Jouko Vepsäläinen

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Hyvärinen, Eelis; Solje, Eino; Vepsäläinen, Jouko; Kullaa, Arja; Tynkkynen, Tuulia. 2023. Metabolites. 13:

Valorization potential of the aqueous products from hydrothermal liquefaction and stepwise slow pyrolysis of wood bark and hemp hurds with yields and product comparison

Jokinen, Noora; Eronen, Eemeli; Salami, Ayobami; Hyttinen, Marko; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo; Tomppo, Laura. 2023. Bioresource technology reports. 21: . 101385

Effects of tree harvesting time and tannin cold/hot-water extraction procedures on the performance of spruce tannin biocoagulant for water treatment

Bello, Adedayo; Bergmann, Ulrich; Vepsäläinen, Jouko; Leiviskä, Tiina. 2022. Chemical engineering journal. 449:

Functionalized nanoporous silicon for extraction of Sc from a leach solution

Rahmani, Arezoo; Thapa, Rinez; Aalto, Juha Matti; Turhanen, Petri; Vepsäläinen, Jouko; Lehto, Vesa Pekka; Riikonen, Joakim. 2022. Hydrometallurgy. 211: . 105866

Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X-ray Fluorescence (pXRF) System

Tiihonen, Tommi E; Nissinen, Tuomo J; Turhanen, Petri A; Vepsäläinen, Jouko J; Riikonen, Joakim; Lehto, Vesa Pekka. 2022. Analytical chemistry. 94: 11739-11744

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

Hyvönen, Mervi T.; Smirnova, Olga A.; Mitkevich, Vladimir A.; Tunitskaya, Vera L.; Khomutov, Maxim; Karpov, Dmitry S.; Korolev, Sergey P.; Häkkinen, Merja R.; Pietilä, Marko; Gottikh, Marina B.; Vepsäläinen, Jouko; Alhonen, Leena; Makarov, Alexander A.; Kochetkov, Sergey N.; Wallace, Heather M.; Keinänen, Tuomo A.; Khomutov, Alex R.. 2022. International journal of molecular sciences. 23:

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Hyvönen, Mervi T; Khomutov, Maxim; Vepsäläinen, Jouko; Khomutov, Alex R; Keinänen, Tuomo A. 2021. Biomolecules. 11: 707

A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots

Salami, Ayobami; Heikkinen, Jorma; Tomppo, Laura; Hyttinen, Marko; Kekäläinen, Timo; Jänis, Janne; Vepsäläinen, Jouko; Lappalainen, Reijo. 2021. Molecules. 26: 3167

Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture

Kuittinen, Suvi; Hietaharju, Jenna; Kupiainen, Laura; Hassan, Md. Kamrul; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Kangas, Jani; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari. 2021. Journal of cleaner production. 293: 126088

Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria

Virpiranta, Hanna; Taskila, Sanna; Leiviskä, Tiina; Vepsäläinen, Jouko; Rämö, Jaakko; Tanskanen, Juha. 2021. Journal of water and climate change. 12: 3544-3557

Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel

Nissinen, Samuli I; Venäläinen, Markus; Kumpulainen, Pekka; Roine, Antti; Häkkinen, Merja R; Vepsäläinen, Jouko; Oksala, Niku; Rantanen, Tuomo. 2021. Cancer control. 29: 1-9

Effect of solvent mixture pretreatment on sugar release from short-rotation coppice Salix schwerinii for biobutanol production

Yang, Ming; Guo, Xiaojun; Liu, Guozhen; Nan, Yufei; Zhang, Junhua; Noyazzesh, Hossain; Kuittinen, Suvi; Vepsäläinen, Jouko; Pappinen, Ari. 2021. Bioresource technology. 344: 126262

Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus

Lehtiniemi, Maiju; Hartikainen, Samuel; Turja, Raisa; Lehtonen, Kari K.; Vepsäläinen, Jouko; Peräniemi, Sirpa; Leskinen, Jari; Setälä, Outi. 2021. Marine pollution bulletin. 173: 113103

Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds

Verkasalo, Erkki; Möttönen, Veikko; Roitto, Marja; Vepsäläinen, Jouko; Kumar, Anuj; Ilvesniemi, Hannu; Siwale, Workson; Julkunen-Tiitto, Riitta; Raatikainen, Olavi; Sikanen, Lauri. 2021. Forests. 12: 192

Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption

Haluska, Ondrej; Rahmani, Arezoo; Salami, Ayobami; Turhanen, Petri; Vepsäläinen, Jouko; Lappalainen, Reijo; Lehto, Vesa-Pekka; Riikonen, Joakim. 2021. Microporous and mesoporous materials. 324: 111294

Recovery of uranium with bisphosphonate modified mesoporous silicon

Thapa, Rinez; Rahmani, Arezoo; Turhanen, Petri; Taskinen, Antti; Nissinen, Tuomo; Neitola, Raisa; Vepsäläinen, Jouko; Lehto, Vesa-Pekka; Riikonen, Joakim. 2021. Separation and purification technology. 272: 118913

Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms

Hagner, Marleena; Räty, Mari; Nikama, Johanna; Rasa, Kimmo; Peltonen, Sari; Vepsäläinen, Jouko; Keskinen, Riikka. 2021. Science of the total environment. 784: 147139

Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams

Sandar, Sandra; Yang, Ming; Turunen, Ossi; Vepsäläinen, Jouko; Pappinen, Ari; Kuittinen, Suvi. 2020. Bioresources. 15: 9265-9290

Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing

Salami, Ayobami; Raninen, Kaisa; Heikkinen, Jorma; Tomppo, Laura; Vilppo, Teemu; Selenius, Mikko; Raatikainen, Olavi; Lappalainen, Reijo; Vepsäläinen, Jouko. 2020. Industrial crops and products. 155: 112760

Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process

Salami, A; Vilppo, T; Pitkänen, S; Weisell, J; Raninen, K; Vepsäläinen, J; Lappalainen, R. 2020. Scientific African. 8: 1-13

Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent

Szlachta, Malgorzata; Neitola, Raisa; Peräniemi, Sirpa; Vepsäläinen, Jouko. 2020. Separation and purification technology. 253: 117493

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsäläinen, Jouko; Khomutov, Alex. 2020. Communications chemistry. 3: 121

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Hyvönen, Mervi; Keinänen, Tuomo; Nuraeva, Gulgina; Yanvarev, Dmitry; Khomutov, Maxim; Khurs, Elena; Kochetkov, Sergey; Vepsäläinen, Jouko; Zhgun, Alexander; Khomutov, Alex. 2020. Biomolecules. 10: 406

Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum

Hagner, Marleena; Lindqvist, Bengt; Vepsäläinen, Jouko; Samorì, Chiara; Keskinen, Riikka; Rasa, Kimmo; Hyvönen, Terho. 2020. Environmental technology and innovation. 20: 101154

Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils

Mohsin, Muhammad; Kuittinen, Suvi; Abdus Salam, Mir Md; Peräniemi, Sirpa; Laine, Saila; Pulkkinen, Pertti; Kaipiainen, Erik; Vepsäläinen, Jouko; Pappinen, Ari. 2019. Journal of geochemical exploration. 205: 106335

Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation

Yang, Ming; Wang, Jia; Nan, Yufei; Zhang, Junhua; Li, Liyun; Liu, Guozhen; Vepsäläinen, Jouko; Kuittinen, Suvi; Pappinen, Ari. 2019. Rsc advances. 9: 33755-33760

Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach

Turhanen, Petri; Leppänen, Jukka; Vepsäläinen, Jouko J. 2019. ACS omega. 4: 8974-8984

Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti

Turunen, Kaisa; Antikainen, Eero; Huotari-Halkosaari, Taija; Ikonen, Jenni; Janhunen, Maarit; Lahtinen, Tatu; Lerssi, Jouni; Miettinen, Ilkka; Meriläinen, Päivi; Niittynen, Marjo; Pullinen, Arto; Reijonen, Tero; Raatikainen, Mika; Sonninen, Jari; Torvinen, Olli; Vauhkonen, Marko; Vepsäläinen, Jouko. 2019. GTK:n työraportti. .

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Tynkkynen, T; Wang, Q; Ekholm, J; Anufrieva, O; Ohukainen, P; Vepsäläinen, J; Männikkö, M; Keinänen-Kiukaanniemi, S; Holmes, MV; Goodwin, M; Ring, S; Chambers, JC; Kooner, J; Järvelin, MR; Kettunen, J; Hill, M; Davey Smith, G; Ala-Korpela, M. 2019. International journal of epidemiology. 48: 978-993

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

Khomutov, Maxim; Hyvönen, Mervi T; Simonian, Alina; Formanovsky, Andrey A; Mikhura, Irina V; Chizhov, Alexander O; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R. 2019. Journal of medicinal chemistry. 62: 11335-11347

Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf

Kuittinen, Suvi; Yang, Ming; Kaipiainen, Erik; Villa, Aki; Keinänen, Markku; Vepsäläinen, Jouko; Pappinen, Ari. 2018. Bioresources. 13: 5225-5240

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase

Khomutov, Maxim A; Hyvönen, Mervi T; Simonian, Alina R; Weisell, Janne; Vepsäläinen, Jouko; Alhonen, Leena; Kochetkov, Sergey N; Keinänen, Tuomo A; Khomutov, Alex R. 2018. Mendeleev communications. 28: 479-481

Altered polyamine profiles in colorectal cancer

Venäläinen, Markus K; Roine, Antti N; Häkkinen, Merja R; Vepsäläinen, Jouko J; Kumpulainen, Pekka S; Kiviniemi, Mikko S; Lehtimäki, Terho; Oksala, Niku K; Rantanen, Tuomo K. 2018. Anticancer research. 38: 3601-3607

Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement

Lehtovirta, L; Reito, A; Parkkinen, J; Peräniemi, S; Vepsäläinen, J; Eskelinen, A. 2018. PLoS ONE. 13: e0197614

Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration

Ucal, Sebahat; Häkkinen, Merja R; Alanne, Aino-Liisa; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Hyvönen, Mervi T. 2018. Biochemical journal. 475: 663-676

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Keinänen, Tuomo A; Grigorenko, Nikolay; Khomutov, Alex R; Huang, Qingqiu; Uimari, Anne; Alhonen, Leena; Hyvönen, Mervi T; Vepsäläinen, Jouko. 2018. Bioscience reports. 38: BSR20180527

Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production

Yang, Ming; Xu, Minyuan; Nan, Yufei; Kuittinen, Suvi; Hassan, Md Kamrul; Vepsäläinen, Jouko; Xin, Donglin; Zhang, Junhua; Pappinen, Ari. 2018. Bioresource technology. 257: 113-120

Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement

Yang Ming, Kuittinen Suvi, Vepsäläinen Jouko, Zhang Junhua, Pappinen Ari. 2017. Bioresource technology. 243: 126-134

On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge

Khomich OA, Yanvarev DV, Novikov RA, Kornev AB, Puljulla E, Vepsäläinen J, Khomutov AR, Kochetkov SN. 2017. Molecules. 22: e1040

Urinary Polyamines as Biomarkers for Ovarian Cancer

Niemi Riikka Johanna, Roine Antti N, Häkkinen Merja R, Kumpulainen Pekka S, Keinänen Tuomo A, Vepsäläinen Jouko J, Lehtimäki Terho, Oksala Niku K, Mäenpää Johanna U. 2017. International journal of gynecological cancer. 27: 1360-1366

Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids

Khomutov MA, Formanovsky AA, Mikhura IV, Vepsäläinen Jouko, Kochetkov SN, De Biase D, Khomutov AR. 2016. Russian journal of bioorganic chemistry. 42: 672-676

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase

Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN. 2016. Data in brief. 8: 1157-1167

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Yanvarev DV, Korovina AN, Usanov NN, Khomich OA, Vepsäläinen Jouko, Puljula Elina, Kukhanova MK, Kochetkov SN. 2016. Biochimie. 127: 153-162

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase

Khomutov MA, Simonian AR, Weisell J, Vepsäläinen J, Kochetkov SN. 2016. Russian journal of bioorganic chemistry. 42: 415-422

Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach

Turhanen Petri, Vepsäläinen Jouko. 2016. Rsc advances. 6: 15937-15940

Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

Puljula Elina, Vepsäläinen Jouko, Turhanen Petri. 2016. Beilstein journal of organic chemistry. 12: 2145-2149

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

Hyvönen Mervi T, Ucal Sebahat, Pasanen Markku, Peräniemi Sirpa, Weisell Janne, Khomutov Maxim, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2016. Biochemical journal. 473: 1433-1441

A powerful tool for acid catalyzed organic addition and substitution reactions

Turhanen Petri, Vepsäläinen Jouko. 2015. Rsc advances. 5: 26218-26222

Advanced material and approach for metal ions removal from aqueous solutions

Turhanen Petri A, Vepsäläinen Jouko J, Peräniemi Sirpa. 2015. Scientific reports. 5: 8992

Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid

Laakso Mikko P, Jukarainen Niko M, Vepsäläinen Jouko. 2015. Journal of neurology neurosurgery and psychiatry. 86: 1286-1290

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

Hyvönen Mervi T, Khomutov Maxim, Petit Marine, Weisell Janne, Kochetkov Sergey N, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A. 2015. Acs chemical biology. 10: 1417-1424

Enantioselective synthesis of (R)- and (S)-3-methylspermidines

Khomutov MA, Keinanen Tuomo A, Hyvonen Mervi T, Weisell Janne, Vepsalainen Jouko, Alhonen Leena, Kochetkov SN, Khomutov AR. 2015. Russian journal of bioorganic chemistry. 41: 548-553

Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation

Yang Ming, Zhang Junhua, Kuittinen Suvi, Vepsäläinen Jouko, Soininen Pasi, Keinänen Markku, Pappinen Ari. 2015. Bioresource technology. 189: 131-137

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Vepsäläinen Jouko, Pasanen Markku, Rahnasto-Rilla Minna. 2015. Chemical research in toxicology. 28: 702-710

Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives

Ucal Sebahat, Khomutov Alex R, Häkkinen Merja R, Turhanen Petri A, Vepsäläinen Jouko J, Weisell Janne. 2015. Arkivoc. 2015: 42-49

Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters

Puljula Elina, Turhanen Petri, Vepsäläinen Jouko, Monteil Maelle, Lecouvey Marc, Weisell Janne. 2015. Acs medicinal chemistry letters. 6: 397-401

Synthesis of biologically active analogues of spermine and spermidine

Khomutov Maxim, Keinanen Tuomo A., Hyvonen Mervi T., Alhonen Leena, Vepsalainen Jouko, Khomutov Alex R.. 2015. Amino acids

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Weisell Janne, Vepsäläinen Jouko, Turhanen Petri A. 2015. Beilstein journal of organic chemistry. 11: 2189-2193

Urinary acetylated polyamines in ovarian cancer

Mäenpää Johanna Unelma, Niemi Riikka, Roine Antti, Häkkinen Merja, Kumpulainen Pekka, Keinänen Tuomo, Vepsäläinen Jouko, Lehtimäki Terho, Oksala Niku. 2015. Journal of clinical oncology

Uusi menetelmä ja uusi katalyyttinen järjestelmä selektiivisiin orgaanisiin additio- ja substituutioreaktioihin

Vepsäläinen Jouko, Turhanen Petri. 2015.

Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence

Castro-Oropeza R, Pino-Ángeles A, Khomutov MA, Urdiales JL, Moya-García AA, Vepsäläinen J, Persson L, Sarabia F, Khomutov A, Sánchez-Jiménez F. 2014. Amino acids. 46: 621-631

Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques

Julkunen-Tiitto Riitta, Nenadis Nikolaos, Neugart Susanne, Robson Matthew, Agati Giovanni, Vepsäläinen Jouko, Zipoli Gaetano, Nybakken Line, Winkler Barbro, Jansen Marcel AK. 2014. Phytochemistry reviews. 2015; 14: 273-297

Bisphosphonates: How does the structure affect the ability to bind to hydroxyapatite?

Elina Puljula, Aino-Liisa Alanne, Petri Turhanen, Jouko Vepsäläinen, Janne Weisell. 2014.

Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production

Yang Ming, Kuittinen Suvi, Zhang Junhua, Vepsäläinen Jouko, Keinänen Markku, Pappinen Ari. 2014. Bioresource technology. 2015; 179: 128-135

Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study

Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K. 2014. Journal of urology. 192: 230-235

Eletroninen nenä havaitsee eturauhassyövän virtsasta [Detection of prostate cancer by an eletronic nose: a proof-of-principle study. J Urol, julkaistu verkossa 25.2.2014]

Roine Antti, Veskimäe Erik, Tuokko Antti, Kumpulainen Pekka, Koskimäki Juha, Keinänen Tuomo A, Häkkinen Merja R, Vepsäläinen Jouko, Paavonen Timo, Lekkala Jukka, Lehtimäki Terho, Tammela Teuvo L, Oksala Niku K. 2014. Duodecim. 130: 53

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. 2014. Biochemistry: moscow. 2013; 78: 1431-1446

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Chemical research in toxicology. 27: 1950-1957

Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. 2014. Phytochemical analysis. 25: 220-228

Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS

Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2014. Food chemistry. 165: 499-505

Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme

Keinanen TA, Hyvonen T, Vepsalainen J, Alhonen L, Khomutov AR, Janne J. 2014. Russian journal of bioorganic chemistry. 40: 155-161

The use of (green field) biomass pretreatment liquor for fermentative butanol production and the catalytic oxidation of biobutanol

Yang Ming, Kuittinen Suvi, Keinänen Markku, Vepsäläinen Jouko, Romar Henrik, Tynjälä Pekka, Lassi Ulla, Pappinen Ari. 2014. Chemical engineering research and design. 92: 1531-1538

Uraanin ja muiden raskasmetallien poistaminen vedestä

Vepsäläinen Jouko. 2014. Ympäristö ja terveys. 45: 72-76

A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens

Alanne Aino-Liisa, Peräniemi Sirpa, Turhanen Petri, Tuomainen Marjo, Vepsäläinen Jouko, Tervahauta Arja. 2013. Chemosphere. 2014:95: 566-571

A novel bisphosphonate-based solid phase method for effective removal of chromium(III) from aqueous solutions and tannery effluents

Alanne Aino-Liisa, Tuikka Matti, Tõnsuaadu Kaia, Ylisirniö Markku, Hämäläinen Lea, Turhanen Petri, Vepsäläinen Jouko, Peräniemi Sirpa. 2013. Rsc advances. 3: 14132-14138

An Insoluble Bisphosphonate as a Metal Collector - an Innovative Solution to the Waste Water Problems of the Mining Industry

Aino-Liisa Alanne, Petri Turhanen, Janne Kankkunen, Sirpa Peräniemi, Jouko Vepsäläinen. 2013.

An in vitro method for determining bisphosphonate-binding to hydroxyapatite by 31P NMR

Sankala, E., Weisell, J. and Vepsäläinen, J. 2013.

An in vitro method for determining bisphosphonate-binding to hydroxyapatite by 31P NMR

Sankala, E., Alanne, A.-L., Turhanen, P., Weisell, J. and Vepsäläinen.. 2013.

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS

Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 941: 81-89

Charge deficient analogues of the natural polyamines

Weisell Janne, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A, Khomutov Alex R. 2013. Current pharmaceutical design. 2014:20: 262-277

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

Huttunen Kristiina M, Leppänen Jukka, Laine Krista, Vepsäläinen Jouko, Rautio Jarkko. 2013. European journal of pharmaceutical sciences. 49: 624-628

Effect of bisphosphonates on metal accumulation in the metal hyperaccumulator plan Noccaea caerulescens

Alanne A, Tuomainen M, Turhanen P, Peräniemi S, Vepsäläinen J, Kärenlmpi S, Tervahauta A. 2013.

First bisphosphonate hydrogelators: potential composers of biocompatible gels

Alanne Aino-Liisa, Lahtinen Manu, Löfman Miika, Turhanen Petri, Kolehmainen Erkki, Vepsäläinen Jouko, Sievänen Elina. 2013. Journal of materials chemistry. b. 1: 6201-6212

Method for collecting metals

Turhanen Petri, Peräniemi Sirpa, Vepsäläinen Jouko. 2013.

Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity

Meinander Kristian, Weisell Janne, Pakkala Miikka, Tadd Andrew C, Hekim Can, Kallionpää Roope, Widell Kim, Stenman Ulf-Håkan, Koistinen Hannu, Närvänen Ale, Vepsäläinen Jouko, Luthman Kristina, Wallén Erik AA. 2013. Medchemcomm. 4: 549-553

Selective regulation of polyamine metabolism with methylated polyamine analogues

Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Vepsäläinen Jouko, Khomutov Alex R. 2013. Amino acids. 2014:46: 605-620

Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives

Agapkina Julia, Yanvarev Dmitry, Anisenko Andrey, Korolev Sergey, Vepsäläinen Jouko, Kochetkov Sergey, Gottikh Marina. 2013. European journal of medicinal chemistry. 2014:73: 73-82

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Hyvönen Mervi T, Koponen Taina, Weisell Janne, Pietilä Marko, Khomutov Alex R, Vepsäläinen Jouko, Alhonen Leena, Keinänen Tuomo A. 2013. Biochemical journal. 453: 467-474

Tautomeric populations of the charged species of 1,12-diamino-3,6,9-triazadodecane (SpmTrien) studied with computer simulations and cluster expansions

Weisell Janne, Vepsäläinen Jouko, Peräkylä Mikael. 2013. Journal of physical organic chemistry. 26: 360-366

The selective stepwise chemical hydrolysis of alkylcarbonate groups from novel mixed alkylcarbonate trialkyl ester derivatives of etidronic acid

Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J. 2013. Rsc advances. 3: 2417-2421

99mTc-labeled partial esters of etidronic acid and their biodistribution in healthy mice

Sankala E, Turhanen P, Weisell J, Monteil M, Lecouvey M, Huhtala T, Närvänen A, Vepsäläinen J. 2012.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells

Smirnova Olga A, Isaguliants Maria G, Hyvonen Mervi T, Keinanen Tuomo A, Tunitskaya Vera L, Vepsalainen Jouko, Alhonen Leena, Kochetkov Sergey N, Ivanov Alexander V. 2012. Biochimie. 94: 1876-1883

Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose

Roine Antti, Tolvanen Mikko, Sipiläinen Miki, Kumpulainen Pekka, Helenius Merja A, Lehtimäki Terho, Vepsäläinen Jouko, Keinänen Tuomo A, Häkkinen Merja R, Koskimäki Juha, Veskimäe Erik, Tuokko Antti, Visakorpi Tapio, Tammela Teuvo L, Sioris Thanos, Paavonen Timo, Lekkala Jukka, Helle Hannu, Oksala Niku K. 2012. Future oncology. 8: 1157-1165

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A

Hyvönen Mervi T, Keinänen Tuomo A, Khomutov Maxim, Simonian Alina, Vepsäläinen Jouko, Park Jong H, Khomutov Alex R, Alhonen Leena, Park Myung H. 2012. Amino acids. 42: 685-695

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

Huttunen Kristiina M, Leppänen Jukka, Vepsäläinen Jouko, Sirviö Jouni, Laine Krista, Rautio Jarkko. 2012. Journal of pharmaceutical sciences. 101: 2854-2860

Metabolism of bilirubin by human cytochrome P450 2A6

Abu-Bakar A'edah, Arthur Dionne M, Wikman Anna S, Rahnasto Minna, Juvonen Risto O, Vepsäläinen Jouko, Raunio Hannu, Ng Jack C, Lang Matti A. 2012. Toxicology and applied pharmacology. 261: 50-58

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N1-acetyltransferase and thialysine acetyltransferase

Hyvönen Mervi T, Weisell Janne, Khomutov Alex, Alhonen Leena, Vepsäläinen Jouko, Keinänen Tuomo A. 2012. Drug metabolism and disposition. 2013:41: 30-32

Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS

Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Amino acids. 42: 451-460

Preparation of mixed trialkyl alkylcarbonate derivates of etidronic acid via an unusual route

Turhanen Petri A, Weisell Janne, Vepsäläinen Jouko J. 2012. Beilstein journal of organic chemistry. 8: 2019-2024

Spectral analysis of ethenylidene bisphosphonates

Sankala E, Chmielewska E, Vepsäläinen J. 2012.

Synthesis of novel bisphosphonate polyamine conjugates and their affinity to hydroxyapatite

Sankala Elina, Weisell Janne M, Huhtala Tuulia, Närvänen Ale T.O, Vepsäläinen Jouko J. 2012. Arkivoc. 2012: 233-241

Systematic study of the physicochemical properties of a homologous series of aminobisphosphonates

Alanne Aino-Liisa, Hyvönen Helena, Lahtinen Manu, Ylisirniö Markku, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko. 2012. Molecules. 17: 10928-10945

The combined use of constrained total-line-shape 1H NMR and LC-MS/MS for quantitative analysis of bioactive components in yellow onion

Soininen Tuula H, Jukarainen Niko, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2012. Journal of food composition and analysis. 25: 208-214

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase

Hyvönen Mervi T, Uimari Anne, Vepsäläinen Jouko, Khomutov Alex R, Keinänen Tuomo A, Alhonen Leena. 2012. Amino acids. 42: 485-493

A novel strategy for the synthesis of enzymatically stable biotin-DOTA conjugates for in vivo use

Turhanen Petri A, Weisell Janne, Lehtolainen-Dalkilic Pauliina, Määttä Ann-Marie, Vepsäläinen Jouko, Närvänen Ale. 2011. Medchemcomm. 2: 886-888

Alkylaminobisphosphonates: Synthesis, characterization and determination of pKa-values

Saari, A-L.; Ylisirniö, M.; Lahtinen, M.; Hyvönen, H.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S. and Vepsäläinen, J.. 2011.

Alkylaminobisphosphonates: Synthesis, characterization and determination of pKa-values

Saari, A-L.; Ylisirniö, M.; Lahtinen, M.; Hyvönen, H.; Turhanen, P.; Kolehmainen, E.; Peräniemi, S. and Vepsäläinen, J.. 2011.

Complex N-Acetylation of Triethylentetramine

Marc Cerrada-Gimenez, Janne Weisell, Mervi T. Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, and Tuomo A. Keinänen. 2011. Drug metabolism and disposition. 39: 2242-2249

Methylated polyamines as research tools

Khomutov Alex R, Weisell Janne, Khomutov Maxim A, Grigorenko Nikolay A, Simonian Alina R, Häkkinen Merja R, Keinänen Tuomo A, Hyvönen Mervi T, Alhonen Leena, Kochetkov Sergey N, Vepsäinen Jouko. Teoksessa: Pegg, A.E. ja Casero, R.A. Jr.(toim.) , 2011. Polyamines. Methods and Protocols. s. 449-461. Springer

Novel metabolically stable functionally active mimetic of spermidine

Khomutov MA, Hyvönen MT, Simonian AR, Vepsäläinen J, Alhonen L, Kochetkov SN, Keinänen TA. 2011. Russian journal of bioorganic chemistry. 37: 253-258

Novel polyamine bisphosphonates: synthesis, radiolabelling and affinity to hydroxyapatite

Sankala E, Vepsäläinen J, Närvänen A, Weisell J. 2011.

Novel polyamine bisphosphonates: synthesis, radiolabelling and affinity to hydroxyapatite

Sankala E, Vepsäläinen J, Närvänen A, Weisell J. 2011.

Quantitative Analysis of Onion Metabolic Composition Based on NMR Spectroscopy

Jukarainen Niko, Soininen Tuula, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko. 2011.

Quantitative analysis of onion species metabolites by NMR spectroscopy

Soininen, T., Jukarainen, N., Julkunen-Tiitto, R., Karjalainen, R., Vepsäläinen, J.. 2011.

Synthesis, Characterization and determination of pKa-values of alkylaminobisphosphonates

Saari Aino-Liisa, Ylisirniö, Markku, Lahtinen Manu, Hyvönen Helena, Turhanen Petri, Kolehmainen Erkki, Peräniemi Sirpa, Vepsäläinen Jouko. 2011.

The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism

Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, and Alex R. Khomutov. 2011. Journal of medicinal chemistry. 54: 4611-4618

A novel and efficient method to prepare 2-aryltetrahydrofuran-2-ylphosphonic acids

Komissarov VV, Kritzyn AM & Vepsäläinen J. 2010. Beilstein journal of organic chemistry. 6: 1-5

Acute Pancreatitis Induced by Activated Polyamine Catabolism is Associated with Coagulopathy: Effect of a-Methylated Polyamines Analogs on Haemostasis

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko NA, Khomutov AR, Vepsäläinen J & Alhonen L. 2010. Pancreatology. 10: 208-221

Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products

Kunnas-Hiltunen S, Haukka M, Vepsäläinen JJ & Ahlgrén M. 2010. Dalton transactions. 39: 5310-5318

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage

Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA & Thomas TJ. 2010. Biomacromolecules. 11: 97-105

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases

Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Amino acids. 38: 369-381

Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3 stimulating peptide B-2.

Pakkala M, Weisell J, Hekim C, Vepsäläinen J, Wallen E, Stenman U-H, Koistinen H, Närvänen A.. 2010. Amino acids. 39: 233-236

Novel convenient synthesis of biologically active esters of hydroxylamine

Maxim A. Khomutov, Swati Mandal, Janne Weisell, Neiha Saxena, Alina R. Simonian, Jouko Vepsalainen, Rentala Madhubala, Sergey N. Kochetkov. 2010. Amino acids. 38: 509-517

Novel isosteric charge-deficient spermine analogue-1,12- diamino-3,6,9-triazadodecane: synthesis, pKa measurement and biological activity

Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR & Soininen P. 2010. Amino acids. 38: 501-507

Organic-Inorganic Hybrid Materials: Synthesis, X-ray Diffraction Study and Characterisations of Manganese, Coboalt and Copper Complexes of Modified Bis(phosphonates)

Kunnas-Hiltunen S, Laurila E, Haukka M, Vepsäläinen JJ & Ahlgrén M. 2010. Zeitschrift fur anorganische und allgemeine chemie. 636: 710-720

Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA et al. 2010. Journal of medicinal chemistry. 53: 5738-5748

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage

Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA & Alhonen L. 2010. Amino acids. 38: 575-581

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography

Huttunen KM, Rautio J, Leppänen J, Vepsäläinen J, Keski-Rahkonen P. 2009. Journal of pharmaceutical and biomedical analysis. 50: 469-474

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA. 2009. Biochemical journal. 422: 321-328

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Vepsalainen J, Alhonen L, Janne J. 2009. MOLEKULIARNAIA BIOLOGIIA [MOSKVA]. 43: 274-285

Poly[(acetone)tetraaqua[my6-ethyl(dichloromethylene)diphosphonato]-[my5-ethyl (dichloromethylene)-diphosphonato]tribarium(II)]

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2009. Acta crystallographica section C : crystal structure communications. C65: m165-m167

Poly[[my-aqua-aqua[myy4-ethyl(dichloromethylene)diphosphonato]sesquicalcium(II)] acetone hemisolvate 4.5-hydrate]

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2009. Acta crystallographica section E : structure reports online. E65: m436-m437

Syntheses, X-ray diffraction study and characterisations of Ni an Zn complexes of clodronic acid and its dibenzoyl derivate

Kunnas-Hiltunen S, Haukka M, Vepsäläinen J, Ahlgrén M. 2009. European journal of inorganic chemistry. : 5335-5345

Synthesis of novel deuterium labelled derivates of N-alkylated polyamines

Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Tetrahedron. 65: 547-562

Synthesis of phenyl substituted bisphosphonates and crystal structures and characterization of Cd complexes of (dichloromethylene)bisphosphonic acid phenyl and alkyl ester derivatives

Jokiniemi J, Vepsäläinen J, Nätkinniemi H, Peräniemi S, Ahlgrén M. 2009. Crystengcomm. : 2431-2440

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Huttunen KM, Mannila A, Laine K, Kemppainen E, Leppänen J, Vepsäläinen J, Järvinen T, Rautio J. 2009. Journal of medicinal chemistry. 52: 4142-4148

X-ray diffraction study of bisphosphonate metal complexes: Mg, Sr and Ba complexes of (dichloromethylene)bisphosphonic acid P,P'-dibenzoyl anhydride

Kunnas-Hiltunen S, Matilainen M, Vepsäläinen JJ, Ahlgrén M. 2009. Polyhedron. 28: 200-204

catena-Poly[[diaquacadmium(II)]-mu-(methyl morpholino dicholromethylene-disphosphonato)-kappa3O,O':O''-[tetraaqua-cadmium(II)-mu-(methyl morpholino dichloromethylenediphosphonato)-kappa3O:O',O'']

