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Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
Flury, Philipp; Krüger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sá Magalhães; Barbosa da Silva, Elany; Pöhlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O’Donoghue, Anthony J.; Yang, Shengyong; Sträter, Norbert; Gütschow, Michael; Laufer, Stefan A.; Müller, Christa E.; Pillaiyar, Thanigaimalai. 2025. Journal of medicinal chemistry. 68: 3626-3652 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Rudalska, Ramona; Harbig, Jule; Forster, Michael; Woelffing, Pascal; Esposito, Aylin; Kudolo, Mark; Botezatu, Adelina; Haller, Vanessa; Janssen, Nicole; Holzmayer, Samuel; Nahidino, Philipp; Trompak, Omelyan; Pantsar, Tatu; Kronenberger, Thales; Yurttas, Can; Rist, Elke; Weber, Alexander N. R.; Dahlke, Marc H.; Ott, German; Koenigsrainer, Alfred; Rothbauer, Ulrich; Maerklin, Melanie; Muerdter, Thomas; Schwab, Matthias; Singer, Stephan; Zender, Lars; Laufer, Stefan; Dauch, Daniel. 2025. Nature cancer. [Published: 16 January 2025]: 1-39 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity
Wang, Meng; Medarametla, Prasanthi; Kronenberger, Thales; Deingruber, Tomas; Brear, Paul; Figueroa, Wendy; Ho, Pok-Man; Krueger, Thomas; Pearce, James C.; Poso, Antti; Wakefield, James G.; Spring, David R.; Welch, Martin. 2025. Nature communications. 16: . 2334 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Dusek, Jan; Mejdrová, Ivana; Dohnalová, Klára; Smutny, Tomas; Chalupsky, Karel; Krutakova, Maria; Skoda, Josef; Rashidian, Azam; Pavkova, Ivona; Škach, Kryštof; Hricová, Jana; Chocholouskova, Michaela; Smutna, Lucie; Kamaraj, Rajamanikkam; Hroch, Miloš; Leníček, Martin; Mičuda, Stanislav; Pijnenburg, Dirk; van Beuningen, Rinie; Holčapek, Michal; Vítek, Libor; Ingelman-Sundberg, Magnus; Burk, Oliver; Kronenberger, Thales; Nencka, Radim; Pavek, Petr. 2025. Nature communications. 16: 1-21 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach
Serafim, Mateus Sá Magalhães; Kronenberger, Thales; Rocha, Rafael Eduardo Oliveira; Rosa, Amanda Del Rio Abreu; Mello, Thaysa Lara Gonçalves; Poso, Antti; Ferreira, Rafaela Salgado; Abrahão, Jonatas Santos; Kroon, Erna Geessien; Mota, Bruno Eduardo Fernandes; Maltarollo, Vinícius Gonçalves. 2024. Journal of chemical information and modeling. 64: 393-411 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites
Crispim, Marcell; Verdaguer, Ignasi Bofill; Hernández, Agustín; Kronenberger, Thales; Fenollar, Àngel; Yamaguchi, Lydia Fumiko; Alberione, María Pía; Ramirez, Miriam; de Oliveira, Sandra Souza; Katzin, Alejandro Miguel; Izquierdo, Luis. 2024. PLoS pathogens. 20: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure–Activity Relationship and In Vivo Efficacy
Liu, Lawrence J; Francisco, Karol R; Sun, Yujie Uli; Serafim, Mateus Sá Magalhães; Amarasinghe, Dilini K; Teixeira, Thaiz R; Lucero, Bobby; Kronenberger, Thales; Elsayed, Waad; Elwakeel, Hala; Al-Hindy, Momen; Almaliti, Jehad; Gerwick, William H; O’Donoghue, Anthony J; Caffrey, Conor R. 2024. ACS infectious diseases. 10: 4182-4193 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity
Flury, Philipp; Breidenbach, Julian; Krüger, Nadine; Voget, Rabea; Schäkel, Laura; Si, Yaoyao; Krasniqi, Vesa; Calistri, Sara; Olfert, Matthias; Sylvester, Katharina; Rocha, Cheila; Ditzinger, Raphael; Rasch, Alexander; Pöhlmann, Stefan; Kronenberger, Thales; Poso, Antti; Rox, Katharina; Laufer, Stefan A; Müller, Christa E; Gütschow, Michael; Pillaiyar, Thanigaimalai. 2024. ACS pharmacology & translational science. 7: 493-514 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
Rak, Marcel; Menge, Amelie; Tesch, Roberta; Berger, Lena M; Balourdas, Dimitrios-Ilias; Shevchenko, Ekaterina; Kramer, Andreas; Elson, Lewis; Berger, Benedict-Tilman; Abdi, Ismahan; Wahl, Laurenz M; Poso, Antti; Kaiser, Astrid; Hanke, Thomas; Kronenberger, Thales; Joerger, Andreas C; Muller, Susanne; Knapp, Stefan. 2024. Journal of medicinal chemistry. 67: 3813-3842 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
Rashidian, Azam; Dusek, Jan; Drastik, Martin; Smutna, Lucie; Fritsche, Kristin; Braeuning, Albert; Pijnenburg, Dirk; van Beuningen, Rinie; Honkakoski, Paavo; Poso, Antti; Kronenberger, Thales; Pavek, Petr. 2024. Environmental science and technology. 58: 6913-6923 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä