijo, Hiltunen Mikko, Vepsäläinen Saila, Törrönen Riitta, Saviranta Niina, Hilz Hauke, Bildstein Marie, McDougall Gordon, Stewart Derek, Mattila Pirjo, Tanila Heikki. 2010. Blackcurrant (Ribes nigrum L.) neuroprotective potential: New results from the "BrainHealthFood" project, XXV International conference on polyphenols: Polyphenols communications 2010 volume 1. 26-27. 2010
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Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I. 2010. Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain. Journal of Alzheimer's Disease 20: 1015-1028. 2010
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Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M, Soininen H, Hiltunen M. 2009. Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 284 49: 34433-34443. 2009
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Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M, Soininen H, Hiltunen M, Helisalmi S. 2009. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. AMERICAN JOURNAL OF MEDICAL GENETICS. PART B. NEUROPSYCHIATRIC GENETICS 150B 5: 747-750. 2009
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Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Combined risk effects of IDE and NEP gene variants on Alzheimer disease. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 80: 1268-1270. 2009
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Helisalmi S, Väkevä A, Hiltunen M, Soininen H, Soininen H, Helisalmi S. 2009. Flanking markers of cyntation C (CST3) gene do not show association with Alzheimer's disease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 27: 318-321. 2009
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Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE, Hiltunen M, Soininen H. 2009. Effects of ubiquillin 1 on the unfolded protein response. JOURNAL OF MOLECULAR NEUROSCIENCE 38: 19-30. 2009
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Lambert JC, Heath S, Even G..., Hiltunen M, Combarros O..., Helisalmi S, Porcellini E..., Licastro F, Soininen H, Ritchie K..., Amouyel P, Hiltunen M, Helisalmi S, Soininen H. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. NATURE GENETICS 41 10: 1047-1048. 2009
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Hiltunen M, van Groen T, Jolkkonen J. 2009. Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: Evidence from experimental studies. Journal of Alzheimer's Disease 18: 401-412. 2009
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Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 35: 103-113. 2009
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Bertram L, Schjeide BMM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE, Hiltunen M, Soininen H. 2008. No association between CALHM1 and Alzheimers's disease risk. CELL 135: 993-994. 2008
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Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M, Helisalmi S, Soininen H, Hiltunen M. 2008. Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease. EUROPEAN JOURNAL OF HUMAN GENETICS 16: 171-175. 2008
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Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease. NEUROSCIENCE LETTERS 441 2: 233-236. 2008
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Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease. JOURNAL OF NEUROLOGY 255: 668-673. 2008
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Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Genetic study evaluating LDLR polymorphisms and Alzheimer's disease NEUROBIOLOGY OF AGING 29: 848-855. 2008
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Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28: 263-268. 2008
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Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology. NEUROSCIENCE LETTERS 438: 216-220. 2008
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Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population JOURNAL OF MEDICAL GENETICS 44: 606-608. 2007
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Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients. JOURNAL OF NEUROLOGY 254: 1504-1508. 2007
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Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang S-H, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. 2007. Depletion of GGA3 stabilizes bace and enhances [beta]-secretase activity. NEURON 54 5: 721-737. 2007
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Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. The association study between DHCR24 polymorphisms and Alzheimer's disease. AMERICAN JOURNAL OF MEDICAL GENETICS. PART B. NEUROPSYCHIATRIC GENETICS 144B: 906-910. 2007
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Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 24: 146-150. 2007
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Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 26: 1845-1852. 2007
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Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 77: 421-422. 2006
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Hiltunen M, Iivonen S, Soininen H, Hiltunen M, Soininen H. 2006. Aromatase enzyme and Alzheimer¿s disease. MINERVA ENDOCRINOLOGICA 31 1: 61-73. 2006
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Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice NEUROSCIENCE 137: 1143-1152. 2006
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Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006
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Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Adiponectin gene haplotype is associated with preeclampsia. GENETIC TESTING 10 1: 35-39. 2006
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Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia. GYNECOLOGIC AND OBSTETRIC INVESTIGATION 61: 124-127. 2006
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Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 128: 175-179. 2006
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Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P. 2005. Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated alpha-synuclein. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 303-313. 2005
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Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease. JOURNAL OF NEUROLOGY 252: 423-428. 2005
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Turunen P, Puhakka H, Rutanen J, Hiltunen MO, Heikura T, Gruchala M, Ylä-Herttuala S. 2005. Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta ATHEROSCLEROSIS 179 1: 27-33. 2005
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Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. 2005. APP substitutions V715F and L720P alter PS1 conformation and dirrerentially affect Abeta and AICD generation. JOURNAL OF NEUROCHEMISTRY 95: 446-456. 2005
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Rutanen J, Turunen A-M, Teittinen M, Rissanen TT, Heikura T, Koponen JK, Gruchala M, Inkala M, Jauhiainen S, Hiltunen MO, Turunen MP, Stacker SA, Achen MG, Ylä-Herttuala S. 2005. Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism. GENE THERAPY 12: 980-987. 2005
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Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. 2005. Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. MOLECULAR HUMAN REPRODUCTION 11 6: 437-440. 2005
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Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women EUROPEAN JOURNAL OF HUMAN GENETICS 13: 1000-1006. 2005
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Chaudhuri JD, Hiltunen M, Nykänen M, Ylä-Herttuala S, Soininen H, Miettinen R, Hiltunen M, Soininen H. 2005. Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods. NEUROSCIENCE 131: 557-566. 2005
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Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. 2005. Family-based association between Alzheimer¿s disease and variants in UBQLN1. NEW ENGLAND JOURNAL OF MEDICINE 352 9: 884-894. 2005
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Puhakka HL, Turunen P, Rutanen J, Hiltunen MO, Turunen MP, Ylä-Herttuala S. 2005. Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model. JOURNAL OF VASCULAR RESEARCH 42 5: 361-367. 2005
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Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A, Vepsäläinen S, Hänninen T, Soininen H, Hiltunen M, Iivonen S, Hiltunen M, Soininen H, Helisalmi S, Vepsäläinen S. 2004. Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease. NEUROLOGY 62: 1170-1176. 2004
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Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin C-H, Östman A, Ylä-Herttuala S. 2004. Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits. CIRCULATION 109: 1140-1146. 2004
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Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppänen P, Turunen A-M, Ylä-Herttuala S. 2004. Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vasvular smooth muscle cells. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36 3: 333-341. 2004
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Toivonen S, Romppanen E-L, Hiltunen M, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 11: 540-544. 2004
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Hiltunen M, Helisalmi S, Kivipelto M, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2004. Alzheimerin taudin genetiikka. DUODECIM 120: 2425-2431. 2004
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Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 75: 1746-1748. 2004
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Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Genetic variation in apolipoprotein D and Alzheimer¿s disease. JOURNAL OF NEUROLOGY 251: 951-957. 2004
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Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population. NEUROLOGY 63: 173-175. 2004
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Faisel F, Romppanen E-L, Hiltunen M, Helisalmi S, Laasanen J, Punnonen K, Salonen JT, Heinonen S, Hiltunen M, Helisalmi S. 2004. Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. EUROPEAN JOURNAL OF HUMAN GENETICS 12: 187-191. 2004
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Turunen MP, Hiltunen MO, Ylä-Herttuala S. 2003. Cardiovascular gene therapy. Teoksessa: Rolland A, Sullivan SM (toim.) Pharmaceutical Gene Delivery Systems. Ei jufo-kustantaja/not jufo publisher. s. 345-362. 2003
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Rutanen J, Leppänen P, Tuomisto TT, Rissanen TT, Hiltunen MO, Vajanto I, Niemi M, Häkkinen T, Karkola K, Stacker SA, Achen MG, Alitalo K, Ylä-Herttuala S. 2003. Vascular endothelial growth factor-D expression in human atherosclerotic lesions. CARDIOVASCULAR RESEARCH 59: 971-979. 2003
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Mattila KM, Hiltunen M, Rinne JO, Mannermaa A, Röyttä M, Alafuzoff I, Laippala P, Soininen H, Lehtimäki T. 2003. Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer¿s disease in Finnish patients NEUROSCIENCE LETTERS 337: 61-63. 2003
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Iivonen S, Helisalmi S, Mannermaa A, Alafuzoff I, Lehtovirta M, Soininen H, Hiltunen M. 2003. Heparan sulfate proteoglycan 2 polymorphism in Alzheimer¿s disease and correlation with neuropathology. NEUROSCIENCE LETTERS 352: 146-150. 2003
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Hiltunen MO, Ylä-Herttuala S. 2003. DNA methylation, smooth muscle cells. and atherogenesis. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 23: 1750-1753. 2003
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Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, Rutanen J, Kosma V-M, Mahonen A, Kröger H, Ylä-Herttuala S. 2003. Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB JOURNAL 17: 1147-1149. 2003
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Vajanto I, Rissanen TT, Rutanen J, Hiltunen MO, Tuomisto TT, Arve K, Närvänen O, Manninen H, Räsänen H, Hippeläinen M, Alhava E, Ylä-Herttuala S. 2002. Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ. JOURNAL OF GENE MEDICINE 4: 371-380. 2002
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Turunen MP, Puhakka HL, Koponen JK, Hiltunen MO, Rutanen J, Leppänen O, Turunen A-M, Närvänen A, Newby AC, Baker AH, Ylä-Herttuala S. 2002. Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. MOLECULAR THERAPY 6: 306-312. 2002
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Laasanen J, Heinonen S, Hiltunen M, Mannermaa A, Laakso M. 2002. Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia. EARLY HUMAN DEVELOPMENT 69: 77-82. 2002
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Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 14: 123-127. 2002
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Laasanen J, Romppanen E-L, Hiltunen M, Helisalmi S, Mannermaa A, Punnonen K, Heinonen S. 2002. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia EUROPEAN JOURNAL OF HUMAN GENETICS 10: 569-573. 2002
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Laasanen J, Hiltunen M, Punnonen K, Mannermaa A, Heinonen S. 2002. Fibrinogen and factor VII promoter polymorphism in women with preeclampsia. OBSTETRICS AND GYNECOLOGY 100: 317-20. 2002
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Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M, Leppänen P, Turunen MP, Markkanen JE, Arve K, Alhava E, Kauppinen RA, Ylä-Herttuala S. 2002. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. AMERICAN JOURNAL OF PATHOLOGY 160 4: 1393-1403. 2002
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Korhonen S, Romppanen E-L, Hiltunen M, Mannermaa A, Punnonen K, Hippeläinen M, Heinonen S. 2002. Lack of association between C-850T polymorphism of the gene encoding tumor necrosis factor-alfa and polycystic ovary syndrome. GYNECOLOGICAL ENDOCRINOLOGY 16: 271-274. 2002
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Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. 2002. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. VASCULAR MEDICINE (LONDON) 7: 5-11. 2002
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Hiltunen MO, Tuomisto TT, Niemi M, Bräsen JH, Rissanen TT, Törönen P, Vajanto I, Ylä-Herttuala S. 2002. Changes in gene expression in atherosclerotic plaques analyzed using DNA array. ATHEROSCLEROSIS 165: 23-32. 2002
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Heiskanen J, Romppanen E-L, Hiltunen M, Iivonen S, Mannermaa A, Punnonen K, Heinonen S. 2002. Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 19 5: 220-223. 2002
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Eloranta M-L, Heiskanen JTM, Hiltunen MJ, Mannermaa AJ, Punnonen KRA, Heinonen ST. 2002. Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alfa gene polymorphisms in Finnish women with obstetric cholestasis. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 104: 109-112. 2002
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Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland. EUROPEAN JOURNAL OF NEUROLOGY 9 5: 479-483. 2002
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Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease. NEUROSCIENCE 113 2: 301-310. 2002
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Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland. NEUROLOGY 57: 1663-1668. 2001
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Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin. NEUROGENETICS 3: 171-172. 2001
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Hiltunen M, Soininen H. 2001. Genes, proteins and brain disease. TRENDS IN MOLECULAR MEDICINE 7 9: 382-383. 2001
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Heinonen S, Korhonen S, Hippeläinen M, Hiltunen M, Mannermaa A, Saarikoski S. 2001. Apolipoprotein E alleles in women with polycystic ovary syndrome. FERTILITY AND STERILITY 75 5: 878-880. 2001
