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Päivi Hartikainen

Päivi Hartikainen

Vieraileva tutkija

Kliinisen lääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta

paivi.hartikainen@uef.fi

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55/55 kappaletta

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients
Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease. 72: 127-137
Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion
Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology. 2020; 267: 76-86
Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis
Cajanus, A; Hall, A; Koikkalainen, J; Solje, E; Tolonen, A; Urhemaa, T; Liu, Y; Haanpää, RM; Hartikainen, P; Helisalmi, S; Korhonen, V; Rueckert, D; Hasselbalch, S; Waldemar, G; Mecocci, P; Vanninen, R; van Gils, M; Soininen, H; Lötjönen, J; Remes, AM. 2018. Dementia and geriatric cognitive disorders extra. 8: 51-59
Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration
Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Journal of Alzheimer's disease. 62: 789-794
The association between frontotemporal lobar degeneration and bullous pemphigoid
Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. Journal of Alzheimer's disease. 66: 743-750
Alpha-synucleinopathies
Alafuzoff I, Hartikainen P. Teoksessa: Kovacs Gabor G, Alafuzoff Irina(toim.) , 2017. Handbook of Clinical Neurology. Neuropathology. s. 339-353. Elsevier
Sequence of cardiovascular autonomic alterations after fingolimod initiation
Simula Sakari, Laitinen Tomi P, Laitinen Tiina M, Hartikainen Päivi, Hartikainen Juha EK. 2017. Annals of noninvasive electrocardiology. 22: e124431-5
Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis
Simula Sakari, Laitinen Tomi, Laitinen Tiina M, Tarkiainen Tuula, Hartikainen Päivi, Hartikainen Juha EK. 2016. Multiple sclerosis. 22: 1080-1085
Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease
Kokkonen N, Herukka SK, Huilaja L, Kokki M, Koivisto AM, Hartikainen P, Remes AM, Tasanen K. 2016. Journal of investigative dermatology. 2017; 137: 71-76
Modulation of sphingosine receptors influences circadian pattern of cardiac autonomic regulation
Simula Sakari, Laitinen Tomi P, Laitinen Tiina M, Hartikainen Päivi, Hartikainen Juha EK. 2016. Physiological reports. 4: e12870
Mortality after stroke in patients with paroxysmal and chronic atrial fibrillation - The FibStroke study
Palomäki Antti, Kiviniemi Tuomas, Mustonen Pirjo, Odei Casey, Hartikainen Juha EK, Nuotio Ilpo, Ylitalo Antti, Hartikainen Päivi, Biancari Fausto, Airaksinen KE Juhani. 2016. International journal of cardiology. 2017; 227: 869-874
Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion
Kämäläinen A, Herukka S-K, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM. 2015. Dementia and geriatric cognitive disorders. 39: 287-293
Effects of three months fingolimod therapy of heart rate
Simula Sakari, Laitinen Tomi, Laitinen Tiina M, Tarkiainen Tuuula, Hartikainen Juha EK, Hartikainen Päivi. 2015. Journal of neuroimmune pharmacology. epub ahead of print 20 Jun 2015: -
TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions
Gallagher Michael D, Suh Eunran, Grossman Murray, Elman Lauren, McCluskey Leo, Van Swieten John C., Al-Sarraj Safa, Neumann Manuela, Gelpi Ellen, Ghetti Bernardino, Rohrer Jonathan D., Halliday Glenda, Van Broeckhoven Christine, Seilhean Danielle, Shaw Pamela J., Frosch Matthew P., Alafuzoff Irina, Antonell Anna, Bogdanovic Nenad, Brooks William et al. (incl. Hartikainen Päivi). 2014. Acta neuropathologica. 127: 407-418
The C90RF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation
Solje Eino, Hartikainen Päivi, Valori Miko, Vanninen Ritva, Tiihonen Jari, Hakola Panu, Tienari Pentti J, Remes Anne M. 2014. Neurobiology of aging. 35: 1780.e13-1780.e17
Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's Disease and mild cognitive impairment
Munoz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Journal of Alzheimer's disease. 35: 727-739
Lewynkappaletauti
Hartikainen P. Teoksessa: Hallikainen M, Mönkäre R, Nukari T, Folder M(toim.) , 2013. Muistisairaan kuntouttava hoito. s. 288-292. Kustannus Oy Duodecim
Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's Disease
Hartikainen P, Räsänen J, Julkunen V, Niskanen E, Hallikainen M, Kivipelto M, Vanninen R, Remes AM, Soininen H. 2012. Journal of Alzheimer's disease. 30: 857-874
Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
Munoz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka S-K, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H. 2012. PLoS ONE. 7: e52531
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions
Hartikainen PH, Pikkarainen M, Hänninen T, Soininen H, Alafuzoff I. 2012. Neuropathology. 32: 60-68
Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I. 2011. Cerebellum. 10: 720-731
Longitudinal changes of CSF biomarkers in Alzheimer's Disease
Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Journal of Alzheimer's disease. 25: 583-594
Common variants at 7p21 are associated with fronto-temporal lobar degeneration with TDP-43 inclusions
Van Deerlin VM, Sleiman PMA, Martinez-Lage M et al. 2010. Nature genetics. 42: 234-239
Muistisairaudet
Erkinjuntti T, Rinne J & Soininen H. 2010. . . WS Bookwell Oy
Ubiquitinated p62-positive, TDP-43-negative inclusions in cerebellum in frontotemporal lobar degeneration with TAR DNA binding protein 43
Pikkarainen M, Hartikainen P & Alafuzoff I. 2010. Neuropathology. 30: 197-199
Cerebrospinal fluid {beta}-amyloid 42 and Tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
Tapiola T, Alafuzoff I, Herukka S-K, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2009. Archives of neurology. 66: 382-389
Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease
Seppänen A, Pikkarainen M, Hartikainen P, Hofmann SC, Majamaa K, Alafuzoff I. 2009. Brain research. 1247: 171-177
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry
Pikkarainen M, Hartikainen P, Alafuzoff I. 2008. Journal of neuropathology and experimental neurology. 67: 280-298
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala E-L, Vainio P, Vanninen R, Partanen K, Soininen H, Pennanen C, Kivipelto M, Tuomainen S, Hänninen T, Hallikainen M, Vanhanen M. 2004. Neurobiology of aging. 25: 303-310
Mitochondrial DNA polymorphisms as risk factors for Parkinson¿s disease and Parkinson¿s disease dementia
Autere J, Moilanen JS, Finnilä S, Soininen H, Mannermaa A, Hartikainen P, Hallikainen M, Majamaa K, Soininen H. 2004. Human genetics. 115: 29-35
Clinical and radiographic risk factors for operative stroke and death in the European Carotid Surgery Trial
Bond R, Narayan SK, Rothwell PM, Warlow CP, on behalf of the European Carotid Surgery Trialists¿ Collaborative Group, Sivenius J, Hartikainen P, Oksala I. 2002. European journal of vascular and endovascular surgery. 23: 108-116
Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke
Cunningham EJ, Bond R, Mehta Z, Mayberg MR, Warlow CP, Rothwell PM, the European Carotid Surgery Trialists¿ Collaborative Group, Sivenius J, Hartikainen P, Oksala I. 2002. Stroke. 33: 2658-2663
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland
Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. European journal of neurology. 9: 479-483
Variation in surgical and anaesthetic technique and associations with operative risk in the European Carotid Surgery Trial: Implications for trials of ancillary techniques
Bond R, Warlow CP, Naylor AR, Rothwell PM, on behalf of the European Carotid Surgery Trialists¿ Collavorative Group, Sivenius J, Hartikainen P, Oksala I. 2002. European journal of vascular and endovascular surgery. 23: 117-126
Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNA
Finnilä S, Autere J, Lehtovirta M, Hartikainen P, Mannermaa A, Soininen H, Majamaa K. 2001. Journal of medical genetics
A longitudinal quantitative EEG study of Alzheimer¿s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Hiltunen J, Helisalmi S, Hartikainen P, Riekkinen P Sr, Soininen H. 2000. Dementia and geriatric cognitive disorders. 11: 29-35
Heterogeneity of cerebral blood flow: a fractal approach
Kuikka JT, Hartikainen P. 2000. Nuklearmedizin-nuclear medicine. 39: 37-42
Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and risk of ischemic stroke in oatients with symptomatic carotid stenosis
Rothwell PM, Gibson R, Warlow CP, on behalf of the European Carotid Surgery Trialists¿ Collaborative Group, Hartikainen P, Koivisto K, Oksala I, Riekkinen P, Sivenius J. 2000. Stroke. 31: 615-621
Low risk of ischemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis. Cerebral protection due to low poststenotic flow?
Rothwell PM, Warlow CP, on behalf of the European Carotid Surgery Trialists¿ Collaborative Group, Hartikainen P, Koivisto K, Oksala I, Riekkinen P, Sivenius J. 2000. Stroke. 31: 622-630
Interpretation of operative risks of individual surgeons
Rothwell PM, Warlow CP, on behalf of the European Carotid Surgery Trialists` Collaborative Group, Hartikainen P, Koivisto K, Oksala I, Riekkinen P, Sivenius J. 1999. The Lancet
Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study
Rothwell PM, Warlow CP, on behalf of the European Carotid Surgery Trialists¿ Collaborative Group, Hartikainen P, Riekkinen P, Sivenius J. 1999. The Lancet. 353: 2105-2110
Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient
Alafuzoff I, Hartikainen P, Hanninen T, Partanen K, Kuikka J, Syrjänen K, Naukkarinen A, Soininen H. 1999. Clinical neuropathology. 18: 113-123
Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry. 64: 742-746
Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST)
European Carotid Surgery Trialists¿ Collaborative Group, Hartikainen P, Koivisto K, Oksala I, Riekkinen P, Sivenius J. 1998. The Lancet. 351: 1379-1387
Subclinical cerebral complications after coronary artery bypass grafting
Vanninen R, Äikiä M, Könönen M, Partanen K, Tulla H, Hartikainen P, Partanen J, Manninen H, Enberg P, Hippeläinen M. 1998. Archives of neurology. 55: 618-627
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ Sr. 1996. Neurology. 46: 413-419
Endarterectomy for moderate symptomatic carotid stenosis: interim results from the MRC european carotid surgery trial
European Carotid Surgery Trialists` Collaborative Group, Hartikainen P, Koivisto K, Oksala I, Riekkinen P, Sivenius J. 1996. The Lancet. 347: 1591-1593
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele
Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynänen M, Kuikka J, Hartikainen P, Riekkinen PJ Sr. 1996. Journal of neurology neurosurgery and psychiatry. 60: 644-649
Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer`s disease patiens
Helkala E-L, Hänninen T, Könönen M, Hartikainen P, Partanen J, Partanen K, Vainio P, Hallikainen M, Laakso MP, Soininen H, Riekkinen P Sr. 1996. Behavioral neuroscience. 110: 1235-1243
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Soininen H, Helisalmi S, Mannermaa A, Ryynänen M, Hartikainen P, Riekkinen P Sr. 1996. Neurobiology of aging. 17: 523-526
Imaging of serotonin and dopamine transporters in the living human brain
Kuikka JT, Tiihonen J, Bergström KA, Karhu J, Hartikainen P, Viinamäki H, Länsimies E, Lehtonen J, Hakola P. 1995. European journal of nuclear medicine and molecular imaging. 22: 346-350
Regional cerebral blood flow measured by 99mTC-HMPAO SPECT differs in subgroups of Alzheimer's disease
Soininen H, Helkala E-L, Kuikka J, Hartikainen P, Lehtovirta M, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 95-109
Volumes of hippocampus and amygdala in the magnetic resonance imaging based diagnosis of early Alzheimer's disease
Laakso MP, Soininen H, Helkala E-L, Hartikainen P, Partanen K, Vainio P, Riekkinen PJ Sr. Teoksessa: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM(toim.) , 1995. Research Advances in Alzheimer's Disease and Related Disorders. s. 181-188. John Wiley
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes
Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Partanen K, Ryynänen M, Vainio P, Hartikainen P, Riekkinen PJ Sr. 1995. Neuroscience. 67: 65-72
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions
Laakso MP, Soininen H, Partanen K, Helkala E-L, Hartikainen P, Vainio P, Hallikainen M, Hänninen T, Riekkinen PJ Sr. 1995. Journal of neural transmission. 9: 73-86

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Näytä asetukset

{title} {title} {title}

Tarkenna hakuasi

Päivi Hartikainen

Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration

The association between frontotemporal lobar degeneration and bullous pemphigoid

Alpha-synucleinopathies

Sequence of cardiovascular autonomic alterations after fingolimod initiation

Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis

Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease

Modulation of sphingosine receptors influences circadian pattern of cardiac autonomic regulation

Mortality after stroke in patients with paroxysmal and chronic atrial fibrillation - The FibStroke study

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion

Effects of three months fingolimod therapy of heart rate

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

The C90RF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation

Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's Disease and mild cognitive impairment

Lewynkappaletauti

Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's Disease

Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry

Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions

Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar Ataxia as assessed by p62/Sequestosome immunohistochemistry

Longitudinal changes of CSF biomarkers in Alzheimer's Disease

Common variants at 7p21 are associated with fronto-temporal lobar degeneration with TDP-43 inclusions

Muistisairaudet

Ubiquitinated p62-positive, TDP-43-negative inclusions in cerebellum in frontotemporal lobar degeneration with TAR DNA binding protein 43

Cerebrospinal fluid {beta}-amyloid 42 and Tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain

Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

Mitochondrial DNA polymorphisms as risk factors for Parkinson¿s disease and Parkinson¿s disease dementia

Clinical and radiographic risk factors for operative stroke and death in the European Carotid Surgery Trial

Long-term durability of carotid endarterectomy for symptomatic stenosis and risk factors for late postoperative stroke

Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland

Variation in surgical and anaesthetic technique and associations with operative risk in the European Carotid Surgery Trial: Implications for trials of ancillary techniques

Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNA

A longitudinal quantitative EEG study of Alzheimer¿s disease: relation to apolipoprotein E polymorphism

Heterogeneity of cerebral blood flow: a fractal approach

Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and risk of ischemic stroke in oatients with symptomatic carotid stenosis

Low risk of ischemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis. Cerebral protection due to low poststenotic flow?

Interpretation of operative risks of individual surgeons

Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study

Rapidly progressive multifocal leukoencephalopathy with substantial cell-mediated inflammatory response and with cognitive decline of non-Alzheimer type in a 75-year-old female patient

Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism

Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST)

Subclinical cerebral complications after coronary artery bypass grafting

Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism

Endarterectomy for moderate symptomatic carotid stenosis: interim results from the MRC european carotid surgery trial

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele

Slow-wave activity in the spectral analysis of the electroencephalogram and volumes of hippocampus in subgroups of Alzheimer`s disease patiens

Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism

Imaging of serotonin and dopamine transporters in the living human brain

Regional cerebral blood flow measured by 99mTC-HMPAO SPECT differs in subgroups of Alzheimer's disease

Volumes of hippocampus and amygdala in the magnetic resonance imaging based diagnosis of early Alzheimer's disease

Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes

Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions