Olli Kärkkäinen

Metabolomic insights: LC–MS profiling of human placental tissue from SSRI-treated pregnancies

Itkonen, Anna; Kärkkäinen, Olli; Lehtonen, Marko; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2026, European journal of medical research, 31, 258. A1 Journal article (refereed), original research

Predictive value of alcohol use questionnaires for adverse pregnancy outcomes: Evidence from a Finnish birth cohort

Nuttunen, Päivi; Purmonen, Timo; Ålander, Ulpu; Kärkkäinen, Olli; Keski‐Nisula, Leea, 2026, Acta obstetricia et gynecologica scandinavica, [First published: 08 April 2026], 1-9. A1 Journal article (refereed), original research

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth

Masvosva, Wadzanai; Voutilainen, Taija; Lehtonen, Marko; Haikonen, Retu; Auriola, Seppo; Keski‐Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2025, Basic and clinical pharmacology and toxicology, 136, 5, 1-11. A1 Journal article (refereed), original research

Bipolar Disorder and Poisoning due to Medicines or Illegal Substances

Niskanen, Mikko; Kärkkäinen, Olli; Taipale, Heidi; Lieslehto, Johannes; Tiihonen, Jari; Hamina, Aleksi, 2025, Acta psychiatrica scandinavica, 152, 4, 299-307. A1 Journal article (refereed), original research

Blueprint of the distinct metabolite profiles of healthy pig heart chambers

Haikonen, Retu; Meuronen, Topi; Koistinen, Ville; Kärkkäinen, Olli; Tuomainen, Tomi; Solano-Aguilar, Gloria I; Urban, Joseph F; Lehtonen, Marko; Tavi, Pasi; Hanhineva, Kati, 2025, Journal of molecular and cellular cardiology plus, 13, 100462. A1 Journal article (refereed), original research

Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes

Juvonen, Risto O; Postila, Pekka A; Singh, Pankaj Kumar; Huuskonen, Juhani; Timonen, Juri; Fashe, Muluneh; Hussain, Rasikh; Aqip, Zaeema; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T, 2025, European journal of pharmaceutical sciences, 213, 107249. A1 Journal article (refereed), original research

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Amadieu, Camille; Ahmed, Hany; Leclercq, Sophie; Koistinen, Ville; Leyrolle, Quentin; Stärkel, Peter; Bindels, Laure B; Layé, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli; De Timary, Philippe; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Clinical nutrition ESPEN, 66, 361-371. A1 Journal article (refereed), original research

Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells

Wallén, E.; Rämö, K.; Vehviläinen, J.; Sokka, J.; Lehtonen, M.; Otonkoski, T.; Trokovic, R.; Auvinen, P.; Kärkkäinen, O.; Kaminen-Ahola, N, 2025, Disease models and mechanisms, 18, 6, dmm052150. A1 Journal article (refereed), original research

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health

Neyrinck, Audrey M; Ahmed, Hany; Leyrolle, Quentin; Leclercq, Sophie; Amadieu, Camille; Meuronen, Topi; Layé, Sophie; Cani, Patrice D; Kärkkäinen, Olli; Bindels, Laure B; Hanhineva, Kati; Delzenne, Nathalie M, 2025, Scientific reports, 15, 1, 15455. A1 Journal article (refereed), original research

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Hellén, Marianna; Weert, Isabelle; Müller, Stephan A.; Räsänen, Noora; Kettunen, Pinja; Lehtonen, Šárka; Peitz, Michael; Fließbach, Klaus; Takalo, Mari; Koskuvi, Marja; Lichtenthaler, Stefan F.; Leinonen, Ville; Ramirez, Alfredo; Kärkkäinen, Olli; Hiltunen, Mikko; Koistinaho, Jari; Rõlova, Taisia, 2025, Journal of neuroinflammation, 22, 1, 147. A1 Journal article (refereed), original research

Long term safety of ADHD medication in patients with schizophrenia spectrum disorders

Luykx, Jurjen J; Corbeil, Olivier; Kärkkäinen, Olli; Tanskanen, Antti; Mittendorfer-Rutz, Ellenor; Tiihonen, Jari; Taipale, Heidi, 2025, Molecular psychiatry, 30, 10, 4859-4867. A1 Journal article (refereed), original research

Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy

Itkonen, Anna; Kärkkäinen, Olli; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2025, Metabolomics, 21, 5, 123. A1 Journal article (refereed), original research

Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine

Masvosva, Wadzanai; Lehtonen, Marko; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Rysä, Jaana; Kok, Eloise; Kärkkäinen, Olli, 2025, Addiction biology, 30, 6, e70064. A1 Journal article (refereed), original research

Metabolic profiles of meconium in preeclamptic and normotensive pregnancies

Toivonen, Elli; Sikkinen, Jutta; Salonen, Anne; Kärkkäinen, Olli; Koistinen, Ville; Klåvus, Anton; Meuronen, Topi; Heini, Tuomas; Maltseva, Arina; Niku, Mikael; Jääskeläinen, Tiina; Laivuori, Hannele, 2025, Metabolomics, 21, 1, 21. A1 Journal article (refereed), original research

Metabolomics of aortic valve stenosis: Are aortic valve stenosis and sclerosis different diseases?

Koljonen, Elisa; Kärkkäinen, Olli; Haikonen, Retu; Turpeinen, Anu; Hartikainen, Juha; Rysä, Jaana, 2025, Atherosclerosis, 411, 120549. A1 Journal article (refereed), original research

On Challenges of Studying the Complex Role of Bile Acids in Alcohol-Related Liver Disease

Stärkel, Peter; Kärkkäinen, Olli, 2025, Liver international, 45, 8, e70222. B1 Non-refereed journal articles

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study

Puhakka, Eemeli; Ahmed, Hany; Haikonen, Retu; Leclercq, Sophie; Hanhineva, Kati; Maccioni, Luca; Amadieu, Camille; Lehtonen, Marko; Männistö, Ville; Rysä, Jaana; Stärkel, Peter; Kärkkäinen, Olli, 2025, Liver international, 45, 6, 1-11. A1 Journal article (refereed), original research

Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder

Kärkkäinen, Olli; Tolmunen, Tommi; Kivimäki, Petri; Kurkinen, Karoliina; Ali-Sisto, Toni; Mäntyselkä, Pekka; Valkonen-Korhonen, Minna; Koivumaa-Honkanen, Heli; Honkalampi, Kirsi; Ruusunen, Anu; Velagapudi, Vidya; Lehto, Soili M, 2024, Alcohol, 120, 161-167. A1 Journal article (refereed), original research

An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence

Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili M; Luoma, Ilona; Kraav, Siiri-Liisi; Kivimäki, Petri; Therman, Sebastian; Tolmunen, Tommi, 2024, Translational psychiatry, 14, 1, 466. A1 Journal article (refereed), original research

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight

Masalin, Senja; Klåvus, Anton; Rönö, Kristiina; Koistinen, Heikki A; Koistinen, Ville; Kärkkäinen, Olli; Jääskeläinen, Tiina J; Klemetti, Miira M, 2024, Diabetologia, 67, 11, 2539-2554. A1 Journal article (refereed), original research

Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder

Zillich, Lea; Cetin, Metin; Hummel, Elisabeth M; Poisel, Eric; Fries, Gabriel R; Frank, Josef; Streit, Fabian; Foo, Jerome C; Sirignano, Lea; Friske, Marion M; Lenz, Bernd; Hoffmann, Sabine; Adorjan, Kristina; Kiefer, Falk; Bakalkin, Georgy; Hansson, Anita C; Lohoff, Falk W; Kärkkäinen, Olli; Kok, Eloise; Karhunen, Pekka J; Sutherland, Greg T; Walss‐Bass, Consuelo; Spanagel, Rainer; Rietschel, Marcella; Moser, Dirk A; Witt, Stephanie H, 2024, Alcohol, clinical & experimental research, 48, 2, 250-259. A1 Journal article (refereed), original research

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

Leclercq, Sophie; Ahmed, Hany; Amadieu, Camille; Petit, Géraldine; Koistinen, Ville; Leyrolle, Quentin; Poncin, Marie; Stärkel, Peter; Kok, Eloise; Karhunen, Pekka J; de Timary, Philippe; Laye, Sophie; Neyrinck, Audrey M; Kärkkäinen, Olli K; Hanhineva, Kati; Delzenne, Nathalie, 2024, eLife, 13, RP96937. A1 Journal article (refereed), original research

Etanoli ja sikiö

Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1322-1323. D2 Article in a professional book (incl. an introduction by the editor)

Etanolimyrkytys

Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1315. D2 Article in a professional book (incl. an introduction by the editor)

Etanolin karsinogeeninen vaikutus

Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1321. D2 Article in a professional book (incl. an introduction by the editor)

Etanolin krooniset haittavaikutukset

Korpi, Esa R.; Kärkkäinen, Olli; Sahlman, Heidi; Rysä, Jaana, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1318-1321. D2 Article in a professional book (incl. an introduction by the editor)

Etyleeniglykolimyrkytys

Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1317. D2 Article in a professional book (incl. an introduction by the editor)

Metanolimyrkytys

Juvonen, Risto; Savolainen, Kai; Kärkkäinen, Olli, 2024, Ruskoaho, Heikki; Hakkola, Jukka; Kantele, Anu; Korpi, Esa R; Moilanen, Eeva; Piepponen, Petteri; Rysä, Jaana; Savontaus, Eriika; Tenhunen, Olli, Lääketieteellinen farmakologia ja toksikologia, 1315-1316. D2 Article in a professional book (incl. an introduction by the editor)

Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies

Voutilainen, Taija; Keski-Nisula, Leea; Rysä, Jaana; Kärkkäinen, Olli, 2024, Basic and clinical pharmacology and toxicology, 134, 4, 543-555. A1 Journal article (refereed), original research

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Couacault, Pauline; Avella, Dennisse; Londoño-Osorio, Sara; Lorenzo, Ana S; Gradillas, Ana; Kärkkäinen, Olli; Want, Elizabeth; Witting, Michael, 2024, Analytical science advances, 5, 5-6, e2400002. A2 Review article, Literature review, Systematic review

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Husso, Aleksi; Pessa-Morikawa, Tiina; Koistinen, Ville Mikael; Kärkkäinen, Olli; Kwon, Hyuk Nam; Lahti, Leo; Iivanainen, Antti; Hanhineva, Kati; Niku, Mikael, 2023, Bmc biology, 21, 1, 207. A1 Journal article (refereed), original research

Linking Hypothermia and Altered Metabolism with TrkB Activation

Alitalo, Okko; González-Hernández, Gemma; Rosenholm, Marko; Kohtala, Piia; Matsui, Nobuaki; Müller, Heidi Kaastrup; Theilmann, Wiebke; Klein, Anders; Kärkkäinen, Olli; Rozov, Stanislav; Rantamäki, Tomi; Kohtala, Samuel, 2023, Acs chemical neuroscience, 14, 17, 3212-3225. A1 Journal article (refereed), original research

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka, 2023, Molecular metabolism, 76, 101779. A1 Journal article (refereed), original research

The associations between metabolic profiles and sexual and physical abuse in depressed adolescent psychiatric outpatients: an exploratory pilot study

Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili M; Luoma, Ilona; Kraav, Siiri-Liisi; Kivimäki, Petri; Nieminen, Anni I; Sarnola, Katriina; Therman, Sebastian; Tolmunen, Tommi, 2023, European journal of psychotraumatology, 14, 1, 2191396. A1 Journal article (refereed), original research

Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature

Koistinen, Ville; Kärkkäinen, Olli; Keski-Rahkonen, Pekka; Tsugawa, Hiroshi; Scalbert, Augustin; Arita, Masanori; Wishart, David; Hanhineva, Kati, 2023, Nature metabolism, 5, 351-354. B1 Non-refereed journal articles

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

Koponen, Markus; Rysä, Jaana; Ruotsalainen, Anna-Kaisa; Kärkkäinen, Olli; Juvonen, Risto O, 2023, Journal of nutrition and metabolism, 2023, 5599789. A1 Journal article (refereed), original research

Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

Haikonen, Retu; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati, 2022, Trends in endocrinology and metabolism, 33, 7, 463-480. A2 Review article, Literature review, Systematic review

Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field

Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati, 2022, Nature metabolism, 4, 4, 406-406. B1 Non-refereed journal articles

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Pessa-Morikawa, Tiina; Husso, Aleksi; Kärkkäinen, Olli; Koistinen, Ville; Hanhineva, Kati; Iivanainen, Antti; Niku, Mikael, 2022, Bmc microbiology, 22, 1, 46. A1 Journal article (refereed), original research

Microbiota-derived metabolites as drivers of gut–brain communication

Ahmed, Hany; Leyrolle, Quentin; Koistinen, Ville; Kärkkäinen, Olli; Layé, Sophie; Delzenne, Nathalie; Hanhineva, Kati, 2022, Gut microbes, 14, 1, e2102878. A2 Review article, Literature review, Systematic review

No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Jääskeläinen, Tiina; Kärkkäinen, Olli; Heinonen, Seppo; Hanhineva, Kati; Laivuori, Hannele, 2022, Pregnancy hypertension, 28, 74-80. A1 Journal article (refereed), original research

Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies

Voutilainen, Taija; Rysä, Jaana; Keski‐Nisula, Leea; Kärkkäinen, Olli, 2022, Alcoholism-clinical and experimental research, 46, 5, 797-808. A1 Journal article (refereed), original research

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Metabolomic insights: LC–MS profiling of human placental tissue from SSRI-treated pregnancies

Predictive value of alcohol use questionnaires for adverse pregnancy outcomes: Evidence from a Finnish birth cohort

Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth

Bipolar Disorder and Poisoning due to Medicines or Illegal Substances

Blueprint of the distinct metabolite profiles of healthy pig heart chambers

Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention

Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Long term safety of ADHD medication in patients with schizophrenia spectrum disorders

Longitudinal metabolic profiling of women using selective serotonin reuptake inhibitors during pregnancy

Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine

Metabolic profiles of meconium in preeclamptic and normotensive pregnancies

Metabolomics of aortic valve stenosis: Are aortic valve stenosis and sclerosis different diseases?

On Challenges of Studying the Complex Role of Bile Acids in Alcohol-Related Liver Disease

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study

Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder

Alkoholi (etyylialkoholi, etanoli)

Alkoholien toksikokinetiikka

Alkoholimyrkytyskuolemat ja alkoholille altistuminen

Alkoholin akuutit vaikutukset

Alkoholin farmakokinetiikka

Alkoholitoleranssi ja vieroitusoireet

An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight

Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

Etanoli ja sikiö

Etanolimyrkytys

Etanolin karsinogeeninen vaikutus

Etanolin krooniset haittavaikutukset

Etyleeniglykolimyrkytys

Metanolimyrkytys

Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Linking Hypothermia and Altered Metabolism with TrkB Activation

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

The associations between metabolic profiles and sexual and physical abuse in depressed adolescent psychiatric outpatients: an exploratory pilot study

Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature

Western Diet Decreases Hepatic Drug Metabolism in Male LDLr−/−ApoB100/100 Mice

Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease

Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Microbiota-derived metabolites as drivers of gut–brain communication

No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Self‐reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies