Johanna Laakkonen
Academy Research Fellow
Faculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences
johanna.p.laakkonen@uef.fi | +358 50 305 8453
I’m an Academy Research Fellow, and PI of a junior research group focusing on Vascular Biology. The goal of our team is to improve therapeutics and diagnostics of cardiovascular diseases by understanding the biology behind the diseases. The main focus is in studying vascular anomalies and aortic aneurysms. Particularly genetics, cell-cell interaction and angioparacrine mediators are studied.
Research groups
Publications
25 items-
Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy
Sarin, Jaakko K; Kiema, Miika; Luoto, Emma-Sofia; Husso, Annastiina; Hedman, Marja; Laakkonen, Johanna P; Torniainen, Jari. 2023. Journal of surgical research. 287: 82-89 A1 Journal article (refereed), original research -
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms
Jauhiainen, Suvi; Kiema, Miika; Hedman, Marja; Laakkonen, Johanna P. 2022. Arteriosclerosis, thrombosis, and vascular biology. 42: 811-818 A2 Review article, Literature review, Systematic review -
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Kiema, Miika; Sarin, Jaakko K; Kauhanen, S Petteri; Torniainen, Jari; Matikka, Hanna; Luoto, Emma-Sofia; Jaakkola, Pekka; Saari, Petri; Liimatainen, Timo; Vanninen, Ritva; Ylä-Herttuala, Seppo; Hedman, Marja; Laakkonen, Johanna P. 2022. Frontiers in physiology. 13: A1 Journal article (refereed), original research -
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
Mushimiyimana, I; Niskanen. H; Beter, M; Laakkonen, JP; Kaikkonen, MU; Ylä-Herttuala, S; Laham-Karam, N. 2021. Nucleic acids research. 49: 8078-8096 A1 Journal article (refereed), original research -
Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation
Keränen, Sara; Suutarinen, Santeri; Mallick, Rahul; Laakkonen, Johanna P.; Guo, Diana; Pawlikowska, Ludmila; Jahromi, Behnam Rezai; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; Marchuk, Doug; Krings, Timo; Koivisto, Timo; Lawton, Michael; Radovanovic, Ivan; Kim, Helen; Faughnan, Marie E.; Frösen, Juhana. 2021. Acta neurochirurgica. 163: 2503-2514 A1 Journal article (refereed), original research -
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types
Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. 2021. Arteriosclerosis, thrombosis, and vascular biology. 41: 2149-2167 A1 Journal article (refereed), original research -
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. Biomolecules. 11: 452 A1 Journal article (refereed), original research -
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P. 2020. Angiogenesis. 2021; 24: 12-144 A1 Journal article (refereed), original research -
Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia
Laakkonen, Johanna P; Ylä-Herttuala, Seppo. Teoksessa: Nussinovitch, Udi, 2020. Emerging Technologies for Heart Diseases. Volume 2: Treatments for Myocardial Ischemia and Arrhythmias. s. 649-663. Academic press B2 Book section -
Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells
Hsin-Fu Liu, Oscar; Kiema, Miika; Beter, Mustafa; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Kaikkonen, Minna U. 2020. Arteriosclerosis, thrombosis, and vascular biology. 40: 2665-2677 A1 Journal article (refereed), original research