Anu Kauppinen
Professor
School of Pharmacy, Faculty of Health Sciences
[email protected] | +358 40 355 3216
Research groups
Publications
137/137 items-
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research -
Fibrotic Changes in Rhegmatogenous Retinal Detachment
Harju, Niina; Kauppinen, Anu; Loukovaara, Sirpa, 2025, International journal of molecular sciences, 26, 3, 1025. A2 Review article, Literature review, Systematic review -
Photoaging: UV radiation-induced cGAS-STING signaling promotes the aging process in skin by remodeling the immune network
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2025, Biogerontology, 26, 4, 123. A2 Review article, Literature review, Systematic review -
Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery
Harju, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu, 2024, International ophthalmology, 44, 1, 158. A1 Journal article (refereed), original research -
Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells
Mysore, Yashavanthi; Hytti, Maria; Deen, Ashik Jawahar; Ranta-aho, Sofia; Piippo, Niina; Toppila, Maija; Loukovaara, Sirpa; Harju, Niina; Kauppinen, Anu, 2024, Cell biochemistry and biophysics, 82, 2, 1523-1536. A1 Journal article (refereed), original research -
Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage
Toppila, Maija; Ranta-aho, Sofia; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu, 2024, Cells, 13, 17, 1433. A1 Journal article (refereed), original research -
Simvastatin and amfenac act as immunomodulators during induced epithelial‐mesenchymal transition in ARPE‐19 cells
Harju (ex‐Bhattarai), Niina; Loukovaara, Sirpa; Kauppinen, Anu, 2024, Acta ophthalmologica. Abstract -
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2024, European journal of pharmaceutical sciences, 203, 106937. A1 Journal article (refereed), original research -
Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2024, Ageing research reviews, 97, 102296. A2 Review article, Literature review, Systematic review -
Autophagy in the eye: from physiology to pathophysology
Liton, Paloma B; Boesze-Battaglia, Kathleen; Boulton, Michael E; Boya, Patricia; Ferguson, Thomas A; Ganley, Ian G; Kauppinnen, Anu; Laurie, Gordon W.; Mizushima, Noboru; Morishita, Hideaki; Russo, Rossella; Sadda, Jaya; Shyam, Rajalekshmy; Sinha, Debasish; Thompson, Debra A.; Zacks, David N., 2023, Autophagy reports, 2, 1, 2178996. A2 Review article, Literature review, Systematic review -
Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu, 2023, Biochemical pharmacology, 216, 115790. A1 Journal article (refereed), original research -
Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients
Karema-Jokinen, Viivi; Koskela, Ali; Hytti, Maria; Hongisto, Heidi; Viheriälä, Taina; Liukkonen, Mikko; Torsti, Tommi; Skottman, Heli; Kauppinen, Anu; Nymark, Soile; Kaarniranta, Kai, 2023, Journal of biological chemistry, 299, 6, 104770. A1 Journal article (refereed), original research -
The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance
Toppila, Maija; Hytti, Maria; Korhonen, Eveliina; Ranta-aho, Sofia; Harju, Niina; Forsberg, Markus M.; Kaarniranta, Kai; Jalkanen, Aaro; Kauppinen, Anu, 2023, Antioxidants, 12, 6, 1279. A1 Journal article (refereed), original research -
Amfenac together with simvastatin reduces IL-8 and MCP-1 and increases VEGF release from ARPE-19 cells upon inflammatory conditions
Bhattarai, Niina; Hytti, Maria; Kolari, Onni; Nisula, Hilkka; Loukovaara, Sirpa; Kauppinen, Anu, 2022, Acta ophthalmologica. Abstract -
Askeleita kohti verkkokalvon irtauman jälkeisen arven lääkkeellistä estoa
