Sanna-Kaisa Herukka
Tutkimusjohtaja
Kliinisen lääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta
Tutkimusryhmät
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Aivobiomarkkeritutkimukset 08.06.2004 - -
Aivotutkimusyksikkö -
Clinical Alzheimer Research 01.01.2022 - -
NPH and Early AD 01.01.2010 -
Projektit
Julkaisut
139/139 kappaletta-
Computerized decision support to optimally funnel patients through the diagnostic pathway
van Gils, Aniek M.; Tolonen, Antti; van Harten, Argonde C.; Koikkalainen, Juha; Barkhof, Frederik; Herukka, Sanna‐Kaisa; Hasselbalch, Steen G.; Mecocci, Patrizia; Remes, Anne; Soininen, Hilkka; Lemstra, Afina Willemina; Teunissen, Charlotte; Lötjönen, Jyrki; van der Flier, Wiesje M.; Meester, Hanneke F.M. Rhodius-Meester. 2025. Alzheimer's & dementia poster -
Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia
van Gils, Aniek M.; Tolonen, Antti; van Harten, Argonde C.; Vigneswaran, Sinthujah; Barkhof, Frederik; Visser, Leonie N. C.; Koikkalainen, Juha; Herukka, Sanna-Kaisa; Hasselbalch, Steen Gregers; Mecocci, Patrizia; Remes, Anne M.; Soininen, Hilkka; Lemstra, Afina W.; Teunissen, Charlotte E.; Jönsson, Linus; Lötjönen, Jyrki; van der Flier, Wiesje M.; Rhodius-Meester, Hanneke FM. 2024. Alzheimer's research and therapy. 16: . 256 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Exploring the Association Between Visual Field Testing and CERAD Neuropsychological Battery in Idiopathic Normal Pressure Hydrocephalus Patients
Kemiläinen, Benjam; Tiainen, Sonja; Rauramaa, Tuomas; Luikku, Antti J; Herukka, Sanna-Kaisa; Koivisto, Anne; Hiltunen, Mikko; Verdooner, Steven; Johnson, Ken; Chambers, Mieko; Kaarniranta, Kai; Leinonen, Ville. 2024. Journal of Alzheimer's disease. 100: 247-260 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease
Vuoksimaa, Eero; Saari, Toni T; Aaltonen, Aino; Aaltonen, Sari; Herukka, Sanna-Kaisa; Iso-Markku, Paula; Kokkola, Tarja; Kyttälä, Aija; Kärkkäinen, Sari; Liedes, Hilkka; Ollikainen, Miina; Palviainen, Teemu; Ruotsalainen, Ilona; Toivola, Auli; Urjansson, Mia; Vasankari, Tommi; Vähä-Ypyä, Henri; Forsberg, Markus M; Hiltunen, Mikko; Jalanko, Anu; Kälviäinen, Reetta; Kuopio, Teijo; Lähteenmäki, Jaakko; Nyberg, Pia; Männikkö, Minna; Serpi, Raisa; Siltanen, Sanna; Palotie, Aarno; Kaprio, Jaakko; Runz. 2024. BMJ open. 14: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The association of menopausal hormone levels with progression-related biomarkers in multiple sclerosis
Juutinen, Laura; Ahinko, Katja; Hagman, Sanna; Basnyat, Pabitra; Jääskeläinen, Olli; Herukka, Sanna-Kaisa; Sumelahti, Marja-Liisa. 2024. Multiple sclerosis and related disorders. 85: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A FinnGen pilot clinical recall study for Alzheimer’s disease
Julkunen, Valtteri; Schwarz, Claudia; Kalapudas, Juho; Hallikainen, Merja; Piironen, Aino-Kaisa; Mannermaa, Arto; Kujala, Hanna; Laitinen, Timo; Kosma, Veli-Matti; Paajanen, Teemu I.; Kälviäinen, Reetta; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kärkkäinen, Sari; Kokkola, Tarja; Urjansson, Mia; FinnGen; Perola, Markus; Palotie, Aarno; Vuoksimaa, Eero; Runz, Heiko. 2023. Scientific reports. 13: . 12641 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Cerebrospinal Fluid Diagnostics of Alzheimer's Disease in Patients with Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Lukkarinen, Heikki; Kokkola, Tarja; Koivisto, Anne M.; Kokki, Merja; Musialowicz, Tadeusz; Hiltunen, Mikko; Zetterberg, Henrik; Leinonen, Ville; Herukka, Sanna Kaisa; Rauramaa, Tuomas. 2023. Journal of Alzheimer's disease. 94: 727-736 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Vanninen, Aleksi; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Kokkola, Tarja; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Blennow, Kaj; Zetterberg, Henrik; Leinonen, Ville. 2023. Journal of Alzheimer's disease. 91: 305-319 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Cortico-spinal tDCS in amyotrophic lateral sclerosis: A randomized, double-blind, sham-controlled trial followed by an open-label phase
Benussi, Alberto; Cantoni, Valentina; Grassi, Mario; Libri, Ilenia; Cotelli, Maria Sofia; Tarantino, Barbara; Datta, Abhishek; Thomas, Chris; Huber, Nadine; Kärkkäinen, Sari; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Filosto, Massimiliano; Padovani, Alessandro; Borroni, Barbara. 2023. Brain stimulation. 16: 1666-1676 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Early Alzheimer's disease pathology in human cortex involves transient cell states
Gazestani, Vahid; Kamath, Tushar; Nadaf, Naeem M; Dougalis, Antonios; Burris, SJ; Rooney, Brendan; Junkkari, Antti; Vanderburg, Charles; Pelkonen, Anssi; Gomez-Budia, Mireia; Välimäki, Nelli Noora; Rauramaa, Tuomas; Therrien, Martine; Koivisto, Anne M; Tegtmeyer, Matthew; Herukka, Sanna Kaisa; Abdulraouf, Abdulraouf; Marsh, Samuel E; Hiltunen, Mikko; Nehme, Ralda; Malm, Tarja; Stevens, Beth; Leinonen, Ville; Macosko, Evan Z. 2023. Cell. 186: 4438-4453.e23 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Neurofilament light level correlates with brain atrophy, and cognitive and motor performance
Kartau, Marge; Melkas, Susanna; Kartau, Joonas; Arola, Anne; Laakso, Hanna; Pitkänen, Johanna; Lempiäinen, Juha; Koikkalainen, Juha; Lötjönen, Jyrki; Korvenoja, Antti; Ahlström, Matti; Herukka, Sanna Kaisa; Erkinjuntti, Timo; Jokinen, Hanna. 2023. Frontiers in aging neuroscience. 14: . 939155 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Rare PMP22 variants in mild to severe neuropathy uncorrelated to plasma GDF15 or neurofilament light
