Katja Kanninen

Characterisation of a patient-derived iPSC-based model for studying the blood-brain barrier in Alzheimer’s disease

Wagner, Sylvia; Danz, Karin; Hyvärinen, Jooseppi; Fischer, Anna-Lena; Kanninen, Katja M; Gynther, Mikko; Puris, Elena, 2026, Brain research bulletin, 239, 111872. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Endoscopy-guided bilateral olfactory mucosal biopsy: a safe and reproducible outpatient technique

Muala, Ala; Buckland, Robert; Olofsson, Katarina; Penttilä, Elina; Kanninen, Katja M; Friberg, Maria, 2026, Acta oto-laryngologica, [Published online: 31 Mar 2026], 1-8. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Molecular alterations in human olfactory mucosal cells from healthy individuals and individuals with Alzheimer’s disease induced by real-world ambient air

Rossner, Pavel; Libalova, Helena; Sima, Michal; Cervena, Tereza; Simova, Zuzana; Vrbova, Kristyna; Ambroz, Antonin; Rossnerova, Andrea; Novakova, Zuzana; Elzeinova, Fatima; Vimrova, Anezka; Klema, Jiri; Koivisto, Anne M.; Penttilä, Elina; Dittrich, Lubos; Vojtisek, Michal; Pechout, Martin; Kanninen, Katja M; Vojtisek-Lom, Michal, 2026, Environmental toxicology and pharmacology, 124, 105019. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Parental Perceptions of Benefits and Risks Concerning Mental Health Biomarker Testing for Adolescents

Jadhav, Kaustubh Kishor; Kuuru, Kirsi; Aromaa, Eeva; Piironen, Aino-Kaisa; Eriksson, Päivi; Kanninen, Katja M.; Tolmunen, Tommi, 2026, Community mental health journal, [Published: 25 February 2026], 1-10. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Plasma metabolomics and red blood cell fatty acid profiles in adolescent mental health

Piironen, Aino Kaisa; Afonin, Alexey M; Zarei, Iman; Koistinen, Ville; Lehtonen, Marko; Hämäläinen, Venla; Sala-Vila, Aleix; Lázaro, Iolanda; Julvez, Jordi; van Kamp, Irene; Kanninen, Katja M, 2026, Comprehensive psychoneuroendocrinology, 26, 100347. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Plasma proteome demonstrates sex-specific associations with mental health risks in adolescents

Afonin, Alexey M; Piironen, Aino-Kaisa; Julvez, Jordi; van Kamp, Irene; Kanninen, Katja M, 2026, Psychiatry research, 358, 116980. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Polystyrene nanoplastics modulate neurite length in a size-specific manner

Górová, Veronika; Lai, Thuy Thi; Afonin, Alexey M; Nemeth, Kore; Pelkonen, Anssi; Malm, Tarja; Jalava, Pasi; Lampinen, Riikka; Kanninnen, Katja M, 2026, NanoImpact, 41, 100614. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Source-dependent temporal toxicity and transcriptomic remodeling by urban ultrafine particles: Megacity - suburban comparison in aging olfactory-brain interface

Fayad, Claire; Mussalo, Laura; Afonin, Aleksei; Lampinen, Riikka; Hakkarainen, Henri; Hensel, Anna-Katharina; Yahfoufi, Karim; Behzadpour, Donya; Penttilä, Elina; Koivisto, Anne M; Cascione, Luciano; Pennings, Sari; Mikkonen, Santtu; Jalava, Pasi; Kanninen, Katja M, 2026, Science of the total environment, 1026, 181661. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Air Pollution and the Brain

Kanninen, Katja Marika; White, Anthony Robert, 2025, Springer. D6 Toimitettu ammatillinen teos

Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases

Jakubowska, Monika; Costa, Vera Marisa; Krzeptowski, Wojciech; Dominkuš, Pia Pužar; Santos, Marlene; Demirdöğen, Birsen Can; Genç, Şermin; Trougakos, Ioannis P; Kanninen, Katja M; Winklhofer-Roob, Brigitte M; Copple, Ian M; Cuadrado, Antonio; Dolžan, Vita; Morgenstern, Christina, 2025, Redox biology, 87, 103891. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Associations between air pollution and relative leukocyte telomere length among northern Swedish adults based on findings from the Betula study

Raza, Wasif; Pudas, Sara; Kanninen, Katja M; Flanagan, Erin; Degerman, Sofie; Adolfsson, Rolf; Giugno, Rosalba; Topinka, Jan; Zeng, Xiao-wen; Oudin, Anna, 2025, Scientific reports, 15, 1, 32660. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

How Do Air Pollutants Affect the Brain? Potential Entry Routes and Peripheral Effects

Mussalo, Laura; Fayad, Claire; Shahbaz, Muhammad Ali; Puris, Elena; Kanninen, Katja Marika, 2025, Kanninen, Katja Marika; White, Anthony Robert, Air Pollution and the Brain, 41-66. B2 Kirjan tai muun kokoomateoksen osa

Importance of sub-23 nm particles in traffic environments: Particle number emission factors and extrathoracic deposition doses

Lintusaari, Henna; Lepistö, Teemu; Saarikoski, Sanna; Salo, Laura; Silvonen, Ville; Barreira, Luis M.F.; Aurela, Minna; Hoivala, Jussi; Markkula, Lassi; Ondracek, Jakub; Wahle, Tina; Vojtisek-Lom, Michal; Topinka, Jan; Schins, Roel PF; Jalava, Pasi; Timonen, Hilkka; Kanninen, Katja M; Rönkkö, Topi, 2025, Environmental pollution, 369, 125835. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia

Sitnikova, Valeriia; Nurkhametova, Dilyara; Braidotti, Nicoletta; Ciubotaru, Catalin, D; Giudice, Luca; Impola, Ulla; Kärkkäinen, Sari;Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Fagerlund, Ilkka; Kanninen, Katja, M; Zetterberg, Henrik; Kokkola, Tarja; Laitinen Saara; Koivisto, Anne; Cojoc, Dan; Giniatullin, Rashid; Malm, Tarja, M, 2025, Alzheimer's & dementia, 21, 6, e70368. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term exposure to major constituents of PM2.5 and executive function among children and adolescents in China