Loukovaara, Sirpa; Gucciardo, Erika; Korhonen, Ani; Öhman, Tiina; Kauppinen, Anu, 2022, Duodecim, 138, 5, 408-418. A2 Review article, Literature review, Systematic review -
Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders
Leinonen, Henri; Zhou, Tianwei Ellen; Ballios, Brian G.; Kauppinen, Anu; Fu, Zhongjie, 2022, Frontiers in neuroscience, 16, 1102385. B1 Non-refereed journal articles -
Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
Sridevi Gurubaran, Iswariyaraja; Hytti, Maria; Kaarniranta, Kai; Kauppinen, Anu, 2022, Antioxidants, 11, 7, 1288. A1 Journal article (refereed), original research -
Hydroquinone increases risk for retinal pigment epithelial (RPE) cell degeneration
Bhattarai, Niina; Hytti, Maria; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu, 2022, Acta ophthalmologica. Abstract -
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
Bhattarai, Niina; Hytti, Maria; Reinisalo, Mika; Kaarniranta, Kai; Mysore, Yashavanthi; Kauppinen, Anu, 2022, Immunologic research, 70, 5, 678-687. A1 Journal article (refereed), original research -
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Tampio, Janne; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M, 2022, Molecular pharmaceutics, 19, 11, 3806-3819. A1 Journal article (refereed), original research -
Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells
Hytti, Maria; Ruuth, Johanna; Kanerva, Iiris; Bhattarai, Niina; Pedersen, Maria L; Nielsen, Carsten U; Kauppinen, Anu, 2022, Molecular and cellular biochemistry, 2023; 478, 1, 215-227. A1 Journal article (refereed), original research -
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2022, Inflammation research, 71, 7-8, 817-831. A2 Review article, Literature review, Systematic review -
Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells
Korhonen, Eveliina; Hytti, Maria; Piippo, Niina; Kaarniranta, Kai; Kauppinen, Anu, 2021, Experimental eye research, 209, 108687. A1 Journal article (refereed), original research -
Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration
Hytti, Maria; Korhonen, Eveliina; Hongisto, Heidi; Kaarniranta, Kai; Skottman, Heli; Kauppinen, Anu, 2021, International journal of molecular sciences, 22, 13, 6800. A1 Journal article (refereed), original research -
Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells
Bhattarai, Niina; Piippo, Niina; Ranta-aho, Sofia; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu, 2021, Antioxidants, 10, 1, 67. A1 Journal article (refereed), original research -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham; Adamopoulos, Iannis E; Adeli, Khosrow; Adolph, Timon E; Adornetto, Annagrazia; Aflaki, Elma; Agam, Galila; Agarwal, Anupam; Aggarwal, Bharat B; Agnello, Maria; Agostinis, Patrizia et al. [Incl. Haapasalo, Annakaisa; Leskelä, Stina; Kaarniranta, Kai; Kauppinen, Anu; Koskela, Ali], 2021, Autophagy, 17, 1, 1-382. A2 Review article, Literature review, Systematic review -
Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
Bhattarai, Niina; Korhonen, Eveliina; Mysore, Yashavanthi; Kaarniranta, Kai; Kauppinen, Anu, 2021, Cells, 10, 6, 1405. A1 Journal article (refereed), original research -
Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2021, Neurochemistry international, 150, 105186. A2 Review article, Literature review, Systematic review -
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2021, Inflammation research, 70, 10-12, 1043-1061. A2 Review article, Literature review, Systematic review -
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1[alpha] -/- Mouse Model Evoke Complement Component C5a Independent of C3
Sridevi Gurubaran, Iswariyaraja; Heloterä, Hanna; Marry, Stephen; Koskela, Ali; Hyttinen, Juha MT; Paterno, Jussi J; Urtti, Arto; Chen, Mei; Xu, Heping; Kauppinen, Anu; Kaarniranta, Kai, 2021, Biology, 10, 7, 622. A1 Journal article (refereed), original research -
Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous
Mysore, Yashavanthi; del Amo, Eva M; Loukovaara, Sirpa; Hagström, Marja; Urtti, Arto; Kauppinen, Anu, 2021, Scientific reports, 11, 1, 980. A1 Journal article (refereed), original research -
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu, 2021, International journal of molecular sciences, 22, 9, 4875. A1 Journal article (refereed), original research -
ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2020, Journal of molecular medicine: jmm, 98, 633-650. A2 Review article, Literature review, Systematic review -
Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2020, Cellular signalling, 75, 109771. A2 Review article, Literature review, Systematic review -
Introduction to the multi-author review on macular degeneration
Kauppinen, Anu, 2020, Cellular and molecular life sciences, 77, 5, 779-780. B1 Non-refereed journal articles -
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kaarniranta, Kai; Uusitalo, Hannu; Blasiak, Janusz; Felszeghy, Szabolcs; Kannan, Ram; Kauppinen, Anu; Salminen, Antero; Sinha, Debasish; Ferrington, Deborah, 2020, Progress in retinal and eye research, 78, 100858. A1 Journal article (refereed), original research -
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
Sridevi Gurubaran, Iswariyaraja; Viiri, Johanna; Koskela, Ali; Hyttinen, Juha M; Paterno, Jussi; Kis, Gréta; Antal, Miklós; Urtti, Arto; Kauppinen, Anu; Felszeghy, Szabolcs; Kaarniranta, Kai, 2020, International journal of molecular sciences, 21, 6, 1976. A1 Journal article (refereed), original research -
Only IL-1ß release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted
Korhonen, Eveliina; Piippo, Niina; Hytti, Maria; Hyttinen, Juha; Kaarniranta, Kai; Kauppinen, Anu, 2020, Faseb journal, 34, 5, 6437-6448. A1 Journal article (refereed), original research -
Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
Kauppinen, Anu; Kaarniranta, Kai; Salminen, Antero, 2020, Frontiers in immunology, 11, 384. A2 Review article, Literature review, Systematic review -
Theme issue on macular degeneration
Kauppinen, Anu, 2020, Springer. C2 Edited book, conference proceedings or special issue of a journal -
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Korhonen, Eveliina; Bisevac, Jovana; Hyttinen, Juha MT; Piippo, Niina; Hytti, Maria; Kaarniranta, Kai; Petrovski, Goran; Kauppinen, Anu, 2020, Investigative ophthalmology and visual science, 61, 4, 7. A1 Journal article (refereed), original research -
AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai, 2019, Journal of molecular medicine: jmm, 97, 8, 1049-1064. A2 Review article, Literature review, Systematic review -
Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
Hytti, Maria; Korhonen, Eveliina; Hyttinen, Juha M T; Roehrich, Heidi; Kaarniranta, Kai; Ferrington, Deborah A; Kauppinen, Anu, 2019, Oxidative medicine and cellular longevity, 2019, 1583656. A1 Journal article (refereed), original research -
Fatty acids and oxidized lipoproteins contribute to autophagy and innate immunity responses upon the degeneration of retinal pigment epithelium and development of age-related macular degeneration
Kaarniranta, Kai; Koskela, Ali; Felszeghy, Szabolcs; Kivinen, Niko; Salminen, Antero; Kauppinen, Aanu, 2019, Biochimie, 159, 49-54. A2 Review article, Literature review, Systematic review -
Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation
Szatmári-Tóth, M; Ilmarinen, T; Mikhailova, A; Skottman, H; Kauppinen, A; Kaarniranta, K; Kristóf, E; Lytvynchuk, L; Veréb, Z; Fésüs, L; Petrovski, G, 2019, International journal of molecular sciences, 20, 4, 926. A1 Journal article (refereed), original research -
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2019, Cellular and molecular life sciences, 76, 10, 1901-1918. A2 Review article, Literature review, Systematic review -
Life Style Intervention Improves Retinopathy Status - The Finnish Diabetes Prevention Study
Aro, A; Kauppinen, A; Kivinen, N; Selander, T; Kinnunen, K; Tuomilehto, J; Keinänen-Kiukaanniemi, S; Lindström, J; Uusitupa, M; Kaarniranta, K, 2019, Nutrients, 11, 7, 1691. A1 Journal article (refereed), original research -
SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1ß-stimulated human retinal pigment epithelial cells
Korhonen, E; Piippo, N; Hytti, M; Hyttinen, JMT; Kaarniranta, K; Kauppinen, A, 2019, Cytokine, 116, 70-77. A1 Journal article (refereed), original research -
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage
Zeiner, J; Loukovaara, S; Losenkova, K; Zuccarini, M; Korhonen, AM; Lehti, K; Kauppinen, A; Kaarniranta, K; Müller, CE; Jalkanen, S; Yegutkin, GG, 2019, Journal of molecular medicine: jmm, 97, 3, 341-354. A1 Journal article (refereed), original research -
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways
Marchesi, Nicoletta; Thongon, Natthakan; Pascale, Alessia; Provenzani, Alessandro; Koskela, Ali; Korhonen, Eveliina; Smedowski, Adrian; Govoni, Stefano; Kauppinen, Anu; Kaarniranta, Kai; Amadio, Marialaura, 2018, Oxidative medicine and cellular longevity, 2018, 4956080. A1 Journal article (refereed), original research -
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Piippo, N; Korhonen, E; Hytti, M; Skottman, H; Kinnunen, K; Josifovska, N; Petrovski, G; Kaarniranta, K; Kauppinen, A, 2018, Scientific reports, 8, 6720. A1 Journal article (refereed), original research -
Loss of NRF-2 and PGC-1[alpha] genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Felszeghy, S; Viiri, J; Paterno, JJ; Hyttinen, JMT; Koskela, A; Chen, M; Leinonen, H; Tanila, H; Kivinen, N; Koistinen, A; Toropainen, E; Amadio, M; Smedowski, A; Reinisalo, M; Winiarczyk, M; Mackiewicz, J; Mutikainen, M; Ruotsalainen, AK; Kettunen, M; Jokivarsi, K; et al [Incl Kaarniranta, K; Kauppinen, A; Kinnunen, K; Levonen, A-L; Salminen, A; Tavi, P-P; Urtti, A], 2018, Redox biology, 2019; 20, 1-12. A1 Journal article (refereed), original research -
Mechanistical retinal drug targets and challenges
Kaarniranta; Kai; Xu, Heping; Kauppinen, Anu, 2018, Advanced drug delivery reviews, 126, 177-184. A2 Review article, Literature review, Systematic review -
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, Antero; Kauppinen, Anu; Kaarniranta, Kai, 2018, Biogerontology, 19, 5, 325-329. A2 Review article, Literature review, Systematic review -
NLRP3-inflammasomiaktivaatio diabeettisessa retinopatiassa
Kauppinen, Anu, 2018, BestPractice: Diabetes ja sydänsairaudet, 6, Nro 21. Maaliskuu 2018. D1 Article in a trade journal -
Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy
Piippo, Niina; Korhonen, Eveliina; Hytti, Maria; Kinnunen, Kati; Kaarniranta, Kai; Kauppinen, Anu, 2018, Cellular physiology and biochemistry, 49, 1, 359-367. A1 Journal article (refereed), original research -
Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders.