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Heiskanen JT, Pirskanen MM, Hiltunen MJ, Mannermaa AJ, Punnonen KR, Heinonen ST. 2001. Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 185: 600-603. 2001
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Heinonen S, Eloranta M-L, Heiskanen J, Punnonen K, Helisalmi S, Mannermaa A, Hiltunen M. 2001. Maternal susceptibility locus for obstetric cholestasis maps to chromosone region 2p13 in finnish patients. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 36: 766-770. 2001
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Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes. GENE THERAPY 8: 784-788. 2001
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Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S. 2000. Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes. JOURNAL OF GENE MEDICINE 2: 52-60. 2000
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Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. 2000. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. HUMAN GENE THERAPY 11: 263-270. 2000
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Hiltunen MO. 2000. Gene Expression in Atherosclerotic Lesions and Therapeutic Strategies Using Gene Transfer. Kuopion yliopiston julkaisuja D. Lääketiede. 2000
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Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods. FASEB JOURNAL 14: 2230-2236. 2000
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Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. 2000. Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta. CIRCULATION 102: 2262-2268. 2000
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Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. 2000. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer. VASCULAR MEDICINE (LONDON) 5: 41-48. 2000
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Hiltunen M. 2000. A Molecular Genetic Study of Factors Involved in Alzheimer¿s Disease. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No. 2000
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Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination? EUROPEAN JOURNAL OF HUMAN GENETICS 8: 259-266. 2000
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Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E. NEUROSCIENCE LETTERS 287: 25-28. 2000
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Airenne KJ, Hiltunen MO, Turunen MP, Turunen A-M, Laitinen OH, Kulomaa MS, Ylä-Herttuala S. 2000. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery. GENE THERAPY 7: 1499-1504. 2000
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Turunen MP, Hiltunen MO, Ylä-Herttuala S. 1999. Gene therapy for angiogenesis, restenosis and related diseases. EXPERIMENTAL GERONTOLOGY 34: 567-574. 1999
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Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. 1999. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes. GENE THERAPY 6: 6-11. 1999
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Turunen M, Hiltunen M, Ylä-Herttuala S. 1999. Geeniterapia ja sen mahdollisuudet verisuonitautien hoidossa. KEMIA-KEMI 26: 186-188. 1999
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Laukkanen MO, Mannermaa S, Hiltunen MO, Aittomäki S, Airenne K, Jänne J, Ylä-Herttuala S. 1999. Local hypomethylation in atherosclerosis found in rabbit ec-sod gene. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2171-2178. 1999
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Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S. 1999. Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment PHARMACOLOGICAL RESEARCH 40 5: 451-457. 1999
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Häkkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Ylä-Herttuala S. 1999. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2909-2917. 1999
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Hiltunen MO, Niemi M, Ylä-Herttuala S. 1999. Functional genomics and DNA array techniques in atherosclerosis research. CURRENT OPINION IN LIPIDOLOGY 10: 515-519. 1999
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Gough PJ, Greaves DR, Suzuki H, Hakkinen T, Hiltunen MO, Turunen M, Ylä-Herttuala S, Kodama T, Gordon S. 1999. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 461-471. 1999
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Hiltunen MO, Turunen MP, Ylä-Herttuala S. 1998. Geeniterapia verisuonitautien hoidossa. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 14 4: 202-206. 1998
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Hiltunen MO, Ylä-Herttuala S. 1998. Kani eläinmallina ateroskleroosin geeniterapiatutkimuksissa. KOEKUKKO. KUOPION YLIOPISTO. VALTAKUNNALLINEN KOE-ELÄINKESKUS 18 2: 28-32. 1998
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Hyttinen J-M, Korhonen V-P, Hiltunen MO, Myöhänen S, Jänne J. 1998. High-level expression of bovine beta-lactoglobulin gene in transgenic mice JOURNAL OF BIOTECHNOLOGY 61: 191-198. 1998
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Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen S, Pääkkönen M, Marin S, Kosma V-M, Jänne J. 1997. Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. INTERNATIONAL JOURNAL OF CANCER 70: 644-648. 1997