Cardiovascular imaging and predictive markers
Leaders
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Marja Hedman
ProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Saara Sillanmäki
Senior ResearcherInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
PROJECTS
DilAo Project Research investigating factors that predict aortic dilation and rupture
SUB‑PROJECTS
DilAo‑Pre – Experimental study investigating the pathophysiology of aortic dilation and imaging parameters predicting rupture (UEF; A. I. Virtanen Institute)
DilAo‑TAV – Study using modern 4D flow MRI to identify predictors of aortic dilation in patients with a normal tricuspid aortic valve (KYS)
DilAo‑BAV – Study using modern 4D flow MRI to identify predictors of aortic dilation in patients with a congenital bicuspid aortic valve + aortic coarctation (KYS, K‑SKS)
DilAo‑Ela – Study assessing aortic rupture susceptibility using biomechanical methods and histopathology (KYS, UEF; Department of Applied Physics and A. I. Virtanen Institute)
DilAo‑Sim – Study assessing aortic rupture susceptibility through mathematical modeling and pressure‑condition simulations (KYS, JAMK)
DiReA‑Digitwin – Digital and real‑elastic twin for predicting aortic dilation and rupture risk
Cardio‑Fib Project – Cardiac muscle fibrosis imaging – Development of modern radiation‑free and contrast‑free imaging methods and analysis of computational fibrosis in relation to cardiac disease prognosis and treatment outcomes
Translational cardiac perfusion imaging using different imaging techniques
Cooperation
Teams and collaborators
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PO BOX 100, 70029 KYS, Finland
Heart Center, Heart and lung surgery
- Marja Hedman, MD, professor, leader of the study
- Annastiina Husso, MD, PhD, heart surgeon
- Antti Valtola, MD, adj. professor, heart surgeon
- Juhana Toimela, MD, PhD researcher
- Tarmo Korpela, BMSc, PhD researcher
- Iida Viitala, MD, PhD researcher
- Lari Kujanen, BSc, study coordinator
Clinical Imaging Center
Clinical Radiology and Clinical Physiology and Nuclear Imaging
- Petteri Kauhanen, MD, PhD, post doc researcher
- Saara Sillanmäki, MD, PhD, post doc researcher
- Line Lottonen-Raikaslehto, MD, PhD, post doc researcher
- Minna Husso, MSc, PhD, hospital physicist
- Elias Ylä-Herttuala, MSc, PhD, hospital physicist
- Petri Saari, MD, PhD, vascular radiologist
- Hanna Matikka, MSc, PhD, hospital physicist
- Sami Väänänen, MSc, Phd, hospital physicist
Department of Anestesiology and Intensive care
- Petri Toroi, BSc, study nurse
- Maarit Lång, MD, PhD, clinical collaborator
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PO BOX 1627, 70211 Kuopio, Finland
A.I.Virtanen Institute Molecular Sciences
- Johanna Laakkonen, PhD, associate professor
- Miika Kiema, MSc, doctoral researcher
- Heta Rasinkangas, medical student, doctoral researcher
- Akseli Kivistö-Rahnasto, medical student, researcher
- Emma-Sofia Luoto, medical student, researcher
- Suvi Jauhiainen, PhD, project researcher
- Jussi Tohka, PhD, professor of biomedical image analysis
Department of Applied Physics
- Jaakko Sarin, PhD, docent
- Jari Torniainen, PhD, post doc researcher
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PO BOX 207, 40101 Jyväskylä, Finland
Industrial engineering
- Matti Kurki, adjunct professor, principal researcher
- Tero Tuovinen, adjunct professor, researcher
- Tomi Nieminen, lector, researcher
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17177 Stockholm, Sweden
Dept. of Molecular Medicine and Surgery
- David Marlevi, MD, PhD, post doc researcher
- Martin Ugander, MD, professor
- Klara Blomdahl, MD, PhD researcher
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- Martin Ugander, MD, professor
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Mulhouse, France
- Frederic Heim, MS, professor
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- Aortic dilatation associates with flow displacement and increased circumferential wall shear stress in patients without aortic stenosis: A prospective clinical study
- High prevelance of ascending aortic dilatation in a consecutive coronary CT angiography patient population
- A smaller heart-aorta-angle associates with ascending aortic dilatation and increases wall shear stress
- Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population
- Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position
- Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
- Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up
- Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation
Keywords
Leaders
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Marja Hedman
ProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Saara Sillanmäki
Senior ResearcherInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Senior Researchers
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Johanna Laakkonen
Associate ProfessorA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Suvi Jauhiainen
Project ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Elias Ylä-Herttuala
Postdoctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Doctoral Researchers
Research Nurses
Other group members
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Julia Pulkkinen
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Ansa Hakala
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Tarmo Korpela
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iida Kotanen