Mikko Hiltunen

de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M]. 2021. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores Nature communications 12 1: 3417. 2021

Natarajan, Pradeep; Pampana, Akhil; Graham, Sarah E; Ruotsalainen, Sanni E; Perry, James A; de Vries, Paul S;. Broome, Jai G; Pirruccello, James P; Honigberg, Michael C; Aragam, Krishna; Wolford, Brooke; Brody, Jennifer A; Antonacci-Fulton, Lucinda; Arden, Moscati; Aslibekyan, Stella; Assimes, Themistocles L; Ballantyne, Christie M; Bielak, Lawrence F; Bis, Joshua C.; Cade, Brian E; et al. [incl. . 2021. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices Nature communications 12 1: 2182. 2021

Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; Miranda-Lourenço, Catarina; Fonseca-Gomes, João; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastião, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luísa V.; de Mendonça, Alexandre; Diógenes, Maria José; Hiltunen, Mikko. 2021. S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5 Neurobiology of disease 2022; 163: 105603. 2021

Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James P.; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven A.; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana et al. [incl. Mannermaa, Arto; Heikkinen, Sami; Kosma, Vel. 2021. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection Nature medicine 27 6: 1012-1024. 2021

Wittrahm, Rebekka; Takalo, Mari; Marttinen, Mikael; Kuulasmaa, Teemu; Mäkinen, Petra; Kemppainen, Susanna; Martiskainen, Henna; Rauramaa, Tuomas; Pike, Ian; Leinonen, Ville; Natunen, Teemu; Haapasalo, Annakaisa; Hiltunen, Mikko. 2021. MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation Cells 10 4: 860. 2021

Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus Journal of clinical medicine 10 5: 1105. 2021

Tienari, Pentti; Tanila, Heikki; Hiltunen, Mikko. 2021. Mikrogliasolut hoidon kohteeksi hermoston rappeumasairauksissa Duodecim 137 18: 1909-1911. 2021

Strausz, Satu; Kiiskinen, Tuomo; Broberg, Martin; Ruotsalainen, Sanni; Koskela, Jukka; Bachour, Adel; FinnGen [incl. Hiltunen, Mikko]; Palotie, Aarno; Palotie, Tuula; Ripatti, Samuli; Ollila, Hanna M.. 2021. Sleep apnoea is a risk factor for severe COVID-19 BMJ open respiratory research 8 1: e000845. 2021

Stenroos, Petteri; Pirttimäki, Tiina; Paasonen, Jaakko; Paasonen, Ekaterina; Salo, Raimo A; Koivisto, Hennariikka; Natunen, Teemu; Mäkinen, Petra; Kuulasmaa, Teemu; Hiltunen, Mikko; Tanila, Heikki; Gröhn, Olli. 2021. Isoflurane affects brain functional connectivity in rats 1 month after exposure Neuroimage 234: 117987. 2021

Ruotsalainen, Sanni E.; Partanen, Juulia J.; Cichonska, Anna; Lin, Jake; Benner, Christian; Surakka, Ida; FinnGen [incl. Hiltunen, Mikko]; Reeve, Mary Pat; Palta, Priit; Salmi, Marko; Jalkanen, Sirpa; Ahola-Olli, Ari; Palotie, Aarno; Salomaa, Veikko; Daly, Mark J; Pirinen, Matti; Ripatti, Samuli; Koskela, Jukka. 2021. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease European journal of human genetics 29 2: 309-324. 2021

Palomäki, Antti; FinnGen Rheumatology Clinical Expert Group; Palotie, Aarno; Koskela, Jukka; Eklund, Kari K; Pirinen, Matti; FinnGen; Ripatti, Samuli; Laitinen, Tarja; Mars, Nina; [incl. collaborators Kosma, Veli-Matti; Mannermaa, Arto; Heikkinen, Sami]. 2021. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers Annals of the rheumatic diseases 80 12: 1530-1536. 2021

Nerg, Ossi; Junkkari, Antti; Hallikainen, Ilona; Rauramaa, Tuomas; Luikku, Antti; Hiltunen, Mikko; Jääskeläinen, Juha E.; Leinonen, Ville; Hänninen, Tuomo; Koivisto, Anne;. 2021. The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease Journal of Alzheimer's disease 81 3: 1117-1130. 2021

Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. 2021. A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population Journal of Alzheimer's disease 83 3: 1325-1332. 2021

Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. 2021. Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut Duodecim 137 13: 1375- 1382. 2021

Kyyriäinen, Jenni; Kajevu, Natallie; Bañuelos, Ivette; Lara, Leonardo; Lipponen, Anssi; Balosso, Silvia; Hämäläinen, Elina; Das Gupta, Shalini; Puhakka, Noora; Natunen, Teemu; Ravizza, Teresa; Vezzani, Annamaria; Hiltunen, Mikko; Pitkänen, Asla. 2021. Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury International journal of molecular sciences 22 19: 10555. 2021

Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L et al. [incl FinGen; Mannermaa, Arto; Heikkinen, Sam. 2021. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries Nature communications 12 1: 1258. 2021

Gudmundsson, Sanna; Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A. et al [incl. Hiltune. 2021. Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans Nature 597 7874: E3-E4. 2021

Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville. 2021. Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 80 4: 1629-1642. 2021

Korpioja, Anita; Krüger, Johanna; Koivuluoma, Susanna; Pylkäs, Katri; Moilanen, Virpi; Helisalmi, Seppo; Hiltunen, Mikko; Remes, Anne M; Zhu, Ling-Qiang. 2021. Novel Rare SORL1 Variants in Early-Onset Dementia Journal of Alzheimer's disease 82 2: 761-770. 2021

Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa. 2021. C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction Neurobiology of disease 2022; 162: 105584. 2021

Leinonen, Ville; Kuulasmaa, Teemu; Hiltunen, Mikko. 2021. iNPH - the mystery resolving Embo molecular medicine 13 3: e13720. 2021

Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. 2021. FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 Molecular neurobiology 58 11: 5438-5458. 2021

Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa. 2021. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells Biochimica et biophysica acta: molecular cell research 1868 7: 119021. 2021

Liuska, PJ; Lemmelä, S; Havulinna, AS; Kaarniranta, K; Uusitalo, H; Laivuori, H; Kiiskinen, T; Daly, MJ; Palotie, A; Turunen, JA. 2021. Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population JAMA ophthalmology 139 7: 762-768. 2021

Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus European journal of neurology 2021; 28 2: 389-400. 2020

Whiffin, Nicola; Karczewski, Konrad J; Zhang, Xiaolei; Chothani, Sonia; Smith, Miriam J; Evans, D Gareth; Roberts, Angharad M; Quaife, Nicholas M; Schafer, Sebastian; Rackham, Owen; Alföldi, Jessica; O'Donnell-Luria, Anne H; Francioli, Laurent C; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals Nature communications 11: 2523. 2020

Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco AS; Merchant, Kalpana M; Genome Aggregation Database Production Team; Genome Aggregation Database Co. 2020. The effect of LRRK2 loss-of-function variants in humans Nature medicine 26: 869-877. 2020

Wang, Qingbo; Pierce-Hoffman, Emma; Cumings, Beryl B; Alföldi, Jessica; Francioli, Laurent C; Gauthier, Laura D; Hill, Andrew J; O'Donnell-Luria, Anne H; Genome Aggregation Database Production Team, Genome Aggregation Database Consortium [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes Nature communications 11: 2539. 2020

Takalo, Mari; Wittrahm, Rebekka; Wefers, Benedikt; Parhizkar, Samira; Jokivarsi, Kimmo; Kuulasmaa, Teemu; Mäkinen, Petra; Martiskainen, Henna; Wurst, Wolfgang; Xiang, Xianyuan; Marttinen, Mikael; Poutiainen, Pekka; Haapasalo, Annakaisa; Hiltunen, Mikko; Haass, Christian. 2020. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions Molecular neurodegeneration 15 1: 52. 2020

Räsänen, Joel; Huovinen, Joel; Korhonen, Ville E; Junkkari, Antti; Kastinen, Sami; Komulainen, Simo; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; Lönnrot, Kimmo; Perola, Markus; Koivisto, Anne M; Remes, Anne M; Soininen, Hilkka; Hiltunen, Mikko; Helisalmi, Seppo; Kurki, Mitja I [et al. incl. Jääskeläinen, Juha E: Leinonen, Ville]. 2020. Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members Fluids and barriers of the cns 17: 57. 2020

Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa. 2020. BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci Frontiers in neurology 11: 550140. 2020

Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodová, Helena; Leppänen, Luukas; Kemiläinen, Benjam; Ryhänen, Simo; Kuulasmaa, Teemu: Rahunen, Eija: Juutinen, Sisko; Mäkinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamäki, Jussi; Haapasalo, Annakaisa; et al [incl. Leinonen, Ville; Tanila, H. 2020. Diabetic phenotype in mouse and humans reduces the number of microglia around ß-amyloid plaques Molecular neurodegeneration 15: 66. 2020

Minikel, Eric Vallabh; Karczewski, Konrad J; Martin, Hilary C; Cummings, Beryl B; Whiffin, Nicola; Rhodes, Daniel; Alföldi, Jessica; Trembath, Richard C; van Heel, David A; Daly, Mark J; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber, Stuart L; MacArthur, Daniel G [Incl. Hiltunen, Mikko; Laakso, Markku; Soininen, Hilkka]. 2020. Evaluating drug targets through human loss-of-function genetic variation Nature 581 7809: 459-464. 2020

Marttinen, Mikael; Ferreira, Catarina B; Paldanius, Kaisa M A; Takalo, Mari; Natunen, Teemu; Mäkinen, Petra; Leppänen, Luukas; Leinonen, Ville; Tanigaki, Kenji; Kang, Gina; Hiroi, Noboru; Soininen, Hilkka; Rilla, Kirsi; Haapasalo, Annakaisa; Hiltunen, Mikko. 2020. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aß Cells 9 11: 2482. 2020

Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. The role of polygenic risk and susceptibility genes in breast cancer over the course of life Nature communications 11 1: 6383. 2020

Luukkainen, L; Huttula, S; Väyrynen, H; Helisalmi, S; Kytövuori, L; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2020. Mutation Analysis of the Genes Associated With Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia Journal of Alzheimer's disease 76 3: 955-965. 2020

Karczewski, Konrad J; Francioli, Laurent C; Tiao, Grace; Cummings, Beryl B; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L; Laricchia, Kristen M; Ganna, Andre; Birnbaum, Daniel P; Gauthier, Laura D; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M; Seaby, Eleanor G; Kosmicki, Jack A; Walters, Raymond K; et al.; Genome Aggregation Dat. 2020. The mutational constraint spectrum quantified from variation in 141,456 humans Nature 581 7809: 434-443. 2020

Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease. Journal of Alzheimer's disease 74 1: 277-286. 2020

Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anais-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Chécler, Frédéric; Farinelli, Mélissa; Delay, Charlotte; et.al.. 2020. Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner Molecular psychiatry 2021; 26 10: 5592-5607. 2020

Cummings, Beryl B; Karczewski, Konrad J; Kosmicki, Jack A; Seaby, Eleanor G; Watts, Nicholas A; Singer-Berk, Moriel; Mudge, Jonathan M; Karjalainen, Juha; Satterstrom, F Kyle; O'Donnell-Luria, Anne H; Poterba, Timothy; Seed, Cotton; Solomonson, Matthew; Alföldi, Jessica; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Daly, Mark J; MacArthur, Daniel G; et al. [. 2020. Transcript expression-aware annotation improves rare variant interpretation Nature 581 7809: 452-458. 2020

Collins, Ryan L; Brand, Harrison; Karczewski, Konrad J; Zhao, Xuefang; Alföldi, Jessica; Francioli, Laurent C; Khera, Armit V; Lowther, Chelsea; Gauthier, Laura D; Wang, Harold; Watts, Nicholas A; Solomonson, Matthew; O'Donnell-Luria, Anne; Baumann, Alexander; Munshi, Ruchi; Walker, Mark; Whelan, Christopher W; Huang, Yongqing; Brookings, Ted; Sharpe, Ted; et al.; Genome Aggregation Database Produ. 2020. A structural variation reference for medical and population genetics Nature 581 7809: 444-451. 2020

Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A. 2019. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned International journal of molecular sciences 20 21: 5395. 2019

Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen,. 2019. Genetic architecture of human plasma lipidome and its link to cardiovascular disease Nature communications 10: 4329. 2019

Sartori, M; Mendes, T; Desai, S; Lasorsa, A; Herledan, A; Malmanche, N; Mäkinen, P; Marttinen, M; Malki, I; Chapuis, J; Flaig, A; Vreulx, AC; Ciancia, M; Amouyel, P; Leroux, F; Déprez, B; Cantrelle, FX; Maréchal, D; Pradier, L; Hiltunen, M; et al.. 2019. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation Acta neuropathologica 138 4: 631-652. 2019

Rostalski, Hannah; Leskelä, Stina; Huber, Nadine; Katisko, Kasper; Cajanus, Antti; Solje, Eino; Marttinen, Mikael; Natunen, Teemu; Remes, Anne M; Hiltunen, Mikko; Haapasalo, Annakaisa. 2019. Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS Frontiers in neuroscience 13: 486. 2019

Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. [11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus Journal of Alzheimer's disease 67 4: 1343-1351. 2019

Moradi, E; Marttinen, M; Häkkinen, T; Hiltunen, M; Nykter, M. 2019. Supervised pathway analysis of blood gene expression profiles in Alzheimer's disease Neurobiology of aging 84: 98-108. 2019

Luukkainen, L; Helisalmi, S; Kytövuori, L; Ahmasalo, R; Solje, E; Haapasalo, A; Hiltunen, M; Remes, AM; Krüger, J. 2019. Mutation Analysis of the Genes Linked to Early Onset Alzheimer's Disease and Frontotemporal Lobar Degeneration Journal of Alzheimer's disease 69 3: 775-782. 2019

Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 71 4: 1233-1243. 2019

Kunkle, BW; Grenier-Boley, B; Sims, R; Bis, JC; Damotte, V; Naj, AC; Boland, A; Vronskaya, M; van der Lee, S; Amlie-Wolf, A; Bellenguez, C; Frizatti, A; Chouraki, V; Martin, ER; Sleegers, K; Badarinarayan, N; Jakobsdottir, J; Hamilton-Nelson, KL; Moreno-Grau, S; Olaso R; et al. (Incl. Hiltunen, Mikko; Haapasalo; Annakaisa; Helisalmi, Seppo; Koivisto, Anne; Soininen, Hilkka). 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nature genetics 51 3: 414-430. 2019

Leskelä, S; Huber, N; Rostalski, H; Natunen, T; Remes, AM; Takalo, M; Hiltunen, M; Haapasalo, A. 2019. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner Cells 8 10: 1233. 2019

Leinonen, Ville; Junkkari, Antti; Rauramaa, Tuomas; Jääskeläinen, Juha E; Vanninen, Ritva; Savolainen, Sakari; Hiltunen, Mikko; Remes, Anne M; Koivisto, Anne M. 2019. Normaalipaineisen hydrokefaluksen kliininen kuva, diagnostiset tutkimukset ja hoito Duodecim 135 3: 265-273. 2019

Korhonen, VE; Remes, AM; Helisalmi, S; Rauramaa, T; Sutela, A; Vanninen, R; Suhonen, NM; Haapasalo, A; Hiltunen, M; Jääskeläinen, JE; Soininen, H; Koivisto, AM; Leinonen, V. 2019. Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus Dementia and geriatric cognitive disorders 47 1-2: 91-103. 2019

Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients Journal of Alzheimer's disease 72 1: 127-137. 2019

Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019

Gabbouj, Sami; Ryhanen, Simo; Marttinen, Mikael; Wittrahm, Rebekka; Takalo, Mari; Kemppainen, Susanna; Martiskainen, Henna; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko; Natunen, Teemu. 2019. Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway Frontiers in neuroscience 13: 629. 2019

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Haapala, Eero A; Paananen, Jussi; Hiltunen, Mikko; Lakka, Timo A. 2018. Associations of Genetic Susceptibility to Alzheimer's Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study Journal of Alzheimer's Disease 64 2: 587-595. 2018

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Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. 2017. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9 6: 1885-1897. 2017

Ylönen Susanna, Siitonen Ari, Nalls Michael A, Ylikotila Pauli, Autere Jaana, Eerola-Rautio Johanna, Gibbs Raphael, Hiltunen Mikko, Tienari Pentti J, Soininen Hilkka, Singleton Andrew B, Majamaa Kari. 2017. Genetic risk factors in Finnish patients with Parkinson's disease. PARKINSONISM & RELATED DISORDERS 45: 39-43. 2017

Takalo Mari, Natunen Teemu, Leskelä Stina, Paldanius Kaisa MA, Soininen Hilkka, Hiltunen MIkko, Haapasalo Annakaisa. 2017. New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1 Journal of Alzheimer's disease & Parkinsonism 7 5: 365. 2017

Suhonen N-M, Haanpää RM, Korhonen V, Jokelainen J, Pitkäniemi A, Heikkinen A-L, Krüger J, Hartikainen P, Helisalmi S, Hiltunen M, Hänninen T, Remes AM. 2017. Neuropsychological Profile in the C9ORF72 Associated Behavioral Variant Frontotemporal Dementia. Journal of Alzheimer's Disease 58 2: 479-489. 2017

Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD et al.. 2017. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. PLOS ONE 12 10: e0185777. 2017

Sims Rebecca, van der Lee Sven J, Naj Adam C, Bellenguez Celine, Badarinarayan Nandini, Jakobsdottir Johanna, Kunkle Brian W, Boland Anne, Raybould Rachel, Bis Joshua C, Martin Eden R, Grenier-Boley Benjamin, Heilmann-Heimbach Stefanie, Chouraki Vincent, Kuzma Amanda B, Sleegers Kristel, Vronskaya Maria, Ruiz Agustin, Graham Robert R, Olaso Robert et al., ARUKConsortium, GERAD PERADES, CHARGE, ADG. 2017. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. NATURE GENETICS 49 9: 1373-1384. 2017

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A. 2017. Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy. EPILEPSY RESEARCH 136: 18-34. 2017

Marttila Maria, Kytövuori Laura, Helisalmi Seppo, Kallio Mika, Laitinen Marjo, Hiltunen Mikko, Kärppä Mikko, Majamaa Kari. 2017. Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study. NEUROEPIDEMIOLOGY 49 1-2: 34-39. 2017

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. 2017. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. JOURNAL OF NEUROINFLAMMATION [HTTP://WWW.JNEUROINFLAMMATION.COM/] 14: 215. 2017

Adam A, Robison J, Lu J, Jose R, Hiltunen M, Huovinen J, Helisalmi S, Paananen J, Koivisto AM, Remes AM, Soininen H, Kurki M, Jääskeläinen JE, Leinonen V et al. 2017. Abstracts from Hydrocephalus 2016. Fluids and barriers of the CNS 14: 15. 2017

Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers. ANNALS OF NEUROLOGY 82 1: 128-132. 2017

Kumari K, Koivisto H, Viluksela M, Paldanius KMA, Marttinen M, Hiltunen M, Naarala J, Tanila H, Juutilainen J. 2017. Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment PLOS ONE 12 12: e0188880. 2017

Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. 2017. Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Journal of Alzheimer's disease 60 3: 1077-1085. 2017

Yan Xu, Nykänen Niko-Petteri, Brunello Cecilia A, Haapasalo Annakaisa, Hiltunen Mikko, Uronen Riikka-Liisa, Huttunen Henri J. 2016. FRMD4A-cytohesin signaling modulates the cellular release of tau. JOURNAL OF CELL SCIENCE 129 10: 2003-2015. 2016

Solje Eino, Riipinen Pirkko, Helisalmi Seppo, Särkioja Terttu, Laitinen Marjo, Hiltunen Mikko, Hakko Helinä, Remes Anne M. 2016. The role of the FTD-ALS associated C9orf72 expansion in suicide victims Amyotrophic lateral sclerosis & frontotemporal degeneration 17 7-8: 589-592. 2016

Solje Eino, Miettunen Jouko, Marttila Riikka, Helisalmi Seppo, Laitinen Marjo, Koivumaa-Honkanen Heli, Isohanni Matti, Hiltunen Mikko, Jääskeläinen Erika, Remes Anne M. 2016. The C9ORF72 expansion sizes in patients with psychosis: a population-based study on the Northern Finland Birth Cohort 1966 Psychiatric genetics 26 2: 92-94. 2016

Russell Claire L, Mitra Vikram, Hansson Karl, Blennow Kaj, Gobom Johan, Zetterberg Henrik, Hiltunen Mikko, Ward Malcolm, Pike Ian. 2016. Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates. Journal of Alzheimer's Disease 2017; 55 1: 303-313. 2016

Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus Acta neurochirurgica 158 12: 2311-2319. 2016

Rilla Kirsi, Hiltunen Mikko. 2016. Ekstrasellulaarivesikkelit tulevaisuuden biomarkkereina. BestPractice Psykiatria/neurologia: lääketieteen asiantuntijoiden ammattilehti 4 16 (Lokakuu 2016): 11-13. 2016

Laiterä Tiina, Paananen Jussi, Helisalmi Seppo, Sarajärvi Timo, Huovinen Joel, Laitinen Marjo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Leinonen Ville, Hiltunen Mikko. 2016. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-ß Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's Disease 2017; 55 3: 995-1003. 2016

Kurkinen Kaisa MA, Marttinen Mikael, Turner Laura, Natunen Teemu, Mäkinen Petra, Haapalinna Fanni, Sarajärvi Timo, Gabbouj Sami, Kurki Mitja, Paananen Jussi, Koivisto Anne M, Rauramaa Tuomas, Leinonen Ville, Tanila Hanila, Soininen Hilkka, Lucas Fiona R, Haapasalo Annakaisa, Hiltunen Mikko. 2016. SEPT8 modulates ß-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. JOURNAL OF CELL SCIENCE 129: 2224-2238. 2016

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. 2016. Familial idiopathic normal pressure hydrocephalus. JOURNAL OF THE NEUROLOGICAL SCIENCES 368: 11-18. 2016

Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. 2016. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. MOLECULAR PSYCHIATRY [Epub ahead of print]: 1-10. 2016

Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko. 2015. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. PROGRESS IN NEUROBIOLOGY epub ahead of print 19 May 2015. 2015

Ziyatdinova Sofya, Viswanathan Jayashree, Hiltunen Mikko, Tanila Heikki, Pitkänen Asla. 2015. Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. EPILEPSY RESEARCH 112: 43-55. 2015

Steinberg Stacy, Stefansson Hreinn, Jonsson Thorlakur, Johannsdottir Hrefna, Ingason Andres, Helgason Hannes, Sulem Patrick, Magnusson Olafur Th, Gudjonsson Sigurjon A, Unnsteinsdottir Unnur, Kong Augustine, Helisalmi Seppo, Soininen Hilkka, Lah James J, DemGene, Aarsland Dag, Fladby Tormod, Ulstein Ingun D, Djurovic Srdjan, Sando Sigrid B (incl. Hiltunen Mikko). 2015. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. NATURE GENETICS 47 5: 445-447. 2015

Sarajärvi Timo, Marttinen Mikael, Natunen Teemu, Kauppinen Tarja, Mäkinen Petra, Helisalmi Seppo, Laitinen Marjo, Rauramaa Tuomas, Leinonen Ville, Petäjä-Repo Ulla, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Genetic Variation in delta-Opioid Receptor Associates with Increased ß- and gamma-Secretase Activity in the Late Stages of Alzheimer's Disease. Journal of Alzheimer's Disease 48 2: 507-516. 2015

Salminen Antero, Jouhten Paula, Sarajärvi Timo, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease. NEUROCHEMISTRY INTERNATIONAL 92 January 2016: 13-24. 2015

Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. Journal of Alzheimer's Disease 46 1: 261-269. 2015

Remes Anne, Hiltunen Mikko, Castrén Maija, Pöyhönen Minna. 2015. Muistisairauksien genetiikka ja perinnölliset muistisairaudet. Teoksessa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen (toim.) Muistisairaudet. KUSTANNUS OY DUODECIM. s. 194-. 2015

Natunen Teemu, Takalo Mari, Kemppainen Ssusanna, Leskelä Stina, Marttinen Mikael, Kurkinen Kaisa MA, Pursiheimo Juha-Pekka, Sarajärvi Timo, Viswanathan Jayashree, Gabbouj Sami, Solje Eino, Tahvanainen Eveliina, Pirttimäki Tiina, Kurki Mitja, Paananen Jussi, Rauramaa Tuomas, Miettinen Pasi, Mäkinen Petra, Leinonen Ville, Soininen Hilkka et al. 2015. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models Neurobiology of disease 2016; 85: 187-205. 2015

Marttinen Mikael, Kurkinen Kaisa MA, Soininen Hilkka, Haapasalo Annakaisa, Hiltunen Mikko. 2015. Synaptic dysfunction and septin protein family members in neurodegenerative diseases. MOLECULAR NEURODEGENERATION 10 16: 12 p. 2015

Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach. Journal of Alzheimer's Disease 43 2: 565-573. 2015

Laiterä Tiina, Kurki Mitja I, Pursiheimo Juha-Pekka, Zetterberg Henrik, Helisalmi Seppo, Rauramaa Tuomas, Alafuzoff Irina, Remes Anne M, Soininen Hilkka, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville. 2015. The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's Disease 48 4: 959-968. 2015

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA et al (incl. Hilkka Soininen and Mikko Hiltunen). 2015. A novel Alzheimer disease locus located near the gene encoding tau protein. MOLECULAR PSYCHIATRY 2016; 21 1: 108-117. 2015

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M. 2014. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25 6: 634-641. 2014

Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai. 2014. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. AGEING RESEARCH REVIEWS 16: 45-65. 2014

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. CELLULAR SIGNALLING 26: 1598-1603. 2014

Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu. 2014. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. JOURNAL OF MOLECULAR MEDICINE -: -. 2014

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus. PLOS ONE [ONLINE] 9 3; e91974: 1-10. 2014

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2014. Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences. Sleep and Breathing 18 3: 641-647. 2014

Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. 2014. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models. NEUROBIOLOGY OF AGING 36 2: 1221.e15-1221.e28. 2014

Lipsanen Anu, Parkkinen Saara, Khabbal Joonas, Mäkinen Petra, Peräniemi Sirpa, Hiltunen Mikko, Jolkkonen Jukka. 2014. KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. NEUROSCIENCE LETTERS 580: 173-177. 2014

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. 2014. Increased y-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with b-Amyloid Pathology. PLOS ONE [ONLINE] 3 9: e93717: 1-8. 2014

Kurki MI, Gaál EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, van 't Hof FN, von Und Zu Fraunberg M, Helisalmi S, Hiltunen M, Lehto H2, Laakso A, Kivisaari R, Koivisto T, Ronkainen A, Rinne J, Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, Aromaa A, Perola M, Lehtimäki T, Raitakari OT, Salomaa V, Gunel M, Dermitzakis ET, Ruigrok YM, Rinkel GJ, Niemelä M, Hernesniemi J, Ripatti S, de B. 2014. High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLOS GENETICS [ONLINE) 10 1: e1004134. 2014

Jones L, Lambert J, Wang L, Choi S, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards A, Bellenguez C, Ibrahim-Verbaas CA, Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, ..., Soininen H, et al., (International Genomics of Alzheimer's Disease Consortium (IGAP); International Genomics of Alzheimer's Disease Consortium IGAP). 2014. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia 2014 Available online 2014 Dec 20: 1-14. 2014

Helisalmi Seppo, Immonen Ilkka, Losonczy Gergely, Resch Miklos D, Benedek Szabolcs, Balogh Istvan, Papp Andras, Berta Andras, Uusitupa Matti, Hiltunen Mikko, Kaarniranta Kai. 2014. ADAMTS9 locus associates with increased risk of wet AMD. ACTA OPHTHALMOLOGICA 2014: 1. 2014

Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients. NEURODEGENERATIVE DISEASES 14 4 (Online First Articles): 204-208. 2014

Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert J-C, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA et.al.. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLOS ONE [ONLINE] 9 6: e94661. 2014

Viswanathan J, Haapasalo A, Kurkinen KMA, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells. BIOCHEMISTRY 52: 3899-3912. 2013

Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. 2013. Protein aggregation and degradation mechanisms in neurodegenerative diseases. American Journal of Neurodegenerative Disease 2 1: 1-14. 2013

Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KMA, Tanzi RE, Soininen H, Hiltunen M. 2013. Targeting ubiquilin-1 in Alzheimer's disease. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 795-810. 2013

Natunen Teemu, Martiskainen Henna, Sarajärvi Timo, Helisalmi Seppo, Pursiheimo Juha-Pekka, Viswanathan Jayashree, Laitinen Marjo, Kauppinen Tarja, Rauramaa Tuomas, Leinonen Ville, Alafuzoff Irina, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2013. Effects of NR1H3 genetic variation on the expression of liver X receptor alfa and the progression of Alzheimer's Disease. PLOS ONE [ONLINE] 8 11: e80700. 2013

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. 2013. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. PROGRESS IN NEUROBIOLOGY 106-107: 33-54. 2013

Rubio-Moscardo Fanny, Seto-Salvia Nuria, Pera Marta, Bosch-Morato Monica, Plata Christina, Belbin Olivia, Gene Gemma, Dols-Icardo Oriol, Ingelsson Martin, Helisalmi Seppo, Soininen Hilkka, Hiltunen Mikko, Giedraitis Vilmantas, Lannfelt Lars, Frank Ana, Bullido Ma Jesus, Combarros Onofre, Sanchez-Juan Pascual et.al.. 2013. Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's Disease patients alter calcium homeostasis. PLOS ONE [ONLINE] 8 9: e74203. 2013

Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. 2013. γ-Secretase Components as Predictors of Breast Cancer Outcome. PLOS ONE [ONLINE] 8 11: e79249, 1-13. 2013

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. 2013. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS -: -. 2013

Natunen T, Parrado AR, Helisalmi S, Pursiheimo J-P, Sarajärvi T, Mäkinen P, Kurkinen KMA, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. 2013. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's Disease. Journal of Alzheimer's Disease 37: 217-232. 2013

Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. 2013. Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. EXPERT OPINION ON THERAPEUTIC TARGETS 17 7: 781-794. 2013

Lipsanen A, Kalesnykas G, Pro-Sistiaga P, Hiltunen M, Vanninen R, Bernaudin M, Touzani O, Jolkkonen J. 2013. Lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates. EXPERIMENTAL NEUROLOGY 248: 224-227. 2013

Lipsanen A, Flunkert S, Kuptsova K, Hiltunen M, Windisch M, Hutter-Paier B, Jolkkonen J. 2013. Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. PLOS ONE [ONLINE] 8 3: e60235. 2013

Lambert JC,Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, ... Soininen H, ... Hiltunen M et al.. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. NATURE GENETICS Dec; 45 (12): 1452-8. 2013

Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients. Journal of Alzheimer's Disease 33: 23-27. 2013

Hiltunen M, Haapasalo A, Soininen H. 2013. Alzheimern taudin uudet riskigeenit - tautia ennakoivat biomarkkerit?. DUODECIM 129: 583-588. 2013

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLOS ONE [ONLINE] 8 4: e59676. 2013

Muraja-Murro A, Kulkas A, Hiltunen M, Kupari S, Hukkanen T, Tiihonen P, Mervaala E, Töyräs J. 2013. The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea. Journal of Sleep Research 22 6: 663-669. 2013

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. 2012. APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 83 11: 1119-1124. 2012

Viswanathan J, Soininen H, Hiltunen M. 2012. Genetics of Alzheimer's disease. Teoksessa: Gauthier S, Rosa-Neto P (toim.), Advances in Alzheimer's Disease Management. ss. 2-9. 2012

Vepsäläinen Saila, Koivisto Henna, Pekkarinen Elina, Mäkinen Petra, Dobson Gary, McDougall Gordon J, Stewart Derek, Haapasalo Annakaisa, Karjalainen Reijo O, Tanila Heikki, Hiltunen Mikko. 2012. Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 24: 360-370. 2012

Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings NEUROLOGY 78: 1568-1575. 2012

Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16 11: 2754-2767. 2012

Salminen, A; Kaarniranta, K; Haapasalo, A; Hiltunen, M; Soininen, H; Alafuzoff, I. 2012. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 96: 87-95. 2012

Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C et al.. 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. MOLECULAR PSYCHIATRY -: -. 2012

Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease Journal of Alzheimer's Disease 28: 553-559. 2012

Huumonen Katriina, Immonen Hanna-Kaisa, Baverstock Keith, Hiltunen Mikko, Korkalainen Merja, Lahtinen Tapani, Parviainen Juha, Viluksela Matti, Wong Garry, Naarala Jonne, Juutilainen Jukka. 2012. Radiation-induced genomic instability in Caenorhabditis elegans. MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 748 748: 36-41. 2012

Hiltunen Mikko, Jolkkonen Jukka. 2012. Letter by Hiltunen and Jolkkonen Regarding Article, "Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?". STROKE 43: e97. 2012

Hiltunen Mikko, Hallikainen Merja, Haapasalo Annakaisa, Soininen Hilkka. 2012. Alzheimerin taudin perustutkimuksesta uusiin lääkehoitoihin [with English Summary: From basic research towards novel therapies in Alzheimer's disease] DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 28 1: 25-31. 2012

Hiltunen M, Khandelwal VKM, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, Krzisch M, Vepsäläinen S, Mäkinen P, Kemppainen S, Miettinen P, Haapasalo A, Soininen H, Laakso M, Tanila H. 2012. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16: 1206-1222. 2012

Hiltunen M, Jolkkonen J. 2012. Secondary neurodegeneration in remote regions after focal cerebral infarction: A new target for Stroke Management STROKE 43: e96. 2012

Lipsanen Anu, Hiltunen Mikko, Jolkkonen Jukka. 2011. Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 99: 468-474. 2011

Viswanathan Jayashree, Haapasalo Annakaisa, Böttcher Claudia, Miettinen Riitta, Kurkinen Kaisa MA, Lu Alice, Thomas Anne, Maynard Christa J, Romano Donna, Hyman Bradley T, Berezovska Oksana, Bertram Lars, Soininen Hilkka, Dantuma Nico P, Tanzi RE, Hiltunen Mikko. 2011. Alzheimer's disese-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12: 330-348. 2011

Turunen Mari, Vepsäläinen Saila, Mäkinen Petra, Helisalmi Seppo, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2011. No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease. NEUROBIOLOGY OF AGING 32: 547.e7-547.e9. 2011

Tolppanen AM, Helisalmi S, Hiltunen M, Kolehmainen M, Schwab U, Pirttilä T, Pulkkinen L, Uusitupa M & Soininen H.. 2011. Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. Negative results. NEUROBIOLOGY OF AGING 32: 546.e7-546.e9. 2011

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. 2011. Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 34: 3-11. 2011

Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. 2011. AMP-activated protein kinase: a potential player in Alzheimer's disease JOURNAL OF NEUROCHEMISTRY 118: 460-474. 2011

Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. 2011. Emerging role of p62/sequestosome-1 in th pathogenesis of Alzheimer's disease PROGRESS IN NEUROBIOLOGY 96: 87-95. 2011

Sarajärvi Timo, Tuusa Jussi T, Haapasalo Annakaisa, Lackman Jarkko T, Sormunen Raija, Helisalmi Seppo, Roehr Johannes T, Parrado Antonio R, Mäkinen Petra, Bertram Lars, Soininen Hilkka, Tanzi Rudolph E, Petäjä-Repo Ulla E, Hiltunen Mikko. 2011. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. MOLECULAR AND CELLULAR BIOLOGY 31 11: 2326-2340. 2011

Lambert J, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, Tognoni G, Fievet N, Boland A, Arosio B, Coto E, Del Zompo M, Mateo I, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri F, Delepine M et al.. 2011. Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations NEUROBIOLOGY OF AGING 32: 756.e11-756.e15. 2011

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J et al.. 2011. Common variants at ABCA7,MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease NATURE GENETICS 43 5: 429-435. 2011

Hiltunen M, Jolkkonen J. 2011. Complex pathology in the thalamus following cerebral ischemia: Song JL, Thalamus: Anatomy, Functions and Disorders. 83-98. 2011

Hiltunen M, Bertram L, Saunders AJ. 2011. Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease International Journal of Alzheimer's Disease ID 925362: 1-2. 2011

Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 31: 1119-1132. 2011

Haapasalo A, Viswanathan J, Kurkinen KMA, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. 2011. Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Communicative & Integrative Biology 4 4: 428-432. 2011

Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fievet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S et al.. 2011. APOE and Alzheimer disease: a major gene with semi-dominant inheritance MOLECULAR PSYCHIATRY 16: 903-907. 2011

Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. 2011. Age-related macular degeneration (AMD): Alzheimer's Disease in the eye Journal of Alzheimer's Disease 24: 615-631. 2011

Pelkonen A, Hiltunen M, Kiianmaa K & Yavich L. 2010. Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference. JOURNAL OF NEUROCHEMISTRY 114 4: 1168-1176. 2010

Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK, Haapasalo A, Soininen H, Hiltunen M. 2010. An association study of 21 potential Alzheimer's disease risk genes in a Finnish population. Journal of Alzheimer's Disease 21 3: 763-767. 2010

Salminen A, Ojala J, Kaarniranta K, Hiltunen M & Soininen H. 2010. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. PROGRESS IN NEUROBIOLOGY 93: 99-110. 2010

Giedraitis V, Glaser A, Sarajärvi T, Brundin RM, Degerman Gunnarsson M, Schjeide BM, Tanzi RE, Helisalmi S et al. 2010. CALHM1 P86L polymorphism does not alter amyloid-beeta or tau in cerebrospinal fluid. NEUROSCIENCE LETTERS 469: 265-267. 2010

Martikainen P, Pikkarainen M, Pöntynen K, Hiltunen M, Lehtovirta M, Tuisku S, Soininen H & Alafuzoff I. 2010. Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 36: 41-54. 2010

Lambert JC, Sleegers K, Gonzalez-Perez A, Ingelsson M, Beecham GW, Hiltunen M et al. 2010. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's Disease 22 1: 247-255. 2010

Karjalainen Reijo, Hiltunen Mikko, Vepsäläinen Saila, Törrönen Riitta, Saviranta Niina, Hilz Hauke, Bildstein Marie, McDougall Gordon, Stewart Derek, Mattila Pirjo, Tanila Heikki. 2010. Blackcurrant (Ribes nigrum L.) neuroprotective potential: New results from the "BrainHealthFood" project, XXV International conference on polyphenols: Polyphenols communications 2010 volume 1. 26-27. 2010

Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I. 2010. Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain. Journal of Alzheimer's Disease 20: 1015-1028. 2010

Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M, Soininen H, Hiltunen M, Helisalmi S. 2009. An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. AMERICAN JOURNAL OF MEDICAL GENETICS. PART B. NEUROPSYCHIATRIC GENETICS 150B 5: 747-750. 2009

Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Combined risk effects of IDE and NEP gene variants on Alzheimer disease. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 80: 1268-1270. 2009

Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M, Soininen H, Hiltunen M. 2009. Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 284 49: 34433-34443. 2009

Lambert JC, Heath S, Even G..., Hiltunen M, Combarros O..., Helisalmi S, Porcellini E..., Licastro F, Soininen H, Ritchie K..., Amouyel P, Hiltunen M, Helisalmi S, Soininen H. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. NATURE GENETICS 41 10: 1047-1048. 2009

Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE, Hiltunen M, Soininen H. 2009. Effects of ubiquillin 1 on the unfolded protein response. JOURNAL OF MOLECULAR NEUROSCIENCE 38: 19-30. 2009

Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 35: 103-113. 2009

Helisalmi S, Väkevä A, Hiltunen M, Soininen H, Soininen H, Helisalmi S. 2009. Flanking markers of cyntation C (CST3) gene do not show association with Alzheimer's disease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 27: 318-321. 2009

Hiltunen M, van Groen T, Jolkkonen J. 2009. Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: Evidence from experimental studies. Journal of Alzheimer's Disease 18: 401-412. 2009

Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Genetic study evaluating LDLR polymorphisms and Alzheimer's disease NEUROBIOLOGY OF AGING 29: 848-855. 2008

Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2008. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology. NEUROSCIENCE LETTERS 438: 216-220. 2008

Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28: 263-268. 2008

Helisalmi S, Vepsäläinen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, Soininen H, Soininen H. 2008. Genetic study between SIRT1, PPARD, PGC-1alfa genes and Alzheimer's disease. JOURNAL OF NEUROLOGY 255: 668-673. 2008

Helisalmi S, Tarvainen T, Vepsäläinen S, Koivisto AM, Hiltunen M, Soininen H, Helisalmi S, Hiltunen M, Soininen H. 2008. Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease. NEUROSCIENCE LETTERS 441 2: 233-236. 2008

Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M, Helisalmi S, Soininen H, Hiltunen M. 2008. Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease. EUROPEAN JOURNAL OF HUMAN GENETICS 16: 171-175. 2008

Bertram L, Schjeide BMM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE, Hiltunen M, Soininen H. 2008. No association between CALHM1 and Alzheimers's disease risk. CELL 135: 993-994. 2008

Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 26: 1845-1852. 2007

Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 24: 146-150. 2007

Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. The association study between DHCR24 polymorphisms and Alzheimer's disease. AMERICAN JOURNAL OF MEDICAL GENETICS. PART B. NEUROPSYCHIATRIC GENETICS 144B: 906-910. 2007

Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang S-H, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. 2007. Depletion of GGA3 stabilizes bace and enhances [beta]-secretase activity. NEURON 54 5: 721-737. 2007

Vepsäläinen S, Helisalmi S, Koivisto AM, Tapaninen T, Hiltunen M, Soininen H, Vepsäläinen S, Helisalmi S, Hiltunen M, Soininen H. 2007. Somatostatin genetic variants modify the risk for Alzheimer¿s disease among finnish patients. JOURNAL OF NEUROLOGY 254: 1504-1508. 2007

Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population JOURNAL OF MEDICAL GENETICS 44: 606-608. 2007

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 128: 175-179. 2006

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Plasma cell membrane glycoprotein-1 K121Qmpolymorphism in preeclampsia. GYNECOLOGIC AND OBSTETRIC INVESTIGATION 61: 124-127. 2006

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M, Laakso M, Hiltunen M, Helisalmi S. 2006. Adiponectin gene haplotype is associated with preeclampsia. GENETIC TESTING 10 1: 35-39. 2006

Koivisto AM, Helisalmi S, Pihlajamäki J, Hiltunen M, Koivisto K, Moilanen L, Kuusisto J, Helkala E-L, Hänninen T, Kervinen K, Kesäniemi YA, Laakso M, Soininen H, Koivisto AM, Helisalmi S, Hiltunen M, Soininen H, Laakso M. 2006. Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzhimer¿s disease in the Finnish population. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 22: 449-453. 2006

Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 77: 421-422. 2006

Iivonen S, Heikkinen T, Puoliväli J, Helisalmi S, Hiltunen M, Soininen H, Tanila H, Iivonen S, Helisalmi S, Hiltunen M, Soininen H. 2006. Effects of estradiol on spatial learning, hippocampal cytochrome P450 19, and estrogen alpha and beta mRNA levels in ovariectomized female mice NEUROSCIENCE 137: 1143-1152. 2006

Hiltunen M, Iivonen S, Soininen H, Hiltunen M, Soininen H. 2006. Aromatase enzyme and Alzheimer¿s disease. MINERVA ENDOCRINOLOGICA 31 1: 61-73. 2006

Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. 2005. Family-based association between Alzheimer¿s disease and variants in UBQLN1. NEW ENGLAND JOURNAL OF MEDICINE 352 9: 884-894. 2005

Chaudhuri JD, Hiltunen M, Nykänen M, Ylä-Herttuala S, Soininen H, Miettinen R, Hiltunen M, Soininen H. 2005. Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods. NEUROSCIENCE 131: 557-566. 2005

Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women EUROPEAN JOURNAL OF HUMAN GENETICS 13: 1000-1006. 2005

Puhakka HL, Turunen P, Rutanen J, Hiltunen MO, Turunen MP, Ylä-Herttuala S. 2005. Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model. JOURNAL OF VASCULAR RESEARCH 42 5: 361-367. 2005

Rutanen J, Turunen A-M, Teittinen M, Rissanen TT, Heikura T, Koponen JK, Gruchala M, Inkala M, Jauhiainen S, Hiltunen MO, Turunen MP, Stacker SA, Achen MG, Ylä-Herttuala S. 2005. Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism. GENE THERAPY 12: 980-987. 2005

Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. 2005. APP substitutions V715F and L720P alter PS1 conformation and dirrerentially affect Abeta and AICD generation. JOURNAL OF NEUROCHEMISTRY 95: 446-456. 2005

Turunen P, Puhakka H, Rutanen J, Hiltunen MO, Heikura T, Gruchala M, Ylä-Herttuala S. 2005. Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta ATHEROSCLEROSIS 179 1: 27-33. 2005

Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease. JOURNAL OF NEUROLOGY 252: 423-428. 2005

Yavich L, Oksman M, Tanila H, Kerokoski P, Hiltunen M, van Groen T, Puoliväli J, Männistö PT, García-Horsman A, MacDonald E, Beyreuther K, Hartmann T, Jäkälä P. 2005. Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated alpha-synuclein. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 303-313. 2005

Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. 2005. Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. MOLECULAR HUMAN REPRODUCTION 11 6: 437-440. 2005

Iivonen S, Corder E, Lehtovirta M, Helisalmi S, Mannermaa A, Vepsäläinen S, Hänninen T, Soininen H, Hiltunen M, Iivonen S, Hiltunen M, Soininen H, Helisalmi S, Vepsäläinen S. 2004. Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease. NEUROLOGY 62: 1170-1176. 2004

Toivonen S, Romppanen E-L, Hiltunen M, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S, Helisalmi S. 2004. Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 11: 540-544. 2004

Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin C-H, Östman A, Ylä-Herttuala S. 2004. Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits. CIRCULATION 109: 1140-1146. 2004

Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppänen P, Turunen A-M, Ylä-Herttuala S. 2004. Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vasvular smooth muscle cells. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36 3: 333-341. 2004

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto AM, Alafuzoff I, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Koivisto AM, Soininen H, Iivonen S. 2004. Polymorphisms in neprilysin gene affect the risk of Alzheimer¿s disease in Finnish patients. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY 75: 1746-1748. 2004

Hiltunen M, Helisalmi S, Kivipelto M, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2004. Alzheimerin taudin genetiikka. DUODECIM 120: 2425-2431. 2004

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Corder EH, Lehtovirta M, Mannermaa A, Koivisto AM, Soininen H, Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Koivisto AM, Soininen H. 2004. Genetic variation in apolipoprotein D and Alzheimer¿s disease. JOURNAL OF NEUROLOGY 251: 951-957. 2004

Helisalmi S, Dermaut B, Hiltunen M, Mannermaa A, Van den Broeck M, Lehtovirta M, Koivisto AM, Iivonen S, Cruts M, Soininen H, Van Broeckhoven C, Soininen H. 2004. Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population. NEUROLOGY 63: 173-175. 2004

Faisel F, Romppanen E-L, Hiltunen M, Helisalmi S, Laasanen J, Punnonen K, Salonen JT, Heinonen S, Hiltunen M, Helisalmi S. 2004. Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. EUROPEAN JOURNAL OF HUMAN GENETICS 12: 187-191. 2004

Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, Rutanen J, Kosma V-M, Mahonen A, Kröger H, Ylä-Herttuala S. 2003. Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB JOURNAL 17: 1147-1149. 2003

Hiltunen MO, Ylä-Herttuala S. 2003. DNA methylation, smooth muscle cells. and atherogenesis. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 23: 1750-1753. 2003

Iivonen S, Helisalmi S, Mannermaa A, Alafuzoff I, Lehtovirta M, Soininen H, Hiltunen M. 2003. Heparan sulfate proteoglycan 2 polymorphism in Alzheimer¿s disease and correlation with neuropathology. NEUROSCIENCE LETTERS 352: 146-150. 2003

Mattila KM, Hiltunen M, Rinne JO, Mannermaa A, Röyttä M, Alafuzoff I, Laippala P, Soininen H, Lehtimäki T. 2003. Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer¿s disease in Finnish patients NEUROSCIENCE LETTERS 337: 61-63. 2003

Rutanen J, Leppänen P, Tuomisto TT, Rissanen TT, Hiltunen MO, Vajanto I, Niemi M, Häkkinen T, Karkola K, Stacker SA, Achen MG, Alitalo K, Ylä-Herttuala S. 2003. Vascular endothelial growth factor-D expression in human atherosclerotic lesions. CARDIOVASCULAR RESEARCH 59: 971-979. 2003

Turunen MP, Hiltunen MO, Ylä-Herttuala S. 2003. Cardiovascular gene therapy. Teoksessa: Rolland A, Sullivan SM (toim.) Pharmaceutical Gene Delivery Systems. Ei jufo-kustantaja/not jufo publisher. s. 345-362. 2003

Vajanto I, Rissanen TT, Rutanen J, Hiltunen MO, Tuomisto TT, Arve K, Närvänen O, Manninen H, Räsänen H, Hippeläinen M, Alhava E, Ylä-Herttuala S. 2002. Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ. JOURNAL OF GENE MEDICINE 4: 371-380. 2002

Turunen MP, Puhakka HL, Koponen JK, Hiltunen MO, Rutanen J, Leppänen O, Turunen A-M, Närvänen A, Newby AC, Baker AH, Ylä-Herttuala S. 2002. Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. MOLECULAR THERAPY 6: 306-312. 2002

Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M, Leppänen P, Turunen MP, Markkanen JE, Arve K, Alhava E, Kauppinen RA, Ylä-Herttuala S. 2002. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. AMERICAN JOURNAL OF PATHOLOGY 160 4: 1393-1403. 2002

Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 14: 123-127. 2002

Laasanen J, Romppanen E-L, Hiltunen M, Helisalmi S, Mannermaa A, Punnonen K, Heinonen S. 2002. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia EUROPEAN JOURNAL OF HUMAN GENETICS 10: 569-573. 2002

Laasanen J, Hiltunen M, Punnonen K, Mannermaa A, Heinonen S. 2002. Fibrinogen and factor VII promoter polymorphism in women with preeclampsia. OBSTETRICS AND GYNECOLOGY 100: 317-20. 2002

Laasanen J, Heinonen S, Hiltunen M, Mannermaa A, Laakso M. 2002. Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia. EARLY HUMAN DEVELOPMENT 69: 77-82. 2002

Korhonen S, Romppanen E-L, Hiltunen M, Mannermaa A, Punnonen K, Hippeläinen M, Heinonen S. 2002. Lack of association between C-850T polymorphism of the gene encoding tumor necrosis factor-alfa and polycystic ovary syndrome. GYNECOLOGICAL ENDOCRINOLOGY 16: 271-274. 2002

Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. 2002. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. VASCULAR MEDICINE (LONDON) 7: 5-11. 2002

Hiltunen MO, Tuomisto TT, Niemi M, Bräsen JH, Rissanen TT, Törönen P, Vajanto I, Ylä-Herttuala S. 2002. Changes in gene expression in atherosclerotic plaques analyzed using DNA array. ATHEROSCLEROSIS 165: 23-32. 2002

Heiskanen J, Romppanen E-L, Hiltunen M, Iivonen S, Mannermaa A, Punnonen K, Heinonen S. 2002. Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 19 5: 220-223. 2002

Eloranta M-L, Heiskanen JTM, Hiltunen MJ, Mannermaa AJ, Punnonen KRA, Heinonen ST. 2002. Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alfa gene polymorphisms in Finnish women with obstetric cholestasis. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 104: 109-112. 2002

Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland. EUROPEAN JOURNAL OF NEUROLOGY 9 5: 479-483. 2002

Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease. NEUROSCIENCE 113 2: 301-310. 2002

Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland. NEUROLOGY 57: 1663-1668. 2001

Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin. NEUROGENETICS 3: 171-172. 2001

Hiltunen M, Soininen H. 2001. Genes, proteins and brain disease. TRENDS IN MOLECULAR MEDICINE 7 9: 382-383. 2001

Heinonen S, Korhonen S, Hippeläinen M, Hiltunen M, Mannermaa A, Saarikoski S. 2001. Apolipoprotein E alleles in women with polycystic ovary syndrome. FERTILITY AND STERILITY 75 5: 878-880. 2001

Heiskanen JT, Pirskanen MM, Hiltunen MJ, Mannermaa AJ, Punnonen KR, Heinonen ST. 2001. Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 185: 600-603. 2001

Heinonen S, Eloranta M-L, Heiskanen J, Punnonen K, Helisalmi S, Mannermaa A, Hiltunen M. 2001. Maternal susceptibility locus for obstetric cholestasis maps to chromosone region 2p13 in finnish patients. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 36: 766-770. 2001

Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. 2001. Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes. GENE THERAPY 8: 784-788. 2001

Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S. 2000. Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes. JOURNAL OF GENE MEDICINE 2: 52-60. 2000

Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. 2000. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. HUMAN GENE THERAPY 11: 263-270. 2000

Hiltunen MO. 2000. Gene Expression in Atherosclerotic Lesions and Therapeutic Strategies Using Gene Transfer. Kuopion yliopiston julkaisuja D. Lääketiede. 2000

Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods. FASEB JOURNAL 14: 2230-2236. 2000

Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. 2000. Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta. CIRCULATION 102: 2262-2268. 2000

Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. 2000. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer. VASCULAR MEDICINE (LONDON) 5: 41-48. 2000

Hiltunen M. 2000. A Molecular Genetic Study of Factors Involved in Alzheimer¿s Disease. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No. 2000

Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination? EUROPEAN JOURNAL OF HUMAN GENETICS 8: 259-266. 2000

Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E. NEUROSCIENCE LETTERS 287: 25-28. 2000

Airenne KJ, Hiltunen MO, Turunen MP, Turunen A-M, Laitinen OH, Kulomaa MS, Ylä-Herttuala S. 2000. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery. GENE THERAPY 7: 1499-1504. 2000

Turunen MP, Hiltunen MO, Ylä-Herttuala S. 1999. Gene therapy for angiogenesis, restenosis and related diseases. EXPERIMENTAL GERONTOLOGY 34: 567-574. 1999

Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. 1999. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes. GENE THERAPY 6: 6-11. 1999

Turunen M, Hiltunen M, Ylä-Herttuala S. 1999. Geeniterapia ja sen mahdollisuudet verisuonitautien hoidossa. KEMIA-KEMI 26: 186-188. 1999

Laukkanen MO, Mannermaa S, Hiltunen MO, Aittomäki S, Airenne K, Jänne J, Ylä-Herttuala S. 1999. Local hypomethylation in atherosclerosis found in rabbit ec-sod gene. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2171-2178. 1999

Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S. 1999. Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment PHARMACOLOGICAL RESEARCH 40 5: 451-457. 1999

Häkkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Ylä-Herttuala S. 1999. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2909-2917. 1999

Hiltunen MO, Niemi M, Ylä-Herttuala S. 1999. Functional genomics and DNA array techniques in atherosclerosis research. CURRENT OPINION IN LIPIDOLOGY 10: 515-519. 1999

Gough PJ, Greaves DR, Suzuki H, Hakkinen T, Hiltunen MO, Turunen M, Ylä-Herttuala S, Kodama T, Gordon S. 1999. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 461-471. 1999

Hiltunen MO, Turunen MP, Ylä-Herttuala S. 1998. Geeniterapia verisuonitautien hoidossa. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 14 4: 202-206. 1998

Hiltunen MO, Ylä-Herttuala S. 1998. Kani eläinmallina ateroskleroosin geeniterapiatutkimuksissa. KOEKUKKO. KUOPION YLIOPISTO. VALTAKUNNALLINEN KOE-ELÄINKESKUS 18 2: 28-32. 1998

Hyttinen J-M, Korhonen V-P, Hiltunen MO, Myöhänen S, Jänne J. 1998. High-level expression of bovine beta-lactoglobulin gene in transgenic mice JOURNAL OF BIOTECHNOLOGY 61: 191-198. 1998

Hiltunen MO, Alhonen L, Koistinaho J, Myöhänen S, Pääkkönen M, Marin S, Kosma V-M, Jänne J. 1997. Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. INTERNATIONAL JOURNAL OF CANCER 70: 644-648. 1997

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