Seppo Auriola
Professori
Analyyttisen kemian opetus. Tutkijoiden ohjaus ja Ttutkimus: lääkeanalytiikka, massaspektrometria, metabolomiikka
Terveystieteiden tiedekunta, Farmasian laitos
seppo.auriola@uef.fi | 040 355 2469
0403552469
040 3552469
040 355 2469
+358 40 355 2469
+35840 355 2469
040 3552 469
+358 40 3552 469
+35840 3552 469
+358 40 3552469
+35840 3552469
+358403552469
040 3552469
040 355 2469
+358 40 355 2469
+35840 355 2469
040 3552 469
+358 40 3552 469
+35840 3552 469
+358 40 3552469
+35840 3552469
+358403552469
Tutkimusryhmät
-
Farmasian analytiikkayksikkö 27.02.2020 - 01.01.2025 -
Mikromuovitutkimus 01.01.2018 - -
Silmälääketutkimusryhmä 01.01.2010 -
Projektit
Julkaisut
200 kappaletta-
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity
Šadibolová, Michaela; Juvonen, Risto O.; Auriola, Seppo; Boušová, Iva. Archives of toxicology 96: 793-808. 2022 -
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues
Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. Pharmaceutics 13 5: 658. 2021 -
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. Metabolomics 17 2: 20. 2021 -
The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality
Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi. Pharmaceutical research 38 10: 1663-1675. 2021 -
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder
Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo. Alcoholism-clinical and experimental research 45 11: 2207-2216. 2021 -
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. Addiction biology 26 6: e13035. 2021 -
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)
Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. International journal of molecular sciences 22 14: 7727. 2021 -
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. Journal of pharmaceutical sciences 110 12: 3953-3962. 2021 -
Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial
Raittinen, Paavo V.H.; Syvälä, Heimo; Tammela, Teuvo L.J.; Häkkinen, Merja R.; Ilmonen, Pauliina; Auriola, Seppo; Murtola, Teemu J.. EBioMedicine 68: 103432. 2021 -
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche
Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Häkkinen, Merja; Auriola, Seppo; Morin-Papunen, Laure; Liimatta, Jani. Journal of clinical endocrinology and metabolism 106 9: e3335-e3345. 2021 -
Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach
Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. Nutrition metabolism and cardiovascular diseases 31 4: 1156-1165. 2021 -
Pharmacological inhibition of 17ß-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model
Xanthoulea, Sofia; Konings, Gonda F.J.; Saarinen, Niina; Delvoux, Bert; Kooreman, Loes F.S.; Koskimies, Pasi; Häkkinen, Merja R.; Auriola, Seppo; D'Avanzo, Elisabetta; Walid, Youssef; Verhaegen, Frank; Lieuwes, Natasja G.; Caiment, Florian; Kruitwagen, Roy; ENITEC; Romano, Andrea. Cancer letters 508 28: 18-29. 2021 -
Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery
Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. Journal of controlled release 327: 584-594. 2020 -
Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing
Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. Molecular pharmaceutics 17 6: 1945-1953. 2020 -
Side-stream products of malting: a neglected source of phytochemicals
Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. npj science of food 4 1: 21. 2020 -
Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up
Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. Alcoholism-clinical and experimental research 44 12: 2457-2467. 2020 -
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. European journal of nutrition 2021; 60: 193-201. 2020 -
L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells
Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. Acs chemical neuroscience 11 24: 4301-4315. 2020 -
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms
Noerman, S; Klåvus, A; Järvelä-Reijonen, E; Karhunen, L; Auriola, S; Korpela, R; Lappalainen, R; Kujala, UM; Puttonen, S; Kolehmainen, M; Hanhineva, K. Scientific reports 10 1: 2143. 2020 -
Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles
Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia. Cancers 12 11: 3292. 2020 -
L-Type amino acid transporter 1 as a target for drug delivery
Puris, Elena; Gynther, Mikko; Auriola, Seppo; Huttunen, Kristiina. Pharmaceutical research 37 5: 88. 2020 -
Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer
Raittinen, Paavo; Niemistö, Kati; Pennanen, Erika; Syvälä, Heimo; Auriola, Seppo; Riikonen, Jarno; Lehtimäki, Terho; Ilmonen, Pauliina; Murtola, Teemu. Scientific reports 10: 12016. 2020 -
Metabolome of canine and human saliva: a non-targeted metabolomics study
Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati. Metabolomics 16 9: 90. 2020 -
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. Molecular pharmaceutics 16 9: 3968-3976. 2019 -
L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. Scientific reports 9: 12860. 2019 -
Metabolism of Scoparone in Experimental Animals and Humans
Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. Planta medica 85 06: 453-464. 2019 -
Access and concentrations of atorvastatin in the prostate in men with prostate cancer
Knuuttila, Emma; Riikonen, Jarno; Syvälä, Heimo; Auriola, Seppo; Murtola, Teemu J. Prostate 79 12: 1427-1434. 2019 -
Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation
Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. Microbiome 7: 103. 2019 -
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. Hormone research in paediatrics 91: 329-335. 2019 -
Metabolic signature of extracellular vesicles depends on the cell culture conditions
Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M. Journal of extracellular vesicles 8 1: 1596669. 2019 -
Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180
Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. Toxicology and applied pharmacology 370: 56-64. 2019 -
L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
Puris, E; Gynther, M; Huttunen, J; Auriola, S; Huttunen, KM. European journal of pharmaceutical sciences 129: 99-109. 2019 -
Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C M; Auriola, Seppo; Harnmarlund-Udenaes, Margareta; Huttunen, Kristiina M; Loryan, Irena. Molecular pharmaceutics 16 7: 3261-3274. 2019 -
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. American journal of clinical nutrition 110 5: 1108-1118. 2019 -
High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice
Airaksinen, Kaisa; Jokkala, Jenna; Ahonen, Ilmari; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Tiihonen, Kirsti. Molecular Nutrition & Food Research 62 23: 1800455. 2018 -
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. PHARMACEUTICAL RESEARCH 2019; 36: 17. 2018 -
Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue
Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2019; 164: 642-652. 2018 -
Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue
Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 152: 165-172. 2018 -
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. Scientific reports 8: 14616. 2018 -
Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure
Konings, GF; Saarinen, N; Delvoux, B; Kooreman, L; Koskimies, P; Krakstad, C; Fasmer, KE; Haldorsen, IS; Zaffagnini, A; Häkkinen, MR; Auriola, S; Dubois, L; Lieuwes, N; Verhaegen, F; Schyns, LE; Kruitwagen, RF; Xanthoulea, S; Romano, A. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 9: 2547. 2018 -
Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake
Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. INTERNATIONAL JOURNAL OF PHARMACEUTICS 544 1: 91-99. 2018 -
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. American journal of clinical nutrition 108 5: 971-979. 2018 -
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. Scientific reports 8: 13036. 2018 -
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 223: 79-84. 2018 -
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. Brain, behavior, and immunity 73: 670-681. 2018 -
Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase
Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. Bioorganic chemistry 80: 655-667. 2018 -
Transplacental Transfer and Metabolism of Diuron in Human Placenta
Mohammed, Ali Mustafa; Karttunen, Vesa; Huuskonen, Pasi; Huovinen, Marjo; Auriola, Seppo; Vähäkangas, Kirsi. TOXICOLOGY LETTERS 295: 307-313. 2018 -
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. DIABETOLOGIA 61 4: 849-861. 2018 -
Blood steroids are associated with prognosis and fat distribution in endometrial cancer
Tangen, IL; Fasmer, KE; Konings, GF; Jochems, A; Delvoux, B; Xanthoulea, S; Stokowy, T; Strand, E; Berg, HF; Auriola, S; Trovik, J; Häkkinen, MR; Haldorsen, IS. GYNECOLOGIC ONCOLOGY 2019; 152 1: 46-52. 2018 -
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. Nutrition and diabetes 8: 35. 2018 -
Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. JOURNAL OF CONTROLLED RELEASE 251: 37-48. 2017 -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. Scientific Reports 7: 46337. 2017 -
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals
Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. Planta Medica 2018; 84 5: 320-328. 2017 -
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist
Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. JOURNAL OF MEDICINAL CHEMISTRY 60 23: 9885-9904. 2017 -
Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. AMERICAN JOURNAL OF PATHOLOGY 2018; 188 1: 216-228. 2017 -
Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model
Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. JOURNAL OF PHARMACEUTICAL SCIENCES 106 9: 2463-2471. 2017 -
Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig
Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. Molecular Pharmaceutics 14 11: 3729-3738. 2017 -
Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. ALCOHOL 52: 63-70. 2016 -
Butyrophilin 3A/CD277-Dependent Activation of Human gamma delta T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations
Nerdal Patrik T, Peters Christian, Oberg Hans-Heinrich, Zlatev Hristo, Lettau Marcus, Quabius Elgar S, Sousa Sofia, Gonnermann Daniel, Auriola Seppo, Olive Daniel, Määttä Jorma, Janssen Ottmar, Kabelitz Dieter. JOURNAL OF IMMUNOLOGY (BALTIMORE) 197: 3059-3068. 2016 -
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling
Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. Molecular Pharmaceutics 13 4: 1358-1365. 2016 -
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells
Zlatev Hristo P, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma A. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 86: 58-66. 2016 -
Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling
Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. Molecular Nutrition & Food Research [epub ahead of print 10 SEP 2015]: -. 2015 -
Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1
Huuskonen Pasi, Auriola Seppo, Pasanen Markku. PLACENTA (LONDON) 36 9: 1052-1055. 2015 -
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. XENOBIOTICA (LONDON) 2016; 46 1: 14-24. 2015 -
Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites
Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. Toxicology Reports 2: 1024-1032. 2015 -
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. PLOS ONE [ONLINE] 10 4: e0124379. 2015 -
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations
Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. TOXICOLOGY LETTERS 239 2: 108-114. 2015 -
Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells
Sousa Sofia, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 15 4: 1-11. 2015 -
Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells
Ebert Regina, Meissner-Weigl Jutta, Zeck Sabine, Määttä Jorma, Auriola Seppo, Coimbra de Sousa Sofia, Mentrup Birgit, Graser Stephanie, Rachner Tilman D, Hofbauer Lorenz C, Jakob Franz. Molecular Cancer 13: 265. 2014 -
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1950-1957. 2014 -
Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions
Huhtinen Kaisa, Saloniemi-Heinonen Taija, Keski-Rahkonen Pekka, Desai Reena, Laajala Daniel, Ståhle Mia, Häkkinen Merja R, Awosanya Michael, Suvitie Pia, Kujari Harry, Aittokallio Tero, Handelsman David J, Auriola Seppo, Perheentupa Antti, Poutanen Matti. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 99: E2188-E2197. 2014 -
Castration Induces Up-Regulation of Intratumoral Androgen Biosynthesis and Androgen Receptor Expression in an Orthotopic VCaP Human Prostate Cancer Xenograft Model
Knuuttila Matias, Yatkin Emrah, Kallio Jenny, Savolainen Saija, Laajala Teemu D, Aittokallio Tero, Oksala Riikka, Häkkinen Merja, Keski-Rahkonen Pekka, Auriola Seppo, Poutanen Matti, Mäkelä Sari. AMERICAN JOURNAL OF PATHOLOGY 184: 2163-2173. 2014 -
Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity
Landreh Luise, Spinnler Katrin, Schubert Kerstin, Häkkinen Merja R, Auriola Seppo, Poutanen Matti, Söder Olle, Svechnikov Konstantin, Mayerhofer Artur. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 99: E1227-E1235. 2014 -
Bisphosphonate research
Määttä Jorma, Mönkkönen Jukka, Auriola Seppo, Sousa Sofia, Zlatev Hristo, Arkko Satu. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 199. 2014 -
Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools
Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 2015; 22: 538-550. 2014 -
Quantitative Evaluation of Intracellular Distribution and Human Placental Transfer of Doxorubicin and its Liposomal Formulations
Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Koivisto Heta, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. -, Conference Book: The Globalization of Pharmaceutics Education Network. -. 2014 -
Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. FOOD CHEMISTRY 165: 499-505. 2014 -
Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. PHYTOCHEMICAL ANALYSIS 25: 220-228. 2014 -
Conjugation of peptides to antisense interleukin-6 via click chemistry
Wang Chang-Fang, Auriola Seppo, Hirvonen Jouni, Santos Hélder A. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 21: 1247-1254. 2014 -
Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS
Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 941: 81-89. 2013 -
LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization
Keski-Rahkonen Pekka, Huhtinen Kaisa, Desai Reena, Harwood D. Tim, Handelsman David J, Poutanen Matti, Auriola Seppo. JOURNAL OF MASS SPECTROMETRY 48: 1050-1058. 2013 -
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. Molecular Nutrition & Food Research 57: 1959-1968. 2013 -
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013 -
Peptides conjugated to antisense interleukin-6 by click chemistry
Wang Chang-Fang, Auriola Seppo, Hirvonen Jouni, Santos Hélder A. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 2014:21 10: 1247-1254. 2013 -
Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells
Huuskonen Pasi, Storvik Markus, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku / 48th Congress of the European Societies of Toxicology (EUROTOX), Stockholm, Sweden, 17th-20th June 2012. 2012. 2012 -
Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids
Ahonen Linda, Keski-Rahkonen Pekka, Saarelainen Taija, Paviala Jenni, Ketola Raimo A, Auriola Seppo, Poutanen Matti, Kostiainen Risto. ANALYTICA CHIMICA ACTA (AMSTERDAM) 721: 115-121. 2012 -
Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS
Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. AMINO ACIDS 42: 451-460. 2012 -
Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine
Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012 -
Acute effects of ethanol on transplacental transfer
Karttunen Vesa, Veid Jenni, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. Teoksessa: (toim.), 48th Congress of the European Societies of Toxicology (EUROTOX), Stockholm, Sweden, 17th-20th June 2012. ss. 211S:S186. 2012 -
Intratumor Androgen Biosynthesis in VCaP Xenografts - A model for Castration-Resistant Prostate Cancer
Knuuttila Matias, Yatkin E, Kallio J, Savolainen S, Auriola Seppo, Poutanen M, Mäkelä S. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:318. 2012 -
Transplacental transfer of melamine
Partanen Heidi, Vähäkangas Kirsi, Woo Chit SJ, Auriola Seppo, Veid Jenni, Chen Y, Myllynen Päivi, El Nezami Hani. PLACENTA (LONDON) 33: 60-66. 2012 -
Human Placental Perfusions of Anticancer Drug Doxorubicin and Liposomes Encapsulated with Doxorubicin
Repo Jenni, Soininen Suvi K, Meftah Azin, Auriola Seppo, Ruponen Marika, Vähäkangas Kirsi. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012 -
2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites
Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. TOXICOLOGY LETTERS 207: 34-41. 2011 -
Fast and sensitive liquid chromatography-mass spectometry assay for seven androgenic and progestagenic steroids in human serum
Keski-Rahkonen Pekka, Huhtinen Kaisa, Poutanen Matti, Auriola Seppo. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 127: 396-404. 2011 -
d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. TOXICOLOGY IN VITRO 25: 411 - 425. 2011 -
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry
Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 879: 677 - 694. 2011 -
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Räikkönen Johanna, Taskinen Markku, Dunford James E, Mönkkönen Hannu, Auriola Seppo, Mönkkönen Jukka. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407: 663-667. 2011 -
Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics
Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. DRUG METABOLISM AND DISPOSITION 39 3: 412 - 418. 2011 -
Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells
Storvik Markus, Huuskonen Pasi, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku. Toxicology letters 202 3: 161 - 167. 2011 -
Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices - Enhanced stability and release
Valo Hanna, Kovalainen Miia, Laaksonen Päivi, Häkkinen Merja, Auriola Seppo, Peltonen Leena, Linder Markus, Järvinen Kristiina, Hirvonen Jouni, Laaksonen Timo. JOURNAL OF CONTROLLED RELEASE 156: 390-397. 2011 -
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion
Veid Jenni, Karttunen Vesa, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. TOXICOLOGY LETTERS 205: 257-264. 2011 -
Genetic and environmental influence on maize kernel proteome
Anttonen MJ, Lehesranta S, Auriola S, Röhlig RM, Engel K-H & Kärenlampi SO. JOURNAL OF PROTEOME RESEARCH 9 12: 6160-6168. 2010 -
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. AMINO ACIDS 38: 369-381. 2010 -
Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations
Koskela Ali, Anttonen Mikko, Soininen Tuula, Auriola Seppo, Julkunen-Tiitto Riitta, Karjalainen Reijo. Teoksessa: (toim.), XXV International conference on polyphenols: polyphenols communications 2010 volume 2. ss. 552-553. 2010 -
Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).
Koskela, A., Anttonen, M., Soininen, T., Saviranta, N., Auriola, S., Julkunen-Tiitto, R. and Karjalainen, R.. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58 23: 12289-12295. 2010 -
Assessment of bisphosphonate activity in vitro
Mitrofan LM, Auriola S, Mönkkönen H & Mönkkönen J. CURRENT PHARMACEUTICAL DESIGN 16 27: 2970-2980. 2010 -
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells
Räikkönen J, Mönkkönen H, Auriola S & Mönkkönen J. BIOCHEMICAL PHARMACOLOGY 79: 777 - 783. 2010 -
Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells
Stenman SM, Lindfors K, Venäläinen JI, Hautala A, Männistö PT, Garcia-Horsman JA, Kaukovirta-Norja A, Auriola S, Mauriala T, Mäki M et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 161: 242-249. 2010 -
Proteomics of Thlaspi caerulescens accessions and an inter-accession cross segregating for zinc accumulation
Tuomainen M, Tervahauta A, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Häyrinen J, Auriola S, Anttonen M & Kärenlampi S. JOURNAL OF EXPERIMENTAL BOTANY 61 4: 1075-1087. 2010 -
Proteomics of Thlaspi caerulescens accessions and inter-accession cross segregating for zinc accumulation
Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen K, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. , Reports and studies in forestry and natural sciences: IX Finnish SYmposium on Plant Science, May 17-19, Joensuu, Finland. 80. 2010 -
Proteomic study of zinc accumulation and tolerance in metal hyperaccumulator plant Thlaspi caerulescens
Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. , 4th Annual FinnProt Symposium "Quantitative Proteomics" April 14th-16th 2010, Abstract book. 11. 2010 -
Synthesis of novel deuterium labelled derivates of N-alkylated polyamines
Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. TETRAHEDRON 65 2: 547-562. 2009 -
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry
Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877: 2967-2975. 2009 -
Atmospheric pressure thermospray ionization using a heated microchip nebulizer
Keski-Rahkonen P, Haapala M, Saarela V, Franssila S, Kotiaho T, Kostiainen R, Auriola S. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 23: 3313-3322. 2009 -
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
Laine JE, Auriola S, Pasanen M, Juvonen RO. XENOBIOTICA (LONDON) 39 1: 11-21. 2009 -
Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate
Mannila J, Järvinen K, Holappa J, Matilainen L, Auriola S, Jarho P. INTERNATIONAL JOURNAL OF PHARMACEUTICS 381: 19-24. 2009 -
The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder
Matilainen L, Maunu SL, Pajander J, Auriola S, Jääskeläinen I, Lambertsen Larsen K, Järvinen T, Jarho P. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 36: 412-420. 2009 -
Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension
Qu C-J, Pöytäkangas T, Jauhiainen M, Auriola S, Lammi MJ. CELL AND TISSUE RESEARCH 337: 103-111. 2009 -
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J. BRITISH JOURNAL OF PHARMACOLOGY 157: 427-435. 2009 -
Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease
Stenman SM, Venäläinen JI, Lindfors K, Auriola S, Mauriala T, Kaukovirta-Norja A, Jantunen A, Laurila K, Qiao S-W, Sollid LM, Männistö PT, Kaukinen K, Mäki M. Annals of Medicine 41: 390-400. 2009 -
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 48: 414-421. 2008 -
Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines
Jokela TA, Jauhiainen M, Auriola S, Kauhanen M, Tiihonen R, Tammi MI, Tammi RH. JOURNAL OF BIOLOGICAL CHEMISTRY 283 12: 7666-7673. 2008 -
Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing
Koponen JM, Happonen AM, Auriola S, Kontkanen H, Buchert J, Poutanen KS, Törrönen R, Koponen JM, Happonen AM, Poutanen KS, Törrönen R. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56: 3136-3144. 2008 -
Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes
Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. CHEMISTRY & BIODIVERSITY 5: 2431-2441. 2008 -
The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes
Matilainen L, Lambertsen Larsen K, Wimmer R, Keski-Rahkonen P, Auriola S, Järvinen T, Jarho P. JOURNAL OF PHARMACEUTICAL SCIENCES 97 7: 2720-2729. 2008 -
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth
Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J. ANTI-CANCER DRUGS 19: 391-399. 2008 -
Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats
Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH. PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 456: 369-377. 2008 -
High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone
Pulkkinen M, Palmgrén JJ, Auriola S, Malin M, Seppälä J, Järvinen K. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 22: 121-129. 2008 -
Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo
Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. XENOBIOTICA (LONDON) 38 1: 34-47. 2008 -
Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity
Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008 -
Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease
Garcia-Horsman JA, Venäläinen JI, Lohi O, Auriola IS, Korponay-Szabo IR, Kaukinen K, Mäki M, Männistö PT. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 42: 562-571. 2007 -
Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 45: 625-634. 2007 -
Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry
Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 21 18: 2933-2943. 2007 -
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry
Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 43: 606-612. 2007 -
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007 -
Zoledronic acid-induced IPP/ApppI production in vivo
Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. LIFE SCIENCES 81: 1066-1070. 2007 -
Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes
Qu C-J, Jauhianen M, Auriola S , Helminen Heikki J, Lammi MJ. OSTEOARTHRITIS AND CARTILAGE 15: 773-779. 2007 -
In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A
Matilainen L, Järvinen K, Toropainen T, Näsi E, Auriola S, Järvinen T, Jarho P. INTERNATIONAL JOURNAL OF PHARMACEUTICS 318: 41-48. 2006 -
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. BRITISH JOURNAL OF PHARMACOLOGY 147: 437-445. 2006 -
Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
Palmgrén JJ, Mönkkönen J, Korjamo T, Hassinen A, Auriola S. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 64: 369-378. 2006 -
Multivariate analysis of protein profiles of metal hyperaccumulator Thlaspi caerulescens accessions
Tuomainen MH, Nunan N, Lehesranta SJ, Tervahauta AI, Hassinen VH, Schat H, Koistinen KM, Auriola S, McNicol J, Kärenlampi SO. PROTEOMICS 6: 3696-3706. 2006 -
Analysis of bean (Phaseolus vulgaris L.) proteins affected by copper stress
Cuypers A, Koistinen KM, Kokko H, Kärenlampi S, Auriola S, Vangronsveld J. JOURNAL OF PLANT PHYSIOLOGY 162: 383-392. 2005 -
Proteomic analysis of glial fibrillary acidic protein in Alzheimer¿s disease and aging brain
Korolainen MA, Auriola S, Nyman TA, Alafuzoff I, Pirttilä T, Korolainen MA, Pirttilä T. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 858-870. 2005 -
Comparison of tuber proteomes of potato varieties, landraces, and genetically modified lines
Lehesranta SJ, Davies HV, Shepherd LVT, Nunan N, McNicol JW, Auriola S, Koistinen KM, Suomalainen S, Kokko HI, Kärenlampi SO. PLANT PHYSIOLOGY 138: 1690-1699. 2005 -
Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
Palmgrén JJ, Töyräs A, Mauriala T, Mönkkönen J, Auriola S. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 821: 144-152. 2005 -
Isolation and characterization of yuremamine, a new phytoindole
Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. PLANTA MEDICA 71: 1053-1057. 2005 -
The microglia-activating potential of thrombin
Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. JOURNAL OF BIOLOGICAL CHEMISTRY 279 50: 51880-51887. 2004 -
Effects of triaryl phosphates on mouse and human nuclear receptors
Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. BIOCHEMICAL PHARMACOLOGY 67: 97-106. 2004 -
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. NEUROSCIENCE LETTERS 367 2: 235-240. 2004 -
Partial amino acid sequence of a cellullase-like component with IgE-binding properties from stachybotrys chartarum
Kärkkäinen M, Raunio P, Rautiainen J, Auriola S, Hinke K, Pasanen A-L. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 133: 136-144. 2004 -
HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis
Mauriala T, Auriola S, Azhayev A, Kayushin A, Korosteleva M, Miroshnikov A. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 34: 199-206. 2004 -
Determination of long-chain fatty acid acyl-coenzyme A compounds using liquid chromatography-electrospray ionization tandem mass spectrometry
