Marja Hedman

4D Flow Versus 2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves

Hautanen, S; Kiljander, T; Korpela, T; Saari, P; Kokkonen, J; Mustonen, P; Sillanmäki, S; Ylä-Herttuala, E; Husso, M; Hedman, M; Kauhanen, P. 2023. In vivo. 37: 88-98 A1 Journal article (refereed), original research

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

Valtola, Kati; Hedman, Marja; Kantola, Ilkka; Walls, Susanne; Helisalmi, Seppo; Maria, Maleeha; Raivo, Joose; Auray-Blais, Christiane; Kuusisto, Johanna. 2023. Open heart. 10: A1 Journal article (refereed), original research

Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy

Sarin, Jaakko K; Kiema, Miika; Luoto, Emma-Sofia; Husso, Annastiina; Hedman, Marja; Laakkonen, Johanna P; Torniainen, Jari. 2023. Journal of surgical research. 287: 82-89 A1 Journal article (refereed), original research

Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease

Hämäläinen, Hanna; Laitinen, Tiina M; Hedman, Marja; Hedman, Antti; Kivelä, Antti; Laitinen, Tomi P. 2022. Clinical physiology and functional imaging. 42: 413-421 A1 Journal article (refereed), original research

Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up

Kauhanen, Petteri; Korpela, Tarmo; Hedman, Marja. 2022. European journal of radiology. 150: A1 Journal article (refereed), original research

Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms

Jauhiainen, Suvi; Kiema, Miika; Hedman, Marja; Laakkonen, Johanna P. 2022. Arteriosclerosis, thrombosis, and vascular biology. 42: 811-818 A2 Review article, Literature review, Systematic review

Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report

Sillanmäki, Saara; Istomina, Maria; Husso, Annastiina; Hedman, Marja. 2022. European heart journal: Case reports. 6: A1 Journal article (refereed), original research

Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study

Prescott, Eva; Angerås, Oskar; Erlinge, David; Grove, Erik L; Hedman, Marja; Jensen, Lisette O; Pernow, John; Saraste, Antti; Åkerblom, Axel; Svedlund, Sara; Rudvik, Anna; Knöchel, Jane; Lindstedt, Eva-Lotte; Garkaviy, Pavlo; Gan, Li-Ming; Gabrielsen, Anders. 2022. International journal of cardiology. 365: 34-40 A1 Journal article (refereed), original research

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta

Kiema, Miika; Sarin, Jaakko K; Kauhanen, S Petteri; Torniainen, Jari; Matikka, Hanna; Luoto, Emma-Sofia; Jaakkola, Pekka; Saari, Petri; Liimatainen, Timo; Vanninen, Ritva; Ylä-Herttuala, Seppo; Hedman, Marja; Laakkonen, Johanna P. 2022. Frontiers in physiology. 13: A1 Journal article (refereed), original research

Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals

Klumpp, Matthias; Hintze, Marcus; Immonen, Milla; Ródenas-Rigla, Francisco; Pilati, Francesco; Aparicio-Martínez, Fernando; Çelebi, Dilay; Liebig, Thomas; Jirstrand, Mats; Urbann, Oliver; Hedman, Marja; Lipponen, Jukka A.; Bicciato, Silvio; Radan, Anda-Petronela; Valdivieso, Bernardo; Thronicke, Wolfgang; Gunopulos, Dimitrios; Delgado-Gonzalo, Ricard. 2021. Healthcare. 9: 961 A1 Journal article (refereed), original research

Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position

Kauhanen, S Petteri; Saari, Petri; Korpela, Tarmo; Liimatainen, Timo; Vanninen, Ritva; Hedman, Marja. 2021. Acta radiologica. [First Published July 25, 2021]: 1-9 A1 Journal article (refereed), original research

Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation

Korpela, Tarmo; Kauhanen, S Petteri; Kariniemi, Elina; Saari, Petri; Liimatainen, Timo; Jaakkola, Pekka; Vanninen, Ritva; Hedman, Marja. 2021. European journal of cardio-thoracic surgery. 2022; 61: 395-402 A1 Journal article (refereed), original research

Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population

Kauhanen, S. Petteri; Liimatainen, Timo; Korhonen, Miika; Parkkonen, Johannes; Vienonen, Juska; Vanninen, Ritva; Hedman, Marja. 2021. In vivo. 35: 2177-2185 A1 Journal article (refereed), original research

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death

Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. Biomolecules. 11: 452 A1 Journal article (refereed), original research

Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease

Hämäläinen, H; Corovai, A; Laitinen, J; Laitinen, TM; Hedman, M; Hedman, A; Kivelä, A; Laitinen, TP. 2020. Journal of nuclear cardiology. 2021; 28: 3010-3020 A1 Journal article (refereed), original research

Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events

Onatsu, Juha; Vanninen, Ritva; Jäkälä, Pekka; Mustonen, Pirjo; Pulkki, Kari; Korhonen, Miika; Hedman, Marja; Höglund, Kina; Blennow, Kaj; Zetterberg, Henrik; Herukka, Sanna-Kaisa; Taina, Mikko. 2020. In vivo. 34: 2577-2586 A1 Journal article (refereed), original research

Effect of middle cerebral artery territory ischemic stroke on QT interval

Simula Sakari, Muuronen Antti T, Taina Mikko, Jäkälä Pekka, Sipola Petri, Vanninen Ritva, Hedman Marja. 2013. Journal of stroke and cerebrovascular diseases. [Epub ahead of print]: 1-7 A1 Journal article (refereed), original research

Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

Hedman M, Muona K, Hedman A, Kivelä A, Syvänne M, Eränen J, Rantala A, Stjernvall J, Nieminen MS, Hartikainen J, Ylä-Herttuala S. 2009. Gene therapy. 16: 629-634 A1 Journal article (refereed), original research

New technologies in cardiovascular research gene therapy

Hedman M, Turunen MP, Ylä-Herttuala S. Teoksessa: Pasterkamp G, de Kleijn DPV, 2006. Cardiovascular Research. New Technologies, Methods, and Applications. s. 85-101. A3 Book section, Chapters in research books

Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy

Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M, Ylä-Herttuala S. 2006. Current drug safety. 1: 253-257 A1 Journal article (refereed), original research

Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries

Bhardwaj S, Roy H, Kärpänen T, Hi Y, Jauhiainen S, Hedman M, Alitalo K, Ylä-Herttuala S. 2005. Gene therapy. 12: 388-394 A1 Journal article (refereed), original research

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart

Rutanen J, Rissanen TT, Markkanen JE, Gruchala M, Silvennoinen P, Kivelä A, Hedman A, Hedman M, Heikura T, Ordén M-R, Stacker SA, Achen MG, Hartikainen J, Ylä-Herttuala S.. 2004. Circulation. 109: 1029-1035 A1 Journal article (refereed), original research

Angiogenic responses of vascular endothelial growth factors in periadventitial tissue

Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, Kokina I, Achen MG, Stacker SA, Hedman M, Alitalo K, Ylä-Herttuala S. 2003. Human gene therapy. 14: 1451-1462 A1 Journal article (refereed), original research

Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]

Hedman M, Hartikainen J, Syvänne M, Stjernvall J, Hedman A, Kivelä A, Vanninen E, Mussalo H, Kauppila E, Simula S, Närvänen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Ylä-Herttuala S. 2003. Circulation. 107: 2677-2683 A1 Journal article (refereed), original research

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

Hiltunen MO, Turunen MP, Häkkinen TP, Rutanen J, Hedman M, Mäkinen K, Turunen A-M, Aalto-Setälä K, Ylä-Herttuala S. 2002. Vascular medicine. 7: 5-11 A1 Journal article (refereed), original research

Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study

Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E, Ylä-Herttuala S. 2002. Molecular therapy. 6: 127-133 A1 Journal article (refereed), original research

Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods

Hiltunen MO, Turunen MP, Turunen A-M, Rissanen TT, Laitinen M, Kosma V-M, Ylä-Herttuala S. 2000. Faseb journal. 14: 2230-2236 A1 Journal article (refereed), original research

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

Laitinen M, Hartikainen J, Hiltunen MO, Eränen J, Kiviniemi M, Närvänen O, Mäkinen K, Manninen H, Syvänne M, Martin JF, Laakso M, Ylä-Herttuala S. 2000. Human gene therapy. 11: 263-270 A1 Journal article (refereed), original research

Gene therapy for the treatment of peripheral vascular disease and coronary artery disease

Hedman M, Ylä-Herttuala S. 2000. Drugs of today. 36: 609-617 A1 Journal article (refereed), original research

Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer

Hiltunen MO, Turunen MP, Laitinen M, Ylä-Herttuala S. 2000. Vascular medicine. 5: 41-48 A1 Journal article (refereed), original research

Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta

Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A-M, Alitalo K, Ylä-Herttuala S. 2000. Circulation. 102: 2262-2268 A1 Journal article (refereed), original research

Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Alhava E, Ylä-Herttuala S. 2000. Journal of gene medicine. 2: 52-60 A1 Journal article (refereed), original research

Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res

Pakkanen TM, Laitinen M, Hippeläinen M, Kallionpää H, Lehtolainen P, Leppänen P, Luoma JS, Tarvainen R, Alhava E, Ylä-Herttuala S. 1999. Gene therapy. 6: 34-41 A1 Journal article (refereed), original research

Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies

Laitinen M. 1999. Kuopio University Publications D. Medical Sciences G5 Doctoral dissertation (article)

Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment

Pakkanen TM, Laitinen M, Hippeläinen M, Hiltunen MO, Lehtolainen P, Leppänen P, Luoma JS, Alhava E, Ylä-Herttuala S. 1999. Pharmacological research. 40: 451-457 A1 Journal article (refereed), original research

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, Agrawal RS, Pakkanen T, Luoma JS, Viita H, Hartikainen J, Alhava E, Laakso M, Ylä-Herttuala S. 1998. Human gene therapy. 9: 1481-1486 A1 Journal article (refereed), original research

Adventitial gene transfer to arterial wall

Laitinen M, Ylä-Herttuala S. 1998. Pharmacological research. 37: 251-254 A1 Journal article (refereed), original research

Adventitial gene transfer to rabbit carotid arteries

Laitinen M, Ylä-Herttuala S. Teoksessa: Jacotot B, Mathé D, Fruchart J-C, 1998. Atherosclerosis XI. XIth International Symposium on Atherosclerosis. -1: 689-691. Elsevier A4 Conference proceedings

Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings

Manninen HI, Vanninen RL, Laitinen M, Räsänen H, Vainio P, Luoma JS, Pakkanen T, Tulla H, Ylä-Herttuala S. 1998. Investigative radiology. 33: 464-471 A1 Journal article (refereed), original research

Vascular gene transfer for the treatment of restenosis and atherosclerosis

Laitinen M, Ylä-Herttuala S. 1998. Current opinion in lipidology. 9: 465-469 A1 Journal article (refereed), original research

Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses

Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agraval R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Ylä-Herttuala S. 1997. Human gene therapy. 8: 1645-1650 A1 Journal article (refereed), original research

Genteknologins möjligheter vid hjärt- och kärlsjukdomar

Laitinen M, Ylä-Herttuala S. 1997. Finsk tidskrift. : 527-536 D1 Article in a trade journal

VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries

Laitinen M, Zachary I, Breier G, Pakkanen T, Häkkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Ylä-Herttuala S. 1997. Human gene therapy. 8: 1737-1744 A1 Journal article (refereed), original research

Research groups

Keywords

4D Flow Versus 2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves

Late-onset and classic phenotypes of Fabry disease in males with the GLA-Thr410Ala mutation

Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy

Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease

Dilatation of the ascending aorta – Growth rate, risk factors and clinical outcomes in the long-term follow-up

Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms

Reversible myocardial ischaemia caused by ectopic left circumflex coronary artery: a case report

Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta

Artificial Intelligence for Hospital Health Care: Application Cases and Answers to Challenges in European Hospitals

Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position

Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation

Pulmonary Artery Dilatation Is a Common Finding in a Coronary Artery CT Angiography Population

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death

Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease

Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events

Effect of middle cerebral artery territory ischemic stroke on QT interval

Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

New technologies in cardiovascular research gene therapy

Safety profile of plasmid/liposomes and virus vectors on clinical gene therapy

Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries

Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart

Angiogenic responses of vascular endothelial growth factors in periadventitial tissue

Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II [...]

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study

Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

Gene therapy for the treatment of peripheral vascular disease and coronary artery disease

Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer

Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta

Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res

Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies

Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

Adventitial gene transfer to arterial wall

Adventitial gene transfer to rabbit carotid arteries

Intravascular ultrasound and magnetic resonance imaging in the assessment of atherosclerotic lesions in rabbit aorta. Correlation to histopathologic findings

Vascular gene transfer for the treatment of restenosis and atherosclerosis

Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses

Genteknologins möjligheter vid hjärt- och kärlsjukdomar

VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries