SEPPO AURIOLA

Yhteystiedot

TUTKIMUSRYHMÄT - UEF

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  Farmasian analytiikkayksikkö
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  Mikromuovitutkimus
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  Silmälääketutkimusryhmä
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  Soveltava kemia

Julkaisut

• Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues Pharmaceutics 13 5: 658. 2021
• Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use Addiction biology [Published online: 21 March 2021]: e13035. 2021
• Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP) International journal of molecular sciences 22 17: 7727. 2021
• Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model Journal of pharmaceutical sciences [In Press, Journal Pre-proof 14.8.]: 30 pages. 2021
• Raittinen, Paavo V.H.; Syvälä, Heimo; Tammela, Teuvo L.J.; Häkkinen, Merja R.; Ilmonen, Pauliina; Auriola, Seppo; Murtola, Teemu J.. 2021. Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial EBioMedicine 68: 103432. 2021
• Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Häkkinen, Merja; Auriola, Seppo; Morin-Papunen, Laure; Liimatta, Jani. 2021. PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche Journal of clinical endocrinology and metabolism 106 9: e3335-e3345. 2021
• Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. 2021. Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach Nutrition metabolism and cardiovascular diseases 31 4: 1156-1165. 2021
• Xanthoulea, Sofia; Konings, Gonda F.J.; Saarinen, Niina; Delvoux, Bert; Kooreman, Loes F.S.; Koskimies, Pasi; Häkkinen, Merja R.; Auriola, Seppo; D'Avanzo, Elisabetta; Walid, Youssef; Verhaegen, Frank; Lieuwes, Natasja G.; Caiment, Florian; Kruitwagen, Roy; ENITEC; Romano, Andrea. 2021. Pharmacological inhibition of 17ß-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model Cancer letters 508 28: 18-29. 2021
• Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies Metabolomics 17 2: 1-12. 2021
• Noerman, S; Klåvus, A; Järvelä-Reijonen, E; Karhunen, L; Auriola, S; Korpela, R; Lappalainen, R; Kujala, UM; Puttonen, S; Kolehmainen, M; Hanhineva, K. 2020. Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms Scientific reports 10 1: 2143. 2020
• Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati. 2020. Metabolome of canine and human saliva: a non-targeted metabolomics study Metabolomics 16 9: 90. 2020
• Raittinen, Paavo; Niemistö, Kati; Pennanen, Erika; Syvälä, Heimo; Auriola, Seppo; Riikonen, Jarno; Lehtimäki, Terho; Ilmonen, Pauliina; Murtola, Teemu. 2020. Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer Scientific reports 10: 12016. 2020
• Puris, Elena; Gynther, Mikko; Auriola, Seppo; Huttunen, Kristiina. 2020. L-Type amino acid transporter 1 as a target for drug delivery Pharmaceutical research 37 5: 88. 2020
• Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia. 2020. Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles Cancers 12 11: 3292. 2020
• Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. 2020. Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up Alcoholism-clinical and experimental research 44 12: 2457-2467. 2020
• Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells Acs chemical neuroscience 11 24: 4301-4315. 2020
• Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. Caffeine content in newborn hair correlates with maternal dietary intake European journal of nutrition 2021; 60: 193-201. 2020
• Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. 2020. Side-stream products of malting: a neglected source of phytochemicals npj science of food 4 1: 21. 2020
• Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing Molecular pharmaceutics 17 6: 1945-1953. 2020
• Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery Journal of controlled release 327: 584-594. 2020
• Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M. 2019. Metabolic signature of extracellular vesicles depends on the cell culture conditions Journal of extracellular vesicles 8 1: 1596669. 2019
• Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET) American journal of clinical nutrition 110 5: 1108-1118. 2019
• Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C M; Auriola, Seppo; Harnmarlund-Udenaes, Margareta; Huttunen, Kristiina M; Loryan, Irena. 2019. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets Molecular pharmaceutics 16 7: 3261-3274. 2019
• Puris, E; Gynther, M; Huttunen, J; Auriola, S; Huttunen, KM. 2019. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery European journal of pharmaceutical sciences 129: 99-109. 2019
• Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180 Toxicology and applied pharmacology 370: 56-64. 2019
• Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. 2019. Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation Microbiome 7: 103. 2019
• Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. 2019. Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood Hormone research in paediatrics 91: 329-335. 2019
• Knuuttila, Emma; Riikonen, Jarno; Syvälä, Heimo; Auriola, Seppo; Murtola, Teemu J. 2019. Access and concentrations of atorvastatin in the prostate in men with prostate cancer Prostate 79 12: 1427-1434. 2019
• Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Metabolism of Scoparone in Experimental Animals and Humans Planta medica 85 06: 453-464. 2019
• Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia Scientific reports 9: 12860. 2019
• Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics Molecular pharmaceutics 16 9: 3968-3976. 2019
• Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND REPRODUCTIVE BIOLOGY 223: 79-84. 2018
• Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals Nutrition and diabetes 8: 35. 2018
• Tangen, IL; Fasmer, KE; Konings, GF; Jochems, A; Delvoux, B; Xanthoulea, S; Stokowy, T; Strand, E; Berg, HF; Auriola, S; Trovik, J; Häkkinen, MR; Haldorsen, IS. 2018. Blood steroids are associated with prognosis and fat distribution in endometrial cancer GYNECOLOGIC ONCOLOGY 2019; 152 1: 46-52. 2018
• Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort. DIABETOLOGIA 61 4: 849-861. 2018
• Mohammed, Ali Mustafa; Karttunen, Vesa; Huuskonen, Pasi; Huovinen, Marjo; Auriola, Seppo; Vähäkangas, Kirsi. 2018. Transplacental Transfer and Metabolism of Diuron in Human Placenta TOXICOLOGY LETTERS 295: 307-313. 2018
• Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. 2018. Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase Bioorganic chemistry 80: 655-667. 2018
• Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage Brain, behavior, and immunity 73: 670-681. 2018
• Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake INTERNATIONAL JOURNAL OF PHARMACEUTICS 544 1: 91-99. 2018
• Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes Scientific reports 8: 13036. 2018
• Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. Diets rich in whole grains increase betainized compounds associated with glucose metabolism American journal of clinical nutrition 108 5: 971-979. 2018
• Konings, GF; Saarinen, N; Delvoux, B; Kooreman, L; Koskimies, P; Krakstad, C; Fasmer, KE; Haldorsen, IS; Zaffagnini, A; Häkkinen, MR; Auriola, S; Dubois, L; Lieuwes, N; Verhaegen, F; Schyns, LE; Kruitwagen, RF; Xanthoulea, S; Romano, A. 2018. Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19 9: 2547. 2018
• Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants Scientific reports 8: 14616. 2018
• Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. 2018. Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 152: 165-172. 2018
• Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. 2018. Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2019; 164: 642-652. 2018
• Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes PHARMACEUTICAL RESEARCH 2019; 36: 17. 2018
• Airaksinen, Kaisa; Jokkala, Jenna; Ahonen, Ilmari; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Tiihonen, Kirsti. 2018. High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice Molecular Nutrition & Food Research 62 23: 1800455. 2018
• Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model. JOURNAL OF PHARMACEUTICAL SCIENCES 106 9: 2463-2471. 2017
• Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. 2017. Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig. Molecular Pharmaceutics 14 11: 3729-3738. 2017
• Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. 2017. Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts. AMERICAN JOURNAL OF PATHOLOGY 2018; 188 1: 216-228. 2017
• Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. JOURNAL OF MEDICINAL CHEMISTRY 60 23: 9885-9904. 2017
• Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. 2017. Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals Planta Medica 2018; 84 5: 320-328. 2017
• de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports 7: 46337. 2017
• Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells. JOURNAL OF CONTROLLED RELEASE 251: 37-48. 2017
• Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2016. Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics. ALCOHOL 52: 63-70. 2016
• Nerdal Patrik T, Peters Christian, Oberg Hans-Heinrich, Zlatev Hristo, Lettau Marcus, Quabius Elgar S, Sousa Sofia, Gonnermann Daniel, Auriola Seppo, Olive Daniel, Määttä Jorma, Janssen Ottmar, Kabelitz Dieter. 2016. Butyrophilin 3A/CD277-Dependent Activation of Human gamma delta T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. JOURNAL OF IMMUNOLOGY (BALTIMORE) 197: 3059-3068. 2016
• Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling. Molecular Pharmaceutics 13 4: 1358-1365. 2016
• Zlatev Hristo P, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma A. 2016. Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 86: 58-66. 2016
• Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome. PLOS ONE [ONLINE] 10 4: e0124379. 2015
• Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2015. Human placental cell and tissue uptake of doxorubicin and its liposomal formulations. TOXICOLOGY LETTERS 239 2: 108-114. 2015
• Sousa Sofia, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma. 2015. Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 15 4: 1-11. 2015
• Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. 2015. Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites. Toxicology Reports 2: 1024-1032. 2015
• Huuskonen Pasi, Auriola Seppo, Pasanen Markku. 2015. Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1. PLACENTA (LONDON) 36 9: 1052-1055. 2015
• Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling. Molecular Nutrition & Food Research [epub ahead of print 10 SEP 2015]: -. 2015
• Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes. XENOBIOTICA (LONDON) 2016; 46 1: 14-24. 2015
• Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. 2014. Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 2015; 22: 538-550. 2014
• Wang Chang-Fang, Auriola Seppo, Hirvonen Jouni, Santos Hélder A. 2014. Conjugation of peptides to antisense interleukin-6 via click chemistry. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 21: 1247-1254. 2014
• Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. 2014. Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS. PHYTOCHEMICAL ANALYSIS 25: 220-228. 2014
• Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2014. Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS. FOOD CHEMISTRY 165: 499-505. 2014
• Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Koivisto Heta, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2014. Quantitative Evaluation of Intracellular Distribution and Human Placental Transfer of Doxorubicin and its Liposomal Formulations: -, Conference Book: The Globalization of Pharmaceutics Education Network. -. 2014
• Landreh Luise, Spinnler Katrin, Schubert Kerstin, Häkkinen Merja R, Auriola Seppo, Poutanen Matti, Söder Olle, Svechnikov Konstantin, Mayerhofer Artur. 2014. Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 99: E1227-E1235. 2014
• Määttä Jorma, Mönkkönen Jukka, Auriola Seppo, Sousa Sofia, Zlatev Hristo, Arkko Satu. 2014. Bisphosphonate research. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 30 3: 199. 2014
• Knuuttila Matias, Yatkin Emrah, Kallio Jenny, Savolainen Saija, Laajala Teemu D, Aittokallio Tero, Oksala Riikka, Häkkinen Merja, Keski-Rahkonen Pekka, Auriola Seppo, Poutanen Matti, Mäkelä Sari. 2014. Castration Induces Up-Regulation of Intratumoral Androgen Biosynthesis and Androgen Receptor Expression in an Orthotopic VCaP Human Prostate Cancer Xenograft Model. AMERICAN JOURNAL OF PATHOLOGY 184: 2163-2173. 2014
• Huhtinen Kaisa, Saloniemi-Heinonen Taija, Keski-Rahkonen Pekka, Desai Reena, Laajala Daniel, Ståhle Mia, Häkkinen Merja R, Awosanya Michael, Suvitie Pia, Kujari Harry, Aittokallio Tero, Handelsman David J, Auriola Seppo, Perheentupa Antti, Poutanen Matti. 2014. Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 99: E2188-E2197. 2014
• Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol. CHEMICAL RESEARCH IN TOXICOLOGY 27: 1950-1957. 2014
• Ebert Regina, Meissner-Weigl Jutta, Zeck Sabine, Määttä Jorma, Auriola Seppo, Coimbra de Sousa Sofia, Mentrup Birgit, Graser Stephanie, Rachner Tilman D, Hofbauer Lorenz C, Jakob Franz. 2014. Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells. Molecular Cancer 13: 265. 2014
• Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. TOXICOLOGY IN VITRO 27 6: 2005-2012. 2013
• Wang Chang-Fang, Auriola Seppo, Hirvonen Jouni, Santos Hélder A. 2013. Peptides conjugated to antisense interleukin-6 by click chemistry. CURRENT MEDICINAL CHEMISTRY (SCHIPHOL) 2014:21 10: 1247-1254. 2013
• Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 941: 81-89. 2013
• Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. Molecular Nutrition & Food Research 57: 1959-1968. 2013
• Keski-Rahkonen Pekka, Huhtinen Kaisa, Desai Reena, Harwood D. Tim, Handelsman David J, Poutanen Matti, Auriola Seppo. 2013. LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization. JOURNAL OF MASS SPECTROMETRY 48: 1050-1058. 2013
• Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells. Huuskonen Pasi, Storvik Markus, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku / 48th Congress of the European Societies of Toxicology (EUROTOX), Stockholm, Sweden, 17th-20th June 2012. 2012. 2012
• Ahonen Linda, Keski-Rahkonen Pekka, Saarelainen Taija, Paviala Jenni, Ketola Raimo A, Auriola Seppo, Poutanen Matti, Kostiainen Risto. 2012. Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids ANALYTICA CHIMICA ACTA (AMSTERDAM) 721: 115-121. 2012
• Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS AMINO ACIDS 42: 451-460. 2012
• Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012
• Karttunen Vesa, Veid Jenni, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. 2012. Acute effects of ethanol on transplacental transfer. Teoksessa: (toim.), 48th Congress of the European Societies of Toxicology (EUROTOX), Stockholm, Sweden, 17th-20th June 2012. ss. 211S:S186. 2012
• Knuuttila Matias, Yatkin E, Kallio J, Savolainen S, Auriola Seppo, Poutanen M, Mäkelä S. 2012. Intratumor Androgen Biosynthesis in VCaP Xenografts - A model for Castration-Resistant Prostate Cancer. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:318. 2012
• Partanen Heidi, Vähäkangas Kirsi, Woo Chit SJ, Auriola Seppo, Veid Jenni, Chen Y, Myllynen Päivi, El Nezami Hani. 2012. Transplacental transfer of melamine PLACENTA (LONDON) 33: 60-66. 2012
• Repo Jenni, Soininen Suvi K, Meftah Azin, Auriola Seppo, Ruponen Marika, Vähäkangas Kirsi. 2012. Human Placental Perfusions of Anticancer Drug Doxorubicin and Liposomes Encapsulated with Doxorubicin. Teoksessa: (toim.), FinPharma Doctoral Program (FPDP): 6th Joint Meeting at the University of Turku, August 16-17, 2012, Turku, Finland. ss. 28:328. 2012
• Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics. DRUG METABOLISM AND DISPOSITION 39 3: 412 - 418. 2011
• Veid Jenni, Karttunen Vesa, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. 2011. Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. TOXICOLOGY LETTERS 205: 257-264. 2011
• Valo Hanna, Kovalainen Miia, Laaksonen Päivi, Häkkinen Merja, Auriola Seppo, Peltonen Leena, Linder Markus, Järvinen Kristiina, Hirvonen Jouni, Laaksonen Timo. 2011. Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices - Enhanced stability and release JOURNAL OF CONTROLLED RELEASE 156: 390-397. 2011
• Storvik Markus, Huuskonen Pasi, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku. 2011. Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells. TOXICOLOGY LETTERS 202: 161 - 167. 2011
• Keski-Rahkonen Pekka, Huhtinen Kaisa, Poutanen Matti, Auriola Seppo. 2011. Fast and sensitive liquid chromatography-mass spectometry assay for seven androgenic and progestagenic steroids in human serum JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 127: 396-404. 2011
• Räikkönen Johanna, Taskinen Markku, Dunford James E, Mönkkönen Hannu, Auriola Seppo, Mönkkönen Jukka. 2011. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407: 663-667. 2011
• Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. 2011. Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 879: 677 - 694. 2011
• Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. 2011. d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry TOXICOLOGY IN VITRO 25: 411 - 425. 2011
• Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. 2011. 2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites TOXICOLOGY LETTERS 207: 34-41. 2011
• Stenman SM, Lindfors K, Venäläinen JI, Hautala A, Männistö PT, Garcia-Horsman JA, Kaukovirta-Norja A, Auriola S, Mauriala T, Mäki M et al. 2010. Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 161: 242-249. 2010
• Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010. Proteomic study of zinc accumulation and tolerance in metal hyperaccumulator plant Thlaspi caerulescens, 4th Annual FinnProt Symposium "Quantitative Proteomics" April 14th-16th 2010, Abstract book. 11. 2010
• Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen K, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010. Proteomics of Thlaspi caerulescens accessions and inter-accession cross segregating for zinc accumulation, Reports and studies in forestry and natural sciences: IX Finnish SYmposium on Plant Science, May 17-19, Joensuu, Finland. 80. 2010
• Tuomainen M, Tervahauta A, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Häyrinen J, Auriola S, Anttonen M & Kärenlampi S. 2010. Proteomics of Thlaspi caerulescens accessions and an inter-accession cross segregating for zinc accumulation. JOURNAL OF EXPERIMENTAL BOTANY 61 4: 1075-1087. 2010
• Anttonen MJ, Lehesranta S, Auriola S, Röhlig RM, Engel K-H & Kärenlampi SO. 2010. Genetic and environmental influence on maize kernel proteome. JOURNAL OF PROTEOME RESEARCH 9 12: 6160-6168. 2010
• Räikkönen J, Mönkkönen H, Auriola S & Mönkkönen J. 2010. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. BIOCHEMICAL PHARMACOLOGY 79: 777 - 783. 2010
• Koskela, A., Anttonen, M., Soininen, T., Saviranta, N., Auriola, S., Julkunen-Tiitto, R. and Karjalainen, R.. 2010. Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58 23: 12289-12295. 2010
• Koskela Ali, Anttonen Mikko, Soininen Tuula, Auriola Seppo, Julkunen-Tiitto Riitta, Karjalainen Reijo. 2010. Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations. Teoksessa: (toim.), XXV International conference on polyphenols: polyphenols communications 2010 volume 2. ss. 552-553. 2010
• Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases. AMINO ACIDS 38: 369-381. 2010
• Mitrofan LM, Auriola S, Mönkkönen H & Mönkkönen J. 2010. Assessment of bisphosphonate activity in vitro CURRENT PHARMACEUTICAL DESIGN 16 27: 2970-2980. 2010
• Matilainen L, Maunu SL, Pajander J, Auriola S, Jääskeläinen I, Lambertsen Larsen K, Järvinen T, Jarho P. 2009. The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 36: 412-420. 2009
• Stenman SM, Venäläinen JI, Lindfors K, Auriola S, Mauriala T, Kaukovirta-Norja A, Jantunen A, Laurila K, Qiao S-W, Sollid LM, Männistö PT, Kaukinen K, Mäki M. 2009. Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease. Annals of Medicine 41: 390-400. 2009
• Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J. 2009. Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro BRITISH JOURNAL OF PHARMACOLOGY 157: 427-435. 2009
• Qu C-J, Pöytäkangas T, Jauhiainen M, Auriola S, Lammi MJ. 2009. Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension. CELL AND TISSUE RESEARCH 337: 103-111. 2009
• Mannila J, Järvinen K, Holappa J, Matilainen L, Auriola S, Jarho P. 2009. Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate INTERNATIONAL JOURNAL OF PHARMACEUTICS 381: 19-24. 2009
• Laine JE, Auriola S, Pasanen M, Juvonen RO. 2009. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes XENOBIOTICA (LONDON) 39 1: 11-21. 2009
• Keski-Rahkonen P, Haapala M, Saarela V, Franssila S, Kotiaho T, Kostiainen R, Auriola S. 2009. Atmospheric pressure thermospray ionization using a heated microchip nebulizer. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 23: 3313-3322. 2009
• Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. 2009. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877: 2967-2975. 2009
• Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Synthesis of novel deuterium labelled derivates of N-alkylated polyamines. TETRAHEDRON 65 2: 547-562. 2009
• Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J. 2008. Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. ANTI-CANCER DRUGS 19: 391-399. 2008
• Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. CLINICAL AND EXPERIMENTAL ALLERGY 38: 374-381. 2008
• Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo XENOBIOTICA (LONDON) 38 1: 34-47. 2008
• Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH. 2008. Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats. PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 456: 369-377. 2008
• Pulkkinen M, Palmgrén JJ, Auriola S, Malin M, Seppälä J, Järvinen K. 2008. High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 22: 121-129. 2008
• Matilainen L, Lambertsen Larsen K, Wimmer R, Keski-Rahkonen P, Auriola S, Järvinen T, Jarho P. 2008. The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes JOURNAL OF PHARMACEUTICAL SCIENCES 97 7: 2720-2729. 2008
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 48: 414-421. 2008
• Koponen JM, Happonen AM, Auriola S, Kontkanen H, Buchert J, Poutanen KS, Törrönen R, Koponen JM, Happonen AM, Poutanen KS, Törrönen R. 2008. Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56: 3136-3144. 2008
• Jokela TA, Jauhiainen M, Auriola S, Kauhanen M, Tiihonen R, Tammi MI, Tammi RH. 2008. Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines. JOURNAL OF BIOLOGICAL CHEMISTRY 283 12: 7666-7673. 2008
• Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. CHEMISTRY & BIODIVERSITY 5: 2431-2441. 2008
• Garcia-Horsman JA, Venäläinen JI, Lohi O, Auriola IS, Korponay-Szabo IR, Kaukinen K, Mäki M, Männistö PT. 2007. Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 42: 562-571. 2007
• Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 45: 625-634. 2007
• Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. 2007. Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 21 18: 2933-2943. 2007
• Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 43: 606-612. 2007
• Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden JOURNAL OF NEUROSCIENCE 27 14: 3712-3721. 2007
• Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. 2007. Zoledronic acid-induced IPP/ApppI production in vivo LIFE SCIENCES 81: 1066-1070. 2007
• Qu C-J, Jauhianen M, Auriola S , Helminen Heikki J, Lammi MJ. 2007. Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes. OSTEOARTHRITIS AND CARTILAGE 15: 773-779. 2007
• Tuomainen MH, Nunan N, Lehesranta SJ, Tervahauta AI, Hassinen VH, Schat H, Koistinen KM, Auriola S, McNicol J, Kärenlampi SO. 2006. Multivariate analysis of protein profiles of metal hyperaccumulator Thlaspi caerulescens accessions. PROTEOMICS 6: 3696-3706. 2006
• Matilainen L, Järvinen K, Toropainen T, Näsi E, Auriola S, Järvinen T, Jarho P. 2006. In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A. INTERNATIONAL JOURNAL OF PHARMACEUTICS 318: 41-48. 2006
• Palmgrén JJ, Mönkkönen J, Korjamo T, Hassinen A, Auriola S. 2006. Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 64: 369-378. 2006
• Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates BRITISH JOURNAL OF PHARMACOLOGY 147: 437-445. 2006
• Cuypers A, Koistinen KM, Kokko H, Kärenlampi S, Auriola S, Vangronsveld J. 2005. Analysis of bean (Phaseolus vulgaris L.) proteins affected by copper stress JOURNAL OF PLANT PHYSIOLOGY 162: 383-392. 2005
• Korolainen MA, Auriola S, Nyman TA, Alafuzoff I, Pirttilä T, Korolainen MA, Pirttilä T. 2005. Proteomic analysis of glial fibrillary acidic protein in Alzheimer¿s disease and aging brain. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 20: 858-870. 2005
• Lehesranta SJ, Davies HV, Shepherd LVT, Nunan N, McNicol JW, Auriola S, Koistinen KM, Suomalainen S, Kokko HI, Kärenlampi SO. 2005. Comparison of tuber proteomes of potato varieties, landraces, and genetically modified lines PLANT PHYSIOLOGY 138: 1690-1699. 2005
• Palmgrén JJ, Töyräs A, Mauriala T, Mönkkönen J, Auriola S. 2005. Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 821: 144-152. 2005
• Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. 2005. Isolation and characterization of yuremamine, a new phytoindole. PLANTA MEDICA 71: 1053-1057. 2005
• Tennilä T, Ketomäki K, Penttinen P, Tengvall U, Azhayeva E, Auriola S, Lönnberg H, Azhayev A. 2004. Selective circular oligonucleotide probes improve detection of point mutations in DNA CHEMISTRY & BIODIVERSITY 1 4: 609-625. 2004
• Mauriala T, Herzig KH, Heinonen M, Idziak J, Auriola S. 2004. Determination of long-chain fatty acid acyl-coenzyme A compounds using liquid chromatography-electrospray ionization tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 808 2: 263-268. 2004
• Palmgrén J, Mönkkönen J, Jukkola E, Niva S, Auriola S. 2004. Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 57: 319-328. 2004
• Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy CLINICAL AND EXPERIMENTAL ALLERGY 34: 1576-1582. 2004
• Mauriala T, Auriola S, Azhayev A, Kayushin A, Korosteleva M, Miroshnikov A. 2004. HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 34: 199-206. 2004
• Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach. NEUROSCIENCE LETTERS 367 2: 235-240. 2004
• Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. 2004. Effects of triaryl phosphates on mouse and human nuclear receptors BIOCHEMICAL PHARMACOLOGY 67: 97-106. 2004
• Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. The microglia-activating potential of thrombin. JOURNAL OF BIOLOGICAL CHEMISTRY 279 50: 51880-51887. 2004
• Kärkkäinen M, Raunio P, Rautiainen J, Auriola S, Hinke K, Pasanen A-L. 2004. Partial amino acid sequence of a cellullase-like component with IgE-binding properties from stachybotrys chartarum. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 133: 136-144. 2004
• Kostiainen R, Kotiaho T, Kuuranne T, Auriola S. 2003. Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies. JOURNAL OF MASS SPECTROMETRY 38: 357-372. 2003
• Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 19: 23-29. 2003
• Tengvall U, Auriola S, Antopolsky M, Azhayev A, Biegelman L. 2003. Characterization of antisense oligonucleotide-peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography-mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 32: 581-590. 2003
• Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 20: 99-106. 2003
• Niittynen M, Tuomisto JT, Auriola S, Pohjanvirta R, Syrjälä P, Simanainen U, Viluksela M, Tuomisto J. 2002. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats. TOXICOLOGICAL SCIENCES 71: 112-123. 2002
• Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 772: 81-87. 2002
• Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols. JOURNAL OF CHROMATOGRAPHY A 976: 165-170. 2002
• Niiranen H, Budnik BA, Zubarev RA, Auriola S, Lapinjoki S. 2002. High-performance liquid chromatography-mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin determination of gamma-carboxyglutamic acid residues JOURNAL OF CHROMATOGRAPHY A 962: 95-103. 2002
• Nieminen SM, Kärki R, Auriola S, Toivola M, Laatsch H, Laatikainen R, Hyvärinen A, Von Wright A. 2002. Isolation and identification of Aspergillus fumigatus mycotoxins on growth medium and some building materials. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 68 10: 4871-4875. 2002
• Koistinen KM, Kokko HI, Hassinen VH, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. Stress-related RNase PR-10c is post-translationally modified by glutathione in birch. PLANT, CELL AND ENVIRONMENT 25: 707-715. 2002
• Koistinen KM, Hassinen VH, Gynther PAM, Lehesranta SJ, Keinänen SI, Kokko HI, Oksanen EJ, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. Birch PR-10c is induced by factors causing oxidative stress but appears not to confer tolerance to these agents. NEW PHYTOLOGIST 155: 381-391. 2002
• El-Nezami HS, Chrevatidis A, Auriola S, Salminen S, Mykkänen H. 2002. Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. FOOD ADDITIVES AND CONTAMINANTS 19: 680-686. 2002
• Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. 2001. The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate ARTHRITIS AND RHEUMATISM 44 9: 2201-2210. 2001
• Mönkkönen H, Rogers MJ, Makkonen N, Niva S, Auriola S, Mönkkönen J. 2001. The cellular uptake and metabolism of clodronate in RAW 264 macrophages. PHARMACEUTICAL RESEARCH 18 11: 1550-1555. 2001
• Rautiainen J, Auriola S, Konttinen A, Virtanen T, Rytkönen-Nissinen M, Zeiler T, Mäntyjärvi R. 2001. Two new variants of the lipocalin allergen Bos d 2 JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 763: 91-98. 2001
• Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells. JOURNAL OF CELLULAR BIOCHEMISTRY 79: 610-619. 2000
• Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 9: 265-270. 2000
• Mönkkönen H, Moilanen P, Mönkkönen J, Frith JC, Rogers MJ, Auriola S. 2000. Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 738: 395-403. 2000
• Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. 2000. Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes ARCHIVES OF TOXICOLOGY 74: 511-520. 2000
• Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RGG. 1999. Molecular mechanisms of action of bisphosphonates. BONE 24 5: 73S-79S. 1999
• Vähätalo H, Auriola S, Lapinjoki S. 1999. High-performance liquid chromatography-mass spectrometry of an osteocalcin derivative. JOURNAL OF CHROMATOGRAPHY A 846: 49-57. 1999
• Toroskainen C, Auriola S. 1999. Antibioottiset peptidit DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 15 1: 12-22. 1999
• Auriola S, Monkkonen H, Frith J, Rogers M, Monkkonen J. 1999. Analysis of adenine nucleotide containing metabolite of clodronate using ion pair HPLC-ESI-MS, The 47th ASMS Conference on Mass Spectrometry And Allied Topics. Proceedings. [CD-ROM]. 1999
• Mönkkönen J, Makkonen N, Rogers MJ, Frith JC, Auriola S. 1999. Effects of bisphosphonates on the inflammatory processes of activated macrophages. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS 144-146: 321-324. 1999
• Benford HL, Frith JC, Auriola S, Mönkkönen J, Rogers MJ. 1999. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. MOLECULAR PHARMACOLOGY 56: 131-140. 1999
• Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. 1999. Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties. BIOCONJUGATE CHEMISTRY 10 4: 598-606. 1999
• Hakala K, Auriola S, Koivisto A, Lönnberg H. 1999. Mass spectrometric (HPLC/ESI-MS/MS) quantification of pyrimido[1,2-a]purin-10(3H)-one, a guanine adduct formed by reaction of malondialdehyde with DNA. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 21: 1053-1061. 1999
• Auriola S, Thibault P, Sadovskaya I, Altman E. 1998. Enhancement of sample loadings for the analysis of oligosaccharides isolated from pseudomonas aeruginosa using transient isotachophoresis and capillary zone electrophoresis - electrospray - mass spectrometry. ELECTROPHORESIS 19: 2665-2676. 1998
• Azhayev A, Auriola S, Hovinen J. 1998. New building blocks for the preparation of branched oligonucleotides NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS 17: 1527-1537. 1998
• Häkkinen S, Auriola S. 1998. High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries. JOURNAL OF CHROMATOGRAPHY A 829: 91-100. 1998
• Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro. JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 709: 1-10. 1998
• Rautiainen J, Auriola S, Rouvinen J, Kauppinen J, Zeiler T, Novikov D, Virtanen T, Mäntyjärvi RA. 1998. Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 247: 746-750. 1998
• Utriainen M, Kokko H, Auriola S, Sarrazin O, Kärenlampi S. 1998. PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula. PLANT, CELL AND ENVIRONMENT 21: 821-828. 1998
• Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. 1997. Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach JOURNAL OF CONTROLLED RELEASE 49: 97-104. 1997
• Ranta V-P, Urtti A, Auriola S. 1997. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection. JOURNAL OF CHROMATOGRAPHY A 766: 85-97. 1997
• Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. 1997. Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry, The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. 651. 1997
• Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. 1997. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 38 3: 627-634. 1997
• Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. 1997. Inhibitory properties of double helix forming circular oligonucleotides. NUCLEIC ACIDS RESEARCH 25 24: 4954-4961. 1997
• Auriola S, Frith J, Rogers MJ, Koivuniemi A, Mönkkönen J. 1997. Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry JOURNAL OF CHROMATOGRAPHY. B. ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 704: 187-195. 1997
• Auriola S, Jääskeläinen I, Regina M, Urtti A. 1996. Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns. ANALYTICAL CHEMISTRY 68 22: 3907-3911. 1996
• Manninen A, Auriola S, Vartiainen M, Liesivuori J, Turunen T, Pasanen M. 1996. Determination of urinary 2-mercaptobenzothiazole (2-MBT), the main metabolite of 2-(thiocyanomethylthio)benzothiazole (TCMTB) in humans and rats ARCHIVES OF TOXICOLOGY 70: 579-584. 1996
• Auriola S, Thibault P, Sadovskaya I, Masoud H, Altman E, Richards JC. 1995. CE-MS and MS-MS analyses of lipopolysaccharides from p.aeruginosa. Teoksessa: (toim.), Proceedings the 43rd ASMS Conference on Mass Spectrometry and Allied Topics. ss. 977. 1995
• Pirttilä T-RM, Auriola SOK, Kauppinen R. 1995. Glucose metabolism in the developing cerebral cortex as detected by 1H {13C} nuclear magnetic resonance spectroscopy ex vivo JOURNAL OF NEUROCHEMISTRY 64: 417-423. 1995
• Gibson BW, Medzihradszky D, Hines WM, Auriola S, Kenyon GL. 1994. Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 5: 443-451. 1994
• Kauppinen RA, Pirttilä T-RM, Auriola SOK, Williams SR. 1994. Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r. BIOCHEMICAL JOURNAL 298: 121-127. 1994