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Sanna Pasonen-Seppänen

Sanna Pasonen-Seppänen

Senior University Lecturer

Group leader, Adj.prof in Cell Biology

Institute of Biomedicine, School of Medicine, Faculty of Health Sciences

[email protected] | +358 40 355 2030

Information Publications

Research groups

Molecular mechanisms of tumor-stroma interaction - Pasonen-Seppänen lab 01.01.2021 -

Publications

75/75 items

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers
Jokelainen, Otto; Rintala, Teemu; Remes, Satu; Pasonen-Seppänen, Sanna; Nykopp, Timo K.; Sironen, Reijo, 2025, The journal of pathology : Clinical research, 11, 4, e70035. A1 Journal article (refereed), original research
Poor survival of metastatic cancer patients hospitalized due to immune checkpoint inhibitor-related adverse events
Nurmela, Veera; Juntunen, Anni; Selander, Tuomas; Pasonen-Seppänen, Sanna; Kuittinen, Outi; Tiainen, Satu; Rönkä, Aino, 2025, Immunotherapy, 17, 5, 339-346. A1 Journal article (refereed), original research
Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma
Jokelainen, Otto; Rintala, Teemu J; Fortino, Vittorio; Pasonen-Seppänen, Sanna; Sironen, Reijo; Nykopp, Timo K, 2024, Scientific reports, 14, 1, 10626. A1 Journal article (refereed), original research
Expression of Programmed Death Ligand 1 and Indoleamine 2,3‐Dioxygenase in Oral Lichen Planus and Oral Lichenoid Lesions
Kemppainen, Olli; Mathlin, Andreas; Pasonen‐Seppänen, Sanna; Siponen, Maria, 2024, Journal of oral pathology and medicine, 53, 10, 613-621. A1 Journal article (refereed), original research
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa, 2024, Redox biology, 69, 103031. A1 Journal article (refereed), original research
Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NFκB-signaling
Kainulainen, Kirsi; Niskanen, Einari A; Kinnunen, Johanna; Mäki-Mantila, Kaisa; Hartikainen, Kiia; Paakinaho, Ville; Malinen, Marjo; Ketola, Kirsi; Pasonen-Seppänen, Sanna, 2024, Oncoimmunology, 13, 1, 2393442. A1 Journal article (refereed), original research
Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis
Ravindran, Aarthi; Holappa, Lari; Niskanen, Henri; Skovorodkin, Ilya; Kaisto, Susanna; Beter, Mustafa; Kiema, Miika; Selvarajan, Ilakya; Nurminen, Valtteri; Aavik, Einari; Aherrahrou, Rédouane; Pasonen-Seppänen, Sanna; Fortino, Vittorio; Laakkonen, Johanna P; Ylä-Herttuala, Seppo; Vainio, Seppo; Örd, Tiit; Kaikkonen, Minna U, 2024, Cardiovascular research, 120, 8, 869-882. A1 Journal article (refereed), original research
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
Tiainen, Satu; Nurmela, Veera; Selander, Tuomas; Turunen, Patrik; Pasonen-Seppänen, Sanna; Kettunen, Tiia; Kuittinen, Outi; Auvinen, Päivi; Rönkä, Aino, 2023, Bmc cancer, 23, 1, 1186. A1 Journal article (refereed), original research
Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium
Kashyap, Bina; Naumanen, Konsta; Mikkonen, Jopi; Dekker, Hannah; Schulten, Engelbert; Bloemena, Elisabeth; Pasonen-Seppänen, Sanna; Kullaa, Arja, 2022, Biomedicines, 10, 11, 2816. A1 Journal article (refereed), original research
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling
Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna, 2022, Journal of investigative dermatology, 1412, 11, 3041-3051.e10. A1 Journal article (refereed), original research
The Association of CD8+ Cytotoxic T Cells and Granzyme B+ Lymphocytes with Immunosuppressive Factors, Tumor Stage and Prognosis in Cutaneous Melanoma
Salmi, Satu; Hälinen, Kaisla; Lin, Anton; Suikkanen, Sanna; Jokelainen, Otto; Rahunen, Eija; Siiskonen, Hanna; Pasonen-Seppänen, Sanna, 2022, Biomedicines, 10, 12, 3209. A1 Journal article (refereed), original research
The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma
Takabe, Piia; Siiskonen, Hanna; Rönkä, Aino; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna, 2022, Frontiers in oncology, 11, 811434. A2 Review article, Literature review, Systematic review
The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB
Hämäläinen, L; Bart, G; Takabe, P; Rauhala, L; Deen, A; Pasonen-Seppänen, S; Kärkkäinen, E; Kärnä, R; Kumlin, T; Tammi, M; I; Tammi, RH, 2021, Histochemistry and cell biology, 5, 1, 605-615. A1 Journal article (refereed), original research
The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study
Salmi, Satu; Lin, Anton; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Aaltonen, Niina; Sironen, Reijo; Siiskonen, Hanna; Pasonen-Seppänen, Sanna, 2021, Bmc cancer, 21, 1, 641. A1 Journal article (refereed), original research
Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma
Jokelainen, Otto; Pasonen-Seppänen, Sanna; Tammi, Markku; Mannermaa, Arto; Aaltomaa, Sirpa; Sironen, Reijo; Nykopp, Timo K, 2020, Urologic oncology: seminars and original investigations, 38, 8, 686.e11-686.e22. A1 Journal article (refereed), original research
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
Aaltonen, Niina; Singha, Prosanta; Jakupovic, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha; Laitinen, Jarmo, 2020, Biological procedures online, 22, 6. A1 Journal article (refereed), original research
Activated hyaluronan metabolism in the tumor matrix - Causes and consequences
Tammi, Markku I; Oikari, Sanna; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Auvinen, Päivi; Tammi, Raija H, 2019, Matrix biology, 78-79, 147-164. A2 Review article, Literature review, Systematic review
Alterations in the expression of EMT-related proteins claudin-1, -4 and -7, E-cadherin, TWIST1 and ZEB1 in oral lichen planus
Hämäläinen, Lasse; Soini, Ylermi; Pasonen-Seppänen, Sanna; Siponen, Maria, 2019, Journal of oral pathology and medicine, 48, 8, 735-744. A1 Journal article (refereed), original research
As you sow, so shall you reap: Is there a "golden standard" to teach histology?
Felszeghy, S; Gilbert, G; Koskela, A; Nieminen, P; Sironen, R; Pasonen-Seppänen, S; Sointu, E; Morton, D; Mahonen, A, 2019, MedEd publish, 8, 3, 1-5. B1 Non-refereed journal articles
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K, 2019, Cellular and molecular life sciences, [Published: 09 December 2019], 1-23. A1 Journal article (refereed), original research
Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation
Takabe, P; Kärnä, R; Rauhala, L; Tammi, M; Tammi, R; Pasonen-Seppänen, S, 2019, Journal of investigative dermatology, 139, 9, 1993-2003.e4. A1 Journal article (refereed), original research
Metformin decreases hyaluronan synthesis by vascular smooth muscle cells
Sainio, A; Takabe, P; Oikari, S; Salomäki-Myftari, H; Koulu, M; Söderström, M; Pasonen-Seppänen, S; Järveläinen, H, 2019, Journal of investigative medicine, 68, 2, 383-391. A1 Journal article (refereed), original research
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Pölönen, P; Jawahar Deen, A; Leinonen, HM; Jyrkkänen, HK; Kuosmanen, S; Mononen, M; Jain, A; Tuomainen, T; Pasonen-Seppänen, S; Hartikainen, JM; Mannermaa, A; Nykter, M; Tavi, P; Johansen, T; Heinäniemi, M; Levonen, AL, 2019, Oncogene, 38, 7473-7490. A1 Journal article (refereed), original research
Using online game-based platforms to improve student performance and engagement in histology teaching
Felszeghy, S; Pasonen-Seppänen, S; Koskela, A; Nieminen, P; Härkönen, K; Paldanius, KMA; Gabbouj, S; Ketola, K; Hiltunen, M; Lundin, M; Haapaniemi, T; Sointu, E; Bauman, EB; Gilbert, GE; Morton, D; Mahonen, A, 2019, Bmc medical education, 19, 1, 273. A1 Journal article (refereed), original research
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Valkonen, Mari; Haapasalo, Hannu; Rilla, Kirsi; Tyynelä-Korhonen, Kristiina; Soini, Ylermi; Pasonen-Seppänen, Sanna, 2018, Bmc cancer, 18, 1, 664. A1 Journal article (refereed), original research
Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways
Rauhala, L; Jokela, T; Kärnä, R; Bart, G; Takabe, P: Oikari, S; Tammi, MI; Pasonen-Seppänen, S; Tammi, RH, 2018, Biochemical journal, 475, 10, 1755-1772. A1 Journal article (refereed), original research
Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C
Hämäläinen, L; Kärkkäinen, E; Takabe, P; Rauhala, L; Bart, G; Kärnä, R; Pasonen-Seppänen, S; Oikari, S; Tammi, MI; Tammi, RH, 2018, British journal of dermatology, 179, 3, 651-661. A1 Journal article (refereed), original research
The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma
Salmi, Satu; Siiskonen, Hanna; Sironen, Reijo; Tyynelä-Korhonen, Kristiina; Hirschovits-Gerz, Benjamin; Valkonen, Mari; Auvinen, Päivi; Pasonen-Seppänen, Sanna, 2018, Melanoma research, 29, 3, 237-247. A1 Journal article (refereed), original research
Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors
Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT, 2017, European journal of pharmaceutical sciences, 107, 97-111. A1 Journal article (refereed), original research
Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis
Jokela T, Kärnä R, Rauhala L, Bart G, Pasonen-Seppänen S, Oikari S, Tammi MI, Tammi RH, 2017, Journal of biological chemistry, 292, 12, 4861-4872. A1 Journal article (refereed), original research
Student-focused virtual histology education: Do new scenarios and digital technology matter?
Felszeghy Szabolcs, Pasonen-Seppänen Sanna, Koskela Ali, Mahonen Anitta, 2017, MedEd publish, 6, 3, 40. A1 Journal article (refereed), original research
Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)
Navia-Paldanius D, Patel JZ, López Navarro M, Jakupovic H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR, 2016, European journal of pharmaceutical sciences, 93, 253-263. A1 Journal article (refereed), original research
Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma
Poukka M, Bykachev A, Siiskonen H, Tyynelä-Korhonen K, Auvinen P, Pasonen-Seppänen S, Sironen R, 2016, Bmc cancer, 16, 313, 1-11. A1 Journal article (refereed), original research
Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer
Nykopp Timo K, Pasonen-Seppänen Sanna, Tammi Markku I, Tammi Raija H, Kosma Veli-Matti, Anttila Maarit, Sironen Reijo, 2015, Gynecologic oncology, 137, 1, 152-159. A1 Journal article (refereed), original research
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions
Siiskonen Hanna, Oikari Sanna, Pasonen-Seppänen Sanna, Rilla Kirsi, 2015, Frontiers in immunology, epub. A2 Review article, Literature review, Systematic review
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion
Takabe Piia, Bart Genevieve, Ropponen Antti, Rilla Kirsi, Tammi Markku, Tammi Raija, Pasonen-Seppanen Sanna, 2015, Experimental cell research, 337, 1, 1-15. A1 Journal article (refereed), original research
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma
Siiskonen Hanna, Poukka Mari, Bykachev Andrey, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna, Harvima Ilkka T, 2015, Melanoma research, [epub ahead of print 27 July 2015]. A1 Journal article (refereed), original research
The organic osmolyte betaine induces keratin 2 expression in rat epidermal keratinocytes - a genome-wide study in UVB irradiated organotypic 3D cultures
Rauhala Leena, Hämäläinen Lasse, Dunlop Thomas W, Pehkonen Petri, Bart Geneviève, Kokkonen Maarit, Tammi Markku, Tammi Raija, Pasonen-Seppänen Sanna, 2015, Toxicology in vitro, 30, 1, part B, 462-475. A1 Journal article (refereed), original research
Altered expression of hyaluronan, HAS1-2, and HYAL1-2 in oral lichen planus
Siponen Maria, Kullaa Arja, Nieminen Pentti, Salo Tuula, Pasonen-Seppänen Sanna, 2014, Journal of oral pathology and medicine, 2015; 44, 6, 401-409. A1 Journal article (refereed), original research
Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists
Yrjölä Sari, Sarparanta Mirkka, Airaksinen Anu J, Hytti Maria, Kauppinen Anu, Pasonen-Seppänen Sanna, Adinolfi Barbara, Nieri Paola, Manera Clementina, Keinänen Outi, Poso Antti, Nevalainen Tapio J, Parkkari Teija, 2014, European journal of pharmaceutical sciences, 2015; 67, 85-96. A1 Journal article (refereed), original research
rClca2 is associated with epidermal differentiation and is strongly downregulated by ultraviolet radiation
Bart G, Hämäläinen L, Rauhala L, Salonen P, Kokkonen M, Dunlop TW, Pehkonen P, Kumlin T, Tammi MI, Pasonen-Seppänen S, Tammi RH, 2014, British journal of dermatology, 171, 2, 376-387. A1 Journal article (refereed), original research
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles
Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI, 2013, Experimental cell research, 319, 13, 2006-2018. A1 Journal article (refereed), original research
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma
Siiskonen H, Poukka M, Tyynelä-Korhonen K, Sironen R, Pasonen-Seppänen S, 2013, Bmc cancer, 13, 181, e1-12. A1 Journal article (refereed), original research
Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1-3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling
Rauhala L, Hämäläinen L, Salonen P, Bart G, Tammi M, Pasonen-Seppänen S, Tammi R, 2013, Journal of biological chemistry, 288, 25, 17999-8012. A1 Journal article (refereed), original research
Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding
Jokela TA, Kuokkanen J, Kärnä R, Pasonen-Seppänen S, Rilla K, Kössi J, Laato M, Tammi RH, Tammi MI, 2013, Wound repair and regeneration, 21, 247-255. A1 Journal article (refereed), original research
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T, 2013, Chemistry and biology, 20, 379-390. A1 Journal article (refereed), original research
Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling
Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R, 2012, Histochemistry and cell biology, 138, 6, 895-911. A1 Journal article (refereed), original research
Role of CD44 in the organization of keratinocyte pericellular hyaluronan
Pasonen-Seppänen S, Hyttinen JM, Rilla K, Jokela T, Noble PW, Tammi M, Tammi R, 2012, Histochemistry and cell biology, 137, 107-120. A1 Journal article (refereed), original research
HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium
Rilla Kirsi, Pasonen-Seppänen Sanna, Kärnä Riikka, Karjalainen Hannu M, Törrönen Kari, Koistinen Ville, Tammi Markku I, Tammi Raija H, Teräväinen Terhi, Manninen Aki, 2011, Histochemistry and cell biology, 137, 2, 153-164. A1 Journal article (refereed), original research
4-methylumbelliterone inhibits tumor cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors
Edward M, Quinn JA, Pasonen-Seppänen SM, McCann BA & Tammi RH, 2010, British journal of dermatology, 162, 6, 1224-1232. A1 Journal article (refereed), original research
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
Kultti A, Pasonen-Seppänen S, Jauhiainen Marjo, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI, 2009, Experimental cell research, 315, 1914-1923. A1 Journal article (refereed), original research
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling
Makkonen KM, Pasonen-Seppänen S, Törrönen K, Tammi MI, Carlberg C, 2009, Journal of biological chemistry, 284, 27, 18270-18281. A1 Journal article (refereed), original research
All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes
Pasonen-Seppänen SM, Maytin EV, Törrönen KJ, Hyttinen JMT, Hascall VC, MacCallum DK, Kultti AH, Jokela TA, Tammi MI, Tammi RH, 2008, Journal of investigative dermatology, 128, 797-807. A1 Journal article (refereed), original research
Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT Cells
Skoog T, Elomaa O, Pasonen-Seppänen SM, Forsberg S, Ahokas K, Jeskanen L, Pärssinen J, Tiala I, Rollman O, Lohi J, Saarialho-Kere U, 2008, Journal of investigative dermatology, 129, 1, 119-30. A1 Journal article (refereed), original research
Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: The effect of skin permeation enhancers
Pappinen S, Tikkinen S, Pasonen-Seppänen S, Murtomäki L, Suhonen M, Urtti A, 2007, European journal of pharmaceutical sciences, 30, 240-250. A1 Journal article (refereed), original research
Regulation of Keratinocyte Differentiation and Hyaluronan Metabolism in an Organotypic Keratinocyte Culture
Pasonen-Seppänen S, 2006, Forum for nordic dermato-venereology, 11, 3, 74-76. D1 Article in a trade journal
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N1-acetyltransferase overexpression
Pietilä M, Pirinen E, Keskitalo S, Juutinen S, Pasonen-Seppänen S, Keinänen T, Alhonen L, Jänne J, 2005, Journal of investigative dermatology, 124, 3, 596-601. A1 Journal article (refereed), original research
Hyaluronan and CD44 in epidermal activation
Tammi M, Törrönen K, Pasonen-Seppänen S, Karvinen S, Rilla K, Pienimäki J-P, Tammi R, 2005, Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003., 641-647. A4 Conference proceedings
Hyaluronan degradation in epidermis
Tammi RH, Pasonen-Seppänen S, Kultti A, Hyttinen JMT, MacCallum DK, Hascall VC, Tammi MI, 2005, Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications, 241-245. A4 Conference proceedings
Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury
Tammi R, Pasonen-Seppänen S, Kolehmainen E, Tammi M, 2005, Journal of investigative dermatology, 124, 898-905. A1 Journal article (refereed), original research
Rat epidermal keratinocyte organotypic culture (ROC) as a model for chemically induced skin irritation testing
Pappinen S, Pasonen-Seppänen S, Suhonen M, Tammi R, Urtti A, 2005, Toxicology and applied pharmacology, 208, 233-241. A1 Journal article (refereed), original research
Regulation of Keratinocyte Differentiation and Hyaluronan Metabolism in an Organotypic Keratinocyte Culture
Pasonen-Seppänen S, 2005, Kuopio University Publications D. Medical Sciences. G5 Doctoral dissertation (article)
Retinoic acid upregulates hyaluronan production but retards keratinocyte differentation
Pasonen-Seppänen S, Tammi M, Törrönen K, MacCallum D, Hascall VC, Maytin E, Tammi R, 2005, Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003, 565-569. A4 Conference proceedings
Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation
Rilla K, Hyttinen JMT, Törrönen K, Pasonen-Seppänen S, Heldin P, Spicer AP, Rieppo J, Mättö M, Tammi M, Tammi R, 2005, Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications. Hyaluronan 2003., 637-640. A4 Conference proceedings
The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene
Saavalainen K, Pasonen-Seppänen S, Dunlop TW, Tammi R, Tammi MI, Carlberg C, 2005, Journal of biological chemistry, 280, 15, 14636-14644. A1 Journal article (refereed), original research
Wounding-induced upregulations of Has2/Has3 expression and hyaluronan synthesis in adult mouse epidermis correlates with keratinocyte migration and proliferation
Pasonen-Seppänen S, Hyttinen J, Kolehmainen E, Tammi M, Tammi R, 2005, Balazs EA, Hascall VC, Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications Hyaluronan 2003, 561-564. A4 Conference proceedings
The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor
Rilla K, Pasonen-Seppänen S, Rieppo J, Tammi M, Tammi R, 2004, Journal of investigative dermatology, 123, 708-714. A1 Journal article (refereed), original research
EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation
Pasonen-Seppänen S, Karvinen S, Törrönen K, Hyttinen JMT, Jokela T, Lammi MJ, Tammi MI, Tammi R, 2003, Journal of investigative dermatology, 120, 1038-1044. A1 Journal article (refereed), original research
Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin
Suhonen TM, Pasonen-Seppänen S, Kirjavainen M, Tammi M, Tammi R, Urtti A, 2003, European journal of pharmaceutical sciences, 20, 107-113. A1 Journal article (refereed), original research
Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3
Karvinen S, Pasonen-Seppänen S, Hyttinen JMT, Pienimäki J-P, Törrönen K, Jokela TA, Tammi MI, Tammi R, 2003, Journal of biological chemistry, 278, 49, 49495-49504. A1 Journal article (refereed), original research
Hyaluronan metabolism and distribution in stratified, differentiated cultures of epidermal keratinocytes
Pasonen-Seppänen S, Tammi R, Tammi M, Hogg M, Hascall VC, MacCallum DK, 2002, Kennedy JF, Phillips GO, Williams PA, Hascall VC, Hyaluronan. Chemical, Biochemical and Biological Aspects, 511-516. A3 Book section, Chapters in research books
Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan
Pienimäki J-P, Rilla K, Csaba F, Sironen RK, Karvinen S, Pasonen S, Lammi MJ, Tammi R, Hascall VC, Tammi MI, 2001, Journal of biological chemistry, 276, 23, 20428-20435. A1 Journal article (refereed), original research
Formation of permeability barrier in epidermal organotypic culture for studies on drug transport
Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Miettinen M, Urtti A, Tammi M, Tammi R, 2001, Journal of investigative dermatology.
Vitamin C enhances differentation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier
Pasonen-Seppänen S, Suhonen TM, Kirjavainen M, Suihko E, Urtti A, Miettinen M, Hyttinen M, Tammi M, Tammi R, 2001, Histochemistry and cell biology, 116, 287-297. A1 Journal article (refereed), original research
A preformed basal lamina alters the metabolism and distribution of hyaluronan in epidermal keratinocytes "organotypic" cultures grown on collagen matrices
Tammi RH, Tammi MI, Hascall VC, Hogg M, Pasonen S, MacCallum DK, 2000, Histochemistry and cell biology, 113, 265-277. A1 Journal article (refereed), original research

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Sanna Pasonen-Seppänen

Research groups

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers

Poor survival of metastatic cancer patients hospitalized due to immune checkpoint inhibitor-related adverse events

Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma

Expression of Programmed Death Ligand 1 and Indoleamine 2,3‐Dioxygenase in Oral Lichen Planus and Oral Lichenoid Lesions

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NFκB-signaling

Translatome profiling reveals Itih4 as a novel smooth muscle cell–specific gene in atherosclerosis

A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors

Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

The Association of CD8+ Cytotoxic T Cells and Granzyme B+ Lymphocytes with Immunosuppressive Factors, Tumor Stage and Prognosis in Cutaneous Melanoma

The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma

The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB

The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma - an immunohistochemical study

Cellular hyaluronan is associated with a poor prognosis in renal cell carcinoma

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Activated hyaluronan metabolism in the tumor matrix - Causes and consequences

Alterations in the expression of EMT-related proteins claudin-1, -4 and -7, E-cadherin, TWIST1 and ZEB1 in oral lichen planus

As you sow, so shall you reap: Is there a "golden standard" to teach histology?

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation

Metformin decreases hyaluronan synthesis by vascular smooth muscle cells

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

Using online game-based platforms to improve student performance and engagement in histology teaching

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y2, Ca2+-signaling, and MAPK pathways

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C

The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma

Design, Synthesis, and Biological Evaluation of 2,4-Dihydropyrano[2,3-c]pyrazole Derivatives as Autotaxin Inhibitors

Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alfa/beta-hydrolase domain containing 11 (ABHD11)

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma

Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

The organic osmolyte betaine induces keratin 2 expression in rat epidermal keratinocytes - a genome-wide study in UVB irradiated organotypic 3D cultures

Altered expression of hyaluronan, HAS1-2, and HYAL1-2 in oral lichen planus

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

rClca2 is associated with epidermal differentiation and is strongly downregulated by ultraviolet radiation

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1-3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase

Melanoma cell-derived factors stimulate hyaluronan in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K_AKT and p38 -signaling

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

4-methylumbelliterone inhibits tumor cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling

All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes

Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT Cells

Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: The effect of skin permeation enhancers

Regulation of Keratinocyte Differentiation and Hyaluronan Metabolism in an Organotypic Keratinocyte Culture

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N1-acetyltransferase overexpression

Hyaluronan and CD44 in epidermal activation

Hyaluronan degradation in epidermis

Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury

Rat epidermal keratinocyte organotypic culture (ROC) as a model for chemically induced skin irritation testing

Regulation of Keratinocyte Differentiation and Hyaluronan Metabolism in an Organotypic Keratinocyte Culture

Retinoic acid upregulates hyaluronan production but retards keratinocyte differentation

Suppression of hyaluronan synthesis by 4-methylumbelliferone retards keratinocyte migration and proliferation

The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene

Wounding-induced upregulations of Has2/Has3 expression and hyaluronan synthesis in adult mouse epidermis correlates with keratinocyte migration and proliferation

The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor

EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation

Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin

Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3

Hyaluronan metabolism and distribution in stratified, differentiated cultures of epidermal keratinocytes

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

Formation of permeability barrier in epidermal organotypic culture for studies on drug transport

Vitamin C enhances differentation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier

A preformed basal lamina alters the metabolism and distribution of hyaluronan in epidermal keratinocytes "organotypic" cultures grown on collagen matrices