Akash Mali
Postdoctoral Researcher
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
I am a postdoctoral researcher at the University of Eastern Finland working in the field of neuroscience, with a focus on human brain organoids, neuroimmunology, and Alzheimer’s disease. My research aims to develop advanced human cortical organoid models integrated with iPSC-derived microglia to investigate the cellular and molecular mechanisms of neurodegeneration.
My work combines stem cell biology, nanomedicine, advanced microscopy, proteomics, and 3D image analysis to study neuron–glia interactions, amyloid pathology, synaptic dysfunction, and neuroinflammatory responses. I am also interested in engineering next-generation programmable neuroimmune organoids by integrating synthetic biology and computational approaches to improve disease modeling, drug discovery, and precision medicine.
My broader research interests include brain organoids, microglial biology, neurodegenerative diseases, synthetic biology, nanotechnology, biomaterials, and advanced imaging.
Research groups
Publications
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BTK inhibitor ibrutinib reduces LPS-induced inflammation in C8-B4 microglia
Das, Debanjan; Mali, Akash S.; Greco, Denise; Michaličková, Danica; Novotný, Jiří; Slanař, Ondřej, 2025, Excli journal, 24, 1482-1499. A1 Journal article (refereed), original research -
Biopsies from Idiopathic Normal Pressure Hydrocephalus Patients as a Window to the Events of Early Alzheimer's disease: Beta‐amyloid and Tau Pathologies Alter Synaptic Transmission in Human Brain
Dougalis, Antonios; Abushik, Polina; Pelkonen, Anssi; Giudice, Luca; Gomez‐Budia, Mireia; Novosolova, Nataliia; Välimäki, Nelli‐Noora; Rezaie, Mohammad; Nurkhametova, Dilyara; Giniatullina, Raisa; Shakirzyanova, Anastasia; Mali, Akash; de Kock, Christiaan PJ; Mertens, Eline J; Mansvelder, Huibert D; Stevens, Beth; Macosko, Evan; Hiltunen, Mikko; Rauramaa, Tuomas; Leinonen, Ville; Malm, Tarja, 2025, Alzheimer's & dementia. Abstract -
Microglial involvement in autism spectrum disorder: insights from human data and iPSC models
Michels, Susanne; Mali, Akash; Jäntti, Henna; Rezaie, Mohammad; Malm, Tarja, 2025, Brain behavior and immunity, 130, 106071. A1 Journal article (refereed), original research
