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Marja Hedman

Marja Hedman

Professor

Predictive factors for aortic dilatation and rupture -Translational clinical study

Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences

[email protected]

Information Publications

Prediction of aortic dilatation and rupture by means of modern 4D flow MRI technology, molecular biology methods and mathematical algorithms in preclinical models and in clinical study.

Research groups

Embodetect Study Group 01.01.2022 -
Modern methods in cardiac imaging (MOMESY)
Pain Neuromodulation Group 01.01.2022 -
Cardiovascular imaging and predictive markers 01.01.2022 -

Keywords

aortic aneurysm aortic dilatation aortic dissection artificial intelligence cardiothoracic surgery cardiovascular diseases computed tomography gene therapy myocardial perfusion imaging nuclear medicine translational research

Publications

66/66 items

Combining ascending aortic diameter and length and their growth rates improves the prediction of type A aortic dissection
Kotanen, Iida-Mari; Selander, Tuomas; Olsson, Christian; Franco-Cereceda, Anders; Marlevi, David; Saari, Petri; Korpela, Tarmo; Sillanmäki, Saara; Hedman, Marja, 2026, European journal of cardio-thoracic surgery, 68, 3, ezag110. A1 Journal article (refereed), original research
Growth patterns of ascending aortic aneurysms
Kotanen, Iida-Mari; Selander, Tuomas; Sillanmäki, Saara; Saari, Petri; Rasinkangas, Heta; Korpela, Tarmo; Husso, Annastiina; Hedman, Marja, 2026, Journal of cardiothoracic surgery, 21, 404. A1 Journal article (refereed), original research
Impact of Carina Width on Re‐Ablation Rate of Atrial Fibrillation After Primary Cryoballoon‐Ablation
Müller, Miriam; Hedman, Marja; Heikkilä, Marianne; Junttila, Juhani, 2026, Journal of cardiovascular electrophysiology, [First published: 30 June 2026], 1-9. A1 Journal article (refereed), original research
The effect of age and sex on T1, T2, and T2* relaxation time constants in cardiac MRI in healthy Finnish population
Liukkonen, Mimmi K; Jämsä, Miska; Hartikainen, Suvi; Husso, Minna; Hedman, Marja; Hietanen, Heikki; Ugander, Martin; Sillanmäki, Saara; Ylä-Herttuala, Elias, 2026, Acta radiologica open, 15, 1, 1-12. A1 Journal article (refereed), original research
Cardiometabolic disorders affect myocardial [18F]fluorodeoxyglucose uptake– impact on diagnostic PET/CT imaging
Hartikainen, Suvi; Vepsäläinen, Ville; Tompuri, Tuomo; Laitinen, Tiina M; Hedman, Marja; Laitinen, Tomi, 2025, Ejnmmi research, 15, 1, 80. A1 Journal article (refereed), original research
Nousevan aortan laajentuman kuvantaminen ja seuranta ESC 2024 suosituksen mukaan
Sillanmäki, Saara; Husso, Annastiina; Saari, Petri; Viitala, Iida; Hedman, Marja, 2025, Sydänääni, 36, 1, 36-41. D1 Article in a trade journal
Prevalence and risk factors of thoracic aortic dilatation detected incidentally in adjuvant radiotherapy planning CT scans in patients with breast cancer
Lattu, Aada; Kauhanen, Petteri; Mennander, Ari; Hedman, Marja; Laaksonen, Mona; Rinta-Kiikka, Irina; Skyttä, Tanja; Arponen, Otso, 2025, Scientific reports, 15, 1, 22883. A1 Journal article (refereed), original research
SKS Atlas ylilääkärikysely 2024 - muutoksen tuulia
Hedman, Marja, 2025, Sydänääni, 36, 3, 304-309. D1 Article in a trade journal
Secondary aortic intervention may not impair survival in patients treated with TEVAR for type B aortic dissection: A Finnish national registry study
Juhana, Toimela; Marja, Hedman; Tuomas, Selander; Annastiina, Husso, 2025, Scandinavian journal of surgery, 114, 3, 358-364. A1 Journal article (refereed), original research
Uudet sydänlihaksen fibroosia ja supistumista arvioivat magneettikuvausmenetelmät sydämen vajaatoiminnan diagnostiikassa
Iso-Mustajärvi, Saara; Ylä-Herttuala, Elias; Hedman, Marja; Sillanmäki, Saara, 2025, Sydänääni, 36, 3, 350-356. D1 Article in a trade journal
Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study
Martinez-Majander, Nicolas; Kutal, Shakar; Ylikotila, Pauli; Yesilot, Nilufer; Tulkki, Lauri; Zedde, Marialuisa; Sarkanen, Tomi; Junttola, Ulla; Nordanstig, Annika; Fromm, Annette; Ryliskiene, Kristina; Licenik, Radim; Ferdinand, Phillip; Jatuzis, Dalius; Kõrv, Liisa; Kõrv, Janika; Pezzini, Alessandro; Tuohinen, Suvi; Sinisalo, Juha; Lehto, Mika; Gerdts, Eva; Ryödi, Essi; Autere, Jaana; Hedman, Marja; Fonseca, Ana Catarina; Waje-Andreassen, Ulrike; von Sarnowski, Bettina; Redfors, Petra; Sairane, 2024, Journal of neurology neurosurgery and psychiatry, 96, 2, 114-121. A1 Journal article (refereed), original research
Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study
Putaala, Jukka; von Sarnowski, Bettina; Schminke, Ulf; Busch, Raila; Martinez‐Majander, Nicolas; Ylikotila, Pauli; Lautamäki, Riikka; Zedde, Marialuisa; Grimaldi, Teresa; Sarkanen, Tomi; Virtanen, Marko; Ryliskiene, Kristina; Zakarkaite, Diana; Tulkki, Lauri; Pirinen, Jani; Licenik, Radim; Ferdinand, Phillip; Oxley, Cheryl; Kõrv, Janika; Muda, Piibe; Pezzini, Alessandro; Lombardi, Carlo Mario; Tsivgoulis, Georgios; Suihko, Satu; Tolppanen, Heli; Fonseca, Ana Catarina; Martínez‐Sánchez, Patricia;, 2024, Journal of the american heart association: Cardiovascular and cerebrovascular disease, 13, 21, e036254. A1 Journal article (refereed), original research
Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults
Sindre, Rasmus Bach; Gerdts, Eva; Putaala, Jukka; Grymyr, Lisa M.D.; Midtbø, Helga; Almeida, Ana G.; Bech-Hanssen, Odd; Busch, Raila; Eilertsen, Rune K.; Fonseca, Ana Catarina; Hedman, Marja; Huhtakangas, Juha; Jäkälä, Pekka; Lautamäki, Riikka; Lehto, Mika; Martinez-Majander, Nicolas; Redfors, Petra; Sarkanen, Tomi; von Sarnowski, Bettina; Sinisalo, Juha; Virtanen, Marko; Waje-Andreassen, Ulrike; Yesilot, Nilufer; Ylikotila, Pauli; Cramariuc, Dana, 2024, JACC : advances, 3, 4, 100903. A1 Journal article (refereed), original research
Association of the ascending aortic length with acute type A aortic dissection: A retrospective cohort study
Korpela, Tarmo; Salomaa, Elina; Kauhanen, Petteri; Selander, Tuomas; Hedman, Marja; Husso, Annastiina, 2024, Scandinavian journal of surgery, 114, 1, 56-64. A1 Journal article (refereed), original research
Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance
Marttila, Jarkko; Sipola, Petri; Juutilainen, Auni; Sillanmäki, Saara; Hedman, Marja; Kuusisto, Johanna, 2024, High blood pressure and cardiovascular prevention, 31, 4, 389-399. A1 Journal article (refereed), original research
Heparin does not improve myocardial glucose metabolism suppression in [18 F]FDG PET/CT in patients with low β-hydroxybutyrate level
Hartikainen, Suvi; Vepsäläinen, Ville; Laitinen, Tiina; Hedman, Marja; Laitinen, Tomi; Tompuri, Tuomo, 2024, Ejnmmi research, 14, 1, 92. A1 Journal article (refereed), original research
Linear growth pattern can be used to predict ascending aortic aneurysm growth
Viitala, Iida-Mari; Selander, Tuomas; Hedman, Marja; Turtiainen, Johanna, 2024, Scandinavian cardiovascular journal, 58, 1, 2430001. A1 Journal article (refereed), original research
Milloin rytmihäiriöpotilaan jatkokuvantaminen on tarpeen?
Hedman, Marja; Sillanmäki, Saara; Luite, Riho; Liukkonen, Mimmi, 2024, Duodecim, 140, 8, 671-678. A2 Review article, Literature review, Systematic review
Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease
Kiljander, Teemu; Kauhanen, Petteri; Sillanmäki, Saara; Lottonen-Raikaslehto, Line; Husso, Minna; Ylä-Herttuala, Elias; Saari, Petri; Kokkonen, Jorma; Laukkanen, Jari; Mustonen, Pirjo; Hedman, Marja, 2024, Interdisciplinary cardiovascular and thoracic surgery, 38, 5, ivae086. A1 Journal article (refereed), original research
24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults
Tulkki, Lauri; Martinez-Majander, Nicolas; Haapalahti, Petri; Tolppanen, Heli; Sinisalo, Juha; Repo, Olli; Sarkanen, Tomi; Numminen, Heikki; Ryödi, Essi; Ylikotila, Pauli; Roine, Risto O.; Lautamäki, Riikka; Saraste, Antti; Miettinen, Tuuli; Autere, Jaana; Jäkälä, Pekka; Hedman, Marja; Huhtakangas, Juha; Junttola, Ulla; Putaala, Jukka; Pirinen, Jani; The SECRETO Study Group, 2023, Annals of medicine, 55, 1, 2203513. A1 Journal article (refereed), original research
4D Flow Versus 2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves
Hautanen, S; Kiljander, T; Korpela, T; Saari, P; Kokkonen, J; Mustonen, P; Sillanmäki, S; Ylä-Herttuala, E; Husso, M; Hedman, M; Kauhanen, P, 2023, In vivo, 37, 1, 88-98. A1 Journal article (refereed), original research
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
Anttila, Vesa; Saraste, Antti; Knuuti, Juhani; Hedman, Marja; Jaakkola, Pekka; Laugwitz, Karl-Ludwig; Krane, Markus; Jeppsson, Anders; Sillanmäki, Saara; Rosenmeier, Jaya; Zingmark, Pernilla; Rudvik, Anna; Garkaviy, Pavlo; Watson, Christina; Pangalos, Menelas N.; Chien, Kenneth R.; Fritsche-Danielson, Regina; Collén, Anna; Gan, Li-Ming, 2023, Molecular therapy, 31, 3, 866-874. A1 Journal article (refereed), original research
Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation
Valtola, Kati; Hedman, Marja; Kantola, Ilkka; Walls, Susanne; Helisalmi, Seppo; Maria, Maleeha; Raivo, Joose; Auray-Blais, Christiane; Kuusisto, Johanna, 2023, Open heart, 10, 1, e002251. A1 Journal article (refereed), original research
Measuring Cardiac Dyssynchrony with DENSE (Displacement Encoding with Stimulated Echoes)—A Systematic Review
Sillanmäki, Saara; Vainio, Hanna Liina; Ylä-Herttuala, Elias; Husso, Minna; Hedman, Marja, 2023, Reviews in cardiovascular medicine, 24, 9, 261. A2 Review article, Literature review, Systematic review
Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy
Sarin, Jaakko K; Kiema, Miika; Luoto, Emma-Sofia; Husso, Annastiina; Hedman, Marja; Laakkonen, Johanna P; Torniainen, Jari, 2023, Journal of surgical research, 287, 82-89. A1 Journal article (refereed), original research
Twenty years’ experience of type B aortic dissections: a population-based national registry study from Finland
Toimela, Juhana Mikael; Sedha, Jagdeep; Hedman, Marja; Valtola, Antti; Selander, Tuomas; Husso, Annastiina, 2023, Interdisciplinary cardiovascular and thoracic surgery, 37, 5, ivad184. A1 Journal article (refereed), original research
Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease
Hämäläinen, Hanna; Laitinen, Tiina M; Hedman, Marja; Hedman, Antti; Kivelä, Antti; Laitinen, Tomi P, 2022, Clinical physiology and functional imaging, 42, 6, 413-421. A1 Journal article (refereed), original research
Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up
Kauhanen, Petteri; Korpela, Tarmo; Hedman, Marja, 2022, European journal of radiology, 150, 110234. A1 Journal article (refereed), original research
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms
Jauhiainen, Suvi; Kiema, Miika; Hedman, Marja; Laakkonen, Johanna P, 2022, Arteriosclerosis, thrombosis, and vascular biology, 42, 7, 811-818. A2 Review article, Literature review, Systematic review
Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report
Sillanmäki, Saara; Istomina, Maria; Husso, Annastiina; Hedman, Marja, 2022, European heart journal: Case reports, 6, 4, ytac171. A1 Journal article (refereed), original research
Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study
Prescott, Eva; Angerås, Oskar; Erlinge, David; Grove, Erik L; Hedman, Marja; Jensen, Lisette O; Pernow, John; Saraste, Antti; Åkerblom, Axel; Svedlund, Sara; Rudvik, Anna; Knöchel, Jane; Lindstedt, Eva-Lotte; Garkaviy, Pavlo; Gan, Li-Ming; Gabrielsen, Anders, 2022, International journal of cardiology, 365, 34-40. A1 Journal article (refereed), original research
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Kiema, Miika; Sarin, Jaakko K; Kauhanen, S Petteri; Torniainen, Jari; Matikka, Hanna; Luoto, Emma-Sofia; Jaakkola, Pekka; Saari, Petri; Liimatainen, Timo; Vanninen, Ritva; Ylä-Herttuala, Seppo; Hedman, Marja; Laakkonen, Johanna P, 2022, Frontiers in physiology, 13, 934941. A1 Journal article (refereed), original research
Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals
Klumpp, Matthias; Hintze, Marcus; Immonen, Milla; Ródenas-Rigla, Francisco; Pilati, Francesco; Aparicio-Martínez, Fernando; Çelebi, Dilay; Liebig, Thomas; Jirstrand, Mats; Urbann, Oliver; Hedman, Marja; Lipponen, Jukka A.; Bicciato, Silvio; Radan, Anda-Petronela; Valdivieso, Bernardo; Thronicke, Wolfgang; Gunopulos, Dimitrios; Delgado-Gonzalo, Ricard, 2021, Healthcare, 9, 8, 961. A1 Journal article (refereed), original research
Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position
Kauhanen, S Petteri; Saari, Petri; Korpela, Tarmo; Liimatainen, Timo; Vanninen, Ritva; Hedman, Marja, 2021, Acta radiologica, [First Published July 25, 2021], 1-9. A1 Journal article (refereed), original research
Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation
Korpela, Tarmo; Kauhanen, S Petteri; Kariniemi, Elina; Saari, Petri; Liimatainen, Timo; Jaakkola, Pekka; Vanninen, Ritva; Hedman, Marja, 2021, European journal of cardio-thoracic surgery, 2022; 61, 2, 395-402. A1 Journal article (refereed), original research
Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population
Kauhanen, S. Petteri; Liimatainen, Timo; Korhonen, Miika; Parkkonen, Johannes; Vienonen, Juska; Vanninen, Ritva; Hedman, Marja, 2021, In vivo, 35, 4, 2177-2185. A1 Journal article (refereed), original research
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo, 2021, Biomolecules, 11, 3, 452. A1 Journal article (refereed), original research
Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease
Hämäläinen, H; Corovai, A; Laitinen, J; Laitinen, TM; Hedman, M; Hedman, A; Kivelä, A; Laitinen, TP, 2020, Journal of nuclear cardiology, 2021; 28, 6, 3010-3020. A1 Journal article (refereed), original research
Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events
Onatsu, Juha; Vanninen, Ritva; Jäkälä, Pekka; Mustonen, Pirjo; Pulkki, Kari; Korhonen, Miika; Hedman, Marja; Höglund, Kina; Blennow, Kaj; Zetterberg, Henrik; Herukka, Sanna-Kaisa; Taina, Mikko, 2020, In vivo, 34, 5, 2577-2586. A1 Journal article (refereed), original research
Effect of middle cerebral artery territory ischemic stroke on QT interval
Simula Sakari, Muuronen Antti T, Taina Mikko, Jäkälä Pekka, Sipola Petri, Vanninen Ritva, Hedman Marja, 2013, Journal of stroke and cerebrovascular diseases, [Epub ahead of print], 1-7. A1 Journal article (refereed), original research
Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer
Hedman M, Muona K, Hedman A, Kivelä A, Syvänne M, Eränen J, Rantala A, Stjernvall J, Nieminen MS, Hartikainen J, Ylä-Herttuala S, 2009, Gene therapy, 16, 629-634. A1 Journal article (refereed), original research
New technologies in cardiovascular research gene therapy
Hedman M, Turunen MP, Ylä-Herttuala S, 2006, Pasterkamp G, de Kleijn DPV, Cardiovascular Research. New Technologies, Methods, and Applications, 85-101. A3 Book section, Chapters in research books
Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy
Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M, Ylä-Herttuala S, 2006, Current drug safety, 1, 253-257. A1 Journal article (refereed), original research
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries
Bhardwaj S, Roy H, Kärpänen T, Hi Y, Jauhiainen S, Hedman M, Alitalo K, Ylä-Herttuala S, 2005, Gene therapy, 12, 5, 388-394. A1 Journal article (refereed), original research
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart
Rutanen J, Rissanen TT, Markkanen JE, Gruchala M, Silvennoinen P, Kivelä A, Hedman A, Hedman M, Heikura T, Ordén M-R, Stacker SA, Achen MG, Hartikainen J, Ylä-Herttuala S., 2004, Circulation, 109, 1029-1035. A1 Journal article (refereed), original research
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue
Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, Kokina I, Achen MG, Stacker SA, Hedman M, Alitalo K, Ylä-Herttuala S, 2003, Human gene therapy, 14, 1451-1462. A1 Journal article (refereed), original research
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]
Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S, 2003, Circulation, 107, 2677-2683. A1 Journal article (refereed), original research
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S, 2002, Vascular medicine, 7, 5-11. A1 Journal article (refereed), original research
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S, 2002, Molecular therapy, 6, 1, 127-133. A1 Journal article (refereed), original research
Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods
Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S, 2000, Faseb journal, 14, 2230-2236. A1 Journal article (refereed), original research
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S, 2000, Human gene therapy, 11, 263-270. A1 Journal article (refereed), original research
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease
Hedman M, Ylä-Herttuala S, 2000, Drugs of today, 36, 609-617. A1 Journal article (refereed), original research
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer
Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S, 2000, Vascular medicine, 5, 41-48. A1 Journal article (refereed), original research
Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta
Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S, 2000, Circulation, 102, 2262-2268. A1 Journal article (refereed), original research
Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes
Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S, 2000, Journal of gene medicine, 2, 52-60. A1 Journal article (refereed), original research
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res
Pakkanen TM, Laitinen M, Hippeläinen M, Kallionpää H, Lehtolainen P, Leppänen P, Luoma JS, Tarvainen R, Alhava E, Ylä-Herttuala S, 1999, Gene therapy, 6, 34-41. A1 Journal article (refereed), original research
Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies
Laitinen M, 1999, Kuopio University Publications D. Medical Sciences. G5 Doctoral dissertation (article)
Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment
Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S, 1999, Pharmacological research, 40, 5, 451-457. A1 Journal article (refereed), original research
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S, 1998, Human gene therapy, 9, 1481-1486. A1 Journal article (refereed), original research
Adventitial gene transfer to arterial wall
Laitinen M, Ylä-Herttuala S, 1998, Pharmacological research, 37, 4, 251-254. A1 Journal article (refereed), original research
Adventitial gene transfer to rabbit carotid arteries
Laitinen M, Ylä-Herttuala S, 1998, Jacotot B, Mathé D, Fruchart J-C, Atherosclerosis XI. XIth International Symposium on Atherosclerosis, 689-691. A4 Conference proceedings
Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings
Manninen HI, Vanninen RL, Laitinen M, Räsänen H, Vainio P, Luoma JS, Pakkanen T, Tulla H, Ylä-Herttuala S, 1998, Investigative radiology, 33, 8, 464-471. A1 Journal article (refereed), original research
Vascular gene transfer for the treatment of restenosis and atherosclerosis
Laitinen M, Ylä-Herttuala S, 1998, Current opinion in lipidology, 9, 465-469. A1 Journal article (refereed), original research
Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses
Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agraval R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Ylä-Herttuala S, 1997, Human gene therapy, 8, 1645-1650. A1 Journal article (refereed), original research
Genteknologins möjligheter vid hjärt- och kärlsjukdomar
Laitinen M, Ylä-Herttuala S, 1997, Finsk tidskrift, 9-10, 527-536. D1 Article in a trade journal
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S, 1997, Human gene therapy, 8, 1737-1744. A1 Journal article (refereed), original research

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Marja Hedman

Research groups

Keywords

Combining ascending aortic diameter and length and their growth rates improves the prediction of type A aortic dissection

Growth patterns of ascending aortic aneurysms

Impact of Carina Width on Re‐Ablation Rate of Atrial Fibrillation After Primary Cryoballoon‐Ablation

The effect of age and sex on T1, T2, and T2* relaxation time constants in cardiac MRI in healthy Finnish population

Cardiometabolic disorders affect myocardial [18F]fluorodeoxyglucose uptake– impact on diagnostic PET/CT imaging

Nousevan aortan laajentuman kuvantaminen ja seuranta ESC 2024 suosituksen mukaan

Prevalence and risk factors of thoracic aortic dilatation detected incidentally in adjuvant radiotherapy planning CT scans in patients with breast cancer

SKS Atlas ylilääkärikysely 2024 - muutoksen tuulia

Secondary aortic intervention may not impair survival in patients treated with TEVAR for type B aortic dissection: A Finnish national registry study

Uudet sydänlihaksen fibroosia ja supistumista arvioivat magneettikuvausmenetelmät sydämen vajaatoiminnan diagnostiikassa

Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study

Association of Hypertension With Early‐Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case–Control Study

Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults

Association of the ascending aortic length with acute type A aortic dissection: A retrospective cohort study

Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance

Heparin does not improve myocardial glucose metabolism suppression in [18 F]FDG PET/CT in patients with low β-hydroxybutyrate level

Linear growth pattern can be used to predict ascending aortic aneurysm growth

Milloin rytmihäiriöpotilaan jatkokuvantaminen on tarpeen?

Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease

24-hour ambulatory blood pressure and cryptogenic ischemic stroke in young adults

4D Flow Versus 2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves

Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

Measuring Cardiac Dyssynchrony with DENSE (Displacement Encoding with Stimulated Echoes)—A Systematic Review

Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy

Twenty years’ experience of type B aortic dissections: a population-based national registry study from Finland

Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease

Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up

Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms

Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report

Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta

Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals

Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position

Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation

Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death

Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease

Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events

Effect of middle cerebral artery territory ischemic stroke on QT interval

Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

New technologies in cardiovascular research gene therapy

Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy

Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart

Angiogenic responses of vascular endothelial growth factors in periadventitial tissue

Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study

Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

Gene therapy for the treatment of peripheral vascular disease and coronary artery disease

Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer

Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta

Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res

Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies

Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

Adventitial gene transfer to arterial wall

Adventitial gene transfer to rabbit carotid arteries

Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings

Vascular gene transfer for the treatment of restenosis and atherosclerosis

Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses

Genteknologins möjligheter vid hjärt- och kärlsjukdomar

VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries