Jorma Palvimo
Professor
Professor
Professor of Medical Biochemistry
Director of the Master´s Degree Programme in Biomedicine
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
jorma.palvimo@uef.fi | +358 40 591 0693
Our research builds on our firm expertise in the steroid signaling and transcriptional regulation and our pioneering work on the SUMOylation of transcription factors and chromatin. Our current major goals are to:
– Identify the chromatin-bound proteins associated with the androgen receptor (AR) and the glucocorticoid receptor (GR) and reveal the role of SUMOylation in these associations.
– Discover novel means to target the AR and GR in castration resistant prostate cancer.
– Reveal the chromatin targets and mechanisms by which SUMOylation regulates gene networks and chromatin structure in cellular plasticity.
To address these aims, we will use cutting-edge genome- and proteome-wide tools, including GRO-seq, ChIP-seq, ChIP-SICAP and Turbo-ID proximity labeling, with human prostate cancer cell lines, mesenchymal stem cells and reprogrammable somatic cells as our main model systems.
We anticipate that our systemic studies and studies will provide us with novel leads for targeting steroid receptors. We also believe that our innovative and systematic approaches with multitalented research collaboration will provide us with novel SUMOylation targets and significant discoveries of the mechanisms by which SUMOylation regulates cellular plasticity and homeostasis. The results are likely to have translational potential in regenerative medicine and drug discovery for diseases, such as cancer.
Research groups
Projects
Publications
100/100 items-
Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer
Helminen, Laura; Huttunen, Jasmin; Tulonen, Melina; Aaltonen, Niina; Niskanen, Einari A; Palvimo, Jorma J; Paakinaho, Ville. 2023. Nucleic acids research. 2024; 52: 625-642 -
N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice
El Kharraz, Sarah; Dubois, Vanessa; Launonen, Kaisa-Mari; Helminen, Laura; Palvimo, Jorma J; Libert, Claude; Smeets, Elien; Moris, Lisa; Eerlings, Roy; Vanderschueren, Dirk; Helsen, Christine; Claessens, Frank. 2022. Endocrinology. 163: . bqac104 -
BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. Journal of steroid biochemistry and molecular biology. 210: 105873 -
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579 -
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Vandewalle, Jolien; Timmermans, Steven; Paakinaho, Ville; Vancraeynest, Lies; Dewyse, Liza; Vanderhaeghen, Tineke; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Eggermont, Melanie; Dewaele, Sylviane; Velho, Tiago R; Moita, Luis F; Weis, Sebastian; Sponholz, Christoph; van Grunsven, Leo A; Dewerchin, Mieke; Carmeliet, Peter; De Bosscher, Karolien; et al.; [incl. Palvimo, Jorma]. 2021. Cell metabolism. 33: 1763-1776.e5 -
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
Paakinaho, Ville; Palvimo, Jorma J. 2021. Endocrine-related cancer. 28: R231-R250 -
Reprogramming of glucocorticoid receptor function by hypoxia
Vanderhaeghen, Tineke; Timmermans, Steven; Watts, Deepika; Paakinaho, Ville; Eggermont, Melanie; Vandewalle, Jolien; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Dewaele, Sylviane; Vanden Berghe, Joke; Lemeire, Kelly; De Backer, Joey; Dirkx, Laura; Vanden Berghe, Wim; Caljon, Guy; Ghesquière, Bart; De Bosscher, Karolien; Wielockx, Ben et al [incl. Palvimo, Jorma J]. 2021. Embo reports. 2022; 23: e53083 -
SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. Nucleic acids research. 49: 1951-1971 -
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Molecular cell. 81: 1013-1026 -
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation
El Kharraz, Sarah; Dubois, Vanessa; Royen, Martin E; Houtsmuller, Adriaan B; Pavlova, Ekatarina; Atanassova, Nina; Nguyen, Tien; Voet, Arnout; Eerlings, Roy; Handle, Florian; Prekovic, Stefan; Smeets, Elien; Moris, Lisa; Devlies, Wout; Ohlsson, Claes; Poutanen, Matti; Verstrepen, Kevin J; Carmeliet, Geert; Launonen, Kaisa-Mari; Helminen, Laura et al [incl. Palvimo, Jorma J]. 2021. Embo reports. 22: e52764