Seppo Ylä-Herttuala

Nykyiset vastuutehtävät

– Molekulaarisen lääketieteen professori
– Biokeskus Kuopion johtaja
– EU EATRIS-ERIC infrastruktuuriverkoston kansallinen johtaja
– Kansallisen virusvektorilaboratorion johtaja

Tutkimusryhmät

- 1987 FT (Lääketiede), Tampereen yliopisto
- 1982 Lääketieteen lisensiaatti, Tampereen yliopisto
- 1978 Lääketieteen kandidaatti, Tampereen yliopisto
- 2020-2021 Vice Chairman of the ERC Synergy Grant Panel LS7
- 2018-2021 Chairman of Biocenter Finland, University of Helsinki
- 2018-current Board member of the Foundation for Research on Viral Diseases
- 2015-current Associate Editor of Cardiovascular Reserach (Offical Journal of the European Society of Cardiology)
- 2015-2019 Editor-in-Chief of Molecular Therapy (Official Journal of the American Society of Gene and Cell Therapy)
- 2015-2017 Chairman and Board Member, Instrumentarium Science Foundation
- 2014-2016 Chairman, American Society of Gene and Cell Therapy, Cardiovascular Committee
- 2014-2015 Member, American Society of Gene and Cell Therapy, Nominating Committee
- 2012-2013, 2015-2017 Chairman of the ERC consolidated grant panel LS7
- 2011-2017 Chairman and Board Member, Biocenter Oulu, University of Oulu
- 2011-2014 Deputy Member of Board, Institute for Molecular Medicine, University of Helsinki
- 2010-2015 Vice Chairman and Board Member, Instrumentarium Science Foundation
- 2010-2012 Chairman, Biocenter Finland, University of Helsinki
- 2010-2012 President of European Society of Gene and Cell Therapy
- 2008-current Director of Biocenter Kuopio, University of Eastern Finland
- 2005-2020 Academy Professor, Academy of Finland
- 2005-2006 Visiting Professor, Salk Institute, Laboratory of Genetics (Prof. Inder Verma), USA
- 1995- Professor of Molecular Medicine, A.I. Virtanen Institute
- 1992-1995 Senior Research Fellow, Academy of Finland
- 1991-1995 Senior Lecturer in Medical Biochemistry, University of Tampere
- 1991-1992 Junior Research Fellow, Academy of Finland
- 1988-1991 Post-doctoral Fellow, University of California, San Diego, USA (Dr. Daniel Steinberg and Dr. Joseph Witztum)
- 1985-1988 Research Assistant, Academy of Finland
- 1983-1985 Research Associate, University of Tampere

Julkaisut

746 kappaletta

Seppo Ylä-Herttuala

Tutkimusryhmät

Akateemiset tutkinnot

Merkittävät vastuutehtävät

Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-unresponsive Non-muscle-invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial

Lentivirus vector-mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain

Computed tomography coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE-HF 1C)

PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification

Functional roles of the membrane-associated AAV protein MAAP

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

Virusvektorit syövän hoidossa

Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model

Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye

Gene therapy for ischaemic heart disease and heart failure

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart

Long-term safety and efficacy of intramyocardial adenovirusmediated VEGF-DΔNΔC gene therapy eight-year follow-up of phase I KAT301 study

Efficacy and Safety of Clinical Grade hVEGF-D [delta]N[delta]C Gene Therapy Containing Residual Replication-Competent Adenoviruses

Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells

Novel RNAi-Based Therapies for Atherosclerosis

Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer 68Ga-NODAGA-exendin-4

Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death

Finnish Society of Gene and Cell Therapy: A Visionary and Creative Player in the Field

Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations

Arterial Gene Transfer With Lentivirus Vectors: The Jury is Still Out

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial

Management of refractory angina: an update

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia

Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products

Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells

Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea

Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial

Nucleic Acid-Based Therapies for Atherosclerosis

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate

Pahanlaatuisen gliooman hoidon tulevaisuuden näkymiä

Adenoviral gene transfer of Gremlin modulates VEGF-A induced angiogenesis in porcine myocardium

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF

Comparison of efficiency and function of VEGF adenovirus vectors in endothelial cells for gene therapy of placental insufficiency

Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery

Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus

Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models

Development of Large-Scale Downstream Processing for Lentiviral Vectors

Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A 18F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes

Imusuonten merkitys sepelvaltimotaudissa

MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy

DNA methylation processes in atheosclerotic plaque

Serial Optical Coherence Tomography at Baseline, 7 Days, and 1, 3, 6 and 12 Months After Bioresorbable Scaffold Implantation in a Growing Porcine Model

Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

Two Decades of Molecular Therapy: The Journey Continues

Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis

Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference

Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver

Isolation of fresh endothelial cells from porcine heart for cardiovascular studies: a new fast protocol suitable for genomic, transcriptomic and cell biology studies

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function

Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

Preclinical proof-of-concept, analytical development and commercial scale production of lentiviral vector in adherent cells

Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Recent advances in novel therapies for lipid disorders

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Molecular Imaging to Monitor Left Ventricular Remodeling in Heart Failure

ASGCT Annual Meeting 2019