Palu, Edouard; Järvilehto, Julius; Pennonen, Jana; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Isohanni, Pirjo; Tyynismaa, Henna; Auranen, Mari; Ylikallio, Emil. 2023. Neurogenetics. 24: 291-301 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals
Heikkinen, Sami; Huber, Nadine; Katisko, Kasper; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Leinonen, Ville; Korhonen, Ville E; Herukka, Sanna-Kaisa; Remes, Anne M; Borroni, Barbara; Alberici, Antonella; Libri, Ilenia; Solje, Eino; Haapasalo, Annakaisa. 2023. Journal of Alzheimer's disease. 93: 395-401 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The Incidence and Outcomes of Head Injuries in People with and without Parkinson's Disease
Ilmaniemi, Sarianna; Tolppanen, Anna‐Maija; Herukka, Sanna‐Kaisa; Hartikainen, Päivi; Hartikainen, Sirpa. 2023. European journal of neurology. 30: 1648-1657 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients
Lukkarinen, Heikki; Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M.; Herukka, Sanna-Kaisa; Hiltunen, Mikko; Rauramaa, Tuomas; Nägga, Katarina; Leinonen, Ville; Tullberg, Mats. 2022. Fluids and barriers of the cns. 19: . 11 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Circulating neurofilament is linked with morbid obesity, renal function, and brain density
Rebelos, Eleni; Rissanen, Eero; Bucci, Marco; Jääskeläinen, Olli; Honka, Miikka-Juhani; Nummenmaa, Lauri; Moriconi, Diego; Laurila, Sanna; Salminen, Paulina; Herukka, Sanna-Kaisa; Singhal, Tarun; Nuutila, Pirjo. 2022. Scientific reports. 12: . 7841 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Jansen, Iris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar; Dalmasso, Maria Carolina; Grenier-Boley, Benjamin; Zettergren, Anna; Mishra, Aniket; Ali, Muhammad; Andrade, Victor; Bellenguez, Céline; Kleineidam, Luca; Küçükali, Fahri; Sung, Yun Ju; Tesí, Niccolo; Vromen, Ellen M.; Wightman, Douglas P.; Alcolea, Daniel; Alegret, Montserrat; Alvarez, Ignacio; Amouyel, Philippe; Athanasiu, Lavinia; Bahrami, Shahram; Bailly, Henri; Belbin, Olivia; Bergh, Sverre; Bertram, Lars; Biesse. 2022. Acta neuropathologica. 144: 821-842 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
Giannini, Giulia; Baiardi, Simone; Dellavalle, Sofia; Zenesini, Corrado; Cevoli, Sabina; Danner, Nils; Jyrkkänen, Henna-Kaisa; Rossi, Marcello; Polischi, Barbara; Quadalti, Corinne; Stefanini, Camilla; Cortelli, Pietro; Milletti, David; Herukka, Sanna-Kaisa; Palandri, Giorgio; Leinonen, Ville; Parchi, Piero. 2022. Fluids and barriers of the cns. 19: . 71 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Laadukasta palvelua ja tutkimusta Itä-Suomen yliopiston aivotutkimusyksikön Biomarkkerilaboratoriossa
Kokkola, Tarja; Kärkkäinen, Sari; Herukka, Sanna-Kaisa. 2022. Kliin lab. 39: 72-75 D1 Artikkeli ammattilehdessä -
Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons
Sainio, Markus T.; Rasila, Tiina; Molchanova, Svetlana M.; Järvilehto, Julius; Torregrosa-Muñumer, Rubén; Harjuhaahto, Sandra; Pennonen, Jana; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Zetterberg, Henrik; Taira, Tomi; Palmio, Johanna; Ylikallio, Emil; Tyynismaa, Henna. 2022. Frontiers in cell and developmental biology. 9: . 820105 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI
Heiskanen, Mette; Jääskeläinen, Olli; Manninen, Eppu; Das Gupta, Shalini; Andrade, Pedro; Ciszek, Robert; Gröhn, Olli; Herukka, Sanna-Kaisa; Puhakka, Noora; Pitkänen, Asla. 2022. International journal of molecular sciences. 23: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
Jansen, Willemijn J.; Janssen, Olin; Tijms, Betty M.; Vos, Stephanie J. B.; Ossenkoppele, Rik; Visser, Pieter Jelle; Aarsland, Dag; Alcolea, Daniel; Altomare, Daniele; von Arnim, Christine; Baiardi, Simone; Baldeiras, Ines; Barthel, Henryk; Bateman, Randall J.; Van Berckel, Bart; Binette, Alexa Pichet; Blennow, Kaj; Boada, Merce; Boecker, Henning; Bottlaender, Michel; den Braber, Anouk; Brooks, David J.; Van Buchem, Mark A.; Camus, Vincent; Carill, Jose Manuel; Cerman, Jiri; Chen, Kewei; Chétela. 2022. JAMA neurology. 79: 228-243 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Katisko, Kasper; Huber, Nadine; Kokkola, Tarja; Hartikainen, Päivi; Krüger, Johanna; Heikkinen, Anna-Leena; Paananen, Veera; Leinonen, Ville; Korhonen, Ville E.; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Cantoni, Valentina; Gadola, Yasmine; Archetti, Silvana; Remes, Anne M.; Haapasalo, Annakaisa; Borroni, Barbara; Solje, Eino. 2022. Alzheimer's research and therapy. 14: . 151 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism
Kenvin, Sebastian; Torregrosa-Muñumer, Ruben; Reidelbach, Marco; Pennonen, Jana; Turkia, Jeremi J; Rannila, Erika; Kvist, Jouni; Sainio, Markus T; Huber, Nadine; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Auranen, Mari; Trokovic, Ras; Sharma, Vivek; Ylikallio, Emil; Tyynismaa, Henna. 2022. Human molecular genetics. 31: 958-974 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Use of gliptins reduces levels of SDF-1/CXCL12 in bullous pemphigoid and type 2 diabetes, but does not increase autoantibodies against BP180 in diabetic patients
Nätynki, Antti; Leisti, Päivi; Tuusa, Jussi; Varpuluoma, Outi; Huilaja, Laura; Izumi, Kentaro; Herukka, Sanna Kaisa; Ukkola, Olavi; Junttila, Juhani; Kokkonen, Nina; Tasanen, Kaisa. 2022. Frontiers in immunology. 13: . 942131 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions
Kaipainen, Aku L; Pitkänen, Johanna; Haapalinna, Fanni; Jääskeläinen, Olli; Jokinen, Hanna; Melkas, Susanna; Erkinjuntti, Timo; Vanninen, Ritva; Koivisto, Anne M; Lötjönen, Jyrki; Koikkalainen, Juha; Herukka, Sanna-Kaisa; Julkunen, Valtteri. 2021. Neuroradiology -
Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Vanninen, Aleksi; Nakajima, Madoka; Miyajima, Masakazu; Rauramaa, Tuomas; Kokki, Merja; Musialowicz, Tadeusz; Mäkinen, Petra M; Herukka, Sanna-Kaisa; Koivisto, Anne M; Jääskeläinen, Juha E; Hiltunen, Mikko; Leinonen, Ville. 2021. Journal of clinical medicine -
GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance
Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. 2021. Journal of neurology neurosurgery and psychiatry. 92: 1305-1312 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis
Niiranen, Marja; Kontkanen, Aleksi; Jääskeläinen, Olli; Tertsunen, Hanna-Mari; Selander, Tuomas; Hartikainen, Päivi; Huber, Nadine; Solje, Eino; Haapasalo, Annakaisa; Kokkola, Tarja; Lohioja, Tarja; Herukka, Sanna-Kaisa; Simula, Sakari; Remes, Anne M.. 2021. Multiple sclerosis and related disorders -
Serum Neurofilament Light in Patients with Frontotemporal Dementia Caused by CHMP2B Mutation
Toft, Anders; Roos, Peter; Jääskeläinen, Olli; Musaeus, Christian Sandoe; Henriksen, Emil Elbaek; Johannsen, Peter; Nielsen, Troels Tolstrup; Herukka, Sanna-Kaisa; Hviid Simonsen, Anja; Nielsen, Jorgen Erik. 2021. Dementia and geriatric cognitive disorders -
Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus
Lukkarinen, Heikki; Tesseur, Ina; Pemberton, Darrel; Van Der Ark, Peter; Timmers, Maarten; Slemmon, Randy; Janssens, Luc; Streffer, Johannes; Van Nueten, Luc; Bottelbergs, Astrid; Rauramaa, Tuomas; Koivisto, Anne M.; Herukka, Sanna-Kaisa; Korhonen, Ville E.; Junkkari, Antti; Hiltunen, Mikko; Engelborghs, Sebastiaan; Blennowk, Kaj; Zetterbergk, Henrik; Kolb, Hartmuth C.; Leinonen, Ville. 2021. Journal of Alzheimer's disease -
Cerebrospinal Fluid and MRI Biomarkers in Neurodegenerative Diseases: A Retrospective Memory Clinic-Based Study
Kaipainen, Aku; Jääskeläinen, Olli; Liu, Yawu; Haapalinna, Fanni; Nykänen, Niko; Vanninen, Ritva; Koivisto, Anne M; Julkunen, Valtteri; Remes, Anne M; Herukka, Sanna-Kaisa. 2020. Journal of Alzheimer's disease -
Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort
Muurling, Marijn; Rhodius-Meester, Hanneke; Pärkkä, Juha; van Gils, Mark; Frederiksen, Kristian S; Bruun, Marie; Hasselbalch, Steen G; Soininen, Hilkka; Herukka, Sanna-Kaisa; Hallikainen, Merja; Teunissen, Charlotte E; Visser, Pieter; Scheltens, Philip; van der Flier, Wiesje M; Mattila, Jussi; Lötjönen, Jyrki; de Boer, Casper. 2020. Journal of Alzheimer's disease -
Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.
Jääskeläinen, O; Hall, A; Tiainen, M; van Gils, M; Lötjönen, J; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Hallikainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, P; Soininen, H; Herukka, S-K. 2020. Journal of Alzheimer's disease -
PTPR type Q in cerebrospinal fluid reflects ependymal cells dysfunction and is a potential biomarker for adult chronic hydrocephalus
Nakajima, Madoka; Rauramaa, Tuomas; Mäkinen, Petra M; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kokki, Merja; Musialowicz, Tadeusz; Jyrkkänen, Henna-Kaisa; Danner, Nils; Junkkari, Antti; Koivisto, Anne M; Jääskeläinen, Juha E; Miyajima, Masakazu; Ogino, Ikuko; Furuta, Akiko; Akiba, Chihiro; Kawamura, Kaito; Kamohara, Chihiro; Sugano, Hidenori; Tange, Yuichi; et al. [incl. Leinonen, Ville]. 2020. European journal of neurology -
Parkinsonin taudin lääkkeiden erityiskorvausoikeuden saajien määrän muutos vuosina 1996-2015
Anttila, Margareta; Hartikainen, Sirpa; Herukka, Sanna-Kaisa; Kaasinen, Valtteri; Tolppanen, Anna-Maija. 2020. Lääkärilehti -
Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy
Rhodius-Meester, HFM; van Maurik, IS; Koikkalainen, J; Tolonen, A; Frederiksen, KS; Hasselbalch, SG; Soininen, H; Herukka, SK; Remes, AM; Teunissen, CE; Barkhof, F; Pijnenburg, YAL; Scheltens, P; Lötjönen, J; van der Flier, WM. 2020. PLoS ONE -
Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis
Cajanus, Antti; Katisko, Kasper; Kontkanen, Aleksi; Jääskeläinen, Olli; Hartikainen, Päivi; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Vanninen, Ritva; Solje, Eino; Hall, Anette; Remes, Anne. 2020. Annals of clinical and translational neurology -
Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events
Onatsu, Juha; Vanninen, Ritva; Jäkälä, Pekka; Mustonen, Pirjo; Pulkki, Kari; Korhonen, Miika; Hedman, Marja; Höglund, Kina; Blennow, Kaj; Zetterberg, Henrik; Herukka, Sanna-Kaisa; Taina, Mikko. 2020. In vivo -
Vitamin D supplementation and serum neurofilament light chain in interferon-beta-1b-treated MS patients
Hänninen, Katariina; Jääskeläinen, Olli; Herukka, Sanna-Kaisa; Soilu-Hänninen, Merja. 2020. Brain and behavior -
White Matter Hyperintensities are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers
van Waalwijk van Doorn, Linda J C; Ghafoorian, Mohsen; van Leijsen, Esther M C; Claassen, Jurgen A H R; Arighi, Andrea; Bozzali, Marco; Cannas, Jorge; Cavedo, Enrica; Eusebi, Paolo; Farotti, Lucia; Fenoglio, Chiara; Fortea, Juan; Frisoni, Giovanni B; Galimberti, Daniela; Greco, Viviana; Herukka, Sanna-Kaisa; Liu, Yawu; Lleó, Alberto; de Mendonça, Alexandre; Nobili, Flavio M; et al. [incl. Pikkarainen, Maria; Soininen, Hilkka]. 2020. Journal of Alzheimer's disease -
cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders
Rhodius-Meester, HFM; Paajanen, T; Koikkalainen, J; Mahdiani, S; Bruun, M; Baroni, M; Lemstra, AW; Scheltens, P; Herukka, SK; Pikkarainen, M; Hall, A; Hänninen, T; Ngandu, T; Kivipelto, M; van Gils, M; Hasselbalch, SG; Mecocci, P; Remes, A; Soininen, H; van der Flier, WM; Lötjönen, J. 2020. Alzheimer's & dementia : diagnosis, assessment & disease monitoring -
BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer's Disease than in Bullous Pemphigoid
Tuusa, Jussi; Lindgren, Outi; Tertsunen, Hanna-Mari; Nishie, Wataru; Kokkonen, Nina; Huilaja, Laura; Izumi, Kentaro; Herukka, Sanna-Kaisa; Miettunen, Jouko; Shimizu, Hiroshi; Remes, Anne M; Tasanen, Kaisa. 2019. Journal of investigative dermatology -
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study
van Maurik, IS; Vos, SJ; Bos, I; Bouwman, FH; Teunissen, CE; Scheltens, P; Barkhof, F; Frolich, L; Kornhuber; J; Wiltfang, J; Maier, W; Peters, O; Rüther, E; Nobili, F; Frisoni, GB; Spiru, L; Freund-Levi, Y; Wallin, AK; Hampel, H; Soininen, H; Tsolaki, M; et al. (incl. Herukka, SK). 2019. The Lancet Neurology -
CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics
Jeppsson, Anna; Wikkelsö, Carsten; Blennow, Kaj; Zetterberg, Henrik; Constantinescu, Radu; Remes, Anne M; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Nagga, Katarina; Leinonen, Ville; Tullberg, Mats. 2019. Journal of neurology neurosurgery and psychiatry -
Impact of a clinical decision support tool on dementia diagnostics in memory clinics: The PredictND validation study
Bruun, M; Frederiksen, KS; Rhodius-Meester, HFM; Baroni, M; Gjerum, L; Koikkalainen, J; Urhema, T; Tolonen, A; van Gils, M; Tong, T; Rueckert, D; Dyremos, N; Bo Andersen, B; Simonsen, AH; Lemstra, A; Hallikainen, M; Kurl, S; Herukka, SK; Remes, AM; Waldemar, G; et al. (incl. Soininen, Hilkka). 2019. Current alzheimer research -
Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study
Bruun, M; Frederiksen, KS; Rhodius-Meester, HFM; Baroni, M; Gjerum, L; Koikkalainen, J; Urhemaa, T; Tolonen, A; van Gils, M; Rueckert, D; Dyremose, N; Andersen, BB; Lemstra, AW; Hallikainen, M; Kurl, S; Herukka, SK; Remes, AM; Waldemar, G; Soininen, H; Mecocci, P; et al. 2019. Alzheimer's research and therapy -
Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients
Jääskeläinen, O; Solje, E; Hall, A; Katisko, K; Korhonen, V; Tiainen, M; Kangas, AJ; Helisalmi, S; Pikkarainen, M; Koivisto, A; Hartikainen, P; Hiltunen, M; Ala-Korpela, M; Soininen, H; Soininen, P; Haapasalo, A; Remes, AM; Herukka, SK. 2019. Journal of Alzheimer's disease -
Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion
Katisko, K; Solje, E; Korhonen, P; Jääskeläinen, O; Loppi, S; Hartikainen, P; Koivisto, AM; Kontkanen, A; Korhonen, VE; Helisalmi, S; Malm, T; Herukka, SK; Remes, AM; Haapasalo, A. 2019. Journal of neurology -
Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus
Luikku, AJ; Hall, A; Nerg, O; Koivisto, AM; Hiltunen, M; Helisalmi, S; Herukka, SK; Junkkari, A; Sutela, A; Kojoukhova, M; Korhonen, V; Mattila, J; Lötjönen, J; Rummukainen, J; Alafuzoff, I; Jääskeläinen, JE; Remes, AM; Solomon, A; Kivipelto, M; Soininen, H; et al. [Incl. Rauramaa, T; Leinonen, V]. 2019. Journal of Alzheimer's disease -
Serum Neurofilament Light Chain Concentration Correlates with Infarct Volume but Not Prognosis in Acute Ischemic Stroke
Onatsu, Juha; Vanninen, Ritva; Jäkälä, Pekka; Mustonen, Pirjo; Pulkki, Kari; Korhonen, Miika; Hedman, Marja; Zetterberg, Henrik; Blennow, Kaj; Höglund, Kina; Herukka, Sanna-Kaisa; Taina, Mikko. 2019. Journal of stroke and cerebrovascular diseases -
Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders
Katisko, K; Cajanus, A; Jääskeläinen, O; Kontkanen, A; Hartikainen, P; Korhonen, VE; Helisalmi, S; Haapasalo, A; Koivumaa-Honkanen, H; Herukka, SK; Remes, AM; Solje, E. 2019. Journal of neurology -
[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-ß Load in Subjects Examined for Normal Pressure Hydrocephalus
Rinne, JO; Suotunen, T; Rummukainen, J; Herukka, SK; Nerg, O; Koivisto, AM; Rauramaa, T; Någren, K; Hiltunen, M; Alafuzoff, I; Rinne, J; Jääskeläinen, JE; Soininen, H; Leinonen, V. 2019. Journal of Alzheimer's disease -
Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients
Leal, NS; Dentoni, G; Schreiner, B; Kämäräinen, OP; Partanen, N; Herukka, SK; Koivisto, AM; Hiltunen, M; Rauramaa, T; Leinonen, V; Ankarcrona, M. 2018. Acta neuropathologica communications -
Alzheimerin taudin varhainen tunnistaminen
Koivisto, Anne M; Paajanen, Teemu; Rinne, Juha; Hokkanen, Laura; Vanninen, Ritva; Herukka, Sanna-Kaisa; Lötjönen, Jyrki; Hallikainen, Merja. 2018. Duodecim -
Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aß species
Oliveira, F; Leuzy, A; Castelhano, J; Chiotis, K; Hasselbalch, SG; Rinne, J; Mendonça, A; Otto, M; Lleó, A; Santana, I; Johansson, J; Anderl-Straub, S; Arnim, C; Beer, A; Blesa, R; Fortea, J; Herukka, S-K; Portelius, E; Pannee, J; Zetterberg, H; et al.. 2018. Neuroimage : clinical -
Decreased plasma C-reactive protein levels in APOE E 4 allele carriers
Martiskainen, Henna; Takalo, Mari; Solomon, Alina; Stancáková, Alena; Marttinen, Mikael; Natunen, Teemu; Haapasalo, Annakaisa; Herukka, Sanna-Kaisa; Kuusisto, Johanna; Soininen, Hilkka; Kivipelto, Miia; Laakso, Markku; Hiltunen, Mikko. 2018. Annals of clinical and translational neurology -
Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration
Katisko, Kasper; Haapasalo, Annakaisa; Koivisto, Anne; Kruger, Johanna; Hartikainen, Päivi; Korhonen, Ville; Helisalmi, Seppo; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino. 2018. Journal of Alzheimer's disease -
Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers
Katisko, K; Solje, E; Koivisto, AM; Krüger, J; Kinnunen, T; Hartikainen, P; Helisalmi, S; Korhonen, V; Herukka, S-K; Haapasalo, A; Remes, AM. 2018. Journal of neuroimmunology -
Prevalence of the apolipoprotein E epsilon4 allele in amyloid ß positive subjects across the spectrum of Alzheimer's disease
Mattsson, N; Groot, C; Jansen, WJ; Landau, S; Villemagne, V; Engelborghs, S; Mintun, M; Lleo, A; Molinuevo, JL; Jagust, W; Frisoni, GB; Ivanoiu, A; Chételat, G; Resende de Oliveira, C; Rodrigue, KM; Kornhuber, J; Wallin, A; Klimkowicz-Mrowiec, A; Kandimella, R; Popp, J et al [Incl Herukka, Kaisa]. 2018. Alzheimer's & dementia -
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers
de Matos, MR; Ferreira, C; Herukka, SK; Soininen, H; Janeiro, A; Santana, I; Baldeiras, I; Almeida, MR; Lleó, A; Dols-Icardo, O; Alcolea, D; Benussi, L; Binetti, G; Paterlini, A; Ghidoni, R; Nacmias, B; Meulenbroek, O; van Waalwijk van Doorn, LJC; Kuiperij, HB; Hausner, L; et al. 2018. Journal of Alzheimer's disease -
S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-ß Plaques and Tau in Brain Biopsies
Leinonen, V; Rauramaa, T; Johansson, J; Bottelbergs, A; Tesseur, I; van der Ark, P; Pemberton, D; Koivisto, AM; Jääskeläinen, JE; Hiltunen, M; Herukka, SK; Blennow, K; Zetterberg, H; Jokinen, P; Rokka, J; Helin, S; Haaparanta-Solin, M; Solin, O; Okamura, N; Kolb, HC; et al.. 2018. Journal of Alzheimer's disease -
Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subject
Haapalinna, F; Kokki, M; Jääskeläinen, O; Hallikainen, M; Helisalmi, S; Koivisto, A; Kokki, H; Paajanen, T; Penttinen, J; Pikkarainen, M; Rautiainen, M; Soininen, H; Solje, E; Remes, AM; Herukka, SK. 2018. Journal of Alzheimer's disease -
The association between frontotemporal lobar degeneration and bullous pemphigoid
Katisko, Kasper; Kokkonen, Nina; Krüger, Johanna; Hartikainen, Päivi; Koivisto, Anne; Helisalmi, Seppo; Korhonen, Ville; Kokki, Merja; Tuusa, Jussi; Herukka, Sanna-Kaisa; Solje, Eino; Haapasalo, Annakaisa; Tasanen, Kaisa; Remes, Anne. 2018. Journal of Alzheimer's disease. 66: 743-750 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation
Teunissen, Charlotte E; Otto, Markus; Engelborghs, Sebastiaan; Herukka, Sanna-Kaisa; Lehmann, Sylvain; Lewczuk, Piotr; Lleó, Alberto; Perret-Liaudet, Armand; Tumani, Hayrettin; Turner, Martin R; Verbeek, Marcel M; Wiltfang, Jens; Zetterberg, Henrik; Parnetti, Lucilla; Blennow, Kaj. 2018. Alzheimer's research and therapy -
Association of Cerebral Amyloid-ß Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J et al.. 2017. JAMA psychiatry -
Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers
Martiskainen H, Herukka SK, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. 2017. Annals of neurology -
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
van Waalwijk van Doorn LC, Gispert JD, Kuiperij HB, Claassen, JAHR, Arighi A, Baldeiras I, Blennow K, Bozzali M, Castelo-Branco M, Cavedo E, Emek-Savas D, Eren E, Eusebi P, Farotti L, Fenoglio C, Ormaechea JF, Freund-Levi Y, Frisoni G, Galimberti D, Genc S et al. 2017. Journal of Alzheimer's disease -
Preclinical effects of APOE [epsilon]4 on cerebrospinal fluid Aß42 concentrations
Lautner R, Insel PS, Skillbäck T, Olsson B, Landén M, Frisoni GB, Herukka SK, Hampel H, Wallin A, Minthon L, Hansson O, Blennow K, Mattsson N, Zetterberg H. 2017. Alzheimer's research and therapy -
Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia
Simonsen AH, Herukka SK, Andreasen N, Baldeiras I, Bjerke M, Blennow K, Engelborghs S, Frisoni GB, Gabryelewicz T, Galluzzi S, Handels R, Kramberger MG, Kulczynska A, Molinuevo JL, Mroczko B, Nordberg A, Oliveira CR, Otto M, Rinne JO, Rot U et al.. 2017. Alzheimer's & dementia -
Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment
Herukka SK, Simonsen AH, Andreasen N, Baldeiras I, Bjerke M, Blennow K, Engelborghs S, Frisoni GB, Gabryelewicz T, Galluzzi S, Handels R, Kramberger MG, Kulczynska A, Molinuevo JL, Mroczko B, Nordberg A, Oliveira CR, Otto M, Rinne JO, Rot U et al.. 2017. Alzheimer's & dementia -
The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Bos I, Vos SJ, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Engelborghs S, Niemantsverdriet E, De Roeck EE, Tsolaki M, Freund-Levi Y, Johannsen P, Vandenberghe R, Lleó A, Alcolea D, Frisoni GB, Galluzzi S, Nobili F et al., the Alzheimer's Disease Neuroimaging Initiative. 2017. Neurobiology of aging -
Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion
Junttila A, Kuvaja M, Hartikainen P, Siloaho M, Helisalmi S, Moilanen V, Kiviharju A, Jansson L, Tienari PJ, Remes AM, Herukka SK. 2016. Dementia and geriatric cognitive disorders -
Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics
Lelental N, Brandner S, Kofanova O, Blennow K, Zetterberg H, Andreasson U, Engelborghs S, Mroczko B, Gabryelewicz T, Teunissen C, Mollenhauer B, Parnetti L, Chiasserini D, Molinuevo JL, Perret-Liaudet A, Verbeek MM, Andreasen N, Brosseron F, Bahl JM, Herukka SK et al. 2016. Journal of Alzheimer's disease -
Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease
Kokkonen N, Herukka SK, Huilaja L, Kokki M, Koivisto AM, Hartikainen P, Remes AM, Tasanen K. 2016. Journal of investigative dermatology -
Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women
Haapalinna F, Paajanen T, Penttinen J, Kokki H, Kokki M, Koivisto AM, Hartikainen P, Solje E, Hänninen T, Remes AM, Herukka SK. 2016. Dementia and geriatric cognitive disorders extra -
Modified serpinA1 as risk marker for Parkinson's disease dementia: analysis of baseline data
Halbgebauer Steffen, Nagl Magdalena, Klafki Hans, Haußmann Ute, Steinacker Petra, Oeckl Patrick, Kassubek Jan, Pinkhardt Elmar, Ludolph Albert C, Soininen Hilkka, Herukka Sanna-Kaisa, Wiltfang Jens, Otto Markus. 2016. Scientific reports -
Multicenter immunoassay validation of cerebrospinal fluid neurofilament light: a biomarker for neurodegeneration
Miller AM, Rutkowska A, Bahl JM, Herukka SK, Koel-Simmelink MJ, Kruse N, Mollenhauer B, Siloaho M, Skinningsrud A, Zetterberg H, Teunissen CE, Lawlor BA. 2016. Bioanalysis -
Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS
Oeckl P, Jardel C, Salachas F, Lamari F, Andersen PM, Bowser R, de Carvalho M, Costa J, van Damme P, Gray E, Grosskreutz J, Hernández-Barral M, Herukka SK, Huss A, Jeromin A, Kirby J, Kuzma-Kozakiewicz M, Amador MDM, Mora JS, Morelli C et al. 2016. Amyotrophic lateral sclerosis & frontotemporal degeneration -
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus
Luikku Antti J, Hall Anette, Nerg Ossi, Koivisto Anne M, Hiltunen Mikko, Helisalmi Seppo, Herukka Sanna-Kaisa, Sutela Anna, Kojoukhova Maria, Mattila Jussi, Lötjönen Jyrki, Rummukainen Jaana, Alafuzoff Irina, Jääskeläinen Juha E, Remes Anne M, Soininen Hilkka, Leinonen Ville. 2016. Acta neurochirurgica -
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-ß in a multicentre European memory clinic study
Leuzy Antoine, Chiotis Konstantinos, Hasselbalch Steen G, Rinne Juha O, de Mendonça Alexandre, Otto Markus, Lleó Alberto, Castelo-Branco Miguel, Santana Isabel, Johansson Jarkko, Anderl-Straub Sarah, von Arnim Christine AF, Beer Ambros, Blesa Rafael, Fortea Juan, Herukka Sanna-Kaisa, Portelius Erik, Pannee Josef, Zetterberg Henrik, Blennow Kaj et al. 2016. Brain -
Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease
Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Husso M, Hänninen T, Vanninen R, Liu Y, Hallikainen M, Lötjönen J, Remes AM, Alafuzoff I, Soininen H, Hartikainen P. 2016. Dementia and geriatric cognitive disorders -
Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus
Herukka Sanna-Kaisa, Rummukainen Jaana, Ihalainen Jouni, von und zu Fraunberg Mikael, Koivisto Anne M, Nerg Ossi, Puli Lakshman K, Seppälä Toni T, Zetterberg Henrik, Pyykkö Okko T, Helisalmi Seppo, Tanila Heikki, Alafuzoff Irina, Hiltunen Mikko, Rinne Jaakko, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville. 2015. Journal of Alzheimer's disease -
CSF biomarkers for the differential diagnosis of Alzheimer's disease. A large-scale international multicenter study
Ewers Michael, Mattsson Niklas, Minthon Lennart, Molinuevo José L, Antonell Anna, Popp Julius, Jessen Frank, Herukka Sanna-Kaisa, Soininen Hilkka, Maetzler Walter, Leyhe Thomas, Bürger Katharina, Taniguchi Miyako, Urakami Katsuya, Lista Simone, Dubois Bruno, Blennow Kaj, Hampel Harald. 2015. Alzheimer's & dementia -
Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion
Kämäläinen A, Herukka S-K, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM. 2015. Dementia and geriatric cognitive disorders -
Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases
Lleó Alberto, Cavedo Enrica, Parnetti Lucilla, Vanderstichele Hugo, Herukka Sanna-Kaisa, Andreasen Niels, Ghidoni Roberta, Lewczuk Piotr, Jeromin Andreas, Winblad Bengt, Tsolaki Magda, Mroczko Barbara, Visser Pieter Jelle, Santana Isabel, Svenningsson Per, Blennow Kaj, Aarsland Dag, Molinuevo José Luis, Zetterberg Henrik, Mollenhauer Brit. 2015. Nature reviews neurology -
Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers
Leitão Maria João, Baldeiras Inês, Herukka Sanna-Kaisa, Pikkarainen Maria, Leinonen Ville, Simonsen Anja Hviid, Perret-Liaudet Armand, Fourier Anthony, Quadrio Isabelle, Veiga Pedro Mota, de Oliveira Catarina Resende. 2015. Frontiers in neurology -
Effects of Alzheimer's Disease-Associated Risk Loci on Cerebrospinal Fluid Biomarkers and Disease Progression: A Polygenic Risk Score Approach
Martiskainen Henna, Helisalmi Seppo, Viswanathan Jayashree, Kurki Mitja, Hall Anette, Herukka Sanna-Kaisa, Sarajärvi Timo, Natunen Teemu, Kurkinen Kaisa M.A., Huovinen Jaakko, Mäkinen Petra, Laitinen Marjo, Koivisto Anne M., Mattila Kari M., Lehtimäki Terho, Remes Anne M., Leinonen Ville, Haapasalo Annakaisa, Soininen Hilkka, Hiltunen Mikko. 2015. Journal of Alzheimer's disease -
Laboratoriotutkimukset
Herukka Sanna-Kaisa, Remes Anne. 2015. Kustannus Oy Duodecim -
Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage
Vos Stephanie JB, Verhey Frans, Frölich Lutz, Kornhuber Johannes, Wiltfang Jens, Maier Wolfgang, Peters Oliver, Rüther Eckart, Nobili Flavio, Morbelli Silvia, Frisoni Giovanni B, Drzezga Alexander, Didic Mira, van Berckel Bart NM, Simmons Andrew, Soininen Hilkka, Kloszewska Iwona, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Muscio Cristina, Herukka Sanna-Kaisa, Salmon Eric, Bastin Christine, Wallin Anders, Nordlund Arto, de Mendonça Alexandre, Silva Dina, Santana Isabel, Lemo. 2015. Brain -
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia A Meta-analysis
Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewic. 2015. JAMA : Journal of the American Medical Association -
The CERAD Neuropsychological Battery in Patients with Frontotemporal Lobar Degeneration
Haanpää RM, Suhonen N-M, Hartikainen P, Koivisto A M, Moilanen V, Herukka S-K, Hänninen T, Remes AM. 2015. Dementia and geriatric cognitive disorders -
The utility of alfa-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature
Simonsen Anja Hviid, Kuiperij Bea, Ali El-Agnaf Omar Mukhtar, Engelborghs Sebastian, Herukka Sanna-Kaisa, Parnetti Lucilla, Rektorova Irena, Vanmechelen Eugeen, Kapaki Elisabeth, Verbeek Marcel, Mollenhauer Britt. 2015. Biomarkers in medicine -
Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study
Zwan Marissa D, Rinne Juha O, Hasselbalch Steen G, Nordberg Agneta, Lleó Alberto, Herukka Sanna-Kaisa, Soininen Hilkka, Law Ian, Bahl Justyna MC, Carter Stephen F, Fortea Juan, Blesa Rafael, Teunissen Charlotte E, Bouwman Femke H, van Berckel Bart NM, Visser Pieter J. 2015. Neurology -
Altered cerebrospinal fluid levels of amyloid beeta and amyloid precursor-like protein 1 peptides in Down's Syndrome
Portelius Erik, Hölttä Mikko, Soininen Hilkka, Bjerke Maria, Zetterberg Henrik, Westerlund Anni, Herukka Sanna-Kaisa, Blennow Kaj, Mattsson Niklas. 2014. Neuromolecular medicine -
Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease
Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H0, Hansson O; Alzheimer's Disease Neuroimaging Initiative. 2014. JAMA psychiatry -
Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus
Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. 2014. PLoS ONE -
Exploring Alzheimer Molecular Pathology in Down's Syndrome Cerebrospinal Fluid
Portelius Erik, Soininen Hilkka, Andreasson Ulf, Zetterberg Henrik, Persson Rita, Karlsson Gösta, Blennow Kaj, Herukka Sanna-Kaisa, Mattsson Niklas. 2014. Neurodegenerative diseases -
Prognostic polypeptide blood plasma biomarkers of Alzheimer's Disease progression
Yang Hongqian, Lyutvinskiy Yaroslav, Herukka Sanna-Kaisa, Soininen Hilkka, Rutishauser Dorothea, Zubarev Roman A. 2014. Journal of Alzheimer's disease -
The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients
Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. 2014. Neurodegenerative diseases -
The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean?
Duits FH, Teunissen CE, Bouwman FH, Visser PJ, Mattsson N, Zetterberg H, Blennow K, Hansson O, Minthon L, Andreasen N, Marcusson J, Wallin A, Rikkert MO, Tsolaki M, Parnetti L, Herukka SK, Hampel H, De Leon MJ, Schröder J, Aarsland D, Blankenstein MA, Scheltens P, van der Flier WM. 2014. Alzheimer's & dementia -
Alzheimerin taudin varhaisdiagnostiikka
Seppälä T, Herukka S-K, Remes AM. 2013. Duodecim -
Blood plasma IgG Fc glycans are significantly altered in Alzheimer's Disease and progressive mild cognitive impairment
Lundström SL, Yang H, Lyutvinskiy Y, Rutishauser D, Herukka SK, Soininen H, Zubarev RA. 2013. Journal of Alzheimer's disease -
CSF biomarkers for Alzheimer's pathology and the effect size of APOE epsilon4
Andreasson U, Lautner R, Schott JM, Mattson N, Hansson P, Herukka S-K, Helisalmi S, Ewers M, Hampel H, Wallin A, Minthon L, Hardy J, Blennow K, Zetterberg H. 2013. Molecular psychiatry -
Comparing Predictors of Conversion to Alzheimer's Disease Using the Disease State Index
Muñoz-Ruiz MA, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Neurodegenerative diseases -
Comparison between clinical diagnosis and CSF biomarkers of Alzheimer Disease in elderly patients with late onset psychosis: Helsinki old age psychosis study (HOPS)
Seppälä TT, Louhija UM, Appelberg B, Herukka SK, Juva K. 2013. American journal of geriatric psychiatry -
Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's Disease and mild cognitive impairment
Munoz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka S-K, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H. 2013. Journal of Alzheimer's disease -
GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
Kämäläinen A, Viswanathan J, Natunen T, Helisalmi S, Kauppinen T, Pikkarainen M, Pursiheimo J-P, Alafuzoff I, Kivipelto M, Haapasalo A, Soininen H, Herukka S-K, Hiltunen M. 2013. Journal of Alzheimer's disease -
Genetic loci associated with Alzheimer's Disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort
Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S-K, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. 2013. PLoS ONE -
Predicting AD conversion: Comparison between prodromal AD guidelines and computer assisted PredictAD tool
Liu Y, Mattila J, Muñoz Ruiz MA, Paajanen T, Koikkalainen J, van Gils M, Herukka S-K, Waldemar G, Lötjönen J, Soininen H. 2013. PLoS ONE -
Age and diagnostic performance of Alzheimer disease CSF biomarkers
Mattson N, Rosen E, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka S-K, van der Flier WM, Blankenstein MA, Ewers M, Rich K, Kaiser E, Verbeek MM, Olde Rikkert M, Tsolaki M, Mulugeta E, Aarsland D, Visser PJ, Schröder J, Marcusson J, de Leon M, Hampel H, Scheltens P, Wallin A, Eriksdotter-Jönhagen M, Minthon L, Winblad B, Blennow K, Zetterberg H. 2012. Neurology -
Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment
Simonsen AH, Mattila J, Hejl A-M, Frederiksen KS, Herukka S-K, Hallikainen M, van Gils M, Lötjönen J, Soininen H, Waldemar G. 2012. Dementia and geriatric cognitive disorders -
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. 2012. Neurology -
Clinical use of CSF biomarkers in Alzheimer's disease
Zetterberg H, Lunn MP, Herukka S-K. 2012. Biomarkers in medicine -
Cognitive and neuropsychiatric symptom differences in early stages of Alzheimer's Disease: Kuopio ALSOVA Study
Hallikainen I, Koivisto AM, Paajanen T, Hiltunen A, Karppi P, Vanhanen M, Välimäki T, Herukka S-K, Soininen H, Hänninen T. 2012. Dementia and geriatric cognitive disorders -
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's Disease Dementia
Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka S-K, Steinacker P, Tawfik S, Tumani H, von Arnim CSF, Neumann M, Kretzschmar HA, Kulaksiz H, Lenter M, Wiltfang J, Ferger B, Hengerer B, Otto M. 2012. PLoS ONE -
Genetic analysis of genes involved in amyloid-beta degradation and clearance in Alzheimer's Disease
Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, Herukka S-K, Koivisto AM, Haapasalo A, Soininen H, Hiltunen M. 2012. Journal of Alzheimer's disease -
Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
Munoz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka S-K, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H. 2012. PLoS ONE -
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia
Lehnert S, Jesse S, Rist W, Steinacker P, Soininen H, Herukka S-K, Tumani H, Lenter M, Oeckl P, Ferger B, Hengerer B, Otto M. 2012. Experimental neurology -
Evidence for elevated cerebrospinal fluid ERK1/2 levels in Alzheimer Dementia
Spitzer P, Schieb H, Kamrowski-Kruck H, Otto M, Chiasserini D, Parnetti L, Herukka S-K, Schuchhardt J, Wiltfang J, Klafki H-W. 2011. International journal of alzheimers disease -
Longitudinal changes of CSF biomarkers in Alzheimer's Disease
Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka S-K. 2011. Journal of Alzheimer's disease -
Metabolome in progression to Alzheimer's disease
Oresic M, Hyötyläinen T, Herukka S-K, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H. 2011. Translational psychiatry -
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
Mattson N, Andreasson U, Persson S, Arai H, Dev Batish S, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlbors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka S-K. 2011. Alzheimer's & dementia -
Transcranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging
Casarotto S, Määttä S, Herukka SK, Pigorini A, Napolitani M, Gosseries O, Niskanen E, Könönen M, Mervaala E, Rosanova M, Soininen H, Massimini M. 2011. Neuroreport -
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
Mattsson N, Hansson O, Andreasen N, Parnetti L, Johnsson M, Herukka SK, van der Flier WM..., Marcusson J, de LEON M, Hampel H, Scheltens P, Pirttilä T, Wallin A, Eriksdotter Jönhagen M, Minthon L, Winblad B, Blennow K, Pirttilä T. 2009. JAMA : Journal of the American Medical Association -
Cerebrospinal fluid {beta}-amyloid 42 and Tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
Tapiola T, Alafuzoff I, Herukka S-K, Parkkinen L, Hartikainen P, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2009. Archives of neurology -
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T, Pirttilä T. 2009. Neurobiology of aging -
CSF Abeeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy
Herukka S-K, Pennanen C, Soininen H, Pirttilä T, Soininen H, Pirttilä T. 2008. Journal of Alzheimer's disease -
Genetic study evaluating LDLR polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Pirttilä T, Soininen H. 2008. Neurobiology of aging -
PET amyloid ligand (11C)PIB uptake and cerebrospinal fluid beta-amyloid in mild cognitive impairment
Koivunen J, Pirttilä T, Kemppainen N, Aalto S, Herukka S-K, Jauhiainen AM, Hänninen T, Hallikainen M, Någren K, Rinne JO, Soininen H, Pirttilä T, Soininen H. 2008. Dementia and geriatric cognitive disorders -
CSF Abeta42, tau and phosphorylated tau, APOE epsilon4 allele and MCI type in progressive MCI
Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T, Herukka S-K, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T. 2007. Neurobiology of aging -
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers
Lämsä R, Helisalmi S, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H. 2007. Dementia and geriatric cognitive disorders -
The association study between DHCR24 polymorphisms and Alzheimer's disease
Lämsä R, Helisalmi S, Hiltunen M, Herukka S-K, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H, Soininen H, Lämsä R, Helisalmi S, Herukka S-K, Pirttilä T, Vepsäläinen S. 2007. American journal of medical genetics. Part B : neuropsychiatric genetics -
Usefulness of Cerebrospinal Fluid Biomarkers in Diagnosis of Early Alzheimer's Disease
Herukka SK. 2007. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No -
Cerebrospinal fluid Abeta42, tau and phosphorylated tau predict progression in patients with cognitive impairment
Herukka S-K, Hallikainen M, Tervo S, Helisalmi S, Tapiola T, Soininen H, Pirttilä T, Hallikainen M, Tervo S, Helisalmi S, Soininen H, Pirttilä T. 2006. Serdi -
CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
Herukka S-K, Hallikainen M, Soininen H, Pirttilä T, Hallikainen M, Soininen H, Pirttilä T. 2005. Neurology -
Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
Liu L, Herukka S-K, Minkeviciene R, van Groen T, Tanila H. 2004. Neurobiology of disease -
Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
Liu L, Tapiola T, Herukka S-K, Heikkilä M, Tanila H. 2003. Neuroreport