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2018, International immunopharmacology, 61, 231-240. A2 Review article, Literature review, Systematic review -
The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2018, Cellular and molecular life sciences, 75, 17, 3099-3120. A2 Review article, Literature review, Systematic review -
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu, 2018, Ageing research reviews, 48, 1-10. A2 Review article, Literature review, Systematic review -
CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells
Hytti M, Andjelic S, Josifovska N, Piippo N, Korhonen E, Hawlina M, Kaarniranta K, Nevalainen TJ, Petrovski G, Parkkari T, Kauppinen A, 2017, Scientific reports, 7, 1, 16169. A1 Journal article (refereed), original research -
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells - Implications for age-related macular degeneration (AMD)
Hyttinen JMT, Blasiak J, Niittykoski M, Kinnunen K, Kauppinen A, Salminen A, Kaarniranta K, 2017, Ageing research reviews, 36, 64-77. A2 Review article, Literature review, Systematic review -
Hypoxia and inflammation in the release of VEGF and interleukins from human retinal pigment epithelial cells
Arjamaa Olli, Aaltonen Vesa, Piippo Niina, Csont Tamás, Petrovski Goran, Kaarniranta Kai, Kauppinen Anu, 2017, Graefes archive for clinical and experimental ophthalmology, 255, 9, 1757-1762. A1 Journal article (refereed), original research -
Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease
Salminen Antero, Kauppinen Anu, Kaarniranta Kai, 2017, Journal of neurochemistry, 140, 4, 536-549. A2 Review article, Literature review, Systematic review -
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
Salminen A, Kaarniranta K, Kauppinen A, 2017, Cellular signalling, 40, 10-21. A2 Review article, Literature review, Systematic review -
Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)
Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A, 2017, Journal of cell communication and signaling, 11, 3, 275-279. A1 Journal article (refereed), original research -
Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases
Kauppinen Anu, 2017, Fulop Tamas, Franceschi Claudio, Hirokawa Katsuiku, Pawelec Graham, Handbook of Immunosenescence : Basic Understanding and Clinical Implication, 1-20. A3 Book section, Chapters in research books -
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A, 2017, Acta ophthalmologica, 95, 8, 803-808. A1 Journal article (refereed), original research -
Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
Salminen Antero, Kaarniranta Kai, Kauppinen Anu, 2017, Ageing research reviews, 37, 79-93. A2 Review article, Literature review, Systematic review -
Silmänpohjan ikärappeuman patogeneesi - autofagian ja inflammasomien vuoropuhelua
Kivinen Niko, Koskela Ali, Kauppinen Anu, Kaarniranta kai, 2017, Duodecim, 133, 7, 641-646. A2 Review article, Literature review, Systematic review -
The Nobel Prized cellular target autophagy in eye diseases
Kaarniranta Kai, Petrovski Goran, Kauppinen Anu, 2017, Acta ophthalmologica, 95, 4, 335-336. B1 Non-refereed journal articles -
Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cell
Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A, 2017, Journal of nutritional biochemistry, 42, 37-42. A1 Journal article (refereed), original research -
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms
Salminen Antero, Kaarniranta Kai, Kauppinen Anu, 2016, Biogerontology, 17, 4, 655-680. A2 Review article, Literature review, Systematic review -
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Salminen Antero, Kauppinen Anu, Kaarniranta Kai, 2016, Cellular signalling, 28, 8, 887-895. A2 Review article, Literature review, Systematic review -
Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
Kivinen Niko, Felszeghy Szabolcs, Kinnunen Aino I, Setälä Niko, Aikio Mari, Kinnunen Kati, Sironen Reijo, Pihlajaniemi Taina, Kauppinen Anu, Kaarniranta Kai, 2016, Biogerontology, 17, 4, 749-761. A1 Journal article (refereed), original research -
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
Salminen Antero, Kaarniranta Kai, Kauppinen Anu, 2016, Ageing research reviews, 28, 15-26. A2 Review article, Literature review, Systematic review -
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration
Szatmári-Tóth M, Kristóf E, Veréb Z, Akhtar S, Facskó A, Fésus L, Kauppinen A, Kaarniranta K, Petrovski G, 2016, Cell death and disease, 7, 9, e2367. A1 Journal article (refereed), original research -
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai, 2016, Journal of molecular medicine: jmm, 2017; 95, 2, 123-131. A2 Review article, Literature review, Systematic review -
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
Salminen Antero, Kaarniranta Kai, Kauppinen Anu, 2016, Aging and disease, 7, 2, 180-200. A2 Review article, Literature review, Systematic review -
Inflammation and its role in age-related macular degeneration
Kauppinen Anu, Paterno Jussi J, Blasiak Janusz, Salminen Antero, Kaarniranta Kai, 2016, Cellular and molecular life sciences, 73, 9, 1765-1786. A2 Review article, Literature review, Systematic review -
Inhibition of BET bromodomains alleviates inflammation in human RPE cells
Hytti Maria, Tokarz P, Määttä E, Piippo Niina, Korhonen Eveliina, Suuronen T, Honkakoski Paavo, Kaarniranta Kai, Lahtela-Kakkonen Maija, Kauppinen Anu, 2016, Biochemical pharmacology, 110-111, 71-79. A1 Journal article (refereed), original research -
Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa
Trzeciecka Anna, Paterno J Jussi, Toropainen Elisa, Koskela Ali, Podracka Lucia, Korhonen Eveliina, Kauppinen Anu, Kaarniranta Kai, Smedowski Adrian, 2016, European journal of pharmacology, 788, 12-20. A1 Journal article (refereed), original research -
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
Salminen Antero, Kauppinen Anu, Kaarniranta Kai, 2015, Cellular and molecular life sciences, 72, 20, 3897-3914. A1 Journal article (refereed), original research -
Cytotoxicity assessment of porous silicon microparticles for ocular drug delivery
Korhonen Eveliina, Rönkkö Seppo, Hillebrand Satu, Riikonen Joakim, Xu Wujun, Järvinen Kristiina, Lehto Vesa-Pekka, Kauppinen Anu, 2015, European journal of pharmaceutics and biopharmaceutics, 2016; 100, 1-8. A1 Journal article (refereed), original research -
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
Hytti Maria, Piippo Niina, Korhonen Eveliina, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu, 2015, Scientific reports, 5, 17645 (2015). A1 Journal article (refereed), original research -
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Salminen Antero, Haapasalo Annakaisa, Kauppinen Anu, Kaarniranta Kai, Soininen Hilkka, Hiltunen Mikko, 2015, Progress in neurobiology, epub ahead of print 19 May 2015. A1 Journal article (refereed), original research -
Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
Hytti Maria, Piippo Niina, Salminen Antero, Honkakoski Paavo, Kaarniranta Kai, Kauppinen Anu, 2015, Experimental eye research, 132, 208-215. A1 Journal article (refereed), original research -
CB2 receptor as a potential target in age-related diseases
Kauppinen Anu, Nevalainen Tapio, Hytti Maria, Salminen Antero, Kaarniranta Kai, Parkkari Teija, 2014, Journal of biochemical and pharmacological research, 2, 1, 33-43. A2 Review article, Literature review, Systematic review -
Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures
Kinnunen Kati, Kauppinen Anu, Piippo Niina, Koistinen Arto, Toropainen Elisa, Kaarniranta Kai, 2014, Experimental eye research, 120, 82-89. A1 Journal article (refereed), original research -
Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells
Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A, 2014, Biochimica et biophysica acta: molecular cell research, 1843, 12, 3038-3046. A1 Journal article (refereed), original research -
Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration
Kaarniranta Kai, Machalinska Anna, Veréb Zoltán, Salminen Antero, Petrovski Goran, Kauppinen Anu, 2014, Current eye research, 2014, 1-8. A2 Review article, Literature review, Systematic review -
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu, 2014, Journal of molecular medicine: jmm, -. A2 Review article, Literature review, Systematic review -
Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells
Kivinen Niko, Hyttinen Juha MT, Viiri Johanna, Paterno Jussi, Felszheghy Szabolcs, Kauppinen Anu, Salminen Antero, Kaarniranta Kai, 2014, Journal of biochemical and pharmacological research, 2, 1, 1-7. A1 Journal article (refereed), original research -
Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity
Salminen A, Kauppinen A, Kaarniranta K, 2014, Irfan Rahman and Debasis Bagchi, Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions, 323-332. A3 Book section, Chapters in research books -
Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process
Salminen Antero, Kaarniranta Kai, Hiltunen Mikko, Kauppinen Anu, 2014, Cellular signalling, 26, 1598-1603. A2 Review article, Literature review, Systematic review -
Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process
Salminen Antero, Kauppinen Anu, Hiltunen Mikko, Kaarniranta Kai, 2014, Ageing research reviews, 16, 45-65. A2 Review article, Literature review, Systematic review -
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists
Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija, 2014, European journal of pharmaceutical sciences, 2015; 67, 85-96. A1 Journal article (refereed), original research -
Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy
Penttilä E, Hyttinen JMT, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppä J, Nuutinen J, Kaarniranta K, 2014, Clinical ophthalmology, 8, 799-805. A1 Journal article (refereed), original research -
Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders
Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A, 2013, Cellular signalling, 25, 1939-1948. A2 Review article, Literature review, Systematic review -
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G, 2013, Autophagy, 9, 7, 1-12. A2 Review article, Literature review, Systematic review -
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process
Salminen A, Kaarniranta K, Kauppinen A, 2013, Ageing research reviews, 12, 520-534. A2 Review article, Literature review, Systematic review -
Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization
Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K, 2013, International journal of biochemistry and cell biology, 45, 1457-1467. A2 Review article, Literature review, Systematic review -
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
Salminen A, Kaarniranta K, Kauppinen A, 2013, International journal of molecular sciences, 14, 3834-3859. A2 Review article, Literature review, Systematic review -
Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function
Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K, 2013, Cellular and molecular life sciences, -. A2 Review article, Literature review, Systematic review -
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M, 2013, Progress in neurobiology, 106-107, 33-54. A1 Journal article (refereed), original research -
Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling
Kauppinen A, Salminen A, Kaarniranta K, 2013, Inflammasome, 1, 2-14. A2 Review article, Literature review, Systematic review -
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration
Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K, 2013, International journal of molecular sciences, 14, 2, 2996-3010. A2 Review article, Literature review, Systematic review -
Oxidative DNA Damage and Proteostasis in Age-Related Macular Degeneration
Tokarz P, Kauppinen A, Kaarniranta K, Blasiak J, 2013, Journal of biochemical and pharmacological research, 1, 2, 106-113. A2 Review article, Literature review, Systematic review -
Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
Kaarniranta K, Kauppinen A, Blasiak J, Salminen A, 2012, Future medicinal chemistry, 4, 17, 2153-2161. A2 Review article, Literature review, Systematic review -
Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process
Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K, 2012, International journal of cell biology, 2012, ID 849541, 15 pages. A2 Review article, Literature review, Systematic review -
Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)
Salminen A, Kauppinen A, Kaarniranta K, 2012, Cellular signalling, 24, 835-845. A2 Review article, Literature review, Systematic review -
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A; Kaarniranta, K; Kauppinen, A, 2012, Aging, 4, 3, 166-175. A1 Journal article (refereed), original research -
Mitochondrial dysfunction and oxidative stress active inflammasomes: impact on the aging process and age-related diseases
Salminen A, Ojala J, Kaarniranta K, Kauppinen A, 2012, Cellular and molecular life sciences, 69, 2999-3013. A1 Journal article (refereed), original research -
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells - Implications for age-related macular degeneration (AMD)
Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K, 2012, Immunology letters, 147, 29-33. A1 Journal article (refereed), original research -
Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process
Salminen A, Kauppinen A, Kaarniranta K, 2012, Current opinion in clinical nutrition and metabolic care, 15, 23-28. A2 Review article, Literature review, Systematic review -
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
Paimela, T; Ryhänen, T; Kauppinen, A; Marttila, L; Salminen, A; Kaarniranta, K, 2012, Molecular vision, 18, 1189-1196. A1 Journal article (refereed), original research -
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
Jauhonen H-M, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K, 2011, Molecular vision, 17, 2311-2317. A1 Journal article (refereed), original research -
Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro
Viiri J, Jauhonen HM, Kauppinen A, Ryhänen T, Paimela T, Hyttinen J, Sorri I, Laihia JK, Leino L, Kaarniranta K, 2009, Molecular vision, 15, 1799-1805. A1 Journal article (refereed), original research -
Clusterin: A forgotten player in Alzheimer's disease
Nuutinen T, Suuronen T, Kauppinen A, Salminen A, 2009, Brain research reviews, 61, 89-104. A2 Review article, Literature review, Systematic review -
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J, 2009, Journal of neuroinflammation, 6, 41, [13 p.]. A2 Review article, Literature review, Systematic review -
Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T, 2009, Progress in neurobiology, 87, 181-194. A1 Journal article (refereed), original research -
Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells
Juntunen R, Liukko A, Taivainen A, Närvänen A, Durand G, Kauppinen A, Nieminen A, Rytkönen-Nissinen M, Saarelainen S, Maillère B, Virtanen T, Kinnunen T, 2009, Molecular immunology, 46, 3320-3327. A1 Journal article (refereed), original research -
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T, 2008, Ageing research reviews, 7, 83-105. A2 Review article, Literature review, Systematic review -
Amyloid-beta oligomers set fire to inflammasomes and induce Alzherimer's pathology
Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A, 2008, Journal of cellular and molecular medicine, 12, 6A, 2255-2262. A1 Journal article (refereed), original research -
Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity
Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T, 2008, Clinical and experimental allergy, 38, 374-381. A1 Journal article (refereed), original research -
Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues
Saarelainen SA, Kinnunen TT, Buhot C, Närvänen ATO, Kauppinen AK, Rytkönen-Nissinen MA, Maillere B, Virtanen TI, 2008, Immunology, 123, 358-366. A1 Journal article (refereed), original research -
Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K, 2008, Cellular and molecular life sciences, 65, 1049-1058. A2 Review article, Literature review, Systematic review -
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, 2008, Bioessays, 30, 939-942. A1 Journal article (refereed), original research -
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy
Kinnunen T, Jutila K, Kwok WW, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Närvänen A, Taivainen A, Virtanen T, 2007, Journal of allergy and clinical immunology, 119, 965-972. A1 Journal article (refereed), original research -
The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes
Immonen A, Kinnunen T, Sirven P, Taivainen A, Houitte D, Peräsaari J, Närvänen A, Saarelainen S, Rytkönen- Nissinen M, Maillere B, Virtanen T, 2007, Clinical and experimental allergy, 37, 939-947. A1 Journal article (refereed), original research -
Use of multiple peptides containing T cell epitopes is a feasible approach for peptide-based immunotherapy in Can f 1 allergy
Immonnen AK, Taivainen AH, Närvänen ATO, Kinnunen TT, Saarelainen SA, Rytkönen-Nissinen MA, Virtanen TI, 2007, Immunology, 120, 38-46. A1 Journal article (refereed), original research -
Lipocalin Allergen-Induced T Cell Response. Prospects for Peptide-Based Immunotherapy
Kauppinen A, 2006, Kuopio University Publications D. Medical Sciences. G5 Doctoral dissertation (article) -
Effects of short- and long-term ultraviolet B irradiation on the immune system of the common carp (Cyprinus carpio)
Markkula SE, Salo HM, Immonen AK, Jokinen EI, 2005, Photochemistry and photobiology, 81, 3, 595-602. A1 Journal article (refereed), original research -
Immunomodulatory potential of heteroclitic analogs of the dominant T-cell epitope of lipocalin allergen Bos d 2 on specific T cells
Kinnunen T, Kwock WW, Närvänen A, Rytkönen-Nissinen M, Immonen A, Saarelainen S, Taivainen A, Virtanen T, 2005, International immunology, 17, 12, 1573-1581. A1 Journal article (refereed), original research -
T cell epitope-containing peptides of the major dog allergen can f 1 as candidates for allergen immunotherapy
Immonen A, Farci S, Taivainen A, Partanen J, Pouvelle-Moratille S, Närvänen A, Kinnunen T, Saarelainen S, Rytkönen-Nissinen M, Maillere B, Virtanen T, 2005, Journal of immunology, 175, 6, 3614-3620. A1 Journal article (refereed), original research -
The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1
Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkönen-Nissinen M, Rautiainen J, Virtanen T, 2005, Clinical and experimental allergy, 35, 797-803. A1 Journal article (refereed), original research -
Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T, 2004, Clinical and experimental allergy, 34, 1576-1582. A1 Journal article (refereed), original research -
Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model
Immonen A, Saarelainen S, Rautiainen J, Rytkönen-Nissinen M, Kinnunen T, Mäntyjärvi R, Virtanen T, 2003, Clinical and experimental allergy, 33, 834-841. A1 Journal article (refereed), original research