Pirkka Kirjavainen

Continuous rather than solely early farm exposure protect from hay fever development

Pechlivanis, Sonali; Depner, Martin; Kirjavainen, Pirkka V; Roduit, Caroline; Täubel, Martin; Frei, Remo; Skevaki, Chrysanthi; Hose, Alexander; Barnig, Cindy; Schmausser-Hechfellner, Elisabeth; Ege, Markus J; Schaub, Bianca; Divaret-Chauveau, Amandine; Lauener, Roger; Karvonen, Anne M; Pekkanen, Juha; Riedler, Josef; Illi, Sabina; von Mutius, Erika. 2023. Journal of allergy and clinical immunology : in practice. 11: 591-601

Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Lukkarinen, Minna; Kirjavainen, Pirkka V; Backman, Katri; Gonzales-Inca, Carlos; Hickman, Brandon; Kallio, Sampo; Karlsson, Hasse; Karlsson, Linnea; Keski-Nisula, Leea; Korhonen, Laura S; Korpela, Katri; Kuitunen, Mikael; Kukkonen, Anna Kaarina; Kayhko, Niina; Lagstrom, Hanna; Lukkarinen, Heikki; Peltola, Ville; Pentti, Jaana; Salonen, Anne; Savilahti, Erkki; Tuoresmaki, Pauli; Taubel, Martin; Vahtera, Jussi; de Vos, Willem M; Pekkanen, Juha; Karvonen, Anne M. 2023. Pediatric allergy and immunology. 34:

Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study

Täubel, Martin; Jalanka, Jonna; Kirjavainen, Pirkka V; Tuoresmäki, Pauli; Hyvärinen, Anne; Skevaki, Chrysanthi; Piippo-Savolainen, Eija; Pekkanen, Juha; Karvonen, Anne M. 2023. Annals of the American Thoracic Society. 20: 1456-1464

Kotipölystä sekvensoitujen sienten yhteys astmaan - tuloksia suomalaisesta syntymäkohorttitutkimuksesta

Karvonen, Anne M; Täubel, Martin; Jalanka, Jonna; Kirjavainen, Pirkka V; Tuoresmäki, Pauli; Piippo-Savolainen, Eija; Hyvärinen, Anne; Pekkanen, Juha. Teoksessa: Ahola, Mervi; Merikari, Anna(toim.) , 2023. Sisäilmastoseminaari 2023. s. 343-348. Siy sisäilmatieto oy

Associations between residential greenness, indoor microbiota and risk of developing allergic rhinitis

Tischer, Christina; Zacheus, Teemu; Täubel, Martin; Gonzales-Inca, Carlos; Jalanka, Jonna; Tuoresmäki, Pauli; Jayaprakash, Balamuralikrishna; Vahtera, Jussi; Hyvärinen, Anne; Pekkanen, Juha; Karvonen, Anne M.; Kirjavainen, Pirkka V. 2022.

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding

Taft, Diana H.; Lewis, Zachery T.; Nguyen, Nhu; Ho, Steve; Masarweh, Chad; Dunne-Castagna, Vanessa; Tancredi, Daniel J.; Huda, M. Nazmul; Stephensen, Charles B.; Hinde, Katie; von Mutius, Erika; Kirjavainen, Pirkka V.; Dalphin, Jean-Charles; Lauener, Roger; Riedler, Josef; Smilowitz, Jennifer T.; German, J. Bruce; Morrow, Ardythe L.; Mills, David A.. 2022. Nutrients. 14:

Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants

Hickman, Brandon; Kirjavainen, Pirkka V.; Täubel, Martin; de Vos, Willem M.; Salonen, Anne; Korpela, Katri. 2022. Frontiers in microbiology. 13:

Early‐life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort

Tischer, Christina; Täubel, Martin; Kirjavainen, Pirkka V; Depner, Martin; Hyvärinen, Anne; Piippo‐Savolainen, Eija; Pekkanen, Juha; Karvonen, Anne M. 2022. Pediatric allergy and immunology. 33:

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Illi, S; Depner, M; Pfefferle, PI; Renz, H; Roduit, C; Taft, DH; Kalanetra, KM; Mills, DA; Farquharson, FM; Louis, P; Schmausser-Hechfellner, E; Divaret-Chauveau, A; Lauener, R; Karvonen, AM; Pekkanen, J; Kirjavainen, PV; Roponen, M; Riedler, J; Kabesch, M; Schaub, B; von Mutius, E; PASTURE Study Group. 2022. American journal of respiratory and critical care medicine. 205: 641-650

Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention

Tischer, Christina; Kirjavainen, Pirkka; Matterne, Uwe; Tempes, Jana; Willeke, Kristina; Keil, Thomas; Apfelbacher, Christian; Täubel, Martin. 2022. Science of the total environment. 821:

Role of house dust microbiota in health benefits of dog keeping

Mäki, Jenni M; Kirjavainen, Pirkka V; Täubel, Martin; Piippo-Savolainen, Eija; Backman, Katri; Pekkanen, Juha; Karvonen, Anne M. 2022.

The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood

Fong, Fiona Long Yan; El-Nezami, Hani; Mykkänen, Otto; Kirjavainen, Pirkka V.. 2022. Frontiers in nutrition. 9: . 73298

The Microbiome as a Gateway to Prevention of Allergic Disease Development

Kloepfer, Kirsten M; McCauley, Kathryn E; Kirjavainen, Pirkka V. 2022. Journal of allergy and clinical immunology : in practice. 10: 2195-2204

Associations between dog keeping and indoor dust microbiota

Mäki, Jenni M; Kirjavainen, Pirkka V; Taubel, Martin; Piippo-Savolainen, Eija; Backman, Katri; Hyvärinen, Anne; Tuoresmäki, Pauli; Jayaprakash, Balamuralikrishna; Heinrich, Joachim; Herberth, Gunda; Standl, Marie; Pekkanen, Juha; Karvonen, Anne M. 2021. Scientific reports. 11: 5341

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha. 2021. Pediatric allergy and immunology. 32: 1226-1237

Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts

Hose, Alexander J; Genuneit, Jon; Pagani, Giulia; Roduit, Caroline; Schmauaer-Hechfellner, Elisabeth; Karvonen, Anne M; Kirjavainen, Pirkka V; Roduit, Caroline; Genuneit, Jon; Schmaußer-Hechfellner, Elisabeth; Depner, Martin; Frei, Remo; Lauener, Roger; Riedler, Josef; Schaub, Bianca; Fuchs, Oliver; von Mutius, Erika; Divaret-Chauveau, Amandine; Pekkanen, Juha; Ege, Markus J. 2021. Frontiers in immunology. 12: 1-14

Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts

Hyytiäinen, Heidi; Kirjavainen, Pirkka V; Täubel, Martin; Tuoresmäki, Pauli; Casas, Lidia; Heinrich, Joachim; Herberth, Gunda; Standl, Marie; Renz, Harald; Piippo-Savolainen, Eija; Hyvärinen, Anne; Pekkanen, Juha; Karvonen, Anne M. 2021. Environmental research. 196: 110835

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Depner, Martin; Taft, Diana Hazard; Kirjavainen, Pirkka V; Kalanetra, Karen M; Karvonen, Anne M; Peschel, Stefanie; Schmausser-Hechfellner, Elisabeth; Roduit, Caroline; Frei, Remo; Lauener, Roger; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Riedler, Josef; Roponen, Marjut; Kabesch, Michael; Renz, Harald; Pekkanen, Juha; Farquharson, Freda M; Louis, Petra; Mills, David A. et al.. 2020. Nature medicine. 26: 1766-1775

Reply

Karvonen, Anne; Kirjavainen, Pirkka; Täubel, Martin; Pekkanen, Juha. 2020. Journal of allergy and clinical immunology. 145: 1307-1308

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Keski-Rahkonen, Pekka; Kolehmainen, Marjukka; Lappi, Jenni; Micard, Valerie; Jokkala, Jenna; Rosa-Sibakov, Natalia; Pihlajamäki, Jussi; Kirjavainen, Pirkka V; Mykkänen, Hannu; Poutanen, Kaisa; Gunter, Marc J; Scalbert, Augustin; Hanhineva, Kati. 2019. American journal of clinical nutrition. 109: 1630-1639

Early life home microbiome and hyperactivity/inattention in school-age children

Casas, L; Karvonen, AM; Kirjavainen, PV; Täubel, M; Hyytiäinen, H; Jayaprakash, B; Lehmann, I; Standl, M; Pekkanen, J; Heinrich, J. 2019. Scientific reports. 9: 17355

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Nature medicine. 25: 1089-1095

Indoor Bacterial Microbiota and the Development of Asthma by 10.5 years of age

Karvonen, AM; Kirjavainen, PV; Täubel, M; Jayaprakash, B; Adams, RI; Sordillo, JE; Gold, DR; Hyvärinen, A; Remes, S; von Mutius, E; Pekkanen, J. 2019. Journal of allergy and clinical immunology. 144: 1402-1410

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

Kirjavainen, PV; Karvonen, AM; Adams, RI; Täubel, M; Roponen, M; Tuoresmäki, P; Loss, G; Jayaprakash, B; Depner, M; Ege, MJ; Renz, H; Pfefferle, PI; Schaub, B; Lauener, R; Hyvärinen, A; Knight, R; Heederik, DJJ; von Mutius, E; Pekkanen, J. 2019. Duodecim. 135: 1309

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Brick, Tabea; Hose, Alexander; Wawretzka, Katharina; von Mutius, Erika; Roduit, Caroline; Lauener, Roger; Riedler, Josef; Karvonen, Anne M; Pekkanen, Juha; Divaret-Chauveau, Amandine; Dalphin, Jean-Charles; Ege, Markus J; PASTURE study group (incl. Roponen, Marjut; Hirvonen, Maija-Riitta; Kirjavainen, Pirkka Viljami). 2019. Pediatric allergy and immunology. 30: 795-802

Crawling-induced floor dust resuspension affects the microbiota of the infant breathing zone

Hyytiäinen, Heidi K; Jayaprakash, Balamuralikrishna; Kirjavainen, Pirkka V; Saari, Sampo E; Holopainen, Rauno; Keskinen, Jorma; Hämeri, Kaarle; Hyvärinen, Anne; Boor, Brandon E; Täubel, Martin. 2018. Microbiome. 6: 25

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

Karvonen, AM; Tischer, C; Kirjavainen, PV; Roponen, M; Hyvärinen, A; Illi, S; Mustonen, K; Pfefferle, PI; Renz, H; Remes, S; Schaub, B; von Mutius, E; Pekkanen, J. 2018. Indoor air. 28: 450-458

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Roduit, C; Frei, R; Ferstl, R; Loeliger, S; Westermann, P; Rhyner, C; Schiavi, E; Barcik, W; Rodriguez-Perez, N; Wawrzyniak, M; Chassard, C; Lacroix, C; Schmausser-Hechfellner, E; Depner, M; von Mutius, E; Braun-Fahrländer, C; Karvonen, A; Kirjavainen, P; Pekkanen, J; Dalphin, JC; et al. 2018. Allergy. 2019; 74: 799-809

Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

Fong Fiona Long Yan, Kirjavainen Pirkka, Wong Victoria Ho Yee, El-Nezami Hani. 2015. Journal of functional foods. 13: 71-79

Microbial secondary metabolites in homes in association with moisture damage and asthma

Kirjavainen PV, Täubel M, Karvonen AM, Sulyok M, Tiittanen P, Krska R, Hyvärinen A, Pekkanen J. 2015. Indoor air. first published online: 3 JUN 2015: -

Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms

Lappi Jenni, Mykkänen Hannu, Bach Knudsen Knud Erik, Kirjavainen Pirkka, Katina Kati, Pihlajamäki Jussi, Poutanen Kaisa, Kolehmainen Marjukka. 2014. Nutrition journal. 13: -

Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet

Mykkänen Otto T, Huotari Anne, Herzig Karl-Heinz, Dunlop Thomas W, Mykkänen Hannu, Kirjavainen Pirkka V. 2014. PLoS ONE. 9: e114790

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

Kolehmainen M, Mykkänen O, Kirjavainen PV, Leppänen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimiä R, Pulkkinen L, Mykkänen H, Gylling H, Poutanen K, Törrönen R. 2012. Molecular nutrition and food research. 56: 1501-1510

Ravinto ja suolistomikrobisto

Kirjavainen P, von Wright A, Mykkänen H. Teoksessa: Aro A, Mutanen M, Uusitupa M(toim.) , 2012. Ravitsemustiede. s. 183-195. Duodecim

Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Koyama T, Kirjavainen PV, Fisher C, Anukam CF, Summers K, Hekmat S & Reid G. 2010. Canadian journal of microbiology. 56: 730-438

Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections

Kirjavainen PV, Pautler S, Baroja ML, Anukam K, Crowley K, Carter K, Reid G, Kirjavainen PV. 2009. Clinical and vaccine immunology. 16: 29-36

Effect of bacterial vaginosis, Lactobacillus and premarin estrogen replacement therapy on vaginal gene expression changes

Dahn A, Saunders S, Hammond J-A, Carter D, Kirjavainen P, Anukam K, Reid G, Kirjavainen Pirkka. 2008. Microbes and infection. 10: 620-627

Expression of anti-microbial defence factors in vaginal mucosa following exposure to Lactobacillus rhamnosus GR-1

Kirjavainen PV, Laine RM, Carter DE, Hammond J-O, Reid G. 2008. International journal of probiotics & prebiotics. 3: 99-106

Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients

Baroja ML, Kirjavainen PV, Hekmat S, Reid G. 2007. Clinical and experimental immunology. 149: 470-479

Postnatal effects of obstetrical epidural anesthesia on allergic sensitization

Kirjavainen PV, Kalliomäki M, Salminen SJ, Isolauri E, Kirjavainen PV. 2007. Allergy. 62: 87-88

Tarkenna hakuasi

Tutkimusryhmät

Continuous rather than solely early farm exposure protect from hay fever development

Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts

Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study

Kotipölystä sekvensoitujen sienten yhteys astmaan - tuloksia suomalaisesta syntymäkohorttitutkimuksesta

Associations between residential greenness, indoor microbiota and risk of developing allergic rhinitis

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding

Determinants of bacterial and fungal microbiota in Finnish home dust: Impact of environmental biodiversity, pets, and occupants

Early‐life residential exposure to moisture damage is associated with persistent wheezing in a Finnish birth cohort

Environmental microbiota transfer into urban homes

Farm home-like indoor microbiota protects form asthma in urban homes

Fungal diversity and quantity in house dust and wheezing phenotypes

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention

Role of house dust microbiota in health benefits of dog keeping

The Effects of Single Strains and Mixtures of Probiotic Bacteria on Immune Profile in Liver, Spleen, and Peripheral Blood

The Microbiome as a Gateway to Prevention of Allergic Disease Development

Associations between dog keeping and indoor dust microbiota

Early age exposure to moisture and mould is related to FeNO at the age of 6 years

Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts

Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Reply

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Early life home microbiome and hyperactivity/inattention in school-age children

Farm-like indoor microbiota in non-farm homes protects children from asthma development

Indoor Bacterial Microbiota and the Development of Asthma by 10.5 years of age

Maatalomainen kodin mikrobisto voi suojata astmalta kaupungissakin

Parents know it best: Prediction of asthma and lung function by parental perception of early wheezing episodes

Crawling-induced floor dust resuspension affects the microbiota of the infant breathing zone

Early age exposure to moisture damage and systemic inflammation at the age of 6 years

High levels of Butyrate and Propionate in early life are associated with protection against atopy

Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

Microbial secondary metabolites in homes in association with moisture damage and asthma

Postprandial glucose metabolism and SCFA after consuming wholegrain rye bread and wheat bread enriched with bioprocessed rye bran in individuals with mild gastrointestinal symptoms

Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet

Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome

Ravinto ja suolistomikrobisto

Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis

Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections

Effect of bacterial vaginosis, Lactobacillus and premarin estrogen replacement therapy on vaginal gene expression changes

Expression of anti-microbial defence factors in vaginal mucosa following exposure to Lactobacillus rhamnosus GR-1

Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients

Postnatal effects of obstetrical epidural anesthesia on allergic sensitization