Analytical Unit of the School of Pharmacy
Contact persons
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Marko Lehtonen
Associate ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Tuulia Tynkkynen
University LecturerSchool of Pharmacy, Faculty of Health Sciences
The Analytical Unit at the School of Pharmacy, University of Eastern Finland, provides advanced analytical expertise and services in mass spectrometry and NMR spectroscopy for academic and industrial research.
The unit focuses on the development and application of mass spectrometry–based methods for the analysis of metabolites, drugs, proteins, and other biomolecules. Our work supports a wide range of research areas, including medicine, biology, drug development, nutrition, and environmental sciences. We offer both targeted quantitative analyses and untargeted profiling approaches, with a strong emphasis on method development, validation, and data quality in accordance with international guidelines.
Our analytical platforms include LC-MS/MS, GC-MS, high-resolution mass spectrometry, and chromatographic techniques (HPLC-UV/DAD, HPLC-ECD). High-resolution MS is used particularly for the screening and identification of unknown compounds, as well as for metabolomics and lipidomics studies, enabling comprehensive characterization of biological, pharmaceutical, and environmental samples.
In addition to mass spectrometry, the unit has strong expertise in NMR spectroscopy, which is used for metabolomics, structural analysis, and quantitative determination of small molecules. Our NMR capabilities support applications ranging from metabolic profiling and impurity analysis to drug stability studies and structure elucidation using advanced one- and two-dimensional techniques.
The unit operates state-of-the-art instrumentation, including high-resolution mass spectrometers and Bruker 600 MHz NMR systems equipped with cryoprobes and automated sample handling, enabling efficient analysis of large sample sets.
In addition to research and analytical services, the unit plays a key role in education in analytical chemistry and pharmaceutical analysis. We contribute extensively to teaching at bachelor’s, master’s, and doctoral levels, and supervise many theses. Our teaching combines theoretical foundations with hands-on training in modern analytical techniques.
Overall, the unit aims to deliver high-quality analytical data and expertise, while supporting both research excellence and the education of future experts in pharmaceutical and analytical sciences.
Keywords
Professors
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Seppo Auriola
ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Jouko Vepsäläinen
ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Marko Lehtonen
Associate ProfessorSchool of Pharmacy, Faculty of Health Sciences
Senior Researchers
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Tuulia Tynkkynen
University LecturerSchool of Pharmacy, Faculty of Health Sciences -
Sirpa Peräniemi
Senior ResearcherSchool of Pharmacy, Faculty of Health Sciences -
Nina Sipari
Head of LaboratorySchool of Pharmacy, Faculty of Health Sciences
Post-doctoral Researchers
Doctoral Researchers
Technicians
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Miia-Liisa Reponen
Senior Laboratory TechnicianSchool of Pharmacy, Faculty of Health Sciences -
Juulia Kuparinen
Laboratory AssistantSchool of Pharmacy, Faculty of Health Sciences
Contact persons
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Marko Lehtonen
Associate ProfessorSchool of Pharmacy, Faculty of Health Sciences -
Tuulia Tynkkynen
University LecturerSchool of Pharmacy, Faculty of Health Sciences
Researchers
Publications
128 items-
Composition-properties-performance relationships of alkali-activated materials and geopolymers over extended silicon-aluminum-sodium-calcium ratios in adsorption applications
Hossain, Md Faysal; Hossain, Md Akram; Bhuyan, Mohammad; Vepsalainen, Jouko; Luukkonen, Tero, 2026, Materials & design, 262, 115471. A1 Journal article (refereed), original research -
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα‑Aroyl‑N‑aryl-phenylalanine Amides
Doering, Johannes; Meerz, Erik; Seidel, Rüdiger W; Lang, Markus; Kany, Andreas M; Auriola, Seppo; Juvonen, Risto Olavi; Raunio, Hannu; Goddard, Richard; Zimmerman, Matthew D; Dartois, Véronique; Hirsch, Anna KH; Dick, Thomas; Richter, Adrian, 2026, ACS infectious diseases, [Epub ahead of print 2 Jun 2026], 1-12. A1 Journal article (refereed), original research -
IFNγ alters the aberrant phenotype of α-synuclein–treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons
Niskanen, Jonna; Hakosalo, Vili; Hämäläinen, Wilhelmiina; Kälvälä, Sara; Hyvönen, Mervi T; Zhang, Yinjia; Luk, Kelvin C; Koistinaho, Jari; Lehtonen, Marko; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2026, Neuroscience, 603, 201-213. A1 Journal article (refereed), original research -
Metabolomic insights: LC–MS profiling of human placental tissue from SSRI-treated pregnancies
Itkonen, Anna; Kärkkäinen, Olli; Lehtonen, Marko; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2026, European journal of medical research, 31, 258. A1 Journal article (refereed), original research -
Plasma metabolomics and red blood cell fatty acid profiles in adolescent mental health
Piironen, Aino Kaisa; Afonin, Alexey M; Zarei, Iman; Koistinen, Ville; Lehtonen, Marko; Hämäläinen, Venla; Sala-Vila, Aleix; Lázaro, Iolanda; Julvez, Jordi; van Kamp, Irene; Kanninen, Katja M, 2026, Comprehensive psychoneuroendocrinology, 26, 100347. A1 Journal article (refereed), original research -
Valorization of rice straw through FeCl3 pretreatment: experiments modelling and optimization
Manna, Dinabandhu; Chowdhury, Ranjana; Kuittinen, Suvi; Pappinen, Ari; Vepsäläinen, Jouko; Hassan, Md. Kamrul, 2026, Biomass conversion and biorefinery, 16, 3, 118. A1 Journal article (refereed), original research -
A new urinary biomarker reflecting the progesterone excretion pattern identified through serum steroid and urinary progesterone metabolite analysis during pro-oestrus and oestrus in female dogs (Canis familiaris)
Pennanen, Tia M; Häkkinen, Merja R; Juvonen, Risto O; Vepsäläinen, Jouko J; Auriola, Seppo; Viitala, Sari M, 2025, Animal reproduction science, 284, 108054. A1 Journal article (refereed), original research -
A study protocol for chemical analysis and toxicity testing of virgin and recycled microplastics and associated chemicals
Järvelä, Essi; Peräniemi, Sirpa; Vepsäläinen, Jouko; Hrovat, Blaž; Raninen, Kaisa; Tomppo, Laura; Koistinen, Arto; Rysä, Jaana, 2025, Science of the total environment, 975, 179287. A1 Journal article (refereed), original research -
Advancements and feasibility of synergistic approaches in phosphorus recovery from wastewater: A critical review
Kaur, Parminder; Szlachta, Małgorzata; Xu, Junhua; Vepsäläinen, Jouko; Lappalainen, Reijo; Hussin, Farihahusnah; Aroua, Mohamed Kheireddine, 2025, Journal of environmental management, 386, 125786. A2 Review article, Literature review, Systematic review -
Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2025, Basic and clinical pharmacology and toxicology, 136, 5, 1-11. A1 Journal article (refereed), original research