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Activation of steroid hormone receptors by metabolism-disrupting chemicals
Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo. 2025. Toxicology and applied pharmacology. 499: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
Flury, Philipp; Krüger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sá Magalhães; Barbosa da Silva, Elany; Pöhlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O’Donoghue, Anthony J.; Yang, Shengyong; Sträter, Norbert; Gütschow, Michael; Laufer, Stefan A.; Müller, Christa E.; Pillaiyar, Thanigaimalai. 2025. Journal of medicinal chemistry. 68: 3626-3652 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of synthetic small molecules targeting the central regulator of <i>Salmonella</i> pathogenicity
Boudrioua, Abdelhakim; Joiner, Joe D.; Grin, Iwan; Kronenberger, Thales; Korotkov, Vadim S.; Steinchen, Wieland; Kohler, Alexander; Schminke, Sophie; Schulte, Julia-Christina; Pietsch, Michael; Naini, Arun; Kalverkamp, Simon; Hotop, Sven-Kevin; Coyle, Travis; Piselli, Claudio; Coles, Murray; Rox, Katharina; Marschal, Matthias; Bange, Gert; Flieger, Antje; Poso, Antti; Brönstrup, Mark; Hartmann, Marcus D.; Wagner, Samuel. 2025. Science advances. 11: 1-23 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Rudalska, Ramona; Harbig, Jule; Forster, Michael; Woelffing, Pascal; Esposito, Aylin; Kudolo, Mark; Botezatu, Adelina; Haller, Vanessa; Janssen, Nicole; Holzmayer, Samuel; Nahidino, Philipp; Trompak, Omelyan; Pantsar, Tatu; Kronenberger, Thales; Yurttas, Can; Rist, Elke; Weber, Alexander N. R.; Dahlke, Marc H.; Ott, German; Koenigsrainer, Alfred; Rothbauer, Ulrich; Maerklin, Melanie; Muerdter, Thomas; Schwab, Matthias; Singer, Stephan; Zender, Lars; Laufer, Stefan; Dauch, Daniel. 2025. Nature cancer. [Published: 16 January 2025]: 1-39 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors
Rashidian, Azam; Pitkänen, Sini; Maltarollo, Vinicius Goncalves; Schoppmeier, Ulrich; Shevchenko, Ekaterina; Medarametla, Prasanthi; Poso, Antti; Küblbeck, Jenni; Honkakoski, Paavo; Kronenberger, Thales. 2025. Journal of chemical information and modeling. [Online ahead of print April 8, 2025]: 1-15 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication
Monteiro, Adelson Héric A.; Freitas, Kátia M.; Montuori‐Andrade, Ana Clara M.; de Lima, Erick Bryan Sousa; Carvalho, Antônio Felipe S.; Cardoso, Camila; Lara, Edvaldo S.; Oliveira, Leonardo Camilo; Zaidan, Isabella; da Santos, Felipe Rocha Silva; Resende, Filipe; Souza‐Costa, Luiz Pedro; Queiroz‐Junior, Celso M.; Chaves, Ian de Meira; Nóbrega, Natália R. C.; Rabelo, Maria Beatriz O.; Rocha, Marina P.; Campana, Priscilla R. V.; Pádua, Rodrigo M.; Ferreira, Rafaela S.; Barreto, Luiza V.; Kronenber. 2025. Phytotherapy research. [First published: 18 March 2025]: 1-17 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity
Wang, Meng; Medarametla, Prasanthi; Kronenberger, Thales; Deingruber, Tomas; Brear, Paul; Figueroa, Wendy; Ho, Pok-Man; Krueger, Thomas; Pearce, James C.; Poso, Antti; Wakefield, James G.; Spring, David R.; Welch, Martin. 2025. Nature communications. 16: . 2334 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism
Reetz, Leonie; Schulze, Lukas; Kronenberger, Thales; Selim, Khaled A.; Schaefle, Timm; Dema, Taulant; Zipperer, Alexander; Mößner, Jens; Poso, Antti; Grond, Stephanie; Peschel, Andreas; Krismer, Bernhard. 2025. Mbio. 16: . e03571-24 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Dusek, Jan; Mejdrová, Ivana; Dohnalová, Klára; Smutny, Tomas; Chalupsky, Karel; Krutakova, Maria; Skoda, Josef; Rashidian, Azam; Pavkova, Ivona; Škach, Kryštof; Hricová, Jana; Chocholouskova, Michaela; Smutna, Lucie; Kamaraj, Rajamanikkam; Hroch, Miloš; Leníček, Martin; Mičuda, Stanislav; Pijnenburg, Dirk; van Beuningen, Rinie; Holčapek, Michal; Vítek, Libor; Ingelman-Sundberg, Magnus; Burk, Oliver; Kronenberger, Thales; Nencka, Radim; Pavek, Petr. 2025. Nature communications. 16: 1-21 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies
Galvez B. Pedreira, Júlia; Woelffing, Pascal; Schwarz, Moritz; Ebner, Simon; Rudalska, Ramona; Masberg, Benedikt; Esposito, Aylin; Rashidian, Azam; Schevchenko, Ekaterina; Smutna, Lucie; Pavek, Petr; Kublbeck, Jenni; Kronenberger, Thales; Zender, Lars; Lämmerhofer, Michael; Dauch, Daniel; Laufer, Stefan A. 2025. Journal of medicinal chemistry. [Ahead of Print March 24, 2025]: 1-17 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä