Julkaisut
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A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2
Hillebrand, Laura; Wang, Guiqun; Rasch, Alexander; Masberg, Benedikt; Chaikuad, Apirat; Kronenberger, Thales; Günther, Ellen; Forster, Michael; Poso, Antti; Lämmerhofer, Michael; Laufer, Stefan A.; Knapp, Stefan; Gehringer, Matthias. 2025. RSC medicinal chemistry. [First published 01 Aug 2025]: 1-14 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Activation of steroid hormone receptors by metabolism-disrupting chemicals
Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo. 2025. Toxicology and applied pharmacology. 499: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
Flury, Philipp; Krüger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sá Magalhães; Barbosa da Silva, Elany; Pöhlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O’Donoghue, Anthony J.; Yang, Shengyong; Sträter, Norbert; Gütschow, Michael; Laufer, Stefan A.; Müller, Christa E.; Pillaiyar, Thanigaimalai. 2025. Journal of medicinal chemistry. 68: 3626-3652 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of Arylfuran and Carbohydrate Derivatives from the BraCoLi Library as Potential Zika Virus NS3pro Inhibitors
Oliveira, Fernanda Kelly Marcelino e; Murta Rezende Moraes Ribeiro, Beatriz; Goncalves de Oliveira, Ellen; Mol Sena Andrade Verzola, Marina; Kronenberger, Thales; Goncalves Maltarollo, Vinicius; Alves, Ricardo Jose; Barbosa de Oliveira, Renata; Salgado Ferreira, Rafaela; Santos Abrahao, Jonatas; Sa Magalhaes Serafim, Mateus. 2025. Future pharmacology. 5: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of synthetic small molecules targeting the central regulator of <i>Salmonella</i> pathogenicity
Boudrioua, Abdelhakim; Joiner, Joe D.; Grin, Iwan; Kronenberger, Thales; Korotkov, Vadim S.; Steinchen, Wieland; Kohler, Alexander; Schminke, Sophie; Schulte, Julia-Christina; Pietsch, Michael; Naini, Arun; Kalverkamp, Simon; Hotop, Sven-Kevin; Coyle, Travis; Piselli, Claudio; Coles, Murray; Rox, Katharina; Marschal, Matthias; Bange, Gert; Flieger, Antje; Poso, Antti; Brönstrup, Mark; Hartmann, Marcus D.; Wagner, Samuel. 2025. Science advances. 11: 1-23 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment
Waitman, Karoline B; Martin, Holli-Joi; Carlos, Jorge AEG.; Braga, Rodolpho C; Souza, Vinícius AM; Melo-Filho, Cleber C; Hilscher, Sebastian; Toledo, Mônica FZJ; Tavares, Maurício T; Costa-Lotufo, Letícia V; Machado-Neto, João A; Schutkowski, Mike; Sippl, Wolfgang; Kronenberger, Thales; Alves, Vinicius M; Parise-Filho, Roberto; Muratov, Eugene N. 2025. Computers in biology and medicine. 197: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Rudalska, Ramona; Harbig, Jule; Forster, Michael; Woelffing, Pascal; Esposito, Aylin; Kudolo, Mark; Botezatu, Adelina; Haller, Vanessa; Janssen, Nicole; Holzmayer, Samuel; Nahidino, Philipp; Trompak, Omelyan; Pantsar, Tatu; Kronenberger, Thales; Yurttas, Can; Rist, Elke; Weber, Alexander N R; Dahlke, Marc H; Ott, German; Koenigsrainer, Alfred; Rothbauer, Ulrich; Maerklin, Melanie; Muerdter, Thomas; Schwab, Matthias; Singer, Stephan; Zender, Lars; Laufer, Stefan; Dauch, Daniel. 2025. Nature cancer. 6: 259-277 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors
Rashidian, Azam; Pitkänen, Sini; Maltarollo, Vinicius Goncalves; Schoppmeier, Ulrich; Shevchenko, Ekaterina; Medarametla, Prasanthi; Poso, Antti; Küblbeck, Jenni; Honkakoski, Paavo; Kronenberger, Thales. 2025. Journal of chemical information and modeling. 65: 4148-4162 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
New players from the old chalcone scaffold: Synthesis, identification, and characterization of new potent ABCG2 inhibitors
Ruginsk, Bruna Estelita; Zattoni, Ingrid Fatima; Gomes De Oliveira, Arthur Henrique; Zanzarini, Isadora da Silva; de Moraes Rego, Fabiane Gomes; Picheth, Geraldo; Poso, Antti; Kronenberger, Thales; Goda, Katalin; Moure, Vivian Rotuno; Boumendjel, Ahcène; Valdameri, Glaucio. 2025. European journal of medicinal chemistry. 299: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication
Monteiro, Adelson Héric A.; Freitas, Kátia M.; Montuori‐Andrade, Ana Clara M.; de Lima, Erick Bryan Sousa; Carvalho, Antônio Felipe S.; Cardoso, Camila; Lara, Edvaldo S.; Oliveira, Leonardo Camilo; Zaidan, Isabella; da Santos, Felipe Rocha Silva; Resende, Filipe; Souza‐Costa, Luiz Pedro; Queiroz‐Junior, Celso M.; Chaves, Ian de Meira; Nóbrega, Natália R. C.; Rabelo, Maria Beatriz O.; Rocha, Marina P.; Campana, Priscilla R. V.; Pádua, Rodrigo M.; Ferreira, Rafaela S.; Barreto, Luiza V.; Kronenber. 2025. Phytotherapy research. 39: 2180-2196 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä