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Minna Kaikkonen-Määttä

Minna Kaikkonen-Määttä

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Terveystieteiden tiedekunta, A. I. Virtanen -instituutti

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Tiedot Julkaisut

Tutkimusryhmämme selvittää sepelvaltimotaudin ja valtimonkovettumataudin molekulaarisia mekanismeja hyödyntämällä laajasti viimeisimpiä genomiikan menetelmiä.

Tutkimusryhmät

Itä-Suomen Genomikeskus 02.03.2009 -
Kardiovaskulaarinen Genomiikka (Kaikkonen tutkimu…
Yksisolu-genomiikan keskus 01.01.2020 -

Avainsanat

bioinformatiikka ei-koodaava RNA endoteeli epigenetiikka geenin säätely kromatiini makrofagi maksa rasvakudos sepelvaltimotauti sileä lihassolu transkriptio valtimonkovettumatauti

Julkaisut

51 kappaletta

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models
Conklin, Austin C.; Nishi, Hitoo; Schlamp, Florencia; Örd, Tiit; Õunap, Kadri; Kaikkonen, Minna U.; Fisher, Edward A.; Romanoski, Casey E.. Immunometabolism 3 3: e210022. 2021
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
Huang, Zhiqiang; Liang, Ning; Goñi, Saioa; Damdimopoulos, Anastasios; Wang, Cheng; Ballaire, Raphaelle; Jager, Jennifer; Niskanen, Henri; Han, Hongya; Jakobsson, Tomas; Bracken, Adrian P; Aouadi, Myriam; Venteclef, Nicolas; Kaikkonen, Minna U; Fan, Rongrong; Treuter, Eckardt. Molecular cell 81 5: 953-968.e9. 2021
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
Linna-Kuosmanen, Suvi; Bosch, Vanesa Tomas; Moreau, Pierre R; Bouvy-Liivrand, Maria; Niskanen, Henri; Kansanen, Emilia; Kivelä, Annukka; Hartikainen, Juha; Hippeläinen, Mikko; Kokki, Hannu; Tavi, Pasi; Levonen, Anna-Liisa; Kaikkonen, Minna U. Cardiovascular research 117 5: 1339-1357. 2021
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types
Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. Arteriosclerosis, thrombosis, and vascular biology 41 7: 2149-2167. 2021
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
Mushimiyimana, I; Niskanen. H; Beter, M; Laakkonen, JP; Kaikkonen, MU; Ylä-Herttuala, S; Laham-Karam, N. Nucleic acids research 49 14: 8078-8096. 2021
Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells
Mushimiyimana, Isidore; Tomas Bosch, Vanesa; Niskanen, Henri; Downes, Nicholas; Moreau, Pierre; Hartigan, Kiley; Ylä-Herttuala, Seppo; Laham-Karam, Nihay; Kaikkonen, Minna U.. Molecular and cellular biology 41 7: e00594-20. 2021
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease
Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. American journal of human genetics 108 3: 411-430. 2021
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
Wu, CY; Borné, Y; Gao, R; Rodriguez, ML; Roell, WC; Wilson, JM; Regmi, A; Luan, C; Aly, DM; Peter, A; Machann, J; Staiger, H; Fritsche, A; Birkenfeld, AL; Tao, R; Wagner, R; Canouil, M; Hong, MG; Schwenk, JM [incl. Laakso, M]. Nature communications 12: 6486. 2021
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci
Örd, Tiit; Õunap, Kadri; Stolze, Lindsey; Aherrahrou, Rédouane; Nurminen, Valtteri; Selvarajan, Ilakya; Toropainen, Anu; Lönnberg, Tapio; Aavik, Einari; Yla-Herttuala, Seppo; Civelek, Mete; Romanoski, Casey E; Kaikkonen, Minna U. Circulation research 129 2: 240-258. 2021
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells
Aherrahrou, Rédouane; Guo, Liang; Nagraj, Vijay Peter; Aguhob, Aaron Andrew; Hinkle, Jameson; Chen, Lisa; Soh, Joon Yuhl; Lue, Dillon; Alencar, Gabriel F; Boltjes, Arjan; van der Laan, Sander W; Farber, Emily; Fuller, Daniela; Anane-Wae, Rita; Akingbesote, Ngozi D; Manichaikul, Ani W; Ma, Lijiang; Kaikkonen, Minna U; Björkegren, Johan LM; Önengüt-Gümüscu, Suna; et al.. Circulation research 127 12: 1552-1565. 2020
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, Marie Ac; Prange, Koen Hm; Slenders, Lotte; Örd, Tiit; Elbersen, Danny; Boltjes, Arjan; de Jager, Saskia Ca; Asselbergs, Folkert W; de Borst, Gert J; Aavik, Einari; Lönnberg, Tapio; Lutgens, Esther; Glass, Christopher K; den Ruijter, Hester M; Kaikkonen, Minna U; Bot, Ilze; Slütter, Bram; van der Laan, Sander W; Ylä-Herttuala, Seppo; Mokry, Michal; et al. Circulation research 127 11: 1437-1455. 2020
Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells
Hsin-Fu Liu, Oscar; Kiema, Miika; Beter, Mustafa; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Kaikkonen, Minna U. Arteriosclerosis thrombosis and vascular biology 40: 2665-2677. 2020
Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages
Moisio, Olli; Palani, Senthil; Virta, Jenni; Elo, Petri; Liljenbäck, Heidi; Tolvanen, Tuula; Käkelä, Meeri; Miner, Maxwell G; Herre, Erika Atencio; Marjamäki, Päivi; Örd, Tiit; Heinäniemi, Merja; Kaikkonen, Minna U; Zhang, Fenghua; Srinivasarao, Madduri; Knuuti, Juhani; Low, Philip S; Saraste, Antti; Li, Xiang-Guo; Roivainen, Anne. Scientific reports 10 1: 13593. 2020
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P. Angiogenesis 2021; 24 1: 12-144. 2020
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits
Stolze, Lindsey; Conklin, Austin; Whalen, Michael; López Rodríguez, Maykel; Õunap, Kadri; Selvarajan, Ilakya; Toropainen, Anu; Örd, Tiit; Li, Jin; Eshghi, Anna; Solomon, Alice; Fang, Yun; Kaikkonen, Minna; Romanoski, Casey. American journal of human genetics 106 6: P748-763. 2020
Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA
Benhammou, Jihane N; Ko, Arthur; Alvarez, Marcus; Kaikkonen, Minna U; Rankin, Carl; Garske, Kristina M; Padua, David; Bhagat, Yash; Kaminska, Dorota; Karja, Vesa; Pihlajamäki, Jussi; Pisegna, Joseph R; Pajukanta, Päivi. Hepatology communications 3 10: 1356-1372. 2019
Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
Jauhiainen, Suvi; Laakkonen, Johanna P; Ketola, Kirsi; Toivanen, Pyry, I; Nieminen, Tina; Ninchoji, Takeshi; Levonen, Anna-Liisa; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. Frontiers in physiology 10: 224. 2019
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
Viiri, LE; Rantapero, T; Kiamehr, M; Alexanova, A; Oittinen, M; Viiri, K; Niskanen, H; Nykter, M; Kaikkonen, MU; Aalto-Setälä, K. Scientific reports 9 1: 3562. 2019
Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules
Belt, H; Koponen, JK; Kekarainen, T; Puttonen, KA; Mäkinen, PI; Niskanen, H;, Oja, J; Wirth, G; Koistinaho, J; Kaikkonen, MU; Ylä-Herttuala, S. Frontiers in cardiovascular medicine 5: 16. 2018
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
Cuartero, Sergi; Weiss, Felix D; Dharmalingam, Gopuraja; Guo, Ya; Ing-Simmons, Elizabeth; Masella, Silvia; Robles-Rebollo, Irene; Xiao, Xiaolin; Wang, Yi-Fang; Barozzi, Iros; Djeghloul, Dounia; Amano, Mariane T; Niskanen, Henri; Petretto, Enrico; Dowell, Robin D; Tachibana, Kikue; Kaikkonen, Minna U; Nasmyth, Kim A; Lenhard, Boris; Natoli, Gioacchino; et al.. Nature immunology 19 9: 932-944. 2018
Differential but Complementary HIF1[alfa] and HIF2[alfa] Transcriptional Regulation
Downes, Nicholas L; Laham-Karam, Nihay; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. MOLECULAR THERAPY 26 7: 1735-1745. 2018
Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
Gurzeler, Erika; Aavik, Einari; Laine, Anssi; Valkama, Teemu; Niskanen, Henri; Huusko, Jenni; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. Biochimica et biophysica acta: general subjects 2019; 1863 2: 481-490. 2018
Emerging Roles of Non-Coding RNA Transcription
Kaikkonen, Minna U; Adelman, Karen. Trends in biochemical sciences 43 9: 654-667. 2018
MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells
Kuosmanen, SM; Sihvola, V; Kansanen, E; Kaikkonen, MU; Levonen, AL. Redox Biology 18: 77-83. 2018
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia
López Rodríguez, Maykel; Fernandes Silva, Lilian; Vangipurapu, Jagadish; Modi, Shalem; Kuusisto, Johanna; Kaikkonen, Minna U; Laakso, Markku. Scientific Reports 8 1: 15989. 2018
Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells
Moreau, Pierre R; Örd, Tiit; Downes, Nicholas L; Niskanen, Henri; Bouvy-Liivrand, Maria; Aavik, Einari; Ylä-Herttuala, Seppo; Kaikkonen, Minna U. Frontiers in cardiovascular medicine 5 159: 12. 2018
Up-regulation of Mismatch Repair Pathway by Suicide Gene Therapy: Implications on the use of Temozolomide Treatment in Malignant Glioma
Samaranayake, Haritha Dhammika; Olsson, Venla; Kurkipuro, Jere Tuomas; Määttä, Ann-Marie; Stedt, Hanna; Kärkkäinen, Hanna-Riikka; Kaikkonen, Minna U; Taavitsainen, Miia; Vuorio, Taina; Parker, Nigel; Ylä-Herttuala, Seppo. Journal of Cancer Science & Therapy 10 8: 214-222. 2018
Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants
Tirronen, Annakaisa; Vuorio, Taina; Kettunen, Sanna; Hokkanen, Krista; Ramms, Bastian; Niskanen, Henri; Laakso, Hanne; Kaikkonen, Minna U; Jauhiainen, Matti; Gordts, Philip LSM; Ylä-Herttuala, Seppo. Arteriosclerosis thrombosis and vascular biology 38 10: 2327-2337. 2018
Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture
Bouvy-Liivrand Maria, Hernández de Sande Ana, Pölönen Petri, Mehtonen Juha, Vuorenmaa Tapio, Niskanen Henri, Sinkkonen Lasse, Unelma Kaikkonen Minna, Heinäniemi Merja. NUCLEIC ACIDS RESEARCH 45 17: 9837-9849. 2017
Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction
Kaikkonen Minna U, Halonen Paavo, Liu Oscar Hsin-Fu, Turunen Tiia A, Pajula Juho, Moreau Pierre, Selvarajan Ilakya, Tuomainen Tomi, Aavik Einari, Tavi Pasi, Ylä-Herttuala Seppo. Circulation: Cardiovascular Genetics 10 3: e001702. 2017
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. NUCLEIC ACIDS RESEARCH 2018; 46 3: 1124-1138. 2017
Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells
López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M. Genome Medicine 9: 63. 2017
Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions
Niskanen, Henri; Tuszynska, Irina; Zaborowski, Rafal; Heinäniemi, Merja; Ylä-Herttuala, Seppo; Wilczynski, Bartek; Kaikkonen, Minna U. NUCLEIC ACIDS RESEARCH 2018; 46 4: 1724-1740. 2017
SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. Cell metabolism 25 2: 412-427. 2017
Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling
Toivanen Pyry I, Nieminen Tiina, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Ylä-Herttuala Seppo. Scientific Reports 7: 5525. 2017
Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8
Laakkonen Johanna P, Lappalainen Jari P, Theelen Thomas L, Toivanen Pyry I, Nieminen Tiina, Jauhiainen Suvi,Kaikkonen Minna U, Sluimer Judith C, Ylä-Herttuala Seppo. Angiogenesis [Epub ahead of print 21 Nov 2016]: 1-16. 2016
Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-kB cistrome to reprogram the prostate cancer cell transcriptome
Malinen Marjo, Niskanen Einari A, Kaikkonen Minna U, Palvimo Jorma J. NUCLEIC ACIDS RESEARCH 45 2: 619-630. 2016
Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets
Toropainen Sari, Niskanen Einari A, Malinen Marjo, Sutinen Päivi, Kaikkonen Minna U, Palvimo Jorma J. Scientific Reports 6: 33510. 2016
Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study
Babu Mohan, Durga Devi Thota, Mäkinen Petri, Kaikkonen Minna, Lesch Hanna P, Junttila Sini, Laiho Asta, Ghimire Bishwa, Gyenesei Attila, Ylä-Herttuala Seppo. CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 117: 289-299. 2015
Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity
Nieminen Tiina, Toivanen Pyry I, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Airenne Kari J, Ylä-Herttuala Seppo. CARDIOVASCULAR RESEARCH 107 2: 267-276. 2015
Global SUMOylation on active chromatin is an acute heat stress response restricting transcription
