Hermoston farmakologia ja lääkekohteet tutkimuskonsortio

01.01.2022 -

Tutkimusryhmä

Please see English site.

Rahoittaja(t)

Päärahoittaja

Suomen Akatemia

Ajanjakso

01.01.2022 -

Ryhmän jäsenet - UEF

Johtaja(t)

Professorit

Vanhemmat tutkijat

Tutkijatohtorit

Väitöskirjatutkijat

Teknikot

Yliopiston lehtori

Markus Storvik Yliopistonlehtori, Terveystieteiden tiedekunta, Farmasian laitos

Muut ryhmän jäsenet

M.Sc. Students: Konsta Rintala, Niklas Kämppi

Yhteistyö UEF:n tutkimusryhmien kanssa

Julkaisut

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors Pätsi, Henri T.; Kilpeläinen, Tommi P.; Auno, Samuli; Dillemuth, Pyry M. J.; Arja, Khaled; Lahtela-Kakkonen, Maija K.; Myöhänen, Timo T.; Wallén, Erik A. A.. 2021. 2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors Acs medicinal chemistry letters 12 10: 1578-1584. 2021
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy Cui, Hengjing; Kilpeläinen, Tommi; Zouzoula, Lydia; Auno, Samuli; Trontti, Kalevi; Kurvonen, Sampo; Norrbacka, Susanna; Hovatta, Iiris; Jensen, Poul Henning; Myöhänen, Timo T.. 2021. Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy Journal of cellular and molecular medicine 25 20: 9634-9646. 2021
Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A Eteläinen, T; Kulmala, V; Svarcbahs, R; Jäntti, M; Myohänen, T T. 2021. Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A Free radical biology and medicine 169: 14-23. 2021
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing Suh, Susie; Choi, Elliot H; Leinonen, Henri; Foik, Andrzej T; Newby, Gregory A; Yeh, Wei-His; Dong, Zhiqian; Kiser, Philip D; Lyon, David C; Liu, David R; Palczewski, Krzysztof. 2021. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing Nature biomedical engineering 5 2: 169-178. 2021
Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease Leinonen, Henri; Pham, Nguyen C; Boyd, Taylor; Santoso, Johanes; Palczewski, Krzysztof; Vinberg, Frans. 2020. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease eLife 9: e59422. 2020
A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K.. 2019. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness Investigative ophthalmology and visual science 60 5: 1442-1453. 2019
Vision in laboratory rodents - Tools to measure it and implications for behavioral research Leinonen, H; Tanila, H. 2018. Vision in laboratory rodents - Tools to measure it and implications for behavioral research BEHAVIOURAL BRAIN RESEARCH 352: 172-182. 2018
Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy Leinonen Henri, Keksa-Goldsteine Velta, Ragauskas Symantas, Kohlmann Philip, Signh Yajuvinder, Savchencko Ekaterina, Puranen Jooseppi, Malm Tarja, Kalesnykas Giedrius, Koistinaho Jari, Tanila Heikki, Kanninen Katja M. 2017. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Scientific Reports 7: 1597. 2017