EDCMET
Project
Finished 01.01.2019 - 30.06.2024
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
School of Pharmacy, Faculty of Health Sciences
Funders
Main funder
European Comission
Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways
Leaders
EDCMET researchers at the General Assembly meeting in Berlin.
The EDCMET project connects experts in various research fields, including systems toxicologists, experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills and ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. Together we aim to develop novel validated test methods and models to assess the metabolic effects of endocrine disrupting compounds and to identify molecular initiating events linked to adverse outcomes.
Cooperation
Leaders
Professors
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Paavo Honkakoski
ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Jorma Palvimo
ProfessorInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Jaana Rysä
ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Antti Poso
ProfessorSchool of Pharmacy, Faculty of Health Sciences
Senior Researchers
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Vittorio Fortino
Academy Research FellowInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences -
Jenni Küblbeck
Senior ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Olli Kärkkäinen
Senior ResearcherSchool of Pharmacy, Faculty of Health Sciences
Post-doctoral Researchers
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Raghavendra Mysore
Project ResearcherSchool of Pharmacy, Faculty of Health Sciences -
Henriikka Hakomäki
Postdoctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Doctoral Researchers
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Sini Pitkänen
Doctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Arindam Ghosh
Doctoral ResearcherInstitute of Biomedicine, School of Medicine, Faculty of Health Sciences
Supporting Staff
Publications
9 items-
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia
Itkonen, Anna; Hakkola, Jukka; Rysä, Jaana. 2023. Archives of toxicology. 97: 2861-2877 A2 Review article, Literature review, Systematic review -
Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers
Palaniswamy, Saranya; Abass, Khaled; Rysä, Jaana; Grimalt, Joan O; Odland, Jon Øyvind; Rautio, Arja; Järvelin, Marjo Riitta. 2023. Frontiers in public health. 11: . 1248609 A1 Journal article (refereed), original research -
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka. 2023. Molecular metabolism. 76: A1 Journal article (refereed), original research -
EDTox: an R Shiny application to predict the endocrine disruption potential of compounds
Sakhteman, Amirhossein; Ghosh, Arindam; Fortino, Vittorio. 2022. Bioinformatics. 38: 2066-2069 A1 Journal article (refereed), original research -
Hormonihäirikköjä lautasella?
Küblbeck, Jenni; Pitkänen, Sini. 2022. Kehittyvä Elintarvike. 33: 16-17 D1 Article in a trade journal -
Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension
Rahunen, Roosa; Kummu, Outi; Koivukangas, Vesa; Hautajärvi, Heidi; Hakkola, Jukka; Rysä, Jaana; Hukkanen, Janne. 2022. Journal of the american heart association: Cardiovascular and cerebrovascular disease. 11: . e023492 A1 Journal article (refereed), original research -
A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity
Sakhteman, A; Failli, M; Kublbeck, J; Levonen, AL; Fortino, V. 2021. Environment international. 156: 106751 A1 Journal article (refereed), original research -
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
Küblbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo. 2020. Cells. 9: 2306 A2 Review article, Literature review, Systematic review -
The EDCMET project: Metabolic effects of endocrine disruptors
Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeunin, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. International journal of molecular sciences. 21: 3021 A1 Journal article (refereed), original research