CAIDE - Cardiovascular Risk Factors, Aging and Dementia
Leaders
Principal Investigator: Miia Kivipelto
Scientific Coordinators: Alina Solomon, Tiia Ngandu, Jenni Kulmala
Field Coordinators: Mariagnese Barbera, Inna Lisko
CAIDE is a population-based cohort study initiated in 1998 to investigate the potential role of midlife modifiable risk and protective factors in the development of dementia.
It initially included 2000 people who participated in Finnish, mid-life, population-based surveys (The North Karelia project and FINMONICA studies, later FINRISK) between 1972 and 1987, in the Kuopio and Joensuu areas of Eastern Finland.
The study first follow-up was conducted in 1998 and the second in 2005-2008, an average of 21 and 28 years after the mid-life examination, respectively. Between 2006 and 2009, a secondo cohort was recruited about 20 years after their mid-life examination (1987-1992) for their first follow-up.
The findings from the CAIDE study have, so far, provided essential knowledge on several risk and protective factors for dementia, including interactions between genetics and lifestyle. Based on these findings, the CAIDE Dementia Risk Score, the first tool to predict the risk of late-life dementia based on lifestyle and cardiovascular risk factors at mid-life, was developed (Kivipelto et al., The Lancet Neurology, 2006). Its current main application is as a research tool; for example, it was used to select older adults at increased risk of cognitive decline as participants in the FINGER trial.
The third follow-up (CAIDE 85+) is currently ongoing in Kuopio and Joensuu, almost 50 years after the first examination.
Study Registration Number: NCT03938727.
Funding: Juho Vainio Foundation, Sigrid Juselius Foundation, Academy of Finland.
Cooperation
Leaders
Professors
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Tiina Laatikainen
ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Hilkka Soininen
Professor, EmeritaInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Senior Researchers
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Alina Solomon
ProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Elisa Tiilikainen
Associate ProfessorDepartment of Social Sciences, Faculty of Social Sciences and Business Studies -
Merja Hallikainen
Visiting ResearcherInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences
Post-doctoral Researchers
Doctoral Researchers
Research Nurses
Other group members
Publications
18 items-
Change in CAIDE Dementia Risk Score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis
Stephen, Ruth; Ngandu, Tiia; Liu, Yawu; Peltonen, Markku; Antikainen, Riitta; Kemppainen, Nina; Laatikainen, Tiina; Lötjönen, Jyrki; Rinne, Juha; Strandberg, Timo; Tuomilehto, Jaakko; Vanninen, Ritva; Soininen, Hilkka; Kivipelto, Miia; Solomon, Alina. 2021. Journals of gerontology series a: biological sciences and medical sciences. 76: 1407-1414 -
Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol
Barbera, Mariagnese; Kulmala, Jenni; Lisko, Inna; Pietilä, Eija; Rosenberg, Anna; Hallikainen, Ilona; Hallikainen, Merja; Laatikainen, Tiina; Lehtisalo, Jenni; Neuvonen, Elisa; Rusanen, Minna; Soininen, Hilkka; Tuomilehto, Jaakko; Ngandu, Tiia; Solomon, Alina; Kivipelto, Miia. 2020. Bmc geriatrics. 20: 238 -
Long-term dementia risk prediction by the LIBRA score: a 30-year follow-up of the CAIDE study
Deckers, K; Barbera, M; Köhler, S; Ngandu, T; van Boxtel, M; Rusanen, M; Laatikainen, T; Verhey, F; Soininen, H; Kivipelto, M; Solomon, A. 2019. International journal of geriatric psychiatry. 2020; 35: 195-203 -
Midlife improvements in financial situation are associated with a reduced dementia risk later in life: The CAIDE 30-Year Study
Sindi, S; Darin-Mattsson, A; Kåreholt, I; Kulmala, J; Ngandu, T; Laatikainen, T; Soininen, H; Kivipelto, M. 2019. International psychogeriatrics. [Published online 25 November 2019]: 1-8 -
CAIDE dementia risk score, Alzheimer and cerebrovascular pathology: a population-based autopsy study
Hooshmand, B; Polvikoski, T; Kivipelto, M; Tanskanen, M; Myllykangas, L; Mäkelä, M; Oinas, M; Paetau, A; Solomon, A. 2018. Journal of internal medicine. 283: 597-603 -
Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition
Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, Laatikainen T, Paajanen T, Hänninen T, Strandberg T, Antikainen R, Tuomilehto J, Keinänen Kiukaanniemi S, Vanninen R, Helisalmi S, Levälahti E, Kivipelto M, Soininen H, Solomon A. 2017. Journal of Alzheimer's disease. 59: 695-705 -
CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia.
Enache D, Solomon A, Cavallin L, Kåreholt I, Kramberger MG, Aarsland D, Kivipelto M, Eriksdotter M, Winblad B, Jelic V. 2016. Neurobiology of aging. 42: 124-131 -
Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study
Pekkala Timo, Hall Anette, Lötjönen Jyrki, Mattila Jussi, Soininen Hilkka, Ngandu Tiia, Laatikainen Tiina, Kivipelto Miia, Solomon Alina. 2016. Journal of Alzheimer's disease. 2017; 55: 1055-1067 -
Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study
Imtiaz Bushra, Tolppanen Anna-Maija, Solomon Alina, Soininen Hilkka, Kivipelto Miia. 2016. Journal of Alzheimer's disease. 2017; 56: 453-458 -
Midlife work-related stress increases dementia risk in later life: the CAIDE 30-year study
Sindi Shireen, Hagman Göran, Håkansson Krister, Kulmala Jenni, Nilsen Charlotta, Kåreholt Ingemar, Soininen Hilkka, Solomon Alina, Kivipelto Miia. 2016. Journals of gerontology series b: psychological sciences and social sciences. 2017; 72: 1044-1053