
I study the effects of different exposures, e.g. alcohol and drugs, to the metabolic processes in the body using metabolomics methods. My coal is to increase our understanding of disease processes to identify novel biomarkers of exposure and to identify new targets for treatment.
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Publications
90/90 items-
Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2025, Basic and clinical pharmacology and toxicology, 136, 5, 1-11. A1 Journal article (refereed), original research -
Bipolar Disorder and Poisoning due to Medicines or Illegal Substances
Niskanen, Mikko; Kärkkäinen, Olli; Taipale, Heidi; Lieslehto, Johannes; Tiihonen, Jari; Hamina, Aleksi, 2025, Acta psychiatrica scandinavica, 152, 4, 299-307. A1 Journal article (refereed), original research -
Blueprint of the distinct metabolite profiles of healthy pig heart chambers
Haikonen, Retu; Meuronen, Topi; Koistinen, Ville; Kärkkäinen, Olli; Tuomainen, Tomi; Solano-Aguilar, Gloria I; Urban, Joseph F; Lehtonen, Marko; Tavi, Pasi; Hanhineva, Kati, 2025, Journal of molecular and cellular cardiology plus, 13, 100462. A1 Journal article (refereed), original research -
Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes
Juvonen, Risto O; Postila, Pekka A; Singh, Pankaj Kumar; Huuskonen, Juhani; Timonen, Juri; Fashe, Muluneh; Hussain, Rasikh; Aqip, Zaeema; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T, 2025, European journal of pharmaceutical sciences, 213, 107249. A1 Journal article (refereed), original research -
Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention
Amadieu, Camille; Ahmed, Hany; Leclercq, Sophie; Koistinen, Ville; Leyrolle, Quentin; Stärkel, Peter; Bindels, Laure B; Layé, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli; De Timary, Philippe; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Clinical nutrition ESPEN, 66, 361-371. A1 Journal article (refereed), original research -
Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells
Wallén, E.; Rämö, K.; Vehviläinen, J.; Sokka, J.; Lehtonen, M.; Otonkoski, T.; Trokovic, R.; Auvinen, P.; Kärkkäinen, O.; Kaminen-Ahola, N, 2025, Disease models and mechanisms, 18, 6, dmm052150. A1 Journal article (refereed), original research -
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health
Neyrinck, Audrey M; Ahmed, Hany; Leyrolle, Quentin; Leclercq, Sophie; Amadieu, Camille; Meuronen, Topi; Layé, Sophie; Cani, Patrice D; Kärkkäinen, Olli; Bindels, Laure B; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Scientific reports, 15, 1, 15455. A1 Journal article (refereed), original research -
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research -
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders
Luykx, Jurjen J; Corbeil, Olivier; Kärkkäinen, Olli; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari; Taipale, Heidi, 2025, Molecular psychiatry, 30, 10, 4859-4867. A1 Journal article (refereed), original research -
Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy
Itkonen, Anna; Kärkkäinen, Olli; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2025, Metabolomics, 21, 5, 123. A1 Journal article (refereed), original research