Chen, Hua Lian; Zeng, Qing Guo; Wei, Jing; Zhang, Qiong; Zeng, Hui Xian; Kanninen, Katja; Jalaludin, Bin; Dai, Jian; Lv, Yuan; Zhao, Bin; Jalava, Pasi; Dong, Guang Hui; Zeng, Xiao Wen, 2025, Environmental pollution, 382, 126740. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Optimisation of ultrafine particle exposure in an alveolar tri-culture model at the air-liquid interface

Hensel, Anna-Katharina; Hakkarainen, Henri; Yang, Mo; Huang, Jingwen; Mussalo, Laura; Fayad, Claire; Kanninen, Katja; Jalava, Pasi, 2025, Toxicology in vitro, 112, 106189. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Preface

Kanninen, Katja Marika; White, Anthony Robert, 2025, Kanninen, Katja Marika; White, Anthony Robert, Air Pollution and the Brain, v. B2 Kirjan tai muun kokoomateoksen osa

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Ohtonen, Sohvi; Jäntti, Henna; Giudice, Luca; Mohamed, Ahmed; Shakirzyanova, Anastasia; Závodná, Táňa; Belevich, Ilya; Yan, Hong; Sabogal-Guáqueta, Angélica María; Saveleva, Liudmila; Väänänen, Mari-Anna; Rillo-Albert, Ashley; Perciballi, Elisa; Ferrari, Daniela; Tervo, Minna-Mari; Gómez-Budia, Mireia; Krejčík, Zdeněk; Aakko-Saksa, Päivi; Koistinaho, Jari; Lehtonen, Šárka; Kanninen, Katja M.; Topinka, Jan; Jokitalo, Eija; Sierra, Alejandra; Schmidt, Martina; Dolga, Amalia M.; Jalava, Pasi I.; Ko, 2025, Environment international, 199, 109467. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

Mussalo, Laura; Afonin, Alexey M.; Zavodna, Tana; Krejcik, Zdenek; Honkova, Katerina; Fayad, Claire; Shahbaz, Muhammad Ali; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Jalava, Pasi; Lampinen, Riikka; Kanninen, Katja M, 2025, Environment international, 199, 109484. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery

Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario, 2024, Journal of drug delivery science and technology, 93, 105419. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review

Li, Shenpan; Qin, Shuangjian; Zeng, Huixian; Chou, Weichun; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guanghui; Zeng, Xiaowen, 2024, Eco-environment & health, 3, 4, 476-493. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis

Jadhav, Kaustubh Kishor; Daouk, Joud; Kurkinen, Karoliina; Kraav, Siiri-Liisi; Eriksson, Päivi; Tolmunen, Tommi; Kanninen, Katja M, 2024, Journal of affective disorders, 372, 48-55. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p

Zeng, Hui-Xian; Qin, Shuang-Jian; Wu, Qi-Zhen; Zeng, Qing-Guo; Li, Jia-Hui; Oudin, Anna; Kanninen, Katja M.; Yang, Mo; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen, 2024, Journal of hazardous materials, 484, 136719. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden

Oudin, Anna; Raza, Wasif; Flanagan, Erin; Segersson, David; Jalava, Pasi; Kanninen, Katja M.; Rönkkö, Topi; Giugno, Rosalba; Sandström, Thomas; Muala, Ala; Topinka, Jan; Sommar, Johan, 2024, Scientific reports, 14, 1, 15521. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection

Shahbaz, Muhammad Ali; Kuivanen, Suvi; Mussalo, Laura; Afonin, Alexey M; Kumari, Kajal; Behzadpour, Donya; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Jalava, Pasi; Vapalahti, Olli; Balistreri, Giuseppe; Lampinen, Riikka; Kanninen, Katja M, 2024, Environmental research, 249, 118451. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway

Petralla, Sabrina; Saveleva, Liudmila; Kanninen, Katja M; Oster, Julia S; Panayotova, Maria; Fricker, Gert; Puris, Elena, 2024, Molecular neurobiology, 61, 9, 6383-6394. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

Drouard, Gabin; Wang, Zhiyang; Heikkinen, Aino; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M.; van Kamp, Irene; Pirinen, Matti; Ollikainen, Miina; Kaprio, Jaakko, 2024, Scientific reports, 14, 1, 21261. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China

Wu, Qi-Zhen; Zeng, Hui-Xian; Andersson, John; Oudin, Anna; Kanninen, Katja M.; Xu, Mu-Wu; Qin, Shuang-Jian; Zeng, Qing-Guo; Zhao, Bin; Zheng, Mei; Jin, Nanxiang; Chou, Wei-Chun; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen, 2024, Journal of hazardous materials, 470, 134161. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort

Raza, Wasif; Öhman, Anders; Kanninen, Katja M; Jalava, Pasi; Zeng, Xiao-wen; de Crom, Tosca OE; Ikram, M Arfan; Oudin, Anna, 2024, Frontiers in public health, 12, 1401006. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework

Qin, Shuang-Jian; Zeng, Qing-Guo; Zeng, Hui-Xian; Li, Shen-Pan; Andersson, John; Zhao, Bin; Oudin, Anna; Kanninen, Katja M; Jalava, Pasi; Jin, Nan-Xiang; Yang, Mo; Lin, Li-Zi; Liu, Ru-Qing; Dong, Guang-Hui; Zeng, Xiao-Wen, 2024, Science of the total environment, 947, 174450. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Jäntti, Henna; Jonk, Steffi; Gómez Budia, Mireia; Ohtonen, Sohvi; Fagerlund, Ilkka; Fazaludeen, Mohammad Feroze; Aakko-Saksa, Päivi; Pebay, Alice; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Jalava, Pasi I; Malm, Tarja; Korhonen, Paula, 2024, Particle and fibre toxicology, 21, 1, 6. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Proteomic insights into mental health status: plasma markers in young adults

Afonin, Alexey M; Piironen, Aino-Kaisa; de Sousa Maciel, Izaque; Ivanova, Mariia; Alatalo, Arto; Whipp, Alyce M; Pulkkinen, Lea; Rose, Richard J; van Kamp, Irene; Kaprio, Jaakko; Kanninen, Katja M, 2024, Translational psychiatry, 14, 1, 55. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert, 2024, Frontiers in pharmacology, 15, 1365051. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The association between oral diseases and neurodegenerative disorders

Soiniemi, Lauriina; Solje, Eino; Suominen, Anna Liisa; Kanninen, Katja M; Kullaa, Arja M, 2024, Journal of Alzheimer's disease, 102, 3, 577-586. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

The emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review

Zeng, Hui-Xian; Qin, Shuang-Jian; Andersson, John; Li, Shen-Pan; Zeng, Qing-Guo; Li, Jia-Hui; Wu, Qi-Zhen; Meng, Wen-Jie; Oudin, Anna; Kanninen, Katja M.; Jalava, Pasi; Dong, Guang-Hui; Zeng, Xiao-Wen, 2024, Environmental pollution, 366, 125440. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Mussalo, Laura; Lampinen, Riikka; Avesani, Simone; Závodná, Táňa; Krejčík, Zdeněk; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Jalava, Pasi; Kanninen, Katja M, 2024, Redox biology, 75, 103272. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Saveleva, Liudmila; Cervena, Tereza; Mengoni, Claudia; Sima, Michal; Krejcik, Zdenek; Vrbova, Kristyna; Sikorova, Jitka; Mussalo, Laura; de Crom, Tosca O E; Šímová, Zuzana; Ivanova, Mariia; Shahbaz, Muhammad Ali; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Ikram, M Arfan; Jalava, Pasi I; Malm, Tarja; Chew, Sweelin; Vojtisek‐Lom, Michal; Topinka, Jan; Giugno, Rosalba; Rössner, Pavel; Kanninen, Katja M, 2024, Alzheimer's & dementia, 20, 12, 8825-8843. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

Ivanova, Mariia; Belaya, Irina; Kucháriková, Nina; de Sousa Maciel, Izaque; Saveleva, Liudmila; Alatalo, Arto; Juvonen, Ilona; Thind, Navjot; Andrès, Clarisse; Lampinen, Riikka; Chew, Sweelin; Kanninen, Katja M, 2024, Neurobiology of disease, 191, 106410. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Adopting a child perspective for exposome research on mental health and cognitive development - Conceptualisation and opportunities

Person Waye, Kerstin; Löve, Jesper; Lercher, Peter; Dzhambov, Angel M.; Klatte, Maria; Schreckenberg, Dirk; Belke, Christin; Leist, Larisa; Ristovska, Gordana; Jeram, Sonja; Kanninen, Katja M.; Selander, Jenny; Arat, Arzu; Lachmann, Thomas; Clark, Charlotte; Botteldooren, Dick; White, Kim; Julvez, Jordi; Foraster, Maria; Kaprio, Jaakko; Bolte, Gabriele; Psyllidis, Achilleas; Gulliver, John; Boshuizen, Hendriek; Bozzon, Alessandro; Fels, Janina; Hornikx, Maarten; van den Hazel, Peter; Weber, Miri, 2023, Environmental research, 239, Part 1, 117279. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja, 2023, Journal of extracellular vesicles, 12, 1, 12297. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Mussalo, Laura; Avesani, Simone; Shahbaz, Muhammad Ali; Zavodna, Tana; Saveleva, Liudmila; Järvinen, Anssi; Lampinen, Riikka; Belaya, Irina; Krejcik, Zdenek; Ivanova, Mariia; Hakkarainen, Henri; Kalapudas, Juho; Penttilä, Elina; Löppönen, Heikki; Koivisto, Anne M; Malm, Tarja; Topinka, Jan; Giugno, Rosalba; Aakko-Saksa, Päivi; Chew, Sweelin; Rönkkö, Topi; Jalava, Pasi; Kanninen, Katja M, 2023, Science of the total environment, 905, 167038. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Exploring plasma biomarker candidates for mental health risk assessment in adolescents

Piironen, Aino-Kaisa; Kanninen, Katja, 2023, Nature mental health, 1, 8, 532-533. B1 Kirjoitus tieteellisessä aikakauslehdessä

Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa

Shahbaz, Muhammad Ali; Kuivanen, Suvi; Lampinen, Riikka; Mussalo, Laura; Hron, Tomáš; Závodná, Táňa; Ojha, Ravi; Krejčík, Zdeněk; Saveleva, Liudmila; Tahir, Numan Ahmad; Kalapudas, Juho; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Singh, Prateek; Topinka, Jan; Vapalahti, Olli; Chew, Sweelin; Balistreri, Giuseppe; Kanninen, Katja M, 2023, Journal of neuroinflammation, 20, 1, 299. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Drouard, Gabin; Hagenbeek, Fiona A; Whipp, Alyce M.; Pool, René; Hottenga, Jouke Jan; Jansen, Rick; Hubers, Nikki; Afonin, Aleksei; Willemsen, Gonneke; de Geus, Eco JC; Ripatti, Samuli; Pirinen, Matti; Kanninen, Katja M; Boomsma, Dorret I; van Dongen, Jenny; Kaprio, Jaakko, 2023, Bmc medicine, 21, 1, 508. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Plasma proteomics discovery of mental health risk biomarkers in adolescents

de Sousa Maciel, Izaque; Piironen, Aino-Kaisa; Afonin, Alexey M; Ivanova, Mariia; Alatalo, Arto; Jadhav, Kaustubh Kishor; Julvez, Jordi; Foraster, Maria; van Kamp, Irene; Kanninen, Katja M, 2023, Nature mental health, 1, 8, 596-605. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity

Dzhambov, Angel M; Lercher, Peter; Vincens, Natalia; Persson Waye, Kerstin; Klatte, Maria; Leist, Larisa; Lachmann, Thomas; Schreckenberg, Dirk; Belke, Christin; Ristovska, Gordana; Kanninen, Katja M; Botteldooren, Dick; Van Renterghem, Timothy; Jeram, Sonja; Selander, Jenny; Arat, Arzu; White, Kim; Julvez, Jordi; Clark, Charlotte; Foraster, Maria; van Kamp, Irene, 2023, Environmental research, 233, 116452. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

Alatalo, Arto; de Sousa Maciel, Izaque; Kucháriková, Nina; Chew, Sweelin; van Kamp, Irene; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M, 2023, Biomedicines, 11, 3, 818. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

Saveleva, Liudmila; Sima, Michal; Klema, Jiri; Krejčík, Zdeněk; Vartiainen, Petra; Sitnikova, Valeriia; Belaya, Irina; Malm, Tarja; Jalava, Pasi I; Rössner, Pavel; Kanninen, Katja M, 2023, Environmental toxicology and pharmacology, 104, 104316. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

9th Kuopio Alzheimer Symposium and 3rd Nordic Memory Clinic Conference: Program and Abstracts

Kanninen, Katja; Górová, Veronika, 2022, Itä-Suomen yliopisto. D6 Toimitettu ammatillinen teos

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M, 2022, Environmental toxicology and pharmacology, 96, 104003. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition

Rantanen, Laura M.; Bitar, Maina; Lampinen, Riikka; Stewart, Romal; Quek, Hazel; Oikari, Lotta E.; Cunί-Lόpez, Carla; Sutharsan, Ratneswary; Thillaiyampalam, Gayathri; Iqbal, Jamila; Russell, Daniel; Penttilä, Elina; Löppönen, Heikki; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Koivisto, Anne M.; Haupt, Larisa M.; Mackay-Sim, Alan; Cristino, Alexandre S.; Kanninen, Katja M.; White, Anthony R., 2022, Cells, 11, 20, 3258. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients

Lampinen, Riikka; Górová, Veronika; Avesani, Simone; Liddell, Jeffrey R; Penttilä, Elina; Závodná, Táňa; Krejčík, Zdeněk; Lehtola, Juha-Matti; Saari, Toni; Kalapudas, Juho; Hannonen, Sanna; Löppönen, Heikki; Topinka, Jan; Koivisto, Anne M; White, Anthony R; Giugno, Rosalba; Kanninen, Katja M, 2022, International journal of molecular sciences, 23, 8, 4123. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Early environmental quality and life-course mental health effects: The Equal-Life project

Kamp, Irene van; Persson Waye, Kerstin; Kanninen, Katja; Gulliver, John; Bozzon, Alessandro; Psyllidis, Achilleas; Boshuizen, Hendriek; Selander, Jenny; van den Hazel, Peter; Brambilla, Marco; Foraster, Maria; Julvez, Jordi; Klatte, Maria; Jeram, Sonja; Lercher, Peter; Botteldooren, Dick; Ristovska, Gordana; Kaprio, Jaakko; Schreckenberg, Dirk; Hornikx, Maarten; Fels, Janina; Weber, Miriam; Braat-Eggen, Ella; Hartmann, Julia; Clark, Charlotte; Vrijkotte, Tanja; Brown, Lex; Bolte, Gabriele; Equal, 2022, Environmental epidemiology, 6, 1, e183. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena, 2022, Pharmaceutics, 14, 11, 2438. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Doccini, Stefano; Marchese, Maria; Morani, Federica; Gammaldi, Nicola; Mero, Serena; Pezzini, Francesco; Soliymani, Rabah; Santi, Melissa; Signore, Giovanni; Ogi, Asahi; Rocchiccioli, Silvia; Kanninen, Katja M.; Simonati, Alessandro; Lalowski, Maciej M.; Santorelli, Filippo M., 2022, Cells, 11, 11, 1840. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework

Shahbaz, Muhammad Ali; De Bernardi, Francesca; Alatalo, Arto; Sachana, Magdalini; Clerbaux, Laure-Alix; Muñoz, Amalia; Parvatam, Surat; Landesmann, Brigitte; Kanninen, Katja M.; Coecke, Sandra, 2022, Cells, 11, 19, 3027. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko, 2022, Neuroscience, 496, 165-178. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Microglial amyloid beta clearance is driven by PIEZO1 channels

Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja, 2022, Journal of neuroinflammation, 19, 1, 147. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R; Rait, Dzhessi; Huuskonen, Mikko T; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R; Marsh-Armstrong, Nicholas; Kanninen, Katja M, 2022, Neurobiology of disease, 170, 105753. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Choo, Xin Yi; McInnes, Lachlan E; Grubman, Alexandra; Wasielewska, Joanna M; Belaya, Irina; Burrows, Emma; Quek, Hazel; Martín, Jorge Cañas; Loppi, Sanna; Sorvari, Annika; Rait, Dzhessi; Powell, Andrew; Duncan, Clare; Liddell, Jeffrey R.; Tanila, Heikki; Polo, Jose M; Malm, Tarja; Kanninen, Katja M.; Donnelly, Paul S; White, Anthony R, 2022, International journal of molecular sciences, 23, 18, 10722. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease

Puris, Elena; Saveleva, Liudmila; de Sousa Maciel, Izaque; Kanninen, Katja M.; Auriola, Seppo; Fricker, Gert, 2022, Molecular neurobiology, 60, 2, 732-748. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Lampinen, Riikka; Fazaludeen, Mohammad Feroze; Avesani, Simone; Örd, Tiit; Penttilä, Elina; Lehtola, Juha-Matti; Saari, Toni; Hannonen, Sanna; Saveleva, Liudmila; Kaartinen, Emma; Fernández Acosta, Francisco; Cruz-Haces, Marcela; Löppönen, Heikki; Mackay-Sim, Alan; Kaikkonen, Minna U; Koivisto, Anne M; Malm, Tarja; White, Anthony R; Giugno, Rosalba; Chew, Sweelin; Kanninen, Katja M, 2022, Cells, 11, 4, 676. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Saveleva, Liudmila; Vartiainen, Petra; Górová, Veronika; Chew, Sweelin; Belaya, Irina; Konttinen, Henna; Zucchelli, Martina; Korhonen, Paula; Kaartinen, Emma; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Kanninen, Katja M, 2022, Neurotoxicology, 89, 55-66. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko, 2022, Brain disorders, 6, 100035. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

Martikainen, Maria-Viola; Aakko-Saksa, Päivi; van den Broek, Lenie; Cassee, Flemming R; Carare, Roxana O; Chew, Sweelin; Dinnyes, Andras; Giugno, Rosalba; Kanninen, Katja M; Malm, Tarja; Muala, Ala; Nedergaard, Maiken; Oudin, Anna; Oyola, Pedro; Pfeiffer, Tobias V; Rönkkö, Topi; Saarikoski, Sanna; Sandström, Thomas; Schins, Roel PF; Topinka, Jan; Yang, Mo; Zeng, Xiaowen; Westerink, Remco HS; Jalava, Pasi I, 2022, International journal of environmental research and public health, 19, 1, 311. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19

Hogberg, Helena T.; Lam, Ann; Ohayon, Elan; Shahbaz, Muhammad Ali; Clerbaux, Laure-Alix; Bal-Price, Anna; Coecke, Sandra; Concha, Rachel; De Bernardi, Francesca; Edrosa, Eizleayne; Hargreaves, Alan J.; Kanninen, Katja M.; Munoz, Amalia; Pistollato, Francesca; Saravanan, Surat; Garcia-Reyero, Natàlia; Wittwehr, Clemens; Sachana, Magdalini, 2022, Cells, 11, 21, 3411. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Keuters, Meike Hedwig; Keksa-Goldsteine, Velta; Dhungana, Hiramani; Huuskonen, Mikko T; Pomeshchik, Yuriy; Savchenko, Ekaterina; Korhonen, Paula K; Singh, Yajuvinder; Wojciechowski, Sara; Lehtonen, ¦árka; Kanninen, Katja M; Malm, Tarja; Sirviö, Jouni; Muona, Anu; Koistinaho, Milla; Goldsteins, Gundars; Koistinaho, Jari, 2021, Scientific reports, 11, 1, 3518. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased iron content in the heart of the Fmr1 knockout mouse

Talvio, Karo; Kanninen, Katja M; White, Anthony R; Koistinaho, Jari; Castrén, Maija L, 2021, Biometals, 34, 4, 947-954. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Puris, Elena; Kouril, ¦tepán; Najdekr, Luká¨; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Friedecký, David; Gynther, Mikko, 2021, Scientific reports, 11, 1, 13076. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Belaya, Irina; Kucháriková, Nina; Górová, Veronika; Kysenius, Kai; Hare, Dominic J.; Crouch, Peter J.; Malm, Tarja; Atalay, Mustafa; White, Anthony R.; Liddell, Jeffrey R.; Kanninen, Katja M., 2021, International journal of molecular sciences, 22, 16, 8715. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko, 2021, Journal of pharmaceutical sciences, 110, 12, 3953-3962. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Belaya, Irina; Ivanova, Mariia; Sorvari, Annika; Ilicic, Marina; Loppi, Sanna; Koivisto, Hennariikka; Varricchio, Alessandra; Tikkanen, Heikki; Walker, Frederick R; Atalay, Mustafa; Malm, Tarja; Grubman, Alexandra; Tanila, Heikki; Kanninen, Katja M, 2020, Journal of neuroinflammation, 17, 1, 271. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, RO; Aldea, R; Agarwal, N; Bacskai, BJ; Bechman, I; Boche, D; Bu, G; Bulters, D; Clemens, A; Counts, SE; de Leon, M; Eide, PK; Fossati, S; Greenberg, SM; Hamel, E; Hawkes, CA; Koronyo-Hamaoui, M; Hainsworth, AH; Holtzman, D; Ihara, M; et al [incl. Kanninen, K; Leinonen, V; Malm, T], 2020, Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 21, 1, e12053. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Editorial: Air Pollution and Brain Health

White, Anthony; Kanninen, Katja; Malm, Tarja; Schins, Roel, 2020, Neurochemistry international, 141, 104900. B1 Kirjoitus tieteellisessä aikakauslehdessä

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Gómez-Budia, Mireia; Konttinen, Henna; Saveleva, Liudmila; Korhonen, Paula; Jalava, Pasi; Kanninen, Katja; Malm, Tarja, 2020, Neurochemistry international, 136, 104715. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Impairment of mitochondrial function by particulate matter: Implications for the brain

Chew, S; Kolosowska, N; Saveleva, L; Malm, T; Kanninen, KM, 2020, Neurochemistry international, 135, 104694. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Kolosowska, Natalia; Gotkiewicz, Maria; Dhungana, Hiramani; Giudice, Luca; Giugno, Rosalba; Box, Daphne; Huuskonen, Mikko T.; Korhonen, Paula; Scoyni, Flavia; Kanninen, Katja M.; Ylä-Herttuala, Seppo; Turunen, Tiia A.; Turunen, Mikko P.; Koistinaho, Jari; Malm, Tarja, 2020, Journal of neuroinflammation, 17, 194. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Olfactory cell cultures to investigate health effects of air pollution exposure: implications for neurodegeneration

Kanninen, KM; Lampinen, R; Rantanen, LM; Odendaal, L; Jalava, P; Chew, S; White, AR, 2020, Neurochemistry international, 136, 104729. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals

Loppi, Sanna; Korhonen, Paula; Bouvy-Liivrand, Maria; Cagliola, Simone; Turunen, Tiia A; Turunen, Mikko P; Hernandez de Sande, Ana; Kolosowska, Natalia; Scoyni, Flavia; Rosell, Anna; García-Berrocoso, Teresa; Lemarchant, Sighild; Dhungana, Hiramani; Montaner, Joan; Koistinaho, Jari; Kanninen, Katja M; Kaikkonen, Minna U; Giugno, Rosalba; Heinäniemi, Merja; Malm, Tarja, 2020, Aging cell, 2021; 20, 1, e13287. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Proteomic and functional analyses in disease models reveal CLN5 protein involvement in mitochondrial dysfunction

Doccini, S; Morani, F; Nesti, C; Pezzini, F; Calza, G; Soliymani, R; Signore, G; Rocchiccioli, S; Kanninen, KM; Huuskonen, MT; Baumann, MH; Simonati, A; Lalowski, MM; Santorelli, FM, 2020, Cell death discovery, 6, 1, 18. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

Chew, Sweelin; Lampinen, Riikka; Saveleva, Liudmila; Korhonen, Paula; Mikhailov, Nikita; Grubman, Alexandra; Polo, Jose M; Wilson, Trevor; Komppula, Mika; Rönkkö, Teemu; Gu, Cheng; Mackay-Sim, Alan; Malm, Tarja; White, Anthony R; Jalava, Pasi; Kanninen, Katja M, 2020, Particle and fibre toxicology, 17, 1, 18. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Korhonen, P; Pollari, E; Kanninen, KM; Savchenko, E; Lehtonen, ¦; Wojciechowski; S; Pomeshchik, Y; Van Den Bosch, L; Goldsteins, G; Koistinaho, J; Malm, T, 2019, IBRO reports, 6, 74-86. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Singh, Y; Leinonen, H; Fazaludeen, F; Jaronen, M; Guest, D; Buckley, N; Byts, N; Oksa, P; Jalkanen, K; Iqbal, I; Huuskonen, M; Savchenko, E; Keksa-Goldsteine, V; Chew, S; Myllyharju, J; Tanila, H; Ooi, L; Koistinaho, J; Kanninen, KM; Malm, T, 2019, Human molecular genetics, 28, 11, 3309-3322. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes

Oksanen, M; Hyötyläinen, I; Trontti, K; Rolova, T; Wojciechowski, S; Koskuvi, M; Viitanen, M; Levonen, AL; Hovatta, I; Roybon, L; Lehtonen, ¦; Kanninen, KM; Hämäläinen, RH; Koistinaho, J, 2019, Glia, 2020; 68, 3, 589-599. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Konttinen, H; Cabral-da-Silva, MEC; Ohtonen, S; Wojciechowski, S; Shakirzyanova, A; Caligola, S; Giugno, R; Ishchenko, Y; Hernández, D; Fazaludeen, MF; Eamen, S; Budia, MG; Fagerlund, I; Scoyni, F; Korhonen, P; Huber, N; Haapasalo, A; Hewitt, AW; Vickers, J; Smith, GC; et al., 2019, Stem cell reports, 13, 4, 669-683. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko, 2018, Pharmaceutical research, 2019; 36, 17. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

CuII(atsm) Attenuates Neuroinflammation

Choo, Xin Yi; Liddell, Jeffrey R; Huuskonen, Mikko T; Grubman, Alexandra; Moujalled, Diane; Roberts, Jessica; Kysenius, Kai; Patten, Lauren; Quek, Hazel; Oikari, Lotta E; Duncan, Clare; James, Simon A; McInnes, Lachlan E; Hayne, David J; Donnelly, Paul S; Pollari, Eveliina; Vähätalo, Suvi; Lejavová, Katarína; Kettunen, Mikko I; Malm, Tarja; et al. [Incl Koistinaho, Jari; Kanninen, Katja], 2018, Frontiers in neuroscience, 12, 668. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T, 2018, Brain behavior and immunity, 73, 670-681. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Long-term exercise protects against cellular stresses in aged mice

Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja; Atalay, Mustafa; Kumagai, Shuzo, 2018, Oxidative medicine and cellular longevity, 2018, 2894247. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Mitochondrial Function in Alzheimer's Disease: Focus on Astrocytes

Lampinen, Riikka; Belaya, Irina; Boccuni, Isabella; Malm, Tarja; Kanninen, Katja M, 2018, Gentile, Maria Teresa, Astrocyte: Physiology and Pathology, 139-162. A3 Kirjan tai muun kokoomateoksen osa

PPARß/DELTA-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1deltaE9 astrocytes

Konttinen, H; Gureviciene, I; Oksanen, M; Grubman, A; Loppi, S; Huuskonen, MT; Korhonen, P; Lampinen, R; Keuters, M; Belaya, I; Tanila, H; Kanninen, KM; Goldsteins, G; Landreth, G; Koistinaho, J; Malm, T, 2018, Glia, 2019; 67, 1, 146-159. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Abdalkader, Moataz; Lampinen, Riikka; Kanninen, Katja M; Malm, Tarja M; Liddell, Jeffrey R, 2018, Frontiers in neuroscience, 12, 466. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases

Kanninen Katja M, White Anthony R, 2017, White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I, Biometals in neurodegenerative diseases : mechanisms and therapeutics, 415-438. A3 Kirjan tai muun kokoomateoksen osa

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease

Vellonen KS, Ihalainen J, Boucau M-C, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M, 2017, Pharmaceutical research, 34, 12, 2652-2662. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatilloa O, Sallinen J, Ndode-Ekanea XE, Pitkänen A, 2017, Epilepsy research, 136, 18-34. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Lack of collagen XV is protective after ischemic stroke in mice

Dhungana Hiramani, Huuskonen Mikko T, Pihlajaniemi Taina, Heljasvaara Ritva, Vivien Denis, Kanninen Katja M, Malm Tarja, Koistinaho Jari, Lemarchant Sighild, 2017, Cell death and disease, 8, January, 1-8. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Loss of CLN5 causes altered neurogenesis in a childhood neurodegenerative disorder

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm TM, Koistinaho J, Kanninen KM, 2017, Disease models and mechanisms, 10, 9, 1089-1100. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Metals and lysosomal storage disorders

Konttinen Henna, Lejavová Katarína, Malm Tarja, Kanninen Katja M, 2017, White Anthony R, Aschner Michael, Costa Lucio G, Bush Ashley I, Biometals in neurodegenerative diseases : mechanisms and therapeutics, 195-215. A3 Kirjan tai muun kokoomateoksen osa

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen ¦, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J, 2017, Stem cell reports, 9, 6, 1885-1897. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M, 2017, Scientific reports, 7, 1597. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T, 2017, Journal of neuroinflammation, 14, 11, 237. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Huuskonen, MT; Tuo, QZ; Loppi, S; Dhungana, H; Korhonen, P; McInnes, LE; Donnelly, PS; Grubman, A; Wojciechowski, S; Lejavova, K; Pomeshchik, Y; Periviita, L; Kosonen, L; Giordano, M; Walker, FR; Liu, R; Bush, AI; Koistinaho, J; Malm, T; White, AR; et al., 2017, Neurotherapeutics, 14, 2, 519-532. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'

Kanninen KM, White AR, 2017, Journal of neurochemistry, 141, 1, 9-11. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 10. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J, 2016, Glia, 64, 9, 1492-507. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM, 2016, Scientific reports, 6, 33176. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Eksosomit aivosairauksissa - solujenvälisen kommunikoinnin uusi muoto

Kanninen K, Malm T, 2016, Duodecim, 132, 21, 1957-63. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J, 2016, Molecular neurodegeneration, 11, 15. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Exosomes in Alzheimer's disease

Malm Tarja, Loppi Sanna, Kanninen Katja M, 2016, Neurochemistry international, 97, 193-199. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets

Grubman Alexandra, Kanninen Katja M, Malm Tarja, 2016, Journal of molecular neuroscience, 60, 3, 390-404. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Liddell Jeffrey R, Lehtonen Sarka, Duncan Clare, Keksa-Goldsteine Velta, Levonen Anna-Liisa, Goldsteins Gundars, Malm Tarja, White Anthony R, Koistinaho Jari, Kanninen Katja M, 2016, Journal of neuroinflammation, 13, 49, 1-14. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Applications of the Keap1-Nrf2 system for gene and cell therapy

Kanninen Katja M, Pomeshchik Yuriy, Leinonen Hanna, Malm Tarja, Koistinaho Jari, Levonen Anna-Liisa, 2015, Free radical biology and medicine, 88, Part B, 350-361. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage

Rolova Taisia, Dhungana Hiramani, Korhonen Paula, Valonen Piia, Kolosowska Natalia, Konttinen Henna, Kanninen Katja, Tanila Heikki, Malm Tarja, Koistinaho Jari, 2015, Aging and disease, [epub ahead of print 3 Dec 2015]. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Editorial: Metals and neurodegeneration: restoring the balance

White Anthony R, Kanninen Katja M, Crouch Peter J, 2015, Frontiers in aging neuroscience, 7, 127. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Exosomes as new diagnostic tools in CNS diseases

Kanninen Katja M, Bister Nea, Koistinaho Jari, Malm Tarja, 2015, Biochimica et biophysica acta: molecular basis of disease, 2016; 1862, 3, 403-410. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Korhonen Paula, Kanninen Katja M, Lehtonen Sarka, Lemarchant Sighild, Puttonen Katja A, Oksanen Minna, Dhungana Hiramani, Loppi Sanna, Pollari Eveliina, Wojciechowski Sara, Kidin Iurii, Garcia-Berrocoso Teresa, Giralt Dolors, Montaner Joan, Koistinaho Jan I, Malm Tarja, 2015, Brain behavior and immunity, 49, 322-336. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Grubman Alexandra, Pollari Eveliina, Duncan Clare, Caragounis Aphrodite, Blom Tea, Volitakis Irene, Wong Andrew, Cooper Jonathan, Crouch Peter J, Koistinaho Jari, Jalanko Anu, White Anthony R, Kanninen Katja M, 2014, Metallomics, 2014 Apr;6(4), 932-943. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Grubman Alexandra, Lidgerwood Grace E, Duncan Clare, Bica Laura, Tan Jiang-Li, Parker Sarah J, Caragounis Aphrodite, Meyerowitz Jodi, Volitakis Irene, Moujalled Diane, Liddell Jeffrey R, Hickey James L, Horne Malcolm, Longmuir Shoshanah, Koistinaho Jari, Donnelly Paul S, Crouch Peter J, Tammen Imke, White Anthony R, Kanninen Katja M, 2014, Acta neuropathologica communications, 2014 Feb 28:2:25. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T, 2014, Brain behavior and immunity, 2014 Aug 18 ePub ahead of print. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nrf2 regulates neurogenesis and protects neural progenitor cells against aß toxicity

Kärkkäinen Virve, Pomeshchik Yuriy, Savchenko Ekaterina, Dhungana Hiramani, Kurronen Antti, Lehtonen Sarka, Naumenko Nikolay, Tavi Pasi, Levonen Anna-Liisa, Yamamoto Masayaki, Malm Tarja, Magga Johanna, Kanninen Katja M, Koistinaho Jari, 2014, Stem cells, 32, 7, 1904-1916. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

Roberts Blaine R, Lim Nastasia KH, McAllum Erin J, Donnelly Paul S, Hare Dominic J, Doble Philip A, Turner Bradley J, Price Katherine A, Lim Sin Chun, Paterson Brett M, Hickey James L, Rhoads Timothy W, Williams Jared R, Kanninen Katja M, Hung Lin W, Liddell Jeffrey R, Grubman Alexandra, Monty Jean-Francois, Llanos Roxana M, Kramer David R, Mercer Julian FB, Bush Ashley I, Masters Colin L, Duce James A, Li Qiao-Xin, Beckman Joseph S, Barnham Kevin J, White Anthony R, Crouch Peter J, 2014, Journal of neuroscience, 2014 Jun 4;34(23), 8021-8031. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Moujalled Diane, James Janine L, Yang Shu, Zhang Katharine, Duncan Clare, Moujalled Donia M, Parker Sarah J, Caragounis Aphrodite, Lidgerwood Grace, Turner Bradley J, Atkin Julie D, Grubman Alexandra, Liddell Jeffrey R, Proepper Christian, Boeckers Tobias M, Kanninen Katja M, Blair Ian, Crouch Peter J, White Anthony R, 2014, Human molecular genetics, 2015; 24, 6, 1655-1669. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge MD, White AR, 2014, Chemical science, 2014 Jun;5(6), 2503-2516. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

ADAMTS proteoglycanases in the physiological and pathological central nervous system

Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J, 2013, Journal of neuroinflammation, 2013 Oct 31;10(1), 133. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Biometals in rare neurodegenerative disorders of childhood

Parker SJ, Koistinaho J, White AR, Kanninen KM, 2013, Frontiers in aging neuroscience, 5, 14, x-x. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T, 2013, Neurobiology of disease, [Epub ahead of print], 64C, 16-29. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?

Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J, 2013, Antioxidants and redox signaling, 2013 Aug 20. [Epub ahead of print], x-x. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR, 2013, PLoS ONE, 8, 3, e58644. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR, 2013, PLoS ONE, 8(6): e67433., e67433. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo

Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J, 2012, World journal of neuroscience, 2/2012, 57-67. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis

Pollari Eveliina, Savchenko Ekaterina, Jaronen Merja, Kanninen Katja, Malm Tarja, Wojciechowski Sara, Ahtoniemi Toni, Goldsteins Gundars, Giniatullina Raisa, Giniatullin Rashid, Koistinaho Jari, Magga Johanna, 2011, Journal of neuroinflammation, 84, 1-14. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Targeting Glycogen Synthase Kinase-3&#946 for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway

Kanninen K, White AR, Koistinaho J, Malm T, 2011, International journal of alzheimer's disease, 2011;2011:985085. Epub 2011 May 2. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

Malm T, Koistinaho J, Kanninen K, 2011, International journal of alzheimer's disease, 2011;2011:517160. Epub 2011 Oct 30. A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J, 2009, Proceedings of the National Academy of Sciences of the United States of America, 106, 38, 16505-16510. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Nrf2 in Alzheimer's Disease

Kanninen K, 2009, Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. G5 Artikkeliväitöskirja

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J, 2008, Molecular and cellular neuroscience, 39, 3, 302-313. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J, 2007, Journal of neuroscience, 27, 14, 3712-3721. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A, Koistinaho J, 2007, Molecular pharmacology, 71, 30-37. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Beta-amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits

Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen T-K, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, 2006, Proceedings of the National Academy of Sciences of the United States of America, 103, 23, 8852-8857. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

The Eleventh Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2006. Abstracts

Keinänen R, Huttunen J, Häkkinen S-K, Kanninen K, Lipponen A, Louhivuori L, Mäkelä K, Mäntylä T, Tusa M, 2006, -. C2 Toimitettu teos

Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach

Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J, 2004, Neuroscience letters, 367, 2, 235-240. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Tarkenna hakuasi

Tutkimusryhmät

Projektit

Avainsanat

Characterisation of a patient-derived iPSC-based model for studying the blood-brain barrier in Alzheimer’s disease

Endoscopy-guided bilateral olfactory mucosal biopsy: a safe and reproducible outpatient technique

Molecular alterations in human olfactory mucosal cells from healthy individuals and individuals with Alzheimer’s disease induced by real-world ambient air

Parental Perceptions of Benefits and Risks Concerning Mental Health Biomarker Testing for Adolescents

Plasma metabolomics and red blood cell fatty acid profiles in adolescent mental health

Plasma proteome demonstrates sex-specific associations with mental health risks in adolescents

Polystyrene nanoplastics modulate neurite length in a size-specific manner

Source-dependent temporal toxicity and transcriptomic remodeling by urban ultrafine particles: Megacity - suburban comparison in aging olfactory-brain interface

Air Pollution and the Brain

Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases

Associations between air pollution and relative leukocyte telomere length among northern Swedish adults based on findings from the Betula study

How Do Air Pollutants Affect the Brain? Potential Entry Routes and Peripheral Effects

Importance of sub-23 nm particles in traffic environments: Particle number emission factors and extrathoracic deposition doses

Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia

Long-term exposure to major constituents of PM2.5 and executive function among children and adolescents in China

Optimisation of ultrafine particle exposure in an alveolar tri-culture model at the air-liquid interface

Preface

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery

Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review

Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis

Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p

Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden

Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection

Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China

Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort

Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework

Particulate matter from car exhaust alters function of human iPSC-derived microglia

Proteomic insights into mental health status: plasma markers in young adults

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

The association between oral diseases and neurodegenerative disorders

The emerging roles of particulate matter-changed non-coding RNAs in the pathogenesis of Alzheimer's disease: A comprehensive in silico analysis and review

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells – Implications for Alzheimer's disease

Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer's disease both in vitro and in population-based data

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

Adopting a child perspective for exposome research on mental health and cognitive development - Conceptualisation and opportunities

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

Exploring plasma biomarker candidates for mental health risk assessment in adolescents

Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Plasma proteomics discovery of mental health risk biomarkers in adolescents

Protective effect of restorative possibilities on cognitive function and mental health in children and adolescents: A scoping review including the role of physical activity

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

Transcriptomic Alterations in the Olfactory Bulb Induced by Exposure to Air Pollution: Identification of Potential Biomarkers and Insights into Olfactory System Function

9th Kuopio Alzheimer Symposium and 3rd Nordic Memory Clinic Conference: Program and Abstracts

Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer’s Disease Patients

Early environmental quality and life-course mental health effects: The Equal-Life project

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Mechanistic Understanding of the Olfactory Neuroepithelium Involvement Leading to Short-Term Anosmia in COVID-19 Using the Adverse Outcome Pathway Framework

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Microglial amyloid beta clearance is driven by PIEZO1 channels

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer’s Disease Patients

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

TUBE Project: Transport-Derived Ultrafines and the Brain Effects

The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Increased iron content in the heart of the Fmr1 knockout mouse

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model

Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease

Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Editorial: Air Pollution and Brain Health

Glial smog: Interplay between air pollution and astrocyte-microglia interactions