
Tumor-stroma interaction - Pasonen-Seppänen group
Group description
The focus of our research is on tumor microenvironment (TME). Our overall goal is to elucidate how stromal cells, like fibroblasts and immune cells, and extracellular matrix molecules like hyaluronan affect melanoma progression. We are interested in tumor immunology, the role of macrophages and FoxP3+ regulatory T-cells in the formation of immunosuppressive TME in melanoma. The role of immune cells in tumor dissemination is well established yet the mechanisms that recruit the immune cells and regulate their function in the TME are poorly understood at the moment and are the targets of our research. In addition, we are seeking for new prognostic and diagnostic biomarkers for melanoma.
Cooperation
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Kuopio University Hospital / FICAN East
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UEF
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UEF
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Münster University Hospital, Münster, Germany
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Lerner Research Institute, Cleveland Clinic, Cleveland, USA
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UEF
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UEF
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University of Turku
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UEF, Faculty of Health Sciences
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Kuopio University Hospital
Keywords
Other group members
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Mari Valkonen
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Satu Salmi
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Otto Jokelainen
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Kaisa Mäki-Mantila
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Lasse Hämäläinen
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Kiia Koivusalo
Publications
14 items-
The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB
Hämäläinen, L; Bart, G; Takabe, P; Rauhala, L; Deen, A; Pasonen-Seppänen, S; Kärkkäinen, E; Kärnä, R; Kumlin, T; Tammi, M; I; Tammi, RH. 2021. Histochemistry and cell biology. 5: 605-615 -
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study
Salmi, Satu; Lin, Anton; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Aaltonen, Niina; Sironen, Reijo; Siiskonen, Hanna; Pasonen-Seppänen, Sanna. 2021. Bmc cancer. 21: 641 -
Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma
Jokelainen, Otto; Pasonen-Seppänen, Sanna; Tammi, Markku; Mannermaa, Arto; Aaltomaa, Sirpa; Sironen, Reijo; Nykopp, Timo K. 2020. Urologic oncology: seminars and original investigations. 38: 686.e11-686.e22 -
Activated hyaluronan metabolism in the tumor matrix - Causes and consequences
Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H. 2019. Matrix biology. 78-79: 147-164 -
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23 -
Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation
Takabe, P; Kärnä, R; Rauhala, L; Tammi, M; Tammi, R; Pasonen-Seppänen, S. 2019. Journal of investigative dermatology. 139: 1993-2003.e4 -
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna. 2018. Bmc cancer. 18: 664 -
Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways
Rauhala, L; Jokela, T; Kärnä, R; Bart, G; Takabe, P: Oikari, S; Tammi, MI; Pasonen-Seppänen, S; Tammi, RH. 2018. Biochemical journal. 475: 1755-1772 -
Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C
Hämäläinen, L; Kärkkäinen, E; Takabe, P; Rauhala, L; Bart, G; Kärnä, R; Pasonen-Seppänen, S; Oikari, S; Tammi, MI; Tammi, RH. 2018. British journal of dermatology. 179: 651-661 -
The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma
Salmi, Satu; Siiskonen, Hanna; Sironen, Reijo; Tyynelä-Korhonen, Kristiina; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Auvinen, Päivi; Pasonen-Seppänen, Sanna. 2018. Melanoma research. 29: 237-247