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Finnish Vitamin D Study (FIND)
Leaders
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Tomi-Pekka Tuomainen
ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Sari Hantunen
Senior University LecturerInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Jyrki Virtanen
Associate ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences
Finnish Vitamin D Trial (FIND) conducted at the University of Eastern Finland in 2012–2018. In the FIND trial, 2,495 participants (men 60 years or older and women 65 years or older) were randomised for five years to either the placebo group or the groups that received either 40 or 80 micrograms (1600 or 3200 IU) of vitamin D3 per day. All participants were free of cardiovascular disease and cancer at the start of the trial and were allowed to use their own vitamin D supplement of up to 20 micrograms (800 IU) per day (the recommended intake for this age group at the time when the trial was started). At the beginning and during the trial, research forms were used to collect comprehensive information from the subjects on lifestyle, nutrition, risk factors for and the incidence of diseases. Information on the incidence of diseases and on deaths was also obtained from national health registers.
Approximately one fifth of the randomly selected subjects underwent more detailed examinations and provided blood samples.
News
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Taking high-dose vitamin D supplements for five years did not affect the incidence of cardiovascular disease or cancer
A trial by the University of Eastern Finland found that taking a much higher dose of vitamin D than recommended for five years did not affect total… -
Taking higher-than-recommended doses of vitamin D for five years reduced the risk of atrial fibrillation
Taking higher-than-recommended doses of vitamin D for five years reduced the risk of atrial fibrillation in older men and women, according to a new… -
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
o evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic… -
Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study
Epidemiological evidence suggests a role for vitamin D in type 2 diabetes prevention. We investigated the effects of vitamin D3 supplementation on…
Keywords
Leaders
-
Tomi-Pekka Tuomainen
ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Sari Hantunen
Senior University LecturerInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Jyrki Virtanen
Associate ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences
Researchers, UEF
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Ari Voutilainen
Research ManagerInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Matti Uusitupa
Professor, EmeritusInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences -
Heikki Kröger
ProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Toni Rikkonen
Senior Researcher -
Tommi Tolmunen
ProfessorInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Noora-Maria Ahl
Project ResearcherInstitute of Clinical Medicine, School of Medicine, Faculty of Health Sciences -
Pekka Mäntyselkä
ProfessorInstitute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences
Other group members
Publications
11 items-
Efficacy of vitamin D3 supplementation on cancer mortality: systematic review and individual patient data meta-analysis of randomised controlled trials
Kuznia, Sabine; Zhu, Anna; Akutsu, Taisuke; Buring, Julie E; Camargo Jr, Carlos A; Cook, Nancy R; Chen, Li-Ju; Cheng, Ting-Yuan David; Hantunen, Sari; Lee, I-Min; Manson, JoAnn E; Neale, Rachel E; Scragg, Robert; Shadyab, Aladdin H; Sha, Sha; Sluyter, John; Tuomainen, Tomi-Pekka; Urashima, Mitsuyoshi; Virtanen, Jyrki K; Voutilainen, Ari; Wactawski-Wende, Jean; Waterhouse, Mary; Brenner, Hermann; Schöttker, Ben. 2023. Ageing research reviews. 87: -
Multiplicative, additive, and interactive associations of 25-hydroxyvitamin D with lung and prostate cancer
Voutilainen, Ari; Virtanen, Jyrki K; Hantunen, Sari; Nurmi, Tarja; Kokko, Petra; Tuomainen, Tomi-Pekka. 2023. International journal for vitamin and nutrition research. 2024; 94: 133-142 -
The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: the Finnish Vitamin D Trial
Virtanen, Jyrki K; Hantunen, Sari; Lamberg-Allardt, Christel; Manson, JoAnn E; Nurmi, Tarja; Uusitupa, Matti; Voutilainen, Ari; Tuomainen, Tomi-Pekka. 2023. American heart journal. 264: 177-182 -
Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial: a randomized controlled trial
Virtanen, Jyrki K; Nurmi, Tarja; Aro, Antti; Bertone-Johnson, Elizabeth R; Hyppönen, Elina; Kröger, Heikki; Lamberg-Allardt, Christel; Manson, JoAnn E; Mursu, Jaakko; Mäntyselkä, Pekka; Suominen, Sakari; Uusitupa, Matti; Voutilainen, Ari; Tuomainen, Tomi-Pekka; Hantunen, Sari. 2022. American journal of clinical nutrition. 115: 1300-1310 -
Aina ajankohtainen D-vitamiini - uutta tietoa ihon ja aurinkosuojavoiteiden roolista
Virtanen, Jyrki; Hantunen, Sari. 2020. Duodecim. 136: 2441-2443 -
D-vitamiini syövän ehkäisyssä - totta vai tarua?
Hantunen, Sari; Virtanen, Jyrki. 2020. Duodecim. 136: 601-603 -
Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men
Virtanen JK, Giniatullin R, Mäntyselkä P, Voutilainen S, Nurmi T, Mursu J, Kauhanen J, Tuomainen TP. 2017. Scientific reports. 7: 39697 -
The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data
Jääskeläinen T, Itkonen ST, Lundqvist A, Erkkola M, Koskela T, Lakkala K, Dowling KG, Hull GLJ, Kröger H, Karppinen J, Kyllönen E, Härkänen T, Cashman KD, Männistö S, Lamberg-Allardt C. 2017. American journal of clinical nutrition. 105: 1512-1520 -
Glucose Metabolism Effects of Vitamin D in Prediabetes: the VitDmet Randomized Placebo-Controlled Supplementation Study
Tuomainen Tomi-Pekka, Virtanen Jyrki K, Voutilainen Sari, Nurmi Tarja, Mursu Jaakko, de Mello Vanessa DF, Schwab Ursula, Hakumäki Martti, Pulkki Kari, Uusitupa Matti. 2015. Journal of Diabetes Research. 2015: 8 pages -
The association between serum 25-hydroxyvitamin D3 concentration and risk of disease death in men: modification by magnesium intake
Mursu Jaakko, Nurmi Tarja, Voutilainen Sari, Tuomainen Tomi-Pekka, Virtanen Jyrki K. 2015. European journal of epidemiology. 30: 343-347