EINARI NISKANEN

University Lecturer

Group leader and university lecturer (bioinformatics)

Contact info

Organization

School of Medicine, Biomedicine

Email

einari.niskanen@uef.fi

Phone

+358 50 598 7492

Keywords

bioinformatics cellular stress coregulators glucocorticoid glucocorticoid receptor inflammatory response stress hormones transcription factors transcription regulation transcription repression

Research groups - UEF

Publications

Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells Oncogene 40 27: 4567-4579. 2021
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility Journal of steroid biochemistry and molecular biology 210: 105873. 2021
Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites Nucleic acids research 49 4: 1951-1971. 2021
Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Stress-induced nuclear condensation of NELF drives transcriptional downregulation Molecular cell 81 5: 1013-1026. 2021
Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation Oncogene 39: 2391-2407. 2020
Sutinen, Siiri; Niskanen, Einari. 2020. Histonien muokkaukset ja geenien säätely SOLUBIOLOGI 1: 12-21. 2020
Kaiser Manjur, ABM; Lempiäinen, Joanna K; Malinen, Marjo; Palvimo, Jorma J; Niskanen, Einari A. 2019. IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling Journal of steroid biochemistry and molecular biology 192: 105382. 2019
Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction Nature communications 10: 777. 2019
Lempiäinen Joanna K, Niskanen Einari A, Vuoti Kaisa-Mari, Lampinen Riikka E, Göös Helka, Varjosalo Markku, Palvimo Jorma J. 2017. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Molecular & Cellular Proteomics 16 8: 1462-1474. 2017
Niskanen Einari A, Palvimo Jorma J. 2017. Chromatin SUMOylation in heat stress : to protect, pause and organise?. BIOESSAYS 39 6: 1600263. 2017
Malinen Marjo, Niskanen Einari A, Kaikkonen Minna U, Palvimo Jorma J. 2016. Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-kB cistrome to reprogram the prostate cancer cell transcriptome. NUCLEIC ACIDS RESEARCH 45 2: 619-630. 2016
Mäntylä E, Salokas K, Oittinen M, Aho V, Mäntysaari P, Palmujoki L, Kalliolinna O, Ihalainen TO, Niskanen EA, Timonen J, Viiri K, Vihinen-Ranta M. 2016. Promoter-Targeted Histone Acetylation of Chromatinized Parvoviral Genome Is Essential for the Progress of Infection. JOURNAL OF VIROLOGY 90 8: 4059-4066. 2016
Toropainen Sari, Niskanen Einari A, Malinen Marjo, Sutinen Päivi, Kaikkonen Minna U, Palvimo Jorma J. 2016. Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets. Scientific Reports 6: 33510. 2016
Mäntylä Elina, Niskanen Einari A, Ihalainen Teemu O, Vihinen-Ranta Maija. 2015. Reorganization of nuclear pore complexes and the lamina in late-stage parvovirus infection. JOURNAL OF VIROLOGY Nov 15;89 22: 11706-11710. 2015
Niskanen Einari A, Malinen Marjo, Sutinen Päivi, Toropainen Sari, Paakinaho Ville, Vihervaara Anniina, Joutsen Jenny, Kaikkonen Minna U, Sistonen Lea, Palvimo Jorma J. 2015. Global SUMOylation on active chromatin is an acute heat stress response restricting transcription Genome biology 16: 153. 2015