Minna Kaikkonen-Määttä
Laitoksen johtaja
Professori
A.I. Virtanen -instituutti, Terveystieteiden tiedekunta
minna.kaikkonen@uef.fi | 040 355 2413
Tutkimusryhmämme selvittää sepelvaltimotaudin ja valtimonkovettumataudin molekulaarisia mekanismeja hyödyntämällä laajasti viimeisimpiä genomiikan menetelmiä.
Tutkimusryhmät
-
Itä-Suomen Genomikeskus 02.03.2009 -
-
Kardiovaskulaarinen Genomiikka (Kaikkonen tutkimu… 01.09.2015 -
Projektit
Julkaisut
113/113 kappaletta-
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells in Vitro
Selvarajan, Ilakya; Kiema, Miika; Huang, Ru Ting; Li, Jin; Zhu, Jiayu; Pölönen, Petri; Örd, Tiit; Õunap, Kadri; Godiwala, Mehvash; Golebiewski, Anna Kathryn; Ravindran, Aarthi; Mäklin, Kiira; Toropainen, Anu; Stolze, Lindsey K; Arce, Maximiliano; Magnusson, Peetra U; White, Stephen; Romanoski, Casey E; Heinäniemi, Merja; Laakkonen, Johanna P; Fang, Yun; Kaikkonen, Minna U. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 1330-1345 -
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Alireza, Z.; Maleeha, M.; Kaikkonen, M.; Fortino, V.. 2024. Journal of translational medicine. 22: . 356 -
Genetic variation drives differences in obesity-related gene regulation
Kaikkonen, Minna U. 2024. Trends in genetics. 40: 296-298 -
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P.; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U.; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi. 2024. Journal of translational medicine. 22: . 623 -
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
Schmauch, Eloi; Piening, Brian; Mohebnasab, Maedeh; Xia, Bo; Zhu, Chenchen; Stern, Jeffrey; Zhang, Weimin; Dowdell, Alexa K.; Kim, Jacqueline I.; Andrijevic, David; Khalil, Karen; Jaffe, Ian S.; Loza, Bao Li; Gragert, Loren; Camellato, Brendan R.; Oliveira, Michelli F.; O’Brien, Darragh P.; Chen, Han M.; Weldon, Elaina; Gao, Hui; Gandla, Divya; Chang, Andrew; Bhatt, Riyana; Gao, Sarah; Lin, Xiangping; Reddy, Kriyana P.; Kagermazova, Larisa; Habara, Alawi H.; Widawsky, Sophie; Liang, Feng Xia; Sa. 2024. Nature medicine. 30: 1448-1460 -
Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells
Li, Jin; Zhu, Jiayu; Gray, Olivia; Sobreira, Debora R; Wu, David; Huang, Ru-Ting; Miao, Bernadette; Sakabe, Noboru J; Krause, Matthew D; Kaikkonen, Minna U; Romanoski, Casey E; Nobrega, Marcelo A; Fang, Yun. 2024. Journal of cell biology. 223: -
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa. 2024. Redox biology. 69: -
Progression of herpesvirus infection remodels mitochondrial organization and metabolism
Leclerc, Simon; Gupta, Alka; Ruokolainen, Visa; Chen, Jian Hua; Kunnas, Kari; Ekman, Axel A; Niskanen, Henri; Belevich, Ilya; Vihinen, Helena; Turkki, Paula; Perez-Berna, Ana J; Kapishnikov, Sergey; Mäntylä, Elina; Harkiolaki, Maria; Dufour, Eric; Hytönen, Vesa; Pereiro, Eva; McEnroe, Tony; Fahy, Kenneth; Kaikkonen, Minna U; Jokitalo, Eija; Larabell, Carolyn A; Weinhardt, Venera; Mattola, Salla; Aho, Vesa; Vihinen-Ranta, Maija. 2024. PLoS pathogens. 20: -
Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations
Aherrahrou, Rédouane; Baig, Ferheen; Theofilatos, Konstantinos; Lue, Dillon; Beele, Alicia; Örd, Tiit; Kaikkonen, Minna U; Aherrahrou, Zouhair; Cheng, Qi; Ghosh, Saikat Kumar B; Karnewar, Santosh; Karnewar, Vaishnavi; Finn, Aloke V; Owens, Gary K; Joner, Michael; Mayr, Manuel; Civelek, Mete. 2024. Arteriosclerosis, thrombosis, and vascular biology. 44: 898-914 -
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease
Lee, Seung Hyuk T; Garske, Kristina M; Arasu, Uma Thanigai; Kar, Asha; Miao, Zong; Alvarez, Marcus; Koka, Amogha; Darci-Maher, Nicholas; Benhammou, Jihane N; Pan, David Z; Örd, Tiit; Kaminska, Dorota; Männistö, Ville; Heinonen, Sini; Wabitsch, Martin; Laakso, Markku; Agopian, Vatche G; Pisegna, Joseph R; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Kaikkonen, Minna U; Pajukanta, Päivi. 2024. EBioMedicine. 106: . 105232