Arto Mannermaa
Professori
Kliinisen lääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta
arto.mannermaa@uef.fi | 040 355 2752
Tutkimusryhmät
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Itä-Suomen Genomikeskus (ISGK) 02.03.2009 - -
Itä-Suomen syöpäkeskus (CCEF) 01.01.2022 - -
Molecular Pathology and Genetics of Cancer 01.01.2022 - -
Pohjois-Savon ihosyöpäohjelma (PoSiho)
Projektit
Julkaisut
279/279 kappaletta-
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha. 2025. Fluids and barriers of the cns. 22: . 17 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A Multi-View Deep Evidential Learning Approach for Mammogram Density Classification
Gudhe, Naga Raju; Mazen, Sudah; Sund, Reijo; Kosma, Veli-Matti; Behravan, Hamid; Mannermaa, Arto. 2024. IEEE access. 12: 67889-67909 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A dataset of mammography images with area-based breast density values, breast area, and dense tissue segmentation masks
Behravan, Hamid; Gudhe, Naga Raju; Okuma, Hidemi; Sudah, Mazen; Mannermaa, Arto. 2024. Data in brief. 57: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Circulating Micro-RNAs Predict the Risk of Recurrence in Triple-Negative Breast Cancer
Kujala, Jouni; Tengström, Maria; Heikkinen, Sami; Taipale, Mari; Kosma, Veli-Matti; Hartikainen, Jaana M; Mannermaa, Arto. 2024. Cells. 13: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset
Davidson, Aimee L; Michailidou, Kyriaki; Parsons, Michael T; Fortuno, Cristina; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Naven, Marc; Abubakar, Mustapha; Ahearn, Thomas U; Alonso, M Rosario; Andrulis, Irene L; Antoniou, Antonis C; Auvinen, Päivi; Behrens, Sabine; Bermisheva, Marina A; Bogdanova, Natalia V; Bojesen, Stig E; Brüning, Thomas; Byers, Helen J; Camp, Nicola J; Campbell, Archie; Castelao, Jose E; Cessna, Melissa H; Chang-Claude, Jenny; Chanock, Stephen J; Chenevix-Trench, Georgia; NBC. 2024. American journal of human genetics. 111: 2059-2069 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
Yiangou, Kristia; Mavaddat, Nasim; Dennis, Joe; Zanti, Maria; Wang, Qin; Bolla, Manjeet K; Abubakar, Mustapha; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Baten, Adinda; Behrens, Sabine; Bermisheva, Marina; Berrington de Gonzalez, Amy; Białkowska, Katarzyna; Boddicker, Nicholas; Bodelon, Clara; Bogdanova, Natalia V; Bojesen, Stig E; Brantley, Kristen D; Brauch, Hiltrud; Brenner, Hermann; Camp, Nicola J. 2024. Breast cancer research. 26: . 189 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort
Räsänen, Joel; Heikkinen, Sami; Mäklin, Kiira; Lipponen, Anssi; Kuulasmaa, Teemu; Mehtonen, Juha; Korhonen, Ville E; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Celine; Oinas, Minna; Avellan, Cecilia; Frantzén, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M; Julkunen, Valtteri; Portaankorva, Anne M; Mannermaa, Arto; Soininen, Hilkka; Helisalmi, Seppo; Jääskeläinen. 2024. Neurology. 103: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Kentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; Mendes de Oliveira, Edson; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bra. 2024. Nature genetics. 56: 1397-1411 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A FinnGen pilot clinical recall study for Alzheimer’s disease
Julkunen, Valtteri; Schwarz, Claudia; Kalapudas, Juho; Hallikainen, Merja; Piironen, Aino-Kaisa; Mannermaa, Arto; Kujala, Hanna; Laitinen, Timo; Kosma, Veli-Matti; Paajanen, Teemu I.; Kälviäinen, Reetta; Hiltunen, Mikko; Herukka, Sanna-Kaisa; Kärkkäinen, Sari; Kokkola, Tarja; Urjansson, Mia; FinnGen; Perola, Markus; Palotie, Aarno; Vuoksimaa, Eero; Runz, Heiko. 2023. Scientific reports. 13: . 12641 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: Application to BRCA1 and BRCA2
Zanti, Maria; O'Mahony, Denise G.; Parsons, Michael T.; Li, Hongyan; Dennis, Joe; Aittomäkkiki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Aronson, Kristan J.; Augustinsson, Annelie; Becher, Heiko; Bojesen, Stig E.; Bolla, Manjeet K.; Brenner, Hermann; Brown, Melissa A.; Buys, Saundra S.; Canzian, Federico; Caputo, Sandrine M.; Castelao, Jose E.; Chang-Claude, Jenny; GC-HBOC study Collaborators; Czene, Kamila; Daly, Mary B.; De Nicolo, Arcangela; Devilee, Peter; Dörk, Thilo; Dunning, Ali. 2023. Human mutation. 2023: . 9961341 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Mueller, Stefanie H.; Lai, Alvina G.; Valkovskaya, Maria; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Abu-Ful, Zomoruda; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baert, Thais; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Bonanni, Bernardo; Brenner. 2023. Genome medicine. 15: . 7 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival
Morra, Anna; Schreurs, Maartje A. C.; Andrulis, Irene L.; Anton-Culver, Hoda; Augustinsson, Annelie; Beckmann, Matthias W.; Behrens, Sabine; Bojesen, Stig E.; Bolla, Manjeet K.; Brauch, Hiltrud; Broeks, Annegien; Buys, Saundra S.; Camp, Nicola J.; Castelao, Jose E.; Cessna, Melissa H.; Chang-Claude, Jenny; Chung, Wendy K.; Colonna, Sarah, V; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Dennis, Joe; Devilee, Peter; Doerk, Thilo; Dunning, Alison M.; Dwek, Miriam; E. 2023. Cancer medicine. 12: 16142-16162 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel
Levi, Hagai; Carmi, Shai; Rosset, Saharon; Yerushalmi, Rinat; Zick, Aviad; Yablonski-Peretz, Tamar; The BCAC Consortium; Wang, Qin; Bolla, Manjeet K; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Ahearn, Thomas; Andrulis, Irene L; Anton-Culver, Hoda; Antoniou, Antonis C; Arndt, Volker; Augustinsson, Annelie; Auvinen, Päivi; Beane Freeman, Laura; Beckmann, Matthias; Behrens, Sabine; Bermisheva, Marina; Bodelon, Clara; Bogdanova, Natalia V; Bojesen, Stig E; Brenner, Hermann; Byers, Helen; Camp. 2023. Journal of medical genetics. 60: 1186-1197 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women
Figlioli, Gisella; Billaud, Amandine; Ahearn, Thomas U.; Antonenkova, Natalia N.; Becher, Heiko; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blok, Marinus J.; Bogdanova, Natalia V.; Bonanni, Bernardo; Burwinkel, Barbara; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Cessna, Melissa H.; Chanock, Stephen J.; Czene, Kamila; Devilee, Peter; Dörk, Thilo; Engel, Christoph; Eriksson, Mikael; Fasching, Peter A.; Figueroa, Jonine D.; Gabrielson, Marike; Gago-Domin. 2023. European journal of human genetics. 31: 578-587 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
FinnGen provides genetic insights from a well-phenotyped isolated population
Kurki, Mitja I.; Karjalainen, Juha; Palta, Priit; Sipilä, Timo P.; Kristiansson, Kati; Donner, Kati M.; Reeve, Mary P.; Laivuori, Hannele; Aavikko, Mervi; Kaunisto, Mari A.; Loukola, Anu; Lahtela, Elisa; Mattsson, Hannele; Laiho, Päivi; Della Briotta Parolo, Pietro; Lehisto, Arto A.; Kanai, Masahiro; Mars, Nina; Rämö, Joel; Kiiskinen, Tuomo; Heyne, Henrike O.; Veerapen, Kumar; Rüeger, Sina; Lemmelä, Susanna; Zhou, Wei; Ruotsalainen, Sanni; Pärn, Kalle; Hiekkalinna, Tero; Koskelainen, Sami; Paaja. 2023. Nature. 613: 508-518 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Nuclei instance segmentation from histopathology images using Bayesian dropout based deep learning
Gudhe, Naga Raju; Kosma, Veli-Matti; Behravan, Hamid; Mannermaa, Arto. 2023. Bmc medical imaging. 23: . 162 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants
Muranen, Taru A.; Morra, Anna; Khan, Sofia; Barnes, Daniel R.; Bolla, Manjeet K.; Dennis, Joe; Keeman, Renske; Leslie, Goska; Parsons, Michael T.; Wang, Qin; Ahearn, Thomas U.; Aittomäki, Kristiina; Andrulis, Irene L.; Arun, Banu K.; Behrens, Sabine; Bialkowska, Katarzyna; Bojesen, Stig E.; Camp, Nicola J.; Chang-Claude, Jenny; Czene, Kamila; Devilee, Peter; Domchek, Susan M.; Dunning, Alison M.; Engel, Christoph; Evans, D. Gareth; Gago-Dominguez, Manuela; García-Closas, Montserrat; Gerdes, Anne. 2023. npj breast cancer. 9: . 37 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Predicting cell type counts in whole slide histology images using evidential multi-task learning
Gudhe, Naga Raju; Sudah, Mazen; Mannermaa, Arto; Kosma, Veli-Matti; Behravan, Hamid. Teoksessa: Tomaszewski, John E; Ward, Aaron D(toim.) , 2023. Medical Imaging 2023: Digital and Computational Pathology. s. 239-247. SPIE A4 Artikkeli konferenssijulkaisussa -
Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases
Figlioli, Gisella; Billaud, Amandine; Wang, Qin; Bolla, Manjeet K.; Dennis, Joe; Lush, Michael; Kvist, Anders; Adank, Muriel A.; Ahearn, Thomas U.; Antonenkova, Natalia N.; Auvinen, Päivi; Behrens, Sabine; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Bonanni, Bernardo; Brüning, Thomas; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Cessna, Melissa H.; NBCS Collaborators; Czene, Kamila; Devilee, Peter; Dörk, Thilo; Eriksson, Mikael; Fasching, Peter A.; Flyger, Henrik; Gabri. 2023. Cancers. 15: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Suusyövän epigenetiikka
Malinen Hanna; Mannermaa Arto; Siponen Maria. 2023. Suomen hammaslääkärilehti. 30: 30-36 A2 Katsausartikkeli tieteellisessä aikakauslehdessä -
The impact of coding germline variants on contralateral breast cancer risk and survival
