Bioorganic chemistry

Research group

Research in the interface between organic and biological chemistry. Protein structure & function, biorefining and bioanalytical chemistry.

The research within the bioorganic chemistry research group concentrates on three main themes: 1) Elucidation of structure and function of proteins at atomic level by using X-ray crystallography and native mass spectrometry, 2) enzymatical and thermochemical biomass refining, and 3) bioanalytical chemistry, especially high-resolution mass spectrometry. The group has a state-of-the-art research infrastructure in use. The group is a member of the Finnish (FINStruct) and a pan-European Structural Biology Infrastructure (Instruct-ERIC; networks, and provides mass spectrometry services also via EU FT-ICR MS network (

Group description

Introducing image of the groupBioorganic chemistry

Research group portrayed in March 2019.



Allergen proteins, diagnostic and therapeutic antibodies, biomass refining enzymes (hydrolyses, polyphenol oxidases), metalloproteins.


Slow and fast pyrolysis, hydrothermal liquefaction, catalytic upgrading of bio-oils (hydrodeoxygenation, catalytic pyrolysis)


High-resolution mass spectrometry, native mass spectrometry, proteomics, metabolomics, complex mixture analysis (crude oil, bio-oils, dissolved organic matter, extracts, alcohol chemistry).



  • High-resolution mass spectrometry (12-T Bruker Solarix FT-ICR MS, Bruker timsTOF ion mobility MS; both systems with LC/GC)
  • Protein crystallography (Marresearch Mar 345 imaging plate, Nonius/Bruker FR591 rotating anode)
  • Thermochemical conversion (lab-scale micropyrolysis, Parr 4584 hydrothermal pressure reactor)
  • Protein production and characterization facilities (HPLC, DLS, SDS-PAGE, light microscopy, crystallization robot)
  • Bio-oil and complex mixture analytics (CHNOS, calorimetry, pH, TAN, KF titration, FT-IR, NMR)


For more information, please contact group PIs (contact details below).



Group members - UEF

Other group members

  • Yanning Dou
    Yanning Dou
  • Jie Guo
    Jie Guo
  • Timo Kröger
    Timo Kröger
  • Hanna Karvinen
    Hanna Karvinen

Cooperation partners