Mauriala T, Herzig KH, Heinonen M, Idziak J, Auriola S. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 808 2: 263-268. 2004 -
Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC
Palmgrén J, Mönkkönen J, Jukkola E, Niva S, Auriola S. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 57: 319-328. 2004 -
Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004 -
Selective circular oligonucleotide probes improve detection of point mutations in DNA
Tennilä T, Ketomäki K, Penttinen P, Tengvall U, Azhayeva E, Auriola S, Lönnberg H, Azhayev A. CHEMISTRY & BIODIVERSITY 1 4: 609-625. 2004 -
Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies
Kostiainen R, Kotiaho T, Kuuranne T, Auriola S. JOURNAL OF MASS SPECTROMETRY 38: 357-372. 2003 -
Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects
Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: 23-29. 2003 -
Characterization of antisense oligonucleotide-peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography-mass spectrometry
Tengvall U, Auriola S, Antopolsky M, Azhayev A, Biegelman L. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 32: 581-590. 2003 -
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 20: 99-106. 2003 -
Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium
El-Nezami HS, Chrevatidis A, Auriola S, Salminen S, Mykkänen H. FOOD ADDITIVES AND CONTAMINANTS 19: 680-686. 2002 -
Birch PR-10c is induced by factors causing oxidative stress but appears not to confer tolerance to these agents
Koistinen KM, Hassinen VH, Gynther PAM, Lehesranta SJ, Keinänen SI, Kokko HI, Oksanen EJ, Tervahauta AI, Auriola S, Kärenlampi SO. NEW PHYTOLOGIST 155: 381-391. 2002 -
Stress-related RNase PR-10c is post-translationally modified by glutathione in birch
Koistinen KM, Kokko HI, Hassinen VH, Tervahauta AI, Auriola S, Kärenlampi SO. PLANT, CELL AND ENVIRONMENT 25: 707-715. 2002 -
Isolation and identification of Aspergillus fumigatus mycotoxins on growth medium and some building materials
Nieminen SM, Kärki R, Auriola S, Toivola M, Laatsch H, Laatikainen R, Hyvärinen A, Von Wright A. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 68 10: 4871-4875. 2002 -
High-performance liquid chromatography-mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin determination of gamma-carboxyglutamic acid residues
Niiranen H, Budnik BA, Zubarev RA, Auriola S, Lapinjoki S. JOURNAL OF CHROMATOGRAPHY A 962: 95-103. 2002 -
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
Niittynen M, Tuomisto JT, Auriola S, Pohjanvirta R, Syrjälä P, Simanainen U, Viluksela M, Tuomisto J. TOXICOLOGICAL SCIENCES 71: 112-123. 2002 -
Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols
Palmgrén JJ, Toropainen E, Auriola S, Urtti A. JOURNAL OF CHROMATOGRAPHY A 976: 165-170. 2002 -
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro
Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 772: 81-87. 2002 -
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate
Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. ARTHRITIS AND RHEUMATISM 44 9: 2201-2210. 2001 -
The cellular uptake and metabolism of clodronate in RAW 264 macrophages
Mönkkönen H, Rogers MJ, Makkonen N, Niva S, Auriola S, Mönkkönen J. PHARMACEUTICAL RESEARCH 18 11: 1550-1555. 2001 -
Two new variants of the lipocalin allergen Bos d 2
Rautiainen J, Auriola S, Konttinen A, Virtanen T, Rytkönen-Nissinen M, Zeiler T, Mäntyjärvi R. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 763: 91-98. 2001 -
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells
Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. JOURNAL OF CELLULAR BIOCHEMISTRY 79: 610-619. 2000 -
Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye
Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 9: 265-270. 2000 -
Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry
Mönkkönen H, Moilanen P, Mönkkönen J, Frith JC, Rogers MJ, Auriola S. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 738: 395-403. 2000 -
Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes
Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. ARCHIVES OF TOXICOLOGY 74: 511-520. 2000 -
Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties
Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. BIOCONJUGATE CHEMISTRY 10 4: 598-606. 1999 -
Analysis of adenine nucleotide containing metabolite of clodronate using ion pair HPLC-ESI-MS
Auriola S, Monkkonen H, Frith J, Rogers M, Monkkonen J. , The 47th ASMS Conference on Mass Spectrometry And Allied Topics. Proceedings. [CD-ROM]. 1999 -
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
Benford HL, Frith JC, Auriola S, Mönkkönen J, Rogers MJ. MOLECULAR PHARMACOLOGY 56: 131-140. 1999 -
Mass spectrometric (HPLC/ESI-MS/MS) quantification of pyrimido[1,2-a]purin-10(3H)-one, a guanine adduct formed by reaction of malondialdehyde with DNA
Hakala K, Auriola S, Koivisto A, Lönnberg H. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 21: 1053-1061. 1999 -
Effects of bisphosphonates on the inflammatory processes of activated macrophages
Mönkkönen J, Makkonen N, Rogers MJ, Frith JC, Auriola S. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS 144-146: 321-324. 1999 -
Molecular mechanisms of action of bisphosphonates
Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RGG. BONE 24 5: 73S-79S. 1999 -
Antibioottiset peptidit
Toroskainen C, Auriola S. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 15 1: 12-22. 1999 -
High-performance liquid chromatography-mass spectrometry of an osteocalcin derivative
Vähätalo H, Auriola S, Lapinjoki S. JOURNAL OF CHROMATOGRAPHY A 846: 49-57. 1999 -
Enhancement of sample loadings for the analysis of oligosaccharides isolated from pseudomonas aeruginosa using transient isotachophoresis and capillary zone electrophoresis - electrospray - mass spectrometry
Auriola S, Thibault P, Sadovskaya I, Altman E. ELECTROPHORESIS 19: 2665-2676. 1998 -
New building blocks for the preparation of branched oligonucleotides
Azhayev A, Auriola S, Hovinen J. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS 17: 1527-1537. 1998 -
High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries
Häkkinen S, Auriola S. JOURNAL OF CHROMATOGRAPHY A 829: 91-100. 1998 -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro
Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 709: 1-10. 1998 -
Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family
Rautiainen J, Auriola S, Rouvinen J, Kauppinen J, Zeiler T, Novikov D, Virtanen T, Mäntyjärvi RA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 247: 746-750. 1998 -
PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula
Utriainen M, Kokko H, Auriola S, Sarrazin O, Kärenlampi S. PLANT, CELL AND ENVIRONMENT 21: 821-828. 1998 -
Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry
Auriola S, Frith J, Rogers MJ, Koivuniemi A, Mönkkönen J. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 704: 187-195. 1997 -
Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry
Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. , The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. 651. 1997 -
Inhibitory properties of double helix forming circular oligonucleotides
Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. NUCLEIC ACIDS RESEARCH 25 24: 4954-4961. 1997 -
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 38 3: 627-634. 1997 -
Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach
Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. JOURNAL OF CONTROLLED RELEASE 49: 97-104. 1997 -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection
Ranta V-P, Urtti A, Auriola S. JOURNAL OF CHROMATOGRAPHY A 766: 85-97. 1997 -
Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns
Auriola S, Jääskeläinen I, Regina M, Urtti A. ANALYTICAL CHEMISTRY 68 22: 3907-3911. 1996 -
Determination of urinary 2-mercaptobenzothiazole (2-MBT), the main metabolite of 2-(thiocyanomethylthio)benzothiazole (TCMTB) in humans and rats
Manninen A, Auriola S, Vartiainen M, Liesivuori J, Turunen T, Pasanen M. ARCHIVES OF TOXICOLOGY 70: 579-584. 1996 -
CE-MS and MS-MS analyses of lipopolysaccharides from p.aeruginosa
Auriola S, Thibault P, Sadovskaya I, Masoud H, Altman E, Richards JC. Teoksessa: (toim.), Proceedings the 43rd ASMS Conference on Mass Spectrometry and Allied Topics. ss. 977. 1995 -
Glucose metabolism in the developing cerebral cortex as detected by 1H {13C} nuclear magnetic resonance spectroscopy ex vivo
Pirttilä T-RM, Auriola SOK, Kauppinen R. JOURNAL OF NEUROCHEMISTRY 64: 417-423. 1995 -
Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases
Gibson BW, Medzihradszky D, Hines WM, Auriola S, Kenyon GL. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 5: 443-451. 1994 -
Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r
Kauppinen RA, Pirttilä T-RM, Auriola SOK, Williams SR. BIOCHEMICAL JOURNAL 298: 121-127. 1994