PETRI MäKINEN

Contact info

RESEARCH GROUPS - UEF

• 
  Molecular Medicine

PROJECTS - UEF

• 
  Biosafety level 3 (BSL-3) operating environment to secure vaccine production, investment plan
• 
  Biosafety level 3 (BSL-3) operating environment to secure vaccine production, development plan

Publications

• Ruotsalainen, Anna-Kaisa; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2021. Novel RNAi-Based Therapies for Atherosclerosis Current atherosclerosis reports 23 8: 45. 2021
• Lähteenvuo, Johanna; Hätinen, Olli-Pekka; Kuivanen, Antti; Huusko, Jenni; Paananen, Jussi; Lähteenvuo, Markku; Nurro, Jussi; Hedman, Marja; Hartikainen, Juha; Laham-Karam, Nihay; Mäkinen, Petri; Räsänen, Markus; Alitalo, Kari; Rosenzweig, Anthony; Ylä-Herttuala, Seppo. 2020. Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium Molecular therapy 28 7: 1-10. 2020
• Mehtonen, Juha; Teppo, Susanna; Lahnalampi, Mari; Kokko, Aleksi; Kaukonen, Riina; Oksa, Laura; Bouvy-Liivrand, Maria; Malyukova, Alena; Mäkinen, Artturi; Laukkanen, Saara; Mäkinen, Petri I; Rounioja, Samuli; Ruusuvuori, Pekka; Sangfelt, Olle; Lund, Riikka; Lönnberg, Tapio; Lohi, Olli; Heinäniemi, Merja. 2020. Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities Genome medicine 12 1: Article number: 99. 2020
• Mäkinen, P; Ruotsalainen, AK; Ylä-Herttuala, S. 2020. Nucleic Acid-Based Therapies for Atherosclerosis Current atherosclerosis reports 22 2: 10. 2020
• Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells Cellular and molecular life sciences [Published: 09 December 2019]: 1-23. 2019
• Banerjee, Shubhadeep; Sengupta, Jayeeta; Aljarilla, Ana; Setaro, Francesca; Mäkinen, Petri I; Wu, LinPing; Holappa, Lari; de la Escosura, Andres; Martinelli, Chiara; Trohopoulos, Panagiotis N; Ylä-Herttuala, Seppo; Urbanics, Rudolf; Szebeni, Janos; Torres, Tomas; Krol, Silke. 2019. Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques Precision Nanomedicine 2 2: 278-302. 2019
• Setaro, Francesca; Wennink, Jos W H; Mäkinen, Petri I; Holappa, Lari; Trohopoulus, Panagiotis N; Ylä-Herttuala, Seppo; van Nostrum, Cornelus F; De la Escosura, Andres; Torres, Tomás. 2019. Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers Journal of materials chemistry. b 2020; 8 2: 282-289. 2019
• Belt, H; Koponen, JK; Kekarainen, T; Puttonen, KA; Mäkinen, PI; Niskanen, H;, Oja, J; Wirth, G; Koistinaho, J; Kaikkonen, MU; Ylä-Herttuala, S. 2018. Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules. Frontiers in cardiovascular medicine 5: 16. 2018
• Merentie, Mari; Rissanen, Riina; Lottonen-Raikaslehto, Line; Huusko, Jenni; Gurzeler, Erika; Turunen, Mikko P; Holappa, Lari; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2018. Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice. PLOS ONE 13 1: e0190981. 2018
• Durga Devi T, Babu M, Mäkinen P, Kaikkonen M, Heinaniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N,Tavi P, Ylä-Herttuala S. 2017. Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation. AMERICAN JOURNAL OF PATHOLOGY 187 12: 2659-2673. 2017
• Lindgren A, Anttila M, Rautiainen S, Arponen O, Kivelä A, Mäkinen P, Härmä K, Hämäläinen K, Kosma V-M, Ylä-Herttuala S, Vanninen R, Sallinen H. 2017. Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI EUROPEAN RADIOLOGY 27 9: 4002-4012. 2017
• van Lith, SAM; van den Brand, D; Wallbrecher, R; Wübbeke, L; van Duijnhoven, SMJ; Mäkinen, PI; Hoogstad-van, Evert JS; Massuger, L; Ylä-Herttuala, S; Brock, R; Leenders, WPJ. 2017. The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2018; 124: 63-72. 2017
• Wennink JWH, Liu Y, Mäkinen PI, Setaro F, de la Escosura A, Bourajjaj M, Lappalainen JP, Holappa LP, van den Dikkenberg JB, Al Fartousi M, Trohopoulos PN, Ylä-Herttuala S, Torres T, Hennink WE, van Nostrum CF. 2017. Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 107: 112-125. 2017
• van Lith SA, Roodink I, Verhoeff JJ, Mäkinen PI, Lappalainen JP, Ylä-Herttuala S, Raats J, van Wijk E, Roepman R, Letteboer SJ, Verrijp K, Leenders WP. 2016. In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued. Oncotarget 7 44: 71594-71607. 2016
• Babu Mohan, Durga Devi Thota, Mäkinen Petri, Kaikkonen Minna, Lesch Hanna P, Junttila Sini, Laiho Asta, Ghimire Bishwa, Gyenesei Attila, Ylä-Herttuala Seppo. 2015. Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study. CIRCULATION RESEARCH [ONLINE: HTTP://CIRCRES.AHAJOURNALS.ORG/] 117: 289-299. 2015
• Heinonen SE, Kivelä AM, Huusko J, Dijkstra MH, Gurzeler E, Mäkinen PI, Leppänen P, Olkkonen VM, Eriksson U, Jauhiainen M, Ylä-Herttuala S.. 2013. The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models. CARDIOVASCULAR RESEARCH 99 4: 716-23. 2013
• Mäkinen PI, Ylä-Herttuala S. 2013. Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis. CURRENT OPINION IN LIPIDOLOGY 2013 Apr;24(2): 116-22. 2013
• Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A. 2013. Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase. AMINO ACIDS 2013 Jul 9. [Epub ahead of print]: -. 2013
• Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. 2013. The absence of macrophage Nrf2 promotes early atherogenesis. CARDIOVASCULAR RESEARCH 2013 Apr 1;98(1): 107-15. 2013
• Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. 2011. Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice. CARDIOVASCULAR DIABETOLOGY [ONLINE: HTTP://WWW.CARDIAB.COM/] 10: 1-12. 2011
• Mäkinen Petri. 2011. The role of macrophage scavenger receptors and endothelial lipase in atherosclerosis. Publications of the University of Eastern Finland. Dissertations in Health Sciences 67. 2011
• Kivelä AM, Mäkinen PI, Jyrkkänen HK, Mella-Aho E, Xia Y, Kansanen E, Leinonen H, Verma IM, Ylä-Herttuala S & Levonen AL. 2010. Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. ATHEROSCLEROSIS 213: 122-128. 2010
• Mäkinen PI, Lappalainen JP, Heinonen SE, Leppänen P, Lähteenvuo MT, Aarnio JV, Heikkilä J, Turunen MP & Ylä-Herttuala S. 2010. Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors CARDIOVASCULAR RESEARCH 88: 530-538. 2010
• Kärkkäinen A-M, Kotimaa A, Huusko J, Kholova I, Heinonen SE, Stefanska A, Dijkstra MH, Purhonen H, Hämäläinen E, Mäkinen PI, Turunen MP, Ylä-Herttuala S. 2009. Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation. BLOOD 113: 4468-4475. 2009
• Huusko J, Mäkinen PI, Alhonen L, Ylä-Herttuala S. 2008. Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques: Latterich M, RNAi.Taylor & Francis. 91-111. 2008
• The Second Annual Post-Graduate Symposium of the Graduate School of Molecular Medicine. Winter School 2008 Abstracts. Keinänen R, Hakkarainen M, Heikkinen R, Kallio P, Miettinen P, Mäkinen P, Purhonen H. 2008 2008
• Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain. JOURNAL OF GENE MEDICINE 8 4: 433-441. 2006