Niskanen Einari A, Malinen Marjo, Sutinen Päivi, Toropainen Sari, Paakinaho Ville, Vihervaara Anniina, Joutsen Jenny, Kaikkonen Minna U, Sistonen Lea, Palvimo Jorma J. Genome biology 16: 153. 2015
Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR
Roberts Thomas C, Hart Jonathan R, Kaikkonen Minna U, Weinberg Marc S, Vogt Peter K, Morris Kevin V. Nature Protocols 10 8: 1198-1211. 2015
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
Shaked Iftach, Hanna Richard N, Shaked Helena, Chodaczek Grzegorz, Nowyhed Heba N, Tweet George, Tacke Robert, Basat Alp Bugra, Mikulski Zbigniew, Togher Susan, Miller Jacqueline, Blatchley Amy, Salek-Ardakani Shahram, Darvas Martin, Kaikkonen Minna U, Thomas Graham D, Lai-Wing-Sun Sonia, Rezk Ayman, Bar-Or Amit, Glass Christopher K, Bandukwala Hozefa, Hedrick Catherine C. Nature Immunology 16 12: 1228-1234. 2015
Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization
Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S. NUCLEIC ACIDS RESEARCH 42 20: 12570-84. 2014
Vespucci: a system for building annotated databases of nascent transcripts
Allison KA, Kaikkonen MU, Gaasterland T, Glass CK. NUCLEIC ACIDS RESEARCH 2013 Dec 4. [Epub ahead of print]: --. 2013
Effect of natural genetic variation on enhancer selection and function
Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD, Glass CK. NATURE (LONDON) 2013 Oct 13. [Epub ahead of print]: --. 2013
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Kaikkonen MU, Spann NJ, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass CK. MOLECULAR CELL Volume 51, Issue 3: 310-325. 2013
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. NATURE (LONDON) 2013 Jun 27;498(7455): 511-5. 2013
NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. CELL 2013 Sep 26;155(1): 200-14. 2013
25-hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. JOURNAL OF BIOLOGICAL CHEMISTRY 2013 Dec 13;288(50): 35812-23. 2013
Non-coding RNAs as regulators of gene expression and epigenetics
Kaikkonen Minna U, Lam Michael TY, Glass Christopher K. CARDIOVASCULAR RESEARCH 90: 430-440. 2011

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Näytä asetukset

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Minna Kaikkonen-Määttä

Tutkimusryhmät

Avainsanat

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells

Radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate for PET imaging of folate receptor ß-positive macrophages

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation-Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl-Coenzyme A Desaturase As an Enhancer RNA

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Differential but Complementary HIF1[alfa] and HIF2[alfa] Transcriptional Regulation

Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor

Emerging Roles of Non-Coding RNA Transcription

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells

Up-regulation of Mismatch Repair Pathway by Suicide Gene Therapy: Implications on the use of Temozolomide Treatment in Malignant Glioma

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants

Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8

Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-kB cistrome to reprogram the prostate cancer cell transcriptome

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study

Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity

Global SUMOylation on active chromatin is an acute heat stress response restricting transcription

Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

Vespucci: a system for building annotated databases of nascent transcripts

Effect of natural genetic variation on enhancer selection and function

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

25-hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

Non-coding RNAs as regulators of gene expression and epigenetics