
Ville Paakinaho
Academy Research Fellow
Doctor of Philosophy (Ph.D.), Adjunct professor
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
[email protected] | +358 50 512 8721
I act as academy research fellow and research group leader in the Institute of Biomedicine at University of Eastern Finland. My research focuses on deciphering how nuclear protein interactions alter the regulation of genes in prostate cancer, and how these changes lead to the development of drug-resistant cancer. In addition to prostate cancer, I investigate the activity, interactions, and alteration of these proteins also in other disease states. More detailed description of my research can be found at our research group page (Paakinaho lab).
Research groups
Academic degrees and positions
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2021 Title of a Docent (in the field of molecular endocrinology) (equivalent of Adjunct professor), University of Eastern Finland
2014 PhD (medical biochemistry), University of Eastern Finland
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Current positions
2023 Assistant Professor (tenure track), Institute of Biomedicine, UEF
2021 Academy Research Fellow, Institute of Biomedicine, UEF
Past positions
2019, Special Volunteer, National Cancer Institute, NIH, USA
2018 – 2021, Postdoctoral Fellow (Academy of Finland), Institute of Biomedicine, UEF
2015 – 2017, Postdoctoral Fellow, National Cancer Institute, NIH, USA
2010 – 2014, Early Stage Researcher, Institute of Biomedicine, UEF
Teaching activities and positions of trust
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Current teaching activities
Since 2018
Course director: Genome-wide gene expression project (GEP), Master’s program in Biomedicine, University of Eastern Finland
Past teaching activities
2023-2024
Course organizer: Cancer Journal Club, Postgraduate studies, University of Eastern Finland
2014
Lecturer: Johdatus bioinformatiikkaan (JOBI), Health bioscience degree programme, University of Eastern Finland
Laboratory instructor: Advanced laboratory works in molecular biology (ALMB), Health bioscience degree programme, University of Eastern Finland
2013
Laboratory instructor: Molekyylibiologian laboratoriotyöt biokemisteille (BIK390), Bioscience degree programme, University of Eastern Finland
Laboratory instructor: Lääketieteellinen biokemia 2 (LBK2), Medical degree programme, University of Eastern Finland
2012
Laboratory instructor: Molekyylibiologian laboratoriotyöt biokemisteille (BIK390), Bioscience degree programme, University of Eastern Finland
2011
Laboratory instructor: Lääketieteellinen biokemia 2 (LBK2), Medical degree programme, University of Eastern Finland
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Since 2023
Member of the steering group, The Multidisciplinary Cancer Research community, University of Eastern Finland
Since 2022
Member of the executive committee, The Finnish Endocrine Society
Honours
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2022, Unto Uotila Award (Young Investigator Award), Finnish Endocrine Society, Finland
2019, The Endocrine Society Outstanding Abstract Award, Endocrine Society, United States
2017, The Fellows Award for Research Excellence (FARE), NIH, United States
2015, Young Researcher Award, UEF, Finland
Links
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Publication in Pubmed database
News (in Finnish): Steroidireseptorien tutkimuskeskus yhdistää nuoria huippututkijoita
News (in Finnish): Ville Paakinaholle Unto Uotila -palkinto
News (in Finnish): Ville Paakinaholle jaettiin Unto Uotila-palkinto Endopäivillä 2022
News: New insight into combatting drug-resistant prostate cancer
News: The glucocorticoid receptor is a double-edged sword in prostate cancer
Publications
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Androgen receptor-mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
Hiltunen, Johannes; Helminen, Laura; Aaltonen, Niina; Launonen, Kaisa-Mari; Laakso, Hanna; Malinen, Marjo; Niskanen, Einari A; Palvimo, Jorma J; Paakinaho, Ville. 2025. Genome research. [Epub ahead of print June 2, 2025]: 1-17 A1 Journal article (refereed), original research -
Matrix stiffness modulates androgen response genes and chromatin state in prostate cancer
Kaarijärvi, Roosa; Kaljunen, Heidi; Niemi, Onni; Räsänen, Merja; Paakinaho, Ville; Ketola, Kirsi. 2025. NAR cancer. 7: . zcaf010 A1 Journal article (refereed), original research -
SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells
Valima, Emma; Varis, Vera; Bureiko, Kseniia; Lempiäinen, Joanna K; Schroderus, Anna-Mari; Oksa, Laura; Lohi, Olli; Kinnunen, Tuure; Varjosalo, Markku; Niskanen, Einari A; Paakinaho, Ville; Palvimo, Jorma J. 2025. Oncogene. 44: 1259–1271 A1 Journal article (refereed), original research -
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
Van Dender, Céline; Timmermans, Steven; Paakinaho, Ville; Vanderhaeghen, Tineke; Vandewalle, Jolien; Claes, Maarten; Garcia, Bruno; Roman, Bart; De Waele, Jan; Croubels, Siska; De Bosscher, Karolien; Meuleman, Philip; Herpain, Antoine; Palvimo, Jorma J; Libert, Claude. 2024. Embo molecular medicine. 16: 2485-2515 A1 Journal article (refereed), original research -
Central role of SUMOylation in the regulation of chromatin interactions and transcriptional outputs of the androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Varis, Vera; Aaltonen, Niina; Niskanen, Einari A; Varjosalo, Markku; Paakinaho, Ville; Palvimo, Jorma J. 2024. Nucleic acids research. 52: 9519-9535 A1 Journal article (refereed), original research -
DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Kaarijärvi, Roosa; Kaljunen, Heidi; Nappi, Lucia; Fazli, Ladan; Kung, Sonia H. Y.; Hartikainen, Jaana M.; Paakinaho, Ville; Capra, Janne; Rilla, Kirsi; Malinen, Marjo; Mäkinen, Petri I.; Ylä-Herttuala, Seppo; Zoubeidi, Amina; Wang, Yuzhuo; Gleave, Martin E.; Hiltunen, Mikko; Ketola, Kirsi. 2024. Communications biology. 7: . 108 A1 Journal article (refereed), original research -
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
Huttunen, Jasmin; Aaltonen, Niina; Helminen, Laura; Rilla, Kirsi; Paakinaho, Ville. 2024. Cellular and molecular life sciences. 81: . 160 A1 Journal article (refereed), original research -
Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk
Hiltunen, Johannes; Helminen, Laura; Paakinaho, Ville. 2024. Frontiers in endocrinology. 15: . 1437179 A2 Review article, Literature review, Systematic review -
RNA sequencing analysis reveals distinct gene expression patterns in infrapatellar fat pads of patients with end-stage osteoarthritis or rheumatoid arthritis
Mustonen, Anne-Mari; Malinen, Marjo; Paakinaho, Ville; Lehenkari, Petri; Palosaari, Sanna; Kärjä, Vesa; Nieminen, Petteri. 2024. Biochimica et biophysica acta: molecular and cell biology of lipids. 2025; 1870: A1 Journal article (refereed), original research -
SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer
Leppänen, Noora; Kaljunen, Heidi; Takala, Eerika; Kaarijärvi, Roosa; Mäkinen, Petri I; Ylä-Herttuala, Seppo; Paatero, Ilkka; Paakinaho, Ville; Ketola, Kirsi. 2024. Nucleic acids research. 52: 5610-5623 A1 Journal article (refereed), original research