
Seppo Ylä-Herttuala
Professori
LT, FT
Terveystieteiden tiedekunta, A. I. Virtanen -instituutti
seppo.ylaherttuala@uef.fi | 403552075
Nykyiset vastuutehtävät
– Molekulaarisen lääketieteen professori
– Biokeskus Kuopion johtaja
– EU EATRIS-ERIC infrastruktuuriverkoston kansallinen johtaja
– Kansallisen virusvektorilaboratorion johtaja
Tutkimusryhmät
-
- 1987 FT (Lääketiede), Tampereen yliopisto
- 1982 Lääketieteen lisensiaatti, Tampereen yliopisto
- 1978 Lääketieteen kandidaatti, Tampereen yliopisto
-
- 2020-2021 Vice Chairman of the ERC Synergy Grant Panel LS7
- 2018-2021 Chairman of Biocenter Finland, University of Helsinki
- 2018-current Board member of the Foundation for Research on Viral Diseases
- 2015-current Associate Editor of Cardiovascular Reserach (Offical Journal of the European Society of Cardiology)
- 2015-2019 Editor-in-Chief of Molecular Therapy (Official Journal of the American Society of Gene and Cell Therapy)
- 2015-2017 Chairman and Board Member, Instrumentarium Science Foundation
- 2014-2016 Chairman, American Society of Gene and Cell Therapy, Cardiovascular Committee
- 2014-2015 Member, American Society of Gene and Cell Therapy, Nominating Committee
- 2012-2013, 2015-2017 Chairman of the ERC consolidated grant panel LS7
- 2011-2017 Chairman and Board Member, Biocenter Oulu, University of Oulu
- 2011-2014 Deputy Member of Board, Institute for Molecular Medicine, University of Helsinki
- 2010-2015 Vice Chairman and Board Member, Instrumentarium Science Foundation
- 2010-2012 Chairman, Biocenter Finland, University of Helsinki
- 2010-2012 President of European Society of Gene and Cell Therapy
- 2008-current Director of Biocenter Kuopio, University of Eastern Finland
- 2005-2020 Academy Professor, Academy of Finland
- 2005-2006 Visiting Professor, Salk Institute, Laboratory of Genetics (Prof. Inder Verma), USA
- 1995- Professor of Molecular Medicine, A.I. Virtanen Institute
- 1992-1995 Senior Research Fellow, Academy of Finland
- 1991-1995 Senior Lecturer in Medical Biochemistry, University of Tampere
- 1991-1992 Junior Research Fellow, Academy of Finland
- 1988-1991 Post-doctoral Fellow, University of California, San Diego, USA (Dr. Daniel Steinberg and Dr. Joseph Witztum)
- 1985-1988 Research Assistant, Academy of Finland
- 1983-1985 Research Associate, University of Tampere
Julkaisut
746 kappaletta-
Antiadenovirus Antibodies Predict Response Durability to Nadofaragene Firadenovec Therapy in BCG-unresponsive Non-muscle-invasive Bladder Cancer: Secondary Analysis of a Phase 3 Clinical Trial
Mitra, A P; Narayan, V M; Mokkapati, S; Miest, T; Boorjian, S A; Alemozaffar, M; Konety, B R; Shore, N D; Gomella, L G; Kamat, A M; Bivalacqua, T J; Montgomery, J S; Lerner, S P; Busby, J E; Poch, M; Crispen, PL; Steinberg, G D; Schuckman, A K; Downs, T M; Svatek, R S et al. (Incl. Ylä-Herttuala, S; Parker, N). European urology 81 3: 223-228. 2022 -
Lentivirus vector-mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Ahmad, Farizan; Hyvärinen, Anna; Pirinen, Agnieszka; Olsson, Venla; Rummukainen, Jaana; Immonen, Arto; Närväinen, Johanna; Tuunanen, Pasi; Liimatainen, Timo; Kärkkäinen, Virve; Koistinaho, Jari; Ylä-Herttuala, Seppo. Molecular medicine reports 23 6: 422. 2021 -
Computed tomography coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE-HF 1C)
Chow, Benjamin JW; Coyle, Doug; Hossain, Alomgir; Laine, Mika; Hanninen, Helena; Ukkonen, Heikki; Rajda, Miroslav; Larose, Eric Laval; Hartikainen, Juha; Mielniczuk, Lisa; Kass, Malek; Connelly, Kim A; O'Meara, Eileen; Garrard, Linda; Bishop, Helen; Small, Gary; Hedman, Marja; Coyle, Kathryn; Yla-Herttuala, Seppo; Knuuti, Juhani; Wells, George A; Beanlands, Rob S; the IMAGE-HF Investigators. European heart journal : cardiovascular imaging 22 9: 1083-1090. 2021 -
PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification
Feola, Sara; Haapala, Markus; Peltonen, Karita; Capasso, Cristian; Martins, Beatriz; Antignani, Gabriella; Federico, Antonio; Pietiäinen, Vilja; Chiaro, Jacopo; Feodoroff, Michaela; Russo, Salvatore; Rannikko, Antti; Fusciello, Manlio; Koskela, Satu; Partanen, Jukka; Hamdan, Firas; Tähkä, Sari M.; Ylösmäki, Erkko; Greco, Dario; Grönholm, Mikaela et al [incl. Ylä-Herttuala, Seppo]. Acs nano 15 10: 15992-16010. 2021 -
Functional roles of the membrane-associated AAV protein MAAP
Galibert, Lionel; Hyvönen, Amira; Eriksson, Reetta AE; Mattola, Salla; Aho, Vesa; Salminen, Sami; Albers, Justin D; Peltola, Sanna K; Weman, Saija; Nieminen, Tiina; Ylä-Herttuala, Seppo; Lesch, Hanna P; Vihinen-Ranta, Maija; Airenne, Kari J. Scientific reports 11: 21698. 2021 -
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
Gurzeler, Erika; Ruotsalainen, Anna-Kaisa; Laine, Anssi; Valkama, Teemu; Kettunen, Sanna; Laakso, Markku; Ylä-Herttuala, Seppo. PLoS ONE 16 11: e025840. 2021 -
Virusvektorit syövän hoidossa
Hukkanen, Veijo; Ylä-Herttuala, Seppo. Duodecim 137 21: 2261-2269. 2021 -
Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model
Järveläinen, Niko; Halonen, Paavo; Nurro, Jussi; Hätinen, Olli-Pekka; Korpela, Henna; Mäkinen, Petri; Gan, Li-Ming; Fritsche-Danielson, Regina; Ylä-Herttuala, Seppo. Human gene therapy 32 19-20: 1295-1307. 2021 -
Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation
Keränen, Sara; Suutarinen, Santeri; Mallick, Rahul; Laakkonen, Johanna P.; Guo, Diana; Pawlikowska, Ludmila; Jahromi, Behnam Rezai; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; Marchuk, Doug; Krings, Timo; Koivisto, Timo; Lawton, Michael; Radovanovic, Ivan; Kim, Helen; Faughnan, Marie E.; Frösen, Juhana. Acta neurochirurgica 163 9: 2503-2514. 2021 -
Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
Koponen, Sanna; Kokki, Emmi; Kinnunen, Kati; Ylä-Herttuala, Seppo. Pharmaceutics 13 2: 219. 2021 -
Gene therapy for ischaemic heart disease and heart failure
Korpela, H; Järveläinen, N; Siimes, S; Lampela, J; Airaksinen, J; Valli, K; Turunen, M; Pajula, J; Nurro, J; Ylä-Herttuala, S. Journal of internal medicine 290 3: 567-582. 2021 -
Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart
Korpela, Henna; Hätinen, Olli-Pekka; Nieminen, Tiina; Mallick, Rahul; Toivanen, Pyry; Airaksinen, Jonna; Valli, Kaisa; Hakulinen, Mikko; Poutiainen, Pekka; Nurro, Jussi; Ylä-Herttuala, Seppo. iScience 24 12: 103533. 2021 -
Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart
Korpela, Henna; Siimes, Satu; Ylä-Herttuala, Seppo. Journal of visualized experiments 175: e62833. 2021 -
Long-term safety and efficacy of intramyocardial adenovirusmediated VEGF-DΔNΔC gene therapy eight-year follow-up of phase I KAT301 study
Leikas, Aleksi J.; Hassinen, Iiro; Hedman, Antti; Kivelä, Antti; Ylä-Herttuala, Seppo; Hartikainen, Juha E. K.. Gene therapy Published online: 01 October 2021: 1 - 5. 2021 -
Efficacy and Safety of Clinical Grade hVEGF-D [delta]N[delta]C Gene Therapy Containing Residual Replication-Competent Adenoviruses
Leikas, Aleksi Johannes; Laham-Karam, Nihay; Agtereek, Eline; Peltonen, Hanna Marjaana; Selander, Tuomas; Korpisalo, Petra; Holappa, Lari; Hartikainen, Juha EK; Heikura, Tommi; Ylä-Herttuala, Seppo. Human gene therapy 32 13-14: 761-770. 2021 -
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types
Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. Arteriosclerosis, thrombosis, and vascular biology 41 7: 2149-2167. 2021 -
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
Mushimiyimana, I; Niskanen. H; Beter, M; Laakkonen, JP; Kaikkonen, MU; Ylä-Herttuala, S; Laham-Karam, N. Nucleic acids research 49 14: 8078-8096. 2021 -
Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells
Mushimiyimana, Isidore; Tomas Bosch, Vanesa; Niskanen, Henri; Downes, Nicholas; Moreau, Pierre; Hartigan, Kiley; Ylä-Herttuala, Seppo; Laham-Karam, Nihay; Kaikkonen, Minna U.. Molecular and cellular biology 41 7: e00594-20. 2021 -
Novel RNAi-Based Therapies for Atherosclerosis
Ruotsalainen, Anna-Kaisa; Mäkinen, Petri; Ylä-Herttuala, Seppo. Current atherosclerosis reports 23 8: 45. 2021 -
Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer 68Ga-NODAGA-exendin-4
Ståhle, Mia; Hellberg, Sanna; Virta, Jenni; Liljenback, Heidi; Metsälä, Olli; Li, Xiang-Guo; Jauhiainen, Matti; Saukko, Pekka; Ylä-Herttuala, Seppo; Nuutila, Pirjo; Knuuti, Juhani; Saraste, Antti; Roivainen, Anne. American journal of physiology : endocrinology and metabolism 320 5: E989-E998. 2021 -
Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors
Suoranta, Tuisku; Laham-Karam, Nihay; Ylä-Herttuala, Seppo. Human gene therapy 32 19-20: 1270-1279. 2021 -
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. Biomolecules 11 3: 452. 2021 -
Finnish Society of Gene and Cell Therapy: A Visionary and Creative Player in the Field
Tirronen, Annakaisa; Yle-Herttuala, Seppo. Human gene therapy 32 19-20: 986. 2021 -
Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations
Turkki, Vesa; Alppila, Elisa; Ylä-Herttuala, Seppo; Lesch, Hanna P. Viruses 13 5: 939. 2021 -
Arterial Gene Transfer With Lentivirus Vectors: The Jury is Still Out
Ylä-Herttuala, Seppo. Arteriosclerosis thrombosis and vascular biology 41 3: 1156-1157. 2021 -
Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review
Zurek, Michelle; Aavik, Einari; Mallick, Rahul; Ylä-Herttuala, Seppo. Frontiers in genetics 12: 719456. 2021 -
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci
Örd, Tiit; Õunap, Kadri; Stolze, Lindsey; Aherrahrou, Rédouane; Nurminen, Valtteri; Selvarajan, Ilakya; Toropainen, Anu; Lönnberg, Tapio; Aavik, Einari; Yla-Herttuala, Seppo; Civelek, Mete; Romanoski, Casey E; Kaikkonen, Minna U. Circulation research 129 2: 240-258. 2021 -
Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial
Boorjian, Stephen A; Alemozaffar, Mehrdad; Konety, Badrinath R; Shore, Neal D; Gomella, Leonard G; Kamat, Ashish M; Bivalacqua, Trinity J; Montgomery, Jeffrey S; Lerner, Seth P; Busby, Joseph E; Poch, Michael; Crispen, Paul L; Steinberg, Gary D; Schuckman, Anne K; Downs, Tracy M; Svatek, Robert S; Mashni, Joseph; Lane, Brian R; Guzzo, Thomas J; Bratslavsky, Gennady; et al. [incl Ylä-Herttuala, Sep. The Lancet Oncology 2021; 22 1: 107-117. 2020 -
Management of refractory angina: an update
Davies, Allan; Fox, Kim; Galassi, Alfredo R; Banai, Shmuel; Ylä-Herttuala, Seppo; Lüscher, Thomas F. European heart journal 2021; 42 3: 269-283. 2020 -
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, Marie Ac; Prange, Koen Hm; Slenders, Lotte; Örd, Tiit; Elbersen, Danny; Boltjes, Arjan; de Jager, Saskia Ca; Asselbergs, Folkert W; de Borst, Gert J; Aavik, Einari; Lönnberg, Tapio; Lutgens, Esther; Glass, Christopher K; den Ruijter, Hester M; Kaikkonen, Minna U; Bot, Ilze; Slütter, Bram; van der Laan, Sander W; Ylä-Herttuala, Seppo; Mokry, Michal; et al. Circulation research 127 11: 1437-1455. 2020 -
Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia
Laakkonen, Johanna P; Ylä-Herttuala, Seppo / Emerging Technologies for Heart Diseases. Volume 2: Treatments for Myocardial Ischemia and Arrhythmias. 2020. 2020 -
Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products
Gurvich, Olga L; Puttonen, Katja A; Bailey, Aubrey; Kailaanmäki, Anssi; Skirdenko, Vita; Sivonen, Minna; Pietikäinen, Sanna; Parker, Nigel R; Ylä-Herttuala, Seppo; Kekarainen, Tuija. Scientific reports 10 1: 14049. 2020 -
Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells
Hsin-Fu Liu, Oscar; Kiema, Miika; Beter, Mustafa; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Kaikkonen, Minna U. Arteriosclerosis thrombosis and vascular biology 40: 2665-2677. 2020 -
Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination
Husso, Minna; Afara, Isaac O; Nissi, Mikko J; Kuivanen, Antti; Halonen, Paavo; Tarkia, Miikka; Teuho, Jarmo; Saunavaara, Virva; Vainio, Pauli; Sipola, Petri; Manninen, Hannu; Ylä-Herttuala, Seppo; Knuuti, Juhani; Töyräs, Juha. Annals of biomedical engineering 2021; 49: 653-662. 2020 -
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja. Journal of neuroinflammation 17: 194. 2020 -
Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea
Leino, A; Westeren-Punnonen, S; Töyräs, J; Myllymaa, S; Leppänen, T; Ylä-Herttuala, S; Muraja-Murro, A; Kantanen, AM; Autere, J; Jäkälä, P; Mervaala, E; Myllymaa, K. Sleep and breathing 24 4: 1495-1505. 2020 -
Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production
Leinonen, Hanna; Lepola, Saana; Lipponen, Eevi Maria; Heikura, Tommi; Koponen, Tiina; Parker, Nigel R; Ylä-Herttuala, Seppo; Lesch, Hanna. Human gene therapy 31 5-6: 376-384. 2020 -
Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium
Lähteenvuo, Johanna; Hätinen, Olli-Pekka; Kuivanen, Antti; Huusko, Jenni; Paananen, Jussi; Lähteenvuo, Markku; Nurro, Jussi; Hedman, Marja; Hartikainen, Juha; Laham-Karam, Nihay; Mäkinen, Petri; Räsänen, Markus; Alitalo, Kari; Rosenzweig, Anthony; Ylä-Herttuala, Seppo. Molecular therapy 28 7: 1-10. 2020 -
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial
Mathur, A; Fernández-Avilés, F; Bartunek, J; Belmans, A; Crea, F; Dowlut, S; Galiñanes, M; Good, MC; Hartikainen, J; Hauskeller, C; Janssens, S; Kala, P; Kastrup, J; Martin, J; Menasché, P; Sanz-Ruiz, R; Ylä-Herttuala, S; Zeiher, A; On behalf of the BAMI Group [incl. Hytönen, J]. European heart journal 41 38: 3702-3710. 2020 -
Nucleic Acid-Based Therapies for Atherosclerosis
Mäkinen, P; Ruotsalainen, AK; Ylä-Herttuala, S. Current atherosclerosis reports 22 2: 10. 2020 -
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate
Nivajärvi, R; Olsson, V; Hyppönen, V; Bowen, S; Leinonen, HM; Lesch, HP; Ardenkjaer-Larsen, JH; Gröhn, OHJ; Ylä-Herttuala, S; Kettunen, MI. Nmr in biomedicine 33 4: e4250. 2020 -
Pahanlaatuisen gliooman hoidon tulevaisuuden näkymiä
Olsson, Venla; Niittykoski, Minna; Stedt, Hanna; Virsunen, Heli; Ylä-Herttuala, Seppo. Duodecim 136 10: 1242-1248. 2020 -
Adenoviral gene transfer of Gremlin modulates VEGF-A induced angiogenesis in porcine myocardium
Pajula, JJ; Halonen, PJ; Hätinen, OP; Ylä-Herttuala, S; Nurro, J. Human gene therapy 31 3-4: 211-218. 2020 -
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P. Angiogenesis 2021; 24 1: 12-144. 2020 -
Comparison of efficiency and function of VEGF adenovirus vectors in endothelial cells for gene therapy of placental insufficiency
Rossi, Carlo; Lees, Mark; Mehta, Vedanta; Heikura, Tommi; Martin, John F; Zachary, Ian; Spencer, Rebecca; Peebles, Donald; Shaw, Robert; Karhinen, Minna; Ylä-Herttuala, Seppo; David, Anna L. Human gene therapy 31 21-22: 1190-1202. 2020 -
Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery
Saari, H; Turunen, T; Lõhmus, A; Turunen, M; Jalasvuori, M; Butcher, SJ; Ylä-Herttuala, S; Viitala, T; Cerullo, V; Siljander, PRM; Yliperttula, M. Journal of extracellular vesicles 9 1: 1747206. 2020 -
Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus
Schenkwein, Diana; Afzal, Saira; Nousiainen, Alisa; Schmidt, Manfred; Ylä-Herttuala, Seppo. Molecular therapy 28 8: 1-18. 2020 -
Microvessels in Epithelial Ovarian Tumors: High Microvessel Density Is a Significant Feature of Malignant Ovarian Tumors
Sopo, Minna; Anttila, Maarit; Muukkonen, Oona-Tuuli; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Sallinen, Hanna. Anticancer research 40 12: 6923-6931. 2020 -
High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
Sopo, Minna; Sallinen, Hanna; Hämäläinen, Kirsi; Kivelä, Annukka; Ylä-Herttuala, Seppo; Kosma, Veli-Matti; Keski-Nisula, Leea; Anttila, Maarit. PLoS ONE 15 11: e0241484. 2020 -
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice
Ståhle, Miia; Silvola, Johanna MU; Hellberg, Sanna; de Vries, Margreet; Quax, Paul HA; Kroon, Jeffrey; Rinne. Petteri; de Jong, Alwin; Liljenbäck, Heidi; Savisto, Nina; Wickman, Anna; Stroes, Erik SG; Ylä-Herttuala, Seppo; Saukko, Pekka; Abrahamsson, Tommy; Pettersson, Knut; Knuuti, Juhani; Roivainen, Anne; Saraste, Antti. JACC : Basic to translational science 5 4: 360-373. 2020 -
Evaluation of Biodegradable Stent Graft Coatings in Pig and Rabbit Models
Taavitsainen, J; Tarvainen, S; Kuivanen, A; Mangiardi, EK; Guelcher, M; Martin, J; Mathur, A; Hytönen, JP; Ylä-Herttuala, S. Journal of vascular research 57: 65-75. 2020 -
Development of Large-Scale Downstream Processing for Lentiviral Vectors
Valkama, Anniina J; Oruetxebarria, Igor; Lipponen, Eevi M; Leinonen, Hanna M; Käyhty, Piia; Hynynen, Heidi; Turkki, Vesa; Malinen, Joonas; Miinalainen, Tuukka; Heikura, Tommi; Parker, Nigel R; Ylä-Herttuala, Seppo; Lesch, Hanna P. Molecular therapy. Methods & clinical development 17: 717-730. 2020 -
Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A 18F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes
Virta, Jenni; Hellberg, Sanna; Liljenbäcka, Heidi; Ståhle, Mia; Silvola, Johanna MU; Huusko, Jenni; Söderström, Mirva; Knuuti, Juhani; Nuutila, Pirjo; Ylä-Herttuala, Seppo; Gomezi, Maria F; Roivainen, Anne; Saraste, Antti. Atherosclerosis 305: 64-72. 2020 -
Imusuonten merkitys sepelvaltimotaudissa
Vuorio, Taina; Ylä-Herttuala, Seppo. Duodecim 136 11: 1326-1332. 2020 -
MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy
Yang, Ying; Liu, Yan; Li, Yiping; Chen, Zhongli; Xiong, Yixin; Zhou, Taicheng; Tao, Wenyu; Xu, Fan; Yang, Hanling; Ylä-Herttuala, Seppo; Chaurasia, Shyam S; Whaley-Connell, Adam; Yang, Ke. Journal of clinical endocrinology and metabolism 105 11: dgaa538. 2020 -
DNA methylation processes in atheosclerotic plaque
Aavik, Einari; Babu, Mohan; Ylä-Herttuala, Seppo. Atherosclerosis 281: 168-179. 2019 -
Serial Optical Coherence Tomography at Baseline, 7 Days, and 1, 3, 6 and 12 Months After Bioresorbable Scaffold Implantation in a Growing Porcine Model
Asano, T; Hytönen, J; Chichareon, P; Taavitsainen, J; Kogame, N; Katagiri, Y; Miyazaki, Y; Takahashi, K; Modolo, R; Komiyama, H; Tenekecioglu, E; Sotomi, Y; Wykrzykowska, JJ; Piek, JJ; Martin, J; Baumbach, A; Mathur, A; Onuma, Y; Ylä-Herttuala, S; Serruys, PW. Circulation journal 83 3: 556-566. 2019 -
Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques
Banerjee, Shubhadeep; Sengupta, Jayeeta; Aljarilla, Ana; Setaro, Francesca; Mäkinen, Petri I; Wu, LinPing; Holappa, Lari; de la Escosura, Andres; Martinelli, Chiara; Trohopoulos, Panagiotis N; Ylä-Herttuala, Seppo; Urbanics, Rudolf; Szebeni, Janos; Torres, Tomas; Krol, Silke. Precision Nanomedicine 2 2: 278-302. 2019 -
Two Decades of Molecular Therapy: The Journey Continues
Frederickson, Robert M; Ylä-Herttuala, Seppo. Molecular therapy 27 1: 1-2. 2019 -
Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction
Grönman, M; Tarkia, M; Stark, C; Vähäsilta, T; Kiviniemi, T; Lubberink, M; Halonen, P; Kuivanen, A; Saunavaara, V; Tolvanen, T; Teuho, J; Teräs, M; Savunen, T; Pietilä, M; Ylä-Herttuala, S; Roivainen, A; Knuuti, J; Saraste, A. Journal of nuclear cardiology [First Online: 17 July 2019]: 1-10. 2019 -
Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques
Hellberg, S; Silvola, JMU; Liljenbäck, H; Kiugel, M; Eskola, O; Hakovirta, H; Hörkkö, S; Morisson-Iveson, V; Hirani, E; Saukko, P; Ylä-Herttuala, S; Knuuti, J; Saraste, A; Roivainen, A. Molecules 24 6: 1072. 2019 -
Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis
Hokkanen, K; Tirronen, A; Ylä-Herttuala, S. Current opinion in lipidology 30 5: 370-376. 2019 -
Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference
Husso, M; Nissi, MJ; Kuivanen, A; Halonen, P; Tarkia, M; Teuho, J; Saunavaara, V; Vainio, P; Sipola, P; Manninen, H; Ylä-Herttuala, S; Knuuti, J; Töyräs, J. Bmc medical imaging 19 1: 58. 2019 -
Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver
Hytönen, E; Laurema, A; Kankkonen, H; Miyanohara, A; Kärjä, V; Hujo, M; Laham-Karam, N; Ylä-Herttuala, S. Scientific reports 9 1: 6934. 2019 -
Isolation of fresh endothelial cells from porcine heart for cardiovascular studies: a new fast protocol suitable for genomic, transcriptomic and cell biology studies
Hätinen, OA; Lähteenvuo, JE; Korpela, HJ; Pajula, JJ; Ylä-Herttuala, S. BMC Molecular and Cell Biology 20: 32. 2019 -
Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
Jauhiainen, Suvi; Laakkonen, Johanna P; Ketola, Kirsi; Toivanen, Pyry, I; Nieminen, Tina; Ninchoji, Takeshi; Levonen, Anna-Liisa; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. Frontiers in physiology 10: 224. 2019 -
Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta
Laakkonen, Johanna P; Lähteenvuo, Johanna; Jauhiainen, Suvi; Heikura, Tommi; Ylä-Herttuala, Seppo. Vascular pharmacology 112: 91-101. 2019 -
Preclinical proof-of-concept, analytical development and commercial scale production of lentiviral vector in adherent cells
Leinonen, HM; Lipponen, EM; Valkama, AJ; Hynynen, H; Oruetxebarria, I; Turkki, V; Olsson, V; Kurkipuro, J; Samaranayake, H; Määttä, A-M; Parker, NR; Ylä-Herttuala, S; Lesch, HP. Molecular therapy. Methods & clinical development 15: 63-71. 2019 -
Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation
Plote, Devin; Choi, Woonyoung; Mokkapati, Sharada; Sundi, Debasish; Ferguson, James E, III; Duplisea, Jon; Parker, Nigel R; Ylä-Herttuala, Seppo; McConkey, David; Schluns, Kimberly S; Dinney, Colin P. Oncoimmunology 8 5: e1577125. 2019 -
Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma
Sallinen, H; Janhonen, S; Pölönen, P; Niskanen, H; Liu, OH; Kivelä, A; Hartikainen, JM; Anttila, M; Heinäniemi, M; Ylä-Herttuala, S; Kaikkonen, MU. Bmc cancer 19: 1121. 2019 -
Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers
Setaro, Francesca; Wennink, Jos W H; Mäkinen, Petri I; Holappa, Lari; Trohopoulus, Panagiotis N; Ylä-Herttuala, Seppo; van Nostrum, Cornelus F; De la Escosura, Andres; Torres, Tomás. Journal of materials chemistry. b 2020; 8 2: 282-289. 2019 -
Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
Sopo, M; Anttila, M; Hämäläinen, K; Kivelä, A; Ylä-Herttuala, S; Kosma, VM; Keski-Nisula, L; Sallinen, H. Bmc cancer 19: 584. 2019 -
Recent advances in novel therapies for lipid disorders
Tirronen, Annakaisa; Hokkanen, Krista; Vuorio, Taina; Ylä-Herttuala, Seppo. Human molecular genetics 28 R1: R49-R54. 2019 -
Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress
Turunen, TA; Roberts, TC; Laitinen, P; Väänänen, MA; Korhonen, P; Malm, T; Ylä-Herttuala, S; Turunen, M. Scientific reports 9: 10332. 2019 -
Molecular Imaging to Monitor Left Ventricular Remodeling in Heart Failure
Ylä-Herttuala, Elias; Saraste, Antti; Knuuti, Juhani; Liimatainen, Timo; Ylä-Herttuala, Seppo. Current cardiovascular imaging reports 12 4: 11. 2019 -
ASGCT Annual Meeting 2019
Ylä-Herttuala, Seppo. Molecular therapy 27 8: 1339. 2019 -
Gene and Cell Therapy: Success Stories and Future Challenges
Ylä-Herttuala, Seppo. Molecular therapy 27 5: 891-892. 2019 -
Gene Therapy of Critical Limb Ischemia Enters Clinical Use
Ylä-Herttuala, Seppo. Molecular therapy 27 12: 2053. 2019 -
Editorial: Vascularization for Regenerative Medicine
Banfi, Andrea; Holnthoner, Wolfgang; Martino, Mikael M; Ylä-Herttuala, Seppo. Frontiers in bioengineering and biotechnology 6: 175. 2018 -
Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules
Belt, H; Koponen, JK; Kekarainen, T; Puttonen, KA; Mäkinen, PI; Niskanen, H;, Oja, J; Wirth, G; Koistinaho, J; Kaikkonen, MU; Ylä-Herttuala, S. Frontiers in cardiovascular medicine 5: 16. 2018 -
In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR-/-ApoB100/100 mice
Blanco, F; Heinonen, SE; Gurzeler, E; Berglund, LM; Dutius Andersson, AM; Kotova, O; Jönsson-Rylander, AC; Ylä-Herttuala, S; Gomez, MF. DIABETES AND VASCULAR DISEASE RESEARCH 15 4: 302-313. 2018 -
Consensus Statement of European Societies of Gene and Cell Therapy on the Reported Birth of Genome-Edited Babies in China
Büning, Hildegard; Griesenbach, Uta; Fehse, Boris; Ylä-Herttuala, Seppo; Anagnou, Nicholas P; van Beusechem, Victor; Raya, Angel; Verhoeyen, Els. Human gene therapy 29 12: 1337-1338. 2018 -
Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working group on Atherosclerosis and Vascular Biology
Caporali, A; Bäck, M; Daemen, MJ; Hoefer, IE; Jones, EA; Lutgens, E; Matter, CM; Bochaton-Piallat, ML; Siekmann, AF; Sluimer, JC; Steffens, S; Tuñón, J; Vindis, C; Wentzel, JJ; Ylä-Herttuala, S; Evans, PC. Cardiovascular research 114 11: 1411-1421. 2018 -
Differential but Complementary HIF1[alfa] and HIF2[alfa] Transcriptional Regulation
Downes, Nicholas L; Laham-Karam, Nihay; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. MOLECULAR THERAPY 26 7: 1735-1745. 2018 -
The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside
Duplisea, Jonathan J; Mokkapati, Sharada; Plote, Devin; Schluns, Kimberley S; McConkey, David J; Yla-Herttuala, Seppo; Parker, Nigel R; Dinney, Colin P. World journal of urology 2019; 37 10: 2041-2049. 2018 -
EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF
Groppa, E; Brkic, S; Uccelli, A; Wirth, G; Korpisalo-Pirinen, P; Filippova, M; Dasen. B; Sacchi, V; Muraro, MG; Trani, M; Reginato, S; Gianni-Barrera, R; Ylä-Herttuala, S; Banfi, A. EMBO REPORTS 19 4: e45054. 2018 -
Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
Gurzeler, Erika; Aavik, Einari; Laine, Anssi; Valkama, Teemu; Niskanen, Henri; Huusko, Jenni; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. Biochimica et biophysica acta: general subjects 2019; 1863 2: 481-490. 2018 -
Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with 18F-GE-180, a Radiotracer for Translocator Protein (TSPO)
Hellberg, Sanna; Liljenbäck, Heidi; Eskola, Olli; Morisson-Iveson, Veronique; Morrison, Matthew; Trigg, William; Saukko, Pekka; Ylä-Herttuala, Seppo; Knuuti, Juhani; Saraste, Antti; Roivainen, Anne. Contrast Media and Molecular Imaging 2018: 9186902. 2018 -
Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis
Huang, Jun; Kelly, Ciaran P; Bakirtzi, Kyriaki; Villafuerte Gálvez, Javier A; Lyras, Dena; Mileto, Steven J; Larcombe, Sarah; Xu, Hua; Yang, Xiaotong; Shields, Kelsey S; Zhu, Weishu; Zhang, Yi; Goldsmith, Jeffrey D; Patel, Ishan J; Hansen, Joshua; Huang, Meijin; Yla-Herttuala, Seppo; Moss, Alan C; Paredes-Sabja, Daniel; Pothoulakis, Charalabos; et al.. Nature microbiology 2019; 4 2: 269-279. 2018 -
Kardiologian tutkimustoiminta Suomessa viimeisten 10 vuoden aikana
Huikuri, Heikki; Hartikainen, Juha; Ylä-Herttuala, Seppo; Sinisalo, Juha; Airaksinen, Juhani; Nikus, Kjell. Sydänääni: Suomen kardiologisen seuran lehti 29 1A: 207-211. 2018 -
Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits
Hytönen, Jarkko P; Taavitsainen, Jouni; Laitinen, Johannes T T; Partanen, Anna; Alitalo, Kari; Leppänen, Olli; Ylä-Herttuala, Seppo. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 121: 145-154. 2018 -
Biodegradable coronary scaffolds - their future and clinical and technological challenges
Hytönen, Jarkko P; Taavitsainen, Jouni; Tarvainen, Santeri; Ylä-Herttuala, Seppo. CARDIOVASCULAR RESEARCH 114 8: 1063-1072. 2018 -
Human Vascular Endothelial Growth Factor A165 Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration
Kokki, Emmi; Karttunen, Tommi; Olsson, Venla; Kinnunen, Kati; Ylä-Herttuala, Seppo. Genes 9 9: E438. 2018 -
Syövän immunologinen täsmähoito geneettisesti muokatuilla T-soluilla
Korhonen, Matti; Keränen, Mikko; Vettenranta, Kim; Leppä, Sirpa; Ylä-Herttuala, Seppo; Porkka, Kimmo. Duodecim 134 16: 1592-1599. 2018 -
Exosomes as secondary inductive signals involved in kidney organogenesis
Krause, M; Rak-Raszewska, A; Naillat, F; Saarela, U; Schmidt, C; Ronkainen, VP; Bart, G; Ylä-Herttuala, S; Vainio, SJ. Journal of Extracellular Vesicles 7 1: 1422675. 2018 -
T-2, T-1rho and T-RAFF4 detect early regenerative changes in mouse ischemic skeletal muscle
Laakso, Hanne; Wirth, Galina; Korpisalo, Petra; Ylä-Herttuala, Elias; Michaeli, Shalom; Ylä-Herttuala, Seppo; Liimatainen, Timo. Nmr in biomedicine 31 5: e3909. 2018 -
Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
Merentie, Mari; Rissanen, Riina; Lottonen-Raikaslehto, Line; Huusko, Jenni; Gurzeler, Erika; Turunen, Mikko P; Holappa, Lari; Mäkinen, Petri; Ylä-Herttuala, Seppo. PLOS ONE 13 1: e0190981. 2018 -
Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells
Moreau, Pierre R; Örd, Tiit; Downes, Nicholas L; Niskanen, Henri; Bouvy-Liivrand, Maria; Aavik, Einari; Ylä-Herttuala, Seppo; Kaikkonen, Minna U. Frontiers in cardiovascular medicine 5 159: 12. 2018 -
Long Non-Coding RNA Modulation of VEGF-A during Hypoxia
Nieminen, Tiina; Scott, Tristan A; Lin, Feng-Mao; Chen, Zhen; Yla-Herttuala, Seppo; Morris, Kevin V. Non-Coding RNA 4 4: 34. 2018 -
Verisuonten seinämien somaattiset mutaatiot aivojen valtimo-laskimoepämuodostumien aiheuttajina
Nikolaev, Sergey I; Vetiska, Sandra; Bonilla, Ximena; Boudreau, Emilie; Jauhiainen, Suvi; Jahromi, Behnam Rezai; Khyzha, Nadiya; DiStefano, Peter V; Suutarinen, Santeri; Kiehl, Tim-Rasmus; Pereira, Vitor Mendes; Herman, Alexander M; Krings, Timo; Andrade-Barazarte, Hugo; Tung, Takyee; Valiante, Taufik; Zadeh, Gelareh; Tymianski, Mike; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; et al.. Duodecim 134 3: 298. 2018 -
Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
Nikolaev, SI; Vetiska, S; Bonilla, X; Boudreau, E; Jauhiainen, S; Rezai, Jahromi B; Khyzha, N; DiStefano, PV; Suutarinen, S; Kiehl, TR; Mendes Pereira, V; Herman, AM; Krings, T; Andrade-Barazarte, H; Tung, T; Valiante, T; Zadeh, G; Tymianski, M; Rauramaa, T; Ylä-Herttuala, S et al.. NEW ENGLAND JOURNAL OF MEDICINE 378 3: 250-261. 2018 -
Consensus guidelines for the use and interpretation of angiogenesis assays
Nowak-Sliwinska, P; Alitalo, K; Allen, E; Anisimov, A; Aplin, AC; Auerbach, R; Augustin, HG; Bates, DO; van Beijnum, JR; Bender, RHF; Bergers, G; Bikfalvi, A; Bischoff, J; Böck, BC; Brooks, PC; Bussolino, F; Cakir, B; Carmeliet, P; Castranova, D; Cimpean, AM; et al. [Incl Yläherttuala, Seppo; Nurro, Jussi]. Angiogenesis 21 3: 425-532. 2018 -
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
Que, X; Hung, MY; Yeang, C; Gonen, A; Prohaska, TA; Sun, X; Diehl, C; Määttä, A; Gaddis, DE; Bowden, K; Pattison, J; MacDonald, JG; Ylä-Herttuala, S; Mellon, PL; Hedrick, CC; Ley, K; Miller, YI; Glass, CK; Peterson, KL; Binder, CJ; et al.. Nature 558: 301-306. 2018 -
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolemic mice
Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P; Heiskanen, Emmi; Merentie, Mari; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa. CARDIOVASCULAR RESEARCH 2019; 115 1: 243-254. 2018 -
Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths
Ruuth, M; Nguyen, SD; Vihervaara, T; Hilvo, M; Laajala, TD; Kondadi, PK; Gisterå, A; Lähteenmäki, H; Kittilä, T; Huusko, J; Uusitupa, M; Schwab, U; Savolainen, MJ; Sinisalo, J; Lokki, ML; Nieminen, MS; Jula, A; Perola, M; Ylä-Herttula, S; Rudel, L; et al.. EUROPEAN HEART JOURNAL 39 27: 2562-2573. 2018 -
Up-regulation of Mismatch Repair Pathway by Suicide Gene Therapy: Implications on the use of Temozolomide Treatment in Malignant Glioma
Samaranayake, Haritha Dhammika; Olsson, Venla; Kurkipuro, Jere Tuomas; Määttä, Ann-Marie; Stedt, Hanna; Kärkkäinen, Hanna-Riikka; Kaikkonen, Minna U; Taavitsainen, Miia; Vuorio, Taina; Parker, Nigel; Ylä-Herttuala, Seppo. Journal of Cancer Science & Therapy 10 8: 214-222. 2018 -
Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats
Schenkwein, Diana; Ylä-Herttuala, Seppo. Molecular therapy 26 3: 659-660. 2018 -
Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions
Siemelink, Marten A; van der Laan, Sander W; Haitjema, Saskia; van Koeverden, Ian D; Schaap, Jacco; Wesseling, Marian; de Jager, Saskia C A; Mokry, Michal; van Iterson, Maarten; Dekkers, Koen F; Luijk, Rene; Asl, Hassan Foroughi; Michoel, Tom; Björkegren, Johan L M; Aavik, Einari; Ylä-Herttuala, Seppo; de Borst, Gert J; Asselbergs, Folkert W; el Azzouzi, Hamid; den Ruijter, Hester M; et al.. Circulation. Genomic and precision medicine 11 9: e002030. 2018 -
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
Silvola, JMU; Li, XG; Virta, J; Marjamäki, P; Liljenbäck, H; Hytönen, JP; Tarkia, M; Saunavaara, V; Hurme, S; Palani, S; Hakovirta, H; Ylä-Herttuala, S; Saukko, P; Chen, Q; Low, PS; Knuuti, J; Saraste, A; Roivainen, A. Scientific Reports 8 1: 9720. 2018 -
Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants
Tirronen, Annakaisa; Vuorio, Taina; Kettunen, Sanna; Hokkanen, Krista; Ramms, Bastian; Niskanen, Henri; Laakso, Hanne; Kaikkonen, Minna U; Jauhiainen, Matti; Gordts, Philip LSM; Ylä-Herttuala, Seppo. Arteriosclerosis thrombosis and vascular biology 38 10: 2327-2337. 2018 -
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
van Zuydam, Natalie R; Ahlqvist, Emma; Sandholm, Niina; Deshmukh, Harshal; Rayner N, William; bdalla, Moustafa; Ladenvall, Claes; Ziemek, Daniel; Fauman, Eric; Robertson, Neil R; McKeigue, Paul M; Valo, Erkka; Forsblom, Carol; Harjutsalo, Valma; Perna, Annalisa; Rurali, Erica; Marcovecchio M, Loredana; Igo, Robert P Jr; Summit Consortium; et al. (incl. Ylä-Herttuala, S; Laakso, M). Diabetes 67 7: 1414-1427. 2018 -
Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
Vuorio, Taina; Ylä-Herttuala, Elias; Laakkonen, Johanna P; Laidinen, Svetlana; Liimatainen, Timo; Ylä-Herttuala, Seppo. Scientific Reports 8: 16709. 2018 -
All Eyes and Ears for Gene Therapy
Ylä-Herttuala, Seppo. Molecular therapy 26 8: 1867. 2018 -
CRISPR/Cas9 and p53: An Odd Couple Requiring Relationship Management
Ylä-Herttuala, Seppo. MOLECULAR THERAPY 26 12: 2711. 2018 -
iPSC-Derived Cardiomyocytes Taken to Rescue Infarcted Heart Muscle in Coronary Heart Disease Patients
Ylä-Herttuala, Seppo. MOLECULAR THERAPY 26 9: 2077. 2018 -
Uusi geenihoito tulossa uusiutuneen hoitoresistentin akuutin lymfoblastileukemian hoitoon
Ylä-Herttuala, Seppo. Duodecim 134 2: 104-105. 2018 -
Highlighting the Field of Cardiovascular Regenerative Medicine
Zimmermann, Wolfram-Hubertus; Yla-Herttuala, Seppo; Hajjar, Roger J. MOLECULAR THERAPY 26 7: 1595. 2018 -
Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation
Durga Devi T, Babu M, Mäkinen P, Kaikkonen M, Heinaniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N,Tavi P, Ylä-Herttuala S. AMERICAN JOURNAL OF PATHOLOGY 187 12: 2659-2673. 2017 -
Effects of linagliptin intervention on atherosclerotic plaque inflammation and 18F-FDG uptake in a mouse model of type 2 diabetes
Virta J, Silvola J, Hellberg S, Ståhle M, Liljenbäck H, Ylä-Herttuala S, Huusko J, Nuutila P, Knuuti J, Roivainen A, Saraste A. Atherosclerosis. 2017. 2017 -
Global position paper on cardiovascular regenerative medicine
Fernández-Avilés Francisco, Sanz-Ruiz Ricardo, Climent Andreu M, Badimon Lina, Bolli Roberto, Charron Dominique, Fuster Valentin, Janssens Stefan, Kastrup Jens, Kim Hyo-Soo, Lüscher Thomas F, Martin John F, Menasché Philippe, Simari Robert D, Stone Gregg W, Terzic Andre, Willerson James T, Wu Joseph C, Broughton Kathleen, DiFede Darcy L et al incl. Ylä-Herttuala Seppo. EUROPEAN HEART JOURNAL 38 33: 2532-2546. 2017 -
Imaging of [alpha]vß3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography
Grönman M, Tarkia M, Kiviniemi T, Halonen P, Kuivanen A, Savunen T, Tolvanen T, Teuho J, Käkelä M, Metsälä O, Pietilä M, Saukko P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. Journal of Translational Medicine 15: 144. 2017 -
Adenoviral intramyocardial VEGF-DdeltaNdeltaC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
Hartikainen J, Hassinen I, Hedman A, Kivelä A, Saraste A, Knuuti J, Husso M, Mussalo H, Hedman M, Rissanen TT, Toivanen P, Heikura T, Witztum JL, Tsimikas S, Ylä-Herttuala S. EUROPEAN HEART JOURNAL 38 33: 2547-2555. 2017 -
Lupaavia tuloksia sepelvaltimotaudin geenihoidosta
Hartikainen Juha, Hassinen Iiro, Hedman Antti, Kivelä Antti, Saraste Antti, Knuuti Juhani, Husso Minna, Mussalo Hanna, Hedman Marja, Rissanen Tuomas T, Toivanen Pyry, Heikura Tommi, Witztum Joseph, Tsimikas Sotirios, Ylä-Herttuala Seppo. DUODECIM 133 17: 1613. 2017 -
Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100/100 mice
Hellberg S, Sippola S, Liljenbäck H, Virta J, Silvola JMU, Ståhle M, Savisto N, Metso J, Jauhiainen M, Saukko P, Ylä-Herttuala S, Nuutila P, Knuuti J, Roivainen A, Saraste A. ATHEROSCLEROSIS 263: 369-376. 2017 -
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion
Kaartinen T, Luostarinen A, Maliniemi P, Keto J, Arvas M, Belt H, Koponen J, Loskog A, Mustjoki S, Porkka K, Ylä-Herttuala S, Korhonen M. Cytotherapy 19 6: 689-702. 2017 -
Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction
Kaikkonen Minna U, Halonen Paavo, Liu Oscar Hsin-Fu, Turunen Tiia A, Pajula Juho, Moreau Pierre, Selvarajan Ilakya, Tuomainen Tomi, Aavik Einari, Tavi Pasi, Ylä-Herttuala Seppo. Circulation: Cardiovascular Genetics 10 3: e001702. 2017 -
Comparative Study of Adeno-associated Virus, Adenovirus, Baculovirus and Lentivirus Vectors for Gene Therapy of the Eyes
Kalesnykas G, Kokki E, Alasaarela L, Lesch HP, Tuulos T, Kinnunen K, Uusitalo H, Airenne K, Ylä-Herttuala S. CURRENT GENE THERAPY 17 3: 235-247. 2017 -
The follow-up of progressive hypertrophic cardiomyopathy using magnetic resonance rotating frame relaxation times
Khan, Muhammad Arsalan; Laakso, Hanne; Laidinen, Svetlana; Kettunen, Sanna; Heikura, Tommi; Ylä-Herttuala, Seppo; Liimatainen, Timo. NMR IN BIOMEDICINE 2018; 31 2: e3871. 2017 -
High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy
Kivelä AM, Huusko J, Gurzeler E, Laine A, Dijkstra MH, Dragneva G, Andersen CB, Moestrup SK, Ylä-Herttuala S. Scientific Reports 7 386: 1-8. 2017 -
Activating the Chromatin by Noncoding RNAs
Laham-Karam, Nihay; Laitinen, Pia; Turunen, Tiia A; Ylä-Herttuala, Seppo. ANTIOXIDANTS AND REDOX SIGNALING 2018; 29 9: 813-831. 2017 -
Magnetically Coated Bioabsorbable Stents for Renormalization of Arterial Vessel Walls after Stent Implantation
Lee, JS; Han, P; Song, E; Kim, D; Lee, H; Labowsky, M; Taavitsainen, J; Ylä-Herttuala, S; Hytönen, J; Gülcher, M; Perampaladas, K; Sinusas, AJ; Martin, J; Mathur, A; Fahmy, TM. NANOLETTERS 2018; 18 1: 272-281. 2017 -
Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI
Lindgren A, Anttila M, Rautiainen S, Arponen O, Kivelä A, Mäkinen P, Härmä K, Hämäläinen K, Kosma V-M, Ylä-Herttuala S, Vanninen R, Sallinen H. EUROPEAN RADIOLOGY 27 9: 4002-4012. 2017 -
Left ventricular remodeling leads to heart failure in mice with cardiac-specific overexpression of VEGF-B167: echocardiography and magnetic resonance imaging study
Lottonen-Raikaslehto L, Rissanen R, Gurzeler E, Merentie M, Huusko J, Schneider JE, Liimatainen T, Ylä-Herttuala S. Physiological Reports 5 6: e13096. 2017 -
Advances and Challenges in Cardiovascular Gene Therapy
Lähteenvuo Johanna, Ylä-Herttuala Seppo. HUMAN GENE THERAPY 28 11: 1024-1032. 2017 -
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: rationale and design of the BAMI trial
Mathur A, Arnold R, Assmus B, Bartunek J, Belmans A, Bönig H, Crea F, Dimmeler S, Dowlut S, Fernández-Avilés F, Galiñanes M, Garcia-Dorado D, Hartikainen J, Hill J, Hogardt-Noll A, Homsy C, Janssens S, Kala P, Kastrup J, Martin J et al.. EUROPEAN JOURNAL OF HEART FAILURE 19 11: 1545-1550. 2017 -
The consensus of the Task Force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for the treatment of acute myocardial infarction and heart failure: update 2016
Mathur A, Fernández-Avilés F, Dimmeler S, Hauskeller C, Janssens S, Menasche P, Wojakowski W, Martin JF, Zeiher A, the BAMI Investigators. EUROPEAN HEART JOURNAL 38 39: 2930-2935. 2017 -
Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P. Frontiers in Physiology 8: 373. 2017 -
Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas
Niittykoski Minna, von und zu Fraunberg Mikael, Martikainen Miika, Rauramaa, Immonen Arto, Koponen Susanna, Leinonen Ville, Vähä-Koskela Markus, Zhang Qiwei, Kühnel Florian, Mei Ya-Fang, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Hinkkanen Ari. Translational Oncology 10 5: 772-779. 2017 -
Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions
Niskanen, Henri; Tuszynska, Irina; Zaborowski, Rafal; Heinäniemi, Merja; Ylä-Herttuala, Seppo; Wilczynski, Bartek; Kaikkonen, Minna U. NUCLEIC ACIDS RESEARCH 2018; 46 4: 1724-1740. 2017 -
Positron emission tomography tracer [68GA]NODAGA-EXENDIN-4 detects glucagon-like peptide-1 receptor expression in mouse atherosclerotic vascular lesions
Ståhle M, Hellberg S, Virta J, Liljenbäck H, Metsälä O, Jauhiainen M, Saukko P, Ylä-Herttuala S, Nuutila P, Knuuti J, Saraste A, Roivainen A. Atherosclerosis. 2017. 2017 -
Intravesical rAd-IFN[alfa]/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study
Shore ND, Boorjian SA, Canter DJ, Ogan K, Karsh LI, Downs TM, Gomella LG, Kamat AM, Lotan Y, Svatek RS, Bivalacqua TJ, Grubb RL, Krupski TL, Lerner SP, Woods ME, Inman BA, Milowsky MI, Boyd A, Treasure FP, Gregory G et al. JOURNAL OF CLINICAL ONCOLOGY 35 30: 3410-3416. 2017 -
Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling
Toivanen Pyry I, Nieminen Tiina, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Ylä-Herttuala Seppo. Scientific Reports 7: 5525. 2017 -
Combined gene therapy using AdsVEGFR2 and AdsTie2 with chemotherapy reduces the growth of human ovarian cancer and formation of ascites in mice
Tuppurainen L, Sallinen H, Karvonen A, Valkonen E, Laakso H, Liimatainen T, Hytönen E, Hämäläinen K, Kosma V-M, Anttila M, Ylä-Herttuala S. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 27 5: 879-886. 2017 -
Epigenomics
Turunen TA, Väänänen M-A, Ylä-Herttuala S. Teoksessa: Sawyer Douglas, Vasan Ramachandran (toim.) Encyclopedia of Cardiovascular Research and Medicine. Elsevier. s. 258-265. 2017 -
Enhancing Angiogenesis in Mice by VEGF-Targeting Small Activating RNAs
Turunen Tiia A, Ylä-Herttuala Seppo, Turunen Mikko P. Teoksessa: Long-Cheng Li (toim.) RNA Activation. Springer. Advances in Experimental Medicine and Biology 983. s. 195-205. 2017 -
Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor
Valkama, AJ; Leinonen, HM; Lipponen, EM; Turkki, V; Malinen, J; Heikura, T; Ylä-Herttuala, S; Lesch, HP. GENE THERAPY 2018; 25: 39-46. 2017 -
The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates
van Lith, SAM; van den Brand, D; Wallbrecher, R; Wübbeke, L; van Duijnhoven, SMJ; Mäkinen, PI; Hoogstad-van, Evert JS; Massuger, L; Ylä-Herttuala, S; Brock, R; Leenders, WPJ. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2018; 124: 63-72. 2017 -
Cardiac Lymphatics - A New Avenue for Therapeutics?
Vuorio Taina, Tirronen Annakaisa, Ylä-Herttuala Seppo. Trends in endocrinology and metabolism 28 4: 285-296. 2017 -
Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases
Wennink JWH, Liu Y, Mäkinen PI, Setaro F, de la Escosura A, Bourajjaj M, Lappalainen JP, Holappa LP, van den Dikkenberg JB, Al Fartousi M, Trohopoulos PN, Ylä-Herttuala S, Torres T, Hennink WE, van Nostrum CF. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 112-125. 2017 -
Cardiovascular gene therapy : past, present, and future
Ylä-Herttuala S, Baker AH. MOLECULAR THERAPY 25 5: 1095-1106. 2017 -
Angiogenic gene therapy in cardiovascular diseases: dream or vision?
Ylä-Herttuala S, Bridges C, Katz MG, Korpisalo P. EUROPEAN HEART JOURNAL 38 18: 1365-1371. 2017 -
ESGCT 2017 in Berlin: Clear Steps Forward
Ylä-Herttuala S. MOLECULAR THERAPY 25 12: 2599. 2017 -
Bumps in the Road for Commercial Gene Therapy for Rare Diseases
Ylä-Herttuala Seppo. MOLECULAR THERAPY 25 10: 2225. 2017 -
Call for Papers in the Area of Cardiovascular Regenerative Medicine
Ylä-Herttuala Seppo. MOLECULAR THERAPY 25 9: 1989. 2017 -
Geenihoidot: haasteita ja suuria lupauksia
Ylä-Herttuala Seppo. Teoksessa: Jokela Maarit, Oja-Leikas Mirkka, Rova Meri (toim.) Kiehtovat geenit: Mihin geenititetoa käytetään?. Duodecim. s. 88-94. 2017 -
The Pharmacology of Gene Therapy
Ylä-Herttuala Seppo. MOLECULAR THERAPY 25 8: 1731-1732. 2017 -
Debate on Germline Gene Editing
Cartier-Lacave N, Ali R, Ylä-Herttuala S, Kato K, Baetschi B, Lovell-Badge R, Naldini L, Thrasher A. HUMAN GENE THERAPY METHODS 27 4: 135-142. 2016 -
Does Vascular Endothelial Growth Factor Gene Therapy Safely Improve Outcome in Severe Early-Onset Fetal Growth Restriction? (EVERREST)
David Anna, Ashcroft Richard, Ylä-Herttuala Seppo, Hecher Kurt, Figueras Francesc, Marsal Karel, Sleigh Sara, Brookes Jocelyn, Campbell David. Human Gene Therapy Clinical Development June 2015, 26 2: 82-84. 2016 -
Call for papers: Nanoparticle Development and Applications in Cellular and Molecular Therapies
Frederickson RM, Moghimi SM, Wagner E, Yla-Herttuala S. MOLECULAR THERAPY 2017; 24 8: 1334-1335. 2016 -
Writing the Next Chapter for the Molecular Therapy Family of Journals
Frederickson Robert M, Ylä-Herttuala Seppo. MOLECULAR THERAPY 24 10: 1707. 2016 -
Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
Gallini R, Huusko J, Ylä-Herttuala S, Betsholtz C, Andrae J. PLOS ONE 11 8: e0160930. 2016 -
Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography
Hassinen Iiro, Kivelä Antti, Hedman Antti, Saraste Antti, Knuuti Juhani, Hartikainen Juha, Ylä-Herttuala Seppo. Human gene therapy 27 10: 830-834. 2016 -
Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine
Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 15: 26. 2016 -
18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice
Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Savisto N, Li XG, Thiele A, Lehmann L, Heinrich T, Vollmer S, Hakovirta H, Laine VJ, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. JOURNAL OF NUCLEAR CARDIOLOGY 2017; 24 3: 862-871. 2016 -
Activation of peroxisome proliferator-activated receptor-delta as novel therapeutic strategy to prevent in-stent restenosis and stent thrombosis
Hytönen J, Leppänen O, Braesen JH, Schunck W-H, Mueller D, Jung F, Mrowietz C, Jastroch M, Von Bergwelt-Baildon M, Kappert K, Heuser A, Drenckhahn J-D, Pieske B, Thierfelder L, Ylä-Herttuala S, Blaschke F. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 36 8: 1534-1548. 2016 -
Tie1 controls angiopoietin function in vascular remodeling and inflammation
Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P.. JOURNAL OF CLINICAL INVESTIGATION 126 9: 3495-3510. 2016 -
Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8
Laakkonen Johanna P, Lappalainen Jari P, Theelen Thomas L, Toivanen Pyry I, Nieminen Tiina, Jauhiainen Suvi,Kaikkonen Minna U, Sluimer Judith C, Ylä-Herttuala Seppo. Angiogenesis [Epub ahead of print 21 Nov 2016]: 1-16. 2016 -
Animal Models of Gene Therapy for Cardiovascular Disease
Laakkonen Johanna P, Ylä-Herttuala Seppo. Teoksessa: David T. Curiel (toim.) Adenoviral Vectors for Gene Therapy. Elsevier. s. 691-705. 2016 -
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Muhl L, Moessinger C, Adzemovic MZ, Dijkstra MH, Nilsson I, Zeitelhofer M, Hagberg CE, Huusko J, Falkevall A, Ylä-Herttuala S, Eriksson U. CELL AND TISSUE RESEARCH 365 1: 51-63. 2016 -
Peroxisome Proliferator-activated Receptor-gamma Coactivator 1 alfa1 Induces a Cardiac Excitation-contraction Coupling Phenotype Without Metabolic Remodelling
Mutikainen Maija, Tuomainen Tomi, Naumenko Nikolay, Huusko Jenni, Smirin Boris, Laidinen S, Kokki K, Hynynen H, Ylä-Herttuala S, Heinäniemi M, Ruas JL, Tavi P. JOURNAL OF PHYSIOLOGY (CAMBRIDGE) 594 23: 7049-7071. 2016 -
AdVEGF-B186 and AdVEGF-D(Delta)N(Delta)C induce angiogenesis and increase perfusion in porcine myocardium
Nurro Jussi, Halonen Paavo J, Kuivanen Antti, Tarkia Miikka, Saraste Antti, Honkonen Krista, Lähteenvuo Johanna, Rissanen Tuomas T, Knuuti Juhani, Ylä-Herttuala Seppo. Heart 102 21: 1716-1720. 2016 -
Smooth muscle cell foam cell formation, apolipoproteins, and ABCA1 in intracranial aneurysms: implications for lipid accumulation as a promoter of aneurysm wall rupture
Ollikainen Eliisa, Tulamo Riikka, Lehti Satu, Lee-Rueckert Miriam, Hernesniemi Juha, Niemela Mika, Ylä-Herttuala Seppo, Kovanen Petri T, Frösen Juhana. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (LAWRENCE KS) 75 7: 689-699. 2016 -
Development of lentiviral vectors for targeted integration and protein delivery
Schenkwein D, Ylä-Herttuala S. Teoksessa: Maurizio Federico (toim.) Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools. Springer science+business media. Methods in Molecular Biology 1448, Part III. s. 185-198. 2016 -
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, Andersson P, Nakamura M, Näslund E, Ylä-Herttuala S, Sun M, Iwamoto H, Li X, Liu Y, Samani NJ, Cao Y. Nature Communications 7: 12152. 2016 -
Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques
Silvola Johanna MU, Virtanen Helena, Siitonen Riikka, Hellberg Sanna, Liljenbäck Heidi, Metsälä Olli, Ståhle Mia, Saanijoki Tiina, Käkelä Meeri, Hakovirta Harri, Ylä-Herttuala Seppo, Saukko Pekka, Jauhiainen Matti, Veres Tibor Z, Jalkanen Sirpa, Knuuti Juhani, Saraste Antti, Roivainen Anne. Scientific Reports 6: 35089. 2016 -
Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia
Turunen Tytteli AK, Kurkipuro Jere, Heikura Tommi, Vuorio Taina, Hytönen Elisa, Izsvák Zsuzsanna, Ylä-Herttuala Seppo. MOLECULAR THERAPY 24 3: 620-635. 2016 -
In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued
van Lith SA, Roodink I, Verhoeff JJ, Mäkinen PI, Lappalainen JP, Ylä-Herttuala S, Raats J, van Wijk E, Roepman R, Letteboer SJ, Verrijp K, Leenders WP. Oncotarget 7 44: 71594-71607. 2016 -
ADA-SCID Gene Therapy Endorsed By European Medicines
Ylä-Herttuala Seppo. MOLECULAR THERAPY 2017; 24 6: 1013-1014. 2016 -
CardioPulse: Progress in gene therapy for cardiovascular disease
Ylä-Herttuala Seppo. EUROPEAN HEART JOURNAL 37 14: 1093. 2016 -
Onkolyyttinen virusgeeniterapia tulossa metastasoituneen melanooman hoitoon
Ylä-Herttuala Seppo. DUODECIM 132 4: 297-8. 2016 -
Täsmähoidot tuovat uutta toivoa monille syöpäpotilaille
Ylä-Herttuala Seppo. KANSANTERVEYS - 5: -. 2016 -
Geeni- ja soluterapia
Ylä-Herttuala, S, Wartiowaara K. Teoksessa: Aittomäki K, Moilanen J, Perola M (toim.) Lääketieteellinen genetiikka. Duodecim. s. 393-404. 2016 -
Epigeneettiset muutokset ja mikro-RNA-klusterin aktivoituminen ateroskleroosiplakeissa
Aavik Einari, Lumivuori Henri, Leppänen Olli, Wirth Thomas, Häkkinen Sanna-Kaisa, Bräsen Jan-Hinrich, Beschorner Ulrich, Zeller Thomas, Braspenning Maarten, van Criekinge Wim, Mäkinen Kimmo, Ylä-Herttuala Seppo. DUODECIM 131 4: 355. 2015 -
Baculovirus: A High-Capacity Vector for Versatile Gene Transfer
Airenne Kari J, Ylä-Herttuala Seppo. Nancy Smyth Templeton, Gene and Cell Therapy : Therapeutic Mechanisms and Strategies. Fourth Edition. 201-236. 2015 -
Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study
Babu Mohan, Durga Devi Thota, Mäkinen Petri, Kaikkonen Minna, Lesch Hanna P, Junttila Sini, Laiho Asta, Ghimire Bishwa, Gyenesei Attila, Ylä-Herttuala Seppo. CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 117: 289-299. 2015 -
Molecular Therapy Special Issue on Gene Editing Technologies and Applications
Frederickson Robert, Ylä-Herttuala Seppo. MOLECULAR THERAPY 23 8: 1279. 2015 -
Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches
Heinonen Suvi E, Guillem Genové, Bengtsson Eva, Hübschle Thomas, Åkesson Lina, Hiss Katrin, Benardeau Agnes, Ylä-Herttuala Seppo, Jönsson-Rylander Ann-Cathrine, Gomez Maria F. Journal of Diabetes Research 2015: 14 p. 2015 -
Regulation of VEGF-A Expression in Endothelial Cells by Transcriptional Gene Activation or Transcriptional Gene Silencing: Analysis of Genome Wide Transcriptional Response
Husso Tiia, Turunen Mikko P, Ylä-Herttuala Seppo. Gene Technology 4 2: 122. 2015 -
Prospect and progress of gene therapy in treating atherosclerosis
Kivelä Annukka M, Huusko Jenni, Ylä-Herttuala Seppo. EXPERT OPINION ON BIOLOGICAL THERAPY 15 12: 1699-1712. 2015 -
Novel Nuclear Biology of Small Non-Coding RNAs
Kolari Ida-Liisa, Laitinen Pia, Turunen Mikko P, Ylä-Herttuala Seppo. Gene Technology 4: 120. 2015 -
Recent Advancements in Cardiovascular Gene Therapy and Vascular Biology
Laakkonen Johanna P., Ylä-Herttuala Seppo. HUMAN GENE THERAPY 26 8: 518-524. 2015 -
Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
Laham-Karam Nihay, Lalli Marianne, Leinonen Nastasia, Ylä-Herttuala Seppo. Molecular Therapy - Nucleic Acids 4: e243. 2015 -
Process Development of Adenoviral Vector Production in Fixed Bed Bioreactor: From Bench to Commercial Scale
Lesch Hanna P, Heikkilä Kati M, Lipponen Eevi M, Valonen Piia, Müller Achim, Räsänen Eva, Tuunanen Tarja, Hassinen Minna M, Parker Nigel, Karhinen Minna, Shaw Robert, Ylä-Herttuala Seppo. HUMAN GENE THERAPY 26 8: 560-571. 2015 -
Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction
Madonna Rosalinda, Petrov Lyobomir, Teberino Maria Anna, Manzoli Lamberto, Karam Jean-Pierre, Renna Francesca Vera, Ferdinandy Peter, Montero-Menei Claudia N, Ylä-Herttuala Seppo, De Caterina Raffaele. CARDIOVASCULAR RESEARCH 108 1: 39-49. 2015 -
Baculovirus-mediated Gene Delivery and RNAi Applications
Makkonen Kaisa-Emilia, Airenne Kari, Ylä-Herttuala Seppo. Viruses 7 4: 2099-2125. 2015 -
Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice
Merentie M, Lipponen JA, Hedman M, Hedman A, Hartikainen J, Huusko J, Lottonen-Raikaslehto L, Parviainen V, Laidinen S, Karjalainen PA, Ylä-Herttuala S. PSYCHOLOGICAL REPORTS 3: e12639. 2015 -
Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in mouse heart
Merentie M, Lottonen-Raikaslehto L, Parviainen V, Huusko J, Pikkarainen S, Mendel M, Laham-Karam N, Kärjä V, Hedman M, Ylä-Herttuala S. GENE THERAPY [epub ahead of print Dec 24, 2015]: -. 2015 -
Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation
Nguyen Su Duy, Javanainen Matti, Rissanen Sami, Zhao Hongxia, Huusko Jenni, Kivelä Annukka M, Ylä-Herttuala Seppo, Navab Mohamad, Fogelman Alan M, Vattulainen Ilpo, Kovanen Petri T, Öörni Katariina. JOURNAL OF LIPID RESEARCH 56: 1206-1221. 2015 -
Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity
Nieminen Tiina, Toivanen Pyry I, Laakkonen Johanna P, Heikura Tommi, Kaikkonen Minna U, Airenne Kari J, Ylä-Herttuala Seppo. CARDIOVASCULAR RESEARCH 107 2: 267-276. 2015 -
Tomato thymidine kinase-based suicide gene therapy for malignant glioma - an alternative for Herpes Simplex virus-1 thymidine kinase
Stedt H, Samaranayake H, Kurkipuro J, Wirth G, Christiansen LS, Vuorio T, Määttä A-M, Piškur J, Ylä-Herttuala S. CANCER GENE THERAPY 22: 130-137. 2015 -
Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice
Sunkari Vivekananda Gupta, Lind Folke, Botusan Ileana Ruxandra, Kashif Abad, Liu Zhao-Jun, Ylä-Herttuala Seppo, Brismar Kerstin, Velazquez Omaida, Catrina Sergiu-Bogdan. Wound Repair and Regeneration 23 1: 98-103. 2015 -
Growth factor therapy and lymph node graft for lymphedema
Tervala Tomi V, Hartiala Pauliina, Tammela Tuomas, Visuri Mikko T, Ylä-Herttuala Seppo, Alitalo Kari, Saarikko Anne M. Journal of Surgical Research 196 1: 200-207. 2015 -
Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice
Theelen Thomas L, Lappalainen Jari P, Sluimer Judith C, Gurzeler Erika, Cleutjens Jack P, Gijbels Marion J, Biessen Erik AL, Daemen Mat JAP, Alitalo Kari, Ylä-Herttuala Seppo. ATHEROSCLEROSIS 241 2: 297-304. 2015 -
Platelet-Derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury
Tuuminen R, Dashkevich A, Keränen MA, Raissadati A, Krebs R, Jokinen JJ, Arnaudova R, Rouvinen E, Ylä-Herttuala S, Nykänen AI, Lemström KB. TRANSPLANTATION [epub ahead of print Sep 14 2015]: -. 2015 -
Verihiutalekasvutekijä B suojaa rotan siirtosydäntä iskemia-reperfuusiovauriolta
Tuuminen Raimo, Dashkevich Alexey, Keränen Mikko AI, Raissadati Alireza, Krebs Rainer, Jokinen Janne J, Arnaudova Ralica, Rouvinen Eeva, Ylä-Herttuala Seppo, Nykänen Antti I, Lemström Karl B. DUODECIM 131 19: 1821. 2015 -
VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study
Visuri Mikko T, Honkonen Krista M, Hartiala Pauliina, Tervala Tomi V, Halonen Paavo J, Junkkari Heikki, Knuutinen Nina, Ylä-Herttuala Seppo, Alitalo Kari K, Saarikko Anne M. Angiogenesis 18 3: 313-326. 2015 -
Foreword: Gene and Cell Therapy Matures to the Clinics
Ylä-Herttuala Seppo. Nancy Smyth Templeton, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Edition. xi-xii. 2015 -
From the Impact Factor to DORA and the Scientific Content of Articles
Ylä-Herttuala Seppo. MOLECULAR THERAPY 23 4: 609. 2015 -
Gene Therapy for Heart Failure: Back to the Bench
Ylä-Herttuala Seppo. MOLECULAR THERAPY 23 10: 1551-1552. 2015 -
Gene Therapy in Nordic Countries
Ylä-Herttuala Seppo. HUMAN GENE THERAPY 26 8: 473-474. 2015 -
Glybera's Second Act: The Curtain Rises on the High Cost of Therapy
Ylä-Herttuala Seppo. MOLECULAR THERAPY 23 2: 217-218. 2015 -
The Molecular Therapy Family: Past, Present, and Future
Ylä-Herttuala Seppo. MOLECULAR THERAPY 23 1: 1. 2015 -
Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster
Aavik E, Lumivuori H, Leppänen O, Wirth T, Häkkinen SK, Bräsen JH, Beschorner U, Zeller T, Braspenning M, van Criekinge W, Mäkinen K, Ylä-Herttuala S. EUROPEAN HEART JOURNAL 2014 Nov 16. pii: ehu437.: - -. 2014 -
Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
Dijkstra MH, Pirinen E, Huusko J, Kivelä R, Schenkwein D, Alitalo K, Ylä-Herttuala S. Scientific Reports 4, Article number:6238: --. 2014 -
14q32 miRNA Cluster Takes Center Stage in Neovascularization
Dimmeler Stefanie, Ylä-Herttuala Seppo. CIRCULATION RESEARCH 115 8: 680-682. 2014 -
Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma
Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M. DRUG METABOLISM AND DISPOSITION 2015; 43: 140-146. 2014 -
Current gene therapy trials for vascular diseases
Halonen Paavo J, Nurro Jussi, Kuivanen Antti, Ylä-Herttuala Seppo. EXPERT OPINION ON BIOLOGICAL THERAPY 2014 Mar;14(3): 327-336. 2014 -
A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
Husso Tiia, Ylä-Herttuala Seppo, Turunen Mikko P. Molecular Therapy - Nucleic Acids (2014) 3, e197: --. 2014 -
Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization
Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S. NUCLEIC ACIDS RESEARCH 42 20: 12570-84. 2014 -
Feasibility of experimental BT4C glioma models for somatostatin receptor 2-targeted therapies
Kiviniemi Aida, Gardberg Maria, Autio Anu, Li Xiang-Guo, Heuser Vanina D, Liljenbäck Heidi, Käkelä Meeri, Sipilä Henri, Kurkipuro Jere, Ylä-Herttuala Seppo, Knuuti Juhani, Minn Heikki, Roivainen Anne. ACTA ONCOLOGICA 53 8: 1125-34. 2014 -
Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities
Korpisalo P, Hytönen JP, Laitinen JT, Närväinen J, Rissanen TT, Gröhn OH, Ylä-Herttuala S. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 307 8: H1226-H1232. 2014 -
Reply to Heparan Sulfate in Baculovirus Binding and Entry of Mammalian Cells
Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ. JOURNAL OF VIROLOGY 88 8: 4609-1460. 2014 -
HIF-1 alpha and HIF-2 alpha induce angiogenesis and improve muscle energy recovery
Niemi Henna, Honkonen Krista, Korpisalo Petra, Huusko Jenni, Kansanen Emilia, Merentie Mari, Rissanen Tuomas T, André Helder, Pereira Teresa, Poellinger Lorenz, Alitalo Kari, Ylä-Herttuala Seppo. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 44 10: 989-999. 2014 -
Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling
Ronkainen Veli-Pekka, Tuomainen Tomi, Huusko Jenni, Laidinen Svetlana, Malinen Marjo, Palvimo Jorma J, Ylä-Herttuala Seppo, Vuolteenaho Olli, Tavi Pasi. CARDIOVASCULAR RESEARCH 2014 Jan 1;101(1): 69-77. 2014 -
Clonal variation in interferon response determines the outcome of oncolytic virotherapy in mouse CT26 colon carcinoma model
Ruotsalainen JJ, Kaikkonen MU, Niittykoski M, Martikainen MW, Lemay CG, Cox J, De Silva NS, Kus A, Falls TJ, Diallo JS, Le Boeuf F, Bell JC, Ylä-Herttuala S, Hinkkanen AE, Vähä-Koskela MJ. GENE THERAPY 2014 Sep 18. [Epub ahead of print]: --. 2014 -
Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
Sallinen H, Heikura T, Koponen J, Kosma VM, Heinonen S, Ylä-Herttuala S, Anttila M. BMC CANCER [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/BMCCANCER/] 14 1: 1-10. 2014 -
Soluble Vascular Endothelial Growth Factor Receptor-1 Improves Therapeutic Efficacy of Suicide Gene Therapy in an Angiogenesis-Independent Manner
Samaranayake Haritha D, Pikkarainen Jere T, Wirth Thomas, Stedt Hanna, Lesch Hanna P, Dragneva Galina, Vuorio Taina, Määttä Ann-Mari, Airenne Kari, Ylä-Herttuala Seppo. HUMAN GENE THERAPY 25 11: 942-954. 2014 -
Analysis of fat graft metabolic adaptation and vascularization using positron emission tomography-computed tomographic imaging
Tervala TV, Grönroos TJ, Hartiala P, Nuutila P, Suominen EA, Karra H, Kivinen K, Ylä-Herttuala S, Saarikko AM. PLASTIC AND RECONSTRUCTIVE SURGERY 133 2: 291-299. 2014 -
Lentiviral protein transduction with genome-modifying HIV-1 integrase-I-PpoI fusion proteins: studies on specificity and cytotoxicity
Turkki Vesa, Schenkwein Diana, Timonen Oskari, Husso Tiia, Lesch Hanna P, Ylä-Herttuala Seppo. BioMed research international 2014;2014:379340.: Article ID 379340. 2014 -
Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice
Turunen Mikko P, Husso Tiia, Musthafa Haja, Laidinen Svetlana, Dragneva Galina, Laham-Karam Nihay, Honkanen Sanna, Paakinaho Anne, Laakkonen Johanna P, Gao Erhe, Vihinen-Ranta Maija, Liimatainen Timo, Ylä-Herttuala Seppo. PLOS ONE [ONLINE] 2014 Feb 26;9(2):e89979: e89979. 2014 -
Sleeping Beauty-baculovirus hybrid vectors for long-term gene expression in the eye
Turunen Tytteli AK, Laakkonen Johanna P, Alasaarela Laura, Airenne Kari J, Ylä-Herttuala Seppo. JOURNAL OF GENE MEDICINE 16 1-2: 40-53. 2014 -
[F-18]Fluorodeoxyglucose Uptake in Atherosclerotic Plaques Is Associated With Reduced Coronary Flow Reserve in Mice
Uotila Sauli, Silvola Johanna MU, Saukko Pekka, Nuutila Pirjo, Heinonen Suvi E, Ylä-Herttuala Seppo, Roivainen Anne, Knuuti Juhani, Saraste Antti. JOURNAL OF ULTRASOUND IN MEDICINE 33 11: 1941-1948. 2014 -
Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis
Vuorio Taina, Nurmi Harri, Moulton Karen, Kurkipuro Jere, Robciuc Marius R, Öhman Miina, Heinonen Suvi E, Samaranayake Haritha, Heikura Tommi, Alitalo Kari, Ylä-Herttuala Seppo. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 2014 Jun;34(6): 1162-70. 2014 -
Gene Therapy Used in Cancer Treatment
Wirth Thomas, Ylä-Herttuala Seppo. Biomedicines 2014, 2(2): 149-162. 2014 -
Gene transfer vectors (DNA vehicles) and their incorporation into biomaterials for bone repair
Wirth Thomas, Ylä-Herttuala Seppo. Teoksessa: Dubruel P, Vlierberghe SV (eds.) (toim.) Biomaterials for Bone Regeneration: Novel Techniques and Applications: Novel Techniques and Applications. ELSEVIER. s. 374-405. 2014 -
Does mass balance between sense and antisense transcripts fine-tune the outcome of gene expression?
Ylä-Herttuala Seppo, Kaikkonen Minna. EMBO REPORTS 2014 Feb;15(2): 125-126. 2014 -
Research update for articles published in EJCI in 2011
Abete P, Adlbrecht C, Assimakopoulos S, Cote N, Dullaart R, Evsyukova H, Fang T, Goswami N, Hinghofer-Szalkay H, Ho Y, Hoebaus C, lsmann M, Indridason O, Kholova I, Lin Y, Maniscalco M, Mathieu P, Mizukami H, Ndrepepa G, Roessler A, Sanchez-Ramon S, Santamaria F, Schernthaner G, Scopa C, Sharp K, Skuladottir G, Steichen O, Stenvinkel P, Tejera-Alhambra M, Testa G, Visseren F, Westerink J, Witasp A. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Volume 43, Issue 10: 1097-111. 2013 -
Baculovirus: an insect-derived vector for diverse gene transfer applications
Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, Matsuura Y, Wang S, Ylä-Herttuala S. MOLECULAR THERAPY 21 4: 739-49. 2013 -
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis
Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Dejana E, Koh GY, Choi C, Saharinen P, Alitalo K. CIRCULATION 2013 Jan 29;127(4): 424-34. 2013 -
The Genetic and Metabolic Determinants of Cardiovascular Complications in Type 2 Diabetes: Recent Insights from Animal Models and Clinical Investigations
Avramoglu RK, Laplante M-A, Quang KL, Deshaies Y, Despres J-P, Larose E, Mathieu P, Poirier P, Perusse L, Vohl M-C, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A. Canadian Journal of Diabetes 37 5: 351-358. 2013 -
Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)
Chow BJ, Green RE, Coyle D, Laine M, Hanninen H, Leskinen H, Rajda M, Larose E, Hartikainen J, Hedman M, Mielniczuk L, O Meara E, Dekemp RA, Klein R, Paterson I, White JA, Yla-Herttuala S, Leber A, Tandon V, Lee T, Al-Hesayen A, Hessian R, Dowsley T, Kass M, Kelly C, Garrard L, Tardif JC, Knuuti J, Beanlands RS, Wells GA.. TRIALS [ONLINE] 14: 443. 2013 -
Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
Dragneva G, Korpisalo P, Ylä-Herttuala S. Disease models & mechanisms 2013 Mar;6(2): 312-22. 2013 -
Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall
Frösen J, Tulamo R, Heikura T, Sammalkorpi S, Niemelä M, Hernesniemi J, Levonen AL, Hörkkö S, Ylä-Herttuala S. Acta neuropathologica communications 1: 71. 2013 -
Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial
Gomes RS, das Neves RP, Cochlin L, Lima A, Carvalho R, Korpisalo P, Dragneva G, Turunen M, Liimatainen T, Clarke K, Ylä-Herttuala S, Carr C, Ferreira L. ACS NANO 2013 Apr 23;7(4): 3362-72. 2013 -
The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models
Heinonen SE, Kivelä AM, Huusko J, Dijkstra MH, Gurzeler E, Mäkinen PI, Leppänen P, Olkkonen VM, Eriksson U, Jauhiainen M, Ylä-Herttuala S.. CARDIOVASCULAR RESEARCH 99 4: 716-23. 2013 -
Biodistribution and antitumor effect of Cetuximab-targeted lentivirus
Huhtala Tuulia, Kaikkonen Minna U, Lesch Hanna P, Viitala Sari, Ylä-Herttuala Seppo, Närvänen Ale. NUCLEAR MEDICINE AND BIOLOGY 2014:41: 77-83. 2013 -
Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells
Ivanov KI, Agalarov Y, Valmu L, Samuilova O, Liebl J, Houhou N, Maby-El Hajjami H, Norrmén C, Jaquet M, Miura N, Zangger N, Ylä-Herttuala S, Delorenzi M, Petrova TV. MOLECULAR AND CELLULAR BIOLOGY 2013 Oct;33(19): 3749-6. 2013 -
Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia
Jazwa A, Tomczyk M, Taha HM, Hytonen E, Stoszko M, Zentilin L, Giacca M, Yla-Herttuala S, Emanueli C, Jozkowicz A, Dulak. Vascular cell 2013 Jul 1;5(1):13.: - -. 2013 -
LDLR(-/-)ApoB(100/100) mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina
Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Järvinen H, Uusitalo H, Ylä-Herttuala S. MOLECULAR VISION [ONLINE: HTTP://WWW.MOLVIS.ORG/MOLVIS/] 19: 1723-1733. 2013 -
Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models
Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM [PRINTED AND ONLINE: HTTP://AJPENDO.PHYSIOLOGY.ORG/] vol. 305 no. 5: E573-E584. 2013 -
6-O sulfated and N-sulfated Syndecan-1 promotes baculovirus binding and entry into mammalian cells
Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ. JOURNAL OF VIROLOGY 2013 Oct;87 20: 11148-59. 2013 -
Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis
Mäkinen PI, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 2013 Apr;24(2): 116-22. 2013 -
The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features
Nieminen T, Toivanen PI, Rintanen N, Heikura T, Jauhiainen S, Airenne KJ, Alitalo K, Marjomäki V, Ylä-Herttuala S. BIOCHIMICA ET BIOPHYSICA ACTA 1840 1: 454-463. 2013 -
Routine versus selective cardiac magnetic resonance in non-ischemic heart failure - OUTSMART-HF: study protocol for a randomized controlled trial (IMAGE-HF (heart failure) project 1-B)
Paterson I, Wells GA, Ezekowitz JA, White JA, Friedrich MG, Mielniczuk LM, O'Meara E, Chow B, DeKemp RA, Klein R, Dennie C, Dick A, Coyle D, Dwivedi G, Rajda M, Wright GA, Laine M, Hanninen H, Larose E, Connelly KA, Leong-Poi H, Howarth AG, Davies RA, Duchesne L, Yla-Herttuala S, Saraste A, Farand P, Garrard L, Tardif JC, Arnold M, Knuuti J, Beanlands R, Chan KL. TRIALS [ONLINE] 2013 Oct 12;14:332.: --. 2013 -
Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. ANTIOXIDANTS AND REDOX SIGNALING 2013 Aug 20. [Epub ahead of print]: x-x. 2013 -
The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs
Rissanen TT, Nurro J, Halonen PJ, Tarkia M, Saraste A, Rannankari M, Honkonen K, Pietilä M, Leppänen O, Kuivanen A, Knuuti J, Ylä-Herttuala S. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 305 9: H1297-308. 2013 -
The absence of macrophage Nrf2 promotes early atherogenesis
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. CARDIOVASCULAR RESEARCH 2013 Apr 1;98(1): 107-15. 2013 -
Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide
Stedt H, Samaranayake H, Pikkarainen J, Määttä AM, Alasaarela L, Airenne K, Ylä-Herttuala S. GENE THERAPY 20: --. 2013 -
Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model
Tuppurainen L, Sallinen H, Hakkarainen H, Liimatainen T, Hassan M, Ylä-Herttuala E, Anttila M, Hämäläinen K, Veli-Matti Kosma, Heinonen S, Alitalo K, Ylä-Herttuala S. Journal of Genetic Syndromes & Gene Therapy 4 8: x-x. 2013 -
Preclinical Safety, Toxicology, and Biodistribution Study of Adenoviral Gene Therapy with sVEGFR-2 and sVEGFR-3 Combined with Chemotherapy for Ovarian Cancer
Tuppurainen L, Sallinen H, Kokki E, Koponen J, Anttila M, Pulkkinen K, Heikura T, Toivanen P, Hämäläinen K, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. Human Gene Therapy Clinical Development 24 1: 29-37. 2013 -
Cell susceptibility to baculovirus transduction and echovirus infection is modified by PKC phosphorylation and vimentin organization
Turkki P, Makkonen KE, Huttunen M, Laakkonen JP, Ylä-Herttuala S, Airenne KJ, Marjomäki V. JOURNAL OF VIROLOGY 2013 Jul 3. [Epub ahead of print]: [Epub ahead of print]. 2013 -
Epigenetic regulation in vascular cells
Turunen MP, Aavik E, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 2013 Jul 18. [Epub ahead of print] 24: x-x. 2013 -
Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial
Westphal M, Ylä-Herttuala S, Martin J, Warnke P, Menei P, Eckland D, Kinley J, Kay R, Ram Z; ASPECT Study Group. LANCET ONCOLOGY 14 9: 823-33. 2013 -
History of gene therapy
Wirth T, Parker N, Ylä-Herttuala S. GENE 2013 Aug 10;525(2): 162-9. 2013 -
Modified RNA kick-starts cardiac repair
Ylä-Herttuala S, Aavik E. NATURE BIOTECHNOLOGY 2013 Oct;31(10):: 891-2. 2013 -
Stabilization of atherosclerotic plaques: an update
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgözoglu L; ESC Working Group of Atherosclerosis and Vascular Biology. EUROPEAN HEART JOURNAL 34 42: 3251-8. 2013 -
Cardiovascular gene therapy with vascular endothelial growth factors
Ylä-Herttuala S. GENE 2013 Aug 10;525(2): 217-9. 2013 -
Geeniterapialääkkeet tekevät tuloaan
Ylä-Herttuala S. DUODECIM 2013;129(8): 788-9. 2013 -
Epigenetics and Atherosclerosis
Aavik Einari, Turunen Mikko P, Ylä-Herttuala Seppo. Teoksessa: Minarovits Janos, Niller Hans Helmut (toim.) Patho-Epigenetics of Disease. Springer science+business media. s. 397-418. 2012 -
Baculovirus-mediated vascular endothelial growth factor-D∆ N∆ C gene transfer induces angiogenesis in rabbit skeletal muscle
Heikura T, Nieminen T, Roschier MM, Karvinen H, Kaikkonen MU, Mähönen AJ, Lesch HP, Rissanen TT, Laitinen OH, Airenne KJ, Ylä-Herttuala S.. 2012. Baculovirus-mediated vascular endothelial growth factor-D∆N∆C gene transfer induces angiogenesis in rabbit skeletal muscle. JOURNAL OF GENE MEDICINE 14 1: 35-43. 2012 -
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis
Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. JOURNAL OF THE NATIONAL CANCER INSTITUTE 2012 Mar 21;104(6): 461-75. 2012 -
Lymph Node Transfer and Perinodal Lymphatic Growth Factor Treatment for Lymphedema
Honkonen KM, Visuri MT, Tervala TV, Halonen PJ, Koivisto M, Lähteenvuo MT, Alitalo KK, Ylä-Herttuala S, Saaristo AM. Annals of surgery 2012 Sep 25. [Epub ahead of print]: - -. 2012 -
AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy
Huusko J, Lottonen L, Merentie M, Gurzeler E, Anisimov A, Miyanohara A, Alitalo K, Tavi P, Ylä-Herttuala S. MOLECULAR THERAPY 20 (2012): 2212 - 2221. 2012 -
Gene therapy in age related and hereditary macular disorders
Kinnunen, K; Ylä-Herttuala, S. FRONTIERS IN BIOSCIENCE 4: 2546-2557. 2012 -
Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
Kivelä A, Hartikainen J, Ylä-Herttuala S. BMC CARDIOVASCULAR DISORDERS [ONLINE: HTTP://WWW.BIOMEDCENTRAL.COM/1471-2261/] 2012 Oct 17;12:91.: --. 2012 -
Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A
Kivelä AM, Dijkstra MH, Heinonen SE, Gurzeler E, Jauhiainen S, Levonen AL, Ylä-Herttuala S. ATHEROSCLEROSIS 2012 Oct 9. [Epub ahead of print] pii: S0021-9150(12)00657-0.: --. 2012 -
Endothelium-specific overexpression of human vascular endothelial growth factor-D in mice leads to increased tumor frequency and a reduced lifespan
Kotimaa AA, Zainana AM, Pulkkinen E, Huusko J, Heinonen SE, Kholová I, Stedt H, Lesch HP, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 2012 Mar;14(3): 182-90. 2012 -
Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis
Krebs R, Tikkanen JM, Ropponen JO, Jeltsch M, Jokinen JJ, Ylä-Herttuala S, Nykänen AI, Lemström KB. AMERICAN JOURNAL OF PATHOLOGY 2012 Nov;181(5): 1607-20. 2012 -
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy
Kuusisto J, Kärjä V, Sipola P, Kholová I, Peuhkurinen K, Jääskeläinen P, Naukkarinen A, Ylä-Herttuala S, Punnonen K, Laakso M. HEART 98 13: 1007-1013. 2012 -
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. CANCER RESEARCH 2012 Oct 9. [Epub ahead of print]: - -. 2012 -
In vitro targeting of avidin-expressing glioma cells with biotinylated persistent luminescence nanoparticles
Maldiney T, Kaikkonen MU, Seguin J, le Masne de Chermont Q, Bessodes M, Airenne KJ, Ylä-Herttuala S, Scherman D, Richard C. BIOCONJUGATE CHEMISTRY 2012 Mar 21;23(3): 472-8. 2012 -
Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo
Murugan S, Saarela U, Airenne K, Shan J, Skovorodkin I, Ylä-Herttuala S, Vainio SJ. Genesis (New York, N.Y. : 2000) 2012 Sep;50(9): 693-9. 2012 -
Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo
Musthafa HS, Dragneva G, Lottonen L, Merentie M, Petrov L, Heikura T, Ylä-Herttuala E, Ylä-Herttuala S, Gröhn O, Liimatainen T. MAGNETIC RESONANCE IN MEDICINE 2012 Jun 26 [Epub ahead of print]: --. 2012 -
Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy
Pacholska A, Wirth T, Samaranayake H, Pikkarainen J, Ahmad F, Ylä-Herttuala S. CANCER GENE THERAPY 2012 Dec;19(12) Epub 2012 Oct 19: 870-4. 2012 -
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations
Partanen TA, Vuola P, Jauhiainen S, Lohi J, Salminen P, Pitkäranta A, Häkkinen SK, Honkonen K, Alitalo K, Ylä-Herttuala S. Angiogenesis 2012 Sep 9. [Epub ahead of print]: --. 2012 -
Diet intervention reduces uptake of α vβ 3 integrin-targeted PET tracer 18F-Galacto-RGD in mouse atherosclerotic plaques
Saraste A, Laitinen I, Weidl E, Wildgruber M, Weber AW, Nekolla SG, Hölzlwimmer G, Esposito I, Walch A, Leppänen P, Lisinen I, Luppa PB, Ylä-Herttuala S, Wester HJ, Knuuti J, Schwaiger M. 2012. Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-Galacto-RGD in mouse atherosclerotic plaques. JOURNAL OF NUCLEAR CARDIOLOGY 2012 Aug;19(4): 775-84. 2012 -
rDNA-directed integration by an HIV-1 integrase--I-PpoI fusion protein
Schenkwein D, Turkki V, Ahlroth MK, Timonen O, Airenne KJ, Ylä-Herttuala S. NUCLEIC ACIDS RESEARCH 2012 Dec 28. [Epub ahead of print]: --. 2012 -
Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes
Soininen Suvi K, Lehtolainen-Dalkilic Pauliina, Karppinen Tanja, Puustinen Tiina, Dragneva Galina, Kaikkonen Minna U, Jauhiainen Marjo, Allart Brigitte, Selwood David L, Wirth Thomas, Lesch Hanna P, Määttä Ann-Marie, Mönkkönen Jukka, Ylä-Herttuala Seppo, Ruponen Marika. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 47: 848-856. 2012 -
Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma
Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. INTERNATIONAL JOURNAL OF CANCER 131 10: 234-2401. 2012 -
Specific Inhibition of SRC Kinase Impairs Malignant Glioma Growth In Vitro and In Vivo
Stedt Hanna, Alasaarela Laura, Samaranayake Haritha, Pikkarainen Jere, Määttä Ann-Marie, Kholová Ivana, Parker Aaron S, Ylä-Herttuala Seppo. Molecular Therapy - Nucleic Acids 2012 May; 1(5): e19: - -. 2012 -
Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5
Toivonen R, Koskenvuo J, Merentie M, Söderström M, Ylä-Herttuala S, Savontaus M. Virology journal 2012 Nov 29;9(1):296. [Epub ahead of print]: - -. 2012 -
15-lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma
Viita H, Pacholska A, Ahmad F, Tietäväinen J, Naarala J, Hyvärinen A, Wirth T, Ylä-Herttuala S. IN VIVO (ATHENS) 2012 Jan-Feb;26(1): 1-8. 2012 -
Pro- and anti-angiogenic therapy and atherosclerosis with special emphasis on vascular endothelial growth factors
Vuorio, T., Jauhiainen, S., Ylä-Herttuala, S. EXPERT OPINION ON BIOLOGICAL THERAPY 2012 Jan;12(1): 79-92. 2012 -
The Syngeneic BT4C Rat Malignant Glioma is a Valuable Model to Study Myelomonocytic Cells in Tumors
Wirth T, Ahmad F, Pacholska A, Samaranayake H, Ylä-Herttuala S. Cancer Growth and Metastasis 2012:5: 19-25. 2012 -
Efficient gene therapy based targeting system for the treatment of inoperable tumors
Wirth T, Pikkarainen JT, Samaranayake HD, Lehtolainen-Dalkilic P, Lesch HP, Airenne KJ, Marjomäki V, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 2012 Apr;14(4): 221-30. 2012 -
The need for increased clarity and transparency in the regulatory pathway for gene medicines in the European Union
Ylä-Herttuala S. MOLECULAR THERAPY 2012 Mar;20(3): 471-2. 2012 -
Cardiovascular gene therapy trials
Ylä-Herttuala Seppo. Cohen-Haguenauer O, The clinibook - clinical gene transfer. 475-478. 2012 -
Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union
Ylä-Herttuala Seppo. MOLECULAR THERAPY 2012 Oct;20(10): 1831-2. 2012 -
General principles and approaches of gene therapy
Ylä-Herttuala Seppo. Teoksessa: Morishita R, Nakagami H (toim.), Gene Therapy: Technologies and Applications. Future Science Group (FSG) E-Book Series.. ss. --. 2012 -
Treatment of brain tumors with adenoviruses: preclinical development
Ylä-Herttuala Seppo. Cohen-Haguenauer O, The CliniBook: Clinical gene transfer. 242-244. 2012 -
Resectable VX-2 rabbit brain tumor model for development of intraoperative local administration of drugs
Ahmad Farizan, Pacholska Agnieszka, Tuppurainen Venla, Ylä-Herttuala Seppo, Hyvärinen Anna. ACTA NEUROCHIRURGICA (WIEN) 153: 1979-1981. 2011 -
Baculoviruses mediate efficient gene expression in a wide range of vertebrate cells
Airenne Kari J, Makkonen Kaisa-Emilia, Mähönen Anssi J, Ylä-Herttuala Seppo. Merten, O-W. ja Al-Rubeai, M., Viral Vectors for Gene Therapy. Methods and Protocols. Methods in Molecular Biology. 279-301. 2011 -
Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation.
Bhardwaj S, Roy H, Babu M, Shibuya M, Yla-Herttuala S. ATHEROSCLEROSIS 2011 Nov;219(1): 84-91. 2011 -
Progress and prospects: hurdles to cardiovascular gene therapy clinical trials
Hedman, Marja; Hartikainen, Juha; Ylä-Herttuala, Seppo. GENE THERAPY 18 8: 743-749. 2011 -
Baculovirus-mediated VEGF-D(Δ NΔ C) Gene Transfer Induces Angiogenesis In Rabbit Skeletal Muscle
Heikura T, Nieminen T, Roschier M, Karvinen H, Kaikkonen M, Mähönen A, Lesch H, Rissanen T, Laitinen O, Airenne K, Ylä-Herttuala S. 2011. Baculovirus-mediated VEGF-D(ΔNΔC) Gene Transfer Induces Angiogenesis In Rabbit Skeletal Muscle. JOURNAL OF GENE MEDICINE 2011 Dec 12: --. 2011 -
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 10: 1-12. 2011 -
Epigenetherapy, a new concept
Husso T, Turunen M, Parker N, Ylä-Herttuala S. BioMolecular Concepts Volume 2, Issue 3: 127-134. 2011 -
Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects
Jauhiainen Suvi, Häkkinen Sanna-Kaisa, Toivanen Pyry I, Heinonen Suvi E, Jyrkkänen Henna-Kaisa, Kansanen Emilia, Leinonen Hanna, Levonen Anna-Liisa, Ylä-Herttuala Seppo. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 31: 1617-1624. 2011 -
Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2
Jyrkkänen HK, Kuosmanen S, Heinäniemi M, Laitinen H, Kansanen E, Mella-Aho E, Leinonen H, Ylä-Herttuala S, Levonen AL. BIOCHEMICAL JOURNAL 2011 Dec 1;440(2): 167-74. 2011 -
How to avoid complement attack in baculovirus-mediated gene delivery
Kaikkonen Minna U, Ylä-Herttuala Seppo, Airenne Kari J. JOURNAL OF INVERTEBRATE PATHOLOGY 107: S71-S79. 2011 -
Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion
Kalén Mattias, Heikura Tommi, Karvinen Henna, Nitzsche Anja, Weber Holger, Esser Norbert, Ylä-Herttuala Seppo, Hellström Mats. PLOS ONE [ONLINE] 6: e18709. 2011 -
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism
Kansanen Emilia, Bonacci Gustavo, Schopfer Francisco J, Kuosmanen Suvi M, Tong Kit I, Leinonen Hanna, Woodcock Steven R, Yamamoto Masayuk, Carlberg Carsten, Ylä-Herttuala Seppo, Freeman Bruce A, Levonen Anna-Liisa. JOURNAL OF BIOLOGICAL CHEMISTRY 286: 14019-14027. 2011 -
Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
Karvinen H, Pasanen E, Rissanen T, Korpisalo P, Vähäkangas E, Jazwa A, Giacca M, Ylä-Herttuala S.. GENE THERAPY 18: 1166-1172. 2011 -
Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions
Kholová Ivana, Dragneva Galina, Cermáková Petra, Laidinen Svetlana, Kaskenpää Nina, Hazes Thierry, Cermáková Eva, Steiner Ivo, Ylä-Herttuala Seppo. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 41: 487-497. 2011 -
Vascular endothelial growth factors in retinal and choroidal neovascular diseases.
Kinnunen K, Ylä-Herttuala S. Annals of Medicine Posted online on February 1, 2011: --. 2011 -
Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy
Korpisalo P, Hytönen JP, Laitinen JT, Laidinen S, Parviainen H, Karvinen H, Siponen J, Marjomäki V, Vajanto I, Rissanen TT, Ylä-Herttuala S.. EUROPEAN HEART JOURNAL 32: 1664-1672. 2011 -
VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease
Krebs R, Tikkanen J, Ropponen JO, Jeltsch M, Jokinen JJ, Yla-Herttuala S,Koskinen PK, Nykanen AI, Lemstrom KB. JOURNAL OF HEART AND LUNG TRANSPLANTATION 30: 118-118. 2011 -
Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κ B, hypoxia-inducible factor-1A, and ETS transcription factors
Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE, Ylä-Herttuala S. 2011. Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors NEUROSURGERY 68 6: 1667- 2011 -
TAFFEL: Independent enrichment analysis of gene sets
Kurki Mitja I, Paananen Jussi, Storvik Markus, Ylä-Herttuala Seppo, Jääskeläinen Juha E, Fraunberg von und zu Mikael, Wong Garry, Pehkonen Petri. BMC BIOINFORMATICS [ONLINE] 12: 171. 2011 -
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
Leppänen Veli-Matti, Jeltsch Michael, Anisimov Andrey, Tvorogov Denis, Aho Kukka, Kalkkinen Nisse, Toivanen Pyry, Ylä-Herttuala Seppo, Ballmer-Hofer Kurt, Alitalo Kari. BLOOD 117: 1507-1515. 2011 -
Requirements for baculoviruses for clinical gene therapy applications
Lesch Hanna P, Makkonen Kaisa-Emilia, Laitinen Anna, Määttä Ann-Marie, Närvänen Outi, Airenne Kari J, Ylä-Herttuala Seppo. JOURNAL OF INVERTEBRATE PATHOLOGY 107: S106-S112. 2011 -
Production and purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors
Lesch HP, Laitinen A, Peixoto C, Vicente T, Makkonen KE, Laitinen L, Pikkarainen JT, Samaranayake H, Alves PM, Carrondo MJ, Ylä-Herttuala S, Airenne KJ. GENE THERAPY 18: 531-538. 2011 -
Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67: 269-277, 2012
Liimatainen T, Sierra A, Hanson T, Sorce DJ, Ylä-Herttuala S, Garwood M, Michaeli S, Gröhn O. 2011. Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field. Magn. Reson. Med. 67; 269-277, 2012 MAGNETIC RESONANCE IN MEDICINE 2012 Jan;67(1) Epub 2011 Jun 30: 269-277. 2011 -
Growth factor therapy and autologous lymph node transfer in lymphedema
Lähteenvuo Markku, Honkonen Krista, Tervala Tomi, Tammela Tuomas , Suominen Erkki, Lähteenvuo Johanna, Kholová Ivana, Alitalo Kari, Ylä-Herttuala Seppo, Saaristo Anne. CIRCULATION 123: 613-620. 2011 -
10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb.
Muona K, Mäkinen K, Hedman M, Manninen H, Ylä-Herttuala S. GENE THERAPY 2011 Jul 21.: --. 2011 -
Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells
Pulkkinen KH, Ylä-Herttuala S, Levonen AL. FREE RADICAL BIOLOGY & MEDICINE 2011 Dec 1;51(11): 2124-31. 2011 -
VEGFR-1 and -3 and angiopoietin receptor Tie2 targeted gene therapy prevents the growth of solid human ovarian cancer in mice compared to cotargeting Tie1 and Tie2
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Heikura T, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. CANCER GENE THERAPY 18 2: 100-9. 2011 -
Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats
Serpi Raisa, Tolonen Anna-Maria, Huusko Jenni, Rysä Jaana, Tenhunen Olli, Ylä-Herttuala Seppo, Ruskoaho Heikki. CARDIOVASCULAR RESEARCH 89: 204-213. 2011 -
Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques
Silvola J, Saraste A, Laitinen I, Nina Savisto N, Laine JO, Heinonen SE, Ylä-Herttuala S, Saukko P,Nuutila P, Roivainen A, Knuuti J. JACC: CARDIOVASCULAR IMAGING 2011; 4: 1294-1301. 2011 -
Uptake of 68gallium in atherosclerotic plaques in LDLR-/-ApoB100/100 mice
Silvola JM, Laitinen I, Sipilä HJ, Laine VJ, Leppänen P, Ylä-Herttuala S, Knuuti J, Roivainen A. EJNMMI research 2011, 1:14: --. 2011 -
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice
Silvola Johanna MU, Saraste Antti, Forsback Sarita, Laine V Jukka O, Saukko Pekka, Heinonen Suvi E, Ylä-Herttuala Seppo, Roivainen Anne, Knuuti Juhani. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 31: 1011-1015. 2011 -
Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis
Tammela Tuomas, Saaristo Anne, Holopainen Tanja, Ylä-Herttuala Seppo, Andersson Leif C, Virolainen Susanna, Immonen Ilkka, Alitalo Kari. SCIENCE TRANSLATIONAL MEDICINE 3: "-". 2011 -
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Tammela Tuomas, Zarkada Georgia, Nurmi Harri, Jakobsson Lars, Heinolainen Krista,Tvorogov Denis, Zheng Wei, Franco Caludio A, Murtomäki Aino, Aranda Evelyn, Miura Naoyuki ,Ylä-Herttuala Seppo, Fruttiger Marcus, Mäkinen Taija, Eichmann Anne, Pollard Jeffrey W, Gerhardt Holger, Alitalo Kari. NATURE CELL BIOLOGY 13: 1202-1213. 2011 -
Epigenetic regulation of key vascular genes and growth factors
Turunen Mikko P, Ylä-Herttuala Seppo. CARDIOVASCULAR RESEARCH 90: 441-446. 2011 -
Glioblastoma Multiforme: Use of Adenoviral Vectors
Wirth T, Samaranayake H, Ylä-Herttuala S. Hayat, MA, Tumors of the Central Nervous System, Volume 2. 335-347. 2011 -
Gene Therapy of Glioblastoma Multiforme - Clinical Experience on the Use of Adenoviral Vectors
Wirth T, Ylä-Herttuala S. Ana L. Abujamra, Brain Tumors - Current and Emerging Therapeutic Strategies. 403-422. 2011 -
Therapeutic delivery using gene-delivery methods
Ylä-Herttuala S, Wirth T. Therapeutic Delivery April 2011, Vol. 2, No. 4: 423-426. 2011 -
Stabilisation of atherosclerotic plaques
Ylä-Herttuala Seppo, Bentzon Jacob Fog, Daemen Mat, Falk Erling, Garcia-Garcia Hector M, Herrmann Joerg, Hoefer Imo, Jukema J. Wouter, Krams Rob, Kwak Brenda R, Marx Nikolaus, Naruszewicz Marek, Newby Andrew, Pasterkamp Gerard, Serruys Patrick WJC, Waltenberger Johannes, Weber Christian, Tokgözoglu Lale. THROMBOSIS AND HAEMOSTASIS 106: 1-19. 2011 -
Review focus on epigenetics and the histone code in vascular biology
Ylä-Herttuala Seppo, Glass Christopher K. CARDIOVASCULAR RESEARCH 90: 402-403. 2011 -
Gene therapy moves forward in 2010
Ylä-Herttuala Seppo. MOLECULAR THERAPY 19: 219-220. 2011 -
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. BLOOD 2011 Jul 28;118(4): 1154-62. 2011 -
In vivo application and tracking of baculovirus
Airenne KJ, Makkonen K-E, Mähönen AJ & Ylä-Herttuala S. CURRENT GENE THERAPY 10: 187-194. 2010 -
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P et al. CIRCULATION 122: 1725-1733. 2010 -
Relevance of an academic GMP Pan-European vector infra-structure (PEVI)
Cohen-Haguenauer O, Creff N, Cruz P, Tunc C, Aïuti A, Baum C, Bosch F, Blomberg P, Cichutek K & Collins M. CURRENT GENE THERAPY 10: 414-422. 2010 -
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, van Meeteren LA, Samen E, Lu L, Vanwildemeersch M et al. NATURE (LONDON) 464: 917-921. 2010 -
In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with 111In-labeled monoclonal antibodies.
Huhtala T, Laakkonen P, Sallinen H, Ylä-Herttuala S & Närvänen A. NUCLEAR MEDICINE AND BIOLOGY 37 8: 953-963. 2010 -
Geenihoito ja molekyylivirologian muut sovellukset
Hukkanen V, Hemminki A & Ylä-Herttuala S. , Mikrobiologia. 706-715. 2010 -
The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice
Huusko J, Merentie M, Dijkstra MH, Ryhänen M-M, Karvinen H, Rissanen TT, Vanwildemeersch M, Hedman M, Lipponen J, Heinonen SE et al. CARDIOVASCULAR RESEARCH 86: 122-130. 2010 -
Morphological characterization of baculovirus Autographa californica multiple nucleopolyhedrovirus
Ihalainen TO, Laakkonen JP, Paloheimo O, Ylä-Herttuala S, Airenne KJ & Vihinen-Ranta M. Virus Research 148: 71-74. 2010 -
Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice
Jazwa A, Kucharzewska P, Leja J, Zagorska A, Sierpniowska A, Stepniewski J, Kozakowska M, Taha H, Ochiya T, Derlacz R et al. Genetic Vaccines and Therapy 8: 1-16. 2010 -
Screening of complement inhibitors: shielded baculoviruses increase the safety and efficacy of gene delivery
Kaikkonen MU, Maatta AI, Ylä-Herttuala S & Airenne KJ. MOLECULAR THERAPY 18: 987-992. 2010 -
New aspects in vascular gene therapy
Karvinen H & Ylä-Herttuala S. CURRENT OPINION IN PHARMACOLOGY 2: 208-211. 2010 -
Sulforaphane inhibits endothelial lipase expression through NF-κ B in endothelial cells
Kivelä AM, Mäkinen PI, Jyrkkänen HK, Mella-Aho E, Xia Y, Kansanen E, Leinonen H, Verma IM, Ylä-Herttuala S & Levonen AL. 2010. Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. ATHEROSCLEROSIS 213: 122-128. 2010 -
Stimulation of functional vessel growth by gene therapy
Korpisalo P & Ylä-Herttuala S. Integrative Biology 2: 102-112. 2010 -
Uptake of 11C-choline in mouse atherosclerotic plaques
Laitinen IEK, Luoto P, Någren K, Marjamäki PM, Silvola JMU, Hellberg S, Laine VJO, Ylä-Herttuala S, Knuuti J & Roivainen A. JOURNAL OF NUCLEAR MEDICINE 51: 798-802. 2010 -
Avidin-biotin technology in targeted therapy
Lesch HP, Kaikkonen MU, Pikkarainen JT & Ylä-Herttuala S. EXPERT OPINION ON DRUG DELIVERY 7: 551-564. 2010 -
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver
Lämsä V, Levonen AL, Leinonen H, Ylä-Herttuala S, Yamamoto M & Hakkola J. CHEMICAL RESEARCH IN TOXICOLOGY 23: 977-985. 2010 -
Primary effect of 1α ,25(OH)(2)D(3) on IL-10 expression in monocytes is short-term down-regulation
Matilainen JM, Husso T, Toropainen S, Seuter S, Turunen MP, Gynther P, Ylä-Herttuala S, Carlberg C, Väisänen S.. 2010. Primary effect of 1α,25(OH)(2)D(3) on IL-10 expression in monocytes is short-term down-regulation. BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH 1803 11: 1276- 2010 -
Culture medium induced vimentin reorganization associates with enhanced baculovirus-mediated gene delivery
Mähönen AJ, Makkonen KE, Laakkonen JP, Ihalainen TO, Kukkonen SP, Kaikkonen MU, Vihinen-Ranta M, Ylä-Herttuala S & Airenne KJ. JOURNAL OF BIOTECHNOLOGY 145: 111-119. 2010 -
Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors
Mäkinen PI, Lappalainen JP, Heinonen SE, Leppänen P, Lähteenvuo MT, Aarnio JV, Heikkilä J, Turunen MP & Ylä-Herttuala S. CARDIOVASCULAR RESEARCH 88: 530-538. 2010 -
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B et al. EMBO JOURNAL 29: 1377-1388. 2010 -
Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S et al. CIRCULATION 121: 1413-1422. 2010 -
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits
Roy H, Bhardwaj S, Babu M, Lähteenvuo JE & Ylä-Herttuala S. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 40: 422-432. 2010 -
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K & Ylä-Herttuala S. CANCER GENE THERAPY 18 2: 100-109. 2010 -
Preoperative angiopoietin-2 serum levels. A marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer
Sallinen H, Heikura T, Laidinen S, Kosma V-M, Heinonen S, Ylä-Herttuala S & Anttila M. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 20 9: 1498-1505. 2010 -
Future prospects and challenges of antiangiogenic cancer gene therapy
Samaranayake H, Määttä AM, Pikkarainen J & Ylä-Herttuala S.. HUMAN GENE THERAPY 21: 381-396. 2010 -
Production of HIV-1 integrase fusion protein-carrying lentiviral vectors for gene therapy and protein transduction
Schenkwein D, Turkki V, Kärkkäinen HR, Airenne K & Ylä-Herttuala S. HUMAN GENE THERAPY 21: 589-602. 2010 -
Enhanced angiogenesis and reduced infarct size by vascular endothelial growth factor D is not translated to behavioral outcome in a rat model of ischemic stroke
Yanev P, Jolkkonen J, Airenne KJ, Ylä-Herttuala S & Wirth T. JOURNAL OF EXPERIMENTAL STROKE & TRANSLATIONAL MEDICINE 3: 1-12. 2010 -
Baculovirus-mediated gene transfer: An emerging universal concept
Airenne KJ, Mähönen AJ, Laitinen OH, Ylä-Herttuala S. Teoksessa: Templeton NS (toim.), Gene and Cell Therapy. Therapeutic Mechanisms and Stragegies.Taylor and Francis. ss. 263-291. 2009 -
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen V-M, Jeltsch M, Ylä-Herttuala S, Alitalo K. CIRCULATION RESEARCH 104: 1302-1312. 2009 -
(68)Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice
Haukkala J, Laitinen I, Luoto P, Iveson P, Wilson I, Karlsen H, Cuthbertson A, Laine J, Leppänen P, Ylä-Herttula S, Knuuti J, Roivainen A. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 36: 2058-2067. 2009 -
Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer
Hedman M, Muona K, Hedman A, Kivelä A, Syvänne M, Eränen J, Rantala A, Stjernvall J, Nieminen MS, Hartikainen J, Ylä-Herttuala S. GENE THERAPY 16: 629-634. 2009 -
(Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery
Kaikkonen MU, Lesch HP, Pikkarainen J, Räty JK, Vuorio T, Huhtala T, Taavitsainen M, Laitinen T, Tuunanen P, Gröhn O, Närvänen A, Airenne KJ, Ylä-Herttuala S. GENE THERAPY 16: 894-904. 2009 -
Extended release of adenovirus from silica implants in vitro and in vivo
Kangasniemi L, Koskinen M, Jokinen M, Toriseva M, Ala-Aho R, Kähäri V-M, Jalonen H, Ylä-Herttuala S, Moilanen H, Stenman U-H, Diaconu I, Kanerva A, Pesonen S, Hakkarainen T, Hemminki A. GENE THERAPY 16: 103-110. 2009 -
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 38: 16505-16510. 2009 -
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid
Kansanen E, Jyrkkänen H-K, Volger OL, Leinonen H, Kivelä AM, Häkkinen S-K, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen A-L. JOURNAL OF BIOLOGICAL CHEMISTRY 284 48: 33233-33241. 2009 -
PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries
Karvinen H, Rutanen J, Leppänen O, Lach R, Levonen A-L, Eriksson U, Ylä-Herttuala S. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 39 4: 320-327. 2009 -
Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye
Kinnunen K, Kalesnykas G, Mähönen AJ, Laidinen S, Holma L, Heikura T, Airenne K, Uusitalo H, Ylä-Herttuala S, Kinnunen K, Kalesnykas G. JOURNAL OF GENE MEDICINE 11: 382-389. 2009 -
Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes
Kinnunen K, Puustjärvi T, Teräsvirta M, Nurmenniemi P, Heikura T, Laidinen S, Paavonen T, Uusitalo H, Ylä-Herttuala S, Kinnunen K. BRITISH JOURNAL OF OPHTHALMOLOGY 93: 1109-1115. 2009 -
Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation
Kärkkäinen A-M, Kotimaa A, Huusko J, Kholova I, Heinonen SE, Stefanska A, Dijkstra MH, Purhonen H, Hämäläinen E, Mäkinen PI, Turunen MP, Ylä-Herttuala S. BLOOD 113: 4468-4475. 2009 -
A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells
Kärkkäinen H-R, Lesch HP, Määttä AI, Toivanen PI, Mähönen AJ, Roschier MM, Airenne KJ, Laitinen OH, Ylä-Herttuala S. BMC RESEARCH NOTES (ONLINE) 2: 63. 2009 -
Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells
Laakkonen JP, Mäkelä AR, Kakkonen E, Turkki P, Kukkonen S, Peränen J, Ylä-Herttuala S, Airenne KJ, Oker-Blom C, Vihinen-Ranta M, Marjomäki V. PLOS ONE [ONLINE] 4 4: e5093. 2009 -
Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus
Lahtinen L, Huusko N, Myöhänen H, Lehtivarjo AK, Pellinen R, Turunen MP, Ylä-Herttuala S, Pirinen E, Pitkänen A. NEUROSCIENCE 163: 316-328. 2009 -
Uptake of inflammatory cell marker [(11)C]PK11195 into mouse atherosclerotic plaques
Laitinen I, Marjamäki P, Någren K, Laine VJO, Wilson I, Leppänen P, Ylä-Herttuala S, Roivainen A, Knuuti J. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 36: 73-80. 2009 -
Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice
Laitinen I, Saraste A, Weidl E, Poethko T, Weber AW, Nekolla SG, Leppänen P, Ylä-Herttuala S, Hölzlwimmer G, Walch A, Esposito I, Wester H-J, Knuuti J, Schwaiger M. 2: 331-338. 2009 -
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro(R)) after intracerebral administration
Langford G, Dayan A, Yla-Herttuala S, Eckland D. JOURNAL OF GENE MEDICINE 11: 468-476. 2009 -
Avidin fusion protein-expressing lentiviral vector for targeted drug delivery
Lesch HP, Pikkarainen JT, Kaikkonen MU, Taavitsainen M, Samaranayake H, Lehtolainen-Dalkilic P, Vuorio T, Määttä A-M, Wirth T, Airenne KJ, Ylä-Herttuala S. HUMAN GENE THERAPY 20: 871-882. 2009 -
HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells
Loboda A, Stachurska A, Florczyk U, Rudnicka D, Jazwa A, Wegrzyn J, Kozakowska M, Stalinska K, Poellinger L, Levonen A-L, Yla-Herttuala S, Jozkowicz A, Dulak J. ANTIOXIDANTS AND REDOX SIGNALING 11: 1501-1517. 2009 -
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms
Lähteenvuo JE, Lähteenvuo MT, Kivelä A, Rosenlew C, Falkevall A, Klar J, Heikura T, Rissanen TT, Vähäkangas E, Korpisalo P, Enholm B, Carmeliet P, Alitalo K, Eriksson U, Ylä-Herttuala S. CIRCULATION 119: 845-856. 2009 -
Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma
Määttä AM, Samaranayake H, Pikkarainen J, Wirth T, Ylä-Herttuala S. CURRENT GENE THERAPY 9: 356-367. 2009 -
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. JOURNAL OF CELL BIOLOGY 185 3: 439-457. 2009 -
Molecular genetics of atherosclerosis
Roy H, Bhardwaj S, Yla-Herttuala S. HUMAN GENETICS 125: 467-491. 2009 -
Antiangiogenic gene therapy with soluble VEGFR-1, -2 and -3 reduces the growth of solid human ovarian carcinoma in mice
Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma V-M, Heinonen S, Alitalo K, Yla-Herttuala S. MOLECULAR THERAPY 17 2: 278-284. 2009 -
Challenges in monoclonal antibody-based therapies
Samaranayake H, Wirth T, Schenkwein D, Räty JK, Ylä-Herttuala S. Annals of Medicine 41 5: 322-331. 2009 -
VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Danese S. GASTROENTEROLOGY 136: 585-595. 2009 -
Novel vascular endothelial growth factor D variants with increased biological activity
Toivanen PI, Nieminen T, Viitanen L, Alitalo A, Roschier M, Jauhiainen S, Markkanen JE, Laitinen OH, Airenne TT, Salminen TA, Johnson MS, Airenne KJ, Ylä-Herttuala S. JOURNAL OF BIOLOGICAL CHEMISTRY 284 23: 16037-16048. 2009 -
Epigenetics and atherosclerosis
Turunen MP, Aavik E, Ylä-Herttuala S. BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS 1790: 886-891. 2009 -
Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy
Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, Glass CK, Väisänen S, Ylä-Herttuala S. Circulation research 105: 604-609. 2009 -
Antegrade flow and peripheral resistance determine the level of endogenous arteriogenesis in patients with superficial femoral artery occlusion
Vajanto I, Korpisalo P, Karjalainen J, Hakala T, Mäkinen K, Ylä-Herttuala S. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 39: 1048-1054. 2009 -
Intravitreal adenoviral 15-lipoxygenase- 1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes
Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. HUMAN GENE THERAPY 20: 1679-1686. 2009 -
Clinical trials for glioblastoma multiforme using adenoviral vectors
Wirth T, Samaranayake H, Pikkarainen J, Määttä A-M, Ylä-Herttuala S. CURRENT OPINION IN MOLECULAR THERAPEUTICS 11: 485-492. 2009 -
Geenihoito
Ylä-Herttuala S. DUODECIM 125: 1729-1739. 2009 -
Gene therapy with vascular endothelial growth factors
Ylä-Herttuala S. BIOCHEMICAL SOCIETY TRANSACTIONS 37: 1198-1200. 2009 -
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Zhang F, Tang Z, Hou X, Lennartsson J , Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong G-H, Ding H, Greenberg DA, Becker KG, Herbert J-M. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 15: 6152-6157. 2009 -
Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits
Aggarwal NT, Chawengsub Y, Gauthier KM, Viita H, Yla-Herttuala S, Campbell WB. HYPERTENSION 51: 246-251. 2008 -
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
Benest AV, Harper SJ, Yla Herttuala S, Alitalo K, Bates DO. CARDIOVASCULAR RESEARCH 78: 315-323. 2008 -
Gene therapy to prevent occlusion of venous bypass grafts
Bhardwaj S, Roy H, Ylä-Herttuala S. EXPERT REVIEW OF CARDIOVASCULAR THERAPY 6 5: 641-652. 2008 -
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice
Botusan IR, Sunkari VG, Savu O, Catrina AI, Grünler J, Lindberg S, Pereira T, Ylä-Herttuala S, Poellinger L, Brismar K, Catrina SB. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 49: 19426-19431. 2008 -
Experimental hyperlipidaemia does not prevent preconditioning and it reduces ischemia-induced apoptosis
Dworakowski R, Dworakowska D, Kocic I, Wirth T, Gruchala M, Kaminski M, Ray R, Petrusewicz J, Yla-Herttuala S, Rynkiewicz A. INTERNATIONAL JOURNAL OF CARDIOLOGY 126: 62-67. 2008 -
KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells
Fledderus JO, Boon RA, Volger OL, Hurttila H, Ylä-Herttuala S, Pannekoek H, Levonen A-L, Horrevoets AJG. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 28: 1339-1346. 2008 -
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K. CANCER RESEARCH 68: 4754-4762. 2008 -
Oxidative stress-inducible lentiviral vectors for gene therapy
Hurttila H, Koponen JK, Kansanen E, Jyrkkänen H-K, Kivelä A, Kylätie R, Ylä-Herttuala S, Levonen A-L. GENE THERAPY 15: 1271-1279. 2008 -
Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques
Huusko J, Mäkinen PI, Alhonen L, Ylä-Herttuala S. Latterich M, RNAi.Taylor & Francis. 91-111. 2008 -
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, Goldsteins G, Jauhiainen S, Tiainen S, Makkonen H, Oskolkova O, Afonyushkin T, Koistinaho J, Yamamoto M, Bochkov VN, Ylä-Herttuala S, Levonen A-L. CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 103: e1-e9. 2008 -
Targeting and purification of metabolically biotinylated baculovirus
Kaikkonen MU, Viholainen JI, Närvänen A, Ylä-Herttuala S, Airenne KJ. HUMAN GENE THERAPY 19 6: 589-600. 2008 -
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 39 3: 302-313. 2008 -
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K. CIRCULATION RESEARCH 103: 1018-1026. 2008 -
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia
Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U. DEVELOPMENTAL BIOLOGY 332: 33-45. 2008 -
Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells
Kivelä AM, Kansanen E, Jyrkkänen HK, Nurmi T, Ylä-Herttuala S, Levonen AL. JOURNAL OF NUTRITION 138: 1263-1268. 2008 -
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic
Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S. CIRCULATION RESEARCH 103: 1092-1099. 2008 -
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs
Korpisalo P, Rissanen TT, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, Markkanen JE, Gröhn OH, Ylä-Herttuala S. CARDIOVASCULAR RESEARCH 80 2: 263-270. 2008 -
Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells
Laakkonen JP, Kaikkonen MU, Ronkainen PHA, Ihalainen TO, Niskanen EA, Häkkinen M, Salminen M, Kulomaa MS, Ylä-Herttuala S, Airenne KJ, Vihinen-Ranta M. CELLULAR MICROBIOLOGY 10 3: 667-681. 2008 -
The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring
Laurema A, Riekkinen M, Heikura T, Vähäkangas E, Manninen H, Heinonen S, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 10: 1005-1011. 2008 -
Generation of lentivirus vectors using recombinant baculoviruses
Lesch HP, Turpeinen S, Niskanen EA, Mähönen AJ, Airenne KJ, Ylä-Herttuala S. GENE THERAPY 15: 1280-1286. 2008 -
Antioxidant gene therapy for cardiovascular disease: current status and future perspectives
Levonen A-L, Vähäkangas E, Koponen JK, Ylä-Herttuala S. CIRCULATION 117: 2142-2150. 2008 -
1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo
Liimatainen TJ, Erkkilä AT, Valonen P, Vidgren H, Lakso M, Wong G, Gröhn OHJ, Ylä-Herttuala S, Hakumäki JM. MAGNETIC RESONANCE IN MEDICINE 59: 1232-1238. 2008 -
Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetes
Odermarsky M, Andersson S, Pesonen E, Sjöblad S, Ylä-Herttuala S, Liuba P. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 38 6: 381-388. 2008 -
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210
Pulkkinen K, Malm T, Turunen M, Koistinaho J, Ylä-Herttuala S. FEBS LETTERS 582: 2397-2401. 2008 -
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
Purhonen S, Palm J, Rossi D, Kaskenpää N, Rajantie I, Ylä-Herttuala S, Alitalo K, Weissman IL, Salven P. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 18: 6620-6625. 2008 -
High-resolution ultrasound perfusion imaging of therapeutic angiogenesis
Rissanen TT, Korpisalo P, Karvinen H, Liimatainen T, Laidinen S, Gröhn OH, Ylä-Herttuala S. JACC: CARDIOVASCULAR IMAGING 1 1: 83 - 91. 2008 -
Improving safety of gene therapy
Räty JK, Lesch HP, Wirth T, Ylä-Herttuala S. CURRENT DRUG SAFETY 3 1: 46-53. 2008 -
Severe coronary artery stenoses and reduced coronary flow velocity reserve in atherosclerotic mouse model Doppler echocardiography validation study
Saraste A, Kytö V, Laitinen I, Saraste M, Leppänen P, Ylä-Herttuala S, Saukko P, Hartiala J, Knuuti J. ATHEROSCLEROSIS 200: 89-94. 2008 -
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho
Sierra A, Michaeli S, Niskanen J-P, Valonen PK, Gröhn HI, Ylä-Herttuala S, Garwood M, Gröhn OH. MAGNETIC RESONANCE IN MEDICINE 59: 1311-1319. 2008 -
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela T , Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M , Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G., Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C. NATURE (LONDON) 454: 656-660. 2008 -
Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2
Tuomisto TT, Lumivuori H, Kansanen E, Häkkinen S-K, Turunen MP, van Thienen JV, Horrevoets AJ, Levonen A-L, Ylä-Herttuala S. CARDIOVASCULAR RESEARCH 78 1: 175-184. 2008 -
15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expression
Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, Heikura T, Turpeinen S, Laidinen S, Takalo T, Ylä-Herttuala S. CIRCULATION RESEARCH 102: 177-184. 2008 -
Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation
Aggarwal NT, Holmes BB, Cui L, Viita H, Yla-Herttuala S, Campbell WB. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 292: H1033-H1041. 2007 -
Safe, simple, and high-capacity gene delivery into insect and vertebrate cells by recombinant baculoviruses
Airenne KJ, Laitinen OH, Mähönen AJ. Friedmann T, Rossi J, Gene Transfer. Delivery and Expression of DNA and RNA. A Laboratory Manual.Gold Spring Harbor. 313-325. 2007 -
Solusiirrot sydämen vajaatoiminnan hoidossa
Back J, Kankuri E, Ikonen T, Pätilä T, Sinisalo J, Laine M, Vapaatalo H, Koponen J, Hukkanen M, Ylä-Herttuala S, Alitalo R, Kupari M, Harjula A. DUODECIM 123: 398-405. 2007 -
Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta
Bräsen JH, Leppänen O, Inkala M, Heikura T, Levin M, Ahrens F, Rutanen J, Pietsch H, Bergqvist D, Levonen A-L, Basu S, Zeller T, Klöppel G, Laukkanen MO, Ylä-Herttuala S. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 50 23: 2249-2253. 2007 -
Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia
Heinonen SE, Leppänen P, Kholová I, Lumivuori H, Häkkinen S-K, Bosch F, Laakso M, Ylä-Herttuala S, Kholova I, Laakso M. CIRCULATION RESEARCH 101: 1058-1067. 2007 -
Rhizavidin from Rhizobium etli: the first natural dimer in the avidin protein family
Helppolainen SH, Nurminen KP, Määttä JAE, Halling KK, Slotte JP, Huhtala T, Liimatainen T, Ylä-Herttuala S, Airenne KJ, Närvänen A, Jänis J, Vainiotalo P, Valjakka J, Kulomaa MS, Nordlund HR. BIOCHEMICAL JOURNAL 405: 397-405. 2007 -
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein
Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, Yla-Herttuala S, Alitalo K. CIRCULATION RESEARCH 100 10: 1460-1467. 2007 -
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma
Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OHJ. RADIOLOGY 243: 796-803. 2007 -
Adenovirus-mediated gene transfer of human vascular endothelial growth factor-d induces transient angiogenic effects in mouse hind limb muscle
Kholová I, Koota S, Kaskenpää N, Leppänen P, Närväinen J, Kavec M, Rissanen TT, Hazes T, Korpisalo P, Gröhn O, Ylä-Herttuala S. HUMAN GENE THERAPY 18: 232-244. 2007 -
Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model
Koponen JK, Kekarainen T, Heinonen SE, Laitinen A, Nystedt J, Laine J, Ylä-Herttuala S. MOLECULAR THERAPY 15 12: 2172-2177. 2007 -
The strengths and weaknesses of VEGF adenovirus-driven angiogenesis
Korpisalo P, Rissanen TT, Ylä-Herttuala S. Deindl E, Kupatt C, Therapeutic Neovascularization - Quo Vadis?.Springer. 23-32. 2007 -
Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle
Laurema A, Lumme S, Heinonen SE, Heinonen S, Ylä-Herttuala S. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 86 9: 1035-1040. 2007 -
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo
Levonen A-L, Inkala M, Heikura T, Jauhiainen S, Jyrkkänen H-K, Kansanen E, Määttä K, Romppanen E, Turunen P, Rutanen J, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 27: 741-747. 2007 -
Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination
Liuba P, Aburawi EH, Pesonen E, Andersson S, Truedsson L, Ylä-Herttuala S, Holmberg L. Annals of Medicine 39 5: 392-399. 2007 -
Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment
Lucerna M, Zernecke A, de Nooijer R, de Jager SC, Bot I, van der Lans C, Kholova I, Liehn EA, van Berkel TJC, Yla-Herttuala S, Weber C, Biessen EAL. BLOOD 109 1: 122-129. 2007 -
Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells
Mähönen AJ, Airenne KJ, Purola S, Peltomaa E, Kaikkonen MU, Riekkinen MS, Heikura T, Kinnunen K, Roschier MM, Wirth T, Ylä-Herttuala S. JOURNAL OF BIOTECHNOLOGY 131 1: 1-8. 2007 -
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. MOLECULAR AND CELLULAR BIOLOGY 27 13: 4953-4967. 2007 -
Current status of cardiovascular gene therapy
Rissanen TT, Ylä-Herttuala S. MOLECULAR THERAPY 15 7: 1233-1247. 2007 -
Uudisverisuonten kasvattaminen - kohti iskeemisten kudosten parempaa verenkiertoa
Rissanen TT, Ylä-Herttuala S. DUODECIM 123: 306-316. 2007 -
SPECT/CT imaging of baculovirus biodistribution in rat
Räty JK, Liimatainen T, Huhtala T, Kaikkonen MU, Airenne KJ, Hakumäki JM, Närvänen A, Ylä-Herttuala S. GENE THERAPY 14: 930-938. 2007 -
Non-invasive imaging in gene therapy
Räty JK, Liimatainen T, Kaikkonen MU, Gröhn O, Airenne KJ, Ylä-Herttuala S. MOLECULAR THERAPY 15 9: 1579-1586. 2007 -
Endostatin inhibits endochondral ossification
Sipola A, Ilvesaro J, Birr E, Jalovaara P, Pettersson RF, Stenbäck F, Ylä-Herttuala S, Hautala T, Tuukkanen J. JOURNAL OF GENE MEDICINE 9 12: 1057-1064. 2007 -
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins
Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K. CIRCULATION RESEARCH 100 10: 1468-1475. 2007 -
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. NATURE MEDICINE 13: 1458-1466. 2007 -
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Ylä-Herttuala S, Shibuya M, Alitalo K. JOURNAL OF EXPERIMENTAL MEDICINE 204 6: 1431-1440. 2007 -
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis
Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, Ylä-Herttuala S, Jauhiainen M, Olkkonen VM. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 27: 1108-1114. 2007 -
On the relationship of LDL and VEGFR1: not just a family affair
Ylä-Herttuala S, Alitalo K. EMBO REPORTS 8 12: 1127-1128. 2007 -
Vascular endothelial growth factors. Biology and current status of clinical applications in cardiovascular medicine
Ylä-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 49 10: 1015-1026. 2007 -
Peripheral vascular diseases. In Review: Progress and prospects: gene therapy clinical trials (Part 1)
Ylä-Herttuala S. GENE THERAPY 14: 1445-1447. 2007 -
Principles of gene medicines
Ylä-Herttuala S. EJHP PRACTICE JOURNAL [HTTP://WWW.EAHPONLINE.COM/] 13 5: 18-19. 2007 -
Adventitial VEGF(165) gene transfer prevents lumen loss through induction of positive arterial remodeling after PTCA in porcine coronary arteries
Deiner C, Schwimmbeck PL, Koehler IS, Loddenkemper C, Noutsias M, Nikol S, Schultheiss H-P, Ylä-Herttuala S, Pels K. ATHEROSCLEROSIS 189 1: 123-132. 2006 -
Gene therapy for cardiovascular diseases
Gruchala M, Roy H, Bhardwaj S, Ylä-Herttuala S. ur-Rahman A, Reitz AB, Frontiers in Medicinal Chemistry.Betham Science. 59-85. 2006 -
New technologies in cardiovascular research gene therapy
Hedman M, Turunen MP, Ylä-Herttuala S. Teoksessa: Pasterkamp G, de Kleijn DPV (toim.) Cardiovascular Research. New Technologies, Methods, and Applications. Ei jufo-kustantaja/not jufo publisher. s. 85-101. 2006 -
Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo
Kaikkonen MU, Räty JK, Airenne KJ, Wirth T, Heikura T, Ylä-Herttuala S. GENE THERAPY 13: 304-312. 2006 -
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation
Karpanen T, Wirzenius M, Mäkinen T, Veikkola T, Haisma HJ, Achen MG, Stacker SA, Pytowski B, Ylä-Herttuala S, Alitalo K. AMERICAN JOURNAL OF PATHOLOGY 169: 708-718. 2006 -
Overexpression of VEGF-A induces neovascularization and increased vascular leakage in rabbit eye after intravitreal adenoviral gene transfer
Kinnunen K, Korpisalo P, Rissanen TT, Heikura T, Viita H, Uusitalo H, Ylä-Herttuala S. ACTA PHYSIOLOGICA (OXFORD) 187: 447-457. 2006 -
Non-specific binding of [(18)F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries
Laitinen I, Marjamäki P, Haaparanta M, Savisto N, Laine VJO, Soini SL, Wilson I, Leppänen P, Ylä-Herttuala S, Roivainen A, Knuuti J. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 33 12: 1461-1467. 2006 -
Short and long-term effects of hVEGF-A165 in Cre-activated transgenic mice
Leppänen P, Kholová I, Mähönen AJ, Airenne K, Koota S, Mansukoski H, Närväinen J, Wirzenius M, Alhonen L, Jänne J, Alitalo K, Ylä-Herttuala S. PLOS ONE [ONLINE] 1 e13. 2006 -
Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain
Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006 -
Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro
Mäntylä T, Hakumäki JM, Huhtala T, Närvänen A, Ylä-Herttuala S. MAGNETIC RESONANCE IN MEDICINE 55 4: 800-804. 2006 -
Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alfa in healthy humans
Nälsén C, Vessby B, Berglund L, Uusitupa M, Hermansen K, Riccardi G, Rivellese A, Storlien L, Erkkilä A, Ylä-Herttuala S, Tapsell L, Basu S. JOURNAL OF NUTRITION 136: 1222-1228. 2006 -
Adenovirus-mediated HSV-tk gene therapy for malignant glioma: Clinical experience
Pulkkanen KJ, Yla-Herttuala S. Lowenstein PR, Castro MG, Gene Therapy for Neurological Disorders.Taylor and Francis. 327-341. 2006 -
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia
Pätilä T, Ikonen T, Rutanen J, Ahonen A, Lommi J, Lappalainen K, Krogerus L, Ihlberg L, Partanen TA, Lähteenoja L, Virtanen K, Alitalo K, Ylä-Herttuala S, Harjula A. JOURNAL OF HEART AND LUNG TRANSPLANTATION 25 2: 206-213. 2006 -
Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines
Rautsi O, Lehmusvaara S, Salonen T, Häkkinen K, Sillanpää M, Hakkarainen T, Heikkinen S, Vähäkangas E, Ylä-Herttuala S, Hinkkanen A, Julkunen I, Wahlfors J, Pellinen R. JOURNAL OF GENE MEDICINE 9 2: 122-135. 2006 -
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits [FJ Express Full-Length Article]
Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig K-H, Ylä-Herttuala S. FASEB JOURNAL [ONLINE] 20: E1550-E1559. 2006 -
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits
Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumäki J, Laakso M, Herzig K-H, Ylä-Herttuala S. FASEB JOURNAL 20: 2159-2161. 2006 -
Biology of vascular endothelial growth factors
Roy H, Bhardwaj S, Ylä-Herttuala S. FEBS LETTERS 580 12: 2879-2887. 2006 -
Magnetic resonance imaging of viral particle biodistribution in vivo
Räty JK, Liimatainen T, Wirth T, Airenne KJ, Ihalainen TO, Huhtala T, Hamerlynck E, Vihinen-Ranta M, Närvänen A, Ylä-Herttuala S, Hakumäki JM. GENE THERAPY 13: 1440-1446. 2006 -
Vascular endothelial growth factor-C accelerates diabetic wound healing
Saaristo A, Tammela T, Färkkilä A, Kärkkäinen M, Suominen E, Ylä-Herttuala S, Alitalo K. AMERICAN JOURNAL OF PATHOLOGY 169: 1080-1087. 2006 -
A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up
Sallinen H, Anttila M, Narvainen J, Ordén M-R, Ropponen K, Kosma V-M, Heinonen S, Yla-Herttuala S. GYNECOLOGIC ONCOLOGY 103 1: 315-320. 2006 -
Extracellular superoxide dismutase with vaccinia virus anti-inflammatory protein 35K or tissue inhibitor of metalloproteinase-1: Combination gene therapy in the treatment of vein graft stenosis in rabbits
Turunen P, Puhakka HL, Heikura T, Romppanen E, Inkala M, Leppänen O, Ylä-Herttuala S. HUMAN GENE THERAPY 17 4: 405-414. 2006 -
Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy
Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M, Ylä-Herttuala S. CURRENT DRUG SAFETY 1: 253-257. 2006 -
Gene technology based therapies in the brain
Wirth T, Ylä-Herttuala S. Teoksessa: Pickard JD (toim.). Springer. Advances and Technical Standards in Neurosurgery. s. 3-32. 2006 -
Periytyvien tautien hoito
Ylä-Herttuala S, Salo M. Aula P, Kääriäinen H, Palotie A, Perinnöllisyyslääketiede. 3. uud. p..Duodecim. 317-328. 2006 -
An update on angiogenic gene therapy: Vascular endothelial growth factor and other directions
Ylä-Herttuala S. CURRENT OPINION IN MOLECULAR THERAPEUTICS 8 4: 295-300. 2006 -
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM. JOURNAL OF CLINICAL INVESTIGATION 115: 247-257. 2005 -
VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries
Bhardwaj S, Roy H, Heikura T, Ylä-Herttuala S. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 35 11: 669-676. 2005 -
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries
Bhardwaj S, Roy H, Kärpänen T, Hi Y, Jauhiainen S, Hedman M, Alitalo K, Ylä-Herttuala S. GENE THERAPY 12 5: 388-394. 2005 -
Localization of M2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods
Chaudhuri JD, Hiltunen M, Nykänen M, Ylä-Herttuala S, Soininen H, Miettinen R, Hiltunen M, Soininen H. NEUROSCIENCE 131: 557-566. 2005 -
Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21(WAF1/CIP1) protein expression
Dworakowska D, Jassem E, Jassem J, Karmolinski A, Dworakowski R, Wirth T, Gruchala M, Rynkiewicz A, Skokowski J, Yla-Herttuala S, Jaskiewicz K, Czestochowska E. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 131 9: 617-623. 2005 -
Antibodies against oxidized LDL and cardiolipin and mortality in patients with coronary heart disease
Erkkilä AT, Närvänen O, Lehto S, Uusitupa MIJ, Ylä-Herttuala S. ATHEROSCLEROSIS 183: 157-162. 2005 -
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. CANCER RESEARCH 65: 4739-4746. 2005 -
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - an array study on casespecific human preeclamptic placental tissue
Heikkilä A, Tuomisto T, Häkkinen S-K, Keski-Nisula L, Heinonen S, Ylä-Herttuala S. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 84: 679-689. 2005 -
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone
Katsube K, Bishop AT, Simari RD, Ylä-Herttuala S, Friedrich PF. JOURNAL OF ORTHOPAEDIC RESEARCH 23 2: 469-474. 2005 -
Miten saada sydänlihasarpi sykkimään?
Koponen JK, Ylä-Herttuala S. DUODECIM 121: 1199-1201. 2005 -
Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis
Krebs R, Tikkanen MJ, Nykänen AI, Wood J, Jeltsch M, Ylä-Herttuala S, Koskinen PK, Lemström KB. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 171: 1421-1429. 2005 -
A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo
Laitinen OH, Airenne KJ, Hytönen VP, Peltomaa E, Mähönen AJ, Wirth T, Lind MM, Mäkelä KA, Toivanen PI, Schenkwein D, Heikura T, Nordlund HR, Kulomaa MS, Ylä-Herttuala S. NUCLEIC ACIDS RESEARCH 33 4: e42. 2005 -
Avidin fusion protein strategies in targeted drug and gene delivery
Laitinen OH, Airenne KJ, Räty JK, Wirth T, Ylä-Herttuala S. LETTERS IN DRUG DESIGN & DISCOVERY 2: 124-132. 2005 -
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic
Leppänen P, Koota S, Kholová I, Koponen J, Fieber C, Eriksson U, Alitalo K, Ylä-Herttuala S. CIRCULATION 112: 1347-1352. 2005 -
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease
Luoma JS, Kareinen A, Närvänen O, Viitanen L, Laakso M, Ylä-Herttuala S. FREE RADICAL BIOLOGY & MEDICINE 39: 1660-1665. 2005 -
Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart - gene therapy
Markkanen JE, Rissanen TT, Kivelä A, Ylä-Herttuala S. CARDIOVASCULAR RESEARCH 65 3: 656-664. 2005 -
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer
Pajusola K, Künnapuu J, Vuorikoski S, Soronen J, André H, Pereira T, Korpisalo P, Ylä-Herttuala S, Poellinger L, Alitalo K. FASEB JOURNAL 19 10: 1365-1367. 2005 -
Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits
Puhakka HL, Turunen P, Gruchala M, Bursill C, Heikura T, Vajanto I, Greaves DR, Channon K, Ylä-Herttuala S. IN VIVO (ATHENS) 19: 515-522. 2005 -
Tissue inhibitor of metalloproteinase 1 adenoviral gene therapy alone is equally effective in reducing restenosis as combination gene therapy in a rabbit restenosis model
Puhakka HL, Turunen P, Rutanen J, Hiltunen MO, Turunen MP, Ylä-Herttuala S. JOURNAL OF VASCULAR RESEARCH 42 5: 361-367. 2005 -
Gene therapy for malignant glioma: current clinical status
Pulkkanen KJ, Ylä-Herttuala S. MOLECULAR THERAPY 12 4: 585-598. 2005 -
Vascular oligonucleotide transfer facilitated by a polymer-coated stent
Radke PW, Griesenbach U, Kivela A, Vick T, Judd D, Munkonge F, Willis S, Geddes DM, Yla-Herttuala S, Alton EWFW. HUMAN GENE THERAPY 16 6: 734-740. 2005 -
Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis
Rissanen TT, Korpisalo P, Markkanen JE, Liimatainen T, Ordén M-R, Kholová I, de Goede A, Heikura T, Gröhn OH, Ylä-Herttuala S. CIRCULATION 112: 3937-3946. 2005 -
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A
Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig K-H, Bellu AR, Haisma HJ, Carmeliet P, Alitalo K, Ylä-Herttuala S. HUMAN GENE THERAPY 16 12: 1422-1428. 2005 -
Nonviral gene delivery methods in cardiovascular diseases
Ruponen M, Hyvönen Z, Urtti A, Ylä-Herttuala S. Fennell JP, Baker AH, Hypertension. Methods and Protocols.Humana Press. Methods in Molecular Medicine. 315-328. 2005 -
Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism
Rutanen J, Turunen A-M, Teittinen M, Rissanen TT, Heikura T, Koponen JK, Gruchala M, Inkala M, Jauhiainen S, Hiltunen MO, Turunen MP, Stacker SA, Achen MG, Ylä-Herttuala S. GENE THERAPY 12: 980-987. 2005 -
Gene transfer as a tool to induce therapeutic vascular growth in plastic surgery
Saaristo A, Suominen E, Yla-Herttuala S. HANDCHIRURGIE, MIKROCHIRURGIE, PLASTISCHE CHIRURGIE 37: 375-382. 2005 -
Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules
Salminen M, Airenne KJ, Rinnankoski R, Reimari J, Välilehto O, Rinne J, Suikkanen S, Kukkonen S, Ylä-Herttuala S, Kulomaa MS, Vihinen-Ranta M. JOURNAL OF VIROLOGY 79 5: 2720-2728. 2005 -
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmén C, Oike Y, Pajusola K, Thurston G, Suda T, Yla-Herttuala S, Alitalo K. BLOOD 105 2: 4642-4648. 2005 -
Genetics, genomics and proteomics in atherosclerosis research
Tuomisto TT, Binder BR, Ylä-Herttuala S. Annals of Medicine 37 5: 323-332. 2005 -
Analysis of gene and protein expression during monocyte-macrophage differentation and cholesterol loading - cDNA and protein array study
Tuomisto TT, Riekkinen MS, Viita H, Levonen A-L, Ylä-Herttuala S. ATHEROSCLEROSIS 180 2: 283-291. 2005 -
What have we learnt about microarray analyses of atherogenesis?
Tuomisto TT, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 16: 201-205. 2005 -
Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta
Turunen P, Puhakka H, Rutanen J, Hiltunen MO, Heikura T, Gruchala M, Ylä-Herttuala S. ATHEROSCLEROSIS 179 1: 27-33. 2005 -
Gene therapy of atherosclerosis
Vähäkangas E, Ylä-Herttuala S. Starke K, Handbook of Experimental Pharmacology.Springer. 785-807. 2005 -
Human gene therapy and imaging: cardiology
Wu JC, Ylä-Herttuala S. 32: S346-S357. 2005 -
Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes
Aburawi E, Liuba P, Pesonen E, Ylä-Herttuala S, Sjöblad S. DIABETES CARE 27: 2733-2735. 2004 -
Baculovirus-mediated gene transfer: An evolving new concept
Airenne KJ, Mähönen AJ, Laitinen OH, Ylä-Herttuala S. Teoksessa: Templeton NS (toim.), Gene and Cell Therapy.Marcel Dekker. ss. 181-197. 2004 -
Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells
Banning A, Schnurr K, Böl G-F, Kupper D, Müller-Schmehl K, Viita H, Ylä-Herttuala S, Brigelius-Flohe R. FREE RADICAL BIOLOGY & MEDICINE 36 2: 135-144. 2004 -
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors
Gruchala M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholová I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Büeler H, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 6 5: 545-554. 2004 -
Gene therapy for cardiovascular diseases
Gruchala M, Roy H, Bhardwaj S, Ylä-Herttuala S. CURRENT PHARMACEUTICAL DESIGN 10: 407-423. 2004 -
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli
Hytönen VP, Laitinen OH, Airenne TT, Kidron H, Meltola NJ, Porkka EJ, Hörhä J, Paldanius T, Määttä JAE, Nordlund HR, Johnson MS, Salminen TA, Airenne KJ, Ylä-Herttuala S, Kulomaa MS. BIOCHEMICAL JOURNAL 384: 385-390. 2004 -
AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled stydy
Immonen A, Vapalahti M, Tyynelä K, Hurskainen H, Sandmair A, Vanninen R, Langford G, Murray N, Ylä-Herttuala S. MOLECULAR THERAPY 10 5: 967-972. 2004 -
Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vasvular smooth muscle cells
Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppänen P, Turunen A-M, Ylä-Herttuala S. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36 3: 333-341. 2004 -
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy
Kankkonen HM, Vähäkangas E, Marr RA, Pakkanen T, Laurema A, Leppänen P, Jalkanen J, Verma IM, Ylä-Herttuala S. MOLECULAR THERAPY 9 4: 548-556. 2004 -
Angiogenesis-dependent and independent phases of intimal hyperplasia
Khurana T, Zhuang Z, Bhardwaj S, Murakami M, De Muinck E, Yla-Herttuala S, Ferrara N, Martin JF, Zachary I, Simons M. CIRCULATION 110: 2436-2443. 2004 -
Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1)
Koskinen K, Vainio PJ, Smith DJ, Pihlavisto M, Ylä-Herttuala S, Jalkanen S, Salmi M. BLOOD 103 9: 3388-3395. 2004 -
Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat features does not affect cells in the fetus
Laurema A, Vanamo K, Heikkilä AL, Riekkinen M, Heinonen S, Ylä-Herttuala S. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 190 1: 264-267. 2004 -
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits
Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin C-H, Östman A, Ylä-Herttuala S. CIRCULATION 109: 1140-1146. 2004 -
Optimized self-excising Cre-expression cassette for mammalian cells
Mähönen AJ, Airenne KJ, Lind MM, Lesch HP, Ylä-Herttuala S. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320 2: 366-371. 2004 -
Defective valves and abnormal mural cell recruitment underline lymphatic vascular failure in lymphedema distichiasis
Petrova TV, Karpanen T, Norrmén C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Ylä-Herttuala S, Miura N, Alitalo K. NATURE MEDICINE 10: 974-981. 2004 -
Cancer gene therapy - current status in the clinics
Pulkkanen KJ, Sallinen H, Tyynelä K, Yla-Herttuala S. GENE THERAPY AND REGULATION 2 3: 219-274. 2004 -
Gene transfer for therapeutic vascular growth in myocardial and peripheral ischemia
Rissanen TT, Rutanen J, Ylä-Herttuala S. ADVANCES IN GENETICS 52: 117-164. 2004 -
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart
Rutanen J, Rissanen TT, Markkanen JE, Gruchala M, Silvennoinen P, Kivelä A, Hedman A, Hedman M, Heikura T, Ordén M-R, Stacker SA, Achen MG, Hartikainen J, Ylä-Herttuala S.. CIRCULATION 109: 1029-1035. 2004 -
Transmyocardial angiogenic effects after intramyocardial adenoviral catheter-mediated VEGF-A and VEGF-D gene transfer in the porcine heart
Rutanen J, Rissanen TT, Markkanen JE, Ylä-Herttuala S. NOGA LETTER 3: 13-15. 2004 -
Enhanced gene delivery by avidin-displaying baculovirus
Räty JK, Airenne KJ, Marttila AT, Marjomäki V, Hytönen VP, Lehtolainen P, Laitinen OH, Mähönen AJ, Kulomaa MS, Ylä-Herttuala S. MOLECULAR THERAPY 9 2: 282-291. 2004 -
Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds
Saaristo A, Tammela T, Timonen J, Yla-Herttuala S, Tukiainen E, Asko-Seljavaara S, Alitalo K. FASEB JOURNAL 18: 1707-1709. 2004 -
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p
Tuhkanen H, Anttila M, Kosma V-M, Ylä-Herttuala S, Heinonen S, Kuronen A, Juhola M, Tammi R, Tammi M, Mannermaa A. INTERNATIONAL JOURNAL OF CANCER 109 2: 247-252. 2004 -
HIF-VEGF-VEGFR-2, TNF-alfa and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array
Tuomisto TT, Rissanen TT, Vajanto I, Korkeela A, Rutanen J, Ylä-Herttuala S. ATHEROSCLEROSIS 174: 111-120. 2004 -
Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro
Turunen P, Jalkanen J, Heikura T, Puhakka H, Karppi J, Nyyssönen K, Ylä-Herttuala S. JOURNAL OF LIPID RESEARCH 45: 1633-1639. 2004 -
Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density
Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Gröhn OHJ, Ylä-Herttuala S, Kauppinen RA. JOURNAL OF MAGNETIC RESONANCE IMAGING 19 4: 389-396. 2004 -
Introduction
Ylä-Herttuala S, Dzau VJ. EUROPEAN HEART JOURNAL. SUPPLEMENTS 6: E1. 2004 -
Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials
Ylä-Herttuala S, Markkanen JE, Rissanen TT. TRENDS IN CARDIOVASCULAR MEDICINE 14: 295-300. 2004 -
Therapeutic angiogenesis
Ylä-Herttuala S. Matsuzawa Y, Kita T, Nagai R, Teramoto T, Atherosclerosis XIII. Proceedings of the 13th International Atherosclerosis Symposium.Elsevier. International Congress Series. 15 - 18. 2004 -
Viral vs. non-viral vectors for myocardial angiogenesis
Ylä-Herttuala S. NOGA LETTER 3: 11-12. 2004 -
A New Class of Biological Agents. The Design, Development and Testing of Ad5FGF-4 to Treat Ischaemic Heart Disease
Ylä-Herttuala S. 2003 2003 -
Improved generation of recombinant baculovirus genomes in Escherichia coli
Airenne KJ, Peltomaa E, Hytönen VP, Laitinen OH, Ylä-Herttuala S. NUCLEIC ACIDS RESEARCH 31: e101. 2003 -
A stable bis-allyloxycarbonyl biotin aldehyde derivative for biotinylation via reductive alkylation: application to the synthesis of a biotinylated doxorubicin derivative
Allart B, Lehtolainen P, Yla-Herttuala S, Martin JF, Selwood DL. BIOCONJUGATE CHEMISTRY 14: 187-194. 2003 -
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue
Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, Kokina I, Achen MG, Stacker SA, Hedman M, Alitalo K, Ylä-Herttuala S. HUMAN GENE THERAPY 14: 1451-1462. 2003 -
Patterns of oxidized epitopes, but not NF-kappaB expression, change during atherogenesis in WHHL rabbits
Bräsen JH, Häkkinen T, Malle E, Beisiegel U, Ylä-Herttuala S. ATHEROSCLEROSIS 166 1: 13-21. 2003 -
Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death
Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OHJ, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. CANCER RESEARCH 63: 3195-3201. 2003 -
Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma
Gröhn OHJ, Valonen PK, Lehtimäki KK, Väisänen TH, Kettunen MI, Ylä-Herttuala S, Kauppinen RA, Garwood M. CANCER RESEARCH 63: 7571-7574. 2003 -
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]
Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S. CIRCULATION 107: 2677-2683. 2003 -
Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo
Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, Rutanen J, Kosma V-M, Mahonen A, Kröger H, Ylä-Herttuala S. FASEB JOURNAL 17: 1147-1149. 2003 -
DNA methylation, smooth muscle cells. and atherogenesis
Hiltunen MO, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 23: 1750-1753. 2003 -
Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor
Iivanainen E, Nelimarkka L, Elenius V, Heikkinen S-M, Junttila TT, Sihombing L, Sundvall M, Määttä JA, Laine VJO, Ylä-Herttuala S, Higashiyama S, Alitalo K, Elenius K. FASEB JOURNAL 17: 1609-1621. 2003 -
Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice
Jalkanen J, Leppänen P, Pajusola K, Närvänen O, Mähönen A, Vähäkangas E, Greaves DR, Büeler H, Ylä-Herttuala S. MOLECULAR THERAPY 8 6: 903-910. 2003 -
Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice
Jalkanen J, Leppänen Pia, Närvänen O, Graeves DR, Ylä-Herttuala S. ATHEROSCLEROSIS 169: 95-103. 2003 -
Evolving revascularization approaches for myocardial ischemia
Kleinman NS, Patel NC, Allen KB, Simons M, Ylä-Herttuala S, Griffin E, Dzau VJ. AMERICAN JOURNAL OF CARDIOLOGY. SUPPLEMENT 92 9: 9N-17N. 2003 -
Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo
Koponen JK, Kankkonen H, Kannasto J, Wirth T, Hillen W, Bujard H, Ylä-Herttuala S. GENE THERAPY 10 6: 459-466. 2003 -
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in Finnish subjects
Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M, Laakso M. DIABETES CARE 26: 179-182. 2003 -
Baculovirus capsid display: a novel tool for transduction imaging
Kukkonen SP, Airenne KJ, Marjomäki V, Laitinen OH, Lehtolainen P, Kankaanpää P, Mähönen AJ, Räty JK, Nordlund HR, Oker-Blom C, Kulomaa MS, Ylä-Herttuala S. MOLECULAR THERAPY 8 5: 853-862. 2003 -
Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures
Lampela P, Huotari M, Harjula A, Oinonen L, Ustav M, Ylä-Herttuala S, Männistö PT, Raasmaja A. PLASMID 50: 230-235. 2003 -
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes
Laurema A, Heikkilä A, Keski-Nisula L, Heikura T, Lehtolainen P, Manninen H, Tuomisto TT, Heinonen S, Ylä-Herttuala S. GENE THERAPY 10: 580-584. 2003 -
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*
Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. JOURNAL OF BIOLOGICAL CHEMISTRY 278 46: 45915-45923. 2003 -
Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein
Lehtolainen P, Wirth T, Taskinen AK, Lehenkari P, Leppänen O, Lappalainen M, Pulkkanen K, Marttila A, Marjomäki V, Airenne KJ, Horton M, Kulomaa MS, Ylä-Herttuala S. GENE THERAPY 10 25: 2090-2097. 2003 -
Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media
Liuba P, Persson J, Luoma J, Ylä-Herttuala S, Pesonen E. EUROPEAN HEART JOURNAL 24 6: 515-521. 2003 -
Co-infection with Chalamydia pneumoniae and Helicobacter pylori results in vascular endothelial dysfunction and enhanced VCAM-1 expression in apoE-knockout mice
Liuba P, Pesonen E, Paakkari I, Batra S, Andersen L, Forslid A, Ylä-Herttuala S, Persson K, Wadström T, Wang X, Laurini R. JOURNAL OF VASCULAR RESEARCH 40: 115-122. 2003 -
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects
Niskanen L, Lindi V, Erkkilä A, Sivenius K, Luoma J, Ylä-Herttuala S, Laakso M, Uusitupa MIJ, Laakso M. METABOLISM: CLINICAL AND EXPERIMENTAL 52 2: 213-217. 2003 -
Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis
Nykänen AI, Krebs R, Saaristo A, Turunen P, Alitalo K, Ylä-Herttuala S, Koskinen PK, Lemström KB. CIRCULATION 107: 1308-1314. 2003 -
Effect of adventitial VEGF165 gene transfer on vascular thickening after coronary artery balloon injury
Pels K, Deiner C, Coupland SE, Noutsias M, Sutter AP, Schultheiss H-P, Yla-Herttuala S, Schwimmbeck PL. CARDIOVASCULAR RESEARCH 60: 664-672. 2003 -
Fibroblast growth factor-4 induces vascular permeability, angiogenesis, and arteriogenesis in a rabbit hind limb ischemia model
Rissanen TT, Markkanen JE, Arve K, Rutanen J, Kettunen MI, Vajanto I, Jauhiainen S, Cashion L, Gruchala M, Närvänen O, Taipale P, Kauppinen RA, Rubanyi GM, Ylä-Herttuala S. FASEB JOURNAL 17: 100-102. 2003 -
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
Rissanen TT, Markkanen JE, Gruchala M, Heikura T, Puranen A, Kettunen MI, Kholová I, Kauppinen RA, Achen MG, Stacker SA, Alitalo K, Ylä-Herttuala S. CIRCULATION RESEARCH 92: 1098-1106. 2003 -
Preface
Rubanyi GM, Ylä-Herttuala S. Rubanyi GM, Ylä-Herttuala S, Human Gene Therapy: Current Opportunities and Future Trends.Springer. V-VII. 2003 -
Vascular endothelial growth factor-D expression in human atherosclerotic lesions
Rutanen J, Leppänen P, Tuomisto TT, Rissanen TT, Hiltunen MO, Vajanto I, Niemi M, Häkkinen T, Karkola K, Stacker SA, Achen MG, Alitalo K, Ylä-Herttuala S. CARDIOVASCULAR RESEARCH 59: 971-979. 2003 -
Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues
Tarkka T, Sipola A, Jämsä T, Soini Y, Ylä-Herttuala S, Tuukkanen J, Hautala T. JOURNAL OF GENE MEDICINE 5: 560-566. 2003 -
The Foundation of a Medical Revolution
Ylä-Herttuala S. 2003 2003 -
Gene expression in macrophage-rich inflammatory cell infiltrates in human atherosclerotic lesions as studied by laser microdissection and DNA array
Tuomisto TT, Korkeela A, Rutanen J, Viita H, Bräsen JH, Riekkinen M, Rissanen TT, Karkola K, Kiraly Z, Kölble K, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 23: 2235-2240. 2003 -
Genes involved in atherosclerosis and plaque formation
Tuomisto TT, Ylä-Herttuala S. Teoksessa: Van Eyk JE, Dunn MJ (toim.), Proteomic and Genomic Analysis of Cardiovascular Disease.Wiley. ss. 141-151. 2003 -
Cardiovascular gene therapy
Turunen MP, Hiltunen MO, Ylä-Herttuala S. Teoksessa: Rolland A, Sullivan SM (toim.) Pharmaceutical Gene Delivery Systems. Ei jufo-kustantaja/not jufo publisher. s. 345-362. 2003 -
Gene transfer as a tool to induce therapeutic vascular growth
Ylä-Herttuala S, Alitalo K. NATURE MEDICINE 9 6: 694-701. 2003 -
Angiogenesis clinical trials
Ylä-Herttuala S. Rubanyi GM, Ylä-Herttuala S, Human Gene Therapy: Current Opportunities and Future Trends.Springer. 19-23. 2003 -
Hero or villain?
Ylä-Herttuala S. GENE THERAPY 10: 193. 2003 -
Novel targeting of biotinylated compounds to local tissues with avidin-lipoprotein receptor fusion protein
Ylä-Herttuala S. DISCOVERY MEDICINE 3 19: 47-48. 2003 -
Percutaneous transcoronary venous access for cellular cardiomyoplasty
Ylä-Herttuala S. LANCET 362: 1252. 2003 -
Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits
Bräsen JH, Koenig K, Bach H, Kontush A, Heinle H, Witting PK, Ylä-Herttuala S, Stocker R, Beisiegel U. ATHEROSCLEROSIS 163: 249-259. 2002 -
Early gene therapy - induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame
Hakumäki JM, Gröhn OHJ, Tyynelä K, Valonen P, Ylä-Herttuala S, Kauppinen RA. CANCER GENE THERAPY 9: 338-345. 2002 -
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K. JOURNAL OF THE NATIONAL CANCER INSTITUTE 94 11: 819-825. 2002 -
Gene transfer to human placenta ex vivo: A novel application of dual perfusion of human placental cotyledon
Heikkilä A, Myllynen P, Keski-Nisula L, Heinonen S, Vähäkangas K, Ylä-Herttuala S. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 186: 1046-1051. 2002 -
Changes in gene expression in atherosclerotic plaques analyzed using DNA array
Hiltunen MO, Tuomisto TT, Niemi M, Bräsen JH, Rissanen TT, Törönen P, Vajanto I, Ylä-Herttuala S. ATHEROSCLEROSIS 165: 23-32. 2002 -
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. VASCULAR MEDICINE (LONDON) 7: 5-11. 2002 -
Escherichia coli DNA contamination in AmpliTag Gold polymerase interferes with TagMan analysis of IacZ
Koponen JK, Turunen A-M, Ylä-Herttuala S. MOLECULAR THERAPY 5 3: 220-222. 2002 -
Improvement in adenoviral gene transfer efficiency after preincubation at +37oC in vitro and in vivo
Kossila M, Jauhiainen S, Laukkanen MO, Lehtolainen P, Jääskeläinen M, Turunen P, Loimas S, Wahlfors J, Ylä-Herttuala S. MOLECULAR THERAPY 5 1: 87-93. 2002 -
The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures
Lampela P, Räisänen J, Männistö PT, Ylä-Herttuala S, Raasmaja A. JOURNAL OF GENE MEDICINE 4 2: 205-214. 2002 -
Cloning and characterization of soluble decoy receptors
Laukkanen J, Ylä-Herttuala S. Sen CK, Packer L, Redox Cell Biology and Genetics. Part B.Elsevier. Methods in Enzymology. 337-345. 2002 -
Genes involved in atherosclerosis
Laukkanen J, Ylä-Herttuala S. NEPHRON. EXPERIMENTAL NEPHROLOGY 10: 150-163. 2002 -
Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta
Laukkanen MO, Kivelä A, Rissanen T, Rutanen J, Karkkainen MK, Leppanen O, Bräsen JH, Yla-Herttuala S. CIRCULATION 106: 1999-2003. 2002 -
Cloning and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules
Lehtolainen P, Taskinen A, Laukkanen J, Airenne KJ, Heino S, Lappalainen M, Ojala K, Marjomäki V, Martin JF, Kulomaa MS, Ylä-Herttuala S. JOURNAL OF BIOLOGICAL CHEMISTRY 277 10: 8545-8550. 2002 -
Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo
Lehtolainen P, Tyynelä K, Kannasto J, Airenne KJ, Ylä-Herttuala S. GENE THERAPY 9: 1693-1699. 2002 -
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis
Lemström KB, Krebs R, Nykänen AI, Tikkanen JM, Sihvola RK, Aaltola EM, Häyry PJ, Wood J, Alitalo K, Ylä-Herttuala S, Koskinen PK. CIRCULATION 105: 2524-2530. 2002 -
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S. MOLECULAR THERAPY 6 1: 127-133. 2002 -
Apolipoprotein E and colon cancer. Expression in normal and malignant human intestine and effect on cultured human colonic adenocarcinoma cells
Niemi M, Häkkinen T, Karttunen TJ, Eskelinen S, Kervinen K, Savolainen MJ, Lehtola J, Mäkelä J, Ylä-Herttuala S, Kesäniemi YA. EUROPEAN JOURNAL OF INTERNAL MEDICINE 13: 37-43. 2002 -
Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells
Pajusola K, Gruchala M, Joch H, Lüscher TF, Ylä-Herttuala S, Büeler H. JOURNAL OF VIROLOGY 76 22: 11530-11540. 2002 -
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
Petrova TV, Mäkinen T, Mäkelä TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN, Kerjaschki D, Ylä-Herttuala S, Alitalo K. EMBO JOURNAL 21 17: 4593-4599. 2002 -
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice
Pulkkanen KJ, Laukkanen JM, Fuxe J, Kettunen MI, Rehn M, Kannasto JM, Parkkinen JJ, Kauppinen RA, Pettersson RF, Yla-Herttuala S. CANCER GENE THERAPY 9: 908-916. 2002 -
Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration
Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M, Leppänen P, Turunen MP, Markkanen JE, Arve K, Alhava E, Kauppinen RA, Ylä-Herttuala S. AMERICAN JOURNAL OF PATHOLOGY 160 4: 1393-1403. 2002 -
Gene therapy for restenosis. Current status
Rutanen J, Markkanen J, Ylä-Herttuala S. DRUGS 62: 1575-1585. 2002 -
Post-intervention vessel remodeling
Rutanen J, Puhakka H, Ylä-Herttuala S. GENE THERAPY 9: 1487-1491. 2002 -
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, Turunen P, Jeltsch M, Karkkainen MJ, Kerjaschki D, Bueler H, Ylä-Herttuala S, Alitalo K. FASEB JOURNAL 16: 1041-1049. 2002 -
Lymphangiogenic gene therapy with minimal blood vascular side effects
Saaristo A, Veikkola T, Tammela T, Enholm B, Karkkainen MJ, Pajusola K, Bueler H, Ylä-Herttuala S, Alitalo K. JOURNAL OF EXPERIMENTAL MEDICINE 196 6: 719-730. 2002 -
Local cardiovascular gene therapy
Turunen MP, Hiltunen MO, Ylä-Herttuala S. Mahato RI, Wan Kim S, Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics.Taylor & Francis. 487-498. 2002 -
Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer
Turunen MP, Puhakka HL, Koponen JK, Hiltunen MO, Rutanen J, Leppänen O, Turunen A-M, Närvänen A, Newby AC, Baker AH, Ylä-Herttuala S. MOLECULAR THERAPY 6: 306-312. 2002 -
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model
Tyynelä K, Sandmair A-M, Turunen M, Vanninen R, Vainio P, Kauppinen R, Johansson R, Vapalahti M, Ylä-Herttuala S. CANCER GENE THERAPY 9 11: 917-924. 2002 -
Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ
Vajanto I, Rissanen TT, Rutanen J, Hiltunen MO, Tuomisto TT, Arve K, Närvänen O, Manninen H, Räsänen H, Hippeläinen M, Alhava E, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 4: 371-380. 2002 -
Therapeutic angiogenesis: How far from clinical practice?
Ylä-Herttuala S. EVERYDAY PROBLEMS IN CLINICAL CARDIOLOGY 12 3: 4-7. 2002 -
Angiogenesis, vascular endothelial growth factor and platelet-derived growth factor-BB expression, iron deposition, and oxidation-specific epitopes in stented human coronary arteries
Bräsen JH, Kivelä A, Röser K, Rissanen TT, Niemi M, Luft FC, Donath K, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 21: 1720-1726. 2001 -
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin
Enholm B, Karpanen T, Jeltsch M, Kubo H, Stenback F, Prevo R, Jackson DG, Yla-Herttuala S, Alitalo K. CIRCULATION RESEARCH 88: 623-629. 2001 -
Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions
Greaves DR, Häkkinen T, Lucas AD, Liddiard K, Jones E, Quinn CM, Senaratne J, Green FR, Tyson K, Boyle J, Shanahan C, Weissberg PL, Gordon S, Ylä-Hertualla S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 21: 923-929. 2001 -
Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes
Heikkilä A, Hiltunen MO, Turunen MP, Keski-Nisula L, Turunen A-M, Räsänen H, Rissanen TT, Kosma V-M, Manninen H, Heinonen S, Ylä-Herttuala S. GENE THERAPY 8: 784-788. 2001 -
Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions
Heydeck D, Upston JM, Viita H, Ylä-Herttuala S, Stocker R. JOURNAL OF LIPID RESEARCH 42: 1082-1088. 2001 -
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor
Hiltunen TP, Gough PJ, Greaves DR, Gordon S, Ylä-Herttuala S. ATHEROSCLEROSIS 154: 415-419. 2001 -
A model for gene therapy of human hereditary lymphedema
Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Ylä-Herttuala S, Finegold DN, Ferrell RE, Alitalo K. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98 22: 12677-12682. 2001 -
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
Karpanen T, Egeblad M, Karkkainen MJ, Kubo H, Ylä-Herttuala S, Jäättelä M, Alitalo K. CANCER RESEARCH 61: 1786-1790. 2001 -
EC-SOD gene therapy reduces paracetamol-induced liver damage in mice
Laukkanen MO, Leppanen P, Turunen P, Tuomisto T, Naarala J, Yla-Herttuala S. JOURNAL OF GENE MEDICINE 3: 321-325. 2001 -
Gene transfer of extracellular superoxide dismutase to atherosclerotic mice
Laukkanen MO, Leppänen P, Turunen P, Porkkala-Sarataho E, Salonen JT, Ylä-Herttuala S. ANTIOXIDANTS AND REDOX SIGNALING 3 3: 397-402. 2001 -
Optimized in situ PCR method for the detection of gene transfer vector in histological sections
Leppänen PM, Koponen J, Turunen MP, Pakkanen T, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 3: 173-178. 2001 -
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S-I, Ylä-Herttuala S, Alitalo K. NATURE MEDICINE 7 2: 199-205. 2001 -
Evaluation and characterization of EIA measuring autoantibodies against oxidized LDL
Närvänen O, Erkkilä A, Ylä-Herttuala S. FREE RADICAL BIOLOGY & MEDICINE 31 6: 769-777. 2001 -
Technical and clinical aspects about autoantibody assays for oxidized low density lipoprotein
Närvänen O, Luoma J, Ylä-Herttuala S. Shoenfeld Y, Harats D, Wick G, Atherosclerosis and Autoimmunity. Section V. Anti-Endothelial Cell Antibodies and Atherosclerosis.Elsevier. 173-179. 2001 -
HSV-tk gene therapy for human renal cell carcinoma in nude mice
Pulkkanen KJ, Parkkinen JJ, Laukkanen JM, Kettunen MI, Tyynela K, Kauppinen RA, Ala-Opas MY, Yla-Herttuala S. CANCER GENE THERAPY 8: 529-536. 2001 -
Gene therapy for therapeutic angiogenesis in critically inschaemic lower limb - on the way to the clinic
Rissanen TT, Vajanto I, Ylä-Herttuala S. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 31: 651-666. 2001 -
Clinical applications of vascular gene therapy
Rutanen J, Rissanen TT, Kivelä A, Vajanto I, Ylä-Herttuala S. CURRENT CARDIOLOGY REPORTS 3: 29-36. 2001 -
Extracellular superoxide dismutase deficiency and atherosclerosis in mice
Sentman M-L, Brännström T, Westerlund S, Laukkanen MO, Ylä-Herttuala S, Basu S, Marklund SL. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 21: 1477-1482. 2001 -
Geeniterapia
Ylä-Herttuala S. SUOMEN PROVIISORILEHTI 1: 10. 2001 -
Gene therapy for coronary heart disease
Ylä-Herttuala S. JOURNAL OF INTERNAL MEDICINE 250: 367-368. 2001 -
Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery
Airenne KJ, Hiltunen MO, Turunen MP, Turunen A-M, Laitinen OH, Kulomaa MS, Ylä-Herttuala S. GENE THERAPY 7: 1499-1504. 2000 -
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells
Brigelius-Flohé R, Maurer S, Lötzer K, Böl G-F, Kallionpää H, Lehtolainen P, Viita H, Ylä-Herttuala S. ATHEROSCLEROSIS 152: 307-316. 2000 -
Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease
Erkkilä AT, Närvänen O, Lehto S, Uusitupa MIJ, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 204-209. 2000 -
Geenihoidolla aikaansaadun apoptoosin havaitseminen käyttäen 1H-magneettispektroskopiaa in vivo
Hakumäki JM, Poptani H, Sandmair A-M, Ylä-Herttuala S, Kauppinen RA. DUODECIM 116: 619-620. 2000 -
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease
Hedman M, Ylä-Herttuala S. DRUGS OF TODAY 36: 609-617. 2000 -
Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta
Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. CIRCULATION 102: 2262-2268. 2000 -
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer
Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. VASCULAR MEDICINE (LONDON) 5: 41-48. 2000 -
Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods
Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. FASEB JOURNAL 14: 2230-2236. 2000 -
Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions
Häkkinen T, Karkola K, Ylä-Herttuala S. VIRCHOWS ARCHIV 437: 396-405. 2000 -
Gene therapy for atherosclerosis and restenosis
Kivelä A, Turunen A-M, Ylä-Herttuala S. CURRENT OPINION IN CARDIOVASCULAR, PULMONARY & RENAL INVESTIGATIONAL DRUGS 2 3: 244-249. 2000 -
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes
Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen MO, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M. DIABETES (NY) 49: 1740-1743. 2000 -
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. HUMAN GENE THERAPY 11: 263-270. 2000 -
Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradiation and foam-cell formation in macrophages
Laukkanen J, Lehtolainen P, Gough PJ, Graeves DR, Gordon S, Ylä-Herttuala S. CIRCULATION 101: 1091-1096. 2000 -
Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation
Laukkanen MO, Lehtolainen P, Turunen P, Aittomäki S, Oikari P, Marklund SL, Ylä-Herttuala S. GENE 254: 173-179. 2000 -
Retrovirus-mediated, stable scavenger-receptor gene transfer leads to functional endocytotic receptor expression, foam cell formation, and increased susceptibility to apoptosis in rabbit aortic smooth muscle cells
Lehtolainen P, Takeya M, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 52-60. 2000 -
Adenovirus-mediated gene transfer into an experimental pancreatic tumour
Mäkinen K, Loimas S, Kosma VM, Wahlfors J, Ylä-Herttuala S, Alhava E, Jänne J. SCANDINAVIAN JOURNAL OF SURGERY 89: 99-103. 2000 -
Gene therapy for dyslipidaemias
Pakkanen T, Ylä-Herttuala S. EUROPEAN HEART JOURNAL. SUPPLEMENTS 2: D62-D64. 2000 -
Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes
Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S. JOURNAL OF GENE MEDICINE 2: 52-60. 2000 -
False-positive apoptosis signal in mouse kidney and liver detected with TUNEL assay
Pulkkanen KJ, Laukkanen MO, Naarala J, Yla-Herttuala S. APOPTOSIS 5 4: 329-333. 2000 -
Characterization of a new animal model for human renal cell carcinoma
Pulkkanen KJ, Parkkinen JJ, Kettunen MI, Kauppinen RA, Lappalainen M, Ala-Opas MY, Ylä-Herttuala S. IN VIVO (ATHENS) 14: 393-400. 2000 -
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
Sandmair A-M, Loimas S, Puranen P, Immonen A, Kossila M, Puranen M, Hurskainen H, Tyynelä K, Turunen M, Vanninen R, Lehtolainen P, Paljärvi L, Johansson R, Vapalahti M, Ylä-Herttuala S. HUMAN GENE THERAPY 11: 2197-2205. 2000 -
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions
Sandmair A-M, Turunen M, Tyynelä K, Loimas S, Vainio P, Vanninen R, Vapalahti M, Bjerkvig R, Jänne J, Ylä-Herttuala S. CANCER GENE THERAPY 7 3: 413-421. 2000 -
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors
Sandmair A-M, Vapalahti M, Ylä-Herttuala S. Habib NA, Cancer Gene Therapy. Past Achievements and Future Challenges.Kluwer. Advances in Experimental Medicine and Biology. 163-170. 2000 -
Adenoviruses as gene delivery vectors
Sandmair A-M, Vapalahti M, Ylä-Herttuala S. Habib NA, Cancer Gene Therapy. Past Achievements and Future Challenges.Kluwer. Advances in Experimental Medicine and Biology. 423-429. 2000 -
Effects of lipoxygenases on gene expression in mammalian cells
Viita H, Ylä-Herttuala S. Teoksessa: Sen CK, Sies H, Baeuerle PA (toim.), Antioxidant and Redox Regulation of Genes.Academic Press. ss. 339-358. 2000 -
Eläinkokeet ja niiden vaihtoehdot
Viluksela M, Ylä-Herttuala S. NATURA 37 2: 5-9. 2000 -
lacZ-neoR transfected glioma cells in syngeneic rats: growth pattern and characterization of the host immune response against cells transplanted inside and outside the CNS
Visted T, Thorsen J, Thorsen F, Read T-A, Ulvestad E, Engebraaten O, Sørensen D, Ylä-Herttuala S, Tyynela K, Rucklidge G, Edvardsen K, Bjerkvig R, Lund-Johansen M. INTERNATIONAL JOURNAL OF CANCER 85: 228-235. 2000 -
Cardiovascular gene therapy
Ylä-Herttuala S, Martin JF. LANCET 355: 213-222. 2000 -
Oxidized low-density lipoproteins and atherosclerosis
Ylä-Herttuala S, Pakkanen T, Leppänen P, Häkkinen T. JOURNAL OF CLINICAL AND BASIC CARDIOLOGY 3: 87-88. 2000 -
Vascular protection. A novel nonangiogenic cardiovascular role for vascular endothelial growth factor
Zachary I, Mathur A, Yla-Herttuala S, Martin J. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 20: 1512-1520. 2000 -
Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum
Agrawal RS, Karhu K, Laukkanen J, Kirkinen P, Ylä-Herttuala S, Agrawal YP. GENE THERAPY 6: 146-148. 1999 -
Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
Gough PJ, Greaves DR, Suzuki H, Hakkinen T, Hiltunen MO, Turunen M, Ylä-Herttuala S, Kodama T, Gordon S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 461-471. 1999 -
1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis
Hakumäki JM, Poptani H, Sandmair A-M, Ylä-Herttuala S, Kauppinen RA. NATURE MEDICINE 5 11: 1323-1327. 1999 -
Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both
Heitzer T, Ylä-Herttuala S, Wild E, Luoma J, Drexler H. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 33 2: 499-505. 1999 -
Functional genomics and DNA array techniques in atherosclerosis research
Hiltunen MO, Niemi M, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 10: 515-519. 1999 -
Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions
Häkkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2909-2917. 1999 -
Local hypomethylation in atherosclerosis found in rabbit ec-sod gene
Laukkanen MO, Mannermaa S, Hiltunen MO, Aittomäki S, Airenne K, Jänne J, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 2171-2178. 1999 -
Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease
Lehtimäki T, Lehtinen S, Solakivi T, Nikkilä M, Jaakkola O, Jokela H, Ylä-Herttuala S, Luoma JS, Koivula T, Nikkari T. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 19: 23-27. 1999 -
Sydän- ja verisuonisairauksien geenihoito
Luoma J, Ylä-Herttuala S. SUOMEN LÄÄKÄRILEHTI 54: 1809-1814. 1999 -
Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions
Luoma JS, Ylä-Herttuala S. VIRCHOWS ARCHIV 434: 561-568. 1999 -
Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus
Mäkimattila S, Luoma JS, Ylä-Herttuala S, Bergholm R, Utriainen T, Virkamäki A, Mäntysaari M, Summanen P, Yki-Järvinen H. ATHEROSCLEROSIS 147: 115-122. 1999 -
Gene therapy for atherosclerosis and atherosclerosis-related diseases
Pakkanen T, Ylä-Herttuala S. CURRENT ATHEROSCLEROSIS REPORTS 1 2: 123-130. 1999 -
Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment
Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S. PHARMACOLOGICAL RESEARCH 40 5: 451-457. 1999 -
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res
Pakkanen TM, Laitinen M, Hippeläinen M, Kallionpää H, Lehtolainen P, Leppänen P, Luoma JS, Tarvainen R, Alhava E, Ylä-Herttuala S. GENE THERAPY 6: 34-41. 1999 -
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies
Ruponen M, Ylä-Herttuala S, Urtti A. BIOCHIMICA ET BIOPHYSICA ACTA 1415: 331-341. 1999 -
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment
Sandmair A-M, Loimas S, Poptani H, Vainio P, Vanninen R, Turunen M, Tyynelä K, Vapalahti M, Ylä-Herttuala S. ACTA NEUROCHIRURGICA (WIEN) 141: 867-873. 1999 -
Geeniterapia ja sen mahdollisuudet verisuonitautien hoidossa
Turunen M, Hiltunen M, Ylä-Herttuala S. KEMIA-KEMI 26: 186-188. 1999 -
Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes
Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC Jr, Urtti A, Ylä-Herttuala S. GENE THERAPY 6: 6-11. 1999 -
Gene therapy for angiogenesis, restenosis and related diseases
Turunen MP, Hiltunen MO, Ylä-Herttuala S. EXPERIMENTAL GERONTOLOGY 34: 567-574. 1999 -
Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein
Viita H, Närvänen O, Ylä-Herttuala S. LIFE SCIENCES 65 8: 783-793. 1999 -
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells
Viita H, Sen CK, Roy S, Siljamäki T, Nikkari T, Ylä-Herttuala S. ANTIOXIDANTS AND REDOX SIGNALING 1 1: 83-96. 1999 -
Metabolism of modified LDL and foam cell formation in murine macrophage-like raw 264 cells
Ylitalo R, Jaakkola O, Lehtolainen P, Ylä-Herttuala S. LIFE SCIENCES 64 21: 1955-1965. 1999 -
Oxidized LDL and atherogenesis
Ylä-Herttuala S. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 874: 134-137. 1999 -
Pathogenesis and treatment of atherosclerosis-related diseases: challenges for vascular biology in the next millennium
Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 10: 483-484. 1999 -
Vascular gene therapy - early clinical results with angiogenic growth factors
Ylä-Herttuala S. Dormandy JA, Dole WP, Rubanyi GM, Therapeutic Angiogenesis.Springer . 175-181. 1999 -
Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation
Ahotupa M, Marniemi J, Lehtimäki T, Talvinen K, Raitakari OT, Vasankari T, Viikari J, Luoma J, Ylä-Herttuala S. CLINICAL BIOCHEMISTRY 31 4: 257-261. 1998 -
The atherosclerotic lesion: a dynamic landscape
Berliner J, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 9: 385-386. 1998 -
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: Identification of apoptotic response
Hakumäki JM, Poptani H, Puumalainen A-M, Loimas S, Paljärvi LA, Ylä-Herttuala S, Kauppinen RA. CANCER RESEARCH 58: 3791-3799. 1998 -
Postmenopausal hormone replacement therapy and autoantibodies against oxidized LDL
Heikkinen A-M, Niskanen L, Ylä-Herttuala S, Luoma J, Tuppurainen MT, Komulainen M, Saarikoski S. MATURITAS 29: 155-161. 1998 -
Geeniterapia verisuonitautien hoidossa
Hiltunen MO, Turunen MP, Ylä-Herttuala S. DOSIS : FARMASEUTTINEN AIKAKAUSKIRJA 14 4: 202-206. 1998 -
Kani eläinmallina ateroskleroosin geeniterapiatutkimuksissa
Hiltunen MO, Ylä-Herttuala S. KOEKUKKO. KUOPION YLIOPISTO. VALTAKUNNALLINEN KOE-ELÄINKESKUS 18 2: 28-32. 1998 -
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions. Marked induction of scavenger receptor and VLDL receptor expression during lesion development
Hiltunen TP, Luoma JS, Nikkari T, Ylä-Herttuala S. CIRCULATION 97: 1079-1086. 1998 -
Expression of lipoprotein receptors in atherosclerotic lesions
Hiltunen TP, Ylä-Herttuala S. ATHEROSCLEROSIS. SUPPLEMENT 137: S81-S88. 1998 -
Artifact occurring during combined in situ hybridization and immunocytochemistry analysis because of positive chemography
Häkkinen T, Ylä-Herttuala S. BIOTECHNIQUES 24: 730-732. 1998 -
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S. HUMAN GENE THERAPY 9: 1481-1486. 1998 -
Adventitial gene transfer to arterial wall
Laitinen M, Ylä-Herttuala S. PHARMACOLOGICAL RESEARCH 37 4: 251-254. 1998 -
Adventitial gene transfer to rabbit carotid arteries
Laitinen M, Ylä-Herttuala S. Teoksessa: Jacotot B, Mathé D, Fruchart J-C (toim.), Atherosclerosis XI. XIth International Symposium on Atherosclerosis.Elsevier. ss. 689-691. 1998 -
Vascular gene transfer for the treatment of restenosis and atherosclerosis
Laitinen M, Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 9: 465-469. 1998 -
The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus
Leinonen JS, Rantalaiho V, Laippala P, Wirta O, Pasternack A, Alho H, Jaakkola O, Ylä-Herttuala S, Koivula T, Lehtimäki T. FREE RADICAL RESEARCH 29: 137-141. 1998 -
Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice
Leppänen P, Luoma JS, Hofker MH, Havekes LM, Ylä-Herttuala S. ATHEROSCLEROSIS 136: 147-152. 1998 -
Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins
Luoma JS, Strålin P, Marklund SL, Hiltunen TP, Särkioja T, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 18: 157-167. 1998 -
Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings
Manninen HI, Vanninen RL, Laitinen M, Räsänen H, Vainio P, Luoma JS, Pakkanen T, Tulla H, Ylä-Herttuala S. INVESTIGATIVE RADIOLOGY 33 8: 464-471. 1998 -
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging
Poptani H, Puumalainen A-M, Gröhn OH, Loimas S, Kainulainen R, Ylä-Herttuala S, Kauppinen RA. CANCER GENE THERAPY 5 2: 101-109. 1998 -
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
Puumalainen A-M, Vapalahti M, Agrawal RS, Kossila M, Laukkanen J, Lehtolainen P, Viita H, Paljärvi L, Vanninen R, Ylä-Herttuala S. HUMAN GENE THERAPY 9: 1769-1774. 1998 -
Gene therapy for malignant glioma patients
Puumalainen A-M, Vapalahti M, Ylä-Herttuala S. Walden P...[et al.], Gene Therapy of Cancer. Proceedings of the Third European Conference on Gene Therapy of Cancer.Plenum Press. 505-509. 1998 -
Geenihoidon mahdollisuudet ja vaarat
Puumalainen A-M, Vapalahti M, Ylä-Herttuala. SIELUNHOIDON AIKAKAUSKIRJA 10: 37-42. 1998 -
Effects of liposome-encapsulated bisphosphonates on acetylated LDL metabolism, lipid accumulation and viability of phagocyting cells
Ylitalo R, Mönkkönen J, Ylä-Herttuala S. LIFE SCIENCES 62 5: 413-422. 1998 -
Gene therapy and brain tumors
Ylä-Herttuala S. Mikkelsen T, Bjerkvig R, Laerum OD, Rosenblum ML, Brain Tumor Invasion: Biological, Clinical and Therapeutic Considerations.Wiley-Liss. 435-445. 1998 -
Is oxidized low-density lipoprotein present in vivo?
Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 9: 337-344. 1998 -
Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses
Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agraval R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Ylä-Herttuala S. HUMAN GENE THERAPY 8: 1645-1650. 1997 -
Genteknologins möjligheter vid hjärt- och kärlsjukdomar
Laitinen M, Ylä-Herttuala S. FINSK TIDSKRIFT 9-10: 527-536. 1997 -
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S. HUMAN GENE THERAPY 8: 1737-1744. 1997 -
Geeniterapian mahdollisuudet aivokasvainten hoidossa
Puumalainen A-M, Vapalahti M, Ylä-Herttuala S. SUOMEN LÄÄKÄRILEHTI 52 22-23: 2503-2506. 1997 -
In vivo low density lipoprotein oxidation relates to coronary reactivity in young men
Raitakari OT, Pitkänen O-P, Lehtimäki T, Lahdenperä S, Iida H, Ylä-Herttuala S, Luoma J, Mattila K, Nikkari T, Taskinen M-R, Viikari JSA, Knuuti J. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 30 1: 97-102. 1997 -
Release of replication-deficient retroviruses from a packaging cell line: interaction with glioma tumor spheroids in vitro
Thorsen F, Visted T, Lehtolainen P, Ylä-Herttuala S, Bjerkvig R. INTERNATIONAL JOURNAL OF CANCER 71: 874-880. 1997 -
Geenihoidon lainsäädännölliset ja eettiset ongelmat
Vapalahti M, Puumalainen A-M, Ylä-Herttuala S. SUOMEN LÄÄKÄRILEHTI 52 22-23: 2546-2549. 1997 -
Geeniteknologia tulevaisuuden lääketieteessä
Ylä-Herttuala S. SUOMEN LÄÄKÄRILEHTI 52 17: 2109-2116. 1997 -
Vascular gene transfer
Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 8: 72-76. 1997 -
Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL
Heitzer T, Ylä-Herttuala S, Luoma J, Kurz S, Münzel T, Just H, Olschewski M, Drexler H. CIRCULATION 93: 1346-1353. 1996 -
Atherosclerosis in Watanabe heritable hyperlipidemic rabbit arteries
Luoma J, Ylä-Herttuala S. SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE 23 4: 195-197. 1996 -
Involvement of specific macrophage-lineage cells surrounding aterioles in barrier and scavenger function in brain cortex
Mato M, Ookawara S, Sakamoto A, Aikawa E, Ogawa T, Mitsuhashi U, Masuzawa T, Suzuki H, Honda M, Yazaki Y, Watanabe E, Luoma J, Yla-Herttuala S, Fraser I, Gordon S, Kodama T. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93: 3269-3274. 1996 -
Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus
Uusitupa MIJ, Niskanen L, Luoma J, Vilja P, Mercuri M, Rauramaa R, Ylä-Herttuala S. ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY 16: 1236-1242. 1996 -
Pathogenesis of atherosclerosis
Ylä-Herttuala S, Luoma J, Kallionpää H, Laukkanen M, Lehtolainen P, Viita H. MATURITAS. SUPPLEMENT 23: S47-S49. 1996 -
Ihmisen geeniterapia
Ylä-Herttuala S, Ollikainen A, Vapalahti M. DUODECIM 112 2: 77-79. 1996 -
Expression of lipoprotein receptors and related molecules in atherosclerotic lesions
Ylä-Herttuala S. CURRENT OPINION IN LIPIDOLOGY 7: 292-297. 1996 -
Gene therapy for cardiovascular diseases
Ylä-Herttuala S. Annals of Medicine 28: 89-93. 1996 -
LDL oxidation and atherogenesis
Ylä-Herttuala S. Kumpulainen JT, Salonen JT, Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention.The Royal Society of Chemistry. 7-10. 1996 -
Oksidoituneet lipoproteiinit ja valtimonkovettumatauti
Ylä-Herttuala S. KLIIN LAB 13 1: 4-5. 1996 -
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions
Hiltunen T, Luoma J, Nikkari T, Ylä-Herttuala S. CIRCULATION 92 11: 3297-3303. 1995 -
Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease
Niemelä O, Parkkila S, Ylä-Herttuala S, Villanueva J, Ruebner B, Halsted CH. HEPATOLOGY 22 4: 1208-1214. 1995 -
Experimental liver cirrhosis induced by alcohol and iron
Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, Brittenham GM. JOURNAL OF CLINICAL INVESTIGATION 96: 620-630. 1995 -
Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein
Ylä-Herttuala S, Luoma J, Viita H, Hiltunen T, Sisto T, Nikkari T. JOURNAL OF CLINICAL INVESTIGATION 95: 2692-2698. 1995