Mervi Hyvönen
Grant-funded Researcher
Ph.D., Adjunct Professor in Molecular Medicine
School of Pharmacy, Faculty of Health Sciences
mervi.hyvonen@uef.fi
I work in arctic research strategic programme funded by the Academy of Finland, in the group led by Professor Jouko Vepsäläinen. We collaborate with Professor Alex R. Khomutov from the Moscow Engelhardt Institute. Our project “Biogenic amines in the health challenge caused by the changing arctic climate; ABIOHEALTH” belongs to theme “Changing arctic climate, changing diseases”. We investigate the role and functions of polyamines in the biotic and abiotic stresses caused by the chaning arctic climate. We aim to develop novel polyamine-based drug candidates against pathogenic micro-organisms and diseases which are spreading to the arctic area due to theclimate change.
Research groups
Keywords
Publications
57/57 items-
Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions
Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R.. 2022. International journal of molecular sciences. 23: A1 Journal article (refereed), original research -
α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation
Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. Biomolecules. 11: 707 A1 Journal article (refereed), original research -
Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis
Khandazhinskaya, Anastasia; Eletskaya, Barbara; Fateev, Ilja; Kharitonova, Maria; Konstantinova, Irina; Barai, Vladimir; Azhayev, Alex; Hyvonen, Mervi T.; Keinanen, Tuomo A.; Kochetkov, Sergey; Seley-Radtke, Katherine; Khomutov, Alex; Matyugina, Elena. 2021. Organic and biomolecular chemistry. 19: 7379-7389 A1 Journal article (refereed), original research -
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li, Qian; Hagberg, Carolina E.; Silva Cascales, Helena; Lang, Shuai; Hyvönen, Mervi T.; Salehzadeh, Firoozeh; Chen, Ping; Alexandersson, Ida; Terezaki, Eleni; Harms, Matthew J.; Kutschke, Maria; Arifen, Nahida; Krämer, Niels; Aouadi, Myriam; Knibbe, Carole; Boucher, Jeremie; Thorell, Anders; Spalding, Kirsty L.. 2021. Nature medicine. 27: 1941-1953 A1 Journal article (refereed), original research -
Chemical activation of SAT1 corrects diet-induced metabolic syndrome
Castoldi, Francesca; Hyvönen, Mervi T; Durand, Sylvère; Aprahamian, Fanny; Sauvat, Allan; Malik, Shoaib A; Baracco, Elisa Elena; Vacchelli, Erika; Opolon, Paule; Signolle, Nicolas; Lefevre, Déborah; Bossut, Noelie; Eisenberg, Tobias; Dammbrueck, Christopher; Pendl, Tobias; Kremer, Margerie; Lachkar, Sylvie; Einer, Claudia; Michalke, Bernhard; Zischka, Hans et al. [incl. Keinänen, Tuomo]. 2020. Cell death and differentiation. 27: 2904-2920 A1 Journal article (refereed), original research -
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Biomolecules. 10: 406 A1 Journal article (refereed), original research -
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine
Khomutov, MA; Hyvönen, MT; Salikhov, AI; Chizhov, AO; Ryzhov, IM; Kochetkov, SN; Vepsäläinen, J; Keinänen, TA; Khomutov, AR. 2020. Russian journal of bioorganic chemistry. 46: 686-692 A1 Journal article (refereed), original research -
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Journal of medicinal chemistry. 62: 11335-11347 A1 Journal article (refereed), original research -
Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase
Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Mendeleev communications. 28: 479-481 A1 Journal article (refereed), original research -
Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration
Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Biochemical journal. 475: 663-676 A1 Journal article (refereed), original research