Anssi Lipponen

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Thomassen, Jesper Qvist; Leonard, Hampton; Ulms, Brittany; Grenier-Boley, Benjamin; Heikkinen, Sami; Garcia-González, Pablo; Castillo-Morales, Atahualapa; Kikuchi, Masataka; Gim, Jungsoo; Cao, Han; Küçükali, Fahri; Amin, Najaf; Yoon, Dabin; de Rojas, Itziar; Alvarez Jerez, Pilar; Alvarez, Victoria; Arosio, Beatrice; Bellenguez, Céline; Bergh, Sverre; Billingsley, Kimberley; Blauwendraat, Cornelis; Boada, Merce; Borroni, Barbara; Bossù, Paola; Bullido, María J.; Daniele, Antonio; Carracedo, Ángel, 2026, Nature genetics, [Published: 14 September 2026], 1-19. A1 Journal article (refereed), original research

Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen

Heikkinen, Sami; Julkunen, Valtteri; Martiskainen, Henna; Takalo, Mari; Solje, Eino; Leinonen, Ville; Haapasalo, Annakaisa; Lipponen, Anssi; Hiltunen, Mikko, 2026, Molecular psychiatry, [Published: 12 June 2026], 1-10. A2 Review article, Literature review, Systematic review

Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus

Penkauskas, Andrius; Kuukkanen, Eemeli; Lipponen, Anssi; Hakumäki, Juhana; Koikkalainen, Juha; Lotjonen, Jyrki; Erkkilä, Lauri; Tohka, Jussi; Miettinen, Pauli; Leinonen, Ville, 2026, Fluids and barriers of the cns, 23, 1, 56. A1 Journal article (refereed), original research

Comparative core-genome MLST of vancomycin-resistant Enterococcus faecium supports the utility of wastewater-based surveillance: a pilot study

Al-Mustapha, Ahmad Ibrahim; Lindholm, Laura; Laukkanen-Ninios, Riikka; Johansson, Venla; Tiwari, Ananda; Heljanko, Viivi; Lehto, Kirsi-Maarit; Lipponen, Anssi; Oikarinen, Sami; Pitkänen, Tarja; Heikinheimo, Annamari, 2026, Bmc microbiology, 26, 259. A1 Journal article (refereed), original research

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients

Luikku, Antti J; Matikka, Sara; Heikkinen, Sami; Lipponen, Anssi; Luostarinen, Katja; Koivisto, Timo; Leinonen, Ville; Huttunen, Jukka; Jyrkkänen, Henna‐Kaisa, 2026, Pain practice, 26, 4, 1-8. A1 Journal article (refereed), original research

Reduced risk of shunt revision with adjustable valves: a population-based cohort study over three decades

Oksa, Siiri; Kasurinen, Roosa; Lipponen, Anssi; Leinonen, Ville; Luikku, Antti J, 2026, Acta neurochirurgica, 168, 1, 29. A1 Journal article (refereed), original research

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

Oh, Hamilton Se‐Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R; Chen, Jingsha; Guldner, Ian H; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Guen, Yann Le; Trelle, Alexandra N.; Herukka, Sanna‐Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J; Poston, Kathleen L.; Mormino, Elizabeth C.; Wagner, Anthony D.; Wilson, Ted N.; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenb, 2025, Alzheimer's & dementia. Poster

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Oh, Hamilton Se Hwee; Urey, Deniz Yagmur; Karlsson, Linda; Zhu, Zeyu; Shen, Yuanyuan; Farinas, Amelia; Timsina, Jigyasha; Duggan, Michael R.; Chen, Jingsha; Guldner, Ian H.; Morshed, Nader; Yang, Chengran; Western, Daniel; Ali, Muhammad; Le Guen, Yann; Trelle, Alexandra; Herukka, Sanna Kaisa; Rauramaa, Tuomas; Hiltunen, Mikko; Lipponen, Anssi; Luikku, Antti J.; Poston, Kathleen L.; Mormino, Elizabeth; Wagner, Anthony D.; Wilson, Edward N.; Channappa, Divya; Leinonen, Ville; Stevens, Beth; Ehrenb, 2025, Nature medicine, 31, 5, 1592-1603. A1 Journal article (refereed), original research

Development of an online portal for wastewater-based surveillance of multiple pathogens – A WastPan Study

Lipponen, Anssi; Luomala, Oskari; Juutinen, Aapo; Hokajärvi, Anna-Maria; Kolehmainen, Aleksi; Oksanen, Juha; Karri, Sirene; Möttönen, Teemu; Savolainen-Kopra, Carita; Heikinheimo, Annamari; Oikarinen, Sami; Pitkänen, Tarja; Lehto, Kirsi-Maarit; WastPan Study Group, 2025, Environment international, 200, 109545. A1 Journal article (refereed), original research

Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease

Lipponen, Anssi; Heikkinen, Sami; Räsänen, Joel; Macosko, Evan; Malm, Tarja; Hiltunen, Mikko; Leinonen, Ville, 2025, Alzheimer's & dementia. Poster

Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

Vanninen, Aleksi; Erkkilä, Lauri; Kokkola, Tarja; Selander, Tuomas; Koivisto, Anne M; Kokki, Merja; Musialowicz, Tadeusz; Lipponen, Anssi; Hiltunen, Mikko; Hakumäki, Juhana; Herukka, Sanna-Kaisa; Rauramaa, Tuomas; Leinonen, Ville, 2025, Journal of Alzheimer's disease, 105, 2, 397-406. A1 Journal article (refereed), original research

Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study

Räsänen, Joel; Helisalmi, Seppo; Heikkinen, Sami; Raivo, Joose; Korhonen, Ville E.; Martiskainen, Henna; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Céline; Oinas, Minna; Avellan, Cecilia; Frantzen, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M.; Julkunen, Valtteri; Portaankorva, Anne M.; Mannermaa, Arto; Soininen, Hilkka; Jääskeläinen, Juha E.; Lambert, Jean-Cha, 2025, Fluids and barriers of the cns, 22, 1, 17. A1 Journal article (refereed), original research

Mitigation of Acute Seizures and Neuropathology after Traumatic Brain Injury by Structure-Based Discovery-Identified Drugs

Kajevu, Natallie; Banuelos, Ivette; Andrade, Pedro; Hämäläinen, Elina; Sabatier, Laureano; Couyoupetrou, Manuel; Villalba, María Luisa; Gavernet, Luciana; Lipponen, Anssi; Natunen, Teemu; Puhakka, Noora; Hiltunen, Mikko; Talevi, Alan; Pitkänen, Asla, 2025, Journal of neurotrauma, 42, 15-16, 1433-1452. A1 Journal article (refereed), original research

Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy

Puhakka, Noora; Cifelli, Pierangelo; Ruffolo, Gabriele; Gaeta, Alessandro; Roseti, Cristina; De Iacovo, Angela; Tiilikainen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Pitkänen, Asla; Palma, Eleonora, 2025, Experimental neurology, 387, 115183. A1 Journal article (refereed), original research

Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli

Al-Mustapha, Ahmad Ibrahim; Tiwari, Ananda; Laukkanen-Ninios, Riikka; Lehto, Kirsi-Maarit; Oikarinen, Sami; Lipponen, Anssi; Pitkänen, Tarja; Heikinheimo, Annamari; WastPan Study Group, 2025, Scientific reports, 15, 1, 7400. A1 Journal article (refereed), original research

Detection of SARS-COV-2 variants and their proportions in wastewater samples using next-generation sequencing in Finland

Lipponen, Anssi; Kolehmainen, Aleksi; Oikarinen, Sami; Hokajärvi, Anna-Maria; Lehto, Kirsi-Maarit; Heikinheimo, Annamari; Halkilahti, Jani; Juutinen, Aapo; Luomala, Oskari; Smura, Teemu; Liitsola, Kirsi; Blomqvist, Soile; Savolainen-Kopra, Carita; Pitkänen, Tarja; Länsivaara, Annika; Hyder, Rafiqul; Janhonen, Erja; Heikinheimo, Annamari; Heljanko, Viivi; Johansson, Venla; Kurittu, Paula; Tiwari, Ananda; Al-Mustapha, Ahmad; Sarekoski, Anniina; Möttönen, Teemu; Räisänen, Kati; Savolainen-Kopra, Ca, 2024, Scientific reports, 14, 1, 7751. A1 Journal article (refereed), original research

Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort

Räsänen, Joel; Heikkinen, Sami; Mäklin, Kiira; Lipponen, Anssi; Kuulasmaa, Teemu; Mehtonen, Juha; Korhonen, Ville E; Junkkari, Antti; Grenier-Boley, Benjamin; Bellenguez, Celine; Oinas, Minna; Avellan, Cecilia; Frantzén, Janek; Kotkansalo, Anna; Rinne, Jaakko; Ronkainen, Antti; Kauppinen, Mikko; von und zu Fraunberg, Mikael; Lönnrot, Kimmo; Satopää, Jarno; Perola, Markus; Koivisto, Anne M; Julkunen, Valtteri; Portaankorva, Anne M; Mannermaa, Arto; Soininen, Hilkka; Helisalmi, Seppo; Jääskeläinen, 2024, Neurology, 103, 5, e209694. A1 Journal article (refereed), original research

The effects of RT-qPCR standards on reproducibility and comparability in monitoring SARS-CoV-2 levels in wastewater

Juutinen, Aapo; Tiwari, Ananda; Hokajärvi, Anna-Maria; Luomala, Oskari; Kolehmainen, Aleksi; Nurmi, Eveliina; Salmivirta, Elisa; Pitkänen, Tarja; Lipponen, Anssi, 2024, Scientific reports, 14, 1, 25582. A1 Journal article (refereed), original research

Gene Expression Profile as a Predictor of Seizure Liability

Lipponen, Anssi; Kajevu, Natallie; Natunen, Teemu; Ciszek, Robert; Puhakka, Noora; Hiltunen, Mikko; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 4, 4116. A1 Journal article (refereed), original research

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Kajevu, Natallie; Lipponen, Anssi; Andrade, Pedro; Bañuelos, Ivette; Puhakka, Noora; Hämäläinen, Elina; Natunen, Teemu; Hiltunen, Mikko; Pitkänen, Asla, 2023, International journal of molecular sciences, 24, 18, 14049. A1 Journal article (refereed), original research

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

Hiltunen, Johanna; Ndode-Ekane, Xavier Ekolle; Lipponen, Anssi; Drexel, Meinrad; Sperk, Günther; Puhakka, Noora; Pitkänen, Asla, 2021, Neuroscience, 475, 52-72. A1 Journal article (refereed), original research

A systems biology approach for identification and stepwise validation of pharmacotherapy candidates for traumatic brain injury

Lipponen, Anssi, 2020, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)

Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury

Kyyriäinen, Jenni; Tapiala, Jesse; Lipponen, Anssi; Ekolle Ndode-Ekane, Xavier; Pitkänen, Asla, 2020, Neuroscience letters, 729, 134935. A1 Journal article (refereed), original research

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Kyyriäinen, J; Bolkvadze, T; Koivisto, H; Lipponen, A; Pérez, LO; Ekolle Ndode-Ekane, X; Tanila, H; Pitkänen, A, 2019, Epilepsy research, 151, 67-74. A1 Journal article (refereed), original research

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Das Gupta, S; Lipponen, A; Paldanius, KMA; Puhakka, N; Pitkänen, A, 2019, Scientific reports, 9, 20208. A1 Journal article (refereed), original research

Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies

Karttunen, J; Heiskanen, M; Lipponen, A; Poulsen, D; Pitkänen, A, 2019, International journal of molecular sciences, 20, 6, 1259. A2 Review article, Literature review, Systematic review

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Lipponen, A; Natunen, T; Hujo, M; Ciszek, R; Hämäläinen, E; Tohka, J; Hiltunen, M; Paananen, J; Poulsen, D; Kansanen, E; Ekolle Ndode-Ekane, X; Levonen, AL; Pitkänen, A, 2019, International journal of molecular sciences, 20, 21, 5395. A1 Journal article (refereed), original research

Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird

Soulsbury, Carl D; Lipponen, Anssi; Wood, Kristie; Mein, Charles A; Hoffman, Joseph I; Lebigre, Christophe, 2018, Ecology and evolution, 8, 13, 6547-6557. A1 Journal article (refereed), original research

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen

Pulkkinen, Katja; Pekkala, Nina; Ashrafi, Roghaieh; Hämäläinen, Dorrit M; Nkembeng, Aloysius N; Lipponen, Anssi; Hiltunen, Teppo; Valkonen, Janne K; Taskinen, Jouni, 2018, Fems microbiology ecology, 94, 5, fiy060. A1 Journal article (refereed), original research

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Karttunen, Jenni; Heiskanen, Mette; Navarro-Ferrandis, Vicente; Das Gupta, Shalini; Lipponen, Anssi; Puhakka, Noora; Rilla, Kirsi; Koistinen, Arto; Pitkänen, Asla, 2018, Journal of extracellular vesicles, 2019; 8, 1, 1555410. A1 Journal article (refereed), original research

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Lipponen, Anssi; El-Osta, Assam; Kaspi, Antony; Ziemann, Mark; Khurana, Ishant; Harikrishnan, K N; Navarro-Ferrandis, Vicente; Puhakka, Noora; Paananen, Jussi; Pitkänen, Asla, 2018, Acta neuropathologica communications, 6, 17. A1 Journal article (refereed), original research

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

Lipponen Anssi, Paananen Jussi, Puhakka Noora, Pitkänen Asla, 2016, Scientific reports, 6, 31570. A1 Journal article (refereed), original research

High Nutrient Concentration Can Induce Virulence Factor Expression and Cause Higher Virulence in an Environmentally Transmitted Pathogen

Penttinen Reetta, Kinnula Hanna, Lipponen Anssi, Bamford Jaana KH, Sundberg Lotta-Riina, 2016, Microbial ecology, 72, 4, 955-964. A1 Journal article (refereed), original research

Gender issues in antiepileptogenic treatments

Pitkänen A, Huusko N, Ndode-Ekane XE, Kyyriäinen J, Lipponen A, Lipsanen A, Sierra A, Bolkvadze T, 2014, Neurobiology of disease, 2014 Jun 6 ePub ahead of print, pii: S0969-9961(14)00163-6. A1 Journal article (refereed), original research

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APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen

Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus

Comparative core-genome MLST of vancomycin-resistant Enterococcus faecium supports the utility of wastewater-based surveillance: a pilot study

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients

Reduced risk of shunt revision with adjustable valves: a population-based cohort study over three decades

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Development of an online portal for wastewater-based surveillance of multiple pathogens – A WastPan Study

Discovery of Novel CSF Clearance Mechanism of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease

Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study

Mitigation of Acute Seizures and Neuropathology after Traumatic Brain Injury by Structure-Based Discovery-Identified Drugs

Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy

Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli

Detection of SARS-COV-2 variants and their proportions in wastewater samples using next-generation sequencing in Finland

Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort

The effects of RT-qPCR standards on reproducibility and comparability in monitoring SARS-CoV-2 levels in wastewater

Gene Expression Profile as a Predictor of Seizure Liability

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

Regulation of parvalbumin interactome in the perilesional cortex after experimental traumatic brain injury

A systems biology approach for identification and stepwise validation of pharmacotherapy candidates for traumatic brain injury

Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility

Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury

Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury - Lessons Learned

Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets

High Nutrient Concentration Can Induce Virulence Factor Expression and Cause Higher Virulence in an Environmentally Transmitted Pathogen

Gender issues in antiepileptogenic treatments