Neurobiology of disease

24.10.2017 -

The main goal of our research is to understand the mechanisms that lead to neurodegenerative diseases and to identify novel therapeutic approaches for them. We are interested in the effects of environmental factors (such as air pollution and viral infections) and lifestyle factors on brain health and in Alzheimer's disease. We also study the impact of the environment on mental health in children and adolescents.

We are currently studying transcellular and intercellular communication in neurodegenerative diseases, oxidative stress in astrocytes during neurodegeneration, the importance of Nrf2 in mitochondria, mitochondrial degradation: mechanisms and consequences in neurodegenerative diseases, biometal homeostasis in neurodegenerative diseases, and neurogenesis alterations in disease. We utilize several in vitro and in vivo models of neurodegenerative disease, including human brain cells. We employ a range of behavioral tests and magnetic resonance imaging to measure the outcome of therapeutic interventions in mouse models. We also utilize confocal imaging, ex vivo slice cultures and sophisticated gene transfer technologies in our research. We have recently developed a new model of the human olfactory mucosa.