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Olli Kärkkäinen

Olli Kärkkäinen

Senior Researcher

School of Pharmacy, Faculty of Health Sciences

[email protected]

Information Publications

I study the effects of different exposures, e.g. alcohol and drugs, to the metabolic processes in the body using metabolomics methods. My coal is to increase our understanding of disease processes to identify novel biomarkers of exposure and to identify new targets for treatment.

Research groups

Kuopio Birth Cohort (KuBiCo) 01.07.2012 -
Toxicology Research Group 01.03.2014 -

Projects

EDCMET Finished 01.01.2019 - 30.06.2024

Keywords

alcohol drugs metabolomics pharmacology pharmacy toxicology

Publications

90/90 items

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2025, Basic and clinical pharmacology and toxicology, 136, 5, 1-11. A1 Journal article (refereed), original research
Bipolar Disorder and Poisoning due to Medicines or Illegal Substances
Niskanen, Mikko; Kärkkäinen, Olli; Taipale, Heidi; Lieslehto, Johannes; Tiihonen, Jari; Hamina, Aleksi, 2025, Acta psychiatrica scandinavica, 152, 4, 299-307. A1 Journal article (refereed), original research
Blueprint of the distinct metabolite profiles of healthy pig heart chambers
Haikonen, Retu; Meuronen, Topi; Koistinen, Ville; Kärkkäinen, Olli; Tuomainen, Tomi; Solano-Aguilar, Gloria I; Urban, Joseph F; Lehtonen, Marko; Tavi, Pasi; Hanhineva, Kati, 2025, Journal of molecular and cellular cardiology plus, 13, 100462. A1 Journal article (refereed), original research
Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes
Juvonen, Risto O; Postila, Pekka A; Singh, Pankaj Kumar; Huuskonen, Juhani; Timonen, Juri; Fashe, Muluneh; Hussain, Rasikh; Aqip, Zaeema; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T, 2025, European journal of pharmaceutical sciences, 213, 107249. A1 Journal article (refereed), original research
Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention
Amadieu, Camille; Ahmed, Hany; Leclercq, Sophie; Koistinen, Ville; Leyrolle, Quentin; Stärkel, Peter; Bindels, Laure B; Layé, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli; De Timary, Philippe; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Clinical nutrition ESPEN, 66, 361-371. A1 Journal article (refereed), original research
Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells
Wallén, E.; Rämö, K.; Vehviläinen, J.; Sokka, J.; Lehtonen, M.; Otonkoski, T.; Trokovic, R.; Auvinen, P.; Kärkkäinen, O.; Kaminen-Ahola, N, 2025, Disease models and mechanisms, 18, 6, dmm052150. A1 Journal article (refereed), original research
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health
Neyrinck, Audrey M; Ahmed, Hany; Leyrolle, Quentin; Leclercq, Sophie; Amadieu, Camille; Meuronen, Topi; Layé, Sophie; Cani, Patrice D; Kärkkäinen, Olli; Bindels, Laure B; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Scientific reports, 15, 1, 15455. A1 Journal article (refereed), original research
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders
Luykx, Jurjen J; Corbeil, Olivier; Kärkkäinen, Olli; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari; Taipale, Heidi, 2025, Molecular psychiatry, 30, 10, 4859-4867. A1 Journal article (refereed), original research
Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy
Itkonen, Anna; Kärkkäinen, Olli; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2025, Metabolomics, 21, 5, 123. A1 Journal article (refereed), original research
Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine
Masvosva, Wadzanai; Lehtonen, Marko; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Rysä, Jaana; Kok, Eloise; Kärkkäinen, Olli, 2025, Addiction biology, 30, 6, e70064. A1 Journal article (refereed), original research
Metabolic profiles of meconium in preeclamptic and normotensive pregnancies
Toivonen, Elli; Sikkinen, Jutta; Salonen, Anne; Kärkkäinen, Olli; Koistinen, Ville; Klåvus, Anton; Meuronen, Topi; Heini, Tuomas; Maltseva, Arina; Niku, Mikael; Jääskeläinen, Tiina; Laivuori, Hannele, 2025, Metabolomics, 21, 1, 21. A1 Journal article (refereed), original research
On Challenges of Studying the Complex Role of Bile Acids in Alcohol-Related Liver Disease
Stärkel, Peter; Kärkkäinen, Olli, 2025, Liver international, 45, 8, e70222. B1 Non-refereed journal articles
Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study
Puhakka, Eemeli; Ahmed, Hany; Haikonen, Retu; Leclercq, Sophie; Hanhineva, Kati; Maccioni, Luca; Amadieu, Camille; Lehtonen, Marko; Männistö, Ville; Rysä, Jaana; Stärkel, Peter; Kärkkäinen, Olli, 2025, Liver international, 45, 6, 1-11. A1 Journal article (refereed), original research
Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder
Kärkkäinen, Olli; Tolmunen, Tommi; Kivimäki, Petri; Kurkinen, Karoliina; Ali-Sisto, Toni; Mäntyselkä, Pekka; Valkonen-Korhonen, Minna; Koivumaa-Honkanen, Heli; Honkalampi, Kirsi; Ruusunen, Anu; Velagapudi, Vidya; Lehto, Soili M, 2024, Alcohol, 120, 161-167. A1 Journal article (refereed), original research
Alkoholi (etyylialkoholi, etanoli)
Korpi, Esa R; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 569-571. D2 Article in a professional book (incl. an introduction by the editor)
Alkoholien toksikokinetiikka
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1313-1314. D2 Article in a professional book (incl. an introduction by the editor)
Alkoholimyrkytyskuolemat ja alkoholille altistuminen
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1310-1313. D2 Article in a professional book (incl. an introduction by the editor)
Alkoholin akuutit vaikutukset
Korpi, Esa R; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 574-578. D2 Article in a professional book (incl. an introduction by the editor)
Alkoholin farmakokinetiikka
Korpi, Esa R; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 571-574. D2 Article in a professional book (incl. an introduction by the editor)
Alkoholitoleranssi ja vieroitusoireet
Korpi, Esa R; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 579-580. D2 Article in a professional book (incl. an introduction by the editor)
An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence
Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili M; Luoma, Ilona; Kraav, Siiri-Liisi; Kivimäki, Petri; Therman, Sebastian; Tolmunen, Tommi, 2024, Translational psychiatry, 14, 1, 466. A1 Journal article (refereed), original research
Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight
Masalin, Senja; Klåvus, Anton; Rönö, Kristiina; Koistinen, Heikki A; Koistinen, Ville; Kärkkäinen, Olli; Jääskeläinen, Tiina J; Klemetti, Miira M, 2024, Diabetologia, 67, 11, 2539-2554. A1 Journal article (refereed), original research
Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder
Zillich, Lea; Cetin, Metin; Hummel, Elisabeth M; Poisel, Eric; Fries, Gabriel R; Frank, Josef; Streit, Fabian; Foo, Jerome C; Sirignano, Lea; Friske, Marion M; Lenz, Bernd; Hoffmann, Sabine; Adorjan, Kristina; Kiefer, Falk; Bakalkin, Georgy; Hansson, Anita C; Lohoff, Falk W; Kärkkäinen, Olli; Kok, Eloise; Karhunen, Pekka J; Sutherland, Greg T; Walss‐Bass, Consuelo; Spanagel, Rainer; Rietschel, Marcella; Moser, Dirk A; Witt, Stephanie H, 2024, Alcohol, clinical & experimental research, 48, 2, 250-259. A1 Journal article (refereed), original research
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Leclercq, Sophie; Ahmed, Hany; Amadieu, Camille; Petit, Géraldine; Koistinen, Ville; Leyrolle, Quentin; Poncin, Marie; Stärkel, Peter; Kok, Eloise; Karhunen, Pekka J; de Timary, Philippe; Laye, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli K; Hanhineva, Kati; Delzenne, Nathalie, 2024, eLife, 13, RP96937. A1 Journal article (refereed), original research
Etanoli ja sikiö
Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1322-1323. D2 Article in a professional book (incl. an introduction by the editor)
Etanolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1315. D2 Article in a professional book (incl. an introduction by the editor)
Etanolin karsinogeeninen vaikutus
Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1321. D2 Article in a professional book (incl. an introduction by the editor)
Etanolin krooniset haittavaikutukset
Korpi, Esa R.; Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1318-1321. D2 Article in a professional book (incl. an introduction by the editor)
Etyleeniglykolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1317. D2 Article in a professional book (incl. an introduction by the editor)
Metanolimyrkytys
Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1315-1316. D2 Article in a professional book (incl. an introduction by the editor)
Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies
Voutilainen, Taija; Keski-Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2024, Basic and clinical pharmacology and toxicology, 134, 4, 543-555. A1 Journal article (refereed), original research
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives
Couacault, Pauline; Avella, Dennisse; Londoño-Osorio, Sara; Lorenzo, Ana S; Gradillas, Ana; Kärkkäinen, Olli; Want, Elizabeth; Witting, Michael, 2024, Analytical science advances, 5, 5-6, e2400002. A2 Review article, Literature review, Systematic review
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
Husso, Aleksi; Pessa-Morikawa, Tiina; Koistinen, Ville Mikael; Kärkkäinen, Olli; Kwon, Hyuk Nam; Lahti, Leo; Iivanainen, Antti; Hanhineva, Kati; Niku, Mikael, 2023, Bmc biology, 21, 1, 207. A1 Journal article (refereed), original research
Linking Hypothermia and Altered Metabolism with TrkB Activation
Alitalo, Okko; González-Hernández, Gemma; Rosenholm, Marko; Kohtala, Piia; Matsui, Nobuaki; Müller, Heidi Kaastrup; Theilmann, Wiebke; Klein, Anders; Kärkkäinen, Olli; Rozov, Stanislav; Rantamäki, Tomi; Kohtala, Samuel, 2023, Acs chemical neuroscience, 14, 17, 3212-3225. A1 Journal article (refereed), original research
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka, 2023, Molecular metabolism, 76, 101779. A1 Journal article (refereed), original research
The associations between metabolic profiles and sexual and physical abuse in depressed adolescent psychiatric outpatients: an exploratory pilot study
Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili M; Luoma, Ilona; Kraav, Siiri-Liisi; Kivimäki, Petri; Nieminen, Anni I; Sarnola, Katriina; Therman, Sebastian; Tolmunen, Tommi, 2023, European journal of psychotraumatology, 14, 1, 2191396. A1 Journal article (refereed), original research
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature
Koistinen, Ville; Kärkkäinen, Olli; Keski-Rahkonen, Pekka; Tsugawa, Hiroshi; Scalbert, Augustin; Arita, Masanori; Wishart, David; Hanhineva, Kati, 2023, Nature metabolism, 5, 351-354. B1 Non-refereed journal articles
Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice
Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O, 2023, Journal of nutrition and metabolism, 2023, 5599789. A1 Journal article (refereed), original research
Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease
Haikonen, Retu; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati, 2022, Trends in endocrinology and metabolism, 33, 7, 463-480. A2 Review article, Literature review, Systematic review
Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field
Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati, 2022, Nature metabolism, 4, 4, 406-406. B1 Non-refereed journal articles
Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta
Pessa-Morikawa, Tiina; Husso, Aleksi; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati; Iivanainen, Antti; Niku, Mikael, 2022, Bmc microbiology, 22, 1, 46. A1 Journal article (refereed), original research
Microbiota-derived metabolites as drivers of gut–brain communication
Ahmed, Hany; Leyrolle, Quentin; Koistinen, Ville; Kärkkäinen, Olli; Layé, Sophie; Delzenne, Nathalie; Hanhineva, Kati, 2022, Gut microbes, 14, 1, e2102878. A2 Review article, Literature review, Systematic review
No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Heinonen, Seppo; Hanhineva, Kati; Laivuori, Hannele, 2022, Pregnancy hypertension, 28, 74-80. A1 Journal article (refereed), original research
Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies
Voutilainen, Taija; Rysä, Jaana; Keski‐Nisula, Leea; Kärkkäinen, Olli, 2022, Alcoholism-clinical and experimental research, 46, 5, 797-808. A1 Journal article (refereed), original research
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele, 2021, Metabolomics, 17, 2, 20. A1 Journal article (refereed), original research
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise, 2021, Addiction biology, 26, 6, e13035. A1 Journal article (refereed), original research
Comparison of the level of allostatic load between patients with major depression and the general population
Honkalampi, Kirsi; Virtanen, Marianna; Hintsa, Taina; Ruusunen, Anu; Mäntyselkä, Pekka; Ali-Sisto, Toni; Kärkkäinen, Olli; Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna; Panayiotou, Georgia; Lehto, Soili M, 2021, Journal of psychosomatic research, 143, 110389. A1 Journal article (refereed), original research
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder
Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo, 2021, Alcoholism-clinical and experimental research, 45, 11, 2207-2216. A1 Journal article (refereed), original research
FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study
Meuronen, Topi; Lankinen, Maria A.; Kärkkäinen, Olli; Laakso, Markku; Pihlajamäki, Jussi; Hanhineva, Kati; Schwab, Ursula, 2021, European journal of nutrition, 2022; 61, 2, 1109-1120. A1 Journal article (refereed), original research
Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome
Herrala, Maria; Turunen, Soile; Hanhineva, Kati; Lehtonen, Marko; Mikkonen, Jopi J. W.; Seitsalo, Hubertus; Lappalainen, Reijo; Tjäderhane, Leo; Niemelä, Raija K.; Salo, Tuula; Myllymaa, Sami; Kullaa, Arja M.; Kärkkäinen, Olli, 2021, Metabolites, 11, 9, 595. A1 Journal article (refereed), original research
Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
Leyrolle, Quentin; Cserjesi, Renata; Demeure, Romane; Neyrinck, Audrey M.; Amadieu, Camille; Rodriguez, Julie; Kärkkäinen, Olli; Hanhineva, Kati; Paquot, Nicolas; Cnop, Miriam; Cani, Patrice D.; Thissen, Jean-Paul; Bindels, Laure B.; Klein, Olivier; Luminet, Olivier; Delzenne, Nathalie M., 2021, Nutrients, 2022; 14, 1, 147. A1 Journal article (refereed), original research
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A1
Juvonen, Risto O; Jokinen, Elmeri M; Huuskonen, Juhani; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T, 2021, Xenobiotica, 51, 11, 1207-1216. A1 Journal article (refereed), original research
One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study
Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili M; Luoma, Ilona; Kraav, Siiri-Liisi; Nieminen, Anni I; Kivimäki, Petri; Therman, Sebastian; Tolmunen, Tommi, 2021, Journal of affective disorders reports, 6, 100261. A1 Journal article (refereed), original research
Response to Letter by Benson et al. on 'Hangover and the Effects of L-Cysteine'
Eriksson, CJ Peter; Metsälä, Markus; Möykkynen, Tommi; Mäkisalo, Heikki; Kärkkäinen, Olli; Palmén, Maria; Salminen, Joonas E; Kauhanen, Jussi, 2021, Alcohol and alcoholism, 56, 5, 630-631. B1 Non-refereed journal articles
Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients
Leyrolle, Quentin; Cserjesi, Renata; Mulders, Maria DGH; Zamariola, Giorgia; Hiel, Sophie; Gianfrancesco, Marco A; Rodriguez, Julie; Portheault, Daphnée; Amadieu, Camille; Leclercq, Sophie; Bindels, Laure B; Neyrinck, Audrey M; Cani, Patrice D; Karkkainen, Olli; Haninheva, Kati; Lanthier, Nicolas; Trefois, Pierre; Paquot, Nicolas; Cnop, Miriam; Luminet, Olivier et al., 2021, Clinical nutrition, 40, 4, 2034-2044. A1 Journal article (refereed), original research
"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling
Klåvus, Anton; Kokla, Marietta; Noerman, Stefania; Koistinen, Ville M; Tuomainen, Marjo; Zarei, Iman; Meuronen, Topi; Häkkinen, Merja R; Rummukainen, Soile; Farizah Babu, Ambrin; Sallinen, Taisa; Kärkkäinen, Olli; Paananen, Jussi; Broadhurst, David; Brunius, Carl; Hanhineva, Kati, 2020, Metabolites, 10, 4, 135. A1 Journal article (refereed), original research
Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles
Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia, 2020, Cancers, 12, 11, 3292. A1 Journal article (refereed), original research
Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up
Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana, 2020, Alcoholism-clinical and experimental research, 44, 12, 2457-2467. A1 Journal article (refereed), original research
In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species
Juvonen, RO; Pentikäinen, O; Huuskonen, J; Timonen, J; Kärkkäinen, O; Heikkinen, A; Fashe, M; Raunio, H, 2020, Xenobiotica, 50, 8, 885-893. A1 Journal article (refereed), original research
L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety
Eriksson, CJP; Metsälä, M; Möykkynen, T; Mäkisalo, H; Kärkkäinen, O; Palmén, M; Salminen, JE; Kauhanen, J, 2020, Alcohol and alcoholism, 55, 6, 660-666. A1 Journal article (refereed), original research
Metabolome of canine and human saliva: a non-targeted metabolomics study
Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati, 2020, Metabolomics, 16, 9, 90. A1 Journal article (refereed), original research
Metabolomics analysis of plasma and adipose tissue samples from mice orally administered with polydextrose and correlations with cecal microbiota
Saarinen, Markku Tapani; Kärkkäinen, Olli; Hanhineva, Kati; Tiihonen, Kirsti; Hibberd, Ashley; Mäkelä, Kari Antero; Raza, Ghulam Shere; Herzig, Karl-Heinz; Anglenius, Heli, 2020, Scientific reports, 10, 1, 21577. A1 Journal article (refereed), original research
Changes in the Human Metabolome Associated With Alcohol Use: A Review
Voutilainen, T; Kärkkäinen, O, 2019, Alcohol and alcoholism, 54, 3, 225-234. A2 Review article, Literature review, Systematic review
Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation
Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K, 2019, Microbiome, 7, 103. A1 Journal article (refereed), original research
Effects of Long-term adolescent alcohol consumption on white matter integrity and their correlations with metabolic alterations
Shen, Qin; Heikkinen, Noora; Kärkkäinen, Olli; Gröhn, Heidi; Könönen, Mervi; Liu, Yawu; Kaarre, Outi; Zhang, Zishu; Tan, Changlian; Tolmunen, Tommi; Vanninen, Ritva, 2019, Psychiatry research: neuroimaging, 294, 111003. A1 Journal article (refereed), original research
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
Juvonen, Risto O; Heikkinen, Aki T; Kärkkäinen, Olli; Jehangir, Rabia; Huuskonen, Juhani; Troberg, Johanna; Raunio, Hannu; Pentikäinen, Olli T; Finel, Moshe, 2019, European journal of pharmaceutical sciences, 141, 105118. A1 Journal article (refereed), original research
Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study
Laukkanen, V; Kärkkäinen, O; Kautiainen, H; Tiihonen, J; Storvik, M, 2019, Psychiatry research: neuroimaging, 287, 63-69. A1 Journal article (refereed), original research
Metabolic signature of extracellular vesicles depends on the cell culture conditions
Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M, 2019, Journal of extracellular vesicles, 8, 1, 1596669. A1 Journal article (refereed), original research
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K, 2019, American journal of clinical nutrition, 110, 5, 1108-1118. A1 Journal article (refereed), original research
Repeated Transcranial Magnetic Stimulation-Induced Motor Evoked Potentials Correlate With the Subject-Specific Serum Metabolic Profile of Creatine
Kallioniemi, E; Kärkkäinen, O; Määttä, S; Könönen, M; Kivimäki, P; Kaarre, O; Velagapudi, V; Kekkonen, V; Lehto, SM; Laukkanen, E; Tolmunen, T, 2019, Journal of clinical neurophysiology, 36, 3, 229-235. A1 Journal article (refereed), original research
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC, 2018, Scientific reports, 8, 14616. A1 Journal article (refereed), original research
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T, 2018, European journal of obstetrics and gynecology and reproductive biology, 223, 79-84. A1 Journal article (refereed), original research
Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults
Heikkinen, N; Kärkkäinen, O; Laukkanen, E; Kekkonen, V; Kaarre, O; Kivimäki, P; Könönen, M; Velagapudi, V; Nandania, J; Lehto, SM; Niskanen, E; Vanninen, R; Tolmunen, T, 2018, Alcohol, 75, 89-97. A1 Journal article (refereed), original research
Decreased serum total cholesterol is associated with a history of childhood physical violence in depressed outpatients
Kraav, SL; Tolmunen, T; Kärkkäinen, O; Ruusunen, A; Viinamäki, H; Mäntyselkä, P; Koivumaa-Honkanen, H; Valkonen-Korhonen, M; Honkalampi, K; Herzig, KH; Lehto, SM, 2018, Psychiatry research, 2019; 272, 326-333. A1 Journal article (refereed), original research
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K, 2018, American journal of clinical nutrition, 108, 5, 971-979. A1 Journal article (refereed), original research
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T, 2018, Brain behavior and immunity, 73, 670-681. A1 Journal article (refereed), original research
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi, 2018, Cardiovascular research, 2019; 115, 1, 107-118. A1 Journal article (refereed), original research
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK, 2018, Molecular nutrition and food research, 2019; 63, 5, 1800605. A1 Journal article (refereed), original research
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati, 2018, Scientific reports, 8, 13036. A1 Journal article (refereed), original research
Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2016, Alcohol, 52, 63-70. A1 Journal article (refereed), original research
Post-Mortem Brains of Alcoholics: Changes in the Glutamatergic, Serotonergic, Endocannabinoid and Neuroactive Steroid Systems
Kärkkäinen Olli, 2016, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G5 Doctoral dissertation (article)
Decreased [³H]naloxone Binding in the Dentate Gyrus of Cloninger Type 1 Anxiety-Prone Alcoholics: A Postmortem Whole-Hemisphere Autoradiography Study
Laukkanen Virpi, Kärkkäinen Olli, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2015, Alcoholism-clinical and experimental research, 39, 8, 1352-1359. A1 Journal article (refereed), original research
Alkoholismin autoradiografiatutkimus
Storvik Markus, Laukkanen Virpi, Kupila Jukka, Kärkkäinen Olli, 2014, Dosis, 30, 3, 217. B1 Non-refereed journal articles
Increased metabotropic glutamate 2/3 receptor binding in the perigenual anterior cingulate cortex of Cloninger type 2 alcoholics: a whole-hemisphere autoradiography study
Laukkanen Virpi, Kärkkäinen Olli, Kupila Jukka, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2014, Alcohol and alcoholism, 50 (2015), 1, 62-67. A1 Journal article (refereed), original research
Lower [3H]Citalopram Binding in Brain Areas Related to Social Cognition in Alcoholics
Kärkkäinen Olli, Laukkanen Virpi, Haukijärvi Tuija, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2014, Alcohol and alcoholism, 2015; 50, 1, 46-50. A1 Journal article (refereed), original research
[3H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study
Kupila Jukka, Kärkkäinen Olli, Laukkanen Virpi, Häkkinen Merja, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2014, Psychiatry research: neuroimaging, 2015; 231, 3, 197-201. A1 Journal article (refereed), original research
AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study
Kärkkäinen Olli, Kupila Jukka, Häkkinen Merja, Laukkanen Virpi, Tupala Erkki, Kautiainen Hannu, Tiihonen Jari, Storvik Markus, 2013, Psychiatry research: neuroimaging, 214, 429-434. A1 Journal article (refereed), original research
Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics
Kärkkäinen Olli K, Lehtonen Marko, Laukkanen Virpi, Tupala Erkki, Hyytiä Petri, Kautiainen Hannu, Tiihonen Jari, Callaway JC, Storvik Markus, 2013, Alcohol, 47, 399-403. A1 Journal article (refereed), original research
mGluR1/5 receptor densities in the brains of alcoholic subjects: A whole-hemisphere autoradiography study
Kupila Jukka, Kärkkäinen Olli, Laukkanen Virpi, Tupala Erkki, Tiihonen Jari, Storvik Markus, 2012, Psychiatry research: neuroimaging, 2013:212, 245-250. A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Olli Kärkkäinen

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Keywords

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth

Bipolar Disorder and Poisoning due to Medicines or Illegal Substances

Blueprint of the distinct metabolite profiles of healthy pig heart chambers

Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Long term safety of ADHD medication in patients with schizophrenia spectrum disorders

Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy

Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine

Metabolic profiles of meconium in preeclamptic and normotensive pregnancies

On Challenges of Studying the Complex Role of Bile Acids in Alcohol-Related Liver Disease

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study

Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder

Alkoholi (etyylialkoholi, etanoli)

Alkoholien toksikokinetiikka

Alkoholimyrkytyskuolemat ja alkoholille altistuminen

Alkoholin akuutit vaikutukset

Alkoholin farmakokinetiikka

Alkoholitoleranssi ja vieroitusoireet

An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight

Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

Etanoli ja sikiö

Etanolimyrkytys

Etanolin karsinogeeninen vaikutus

Etanolin krooniset haittavaikutukset

Etyleeniglykolimyrkytys

Metanolimyrkytys

Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Linking Hypothermia and Altered Metabolism with TrkB Activation

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

The associations between metabolic profiles and sexual and physical abuse in depressed adolescent psychiatric outpatients: an exploratory pilot study

Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Microbiota-derived metabolites as drivers of gut–brain communication

No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies

A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use

Comparison of the level of allostatic load between patients with major depression and the general population

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome

Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients

Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A1

One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study

Response to Letter by Benson et al. on 'Hangover and the Effects of L-Cysteine'

Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

"notame": Workflow for Non-Targeted LC-MS Metabolic Profiling

Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles

Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up

In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species

L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

Metabolome of canine and human saliva: a non-targeted metabolomics study

Metabolomics analysis of plasma and adipose tissue samples from mice orally administered with polydextrose and correlations with cecal microbiota

Changes in the Human Metabolome Associated With Alcohol Use: A Review

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Effects of Long-term adolescent alcohol consumption on white matter integrity and their correlations with metabolic alterations

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study

Metabolic signature of extracellular vesicles depends on the cell culture conditions

Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

Repeated Transcranial Magnetic Stimulation-Induced Motor Evoked Potentials Correlate With the Subject-Specific Serum Metabolic Profile of Creatine

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

Decreased serum total cholesterol is associated with a history of childhood physical violence in depressed outpatients