Jokiniemi J, Vepsäläinen J, Ahlgrén M. 2009. Acta crystallographica section E : structure reports online. : M600-M601

A structural study of alkaline earth metal complexes of (dicholoromethylene)bisphosphonic acid P-morpholinium- and P-pyrrolidinium-P'-methyl esters

Jokiniemi J, Peräniemi S, Vepsäläinen J, Ahlgrén M. 2008. Crystengcomm. : 1011-1017

Ex vivo evaluation of N(3-[18F]fluoroproponyl9-2beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane in rats

Koivula T, Marjamäki P, Haaparanta M, Fagerholm V, Grönroos T, Lipponen T, Perhola O, Vepsäläinen J, Solin O. 2008. Nuclear medicine and biology. : 177-183

Novel agmatine analogue, gamma-quanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels

Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R. 2008. Biochemical and biophysical research communications. 375: 168-172

Quantification of 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis

Jukarainen NM, Korhonen S-P, Laakso MP, Korolainen MA, Niemitz M, Soininen PP, Tuppurainen K, Vepsäläinen J, Pirttilä T, Laatikainen R, Pirttilä T. 2008. Metabolomics. 4: 150-160

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Journal of pharmaceutical and biomedical analysis. 48: 414-421

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

Kumpulainen H, Järvinen T, Mannila A, Leppänen J, Nevalainen T, Mäntylä A, Vepsäläinen J, Rautio J. 2008. European journal of pharmaceutical sciences. 34: 110-117

Towards metformin prodrugs

Huttunen KM, Leppänen J, Kemppainen E, Palonen P, Rautio J, Järvinen T, Vepsäläinen J. 2008. Synthesis: stuttgart. : 3619-3624

Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions

Turhanen PA, Vepsäläinen JJ. 2008. Beilstein journal of organic chemistry. 4:

2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JAM, Forsberg MM, Männistö PT, Wallén EAA. 2007. Bioorganic and medicinal chemistry. 15: 2024-2031

A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterfied derivatives

Turhanen PA, Demadis KD, Peräniemi S, Vepsäläinen JJ. 2007. Journal of organic chemistry. 72: 1468-1471

Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors

Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman U-H, Vepsäläinen J, Närväinen A. 2007. Journal of peptide science. 13: 348-353

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J. 2007. Mini-reviews in medicinal chemistry. 7: 813-820

Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 45: 625-634

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase

Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J. 2007. Nucleosides nucleotides and nucleic acids. 26: 1245-1248

Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality

Huttunen KM, Mähönen N, Leppänen J, Vepsäläinen J, Juvonen RO, Raunio H, Kumpulainen H, Järvinen T, Rautio J. 2007. Pharmaceutical research. 24: 679-687

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis

Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig K-H, Jänne J, Alhonen L. 2007. Amino acids. 33: 323-330

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J. 2007. Journal of biological chemistry. 282: 34700-34706

Structural study of metal complexes of bisphosphonate amide ester: copper, magnesium, zinc and cadmium complexes of (dichloromethylene)bisphosphonic acid P-piperidinium-P¿-methyl ester

Jokiniemi J, Vuokila-Laine E, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2007. Crystengcomm. 9: 158-164

Synthesis of novel optical isomers of [alpha]-methylpolyamines

Grigorenko NA, Khomutov AR, Keinänen TA, Järvinen A, Alhonen L, Jänne J, Vepsäläinen J. 2007. Tetrahedron. 63: 2257-2262

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates

Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. British journal of pharmacology. 147: 437-445

A novel and selective synthesis of di- and trimethylpiperazinium acetic acid iodide salts

Holappa J, Nevalainen T, Safin R, Vepsäläinen J, Järvinen T. 2006. Tetrahedron letters. 47: 323-325

Activated polyamine catabolism in acute pancreatitis. Alpfa-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality

Hyvönen MT, Herzig K-H, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L. 2006. American journal of pathology. 168: 115-122

Alfa-methyl polyamines: efficient synthesis and tolerance studies in vivo and vitro. First evidence for dormant stereospecificity of polyamine oxidase

Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE. 2006. Journal of medicinal chemistry. 49: 399-406

Aminooxy analogues of spermine and their monoacetyl derivatives

Simonyan AR, Vepsalainen J, Khomutov AR. 2006. Russian journal of bioorganic chemistry. 32: 578-585

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

Jarho EM, Venäläinen J, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JAM, Forsberg MM, Järvinen T, Männistö PT, Wallén EAA. 2006. Bioorganic and medicinal chemistry letters. 16: 5590-5593

Controlling the regio- and stereospecifity of enzyme catalysis with guide molecules

Keinänen T, Järvinen A, Vepsäläinen J, Uimari A, Alhonen L, Jänne J. 2006.

Convenient microwave-assisted synthesis of 1-chloroethyl phosphates

Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J. 2006. CHEMINFORM. 37:

Efficient strategy to prepare water-soluble prodrugs of ketones

Huttunen KM, Kumpulainen H, Leppänen J, Rautio J, Järvinen T, Vepsäläinen J. 2006. Synlett. : 701-704

Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure

Kumpulainen H, Mähönen N, Laitinen M-L, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J. 2006. Journal of medicinal chemistry. 49: 1207-1211

Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase

Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J. 2006. Journal of biological chemistry. 281: 4589-4595

Novel one-pot synthesis of amide derivatives of methylenebisphosphonate utilizing the mesyl moiety as leaving group

Jokiniemi J, Ahlgrén M, Vepsäläinen JJ. 2006. Letters in organic chemistry. 3: 898-900

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. 2006. Journal of medicinal chemistry. 49: 2022-2027

Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists

Raitio KH, Savinainen JR, Nevalainen T, Järvinen T, Vepsäläinen J. 2006. Chemical biology and drug design. 68: 334-340

Synthesis of novel (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives

Turhanen P, Vepsalainen JJ. 2006. Beilstein journal of organic chemistry. 2:2:

The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms

Lewandowicz AM, Vepsäläinen J, Laitinen JT. 2006. British journal of pharmacology. 147: 422-429

A charge-deficient analogue of spermine with chelating properties

Khomutov AR, Grigorenko NA, Skuridin SG, Demin AV, Vepsalainen J, Casero RA, Woster PM. 2005. Russian journal of bioorganic chemistry. 31: 271-278

An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates

Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J. 2005. Journal of organic chemistry. 70: 9056-9058

Catena-Poly[diaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O,O':O''-tetraaquazinc(II)--(diethyl dichloromethylenebisphosphonato)-3O:O',O'']

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Acta crystallographica section C : crystal structure communications. : m635-m637

Catena-poly[diaquacadmium(II)-my-(diethyl dichloromethylenebisphosphonato)-kappa3 O,O':O'' -tetraaquacadmium(II)-my -(diethyl dichloromethylenebisphosphonato-)kappa3 O:O',O'']

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Acta crystallographica section C : crystal structure communications. : m638-m640

Catena-poly[diaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o,ó:o" -tetraaquazinc(II)-my-(diethyl dichloromethylenebisphosphonato)-k3 o:ó,o"]

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Acta crystallographica section E : structure reports online. E61: m635-m637

Isolation and characterization of yuremamine, a new phytoindole

Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. 2005. Planta medica. 71: 1053-1057

Metabolic stability of alfa-methylated polyamine derivatives and their use as substitutes for the natural polyamines

Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J. 2005. Journal of biological chemistry. 280: 6595-6601

New charge-deficient agmatine analogues

Simonyan AR, Grigorenko NA, Vepsalainen J, Khomutov AR. 2005. Russian journal of bioorganic chemistry. 31: 583-587

New oxaanalogues of spermine

Khomutov AR, Simonyan AR, Vepsalainen J, Keinanen TA, Alhonen L, Janne J. 2005. Russian journal of bioorganic chemistry. 31: 189-195

New syntheses of alfa-methyl- and alfa,alfa'-dimethylspermine

Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR. 2005. Russian journal of bioorganic chemistry. 31: 183-188

Polymethylene derivatives of nucleic bases with omega-functional groups: IV.1[7-(2-oxocyclohexyl)-7-oxoheptyl]purines

Kritzyn AM, Vepsalainen J, Komissarov VV. 2005. Russian journal of bioorganic chemistry. 31: 256-262

Simplified synthesis of N-(3-[18F]-fluoropropyl)-2beta-carbomethoxy-3beta-(4-fluorophenyl)-nortropane([18F]beta-CFT-FP using [18F]fluoropropyl tosylate as the labelling reagent

Koivula T, Perhola O, Kämäräinen E-L, Lipponen T, Vepsäläinen J, Solin O. 2005. Journal of labelled compounds and radiopharmaceuticals. 48: 463-471

Strategies for organic impurity quantification by 1H NMR spectroscopy: constrained total-line-shape fitting

Soininen P, Haarala J, Vepsäläinen J, Niemitz M, Laatikainen R. 2005. Analytica chimica acta. 542: 178-185

Structures of bisphosphonate metal complexes: zinc and cadmium complexes of clodronate and its partial ester derivatives

Kontturi M, Laurila E, Mattsson R, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Inorganic chemistry. 44: 2400-2406

Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters

Airaksinen AJ, Huotari M, Shvetsov A, Vainiotalo P, Männisto PT, Tuomisto L, Bergström K, Vepsäläinen J. 2005. European journal of medicinal chemistry. 40: 299-304

Synthesis of (R)- and (S)-isomers of 1-methylspermidine

Grigorenko NA, Vepsalainen JJ, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR. 2005. Mendeleev communications. 15: 142-143

Synthesis of 9-[2-O-(2-methoxyethyl)-beta-D-ribofuranosyl]purines using 1-methanesulfonyloxy-2-methoxyethane

Sivets GG, Vepsäläinen J, Mikhailopulo IA. 2005. Letters in organic chemistry. 2: 343-348

Synthesis of novel fatty acid derivatives of etidronic acid

Turhanen PA, Vepsäläinen JJ. 2005. Synthesis: stuttgart. : 3063-3066

The first synthesis of novel (1-alkoxycarbonyloxyethylidene)-1,1-bisphosphonic acid derivatives taking advantage of the rearrangement characteristic of the tetramethyl ester of etidronate

Turhanen PA, Vepsäläinen JJ. 2005. Synthesis: stuttgart. : 2119-2121

X-ray diffraction study of bisphosphonate metal complexes: Mg and Ca complexes of (dichloromethylene)bisphosphonic acid P,P'-diisopropyl ester

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2005. Polyhedron. 24: 305-309

3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L

Kalinichenko EN, Podkopaeva TL, Budko EV, Seela F, Dong B, Silverman R, Vepsäläinen J, Torrence PF, Mikhailopulo IA. 2004. Bioorganic and medicinal chemistry. 12: 3637-3647

A structural study of bisphosphonate metal complexes - three new polymeric structures of the calcium complex of clodronic acid

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. European journal of inorganic chemistry. : 2627-2631

Conformational and biochemical analysis of the cyclic peptides which modulate serine protease activity

Pakkala M, Jylhäsalmi A, Wu P, Leinonen J, Stenman U-H, Santa H, Vepsäläinen J, Peräkylä M, Närvänen A. 2004. Journal of peptide science. 10: 439-447

Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone

Mäntylä A, Rautio J, Nevalainen T, Keski-Rahkonen P, Vepsäläinen J, Järvinen T. 2004. European journal of pharmaceutical sciences. : 151-158

Effects of triaryl phosphates on mouse and human nuclear receptors

Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. 2004. Biochemical pharmacology. 67: 97-106

Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration

Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J. 2004.

Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration (in Japanese)

Rasanen T-L, Alhonen L, Sinervirta R, Keinanen T, Herzig K-H, Khomutov AR, Vepsalainen J, Janne J. 2004.

One-pot synthesis of 1-[(1-phenyl-1-dialkoxyphosphoryl)-methyl]-2-pyrrolidinone

Turhanen PA, Soininen P, Vepsäläinen JJ. 2004. Letters in organic chemistry. : 343-345

Pentaaqua (dichloromethylenebisphosphonato)strontium(II)

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. Acta crystallographica section C : crystal structure communications. E60: m1060-m1062

Poly[[tetraaqua(my7-hydrogen dichloromethylenebisphosphonato)(my5-hydrogen dichloromethylenebisphosphonato)tribarium(II)] monohydrate)

Kontturi M, Peräniemi S, Vepsäläinen JJ, Ahlgrén M. 2004. Acta crystallographica section C : crystal structure communications. : m592-m594

Strategies for the preparation of (1-acetyloxyethylidene)-1,1-bisphosphonic acid derivatives

Turhanen PA, Vepsäläinen JJ. 2004. Synthesis: stuttgart. : 0992-0994

Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives

Mäntylä A, Rautio J, Nevalainen T, Vepsälainen J, Juvonen R, Kendrick H, Garnier T, Croft SL, Järvinen T. 2004. Bioorganic and medicinal chemistry. 12: 3497-3502

Synthesis of some mono-mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity

Gul HI, Calis U, Vepsäläinen J. 2004. Arzneimittel-forschung-drug research. 54: 359-364

Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone

Mäntylä A, Garnier T, Rautio J, Nevalainen T, Vepsäläinen J, Koskinen A, Croft SL, Järvinen T. 2004. Journal of medicinal chemistry. 47: 188-195

Time-resolved growth behavior of acid aerosols in ethanol vapor with a tandem-DMA technique

Joutsensaari J, Toivonen T, Vaattovaara P, Vesterinen M, Vepsäläinen J, Laaksonen A. 2004. Journal of aerosol science. : 851-867

Addition of tert-butylcuprate to (2S)-N-acyl-delta5-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2S,5S)-5-tert-butylproline

Wallén EAA, Christiaans JAM, Gynther J, Vepsäläinen J. 2003. Tetrahedron letters. 44: 2081-2082

Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects

Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. European journal of pharmaceutical sciences. 19: 23-29

Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells

Gul HI, Gul M, Vepsälainen J, Erciyas E, Hänninen O. 2003. Biological and pharmaceutical bulletin. 26: 631-637

Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen aihiolääkkeitä sisältävät farmaseuttiset koostumukset topikaaliseen käyttöön

Järvinen T, Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J. 2003.

First synthesis of etidronate partial amides starting from PCI3

Turhanen PA, Niemi R, Peräkylä M, Järvinen T, Vepsäläinen JJ. 2003. Organic and biomolecular chemistry. 1: 3223-3226

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro*

Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OHJ, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. 2003. Journal of biological chemistry. 278: 45915-45923

Reduction of 6/7-substituted 3-phenyltrop-3-en-2-ones: stereoselectivity and conformational analysis of the products

Airaksinen AJ, Lipsonen J, Ahlgren M, Vainiotalo P, Bergström KA, Laatikainen R, Vepsäläinen J. 2003. Tetrahedron. 59: 377-383

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether

Juntunen J, Vepsäläinen J, Niemi R, Laine K, Järvinen T. 2003. Journal of medicinal chemistry. 46: 5083-5086

A novel synthetic route for the preparation of alkyl and benzyl chloromethyl phosphates

Mäntylä A, Vepsäläinen J, Järvinen T, Nevalainen T. 2002. Tetrahedron letters. 43: 3793-3794

A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism

Räsänen T-L, Alhonen L, Sinervirta R, Keinänen T, Herzig K-H, Suppola S, Khomutov AR, Vepsäläinen J, Jänne J. 2002. Journal of biological chemistry. 277: 39867-39872

A structural study of bisphosphonate metal complexes. Alkaline earth metal complexes of (dichloromethylene)bisphosphonic acid P,P' -diethyl ester

Kontturi M, Vuokila-Laine E, Peräniemi S, Pakkanen TT, Vepsäläinen JJ, Ahlgrén M. 2002. JOURNAL OF THE CHEMICAL SOCIETY. DALTON TRANSACTIONS. : 1969-1973

Bisphosphonate prodrugs

Vepsäläinen JJ. 2002. Current medicinal chemistry. 9: 1075-1085

One-pot synthesis of 3,4-disubstituted 1H-pyrroles from 2-tropanones

Airaksinen AJ, Ahlgren M, Vepsäläinen J. 2002. Journal of organic chemistry. 67: 5019-5021

Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2a-(imino-methyl)-3b-(3',4'-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

Yu M, Airaksinen AJ, Gee AD, Lötjönen S, Kuikka JT, Vepsäläinen JJ, Hiltunen J, Bergström KA. 2002. Journal of labelled compounds and radiopharmaceuticals. 45: 1011-1017

Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols

Gul HI, Calis U, Vepsalainen J. 2002. Arzneimittel-forschung-drug research. 52: 863-869

Synthesis of anhydro psicofuranosyl nucleosides

Roivainen J, Vepsäläinen J, Azhayev A, Mikhailopulo IA. 2002. Tetrahedron letters. 43: 6553-6555

Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone

Gul HI, Ojanen T, Vepsalainen J, Gul M, Erciyas E, Hanninen O. 2001. Arzneimittel-forschung-drug research. I: 72-75

Bisphosphonate prodrugs. Synthesis and identification of (1-hydroxyethylidene)-1,1-bisphosphonic acid tetraesters by mass spectrometry, NMR spectroscopy and X-ray crystallography

Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen JJ. 2001. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS. 170: 115-133

Bisphosphonate prodrugs: selective synthesis of (1-hydroxyethylidene)-1,1-bisphosphonate partial esters

Turhanen PA, Ahlgren MJ, Järvinen T, Vepsäläinen J. 2001. Synthesis: stuttgart. : 633-637

Effect of acetophenone derived Mannich bases on cellular glutathione level in Jurkat cells

Gul M, Gul HI, Vepsalainen J, Erciyas E, Hanninen O. 2001. Arzneimittel-forschung-drug research. 51: 679-682

Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells

Raiman J, Niemi R, Vepsäläinen J, Yritys K, Järvinen T, Mönkkönen J. 2001. International journal of pharmaceutics. 213: 135-142

Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography

Tupala E, Kuikka JT, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, Hiltunen J, Vepsäläinen J, Tiihonen J. 2001. Neuroimage. 14: 87-94

Novel acid-free cleavage of N-(2-hydroxyarylidene) protected amines

Khomutov AR, Shvetsov AS, Vepsäläinen JJ, Kritzyn AM. 2001. Tetrahedron letters. 42: 2887-2889

A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations

Kovalainen JT, Christiaans JAM, Ropponen R, Poso A, Peräkylä M, Vepsäläinen J, Laatikainen R, Gynther J. 2000. Journal of the American Chemical Society. 122: 6989-6996

Bisphosphonate prodrugs: synthesis and vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate

Niemi R, Turhanen P, Vepsäläinen J, Taipale H, Järvinen T. 2000. European journal of pharmaceutical sciences. 11: 173-180

Conformational flexibility and role of aromatic-aromatic interactions in the crystal packing of the coordination compounds of some novel quadridentate Schiff bases

Pulkkinen JT, Laatikainen R, Ahlgrén MJ, Peräkylä M, Vepsäläinen JJ. 2000. JOURNAL OF THE CHEMICAL SOCIETY. PERKIN 2. 2: 777-784

Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells

Gul HI, Vepsalainen J, Gul M, Erciyas E, Hanninen O. 2000. PHARMACEUTICA ACTA HELVETIAE. 74: 393-398

Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties

Tennilä T, Azhayeva E, Vepsäläinen J, Laatikainen R, Azhayev A, Mikhailopulo IA. 2000. Nucleosides nucleotides and nucleic acids. 19: 1861-1884

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. European journal of pharmaceutical sciences. 11: 157-163

Preparation of (18F)beta-CFT-FP and (11C)beta-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)

Kämäräinen E-L, Kyllönen T, Airaksinen A, Lundkvist C, Yu M, Någren K, Sandell J, Langer O, Vepsäläinen J, Hiltunen J, Bergström K, Lötjönen S, Jaakkola T, Halldin C. 2000. Journal of labelled compounds and radiopharmaceuticals. 43: 1235-1244

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T. 2000. Journal of medicinal chemistry. 43: 1489-1494

Synthesis of a water-soluble prodrug of entacapone

Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T. 2000. Bioorganic and medicinal chemistry letters. 10: 1967-1969

Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters

Ahlmark MJ, Vepsäläinen JJ. 2000. Tetrahedron. 56: 5213-5219

Uudet metyleenibisfosfonihappojohdannaiset

Pohjola EK, Vepsäläinen J, Nupponen H, Kähkönen JP, Lauren L, Hannuniemi R, Järvinen TL, Ahlmark MJ. 2000.

1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists

Kovalainen JT, Christiaans JAM, Poso A, Vepsäläinen J, Laatikainen R, Gynther J. 1999. Tetrahedron letters. 40: 2425-2428

3rd Spring Meeting on the Division of Synthetic Chemistry Kuopio June 1-2, 1999. Abstracts. 21st Finnish NMR Symposium. Kuopio June 2-4, 1999. Abstracts

Vepsäläinen J. 1999. Kuopion yliopiston julkaisuja C. Luonnontieteet ja ympäristötieteet. . -

Bisphosphonate prodrugs: a new synthetic strategy to tetraacyloxymethyl esters of methylenebisphosphonates

Vepsäläinen JJ. 1999. Tetrahedron letters. 40: 8491-8493

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid

Niemi R, Vepsäläinen J, Taipale H, Järvinen T. 1999. Journal of medicinal chemistry. 42: 5053-5058

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate

Ahlmark M, Vepsäläinen J, Taipale H, Niemi R, Järvinen T. 1999. Journal of medicinal chemistry. 42: 1473-1476

Characterization of a conformationally flexible system: NMR spectroscopic study of 1,5-diphenylpentane-2,4-dione

Pulkkinen JT, Laatikainen R, Vepsäläinen JJ, Ahlgrén MJ. 1999. Magnetic resonance in chemistry. 37: 119-126

Novel methylenebisphosphonic acid derivatives

Pohjola E, Vepsäläinen J, Nupponen H, Kähkönen J, Laurén L, Hannuniemi R, Järvinen T, Ahlmark M. 1999.

Nuclear magnetic resonance and molecular orbital study of some cocaine analogues

Airaksinen AJ, Tuppurainen KA, Lötjönen SE, Niemitz M, Yu M, Vepsäläinen JJ, Laatikainen R, Hiltunen J, Bergström KA. 1999. Tetrahedron. 55: 10537-10546

Radiolääkekehitys avaa uusia ikkunoita aivoihin

Bergström K, Airaksinen A, Lötjönen S, Kuikka J, Vepsäläinen J. 1999. KEMIA-KEMI. 26: 391-394

Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid as novel naproxen prodrugs for dermal drug delivery

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T. 1999. Pharmaceutical research. 16: 1172-1178

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel partial amides of clodronic acid

Niemi R, Pennanen H, Vepsäläinen J, Taipale H, Järvinen T. 1998. International journal of pharmaceutics. 174: 111-115

In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen

Rautio J, Taipale H, Gynther J, Vepsäläinen J, Nevalainen T, Järvinen T. 1998. Journal of pharmaceutical sciences. 87: 1622-1628

Complete spectral analysis of the 1H NMR 16-spin system of beta-pinene

Kolehmainen E, Laihia K, Laatikainen R, Vepsäläinen J, Niemitz M, Suontamo R. 1997. Magnetic resonance in chemistry. 35: 463-467

Identification of a common structural motif in the disordered N-terminal region of bacterial flagellins Evidence for a new class of fibril-forming peptides

Hakalehto E, Santa H, Vepsäläinen J, Laatikainen R, Finne J. 1997. Febs journal. 250: 19-29

Preparation and identification of tetraamide esters of methylene- and (dichloromethylene)bisphosphonates

Vepsäläinen J, Vainiotalo P, Nupponen H, Pohjola E. 1997. ACTA CHEMICA SCANDINAVICA. 51: 932-937

Simultaneous determination of clodronate and its partial ester derivatives by ion-pair reversed-phase high-performance liquid chromatography coupled with evaporative light-scattering detection

Niemi R, Taipale H, Ahlmark M, Vepsäläinen J, Järvinen T. 1997. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 701: 97-102

Strategies for the selective synthesis of monosubstituted (dichloromethylene)bisphosphonate esters

Ahlmark MJ, Vepsäläinen JJ. 1997. Tetrahedron. 53: 16153-16160

3-unsubstituted 1,5-Diaryl-2,4-pentanediones and -4-methoxy-2- pentanones: Synthesis via corresponding 3-hydroxy ketones generated from 2-isoxazolines

Pulkkinen JT, Vepsäläinen JJ. 1996. Journal of organic chemistry. 61: 8604-8609

Bisphosphonic compounds VIII. A facile and selective one-pot synthesis of P,P-dialkyl (dichloromethylene)bisphosphonate partial esters

Vepsäläinen J, Nupponen H, Pohjola E. 1996. Tetrahedron letters. 37: 3533-3536

General strategies for total-lineshape-type spectral analysis of NMR spectra using integral-transform iterator

Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T, Vepsäläinen J. 1996. JOURNAL OF MAGNETIC RESONANCE (A). 120: 1-10

New aminooxy analogs of biogenic polyamines (in Russian)

Khomutov AR, Shvetsov AS, Vepsalainen J, Kramer DL, Hyvonen T, Keinanen T, Eloranta TO, Porter CW, Khomutov RM. 1996. Bioorganicheskaya khimiya. 22: 557-559

Performic acid oxidation of exo-2-syn-7-bicyclo[2.2.1]hept-5-enediol. 1H and 13C NMR spectroscopic structure elucidation of the reaction products

Laihia K, Kolehmainen E, Mänttäri P, Ryynänen R, Messala-Rannanpiha M, Vepsäläinen J, Sundelin J-P. 1996. Spectrochimica acta part a: molecular and biomolecular spectroscopy. 51: 495-504

Preparation and structure determination of 1-benzyl-, 1-methyl- and 1H-5-[(nitro-2-phenyl)ethenyl]imidazoles

Aulaskari P, Ahlgrén M, Rouvinen J, Vainiotalo P, Pohjala E, Vepsäläinen J. 1996. Journal of heterocyclic chemistry. 33: 1345-1354

Synthesis of hydroxylamine analogues of polyamines

Khomutov AR, Vepsäläinen JJ, Shvetsov AS, Hyvönen T, Keinänen TA, Pustobaev VN, Eloranta TO, Khomutov RM. 1996. Tetrahedron. 52: 13751-13766

An improved synthetic method and the first crystal structures for (dihalomethylene)bisphosphonate partial esters

Vepsäläinen JJ, Kivikoski J, Ahlgrén M, Nupponen HE, Pohjola EK. 1995. Tetrahedron. 51: 6805-6818

Comparison of enzymatic hydrolysis of pilocarpine prodrugs in human plasma, rabbit cornea, and butyrylcholinesterase solutions

Järvinen T, Poikolainen M, Suhonen P, Vepsäläinen J, Alaranta S, Urtti A. 1995. Journal of pharmaceutical sciences. 84: 656-660

Conformationally biased tri- and di-basic 1,3,5-triazacyclohexyl ligands

Angelis de S, Batsanov A, Norman TJ, Parker D, Senanayake K, Vepsalainen J. 1995. Chemical communications. : 2361-2363

Synthesis of a tritium labelled antihistaminic drug [3H]-N,N-diethyl-2-[4-(phenylmethylphenoxy]-ethaneamine * HCl

Kovalainen JT, Morimoto H, Williams PG, Vepsäläinen J, Reijonen A, Gynther J. 1995. Journal of labelled compounds and radiopharmaceuticals. 36: 1147-1156

A general route to 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones

Pulkkinen, Juha; Vepsäläinen, Jouko; Laatikainen, Reino. 1994. Tetrahedron letters. 35: 9749-9750

Research groups

Projects

Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia

Valorization potential of the aqueous products from hydrothermal liquefaction and stepwise slow pyrolysis of wood bark and hemp hurds with yields and product comparison

Effects of tree harvesting time and tannin cold/hot-water extraction procedures on the performance of spruce tannin biocoagulant for water treatment

Functionalized nanoporous silicon for extraction of Sc from a leach solution

Real-Time On-Site Multielement Analysis of Environmental Waters with a Portable X-ray Fluorescence (pXRF) System

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots

Bioethanol production from short rotation S. schwerinii E. Wolf is carbon neutral with utilization of waste-based organic fertilizer and process carbon dioxide capture

Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria

Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel

Effect of solvent mixture pretreatment on sugar release from short-rotation coppice Salix schwerinii for biobutanol production

Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus

Extractives of Stemwood and Sawmill Residues of Scots Pine (Pinus sylvestris L.) for Biorefining in Four Climatic Regions in Finland - Phenolic and Resin Acid Compounds

Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption

Recovery of uranium with bisphosphonate modified mesoporous silicon

Slow pyrolysis liquid in reducing NH3 emissions from cattle slurry - Impacts on plant growth and soil organisms

Acetone-butanol-ethanol Fermentation from Different Pulp and Paper Manufacturing Process Side-streams

Complementary chemical characterization of distillates obtained from industrial hemp hurds by thermal processing

Cost-effective FTIR and 1H NMR spectrometry used to screen valuable molecules extracted from selected West African trees by a sustainable biochar process

Effective separation of uranium from mine process effluents using chitosan as a recyclable natural adsorbent

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Potential of pyrolysis liquids to control the environmental weed Heracleum mantegazzianum

Rapid synthesis of nanostructured porous silicon carbide from biogenic silica

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

Bisphosphonate modified mesoporous silicon for scandium adsorption

Chelate-assisted phytoextraction: Growth and ecophysiological responses by Salix schwerinii E.L Wolf grown in artificially polluted soils

Effect of salts formed by neutralization for the enzymatic hydrolysis of cellulose and acetone-butanol-ethanol fermentation

Green and Efficient Esterification Method Using Dried Dowex H+/NaI Approach

Kohti kokonaisvaltaisempia kaivosvesiratkaisuja: KaivosVV-hankkeen loppuraportti

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives

Acetone-Butanol-Ethanol Fermentation of Non-detoxified Dilute Acid extracted Hemicellulosic Hydrolysate from the Short-rotation Coppice Salix schwerinii E. Wolf

Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase

Altered polyamine profiles in colorectal cancer

Association between periprosthetic tissue metal content, whole blood and synovial fluid metal ion levels and histopathological findings in patients with failed metal-on-metal hip replacement

Controlling of N-Alkylpolyamine Analogue Metabolism by Selective Deuteration

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Influence of size reduction treatments on sugar recovery from Norway spruce for butanol production

Enhanced acetone-butanol-ethanol production from lignocellulosic hydrolysates by using starchy slurry as supplement

On the reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines : unexpected degradation of P-C-P Bridge

Urinary Polyamines as Biomarkers for Ovarian Cancer

Convenient Syntheses of Phosphinic Analogues of gamma-Aminobutyric- and Glutamic Acids

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity

Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase

Preparation of useful building blocks, a-iodo- and bromoalkanols from cyclic ethers using the Dowex H+/NaX (X = I, Br) approach

Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

Triethylenetetramine Modulates Polyamine and Energy Metabolism and Inhibits Cancer Cell Proliferation

A powerful tool for acid catalyzed organic addition and substitution reactions

Advanced material and approach for metal ions removal from aqueous solutions

Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

Enantioselective synthesis of (R)- and (S)-3-methylspermidines

Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation

In Silico Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids

Selective acetylation of primary amino groups with phenyl acetate: simple conversion of polyamines into N,N'-diacetyl derivatives

Structural Requirements for Bisphosphonate Binding on Hydroxyapatite: NMR Study of Bisphosphonate Partial Esters

Synthesis of biologically active analogues of spermine and spermidine

Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Urinary acetylated polyamines in ovarian cancer

Uusi menetelmä ja uusi katalyyttinen järjestelmä selektiivisiin orgaanisiin additio- ja substituutioreaktioihin

Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence

Assessing the response of plant flavonoids to UV radiation: an overview of appropriate techniques

Bisphosphonates: How does the structure affect the ability to bind to hydroxyapatite?

Co-fermentation of hemicellulose and starch from barley straw and grain for efficient pentoses utilization in acetone-butanol-ethanol production

Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study

Eletroninen nenä havaitsee eturauhassyövän virtsasta [Detection of prostate cancer by an eletronic nose: a proof-of-principle study. J Urol, julkaistu verkossa 25.2.2014]

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism

Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol

Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS

Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS

Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme

The use of (green field) biomass pretreatment liquor for fermentative butanol production and the catalytic oxidation of biobutanol

Uraanin ja muiden raskasmetallien poistaminen vedestä

A bisphosphonate increasing the shoot biomass of the metal hyperaccumulator Noccaea caerulescens