Seppo Auriola

Accelerated early childhood growth associates with the development of earlier adrenarche and puberty

Liimatta, Jani; Jääskeläinen, Jarmo; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Flück, Christa E; Lakka, Timo A. 2024. Journal of the Endocrine Society. 8: . bvae026 A1 Journal article (refereed), original research

Barcode lipids for absolute quantitation of liposomes in ocular tissues

Merivaara, Arto; Puranen, Jooseppi; Sadeghi, Amir; Zashikhina, Natalia; Pirskanen, Lea; Lajunen, Tatu; Terasaki, Tetsuya; Auriola, Seppo; Vellonen, Kati Sisko; Urtti, Arto. 2024. Journal of controlled release. 370: 1-13 A1 Journal article (refereed), original research

Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis

Abdolahpur Monikh, Fazel; Lehtonen, Šárka; Kekäläinen, Jukka; Karkossa, Isabel; Auriola, Seppo; Schubert, Kristin; Zanut, Alessandra; Peltonen, Sanni; Niskanen, Jonna; Bandekar, Mandar; von Bergen, Martin; Leskinen, Jari TT; Koistinen, Arto; Bogialli, Sara; Guo, Zhiling; Kukkonen, Jussi VK; Chen, Chunying; Lynch, Iseult. 2024. Nano today. 59: . 102466 A1 Journal article (refereed), original research

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: A1 Journal article (refereed), original research

Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence

Healy, Darren R; Zarei, Iman; Mikkonen, Santtu; Soininen, Sonja; Viitasalo, Anna; Haapala, Eero A; Auriola, Seppo; Hanhineva, Kati; Kolehmainen, Marjukka; Lakka, Timo A. 2024. Communications biology. 7: . 890 A1 Journal article (refereed), original research

Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study

Kettunen, Kimmo; Mathlin, Julia; Lamminen, Tarja; Laiho, Asta; Häkkinen, Merja R; Auriola, Seppo; Elo, Laura L; Boström, Peter J; Poutanen, Matti; Taimen, Pekka. 2024. EBioMedicine. 108: A1 Journal article (refereed), original research

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert. 2024. Frontiers in pharmacology. 15: . 1365051 A1 Journal article (refereed), original research

Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study

Ramsay, Eva; Montaser, Ahmed B; Niitsu, Kanako; Urtti, Arto; Auriola, Seppo; Huttunen, Kristiina M; Uchida, Yasuo; Kidron, Heidi; Terasaki, Tetsuya. 2024. Molecular pharmaceutics. 21: 3204-3217 A1 Journal article (refereed), original research

An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in IVF patients

Stevens Brentjens, LBPM; Obukhova, D; den Hartog, JE; Delvoux, B; Koskivuori, J; Auriola, S; Häkkinen, MR; Bui, B; van Hoogenhuijze, NE; Mackens, S; Mol, F; de Bruin, JP; Besselink, D; Teklenburg, G; Kukushkina, V; Salumets, A; Broekmans, FJM; van Golde, RJT; Zamani Esteki, M; Romano, A. 2023. F&S science. 4: 219-228 A1 Journal article (refereed), original research

Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Ozgür, Burak; Puris, Elena; Brachner, Andreas; Appelt-Menzel, Antje; Oerter, Sabrina; Balzer, Viktor; Holst, Mikkel Roland; Christiansen, Rasmus Folmann; Hyldig, Kathrine; Buckley, Stephen T; Kristensen, Mie; Auriola, Seppo; Jensen, Allan; Fricker, Gert; Nielsen, Morten Schallburg; Neuhaus, Winfried; Brodin, Birger. 2023. Fluids and barriers of the cns. 20: . 96 A1 Journal article (refereed), original research

Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232: A1 Journal article (refereed), original research

Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study

Liimatta, Jani; Flück, Christa E; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Jääskelainen, Jarmo; Lakka, Timo A. 2023. Journal of clinical endocrinology and metabolism. 108: e1603-e1613 A1 Journal article (refereed), original research

Farmaseuttinen kemia

Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo. 2023. Publications of the University of Eastern Finland. General series. 44: 32-35 E1 Popularised article, newspaper article

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

Häkkinen, Katja; Kiander, Wilma; Kidron, Heidi; Lähteenvuo, Markku; Urpa, Lea; Lintunen, Jonne; Vellonen, Kati Sisko; Auriola, Seppo; Holm, Minna; Lahdensuo, Kaisla; Kampman, Olli; Isometsä, Erkki; Kieseppä, Tuula; Lönnqvist, Jouko; Suvisaari, Jaana; Hietala, Jarmo; Tiihonen, Jari; Palotie, Aarno; Ahola-Olli, Ari V.; Niemi, Mikko. 2023. Molecular pharmaceutics. 20: 1500-1508 A1 Journal article (refereed), original research

In vitro identification of decreased function phenotype ABCG2 variants

Suominen, Laura; Sjöstedt, Noora; Vellonen, Kati-Sisko; Gynther, Mikko; Auriola, Seppo; Kidron, Heidi. 2023. European journal of pharmaceutical sciences. 188: A1 Journal article (refereed), original research

Mass spectrometry in ocular drug research

del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 A2 Review article, Literature review, Systematic review

Monoacylglycerol lipase inhibitor JJKK048 ameliorates ABCG2 transporter-mediated regorafenib resistance induced by hypoxia in triple negative breast cancer cells

Puris, Elena; Petralla, Sabrina; Auriola, Seppo; Kidron, Heidi; Fricker, Gert; Gynther, Mikko. 2023. Journal of pharmaceutical sciences. 112: 2581-2590 A1 Journal article (refereed), original research

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215: A1 Journal article (refereed), original research

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Journal article (refereed), original research

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Puris, Elena; Auriola, Seppo; Petralla, Sabrina; Hartman, Robin; Gynther, Mikko; de Lange, Elizabeth CM; Fricker, Gert. 2022. Neurobiology of disease. 169: A1 Journal article (refereed), original research

Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

Hugele, Agathe; Löffler, Susanne; Molina, Belén Hernández; Guillon, Melina; Montaser, Ahmed B.; Auriola, Seppo; Huttunen, Kristiina M.. 2022. Frontiers in pharmacology. 13: . 1034964 A1 Journal article (refereed), original research

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310: A1 Journal article (refereed), original research

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Wilma, Kiander; Noora, Sjöstedt; Riikka, Manninen; Liina, Jaakkonen; Kati-Sisko, Vellonen; Mikko, Neuvonen; Mikko, Niemi; Seppo, Auriola; Heidi, Kidron. 2022. European journal of pharmaceutical sciences. 176: A1 Journal article (refereed), original research

In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity

Šadibolová, Michaela; Juvonen, Risto O; Auriola, Seppo; Boušová, Iva. 2022. Archives of toxicology. 96: 793-808 A1 Journal article (refereed), original research

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Journal article (refereed), original research

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770 A1 Journal article (refereed), original research

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Journal article (refereed), original research

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease

Puris, Elena; Saveleva, Liudmila; de Sousa Maciel, Izaque; Kanninen, Katja M.; Auriola, Seppo; Fricker, Gert. 2022. Molecular neurobiology. 2023; 60: 732-748 A1 Journal article (refereed), original research

Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies

Balzer, Viktor; Poc, Pascal; Puris, Elena; Martin, Stefan; Aliasgari, Maryam; Auriola, Seppo; Fricker, Gert. 2022. European journal of pharmaceutics and biopharmaceutics. 173: 12-21 A1 Journal article (refereed), original research

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Journal article (refereed), original research

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

Constable, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Jääskeläinen, Jarmo; Voutilainen, Raimo; Auriola, Seppo; Häkkinen, Merja R.; Laitinen, Tomi; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 850448 A1 Journal article (refereed), original research

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 A1 Journal article (refereed), original research

A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. Metabolomics. 17: 20 A1 Journal article (refereed), original research

Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial

Raittinen, Paavo V.H.; Syvälä, Heimo; Tammela, Teuvo L.J.; Häkkinen, Merja R.; Ilmonen, Pauliina; Auriola, Seppo; Murtola, Teemu J.. 2021. EBioMedicine. 68: 103432 A1 Journal article (refereed), original research

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology. 26: e13035 A1 Journal article (refereed), original research

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo. 2021. Alcoholism-clinical and experimental research. 45: 2207-2216 A1 Journal article (refereed), original research

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. International journal of molecular sciences. 22: 7727 A1 Journal article (refereed), original research

PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche

Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Häkkinen, Merja; Auriola, Seppo; Morin-Papunen, Laure; Liimatta, Jani. 2021. Journal of clinical endocrinology and metabolism. 106: e3335-e3345 A1 Journal article (refereed), original research

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Pharmaceutics. 13: 658 A1 Journal article (refereed), original research

Pharmacological inhibition of 17ß-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model

Xanthoulea, Sofia; Konings, Gonda F.J.; Saarinen, Niina; Delvoux, Bert; Kooreman, Loes F.S.; Koskimies, Pasi; Häkkinen, Merja R.; Auriola, Seppo; D'Avanzo, Elisabetta; Walid, Youssef; Verhaegen, Frank; Lieuwes, Natasja G.; Caiment, Florian; Kruitwagen, Roy; ENITEC; Romano, Andrea. 2021. Cancer letters. 508: 18-29 A1 Journal article (refereed), original research

Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach

Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. 2021. Nutrition metabolism and cardiovascular diseases. 31: 1156-1165 A1 Journal article (refereed), original research

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences. 110: 3953-3962 A1 Journal article (refereed), original research

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi. 2021. Pharmaceutical research. 38: 1663-1675 A1 Journal article (refereed), original research

Caffeine content in newborn hair correlates with maternal dietary intake

Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. European journal of nutrition. 2021; 60: 193-201 A1 Journal article (refereed), original research

Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles

Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia. 2020. Cancers. 12: 3292 A1 Journal article (refereed), original research

Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up

Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. 2020. Alcoholism-clinical and experimental research. 44: 2457-2467 A1 Journal article (refereed), original research

Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer

Raittinen, Paavo; Niemistö, Kati; Pennanen, Erika; Syvälä, Heimo; Auriola, Seppo; Riikonen, Jarno; Lehtimäki, Terho; Ilmonen, Pauliina; Murtola, Teemu. 2020. Scientific reports. 10: 12016 A1 Journal article (refereed), original research

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. Acs chemical neuroscience. 11: 4301-4315 A1 Journal article (refereed), original research

L-Type amino acid transporter 1 as a target for drug delivery

Puris, Elena; Gynther, Mikko; Auriola, Seppo; Huttunen, Kristiina. 2020. Pharmaceutical research. 37: 88 A2 Review article, Literature review, Systematic review

Metabolome of canine and human saliva: a non-targeted metabolomics study

Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati. 2020. Metabolomics. 16: 90 A1 Journal article (refereed), original research

Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms

Noerman, S; Klåvus, A; Järvelä-Reijonen, E; Karhunen, L; Auriola, S; Korpela, R; Lappalainen, R; Kujala, UM; Puttonen, S; Kolehmainen, M; Hanhineva, K. 2020. Scientific reports. 10: 2143 A1 Journal article (refereed), original research

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Molecular pharmaceutics. 17: 1945-1953 A1 Journal article (refereed), original research

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery

Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Journal of controlled release. 327: 584-594 A1 Journal article (refereed), original research

Side-stream products of malting: a neglected source of phytochemicals

Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. 2020. npj science of food. 4: 21 A1 Journal article (refereed), original research

Access and concentrations of atorvastatin in the prostate in men with prostate cancer

Knuuttila, Emma; Riikonen, Jarno; Syvälä, Heimo; Auriola, Seppo; Murtola, Teemu J. 2019. Prostate. 79: 1427-1434 A1 Journal article (refereed), original research

Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood

Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. 2019. Hormone research in paediatrics. 91: 329-335 A1 Journal article (refereed), original research

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. 2019. Microbiome. 7: 103 A1 Journal article (refereed), original research

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976 A1 Journal article (refereed), original research

Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180

Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Toxicology and applied pharmacology. 370: 56-64 A1 Journal article (refereed), original research

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. Scientific reports. 9: 12860 A1 Journal article (refereed), original research

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

Puris, E; Gynther, M; Huttunen, J; Auriola, S; Huttunen, KM. 2019. European journal of pharmaceutical sciences. 129: 99-109 A1 Journal article (refereed), original research

Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C M; Auriola, Seppo; Harnmarlund-Udenaes, Margareta; Huttunen, Kristiina M; Loryan, Irena. 2019. Molecular pharmaceutics. 16: 3261-3274 A1 Journal article (refereed), original research

Metabolic signature of extracellular vesicles depends on the cell culture conditions

Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M. 2019. Journal of extracellular vesicles. 8: 1596669 A1 Journal article (refereed), original research

Metabolism of Scoparone in Experimental Animals and Humans

Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Planta medica. 85: 453-464 A1 Journal article (refereed), original research

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition. 110: 1108-1118 A1 Journal article (refereed), original research

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports. 8: 14616 A1 Journal article (refereed), original research

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology. 223: 79-84 A1 Journal article (refereed), original research

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Pharmaceutical research. 2019; 36: 17 A1 Journal article (refereed), original research

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue

Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. 2018. Journal of pharmaceutical and biomedical analysis. 152: 165-172 A1 Journal article (refereed), original research

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35 A1 Journal article (refereed), original research

Blood steroids are associated with prognosis and fat distribution in endometrial cancer

Tangen, IL; Fasmer, KE; Konings, GF; Jochems, A; Delvoux, B; Xanthoulea, S; Stokowy, T; Strand, E; Berg, HF; Auriola, S; Trovik, J; Häkkinen, MR; Haldorsen, IS. 2018. Gynecologic oncology. 2019; 152: 46-52 A1 Journal article (refereed), original research

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

Konings, GF; Saarinen, N; Delvoux, B; Kooreman, L; Koskimies, P; Krakstad, C; Fasmer, KE; Haldorsen, IS; Zaffagnini, A; Häkkinen, MR; Auriola, S; Dubois, L; Lieuwes, N; Verhaegen, F; Schyns, LE; Kruitwagen, RF; Xanthoulea, S; Romano, A. 2018. International journal of molecular sciences. 19: 2547 A1 Journal article (refereed), original research

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979 A1 Journal article (refereed), original research

Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase

Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. 2018. Bioorganic chemistry. 80: 655-667 A1 Journal article (refereed), original research

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681 A1 Journal article (refereed), original research

High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice

Airaksinen, Kaisa; Jokkala, Jenna; Ahonen, Ilmari; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Tiihonen, Kirsti. 2018. Molecular nutrition and food research. 62: 1800455 A1 Journal article (refereed), original research

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort

Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia. 61: 849-861 A1 Journal article (refereed), original research

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue

Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. 2018. Journal of pharmaceutical and biomedical analysis. 2019; 164: 642-652 A1 Journal article (refereed), original research

Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake

Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. International journal of pharmaceutics. 544: 91-99 A1 Journal article (refereed), original research

Transplacental Transfer and Metabolism of Diuron in Human Placenta

Mohammed, Ali Mustafa; Karttunen, Vesa; Huuskonen, Pasi; Huovinen, Marjo; Auriola, Seppo; Vähäkangas, Kirsi. 2018. Toxicology letters. 295: 307-313 A1 Journal article (refereed), original research

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes

Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 A1 Journal article (refereed), original research

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts

Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. 2017. American journal of pathology. 2018; 188: 216-228 A1 Journal article (refereed), original research

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Journal of medicinal chemistry. 60: 9885-9904 A1 Journal article (refereed), original research

Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals

Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. 2017. Planta medica. 2018; 84: 320-328 A1 Journal article (refereed), original research

Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells

Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Journal of controlled release. 251: 37-48 A1 Journal article (refereed), original research

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model

Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Journal of pharmaceutical sciences. 106: 2463-2471 A1 Journal article (refereed), original research

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337 A1 Journal article (refereed), original research

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. 2017. Molecular pharmaceutics. 14: 3729-3738 A1 Journal article (refereed), original research

Butyrophilin 3A/CD277-Dependent Activation of Human gamma delta T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations

Nerdal Patrik T, Peters Christian, Oberg Hans-Heinrich, Zlatev Hristo, Lettau Marcus, Quabius Elgar S, Sousa Sofia, Gonnermann Daniel, Auriola Seppo, Olive Daniel, Määttä Jorma, Janssen Ottmar, Kabelitz Dieter. 2016. Journal of immunology. 197: 3059-3068 A1 Journal article (refereed), original research

Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics

Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2016. Alcohol. 52: 63-70 A1 Journal article (refereed), original research

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling

Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365 A1 Journal article (refereed), original research

Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells

Zlatev Hristo P, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma A. 2016. European journal of pharmaceutical sciences. 86: 58-66 A1 Journal article (refereed), original research

CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome

Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE. 10: e0124379 A1 Journal article (refereed), original research

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. 2015. Toxicology reports. 2: 1024-1032 A1 Journal article (refereed), original research

Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling

Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Molecular nutrition and food research. [epub ahead of print 10 SEP 2015]: - A1 Journal article (refereed), original research

Human placental cell and tissue uptake of doxorubicin and its liposomal formulations

Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2015. Toxicology letters. 239: 108-114 A1 Journal article (refereed), original research

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes

Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Xenobiotica. 2016; 46: 14-24 A1 Journal article (refereed), original research

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells

Sousa Sofia, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma. 2015. Bmc cancer. 15: 1-11 A1 Journal article (refereed), original research

Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1

Huuskonen Pasi, Auriola Seppo, Pasanen Markku. 2015. Placenta. 36: 1052-1055 A1 Journal article (refereed), original research

Bisphosphonate research

Määttä Jorma, Mönkkönen Jukka, Auriola Seppo, Sousa Sofia, Zlatev Hristo, Arkko Satu. 2014. Dosis. 30: 199 B1 Non-refereed journal articles

Castration Induces Up-Regulation of Intratumoral Androgen Biosynthesis and Androgen Receptor Expression in an Orthotopic VCaP Human Prostate Cancer Xenograft Model

Knuuttila Matias, Yatkin Emrah, Kallio Jenny, Savolainen Saija, Laajala Teemu D, Aittokallio Tero, Oksala Riikka, Häkkinen Merja, Keski-Rahkonen Pekka, Auriola Seppo, Poutanen Matti, Mäkelä Sari. 2014. American journal of pathology. 184: 2163-2173 A1 Journal article (refereed), original research

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity

Landreh Luise, Spinnler Katrin, Schubert Kerstin, Häkkinen Merja R, Auriola Seppo, Poutanen Matti, Söder Olle, Svechnikov Konstantin, Mayerhofer Artur. 2014. Journal of clinical endocrinology and metabolism. 99: E1227-E1235 A1 Journal article (refereed), original research

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Chemical research in toxicology. 27: 1950-1957 A1 Journal article (refereed), original research

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions

Huhtinen Kaisa, Saloniemi-Heinonen Taija, Keski-Rahkonen Pekka, Desai Reena, Laajala Daniel, Ståhle Mia, Häkkinen Merja R, Awosanya Michael, Suvitie Pia, Kujari Harry, Aittokallio Tero, Handelsman David J, Auriola Seppo, Perheentupa Antti, Poutanen Matti. 2014. Journal of clinical endocrinology and metabolism. 99: E2188-E2197 A1 Journal article (refereed), original research

Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. 2014. Phytochemical analysis. 25: 220-228 A1 Journal article (refereed), original research

Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells

Ebert Regina, Meissner-Weigl Jutta, Zeck Sabine, Määttä Jorma, Auriola Seppo, Coimbra de Sousa Sofia, Mentrup Birgit, Graser Stephanie, Rachner Tilman D, Hofbauer Lorenz C, Jakob Franz. 2014. Molecular cancer. 13: 265 A1 Journal article (refereed), original research

Quantitative Evaluation of Intracellular Distribution and Human Placental Transfer of Doxorubicin and its Liposomal Formulations

Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Koivisto Heta, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2014. -

Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2014. Food chemistry. 165: 499-505 A1 Journal article (refereed), original research

Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools

Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. 2014. Current medicinal chemistry. 2015; 22: 538-550 A2 Review article, Literature review, Systematic review

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS

Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 941: 81-89 A1 Journal article (refereed), original research

Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach

Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research. 57: 1959-1968 A1 Journal article (refereed), original research

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Toxicology in vitro. 27: 2005-2012 A1 Journal article (refereed), original research

LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization

Keski-Rahkonen Pekka, Huhtinen Kaisa, Desai Reena, Harwood D. Tim, Handelsman David J, Poutanen Matti, Auriola Seppo. 2013. Journal of mass spectrometry. 48: 1050-1058 A1 Journal article (refereed), original research

Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine

Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Dosis

Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids

Ahonen Linda, Keski-Rahkonen Pekka, Saarelainen Taija, Paviala Jenni, Ketola Raimo A, Auriola Seppo, Poutanen Matti, Kostiainen Risto. 2012. Analytica chimica acta. 721: 115-121 A1 Journal article (refereed), original research

Human Placental Perfusions of Anticancer Drug Doxorubicin and Liposomes Encapsulated with Doxorubicin

Repo Jenni, Soininen Suvi K, Meftah Azin, Auriola Seppo, Ruponen Marika, Vähäkangas Kirsi. 2012. Dosis

Intratumor Androgen Biosynthesis in VCaP Xenografts - A model for Castration-Resistant Prostate Cancer

Knuuttila Matias, Yatkin E, Kallio J, Savolainen S, Auriola Seppo, Poutanen M, Mäkelä S. 2012. Dosis

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS

Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Amino acids. 42: 451-460 A1 Journal article (refereed), original research

Transplacental transfer of melamine

Partanen Heidi, Vähäkangas Kirsi, Woo Chit SJ, Auriola Seppo, Veid Jenni, Chen Y, Myllynen Päivi, El Nezami Hani. 2012. Placenta. 33: 60-66 A1 Journal article (refereed), original research

2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites

Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. 2011. Toxicology letters. 207: 34-41 A1 Journal article (refereed), original research

Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion

Veid Jenni, Karttunen Vesa, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. 2011. Toxicology letters. 205: 257-264 A1 Journal article (refereed), original research

Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells

Storvik Markus, Huuskonen Pasi, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku. 2011. Toxicology letters. 202: 161 - 167 A1 Journal article (refereed), original research

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells

Räikkönen Johanna, Taskinen Markku, Dunford James E, Mönkkönen Hannu, Auriola Seppo, Mönkkönen Jukka. 2011. Biochemical and biophysical research communications. 407: 663-667 A1 Journal article (refereed), original research

Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry

Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 879: 677 - 694 A1 Journal article (refereed), original research

Fast and sensitive liquid chromatography-mass spectometry assay for seven androgenic and progestagenic steroids in human serum

Keski-Rahkonen Pekka, Huhtinen Kaisa, Poutanen Matti, Auriola Seppo. 2011. Journal of steroid biochemistry and molecular biology. 127: 396-404 A1 Journal article (refereed), original research

Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices - Enhanced stability and release

Valo Hanna, Kovalainen Miia, Laaksonen Päivi, Häkkinen Merja, Auriola Seppo, Peltonen Leena, Linder Markus, Järvinen Kristiina, Hirvonen Jouni, Laaksonen Timo. 2011. Journal of controlled release. 156: 390-397 A1 Journal article (refereed), original research

Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics

Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Drug metabolism and disposition. 39: 412 - 418 A1 Journal article (refereed), original research

d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry

Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. 2011. Toxicology in vitro. 25: 411 - 425 A1 Journal article (refereed), original research

Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations

Koskela Ali, Anttonen Mikko, Soininen Tuula, Auriola Seppo, Julkunen-Tiitto Riitta, Karjalainen Reijo. 2010.

Assessment of bisphosphonate activity in vitro

Mitrofan LM, Auriola S, Mönkkönen H & Mönkkönen J. 2010. Current pharmaceutical design. 16: 2970-2980 A2 Review article, Literature review, Systematic review

Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells

Stenman SM, Lindfors K, Venäläinen JI, Hautala A, Männistö PT, Garcia-Horsman JA, Kaukovirta-Norja A, Auriola S, Mauriala T, Mäki M et al. 2010. Clinical and experimental immunology. 161: 242-249 A1 Journal article (refereed), original research

Genetic and environmental influence on maize kernel proteome

Anttonen MJ, Lehesranta S, Auriola S, Röhlig RM, Engel K-H & Kärenlampi SO. 2010. Journal of proteome research. 9: 6160-6168 A1 Journal article (refereed), original research

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases

Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Amino acids. 38: 369-381 A1 Journal article (refereed), original research

Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells

Räikkönen J, Mönkkönen H, Auriola S & Mönkkönen J. 2010. Biochemical pharmacology. 79: 777 - 783 A1 Journal article (refereed), original research

Proteomic study of zinc accumulation and tolerance in metal hyperaccumulator plant Thlaspi caerulescens

Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010.

Proteomics of Thlaspi caerulescens accessions and an inter-accession cross segregating for zinc accumulation

Tuomainen M, Tervahauta A, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Häyrinen J, Auriola S, Anttonen M & Kärenlampi S. 2010. Journal of experimental botany. 61: 1075-1087 A1 Journal article (refereed), original research

Proteomics of Thlaspi caerulescens accessions and inter-accession cross segregating for zinc accumulation

Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen K, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010.

Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).

Koskela, A., Anttonen, M., Soininen, T., Saviranta, N., Auriola, S., Julkunen-Tiitto, R. and Karjalainen, R.. 2010. Journal of agricultural and food chemistry. 58: 12289-12295 A1 Journal article (refereed), original research

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

Laine JE, Auriola S, Pasanen M, Juvonen RO. 2009. Xenobiotica. 39: 11-21 A1 Journal article (refereed), original research

Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry

Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. 2009. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 877: 2967-2975 A1 Journal article (refereed), original research

Atmospheric pressure thermospray ionization using a heated microchip nebulizer

Keski-Rahkonen P, Haapala M, Saarela V, Franssila S, Kotiaho T, Kostiainen R, Auriola S. 2009. Rapid communications in mass spectrometry. 23: 3313-3322 A1 Journal article (refereed), original research

Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate

Mannila J, Järvinen K, Holappa J, Matilainen L, Auriola S, Jarho P. 2009. International journal of pharmaceutics. 381: 19-24 A1 Journal article (refereed), original research

Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease

Stenman SM, Venäläinen JI, Lindfors K, Auriola S, Mauriala T, Kaukovirta-Norja A, Jantunen A, Laurila K, Qiao S-W, Sollid LM, Männistö PT, Kaukinen K, Mäki M. 2009. Annals of medicine. 41: 390-400 A1 Journal article (refereed), original research

Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension

Qu C-J, Pöytäkangas T, Jauhiainen M, Auriola S, Lammi MJ. 2009. Cell and tissue research. 337: 103-111 A1 Journal article (refereed), original research

Synthesis of novel deuterium labelled derivates of N-alkylated polyamines

Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Tetrahedron. 65: 547-562 A1 Journal article (refereed), original research

The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder

Matilainen L, Maunu SL, Pajander J, Auriola S, Jääskeläinen I, Lambertsen Larsen K, Järvinen T, Jarho P. 2009. European journal of pharmaceutical sciences. 36: 412-420 A1 Journal article (refereed), original research

Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro

Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J. 2009. British journal of pharmacology. 157: 427-435 A1 Journal article (refereed), original research

Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity

Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Clinical and experimental allergy. 38: 374-381 A1 Journal article (refereed), original research

Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth

Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J. 2008. Anti-cancer drugs. 19: 391-399 A1 Journal article (refereed), original research

Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing

Koponen JM, Happonen AM, Auriola S, Kontkanen H, Buchert J, Poutanen KS, Törrönen R, Koponen JM, Happonen AM, Poutanen KS, Törrönen R. 2008. Journal of agricultural and food chemistry. 56: 3136-3144 A1 Journal article (refereed), original research

Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats

Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH. 2008. Pflugers archiv: european journal of physiology. 456: 369-377 A1 Journal article (refereed), original research

High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone

Pulkkinen M, Palmgrén JJ, Auriola S, Malin M, Seppälä J, Järvinen K. 2008. Rapid communications in mass spectrometry. 22: 121-129 A1 Journal article (refereed), original research

Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines

Jokela TA, Jauhiainen M, Auriola S, Kauhanen M, Tiihonen R, Tammi MI, Tammi RH. 2008. Journal of biological chemistry. 283: 7666-7673 A1 Journal article (refereed), original research

Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes

Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Chemistry and biodiversity. 5: 2431-2441 A1 Journal article (refereed), original research

Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo

Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Xenobiotica. 38: 34-47 A1 Journal article (refereed), original research

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Journal of pharmaceutical and biomedical analysis. 48: 414-421 A1 Journal article (refereed), original research

The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes

Matilainen L, Lambertsen Larsen K, Wimmer R, Keski-Rahkonen P, Auriola S, Järvinen T, Jarho P. 2008. Journal of pharmaceutical sciences. 97: 2720-2729 A1 Journal article (refereed), original research

Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 45: 625-634 A1 Journal article (refereed), original research

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease

Garcia-Horsman JA, Venäläinen JI, Lohi O, Auriola IS, Korponay-Szabo IR, Kaukinen K, Mäki M, Männistö PT. 2007. Scandinavian journal of gastroenterology. 42: 562-571 A1 Journal article (refereed), original research

Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry

Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 43: 606-612 A1 Journal article (refereed), original research

Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes

Qu C-J, Jauhianen M, Auriola S , Helminen Heikki J, Lammi MJ. 2007. Osteoarthritis and cartilage. 15: 773-779 A1 Journal article (refereed), original research

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721 A1 Journal article (refereed), original research

Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry

Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. 2007. Rapid communications in mass spectrometry. 21: 2933-2943 A1 Journal article (refereed), original research

Zoledronic acid-induced IPP/ApppI production in vivo

Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. 2007. Life sciences. 81: 1066-1070 A1 Journal article (refereed), original research

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates

Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. British journal of pharmacology. 147: 437-445 A1 Journal article (refereed), original research

Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions

Palmgrén JJ, Mönkkönen J, Korjamo T, Hassinen A, Auriola S. 2006. European journal of pharmaceutics and biopharmaceutics. 64: 369-378 A1 Journal article (refereed), original research

In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A

Matilainen L, Järvinen K, Toropainen T, Näsi E, Auriola S, Järvinen T, Jarho P. 2006. International journal of pharmaceutics. 318: 41-48 A1 Journal article (refereed), original research

Multivariate analysis of protein profiles of metal hyperaccumulator Thlaspi caerulescens accessions

Tuomainen MH, Nunan N, Lehesranta SJ, Tervahauta AI, Hassinen VH, Schat H, Koistinen KM, Auriola S, McNicol J, Kärenlampi SO. 2006. Proteomics. 6: 3696-3706 A1 Journal article (refereed), original research

Analysis of bean (Phaseolus vulgaris L.) proteins affected by copper stress

Cuypers A, Koistinen KM, Kokko H, Kärenlampi S, Auriola S, Vangronsveld J. 2005. Journal of plant physiology. : 383-392 A1 Journal article (refereed), original research

Comparison of tuber proteomes of potato varieties, landraces, and genetically modified lines

Lehesranta SJ, Davies HV, Shepherd LVT, Nunan N, McNicol JW, Auriola S, Koistinen KM, Suomalainen S, Kokko HI, Kärenlampi SO. 2005. Plant physiology. 138: 1690-1699 A1 Journal article (refereed), original research

Isolation and characterization of yuremamine, a new phytoindole

Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. 2005. Planta medica. 71: 1053-1057 A1 Journal article (refereed), original research

Proteomic analysis of glial fibrillary acidic protein in Alzheimer¿s disease and aging brain

Korolainen MA, Auriola S, Nyman TA, Alafuzoff I, Pirttilä T, Korolainen MA, Pirttilä T. 2005. Neurobiology of disease. 20: 858-870 A1 Journal article (refereed), original research

Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

Palmgrén JJ, Töyräs A, Mauriala T, Mönkkönen J, Auriola S. 2005. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 821: 144-152 A1 Journal article (refereed), original research

Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy

Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Clinical and experimental allergy. 34: 1576-1582 A1 Journal article (refereed), original research

Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC

Palmgrén J, Mönkkönen J, Jukkola E, Niva S, Auriola S. 2004. European journal of pharmaceutics and biopharmaceutics. 57: 319-328 A1 Journal article (refereed), original research

Determination of long-chain fatty acid acyl-coenzyme A compounds using liquid chromatography-electrospray ionization tandem mass spectrometry

Mauriala T, Herzig KH, Heinonen M, Idziak J, Auriola S. 2004. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 808: 263-268 A1 Journal article (refereed), original research

Effects of triaryl phosphates on mouse and human nuclear receptors

Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. 2004. Biochemical pharmacology. 67: 97-106 A1 Journal article (refereed), original research

Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach

Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Neuroscience letters. 367: 235-240 A1 Journal article (refereed), original research

HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis

Mauriala T, Auriola S, Azhayev A, Kayushin A, Korosteleva M, Miroshnikov A. 2004. Journal of pharmaceutical and biomedical analysis. 34: 199-206 A1 Journal article (refereed), original research

Partial amino acid sequence of a cellullase-like component with IgE-binding properties from stachybotrys chartarum

Kärkkäinen M, Raunio P, Rautiainen J, Auriola S, Hinke K, Pasanen A-L. 2004. International archives of allergy and immunology. 133: 136-144 A1 Journal article (refereed), original research

Selective circular oligonucleotide probes improve detection of point mutations in DNA

Tennilä T, Ketomäki K, Penttinen P, Tengvall U, Azhayeva E, Auriola S, Lönnberg H, Azhayev A. 2004. Chemistry and biodiversity. 1: 609-625 A1 Journal article (refereed), original research

The microglia-activating potential of thrombin

Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. Journal of biological chemistry. 279: 51880-51887 A1 Journal article (refereed), original research

Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects

Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. European journal of pharmaceutical sciences. 19: 23-29 A1 Journal article (refereed), original research

Characterization of antisense oligonucleotide-peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography-mass spectrometry

Tengvall U, Auriola S, Antopolsky M, Azhayev A, Biegelman L. 2003. Journal of pharmaceutical and biomedical analysis. 32: 581-590 A1 Journal article (refereed), original research

Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies

Kostiainen R, Kotiaho T, Kuuranne T, Auriola S. 2003. Journal of mass spectrometry. 38: 357-372 A1 Journal article (refereed), original research

Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model

Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106 A1 Journal article (refereed), original research

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats

Niittynen M, Tuomisto JT, Auriola S, Pohjanvirta R, Syrjälä P, Simanainen U, Viluksela M, Tuomisto J. 2002. Toxicological sciences. 71: 112-123 A1 Journal article (refereed), original research

Birch PR-10c is induced by factors causing oxidative stress but appears not to confer tolerance to these agents

Koistinen KM, Hassinen VH, Gynther PAM, Lehesranta SJ, Keinänen SI, Kokko HI, Oksanen EJ, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. New phytologist. 155: 381-391 A1 Journal article (refereed), original research

High-performance liquid chromatography-mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin determination of gamma-carboxyglutamic acid residues

Niiranen H, Budnik BA, Zubarev RA, Auriola S, Lapinjoki S. 2002. Journal of chromatography a. 962: 95-103 A1 Journal article (refereed), original research

Isolation and identification of Aspergillus fumigatus mycotoxins on growth medium and some building materials

Nieminen SM, Kärki R, Auriola S, Toivola M, Laatsch H, Laatikainen R, Hyvärinen A, Von Wright A. 2002. Applied and environmental microbiology. 68: 4871-4875 A1 Journal article (refereed), original research

Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols

Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Journal of chromatography a. 976: 165-170 A1 Journal article (refereed), original research

Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium

El-Nezami HS, Chrevatidis A, Auriola S, Salminen S, Mykkänen H. 2002. Food additives and contaminants. 19: 680-686 A1 Journal article (refereed), original research

Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro

Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 772: 81-87 A1 Journal article (refereed), original research

Stress-related RNase PR-10c is post-translationally modified by glutathione in birch

Koistinen KM, Kokko HI, Hassinen VH, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. Plant cell and environment. 25: 707-715 A1 Journal article (refereed), original research

The cellular uptake and metabolism of clodronate in RAW 264 macrophages

Mönkkönen H, Rogers MJ, Makkonen N, Niva S, Auriola S, Mönkkönen J. 2001. Pharmaceutical research. 18: 1550-1555 A1 Journal article (refereed), original research

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate

Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. 2001. Arthritis and rheumatism. 44: 2201-2210 A1 Journal article (refereed), original research

Two new variants of the lipocalin allergen Bos d 2

Rautiainen J, Auriola S, Konttinen A, Virtanen T, Rytkönen-Nissinen M, Zeiler T, Mäntyjärvi R. 2001. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 763: 91-98 A1 Journal article (refereed), original research

Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry

Mönkkönen H, Moilanen P, Mönkkönen J, Frith JC, Rogers MJ, Auriola S. 2000. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 738: 395-403 A1 Journal article (refereed), original research

Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells

Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Journal of cellular biochemistry. 79: 610-619 A1 Journal article (refereed), original research

Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye

Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. European journal of pharmaceutical sciences. 9: 265-270 A1 Journal article (refereed), original research

Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes

Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. 2000. Archives of toxicology. 74: 511-520 A1 Journal article (refereed), original research

Analysis of adenine nucleotide containing metabolite of clodronate using ion pair HPLC-ESI-MS

Auriola S, Monkkonen H, Frith J, Rogers M, Monkkonen J. Teoksessa: (toim.) , 1999. The 47th ASMS Conference on Mass Spectrometry And Allied Topics. Proceedings. [CD-ROM]. s. . A4 Conference proceedings

Antibioottiset peptidit

Toroskainen C, Auriola S. 1999. Dosis. 15: 12-22 A2 Review article, Literature review, Systematic review

Effects of bisphosphonates on the inflammatory processes of activated macrophages

Mönkkönen J, Makkonen N, Rogers MJ, Frith JC, Auriola S. 1999. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS. 144-146: 321-324 A1 Journal article (refereed), original research

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

Benford HL, Frith JC, Auriola S, Mönkkönen J, Rogers MJ. 1999. Molecular pharmacology. 56: 131-140 A1 Journal article (refereed), original research

High-performance liquid chromatography-mass spectrometry of an osteocalcin derivative

Vähätalo H, Auriola S, Lapinjoki S. 1999. Journal of chromatography a. 846: 49-57 A1 Journal article (refereed), original research

Mass spectrometric (HPLC/ESI-MS/MS) quantification of pyrimido[1,2-a]purin-10(3H)-one, a guanine adduct formed by reaction of malondialdehyde with DNA

Hakala K, Auriola S, Koivisto A, Lönnberg H. 1999. Journal of pharmaceutical and biomedical analysis. 21: 1053-1061 A1 Journal article (refereed), original research

Molecular mechanisms of action of bisphosphonates

Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RGG. 1999. Bone. 24: 73S-79S A1 Journal article (refereed), original research

Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties

Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. 1999. Bioconjugate chemistry. 10: 598-606 A1 Journal article (refereed), original research

Enhancement of sample loadings for the analysis of oligosaccharides isolated from pseudomonas aeruginosa using transient isotachophoresis and capillary zone electrophoresis - electrospray - mass spectrometry

Auriola S, Thibault P, Sadovskaya I, Altman E. 1998. Electrophoresis. 19: 2665-2676 A1 Journal article (refereed), original research

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro

Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 709: 1-10 A1 Journal article (refereed), original research

High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries

Häkkinen S, Auriola S. 1998. Journal of chromatography a. 829: 91-100 A1 Journal article (refereed), original research

Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family

Rautiainen J, Auriola S, Rouvinen J, Kauppinen J, Zeiler T, Novikov D, Virtanen T, Mäntyjärvi RA. 1998. Biochemical and biophysical research communications. 247: 746-750 A1 Journal article (refereed), original research

New building blocks for the preparation of branched oligonucleotides

Azhayev A, Auriola S, Hovinen J. 1998. Nucleosides nucleotides and nucleic acids. 17: 1527-1537 A1 Journal article (refereed), original research

PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula

Utriainen M, Kokko H, Auriola S, Sarrazin O, Kärenlampi S. 1998. Plant cell and environment. 21: 821-828 A1 Journal article (refereed), original research

Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry

Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. Teoksessa: (toim.) , 1997. The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. s. 651. A4 Conference proceedings

Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera

Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. 1997. Investigative ophthalmology and visual science. 38: 627-634 A1 Journal article (refereed), original research

Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach

Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. 1997. Journal of controlled release. 49: 97-104 A1 Journal article (refereed), original research

Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection

Ranta V-P, Urtti A, Auriola S. 1997. Journal of chromatography a. 766: 85-97 A1 Journal article (refereed), original research

Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry

Auriola S, Frith J, Rogers MJ, Koivuniemi A, Mönkkönen J. 1997. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 704: 187-195 A1 Journal article (refereed), original research

Inhibitory properties of double helix forming circular oligonucleotides

Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. 1997. Nucleic acids research. 25: 4954-4961 A1 Journal article (refereed), original research

Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns

Auriola S, Jääskeläinen I, Regina M, Urtti A. 1996. Analytical chemistry. 68: 3907-3911 A1 Journal article (refereed), original research

Determination of urinary 2-mercaptobenzothiazole (2-MBT), the main metabolite of 2-(thiocyanomethylthio)benzothiazole (TCMTB) in humans and rats

Manninen A, Auriola S, Vartiainen M, Liesivuori J, Turunen T, Pasanen M. 1996. Archives of toxicology. 70: 579-584 A1 Journal article (refereed), original research

CE-MS and MS-MS analyses of lipopolysaccharides from p.aeruginosa

Auriola S, Thibault P, Sadovskaya I, Masoud H, Altman E, Richards JC. Teoksessa: (toim.) , 1995. Proceedings the 43rd ASMS Conference on Mass Spectrometry and Allied Topics. s. 977. A4 Conference proceedings

Glucose metabolism in the developing cerebral cortex as detected by 1H {13C} nuclear magnetic resonance spectroscopy ex vivo

Pirttilä T-RM, Auriola SOK, Kauppinen R. 1995. Journal of neurochemistry. 64: 417-423 A1 Journal article (refereed), original research

Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r

Kauppinen RA, Pirttilä T-RM, Auriola SOK, Williams SR. 1994. Biochemical journal. 298: 121-127 A1 Journal article (refereed), original research

Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases

Gibson BW, Medzihradszky D, Hines WM, Auriola S, Kenyon GL. 1994. Journal of the american society for mass spectrometry. 5: 443-451 A1 Journal article (refereed), original research

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Accelerated early childhood growth associates with the development of earlier adrenarche and puberty

Barcode lipids for absolute quantitation of liposomes in ocular tissues

Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis

Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial

Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence

Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study

An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in IVF patients

Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism

Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study

Farmaseuttinen kemia

Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder

In vitro identification of decreased function phenotype ABCG2 variants

Mass spectrometry in ocular drug research

Monoacylglycerol lipase inhibitor JJKK048 ameliorates ABCG2 transporter-mediated regorafenib resistance induced by hypoxia in triple negative breast cancer cells

A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease

Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Pharmacological inhibition of 17ß-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model

Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Caffeine content in newborn hair correlates with maternal dietary intake

Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles

Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up

Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells

L-Type amino acid transporter 1 as a target for drug delivery

Metabolome of canine and human saliva: a non-targeted metabolomics study

Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms

Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery

Side-stream products of malting: a neglected source of phytochemicals

Access and concentrations of atorvastatin in the prostate in men with prostate cancer

Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180

L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Metabolic signature of extracellular vesicles depends on the cell culture conditions

Metabolism of Scoparone in Experimental Animals and Humans

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

Blood steroids are associated with prognosis and fat distribution in endometrial cancer

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure

Diets rich in whole grains increase betainized compounds associated with glucose metabolism

Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage