Tumor-stroma interaction - Pasonen-Seppänen group´s Profile image

Tumor-stroma interaction - Pasonen-Seppänen group

Research group
01.09.2019 -
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
Information People Publications

Group description

Introducing image of the groupTumor-stroma interaction - Pasonen-Seppänen group

Pasonen-Seppänen group

The focus of our research is on tumor microenvironment (TME). Our overall goal is to elucidate how stromal cells, like fibroblasts and immune cells, and extracellular matrix molecules like hyaluronan affect melanoma progression. We are interested in tumor immunology, the role of macrophages and FoxP3+ regulatory T-cells in the formation of immunosuppressive TME in melanoma. The role of immune cells in tumor dissemination is well established yet the mechanisms that recruit the immune cells and regulate their function in the TME are poorly understood at the moment and are the targets of our research. In addition, we are seeking for new prognostic and diagnostic biomarkers for melanoma.

Cooperation

Keywords

3D -cell culture models cancer confocal microscopy ekstracellular matrix extracellular vesicle hyaluronan immune signature immunohistochemistry macrophage melanoma pro-tumor inflammation RNAseq tumor microenvironment tumor-stroma interaction

Other group members

  • Mari Valkonen
  • Satu Salmi
  • Otto Jokelainen
  • Kaisa Mäki-Mantila
  • Lasse Hämäläinen
  • Kiia Koivusalo

Publications

14 items