NINA HAKULINEN

Yhteystiedot

Avainsanat

Tutkimusryhmät - UEF

• 
  Bio-orgaaninen kemia

Julkaisut

• Hameleers, Lisanne; Penttinen, Leena; Ikonen, Martina; Jaillot, Léa; Fauré, Régis; Terrapon, Nicolas; Deuss, Peter J.; Hakulinen, Nina; Master, Emma R.; Jurak, Edita. 2021. Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans Biotechnology for biofuels 14 1: 127. 2021
• Pääkkönen, Johan; Hakulinen, Nina; Andberg, Martina; Koivula, Anu; Rouvinen, Juha. 2021. Three-dimensional structure of xylonolactonase from Caulobacter crescentus: A mononuclear iron enzyme of the 6-bladed ß-propeller hydrolase family Protein science 2022; 31 2: 371-383. 2021
• Pääkkönen, Johan; Penttinen, Leena; Andberg, Martina; Koivula, Anu; Hakulinen, Nina; Rouvinen, Juha; Jänis, Janne. 2021. Xylonolactonase from Caulobacter crescentus Is a Mononuclear Nonheme Iron Hydrolase Biochemistry 60 41: 3046-3049. 2021
• Rouvinen, Juha; Andberg, Martina; Pääkkönen, Johan; Hakulinen, Nina; Koivula, Anu. 2021. Current state of and need for enzyme engineering of 2-deoxy-D-ribose 5-phosphate aldolases and its impact Applied microbiology and biotechnology 105 16-17: 6215-6228. 2021
• Tu, Tao; Wang, Zhiyun; Luo, Yan; Li, Yeqing; Su, Xiaoyun; Wang, Yuan; Zhang, Jie; Rouvinen, Juha; Yao, Bin; Hakulinen, Nina; Luo, Huiying. 2021. Structural Insights into the Mechanisms Underlying the Kinetic Stability of GH28 Endo-Polygalacturonase Journal of agricultural and food chemistry 69 2: 815-823. 2021
• Wang, S; Meng, K; Su, X; Hakulinen, N; Wang, Y; Zhang, J; Luo, H; Yao, B; Huang, H; Tu, T. 2021. Cysteine Engineering of an Endo-polygalacturonase from Talaromyces leycettanus JCM 12802 to Improve Its Thermostability Journal of agricultural and food chemistry 69 22: 6351-6359. 2021
• Ren, Y; Luo, H; Huang, H; Hakulinen, N; Wang, Y; Wang, Y; Su, X; Bai, Y; Zhang, J; Yao, B; Wang, G; Tu, T. 2020. Improving the catalytic performance of Proteinase K from Parengyodontium album for use in feather degradation International journal of biological macromolecules 154: 1586-1595. 2020
• Voutilainen, Sanni; Heinonen, Markus; Andberg, Martina; Jokinen, Emmi; Maaheimo, Hannu; Pääkkönen, Johan; Hakulinen, Nina; Rouvinen, Juha; Lähdesmäki, Harri; Kaski, Samuel; Rousu, Juho; Penttilä, Merja; Koivula, Anu. 2020. Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods Applied microbiology and biotechnology 104: 10515-10529. 2020
• Penttinen, L; Rutanen, C; Saloheimo, M; Kruus, K; Rouvinen, J; Hakulinen, N. 2018. A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes. PLOS ONE 13 5: e0196691. 2018
• Penttinen, Leena; Rutanen, Chiara; Jänis, Janne; Rouvinen, Juha; Hakulinen, Nina. 2018. Unraveling substrate specificity and catalytic promiscuity of Aspergillus oryzae catechol oxidase CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 19 22: 2348-2352. 2018
• Rahman, MM; Andberg, M; Koivula, A; Rouvinen, J; Hakulinen, N. 2018. The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family. Scientific Reports 8 1: 865. 2018
• Chu Yindi, Tu Tao, Penttinen Leena, Xue Xianli, Wang Xiaoyu, Yi Zhuolin, Gong Li, Rouvinen Juha, Luo Huiying, Hakulinen Nina, Yao Bin, Su Xiaoyun. 2017. Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose. JOURNAL OF BIOLOGICAL CHEMISTRY 292 47: 19315-19327. 2017
• Rahman Mohammad Mubinur, Andberg Martina, Thangaraj Senthil Kumar, Parkkinen Tarja, Penttilä Merja, Jänis Janne, Koivula Anu, Rouvinen Juha, Hakulinen Nina. 2017. The Crystal Structure of a Bacterial L-Arabinonate Dehydratase Contains a [2Fe-2S] Cluster. ACS Chemical Biology 12 7: 1919-1927. 2017
• Andberg M, Aro-Kärkkäinen N, Carlson P, Oja M, Bozonnet S, Toivari M, Hakulinen N, O'Donohue M, Penttilä M, Koivula A. 2016. Characterization and mutagenesis of two novel iron - sulphur cluster pentonate dehydratases. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100 17: 7549-7563. 2016
• Rahman Mohammad Mubinur, Andberg Martina, Koivula Aanu, Rouvinen Juha, Hakulinen Nina. 2016. Crystallization and X-ray diffraction analysis of an L-arabinonate dehydratase from Rhizobium leguminosarum bv. trifolii and a D-xylonate dehydratase from Caulobacter crescentus. Acta Crystallographica Section F 72 8: 604-608. 2016
• Hakulinen Nina, Rouvinen Juha. 2015. Three-dimensional structures of laccases. CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 72 5: 857-868. 2015
• Taberman Helena, Andberg Martina, Koivula Anu, Hakulinen Nina, Penttilä Merja, Rouvinen Juha, Parkkinen Tarja. 2015. Structure and function of Caulobacter crescentus aldose-aldose oxidoreductase. BIOCHEMICAL JOURNAL 472 3: 297-307. 2015
• Taberman H, Andberg A, Parkkinen T, Jänis J, Penttilä M, Hakulinen N, Koivula A, Rouvinen J. 2014. Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-D-galactarate dehydratase. BIOCHEMISTRY 53 51: 8052-8060. 2014
• Taberman H, Andberg M, Parkkinen Y, Richard P, Hakulinen N, Koivula A, Rouvinen J. 2014. Purification, crystallization and preliminary X-ray diffraction analysis of a novel keto-deoxy-D-galactarate (KDG) dehydratase from Agrobacterium tumefaciens. Acta Crystallographica Section F 70: 49-52. 2014
• Hakulinen N, Gasparetti C, Kaljunen H, Kruus K, Rouvinen J. 2013. The crystal structure of an extracellular catechol oxidase from the ascomycete fungus Aspergillus oryzae. Journal of biological inorganic chemistry 18: 917-929. 2013
• Maksimainen M, Paavilainen S, Hakulinen N, Rouvinen J. 2012. Structural analysis, enzymatic characterization, and catalytic mechanisms of beta-galactosidase from Bacillus circulans sp alkalophilus. FEBS JOURNAL 279: 1788-1798. 2012
• Lehmuskero Anni, Hakulinen Nina, Vahimaa Pasi, Nadrian C. Seeman. 2011. Polarization effects of self-assembled DNA crystals. Teoksessa: (toim.), Optics Days 2011, Book of Abstracts. ss. 84. 2011
• Maksimainen M, Hakulinen N, Kallio JM, Timoharju T, Turunen O & Rouvinen J.. 2011. Crystal structures of Trichoderma reesei β-galactosidase reveal conformational changes in the active site JOURNAL OF STRUCTURAL BIOLOGY 174: 156-163. 2011
• Kaljunen H, Gasparetti C, Kruus K, Rouvinen J & Hakulinen N. 2011. Crystallization and preliminary X-ray analysis of Aspergillus oryzae catechol oxidase Acta Crystallographica Section F 67: 672-674. 2011
• Lehmuskero Anni, Hakulinen Nina, Lajunen Hanna, Zheng Jianping, Sha Ruojie, Bai Benfeng, Huang Lingling, Turunen Jari, Vahimaa Pasi, Seeman Nadrian C.. 2011. Linear birefringence magnitude of artificial self-assembled DNA crystals. Optical Materials Express 1 5: 936-942. 2011
• Kallio JP, Rouvinen J, Kruus K & Hakulinen N. 2011. Probing the dioxygen route in Melanocarpus albomyces laccase with pressurised xenon-gas BIOCHEMISTRY 50: 4396-4398. 2011
• Kallio JP, Gasparetti C, Andberg M, Boer H, Koivula A, Kruus K, Rouvinen J & Hakulinen N. 2011. Crystal structure of an ascomycete fungal laccase from Thielavia arenaria: Common features of asco-laccases FEBS JOURNAL 278: 2283-2295. 2011
• Andberg, M., Hakulinen, N., Auer, S., Saloheimo, M., Koivula, A., Rouvinen, J. and Kruus, K.. 2009. Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure. FEBS Journal 276: 6285-6300. 2009
• Kallio JM, Hakulinen N, Kallio JP, Niemi MH, Kärkkäinen S & Rouvinen J. 2009. The contribution of polystyrene nanospheres towards the crystallization of proteins. PLOS ONE [ONLINE] 4 1: e4198. 2009
• Kallio, J. P., Auer, S., Jänis, J., Andberg, M., Kruus, K., Rouvinen, J., Koivula, A., and Hakulinen, N. 2009. Structure-function studies of a Melanocarpus albomyces laccase suggest a pathway for oxidation of phenolic compounds J. Mol. Biol. 392: 895-909. 2009
• Kallio, J. P., Jänis, J., Nyyssölä, A., Hakulinen, N., and Rouvinen, J.. 2009. Preliminary X-ray analysis of twinned crystals of sarcosine dimethylglycine methyltransferase from Halorhodospira halochoris. Acta Cryst. F65: 805-808. 2009
• Maksimainen M, Timoharju T, Kallio JM, Hakulinen N, Turunen O & Rouvinen J. 2009. Crystallization and preliminary diffractoin analysis of a b-galactosidase from Trichoderma reesei. Acta Cryst. F65: 767-769. 2009
• Merja Niemi, Janne Jänis, Sirpa Jylhä, Johanna M. Kallio, Nina Hakulinen, Marja-Leena Laukkanen, Kristiina Takkinen and Juha Rouvinen. 2008. Characterization and crystallization of a recombinant IgE Fab fragment in complex with the bovine b- lactoglobulin allergen. Acta Crystallographica Section F F64: 25-28. 2008
• N. Hakulinen, M. Andberg, J. Kallio, A. Koivula, K. Kruus, J. Rouvinen. 2008. A near-atomic resolution structure of a Melanocapus albomyces laccase.. Journal of Structural Biology 162: 29-39. 2008
• Niemi M.;Jylhä S.;Laukkanen M-L.;Söderlund H.;Mäkinen-Kiljunen S.;Kallio J.;Hakulinen N.;Haahtela T.;Takkinen K.;Rouvinen J.. 2007. Molecular interactions between a recombinant IgE antibody and the b- lactoglobulin allergen. Structure 15: 1413-1421. 2007
• Hakulinen Nina;Kruus Kristiina;Koivula Anu;Rouvinen Juha. 2006. A crystallographic and spectroscopic study on the effect of X-ray radiation on the crystal structure of Melanocarpus albomyces laccase. Biochemical Biophysical Research Communications 350: 929-934. 2006
• Jänis J;Hakanpää J;Hakulinen N;Ibatullin FM;Hoxha A;Derrick PJ;Rouvinen J;Vainiotalo P. 2005. Determination of Thiooxylo-oligosaccharide Binding to Family 11 Xylanases Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and X-Ray Crystallography. FEBS Journal 272: 2317-2333. 2005
• Hakanpää J;Parkkinen T;Hakulinen N;Linder M & Rouvinen J. 2004. Crystallization and preliminary X-ray characterization of Trichoderma reesei hydrophobin HFBII. Acta Cryst. D 60: 163-165. 2004
• Parkkinen T;Hakulinen N;Tenkanen M;Siika-aho M & Rouvinen J. 2004. Crystallization and preliminary X-ray analysis of a novel Trichoderma reesei xylanase IV belonging to glycoside hydrolase family 5. Acta Cryst. D 60: 542-544. 2004
• Hakulinen N;Turunen O;Jänis J;Leisola M & Rouvinen J:. 2003. Three-dimensional structures of thermophilic beta-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa. Eur. J. Biochem. 270: 1399-1412. 2003
• Hakulinen N;Kiiskinen L-L;Kruus K;Saloheimo M;Paananen A;Koivula A;Rouvinen J. 2002. Crystal structure of a laccase from Melanocarpus albomyces with an intact trinuclear copper site. Nature structural biology 9 8: 601-605. 2002
• Hakulinen N;Paavilainen S;Korpela T;Rouvinen J. 2000. The crystal structure of beta-glucosidase from Bacillus circulans sp. alkalophilus: ability to form polymeric assemblies. Journal of Structural Biology 129: 69-79. 2000
• Hakulinen N;Tenkanen M;Rouvinen J. 2000. Three-dimensional structure of the catalytic core of acetylxylan esterase from Trichoderma reesei: insights into the deacetylation mechanism. Journal of Structural Biology 132: 180-190. 2000
• Hakulinen N;Tenkanen M;Rouvinen J. 1998. Crystallization and preliminary X-ray diffraction studies of the catalytic core of acetyl xylan esterase from Trichoderma reesei. Acta Cryst. D 54: 430-432. 1998