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A Twist of Fate: The Helix–Turn–Helix Motif in Pseudomonas aeruginosa ExsA Can Allosterically Stabilize the Ligand-Binding Domain
Medarametla, Prasanthi; Greenhalgh, Jack Calum; Pöhner, Ina; Welch, Martin; Poso, Antti; Kronenberger, Thales; Rahman, Taufiq, 2025, Journal of chemical information and modeling, 65, 22, 12448-12463. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2
Hillebrand, Laura; Wang, Guiqun; Rasch, Alexander; Masberg, Benedikt; Chaikuad, Apirat; Kronenberger, Thales; Günther, Ellen; Forster, Michael; Poso, Antti; Lämmerhofer, Michael; Laufer, Stefan A.; Knapp, Stefan; Gehringer, Matthias, 2025, RSC medicinal chemistry, 16, 10, 4906-4919. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Activation of steroid hormone receptors by metabolism-disrupting chemicals
Pitkänen, Sini; Niskanen, Jonna; Mysore, Raghavendra; Niskanen, Einari A; Palvimo, Jorma J; Pijnenburg, Dirk; van Beuningen, Rinie; Rashidian, Azam; Kronenberger, Thales; Poso, Antti; Levonen, Anna-Liisa; Küblbeck, Jenni; Honkakoski, Paavo, 2025, Toxicology and applied pharmacology, 499, 117335. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
Brianceau, Corentin; Wimmi, Stephan; Kronenberger, Thales; Diepold, Andreas, 2025, Nature communications, 16, 1, 9889. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
Flury, Philipp; Krüger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sá Magalhães; Barbosa da Silva, Elany; Pöhlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O’Donoghue, Anthony J.; Yang, Shengyong; Sträter, Norbert; Gütschow, Michael; Laufer, Stefan A.; Müller, Christa E.; Pillaiyar, Thanigaimalai, 2025, Journal of medicinal chemistry, 68, 3, 3626-3652. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of Arylfuran and Carbohydrate Derivatives from the BraCoLi Library as Potential Zika Virus NS3pro Inhibitors
Oliveira, Fernanda Kelly Marcelino e; Murta Rezende Moraes Ribeiro, Beatriz; Goncalves de Oliveira, Ellen; Mol Sena Andrade Verzola, Marina; Kronenberger, Thales; Goncalves Maltarollo, Vinicius; Alves, Ricardo Jose; Barbosa de Oliveira, Renata; Salgado Ferreira, Rafaela; Santos Abrahao, Jonatas; Sa Magalhaes Serafim, Mateus, 2025, Future pharmacology, 5, 1, 9. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of benzyl carbamate inhibitors of coronavirus M <sup>pro</sup> enzymes from a legacy collection of cysteine protease inhibitors
Sá Magalhães Serafim, Mateus; Kronenberger, Thales; Francisco, Karol R.; de Sousa Reis, Erik Vinicius; Gonçalves de Oliveira, Ellen; Marcelino e Oliveira, Fernanda Kelly; Serraglio Fortes, Isadora; Maciel Fernandes, Thaís Helena; Barbosa da Silva, Elany; Fajtova, Pavla; Skinner, Danielle E.; Syed, Rafay O; Lage de Siqueira-Neto, Jair; Poso, Antti; Fernandes Mota, Bruno Eduardo; Alves Coelho-dos-Reis, Jordana Grazziela; Santos Abrahão, Jônatas; Gonçalves Maltarollo, Vinícius; O’Donoghue, Anthony, 2025, Journal of enzyme inhibition and medicinal chemistry, 40, 1, 1-24. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Discovery of synthetic small molecules targeting the central regulator of <i>Salmonella</i> pathogenicity
Boudrioua, Abdelhakim; Joiner, Joe D.; Grin, Iwan; Kronenberger, Thales; Korotkov, Vadim S.; Steinchen, Wieland; Kohler, Alexander; Schminke, Sophie; Schulte, Julia-Christina; Pietsch, Michael; Naini, Arun; Kalverkamp, Simon; Hotop, Sven-Kevin; Coyle, Travis; Piselli, Claudio; Coles, Murray; Rox, Katharina; Marschal, Matthias; Bange, Gert; Flieger, Antje; Poso, Antti; Brönstrup, Mark; Hartmann, Marcus D.; Wagner, Samuel, 2025, Science advances, 11, 15, 1-23. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment
Waitman, Karoline B; Martin, Holli-Joi; Carlos, Jorge AEG.; Braga, Rodolpho C; Souza, Vinícius AM; Melo-Filho, Cleber C; Hilscher, Sebastian; Toledo, Mônica FZJ; Tavares, Maurício T; Costa-Lotufo, Letícia V; Machado-Neto, João A; Schutkowski, Mike; Sippl, Wolfgang; Kronenberger, Thales; Alves, Vinicius M; Parise-Filho, Roberto; Muratov, Eugene N, 2025, Computers in biology and medicine, 197, Part A, 110990. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Rudalska, Ramona; Harbig, Jule; Forster, Michael; Woelffing, Pascal; Esposito, Aylin; Kudolo, Mark; Botezatu, Adelina; Haller, Vanessa; Janssen, Nicole; Holzmayer, Samuel; Nahidino, Philipp; Trompak, Omelyan; Pantsar, Tatu; Kronenberger, Thales; Yurttas, Can; Rist, Elke; Weber, Alexander N R; Dahlke, Marc H; Ott, German; Koenigsrainer, Alfred; Rothbauer, Ulrich; Maerklin, Melanie; Muerdter, Thomas; Schwab, Matthias; Singer, Stephan; Zender, Lars; Laufer, Stefan; Dauch, Daniel, 2025, Nature cancer, 6, 2, 259-277. A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä