Refine your search

NPH and Early AD´s Profile image

NPH and Early AD

Research group
01.01.2010 -
Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences


  • Normal pressure hydrocephalus (NPH) is a poorly understood neurological disorder presenting with impaired cognitive, gait and continency functions in various combinations as well as enlarged I-IV ventricles.
  • NPH patients may significantly benefit of shunt surgery. The most frequent differential diagnosis is Alzheimer’s disease (AD).
  • Neurosurgery of Kuopio University Hospital (KUH) solely serves Eastern Finnish population.
  • Since 1991 until 2010, our NPH protocol has included 24-hour intraventricular pressure monitoring together with a small right frontal cortical biopsy to exclude other neurodegenerative processes. Since 2010 the protocol has included systematic CSF sampling and brain biopsy is included in the shunt surgery.
  • Selected patients undergo advanced AD imaging at Turku PET Centre.
  • Kuopio NPH and AD Registry and Tissue Bank contains clinical and long-term follow up data as well as cortical biopsy samples of over 1100 patients investigated for possible NPH.
  • Kuopio NPH Research Group has a unique research window to NPH and AD through the cortical biopsy and CSF samples and long-term outcome data. This project is multidisciplinary approach, in which expertise from several fields of neuroscience at KUH and UEF campus area as well as national and international level are combined.

Aims of Research

  1. Genomic factors predisposing sporadic and familial idiopathic NPH.
  2. Novel biomarkers of iNPH and neurodegenerative diseases diagnostics and prognosis.
  3. Validation of CSF and PET diagnostics against brain biopsy in iNPH and AD.
  4. Personalized treatment of iNPH.


Selected Publications









2008 – 2011