Morra, Anna; Mavaddat, Nasim; Muranen, Taru A.; Ahearn, Thomas U.; Allen, Jamie; Andrulis, Irene L.; Auvinen, Päivi; Becher, Heiko; Behrens, Sabine; Blomqvist, Carl; Bojesen, Stig E.; Bolla, Manjeet K.; Brauch, Hiltrud; Camp, Nicola J.; Carvalho, Sara; Castelao, Jose E.; Cessna, Melissa H.; Chang-Claude, Jenny; Chenevix-Trench, Georgia; NBCS Collaborators; Czene, Kamila; Decker, Brennan; Dennis, Joe; Dörk, Thilo; Dorling, Leila; Dunning, Alison M.; Ekici, Arif B.; Eriksson, Mikael; Evans, D. Gar. 2023. American journal of human genetics. 110: 475-486 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
Jääskeläinen, Minna M; Tiainen, Satu; Siiskonen, Hanna; Ahtiainen, Maarit; Kuopio, Teijo; Rönkä, Aino; Kettunen, Tiia; Hämäläinen, Kirsi; Rilla, Kirsi; Harvima, Ilkka; Mannermaa, Arto; Auvinen, Päivi. 2023. Breast cancer research and treatment. 201: 183-192 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women
Wang, Xiaoliang; Chen, Hongjie; Kapoor, Pooja Middha; Su, Yu-Ru; Bolla, Manjeet K.; Dennis, Joe; Dunning, Alison M.; Lush, Michael; Wang, Qin; Michailidou, Kyriaki; Pharoah, Paul D.P.; Hopper, John L.; Southey, Melissa C.; Koutros, Stella; Freeman, Laura E. Beane; Stone, Jennifer; Rennert, Gad; Shibli, Rana; Murphy, Rachel A.; Aronson, Kristan; Guénel, Pascal; Truong, Thérèse; Teras, Lauren R.; Hodge, James M.; Canzian, Federico; Kaaks, Rudolf; Brenner, Hermann; Arndt, Volker; Hoppe, Reiner; Lo,. 2022. Cancer research communications. 2: 211-219 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Area-based breast percentage density estimation in mammograms using weight-adaptive multitask learning
Gudhe, Naga Raju; Behravan, Hamid; Sudah, Mazen; Okuma, Hidemi; Vanninen, Ritva; Kosma, Veli-Matti; Mannermaa, Arto. 2022. Scientific reports. 12: . 12060 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Breast cancer risks associated with missense variants in breast cancer susceptibility genes
Dorling, Leila; Carvalho, Sara; Allen, Jamie; Parsons, Michael T.; Fortuno, Cristina; González-Neira, Anna; Heijl, Stephan M.; Adank, Muriel A.; Ahearn, Thomas U.; Andrulis, Irene L.; Auvinen, Päivi; Becher, Heiko; Beckmann, Matthias W.; Behrens, Sabine; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Bremer, Michael; Briceno, Ignacio; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Chenevix-Trench, Georgia; Collée, . 2022. Genome medicine. 14: . 51 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast Cancer Tumors
Kujala, Jouni; Hartikainen, Jaana M.; Tengström, Maria; Sironen, Reijo; Auvinen, Päivi; Kosma, Veli Matti; Mannermaa, Arto. 2022. Cancers. 14: . 1332 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Ahearn, Thomas U.; Zhang, Haoyu; Michailidou, Kyriaki; Milne, Roger L.; Bolla, Manjeet K.; Dennis, Joe; Dunning, Alison M.; Lush, Michael; Wang, Qin; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J.; Auer, Paul L.; Augustinsson, Annelie; Baten, Adinda; Becher, Heiko; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bojesen, Stig E.; Bonanni, Bernardo; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brooks-Wilson, Angela; Brüning, Thoma. 2022. Breast cancer research. 24: . 2 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies
Jung, Audrey Y; Ahearn, Thomas U; Behrens, Sabine; Middha, Pooja; Bolla, Manjeet K; Wang, Qin; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Beane Freeman, Laura E; Becher, Heiko; Brenner, Hermann; Canzian, Federico; Carey, Lisa A; CTS Consortium; Czene, Kamila; Eliassen, A Heather; Eriksson, Mikael; Evans, D Gareth; Figueroa, Jonine D; Fritschi, Lin; Gabrielson, Marike; Giles, Graham G; Guénel, Pascal; Hadjisavvas, Andreas; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann. 2022. Journal of the national cancer institute. 114: 1706-1719 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M.. 2022. Scientific reports. 12: . 22614 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
Ruotsalainen, Sanni E.; Surakka, Ida; Mars, Nina; Karjalainen, Juha; Kurki, Mitja; Kanai, Masahiro; Krebs, Kristi; Graham, Sarah; Mishra, Pashupati P.; Mishra, Binisha H.; Sinisalo, Juha; Palta, Priit; Lehtimäki, Terho; Raitakari, Olli; Esko, Tõnu; Metspalu, Andres; Mägi, Reedik; Nelis, Mari; Milani, Lili; Matsuda, Koichi; Yamanashi, Yuji; Furukawa, Yoichi; Morisaki, Takayuki; Murakami, Yoshinori; Kamatani, Yoichiro; Muto, Kaori; Nagai, Akiko; Obara, Wataru; Yamaji, Ken; Takahashi, Kazuhisa; Asa. 2022. Communications biology. 5: . 802 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes
Tamlander, Max; Mars, Nina; Pirinen, Matti; Palotie, Aarno; Daly, Mark; Riley-Gills, Bridget; Jacob, Howard; Paul, Dirk; Runz, Heiko; John, Sally; Plenge, Robert; Maranville, Joseph; Okafo, George; Lawless, Nathan; Salminen-Mankonen, Heli; McCarthy, Mark; Hunkapiller, Julie; Ehm, Meg; Auro, Kirsi; Longerich, Simonne; Fox, Caroline; Mälarstig, Anders; Klinger, Katherine; Raipal, Deepak; Green, Eric; Graham, Robert; Yang, Robert; O’Donnell, Chris; Mäkelä, Tomi; Kaprio, Jaakko; Virolainen, Petri; H. 2022. Communications biology. 5: . 158 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions
Suhonen, Ville; Siiskonen, Hanna; Suni, Maunu; Rummukainen, Jaana; Mannermaa, Arto; Harvima, Ilkka T.. 2022. European journal of dermatology. 32: 187-194 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes
Breast Cancer Association Consortium; Mavaddat, Nasim; Dorling, Leila; Carvalho, Sara; Allen, Jamie; González-Neira, Anna; Keeman, Renske; Bolla, Manjeet K.; Dennis, Joe; Wang, Qin; Ahearn, Thomas U.; Andrulis, Irene L.; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Briceno, Ignacio; Brüning, Thomas; Camp, Nicola J.; Campbell, Archie; Castelao, Jose E.; Chang-Claude, Jenny; Chanock, Stephen J.; Chenevix-Tren. 2022. JAMA oncology. 8: A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study
Dixon-Suen, Suzanne C; Lewis, Sarah J; Martin, Richard M; English, Dallas R; Boyle, Terry; Giles, Graham G; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Lush, Michael; Ahearn, Thomas U; Ambrosone, Christine B; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Auvinen, Päivi; Beane Freeman, Laura E; Becher, Heiko; Beckmann, Matthias W; Behrens, Sabine; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bona. 2022. British journal of sports medicine. 56: 1157-1170 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
Rare germline copy number variants (CNVs) and breast cancer risk
Dennis, Joe; Tyrer, Jonathan P.; Walker, Logan C.; Michailidou, Kyriaki; Dorling, Leila; Bolla, Manjeet K.; Wang, Qin; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Castelao, Jose E.; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Clarke, Christine L.; Kristensen, . 2022. Communications biology. 5: . 65 A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä -
A case-only study to identify genetic modifiers ofbreast cancer risk for BRCA1/BRCA2mutationcarriers
Coignard, Juliette; Lush, Michael; Beesley, Jonathan; O'Mara, Tracy A; Dennis, Joe; Tyrer, Jonathan P; Barnes, Daniel R; McGuffog, Lesley; Leslie, Goska; Bolla, Manjeet K; Adank, Muriel A; Agata, Simona; Ahearn, Thomas; Aittomäki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Arnold, Norbert; Aronson, Kristan J.; Arun, Banu K. et al [Incl. Kosma, Veli-Matti; Mannermaa, Arto]. 2021. Nature communications -
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Morra, Anna; Escala-Garcia, Maria; Beesley, Jonathan; Keeman, Renske; Canisius, Sander; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Auer, Paul L; Augustinsson, Annelie; Beane Freeman, Laura E; Becher, Heiko; Beckmann, Matthias W; Behrens, Sabine; Bojesen, Stig E; Bolla, Manjeet K; Brenner, Hermann; Brüning, Thomas; Buys, Saundra S; et al; [incl. Hartikainen, Jaana; Mannermaa, Arto]. 2021. Breast cancer research -
Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium
Morra, Anna; Jung, Audrey Y; Behrens, Sabine; Keeman, Renske; Ahearn, Thomas U; Anton-Culver, Hoda; Arndt, Volker; Augustinsson, Annelie; Auvinen, Päivi K; Freeman, Laura E Beane; Becher, Heiko; Beckmann, Matthias W; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Brenner, Hermann; Briceno, Ignacio; Brucker, Sara Y; Camp, Nicola J; Campa, Daniele et al. [incl. Mannermaa, Arto]. 2021. Cancer epidemiology biomarkers and prevention -
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
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Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J et al [incl. Hartikainen Juha, Mannermaa Arto, Tengström Maria]. 2017. Nature genetics -
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Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers
Schmidt MK, Hogervorst F, van Hien R, Cornelissen S, Broeks A, Adank MA, Meijers H, Waisfisz Q, Hollestelle A, Schutte M, van den Ouweland A, Hooning M, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Arndt V, Bermisheva M, Bogdanova NV, Bolla MK et al. 2016. Journal of clinical oncology -
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Peto J, Dos-Santos-Silva I et al. 2016. Human molecular genetics -
Association of breast cancer risk with genetic variants showing differential allelic expression: identification of a novel breast cancer susceptibility locus at 4q21.
Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S, Lemaçon A, Droit A, Andrulis IL, Anton-Culver H, Arndt V, Baynes C, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borresen-Dale AL, Brand JS, Brauch H, Brenner H, Broeks A, Burwinkel B, Chang-Claude J, Collaborators N, Couch FJ, Cox A, Cross SS, Czene K, Darabi H, Dennis J, Devilee P, Dörk T, Dos-Santos-Silva I, Eriksson M, Fasching PA, Figueroa J, Flyger H, García-Closas M, Giles GG, Goldberg MS, Kataja V, Mannermaa A, et al.. 2016. Oncotarget -
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry
Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B, Long J, Shu XO, Schmidt MK, Milne RL, García-Closas M, Chang-Claude J, Lindstrom S, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW et al. 2016. Cancer causes and control -
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M et al. 2016. Nature genetics -
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation
Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A ( incl. Mannermaa Arto, Veli-Matti Kosma). 2016. American journal of human genetics -
FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome
Kiiski JI, Fagerholm R, Tervasmäki A, Pelttari LM, Khan S, Jamshidi M, Mantere T, Pylkäs K, Bartek J, Bartkova J, Mannermaa A, Tengström M, Kosma VM, Winqvist R, Kallioniemi A, Aittomäki K, Blomqvist C, Nevanlinna H. 2016. International journal of cancer -
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
Darabi H, Beesley J, Droit A, Kar S, Nord S, Moradi Marjaneh M, Soucy P, Michailidou K, Ghoussaini M, Fues Wahl H, Bolla MK, Wang Q, Dennis J, Alonso MR, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV et al (incl Kosma Veli-matti, Mannermaa Arto). 2016. Scientific reports -
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus
Horne HN, Chung CC, Zhang H, Yu K, Prokunina-Olsson L, Michailidou K, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I et al. (Incl. Kosma Veli-Matti, Mannermaa Arto). 2016. PLoS ONE -
Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, Shu XO, Beesley J, Kar S, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Zhao Z, Guo X, Benitez J et al. 2016. International journal of cancer -
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB et al (incl Kosma Veli-Matti, Mannermaa Arto). 2016. Nature communications -
Genes associated with histopathologic features of triple negative breast tumors predict molecular subtypes
Purrington KS, Visscher DW, Wang C, Yannoukakos D, Hamann U, Nevanlinna H, Cox A, Giles GG, Eckel-Passow JE, Lakis S, Kotoula V, Fountzilas G, Kabisch M, Rüdiger T, Heikkilä P, Blomqvist C, Cross SS, Southey MC, Olson JE, Gilbert J et al. 2016. Breast cancer research and treatment -
Genetic predisposition to ductal carcinoma in situ of the breast
Petridis Christos, Brook Mark N, Shah Vandna, Kohut Kelly, Gorman Patricia, Caneppele Michele, Levi Dina, Papouli Efterpi, Orr Nick, Cox Angela, Cross Simon S, Dos-Santos-Silva Isabel, Peto Julian, Swerdlow Anthony, Schoemaker Minouk J, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Benitez Javier et al. 2016. Breast cancer research -
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
Guo Y, Warren Andersen S, Shu XO, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL, Schmidt MK, Chang-Claude J, Dunning A, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J et al. (incl. Kosma Veli-Matti, Mannermaa Arto). 2016. PLoS medicine -
High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium
Abubakar Mustapha, Howat William J, Daley Frances, Zabaglo Lila, McDuffus Leigh-Anne, Blows Fiona, Coulson Penny, Raza Ali H, Benitez Javier, Milne Roger, Brenner Herman, Stegmaier Christa, Mannermaa Arto, Chang-Claude Jenny, Rudolph Anja, Sinn Peter, Couch Fergus J, Tollenaar Rob AEM, Devilee Peter, Figueroa Jonine et al. 2016. The journal of pathology : Clinical research -
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Couch Fergus J, Kuchenbaecker Karoline B, Michailidou Kyriaki, Mendoza-Fandino Gustavo A, Nord Silje, Lilyquist Janna, Olswold Curtis, Hallberg Emily, Agata Simona, Ahsan Habibul, Aittomäki Kristiina, Ambrosone Christine, Andrulis Irene L, Anton-Culver Hoda, Arndt Volker, Arun Banu K, Arver Brita, Barile Monica, Barkardottir Rosa B, Barrowdale Daniel et al. 2016. Nature communications -
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
Zeng Chenjie, Guo Xingyi, Long Jirong, Kuchenbaecker Karoline B, Droit Arnaud, Michailidou Kyriaki, Ghoussaini Maya, Kar Siddhartha, Freeman Adam, Hopper John L, Milne Roger L, Bolla Manjeet K, Wang Qin, Dennis Joe, Agata Simona, Ahmed Shahana, Aittomäki Kristiina, Andrulis Irene L, Anton-Culver Hoda, Antonenkova Natalia N et al. 2016. Breast cancer research -
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle Antoinette, van der Baan Frederieke H, Berchuck Andrew, Johnatty Sharon E, Aben Katja K, Agnarsson Bjarni A, Aittomäki Kristiina, Alducci Elisa, Andrulis Irene L, Anton-Culver Hoda, Antonenkova Natalia N, Antoniou Antonis C, Apicella Carmel, Arndt Volker, Arnold Norbert, Arun Banu K, Arver Brita, Ashworth Alan, Baglietto Laura, Balleine Rosemary et al. (incl. Jaana. 2016. Gynecologic oncology -
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing
Easton Douglas F, Lesueur Fabienne, Decker Brennan, Michailidou Kyriaki, Li Jun, Allen Jamie, Luccarini Craig, Pooley Karen A, Shah Mitul, Bolla Manjeet K, Wang Qin, Dennis Joe, Ahmad Jamil, Thompson Ella R, Damiola Francesca, Pertesi Maroulio, Voegele Catherine, Mebirouk Noura, Robinot Nivonirina, Durand Geoffrey et al. 2016. Journal of medical genetics -
PALB2, CHEK2 and ATM rare variants and cancer risk: Data from COGS
Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F, Tischkowitz M, Foulkes WD, Dennis J, Michailidou K, van Rensburg EJ, Heikkinen T, Nevanlinna H, Hopper JL, Dörk T, Claes KB, Reis-Filho J, Teo ZL, Radice P, Catucci I, Peterlongo P et al. 2016. Journal of medical genetics -
Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association Consortium
Muranen TA, Blomqvist C, Dörk T, Jakubowska A, Heikkilä P, Fagerholm R, Greco D, Aittomäki K, Bojesen SE, Shah M, Dunning AM, Rhenius V, Hall P, Czene K, Brand JS, Darabi H, Chang-Claude J, Rudolph A, Nordestgaard BG, Couch FJ et al (incl. Mannermaa Arto). 2016. Breast cancer research -
Prognostic value of automated KI67 scoring in breast cancer: A centralised evaluation of 8088 patients from 10 study groups
Abubakar M, Orr N, Daley F, Coulson P, Ali HR, Blows F, Benitez J, Milne R, Brenner H, Stegmaier C, Mannermaa A, Chang-Claude J, Rudolph A, Sinn P, Couch FJ, Devilee P, Tollenaar RAEM, Seynaeve C, Figueroa J, Sherman ME et al. 2016. Breast cancer research -
RAD51B in Familial Breast Cancer
Pelttari Liisa M, Khan Sofia, Vuorela Mikko, Kiiski Johanna I, Vilske Sara, Nevanlinna Viivi, Ranta Salla, Schleutker Johanna, Winqvist Robert, Kallioniemi Anne, Dörk Thilo, Bogdanova Natalia V, Figueroa Jonine, Pharoah Paul DP, Schmidt Marjanka K, Dunning Alison M, García-Closas Montserrat, Bolla Manjeet K, Dennis Joe, Michailidou Kyriaki et al. 2016. PLoS ONE -
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
Liu J, Loncar I, Collée JM, Bolla MK, Dennis J, Michailidou K, Wang Q, Andrulis IL, Barile M, Beckmann MW, Behrens S, Benitez J, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brennan P, Brenner H, Broeks A et al. (incl. Mannermaa Arto, Kosma Veli-Matti). 2016. Scientific reports -
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
Seibold Petra, Schmezer Peter, Behrens Sabine, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Flesch-Janys Dieter, Nevanlinna Heli, Fagerholm Rainer, Aittomäki Kristiina, Blomqvist Carl, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Lambrechts Diether, Wildiers Hans, Kristensen Vessela, Alnæs Grethe Grenaker et al. 2015. Bmc cancer -
Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
Sobral-Leite Marcelo, Wesseling Jelle, Smit Vincent THBM, Nevanlinna Heli, van Miltenburg Martine H, Sanders Joyce, Hofland Ingrid, Blows Fiona M, Coulson Penny, Patrycja Gazinska, Schellens Jan HM, Fagerholm Rainer, Heikkilä Päivi, Aittomäki Kristiina, Blomqvist Carl, Provenzano Elena, Ali Hamid Raza, Figueroa Jonine, Sherman Mark, Lissowska Jolanta et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Bmc medicine -
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy
Lei Jieping, Rudolph Anja, Moysich Kirsten B, Rafiq Sajjad, Behrens Sabine, Goode Ellen L, Pharoah Paul PD, Seibold Petra, Fasching Peter A, Andrulis Irene L, Kristensen Vessela N, Couch Fergus J, Hamann Ute, Hooning Maartje J, Nevanlinna Heli, Eilber Ursula, Bolla Manjeet K, Dennis Joe, Wang Qin, Lindblom Annika et al (incl. Mannermaa Arto, Kosma Veli-Matti, Hartikainen Jaana M, Kataja Vesa). 2015. Breast cancer research -
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers
Meeks Huong D, Song Honglin, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Barrowdale Daniel, Frost Debra, McGuffog Lesley, Ellis Steve, Feng Bingjian, Buys Saundra S, Hopper John L, Southey Melissa C, Tesoriero Andrea, James Paul A, Bruinsma Fiona, Campbell Ian G, Broeks Annegien, Schmidt Marjanka K et al. 2015. Journal of the national cancer institute -
Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
Candido Dos Reis FJ, Lynn S, Ali HR, Eccles D, Hanby A, Provenzano E, Caldas C, Howat WJ, McDuffus LA, Liu B, Daley F, Coulson P, Vyas RJ, Harris LM, Owens JM, Carton AF, McQuillan JP, Paterson AM, Hirji Z, Christie SK et al.. 2015. EBioMedicine -
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk
Guo X, Long J, Zeng C, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Milne RL, Shu XO, Cai Q, Beesley J, Kar SP, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Blot W, Bogdanova N et al.. 2015. Cancer epidemiology biomarkers and prevention -
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Orr Nick, Dudbridge Frank, Dryden Nicola, Maguire Sarah, Novo Daniela, Perrakis Eleni, Johnson Nichola, Ghoussaini Maya, Hopper John L, Southey Melissa C, Apicella Carmel, Stone Jennifer, Schmidt Marjanka K, Broeks Annegien, Van't Veer Laura J, Hogervorst Frans B, Fasching Peter A, Haeberle Lothar, Ekici Arif B, Beckmann Matthias W et al (incl. Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen). 2015. Human molecular genetics -
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1
Glubb Dylan M, Maranian Mel J, Michailidou Kyriaki, Pooley Karen A, Meyer Kerstin B, Kar Siddhartha, Carlebur Saskia, O'Reilly Martin, Betts Joshua A, Hillman Kristine M, Kaufmann Susanne, Beesley Jonathan, Canisius Sander, Hopper John L, Southey Melissa C, Tsimiklis Helen, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Hogervorst Frans B et al (incl. Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti KosmaI). 2015. American journal of human genetics -
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium
Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, Benitez J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Fasching PA, Haeberle L, Peto J, Dos-Santos-Silva I, Sawyer EJ et al.. 2015. Human genetics -
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Michailidou Kyriaki, Beesley Jonathan, Lindstrom Sara, Canisius Sander, Dennis Joe, Lush Michael J, Maranian Mel J, Bolla Manjeet K, Wang Qin, Shah Mitul, Perkins Barbara J, Czene Kamila, Eriksson Mikael, Darabi Hatef, Brand Judith S, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Nielsen Sune F, Rahman Nazneen et al (incl. Arto Mannermaa, Jaana Hartikainen, Veli-Matti Kosma, Vesa Kataja). 2015. Nature genetics -
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization
Zhang Ben, Shu Xiao-Ou, Delahanty Ryan J, Zeng Chenjie, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Wen Wanqing, Long Jirong, Li Chun, Dunning Alison M, Chang-Claude Jenny, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G et al. (incl. Mannermaa A, Kataja V, Kosma V-M, Hartikainen JM). 2015. Journal of the national cancer institute -
Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
Sung Hyuna, Garcia-Closas Montserrat, Chang-Claude Jenny, Blows Fiona M, Ali H Raza, Figueroa Jonine, Nevanlinna Heli, Fagerholm Rainer, Heikkilä Päivi, Blomqvist Carl, Giles Graham G, Milne Roger L, Southey Melissa C, McLean Catriona, Mannermaa Arto, Kosma Veli-Matti, Kataja Vesa, Sironen Reijo, Couch Fergus J, Olson Janet E et al. 2015. British journal of cancer -
Identification of Novel Genetic Markers of Breast Cancer Survival
Guo Qi, Schmidt Marjanka K, Kraft Peter, Canisius Sander, Chen Constance, Khan Sofia, Tyrer Jonathan, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Lush Michael, Kar Siddhartha, Beesley Jonathan, Dunning Alison M, Shah Mitul, Czene Kamila, Darabi Hatef, Eriksson Mikael, Lambrechts Diether et al. (incl. Mannermaa Arto). 2015. Journal of the national cancer institute -
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
Kabisch Maria, Bermejo Justo Lorenzo, Dünnebier Thomas, Ying Shibo, Michailidou Kyriaki, Bolla Manjeet K, Wang Qin, Dennis Joe, Shah Mitul, Perkins Barbara J, Czene Kamila, Darabi Hatef, Eriksson Mikael, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Lambrechts Diether, Neven Patrick, Peeters Stephanie et al (incl.. 2015. Carcinogenesis -
KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes
Hartikainen Jaana M, Tengström Maria, Winqvist Robert, Jukkola-Vuorinen Arja, Pylkäs Katri, Kosma Veli-Matti, Soini Ylermi, Mannermaa Arto. 2015. Clinical cancer research -
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Day Felix R, Ruth Katherine S, Thompson Deborah J, Lunetta Kathryn L, Pervjakova Natalia, Chasman Daniel I, Stolk Lisette, Finucane Hilary K, Sulem Patrick, Bulik-Sullivan Brendan, Esko Tõnu, Johnson Andrew D, Elks Cathy E, Franceschini Nora, He Chunyan, Altmaier Elisabeth, Brody Jennifer A, Franke Lude L, Huffman Jennifer E, Keller Margaux F et al.. 2015. Nature genetics -
Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival
Pelkonen Mikko, Luostari Kaisa, Tengström Maria, Ahonen Hermanni, Berdel Bozena, Kataja Vesa, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto. 2015. Bmc cancer -
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
Hatef Darabi, Karen McCue, Jonathan Beesley, Kyriaki Michailidou, Silje Nord,Siddhartha Kar, Keith Humphreys, Deborah Thompson, Maya Ghoussaini, Manjeet K. Bolla, Joe Dennis, Qin Wang, Sander Canisius, Christopher G. Scott, Carmel Apicella, John L. Hopper, Melissa C. Southey, Jennifer Stone, Annegien Broeks, Marjanka K. Schmidt et al (incl. Veli-Matti Kosma, Arto Mannermaa). 2015. American journal of human genetics -
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Mavaddat Nasim, Pharoah Paul DP, Michailidou Kyriaki, Tyrer Jonathan, Brook Mark N, Bolla Manjeet K, Wang Qin, Dennis Joe, Dunning Alison M, Shah Mitul, Luben Robert, Brown Judith, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Czene Kamila, Darabi Hatef, Eriksson Mikael, Peto Julian et al (incl. Arto Mannermaa). 2015. Journal of the national cancer institute -
SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma
Jouppila-Mättö Anna, Mannermaa Arto, Sironen Reijo, Kosma Veli-Matti, Soini Ylermi, Pukkila Matti. 2015. Histology and histopathology -
SNP-SNP interaction analysis of NF-kappaB signaling pathway on breast cancer survival
Jamshidi Maral, Fagerholm Rainer, Khan Sofia, Aittomäki Kristiina, Czene Kamila, Darabi Hatef, Li Jingmei, Andrulis Irene L, Chang-Claude Jenny, Devilee Peter, Fasching Peter A, Michailidou Kyriaki, Bolla Manjeet K, Dennis Joe, Wang Qin, Guo Qi, Rhenius Valerie, Cornelissen Sten, Rudolph Anja, Knight Julia A et al. 2015. Oncotarget -
The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients
Fagerholm Rainer, Schmidt Marjanka K, Khan Sofia, Rafiq Sajjad, Tapper William, Aittomäki Kristiina, Greco Dario, Heikkinen Tuomas, Muranen Taru A, Fasching Peter A, Janni Wolfgang, Weinshilboum Richard, Loehberg Christian R, Hopper John L, Southey Melissa C, Keeman Renske, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kataja Vesa et al. 2015. Oncotarget -
Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function
Virtakoivu Reetta, Mai Anja, Mattila Elina, De Franceschi Nicola, Imanishi Susumu Y., Corthals Garry, Kaukonen Riina, Saari Markku, Cheng Fang, Torvaldson Elin, Kosma Veli-Matti, Mannermaa Arto, Muharram Ghaffar, Gilles Christine, Eriksson John, Soini Ylermi, Lorens James B., Ivaska Johanna. 2015. Cancer research -
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Li Jingmei, Lindström Linda S, Foo Jia N, Rafiq Sajjad, Schmidt Marjanka K, Pharoah Paul DP, Michailidou Kyriaki, Dennis Joe, Bolla Manjeet K, Wang Qin, Van 't Veer Laura J, Cornelissen Sten, Rutgers Emiel, Southey Melissa C, Apicella Carmen, Dite Gillian S, Hopper John S, Fasching Peter A, Haeberle Lothar, Ekici Arif B et al. 2014. Nature communications -
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium
Milne RL, Herranz J, Michailidou K, Dennis J, Tyrer JP, Zamora MP, Arias-Perez JI, González-Neira A, Pita G, Alonso MR, Wang Q, Bolla MK, Czene K, Eriksson M, Humphreys K, Darabi H,..., Mannermaa A, Kataja V, Kosma VM, Hartikainen J, et al.. 2014. Human molecular genetics -
Breast-cancer risk in families with mutations in PALB2
Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Co. 2014. The new england journal of medicine -
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium
Milne RL, Burwinkel B, Michailidou K, Arias-Perez JI, Zamora MP, Menéndez-Rodríguez P, Hardisson D, Mendiola M, González-Neira A, Pita G, Alonso MR, Dennis J, Wang Q, Bolla MK, Swerdlow A, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Human molecular genetics -
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. Nature communications -
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Mannermaa A, Kataja V, Kosma V-M, Hartikainen J, Easton DF, Pharoah PDP, Arias-Perez JI, Zamora P, Benitez J, Milne RL et.al. 2014. British journal of cancer -
Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer
Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. 2014. Clinical genetics -
Genetic predisposition to in situ and invasive lobular carcinoma of the breast
Sawyer Elinor, Roylance Rebecca, Petridis Christos, Brook Mark N, Nowinski Salpie, Papouli Efterpi, Fletcher Olivia, Pinder Sarah, Hanby Andrew, Kohut Kelly, Gorman Patricia, Caneppele Michele, Peto Julian, dos Santos Silva Isabel, Johnson Nichola, Swann Ruth, Dwek Miriam, Perkins Katherine-Anne, Gillett Cheryl, Houlston Richard et al (incl. Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M,). 2014. PLoS genetics -
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Johnson Nichola, Dudbridge Frank, Orr Nick, Gibson Lorna, Jones Michael E, Schoemaker Minouk J, Folkerd Elizabeth J, Haynes Ben P, Hopper John L, Southey Melissa C, Dite Gillian S, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Van T Veer Laura J, Atsma Femke et al. 2014. Breast cancer research and treatment -
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, ...,Hartikainen JM, Kosma VM, Kataja V, et al.. 2014. Human molecular genetics -
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple negative breast cancer
Purrington Kristen S, Slager Susan, Eccles Diana, Yannoukakos Drakoulis, Fasching Peter A, Miron Penelope, Carpenter Jane, Chang-Claude Jenny, Martin Nicholas G, Montgomery Grant W, Kristensen Vessela, Anton-Culver Hoda, Goodfellow Paul, Tapper William J, Rafiq Sajjad, Gerty Susan M, Durcan Lorraine, Konstantopoulou Irene, Fostira Florentia, Vratimos Athanassios et.al. (including Kosma Veli-Matti, Mannermaa Arto). 2014. Carcinogenesis -
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Auvinen Päivi, Rilla Kirsi, Tumelius Ritva, Tammi Markku, Sironen Reijo, Soini Ylermi, Kosma Veli-Matti, Mannermaa Arto, Viikari Jukka, Tammi Raija. 2014. Breast cancer research and treatment -
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, Apicella C, Southey MC, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Th Rutgers EJ, Muir K, Lophatananon A, Stewart-Brown S, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, kConFab Investigators; Australian Ovarian Cancer Study Group, et al.. 2014. Human molecular genetics -
Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions
Schoeps Anja, Rudolph Anja, Seibold Petra, Dunning Alison M, Milne Roger L, Bojesen Stig E, Swerdlow Anthony, Andrulis Irene, Brenner Hermann, Behrens Sabine, Orr Nicholas, Jones Michael, Ashworth Alan, Li Jingmei, Cramp Helen, Connley Dan, Czene Kamila, Darabi Hatef, Chanock Stephen J, Lissowska Jolanta et al (incl Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana M, Mannermaa Arto). 2014. Genetic epidemiology -
Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Rudolph A, Milne RL, Truong T, Knight JA, Seibold P, Flesch-Janys D, Behrens S, Eilber U, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, ..., Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2014. International journal of cancer -
MicroRNA Related Polymorphisms and Breast Cancer Risk
Khan Sofia, Greco Dari, Michailidou Kyriaki, Milne Roger L, Muranen Taru A, Heikkinen Tuomas, Aaltonen Kirsimari, Dennis Joe, Bolla Manjeet K, Liu Jianjun, Hall Per, Irwanto Astrid, Humphreys Keith, Li Jingmei, Czene Kamila, Chang-Claude Jenny, Hein Rebecca, Rudolp Anja, Seibold Petra, Flesch-Janys Dieter et at (including Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Mannermaa Arto). 2014. PLoS ONE -
MnSOD rs4880 and XPD rs13181 polymorphisms predict the survival of breast cancer patients treated with adjuvant tamoxifen
Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Soini Ylermi, Hirvonen Ari, Kataja Vesa. 2014. Acta oncologica -
Overexpression of MicroRNA-200c Predicts Poor Outcome in Patients with PR-Negative Breast Cancer
Tuomarila M, Luostari K, Soini Y, Kataja V, Kosma VM, Mannermaa A. 2014. PLoS ONE -
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Perry John RB, Day Felix, Elks Cathy E, Sulem Patrick, Thompson Deborah J, Ferreira Teresa, He Chunyan, Chasman Daniel I, Esko Tõnu, Thorleifsson Gudmar, Albrecht Eva, Ang Wei Q, Corre Tanguy, Cousminer Diana L, Feenstra Bjarke, Franceschini Nora, Ganna Andrea, Johnson Andrew D, Kjellqvist Sanela, Lunetta Kathryn L et al. 2014. Nature -
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
Spurdle Amanda B, Couch Fergus J, Parsons Michael T, McGuffog Lesley, Barrowdale Daniel, Bolla Manjeet K, Wang Qin, Healey Sue, Schmutzler Rita Katharina, Wappenschmidt Barbara, Rhiem Kerstin, Hahnen Eric, Engel Christoph, Meindl Alfons, Ditsch Nina, Norbert Arnold, Plendl Hansjoerg, Niede et al. (incl. Hartikainen Jaana)racher Dieter, Sutter Christian, Wang-Gohrke Shan,. 2014. Breast cancer research -
Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer
Luostari Kaisa, Hartikainen Jaana M, Tengström Maria, Palvimo Jorma J, Kataja Vesa, Mannermaa Arto, Kosma Veli-Matti. 2014. PLoS ONE -
XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer
Tengström Maria, Mannermaa Arto, Kosma Veli-Matti, Hirvonen Ari, Kataja Vesa. 2014. Anticancer research -
γ -Secretase Components as Predictors of Breast Cancer Outcome
Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. 2013. PLoS ONE -
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication
Hein R, Flesch-Janys D, Dahmen N, Beckmann L, Lindström S, Schoof N, Czene K, Mittelstraß K, Illig T, Seibold P, Behrens S, Humphreys K, Li J, Liu J, Olson et al. 2013. Breast cancer research and treatment -
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
Nickels S, Truong T, Hein R, Stevens K, Buck K, Behrens S, Eilber U, Schmidt M, Häberle L, Vrieling A, Gaudet M, Figueroa J, Schoof N, Spurdle AB, Rudolph A, Fasching PA, Hopper JL, Makalic E, Schmidt DF, Southey MC, Beckmann MW, Ekici AB, Fletcher O, Gibson L, Silva Idos S, Peto J, Humphreys MK, Wang J, Cordina-Duverger E, Menegaux F, Nordestgaard BG, Bojesen SE, Lanng C, Anton-Culver H, Ziogas A, Bernstein L, Clarke CA, Brenner H, Müller H, Arndt V, Stegmaier C, Brauch H, Brüning T, Harth V; G. 2013. PLoS genetics -
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1
Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, et al.. 2013. American journal of human genetics -
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E et.al.. 2013. American journal of human genetics -
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, et. al. 2013. Nature genetics -
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk
Gaudet MM, Kuchenbaecker KB, Vijai J, Klein RJ, Kirchhoff T, McGuffog L, Barrowdale D, Dunning AM, Lee A, Dennis J, Healey S, Dicks E, Soucy P, Sinilnikova OM, Pankratz VS, Wang X, Eldridge RC, Tessier DC, Vincent D, Bacot F, Hogervorst FB, Peock S, Stoppa-Lyonnet D; KConFab Investigators, Peterlongo P, Schmutzler RK, Nathanson KL, Piedmonte M, Singer CF, Thomassen M; Ontario Cancer Genetics Network, Hansen Tv, Neuhausen SL, Blanco I, Greene MH, Garber J, Weitzel JN, Andrulis IL, Goldgar DE, D'A. 2013. PLoS genetics -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A et. al. 2013. Nature genetics -
Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer
Tuhkanen H, Hartikainen JM, Soini Y, Velasco G, Sironen R, Nykopp TK, Kataja V, Eskelinen M, Kosma VM, Mannermaa A.. 2013. International journal of cancer -
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz et al. 2013. Nature genetics -
The UGT1A6_19_GG genotype is a breast cancer risk factor
Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V, Pesch B, Brüning T, Baisch C, Hartikainen JM, Mannermaa A, Kosma VM, Kataja V, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Fasching PA, Beckmann M, Ekici AB, Hein A, Hall P, Li J, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Hamann U, Ko YD, Brauch H. & al.. 2013. Frontiers in genetics -
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI et.al.. 2012. Human mutation -
19p13.1 Is a Triple-Negative-Specific Breast Cancer Susceptibility Locus
Stevens Kristen N, Fredericksen Zachary, Vachon Celine M, Wang Xianshu, Margolin Sara, Lindblom Annika, Nevanlinna Heli, Greco Dario, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Vrieling Alina, Flesch-Janys Dieter, Sinn Hans-Peter, Wang-Gohrke Shan, Nickels Stefan, Brauch Hiltrud, Ko Yon-Dschun, Fischer Hans-Peter, Schmutzler Rita K. 2012. Cancer research -
9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
Warren H, Dudbridge F, Fletcher O, Orr N, Johnson N, Hopper JL, Apicella C, Southey MC, Mahmoodi M, Schmidt MK, Broeks A, Cornelissen S, Braaf LM, Muir KR, Lophatananon A, Chaiwerawattana A, Wiangnon S, Fasching PA, Beckmann MW, Ekici AB et al. 2012. Cancer epidemiology biomarkers and prevention -
Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Kirchhoff T, Gaudet MM, Antoniou AC, McGuffog L, Humphreys MK, Dunning AM, Bojesen SE, Nordestgaard BG, Flyger H, Kang D, Yoo KY, Noh DY, Ahn SH, Dork T, Schürmann P, Karstens JH, Hillemanns P, Couch FJ, Olson J, Vachon C, et.al.. 2012. PLoS ONE -
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions
Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R.. 2012. Science translational medicine -
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer
Weischer M, Nordestgaard BG, Pharoah P, Bolla MK, Nevanlinna H, van't Veer LJ, Garcia-Closas M, Jopper JL, Hall P, Andrulis IL, Devilee P, Fasching PA, Anton-Culver H, Lambrechts D, Hooning M, Cox A, Giles GG, Burwinkel B, Lindblom A, Couch FJ et.al.. 2012. Journal of clinical oncology -
Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association consortium (BCAC)
Hein R, Maranian M, Hopper J L, Kapuscinski M K, Southey M C, Park D J, Schmidt M K, Broeks A, Hogervorst F B L, Bueno-de-Mesquit H B, Muir K R, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching P A, Hein A, Ekici A B, Beckmann M W, Fletcher O, Johnson N, et.al.. 2012. PLoS ONE -
Genetic Polymorphisms and Protein Expression of NRF2 and Sulfiredoxin Predict Survival Outcomes in Breast Cancer
Hartikainen JM,Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y.. 2012. Cancer research -
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Drive K, Johnson N, Orr N, Dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, et al. 2012. Nature genetics -
Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer.
Berdel B, Nieminen K, Soini Y, Tengström M, Malinen M, Kosma VM, Palvimo J, Mannermaa A. 2012. Bmc cancer -
Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer
Auvinen P, Tammi R, Kosma VM, Sironen R, Soini Y, Mannermaa A, Tumelius R, Uljas E, Tammi M. 2012. International journal of cancer -
PREDICT Plus: Development and validation of a prognostic model for early breast cancer that includes HER2
Wishart GC, Bajdik CD, Dicks E, Provenzano E, Schmidt MK, Sherman M, Greenberg DC,. Green AR, Gelmon KA, Kosma V-M, Olson JE, Beckmann MW, Winqvist R, Cross SS, Severi G, Huntsman D, Pylkäs K, Ellis I, Nielsen TO, Giles G, et.al.. 2012. British journal of cancer -
Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors
Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Molecular and cellular endocrinology -
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?
Tengström M, Mannermaa A, Kosma V-M, Hirvonen A, Kataja V. 2012. Bmc cancer -
The role of genetic breast cancer susceptibility variants as prognostic factors
Fasching PA, Pharoah PD, Cox A, Nevanlinna H, Bojesen SE, Karn T, Broeks A, Van Leeuwen FE, Van't Veer LJ, Udo R, Dunning AM, Greco D, Aittomäki K, Blomqvist C, Shah M, Nordestgaard BG, Flyger H, Hopper JL, Southey MC, Apicella C, et.al.. 2012. Human molecular genetics -
7q21-rs6964587 and breast cancer risk: an extended case¿control study by the Breast Cancer Association Consortium
Milne Roger L, Lorenzo-Bermejo Justo, Burwinkel Barbara, Malats Nuria, Arias Jose Ignasio, Zamora Pilar M, Benitéz Javier, humphreys Manjeet K, Garciá-Closas Montserrat, Chanock Stephen J, Lissowska Jolanta, Sherman Mark E, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Nevanlinna Heli, Heikkinen Tuomas, Aittomäki Kristiina Blomqvist Carl, Anto-Culver Hoda, et al.. 2011. Journal of medical genetics -
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, Wang X, Ademuyiwa F, Ahmed S, Ambrosone CB, Baglietto L, Balleine R, Bandera EV, Beckmann MW, Berg CD, Bernstein L, Blomqvist C, Blot WJ, Brauch H, Buring JE, Carey LA, Carpenter JE, Chang-Claude J, Chanock SJ, Chasman DI, Clarke CL, Cox A, Cross SS, Deming SL, Diasio RB, Dimopoulos AM, Driver WR, Dünnebier T, Durcan L, Eccles D, Edlund CK, Ekici AB, Fasching PA, Feigelson HS, Flesch-Janys D, Fostira F, Försti A, Fountzilas G, Ger. 2011. Nature genetics -
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Yang Xiaohong R, Chang-Claude Jenny, Goode Ellen L, Couch Fergus J, Nevanlinna Heli, Milne Roger L, Gaudet Mia, Schmidt Marjanka K, Broeks Annegien, Cox Angela, Fasching Peter A, Hein Rebecca, Spurdle Amanda B, Blows Fiona, Driver Kristy, Flesch-Janys Dieter, Heinz Judith, Sinn Peter, Vrieling Alina, Heikkinen Tuomas et al. 2011. Journal of the national cancer institute -
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
Figueroa JD, Garcia-Closas M, Humphreys M, Platte R, Hopper JL, Southey MC, Apicella C, Hammet F, Schmidt MK, Broeks A, Tollenaar RA, Van't Veer LJ, Fasching PA, Beckmann MW, Ekici AB, Strick R, Peto J, Dos Santos Silva I, Fletcher O, Johnson N, Sawyer E, Tomlinson I, Kerin M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Bojesen S, Flyger H, Nordestgaard BG, Benítez J, Milne RL, Ignacio Arias J, Zamora MP, Brenner H, Müller H, Arndt V, Rahman N, Turnbull C, Seal S, Renwick A, Brauch H, Justenhov. 2011. Human molecular genetics -
Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H; GENICA consortium, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland R, Ekici AB, Tapper WJ, Gerty SM, Durcan L, Graham N, Hein R, Nickels S, Flesch-Janys D, Heinz J, Sinn HP, Konstantopoulou I, Fostira F, Pectasides D, Dimopoulos AM, Fountzilas G, Clarke CL, Balleine R, Olson JE, Fredericksen Z, Diasio RB, Patha. 2011. Cancer research -
Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer.
Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Pérez JI, Benítez J, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JC, Huang CS, Hou MF, Nordestgaard BG, Bojesen SE, Lanng C, Alnæs GG, Kristensen V, Børrensen-Dale AL, Hopper JL, Dite GS, Apicella C, Southey MC, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Sangrajrang S, Gaborieau V, Brennan P, McKay. 2011. Cancer epidemiology biomarkers and prevention -
Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.
Stevens KN, Garcia-Closas M, Fredericksen Z, Kosel M, Pankratz VS, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Tollenaar RA, Fasching PA, Beckmann MW, Hein A, Ekici AB, Johnson N, Peto J, Dos Santos Silva I, Gibson L, Sawyer E, Tomlinson I, Kerin MJ, Chanock S, Lissowska J, Hunter DJ, Hoover RN, Thomas GD, Milne RL, Pérez JA, González-Neira A, Benítez J, Burwinkel B, Meindl A, Schmutzler RK, Bartrar CR, Hamann U, Ko YD, Brüning T, Chang-Claude J, Hein R, Wan. 2011. British journal of cancer -
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Vuorela M, Pylkäs K, Hartikainen JM, Sundfeldt K, Lindblom A, von Wachenfeldt Wäppling A, Haanpää M, Puistola U, Rosengren A, Anttila M, Kosma VM, Mannermaa A, Winqvist R.. 2011. Breast cancer research and treatment -
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Broeks, Annegien; Schmidt, Marjanka K; Sherman, Mark E; Couch, Fergus J; Hopper, John L; Dite, Gillian S; Apicella, Carmen; Smith, Letitia D; Hammet, Fleur; Southey, Melissa C; Van't Veer, Laura J; de Groot, Renate; Smit, Vincent T. H. B. M; Fasching, Peter A; Beckmann, Matthias W; Jud, Sebastian; Ekici, Arif B; Hartmann, Arndt; Hein, Alexander; Schulz-Wendtland, Ruediger et al.. 2011. Human molecular genetics -
Transcription factors zeb1, twist and snai1 in breast carcinoma
Soini Ylermi, Tuhkanen Hanna, Sironen Reijo, Virtanen Ismo, Kataja Vesa, Auvinen Päivi, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer -
Transcription of factor snail1 expression and poor survival in pharyngeal squamous cell carcinoma
Jouppila-Mättö A, Tuhkanen H, Soini Y, Pukkila M, Närkiö-Mäkelä M, Sironen R, Virtanen I, Mannermaa A, Kosma V-M. 2011. Histology and histopathology -
Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression
Juoppila-Mättö Anna, Närkiö-Mäkelä Mervi, Soini Ylermi, Pukkila Matti, Sironen Reijo, Tuhkanen Hanna, Mannermaa Arto, Kosma Veli-Matti. 2011. Bmc cancer -
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival
Azzato EM, Tyrer J, Fasching PA, Beckmann MW, Ekici AB, Schulz-Wendtland R, Bojesen SE, Nordestgaard BG, Flyger H, Milne RL, et.al.. 2010. Journal of the national cancer institute -
Association of ESR1 gene tagging SNPs with breast cancer risk
Dunning AM, Healey CS, Baynes C, Maia A-T, Scollen S, Vega A, Rodrígues R, Barbosa-Morais N L, Ponder BAJ..., Mannermaa A, Kosma V-M, ...Pooley KA, Chenevix-Trench G. 2009. Human molecular genetics -
Beta-amyloid deposition in brains of subjects with diabetes
Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H, Soininen H. 2009. Neuropathology and applied neurobiology -
Combined risk effects of IDE and NEP gene variants on Alzheimer disease
Vepsäläinen S, Helisalmi S, Mannermaa A, Pirttilä T, Soininen H, Hiltunen M, Helisalmi S, Pirttilä T, Soininen H, Hiltunen M. 2009. Journal of neurology neurosurgery and psychiatry -
Five polymorphisms and breast cancer risk: results from the breast cancer association consortium
Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL..., Mannermaa A, Kataja V, Kosma V-M, Lindblom SM...et al. 2009. Cancer epidemiology biomarkers and prevention -
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Mannermaa A, Kosma V-M, Kataja V, ...Easton DF. 2009. Nature genetics -
Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
Tuhkanen H, Soini Y, Kosma V-M, Anttila M, Sironen R, Hämäläinen K, Kukkonen L, Virtanen I, Mannermaa A. 2009. Bmc cancer -
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042
Milne RL, Benítez J, Nevanlinna H, Heikkinen T..., Mannermaa A, Kataja V, Kosma V-M. 2009. Journal of the national cancer institute -
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
Garcia-Closas M, Hall P, Nevanlinna H ..., Mannermaa A, Uusitupa M, Eskelinen M, Tengström M, Kosma V-M, Kataja V, Chenevix-Trench G .... 2008. PLoS genetics -
NAD(P)H:quinone oxidoreductase 1 NQ01*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Fagerholm Rainer, Hofstetter Barbara, Tommiska Johanna, Aaltonen Kirsimari, Vrtel Radek, Syrjäkoski Kirsi, Kallioniemi Anne, Kilpivaara Outi, Mannermaa Arto, Kosma Veli-Matti, Uusitupa Matti, Eskelinen Matti, Kataja Vesa, Aittomäki Kristiina. 2008. Nature genetics -
Penetrance analysis of the PALB2 c.1592delT founder mutation
Erkko H, Dowty JG, Nikkilä J, Syrjäkoski K, Mannermaa A, Pylkäs K, Southey MC, Holli K, Kallioniemi A, Jukkola-Vuorinen A, Kataja Vesa, Kosma V-M, Xia B, Livingston DM, Wingvist R, Hopper JL. 2008. Clinical cancer research -
A BRCA2 mutation, 4088insA, in a Finnish breast and ovarian cancer family associated with favourable clinical course
Hartikainen JM, Mannermaa A, Heinonen S, Kosma V-M, Kataja V. 2007. Anticancer research -
A common coding variant in CASP8 is associated with breast cancer risk
Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MWR, Pooley KA..., Mannermaa A, Hartikainen J, Kataja V, Kosma V-M, ... Couch FJ .... 2007. Nature genetics -
A recurrent mutation in PALB2 in Finnish cancer families
Erkko Hannele, Bing Xia, Nikkilä Jenni, Schleutker Johanna, Syrjäkoski Kirsi, Mannermaa Arto, Kallioniemi Anne, Pylkäs Katri, Karppinen Sanna-Maria, Rapakko Katrin, Alexander Miron, Qing Sheng, Guilan Li, Mattila Henna, Daphene W. Bell. 2007. Nature -
Genome-wide association study identifies novel breast cancer susceptibility loci
Easton DF, Pooley KA, Dunning AM..., Mannermaa A, Kosma V-M, Kataja V, Hartikainen J. 2007. Nature -
Insulin-degrading enzyme is genetically associated wirh Alzheimer's disease in the finnish population
Vepsäläinen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi RE, Bertram L, Hiltunen M, Vepsäläinen S, Helisalmi S, Soininen H, Hiltunen M. 2007. Journal of medical genetics -
Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families
Hartikainen JM, Kataja V, Pirskanen M, Arffman A, Ristomaa U, Vahteristo P, Ryynänen M, Heinonen S, Kosma V-M, Mannermaa A. 2007. Clinical genetics -
Association of CYP46 intron 2 polymorphism in Finnish Alzheimer¿s disease samples and a global scale summary
Helisalmi S, Vepsäläinen S, Koivisto AM, Mannermaa A, Iivonen S, Hiltunen M, Kiviniemi V, Soininen H, Helisalmi S, Vepsäläinen S, Koivisto AM, Iivonen S, Hiltunen M, Soininen H. 2006. Journal of neurology neurosurgery and psychiatry -
Commonly studied single-nucleotide polymorphism and breast cancer: results from the breast cancer association consortium
The Breast Cancer Association Consortium, Mannermaa A, Kataja V, Kosma V-M. 2006. Journal of the national cancer institute -
Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas
Tuhkanen H, Anttila M, Kosma V-M, Heinonen S, Juhola M, Helisalmi S, Kataja V, Mannermaa A, Helisalmi S. 2006. International journal of cancer -
Refinement of the 22q12-q13 Breast Cancer-Associated Region:Evidence of TMPRSS6 as a Candidate in an Eastern Finnish Population
Hartikainen JM, Tuhkanen H, Kataja V, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2006. Clinical cancer research -
An autosome-wide scan for linkage disequilibrium-based association in sporadic breast cancer cases in Eastern Finland: three candidate regions found
Hartikainen JM, Tuhkanen H, Kataja V, Dunning AM, Antoniou A, Smith P, Arffman A, Pirskanen M, Easton DF, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A. 2005. Cancer epidemiology biomarkers and prevention -
Estrogen receptor beta gene variants are associated with increased risk of Alzheimer¿s disease in women
Pirskanen M, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Helisalmi S, Soininen H. 2005. European journal of human genetics -
Genetic analysis on BDNF and TrkB gene polymorphisms in Alzheimer's disease
Vepsäläinen S, Castren E, Helisalmi S, Iivonen S, Mannermaa A, Lehtovirta M, Hänninen T, Soininen H, Hiltunen M, Vepsäläinen S, Helisalmi S, Iivonen S, Soininen H, Hiltunen M. 2005. Journal of neurology -
CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies
The CHEK2 Breast Cancer Case-Control Consortium, Kataja V. 2004. American journal of human genetics -
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer
Dunning AM, Ellis PD, McBride S, Kirschenlohr HL, Healey CS, Kemp PR, Luben RN, Chang-Claude J, Mannermaa A, Kataja V, Pharoah PDP, Easton DF, Ponder BAJ, Metcalfe JC. 2003. Cancer research -
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H. 2002. Annals of internal medicine -
Fibrinogen and factor VII promoter polymorphism in women with preeclampsia
Laasanen J, Hiltunen M, Punnonen K, Mannermaa A, Heinonen S. 2002. Obstetrics and gynecology -
Interleukin 1 alpha gene polymorphism as a suscetibility factor in Alzheimer¿s disease and its influence on the extend of histopathological hallmark lesions of Alzheimer¿s sisease
Pirskanen M, Hiltunen M, Mannermaa A, Iivonen S, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H, Alafuzoff I. 2002. Dementia and geriatric cognitive disorders -
Lack of association between C-850T polymorphism of the gene encoding tumor necrosis factor-alfa and polycystic ovary syndrome
Korhonen S, Romppanen E-L, Hiltunen M, Mannermaa A, Punnonen K, Hippeläinen M, Heinonen S. 2002. Gynecological endocrinology -
Midlife income, occupation, APOE status, and dementia
Anttila T, Helkala E-L, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A. 2002. Neurology -
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson¿s disease in Finland
Autere JM, Hiltunen MJ, Mannermaa A, Jäkälä PA, Hartikainen PH, Majamaa K, Alafuzoff I, Soininen HS. 2002. European journal of neurology -
Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alfa gene polymorphisms in Finnish women with obstetric cholestasis
Eloranta M-L, Heiskanen JTM, Hiltunen MJ, Mannermaa AJ, Punnonen KRA, Heinonen ST. 2002. European journal of obstetrics and gynecology and reproductive biology -
Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia
Laasanen J, Heinonen S, Hiltunen M, Mannermaa A, Laakso M. 2002. Early human development -
Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia
Heiskanen J, Romppanen E-L, Hiltunen M, Iivonen S, Mannermaa A, Punnonen K, Heinonen S. 2002. Journal of assisted reproduction and genetics -
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer¿s disease
Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puoliväli J, Salminen A, Helisalmi S, Soininen H. 2002. Neuroscience -
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia
Laasanen J, Romppanen E-L, Hiltunen M, Helisalmi S, Mannermaa A, Punnonen K, Heinonen S. 2002. European journal of human genetics -
An association between a subset of Finnish late-onset Alzheimer¿s disease and alpha2-macroglobulin
Pirskanen M, Alafuzoff I, Hiltunen M, Mannermaa A, Helisalmi S, Lehtovirta M, Koivisto AM, Laakso M, Soininen H. 2001. Neurogenetics -
Antenatal gene tests in low-risk pregnancies: molecular screening for aspartylglucosaminuria (AGU) and infantile neuronal ceroid lipofuscinosis (INCL) in Finland
Kallinen J, Heinonen S, Palotie A, Mannermaa A, Ryynanen M. 2001. Prenatal diagnosis -
Antenatal genetic screening for congenital nephrosis
Kallinen J, Heinonen S, Ryynänen M, Pulkkinen L, Mannermaa A. 2001. Prenatal diagnosis -
Apolipoprotein E alleles in women with polycystic ovary syndrome
Heinonen S, Korhonen S, Hippeläinen M, Hiltunen M, Mannermaa A, Saarikoski S. 2001. Fertility and sterility -
Apolipoprotein E alleles in women with pre-eclampsia
Makkonen N, Heinonen S, Hiltunen M, Helisalmi S, Mannermaa A, Kirkinen P. 2001. Journal of clinical pathology -
Genome-wide linkage disequilibrium mapping of late-onset Alzheimr¿s disease in Finland
Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 2001. Neurology -
Increased risk of sensorineural hearing loss and migraine in patients with a rare mitochondrial DNA variant 4336A>G in tRNA
Finnilä S, Autere J, Lehtovirta M, Hartikainen P, Mannermaa A, Soininen H, Majamaa K. 2001. Journal of medical genetics -
Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia
Heiskanen JT, Pirskanen MM, Hiltunen MJ, Mannermaa AJ, Punnonen KR, Heinonen ST. 2001. American journal of obstetrics and gynecology -
Maternal susceptibility locus for obstetric cholestasis maps to chromosone region 2p13 in finnish patients
Heinonen S, Eloranta M-L, Heiskanen J, Punnonen K, Helisalmi S, Mannermaa A, Hiltunen M. 2001. Scandinavian journal of gastroenterology -
Wide scope prenatal diagnosis at Kuopio University Hospital 1997-1998: integration of gene tests and fetal karyotyping
Kallinen J, Marin K, Heinonen S, Mannermaa A, Palotie A, Ryynänen M. 2001. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY -
Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy
Eloranta M-L, Heiskanen J, Hiltunen M, Helisalmi S, Mannermaa A, Heinonen S. 2000. Scandinavian journal of gastroenterology -
Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2 alfa in cutaneous melanoma
Karjalainen JM, Kellokoski JK, Mannermaa AJ, Kujala HE, Moisio KI, Mitchell PJ, Eskelinen MJ, Alhava EM, Kosma VM. 2000. British journal of cancer -
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer¿s disease family: an Alu core sequence-stimulated recombination?
Hiltunen M, Helisalmi S, Mannermaa A, Alafuzoff I, Koivisto AM, Lehtovirta M, Pirskanen M, Sulkava R, Verkkoniemi A, Soininen H. 2000. European journal of human genetics -
Is the presenilin-1 E318G missense mutation a risk factor for Alzheimer¿s disease?
Helisalmi S, Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Alafuzoff I, Ryynänen M, Soininen H. 2000. Neuroscience letters -
Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer: correlation to clinicopathological variables
Launonen V, Mannermaa A, Stenbäck F, Kosma V-M, Puistola U, Huusko P, Anttila M, Bloigu R, Saarikoski S, Kauppila A, Winqvist R. 2000. Cancer genetics and cytogenetics -
Prenatal diagnosis of fragile X syndrome and the risk of expansion of a premutation
Kallinen J, Heinonen S, Mannermaa A, Ryynänen M. 2000. Clinical genetics -
Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia
Alafuzoff I, Helisalmi S, Mannermaa A, Soininen H. 2000. Annals of the New York Academy of Sciences -
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide y is not associated with Alzheimer¿s disease or the link apolipoprotein E
Helisalmi S, Valve R, Karvonen MK, Hiltunen M, Pirskanen M, Mannermaa A, Koulu M, Pesonen U, Uusitupa M, Soininen H. 2000. Neuroscience letters -
Beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients
Alafuzoff I, Helisalmi S, Mannermaa A, Riekkinen P Sr, Soininen H. 1999. Stroke -
Feasibility and acceptance of screening for fragile X mutations in low-risk pregnancies
Ryynänen M, Heinonen S, Makkonen M, Kajanoja E, Mannermaa A, Kirkinen P. 1999. European journal of human genetics -
Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients
Hiltunen M, Mannermaa A, Koivisto AM, Lehtovirta M, Helisalmi S, Ryynänen M, Riekkinen P Sr, Soininen H. 1999. European journal of human genetics -
Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer¿s disease patients and control individuals
Helisalmi S, Hiltunen M, Valonen P, Mannermaa A, Koivisto AM, Lehtovirta M, Ryynänen M, Soininen H. 1999. Journal of neurology -
Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer¿s disease patients
Hiltunen M, Mannermaa A, Helisalmi S, Koivisto A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Neuroscience letters -
Fragiili X-oireyhtymän mutaatioiden seulonta alkuraskauden aikana - tulokset ja äitien mielipiteet geenitestistä
Ryynänen M, Heinonen S, Makkonen M, Mannermaa A, Kirkinen P. 1998. Duodecim -
Longitudinal SPECT study in Alzheimer`s disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen P Sr, Soininen H. 1998. Journal of neurology neurosurgery and psychiatry -
Fragile-X: Neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes
Jäkälä P, Hänninen T, Ryynänen M, Laakso M, Partanen K, Mannermaa A, Soininen H. 1997. Journal of clinical investigation -
Lack of association between presenilin-1 polymorphism, Alzheimer's disease and apolipoprotein E
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. ALZHEIMER'S RESEARCH -
No association between alfa1-antichymotrypsin polymorphism, apolipoprotein E and patients with late-onset Alzheimer`s disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1997. Neuroscience letters -
Apolipoprotein E polymorphism in patients with different neurodegenerative disorders
Helisalmi S, Linnaranta K, Lehtovirta M, Mannermaa A, Heinonen O, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters -
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Hartikainen P, Hänninen T, Ryynänen M, Riekkinen PJ Sr. 1996. Neurology -
Deletion in the FMR1 gene in a fragile-x male
Mannermaa A, Pulkkinen L, Kajanoja E, Ryynänen M, Saarikoski S. 1996. American journal of medical genetics. Part A -
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon4 allele
Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, Ryynänen M, Kuikka J, Hartikainen P, Riekkinen PJ Sr. 1996. Journal of neurology neurosurgery and psychiatry -
Screening for amyloid beta precursor protein codon 665, 670/671 and 717 mutations in Finnish patients with Alzheimer's disease
Helisalmi S, Mannermaa A, Lehtovirta M, Ryynänen M, Riekkinen P Sr, Soininen H. 1996. Neuroscience letters -
Spectral analysis of EEG in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta M, Partanen J, Könönen M, Soininen H, Helisalmi S, Mannermaa A, Ryynänen M, Hartikainen P, Riekkinen P Sr. 1996. Neurobiology of aging -
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein e4 allele
Soininen H, Kosunen O, Helisalmi S, Mannermaa A, Paljärvi L, Talasniemi S, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters -
Alzheimer pathology of patients carrying apolipoprotein E epsilon4 allele
Heinonen O, Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Sorvari H, Kosunen O, Paljärvi L, Ryynänen M, Riekkinen PJ Sr. 1995. Neurobiology of aging -
Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland
Lehtovirta M, Helisalmi S, Mannermaa A, Soininen H, Koivisto K, Ryynänen M, Riekkinen P Sr. 1995. Neuroscience letters -
Carrier diagnosis of the fragile X syndrome-A challenge in antenatal clinics
Ryynänen M, Kirkinen P, Mannermaa A, Saarikoski S. 1995. American journal of obstetrics and gynecology -
Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele
Soininen H, Partanen K, Pitkänen A, Hallikainen M, Hänninen T, Helisalmi S, Mannermaa A, Ryynänen M, Koivisto K, Riekkinen P Sr. 1995. Neurology -
Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients
Kosunen O, Talasniemi S, Lehtovirta M, Heinonen O, Helisalmi S, Mannermaa A, Paljärvi L, Ryynänen M, Riekkinen PJ Sr, Soininen H. 1995. Stroke -
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes
Lehtovirta M, Laakso MP, Soininen H, Helisalmi S, Mannermaa A, Helkala E-L, Partanen K, Ryynänen M, Vainio P, Hartikainen P, Riekkinen PJ Sr. 1995. Neuroscience