Seppo Ylä-Herttuala

Tarkenna hakuasi

Nykyiset vastuutehtävät

– Molekulaarisen lääketieteen professori
– Biokeskus Kuopion johtaja
– EU EATRIS-ERIC infrastruktuuriverkoston kansallinen johtaja
– Kansallisen virusvektorilaboratorion johtaja

Tutkimusryhmät

Molekulaarinen lääketiede 01.01.1995 -

Projektit

GeneCellNano-lippulaiva 01.07.2020 - 30.06.2028

- 1987 FT (Lääketiede), Tampereen yliopisto
- 1982 Lääketieteen lisensiaatti, Tampereen yliopisto
- 1978 Lääketieteen kandidaatti, Tampereen yliopisto
- 2020-2021 Vice Chairman of the ERC Synergy Grant Panel LS7
- 2018-2021 Chairman of Biocenter Finland, University of Helsinki
- 2018-current Board member of the Foundation for Research on Viral Diseases
- 2015-current Associate Editor of Cardiovascular Reserach (Offical Journal of the European Society of Cardiology)
- 2015-2019 Editor-in-Chief of Molecular Therapy (Official Journal of the American Society of Gene and Cell Therapy)
- 2015-2017 Chairman and Board Member, Instrumentarium Science Foundation
- 2014-2016 Chairman, American Society of Gene and Cell Therapy, Cardiovascular Committee
- 2014-2015 Member, American Society of Gene and Cell Therapy, Nominating Committee
- 2012-2013, 2015-2017 Chairman of the ERC consolidated grant panel LS7
- 2011-2017 Chairman and Board Member, Biocenter Oulu, University of Oulu
- 2011-2014 Deputy Member of Board, Institute for Molecular Medicine, University of Helsinki
- 2010-2015 Vice Chairman and Board Member, Instrumentarium Science Foundation
- 2010-2012 Chairman, Biocenter Finland, University of Helsinki
- 2010-2012 President of European Society of Gene and Cell Therapy
- 2008-current Director of Biocenter Kuopio, University of Eastern Finland
- 2005-2020 Academy Professor, Academy of Finland
- 2005-2006 Visiting Professor, Salk Institute, Laboratory of Genetics (Prof. Inder Verma), USA
- 1995- Professor of Molecular Medicine, A.I. Virtanen Institute
- 1992-1995 Senior Research Fellow, Academy of Finland
- 1991-1995 Senior Lecturer in Medical Biochemistry, University of Tampere
- 1991-1992 Junior Research Fellow, Academy of Finland
- 1988-1991 Post-doctoral Fellow, University of California, San Diego, USA (Dr. Daniel Steinberg and Dr. Joseph Witztum)
- 1985-1988 Research Assistant, Academy of Finland
- 1983-1985 Research Associate, University of Tampere

Julkaisut

719/719 kappaletta

Tarkenna hakuasi

Seppo Ylä-Herttuala

Tutkimusryhmät

Projektit

Akateemiset tutkinnot

Merkittävät vastuutehtävät

Caridac vein retroinjections provide an efficient approach for global left ventricular gene transfer with adenovirus and adeno-associated virus

Cell-Specific Targeting of the Endothelium in the CardioRenal Syndrome

Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice

Efficacy of Intravesical Nadofaragene Firadenovec for Patients With Bacillus Calmette-Guérin–Unresponsive Nonmuscle-Invasive Bladder Cancer: 5-Year Follow-Up From a Phase 3 Trial

Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials and Challenges

Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors

Navigating the prime editing strategy to treat cardiovascular genetic disorders in transforming heart health

Optimizing lentiviral vector formulation conditions for efficient ex vivo transduction of primary human T cells in chimeric antigen receptor T-cell manufacturing

SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery

Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium

COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors

Comparison of Automated and Traditional Western Blotting Methods

Critical limb-threatening ischemia and microvascular transformation: clinical implications

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component

Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Geeniterapia avaa uusia virtsarakkosyövän hoitomahdollisuuksia

Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors

Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times

New Twist in Cell Therapy for the Treatment of Severe Ischemia

Proangiogenic Growth Factor Therapy for the Treatment of Refractory Angina: A Meta-analysis

Role of non-coding RNAs in physiological and pathological angiogenesis

SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia

Antiangiogenic AAV2 gene therapy with a truncated form of soluble VEGFR-2 reduces the growth of choroidal neovascularization in mice after intravitreal injection

Decreased Gray–White Matter Contrast of [11C]-PiB Uptake in Cognitively Unimpaired Subjects with Severe Obstructive Sleep Apnea

Endocardial Gene Delivery Using NOGA Catheter System

Intramyocardial adenoviral vascular endothelial growth factor‐D∆N∆C gene therapy does not induce ventricular arrhythmias

Lentiviral interferon: A novel method for gene therapy in bladder cancer

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Preclinical Evaluation of Coronary Artery Stents

RNA interference-based therapies for the control of atherosclerosis risk factors

Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence

Strategies to improve safety profile of AAV vectors

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?

Translational opportunities of single-cell biology in atherosclerosis

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta

Adenoviral gene transfer of Gremlin modulates VEGF-A induced angiogenesis in porcine myocardium

ASGCT Annual Meeting 2019

Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function

Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

DNA methylation processes in atheosclerotic plaque

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Gene Therapy of Critical Limb Ischemia Enters Clinical Use

Gene and Cell Therapy: Success Stories and Future Challenges

Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis

Isolation of fresh endothelial cells from porcine heart for cardiovascular studies: a new fast protocol suitable for genomic, transcriptomic and cell biology studies

Molecular Imaging to Monitor Left Ventricular Remodeling in Heart Failure