Pirkko Pussinen - UEFConnect

Tarkenna hakuasi

visit profile´s X (Twitter) page

Tiedot Julkaisut

Translationaalisen hammaslääketieteen tarkoitus on tehdä monitieteellistä tutkimusta, joka tukee tutkitun tiedon tuntemusta hammaslääkärin vastaanotolla potilastyössä. Vastaavasti translationaalinen hammaslääketieteen tutkimus pyrkii tunnistamaan kliinisen työn tutkimustarpeita, joita pyritään selvittämään laboratoriotutkimuksilla. Alan pyrkimyksenä on vahvistaa ja edistää perustutkijoiden ja kliinisten tutkijoiden välistä yhteistyötä. Tutkimusryhmän työn tarkoitus on selventää, kuinka suun krooniset tulehdussairaudet yhdistyvät kroonisiin kansansairauksiin, kuten sydän- ja verisuonisairauksiin ja kardiometabolisiin häiriöihin. Toisaalta translationaalinen hammaslääketiede pyrkii lisäämään tietoisuutta suun terveyden tärkeydestä kokonaishyvinvoinnille sekä lääkäreiden että yleisön keskuudessa.

- Severity and progression rate of periodontitis are associated with an increased risk of hypertension of patients attending a university clinic.
  Yildirim BG, Aksit C, Mutlu M, Ainola M, Eklund KK, Leskelä J, Pussinen P, Beklen A. BMC Oral Health. 2022 Dec 22;22(1):627.
- Volatile composition of the morning breath.
  Roslund K, Lehto M, Pussinen P, Metsälä M. J Breath Res. 2022 Sep 19;16(4).
- Blood and saliva SARS-CoV-2 antibody levels in self-collected dried spot samples.
  Lahdentausta L, Kivimäki A, Oksanen L, Tallgren M, Oksanen S, Sanmark E, Salminen A, Geneid A, Sairanen M, Paju S, Saksela K, Pussinen P, Pietiäinen M. Med Microbiol Immunol. 2022 Aug;211(4):173-183.
- Common complement factor H polymorphisms are linked with periodontitis in elderly patients.
  Salminen A, Pietiäinen M, Paju S, Sorsa T, Mäntylä P, Buhlin K, Sinisalo J, Pussinen PJ. J Periodontol. 2022 Nov;93(11):1626-1634.
- Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia.
  Pussinen PJ, Kopra E, Pietiäinen M, Lehto M, Zaric S, Paju S, Salminen A. Periodontol 2000. 2022 Jun;89(1):19-40.
- Systemic Antibiotics Influence Periodontal Parameters and Oral Microbiota, But Not Serological Markers.
  Kopra E, Lahdentausta L, Pietiäinen M, Buhlin K, Mäntylä P, Hörkkö S, Persson R, Paju S, Sinisalo J, Salminen A, Pussinen PJ. Front Cell Infect Microbiol. 2021 Dec 24;11:774665.
- Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.
  Leskelä J, Toppila I, Härma MA, Palviainen T, Salminen A, Sandholm N, Pietiäinen M, Kopra E, Pais de Barros JP; FinnGen; Lassenius MI, Kumar A, Harjutsalo V, Roslund K, Forsblom C, Loukola A, Havulinna AS, Lagrost L, Salomaa V, Groop PH, Perola M, Kaprio J, Lehto M, Pussinen PJ. J Am Heart Assoc. 2021 Nov 2;10(21):e022482.
- Subgingival microbiota in a population with and without cognitive dysfunction.
  Holmer J, Aho V, Eriksdotter M, Paulin L, Pietiäinen M, Auvinen P, Schultzberg M, Pussinen PJ, Buhlin K. J Oral Microbiol. 2021 Jan 15;13(1):1854552.
- Endotoxemia is associated with an adverse metabolic profile.
  Määttä AM, Salminen A, Pietiäinen M, Leskelä J, Palviainen T, Sattler W, Sinisalo J, Salomaa V, Kaprio J, Pussinen PJ. Innate Immun. 2021 Jan;27(1):3-14.
- Endotoxemia is associated with an adverse metabolic profile.
  Määttä AM, Salminen A, Pietiäinen M, Leskelä J, Palviainen T, Sattler W, Sinisalo J, Salomaa V, Kaprio J, Pussinen PJ. Innate Immun. 2021 Jan;27(1):3-14.
- Childhood Oral Infections Associate with Adulthood Metabolic Syndrome: A Longitudinal Cohort Study.
  Pussinen PJ, Paju S, Viikari J, Salminen A, Taittonen L, Laitinen T, Burgner D, Kähönen M, Lehtimäki T, Hutri-Kähönen N, Raitakari O, Juonala M. J Dent Res. 2020 Sep;99(10):1165-1173.
- Saliva and Serum Immune Responses in Apical Periodontitis.
  Pietiäinen M, Liljestrand JM, Akhi R, Buhlin K, Johansson A, Paju S, Salminen A, Mäntylä P, Sinisalo J, Tjäderhane L, Hörkkö S, Pussinen PJ. J Clin Med. 2019 Jun 21;8(6):889.
- Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood.
  Pussinen PJ, Paju S, Koponen J, Viikari JSA, Taittonen L, Laitinen T, Burgner DP, Kähönen M, Hutri-Kähönen N, Raitakari OT, Juonala M. JAMA Netw Open. 2019 Apr 5;2(4):e192523.

Avainsanat

biomarkkerit lipopolysakkaridi lipoproteiinit matala-asteinen tulehdus parodontologia Suun mikrobiomi sydän- ja verisuonisairaudet tulehdus vasta-aineet

Julkaisut

42/42 kappaletta

Tarkenna hakuasi

Pirkko J. Pussinen

Tärkeimmät julkaisut

Avainsanat

Denture-associated oral microbiome in dentate and edentulous older adults living in long-term care facilities

Microbial burden of periodontal diseases and its clinical application: The stage, grade, and furcation matter

Modulation of LPS-associated virulence activity for reduction of periodontal inflammatory burden

Obstructive sleep apnea and periodontitis: a systematic review with considerations on CPAP therapy

Oral microbiota and periodontal health: the oral–brain axis in cognitive ageing

Periodontitis and Endotoxemia: Clinical and Microbiological Insights

Serum TIMP-1 concentrations are associated with cancer incidence and cancer-related mortality in a population-based cohort

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

Systemic Lipidomics Identifies Altered Ceramide-Phospholipid Balance Associated With Periodontitis Severity: A Cross-Sectional Study With 12-Year Follow-Up

Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults

Changes in Salivary Matrix Metalloproteinase-8 Concentrations Are Not Associated with Oral Health during Early Adolescence

Elevated levels of salivary interleukin-34 in patients suffering from Alzheimer’s disease

GWAS of Serum Antibodies to Microbial Biomarker Species of Periodontitis

Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers

Genome-wide association study of pulpal and apical diseases

Metabolic Profiling of Individuals with Missing Teeth and Tooth Loss

Metagenomic analysis of the denture-associated oral microbiome in patients with denture stomatitis

Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity

Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale

Successful endodontic treatment improves glucose and lipid metabolism: a longitudinal metabolomic study

The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome

The association of periodontal inflammation and inflammatory markers with cognitive dysfunction: A case–control study

Tooth-surface plaque microbiome and different levels of oral disease burden among dentate older adults living in long-term care

Burden of oral diseases predicts development of excess weight in early adolescence: a 2-year longitudinal study

Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke

Periodontitis, Dental Procedures, and Young-Onset Cryptogenic Stroke

Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status

Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study

Suunterveys heijastuu veren aineenvaihduntatuotteiden tasapainoon

Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross-sectional analysis

FinnGen provides genetic insights from a well-phenotyped isolated population

Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1)

Parodontiitin vaihe ja riskiluokka yhteydessä verenpainetautiriskiin

Salivary IgA and IgG Antibody Responses against Periodontitis-Associated Bacteria in Crohn’s Disease

Subgingival microbiome at different levels of cognition

Systemic Metabolic Signatures of Oral Diseases

Working conditions during the COVID-19 pandemic in primary and tertiary healthcare: a comparative cross-sectional study

Antibiotic treatment and supplemental hemin availability affect the volatile organic compounds produced by P. gingivalis in vitro

Blood and saliva SARS-CoV-2 antibody levels in self-collected dried spot samples

Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

Severity and progression rate of periodontitis are associated with an increased risk of hypertension of patients attending a university clinic

Volatile composition of the morning breath