Etusivu
Ihmiset
Tutkimusryhmät
Projektit
Tietoa

Kirjaudu

Suomi English

Etusivu
Ihmiset
Tutkimusryhmät
Projektit
Tietoa

Sulje

Tarkenna hakuasi

Etusivu
Ihmiset
Mervi Hyvönen

Mervi Hyvönen

Apurahatutkija

FT, Molekyylilääketieteen dosentti

Farmasian laitos, Terveystieteiden tiedekunta

[email protected]

Tiedot Julkaisut

Työskentelen Professori Jouko Vepsäläisen johtamassa ja Suomen Akatemian rahoittamassa arktisen tutkimuksen akatemiaohjelmassa. Projektin yhteistyökumppaninamme toimii Professori Alex R. Khomutov Moskovan Engelhardt-instituutista. ”Muuttuva arktinen ilmasto, muuttuvat taudit”-teemaan liittyvässä hankkeessa ”Biogeeniset amiinit ja terveys arktisessa ilmastonmuutoksessa” (Biogenic amines in the health challenge caused by the changing arctic climate; ABIOHEALTH) selvitetään polyamiinien toimintaa ja merkitystä ilmastonmuutoksen aiheuttamissa ympäristötekijä- ja tautiperäisissä stressireaktioissa. Tutkimus tähtää uusien kokeellisten lääkeaineiden kehittämiseen ilmastonmuutoksen seurauksena yleistyviä sairauksia ja patogeenisiä mikro-organismeja vastaan arktisella alueella.

Tutkimusryhmät

Soveltava kemia 01.01.2012 -

Avainsanat

arktiko ilmastonmuutos polyamiinijohdokset polyamiinit

Julkaisut

55/55 kappaletta

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions
Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R.. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation
Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. Biomolecules
Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis
Khandazhinskaya, Anastasia; Eletskaya, Barbara; Fateev, Ilja; Kharitonova, Maria; Konstantinova, Irina; Barai, Vladimir; Azhayev, Alex; Hyvonen, Mervi T.; Keinanen, Tuomo A.; Kochetkov, Sergey; Seley-Radtke, Katherine; Khomutov, Alex; Matyugina, Elena. 2021. Organic and biomolecular chemistry
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li, Qian; Hagberg, Carolina E.; Silva Cascales, Helena; Lang, Shuai; Hyvönen, Mervi T.; Salehzadeh, Firoozeh; Chen, Ping; Alexandersson, Ida; Terezaki, Eleni; Harms, Matthew J.; Kutschke, Maria; Arifen, Nahida; Krämer, Niels; Aouadi, Myriam; Knibbe, Carole; Boucher, Jeremie; Thorell, Anders; Spalding, Kirsty L.. 2021. Nature medicine
Chemical activation of SAT1 corrects diet-induced metabolic syndrome
Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans et al. [incl. Keinänen, Tuomo]. 2020. Cell death and differentiation
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Biomolecules
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine
Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR. 2020. Russian journal of bioorganic chemistry
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Journal of medicinal chemistry
Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase
Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Mendeleev communications
Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration
Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Biochemical journal
Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators
Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Bioscience reports
Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism
Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV. 2017. Biochemical and biophysical research communications
Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo
Nissinen Tuomo, Näkki Simo, Laakso Hanne, Kuciauskas Dalius, Kaupinis Algirdas, Kettunen Mikko I, Liimatainen Timo, Hyvönen Mervi, Valius Mindaugas, Gröhn Olli, Lehto Vesa-Pekka. 2016. Acs applied materials and interfaces
Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer
Thomas TJ, Thomas Thresia, John Shali, Hsu Hui-Chen, Yang PingAr, Keinänen Tuomo A, Hyvönen Mervi T. 2016. Amino acids
Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation
Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Biochemical journal
Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport
Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A. 2015. Acs chemical biology
Enantioselective synthesis of (R)- and (S)-3-methylspermidines
Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR. 2015. Russian journal of bioorganic chemistry
Synthesis of biologically active analogues of spermine and spermidine
Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R.. 2015. Amino acids
Hydroxylamine derivatives for regulation of spermine and spermidine metabolism
Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. 2014. Biochemistry: moscow
Maintenance of white adipose tissue in man
Hyvönen Mervi T, Spalding Kirsty L. 2014. International journal of biochemistry and cell biology
Charge deficient analogues of the natural polyamines
Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R. 2013. Current pharmaceutical design
Selective regulation of polyamine metabolism with methylated polyamine analogues
Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R. 2013. Amino acids
Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A
Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Biochemical journal
A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells
Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ. 2012. Amino acids
Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells
Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V. 2012. Biochimie
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A
Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H. 2012. Amino acids
Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase
Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A. 2012. Drug metabolism and disposition
Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase
Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena. 2012. Amino acids
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with polyamine analogue bismethylspermine
Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Grigorenko N, Khomutov AR, Nordback I, Räty S, Pörsti I, Alhonen L, Sand J. 2011. Pharmacological reports
Complex N-Acetylation of Triethylentetramine
Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen. 2011. Drug metabolism and disposition
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults
Cerrada-Gimenez M, Pietilä Marko, Loimas Suvikki, Pirinen Eija , Hyvönen Mervi T, Keinänen Tuomo A, Jänne Juhani, Alhonen Leena. 2011. Transgenic research
Novel metabolically stable functionally active mimetic of spermidine
Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA. 2011. Russian journal of bioorganic chemistry
Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis
Jin Hai-Tao, Lämsä Teemu, Nordbak Panu H, Hyvönen Mervi T, Räty Sari, Nordback Isto, Herzig Karl-Heinz, Alhonen Leena, Sand Juhani. 2011. Pancreatology
The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism
Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov. 2011. Journal of medicinal chemistry
Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis
Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L. 2010. Pancreatology
DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage
Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ. 2010. Biomacromolecules
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Amino acids
Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity
Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P. 2010. Amino acids
Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues
Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Journal of medicinal chemistry
alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage
Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L. 2010. Amino acids
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues
Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA. 2009. Biochemical journal
Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism
Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. MOLEKULIARNAIA BIOLOGIIA [MOSKVA]
Transgenic animals modelling polyamine metabolism-related diseases
Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA. 2009. Essays in biochemistry
A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate
Jin H-T, Lämsä T, Hyvönen MT, Sand J, Räty S, Grigorenko N, Khomutov AR, Herzig K-H, Alhonen L, Nordback I. 2008. Surgery
Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis
Jin HT, Lämsa T, Merentie M, Hyvönen MT, Sand J, Räty S, Herzig K-H, Alhonen L, Nordback I. 2008. Pancreatology
Alpha-methylated polyamines as potential drugs and experimental tools in enzymology
Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. 2007. Mini-reviews in medicinal chemistry
Mechanisms of polyamine catabolism-induced acute pancreatitis
Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L. 2007. Biochemical society transactions
Regulation of Spermidine/Spermine N1-Acetyltransferase and its Involvement in Cellular Proliferation and Development of Acute Pancreatitis
Hyvönen MT. 2007. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis
Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. 2007. Journal of biological chemistry
Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality
Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. 2006. American journal of pathology
Genetic engineering of polyamine catabolism in transgenic mice and rats
Jänne J, Alhonen L, Pietilä M, Keinänen TA, Suppola S, Pirinen E, Hyvönen MT, Järvinen A, Laakso M. 2006. Humana Press
Genetic manipulation of polyamine catabolism in rodents
Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E. 2006. Journal of biochemistry
Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase
Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J. 2006. RNA
Animal disease models generated by genetic engineering of polyamine metabolism
Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A. 2005. Journal of cellular and molecular medicine
Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines
Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J. 2005. Journal of biological chemistry

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

Facebook Instagram YouTube LinkedIn Snapchat SoundCloud TikTok Vimeo

Saavutettavuusseloste
Evästeiden käyttö
Anna palautetta

Hallinnoi evästeiden suostumusta

Palvelu käyttää evästeitä sivuston optimointiin.

Toiminnalliset Toiminnalliset Aina aktiivinen

Tekninen tallennus tai pääsy on ehdottoman välttämätön oikeutettua tarkoitusta varten, joka mahdollistaa tietyn tilaajan tai käyttäjän nimenomaisesti pyytämän palvelun käytön, tai yksinomaan viestinnän välittämiseksi sähköisen viestintäverkon kautta.

Asetukset Asetukset

Tekninen tallennus tai pääsy on tarpeen laillisessa tarkoituksessa sellaisten asetusten tallentamiseen, joita tilaaja tai käyttäjä ei ole pyytänyt.

Tilastot Tilastot

Tekninen tallennus tai pääsy, jota käytetään yksinomaan tilastollisiin tarkoituksiin. Tekninen tallennus tai pääsy, jota käytetään yksinomaan anonyymeihin tilastollisiin tarkoituksiin. Ilman haastetta, Internet-palveluntarjoajasi vapaaehtoista suostumusta tai kolmannen osapuolen lisätietueita pelkästään tähän tarkoitukseen tallennettuja tai haettuja tietoja ei yleensä voida käyttää tunnistamaan sinua.

Markkinointi Markkinointi

Teknistä tallennustilaa tai pääsyä tarvitaan käyttäjäprofiilien luomiseen mainosten lähettämistä varten tai käyttäjän seuraamiseksi verkkosivustolla tai useilla verkkosivustoilla vastaavia markkinointitarkoituksia varten.

Näytä asetukset

{title} {title} {title}

Tarkenna hakuasi

Mervi Hyvönen

Tutkimusryhmät

Avainsanat

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Chemical activation of SAT1 corrects diet-induced metabolic syndrome

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase

Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism

Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo

Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

Enantioselective synthesis of (R)- and (S)-3-methylspermidines

Synthesis of biologically active analogues of spermine and spermidine

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism

Maintenance of white adipose tissue in man

Charge deficient analogues of the natural polyamines

Selective regulation of polyamine metabolism with methylated polyamine analogues

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase

Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with polyamine analogue bismethylspermine

Complex N-Acetylation of Triethylentetramine

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults

Novel metabolically stable functionally active mimetic of spermidine

Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis

The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism

Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases

Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity

Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism

Transgenic animals modelling polyamine metabolism-related diseases

A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate

Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology

Mechanisms of polyamine catabolism-induced acute pancreatitis

Regulation of Spermidine/Spermine N1-Acetyltransferase and its Involvement in Cellular Proliferation and Development of Acute Pancreatitis

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis

Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality

Genetic engineering of polyamine catabolism in transgenic mice and rats

Genetic manipulation of polyamine catabolism in rodents

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase

Animal disease models generated by genetic engineering of polyamine metabolism

Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines