Petri Mäkinen

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Kaarijärvi, Roosa; Kaljunen, Heidi; Nappi, Lucia; Fazli, Ladan; Kung, Sonia H. Y.; Hartikainen, Jaana M.; Paakinaho, Ville; Capra, Janne; Rilla, Kirsi; Malinen, Marjo; Mäkinen, Petri I.; Ylä-Herttuala, Seppo; Zoubeidi, Amina; Wang, Yuzhuo; Gleave, Martin E.; Hiltunen, Mikko; Ketola, Kirsi. 2024. Communications biology. 7: . 108 A1 Journal article (refereed), original research

Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials and Challenges

Hosseini, Seyed Younes; Mallick, Rahul; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2024. Human gene therapy. 35: 577-776 A1 Journal article (refereed), original research

Navigating the prime editing strategy to treat cardiovascular genetic disorders in transforming heart health

Hosseini, Seyed Younes; Mallick, Rahul; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2024. Expert review of cardiovascular therapy. 22: 75-89 A2 Review article, Literature review, Systematic review

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

Deen, Ashik Jawahar; Adinolfi, Simone; Härkönen, Jouni; Patinen, Tommi; Liu, Xiaonan; Laitinen, Tuomo; Takabe, Piia; Kainulainen, Kirsi; Pasonen-Seppänen, Sanna; Gawriyski, Lisa M; Arasu, Uma Thanigai; Selvarajan, Ilakya; Mäkinen, Petri; Laitinen, Hanna; Kansanen, Emilia; Kaikkonen, Minna U; Poso, Antti; Varjosalo, Markku; Levonen, Anna-Liisa. 2024. Redox biology. 69: A1 Journal article (refereed), original research

SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer

Leppänen, Noora; Kaljunen, Heidi; Takala, Eerika; Kaarijärvi, Roosa; Mäkinen, Petri I; Ylä-Herttuala, Seppo; Paatero, Ilkka; Paakinaho, Ville; Ketola, Kirsi. 2024. Nucleic acids research. 52: 5610-5623 A1 Journal article (refereed), original research

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci, Giuseppe; Sukhavasi, Katyayani; Örd, Tiit; Bankier, Sean; Singha, Prosanta; Arasu, Uma Thanigai; Agbabiaje, Olayinka Oluwasegun; Mäkinen, Petri; Ma, Lijiang; Hodonsky, Chani J; Aherrahrou, Redouane; Muhl, Lars; Liu, Jianping; Gustafsson, Sonja; Byandelger, Byambajav; Wang, Ying; Koplev, Simon; Lendahl, Urban; Owens, Gary; Leeper, Nicholas J; Pasterkamp, Gerard; Vanlandewijck, Michael; Michoel, Tom; Ruusalepp, Arno; Hao, Ke; Ylä-Herttuala, Seppo; Väli, Marika; Järve, Heli; Mokry, Michal; C. 2024. Circulation research. 134: 1405-1423 A1 Journal article (refereed), original research

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

Scoyni, Flavia; Giudice, Luca; Väänänen, Mari Anna; Downes, Nicholas; Korhonen, Paula; Choo, Xin Yi; Välimäki, Nelli Noora; Mäkinen, Petri; Korvenlaita, Nea; Rozemuller, Annemieke J; de Vries, Helga E; Polo, Jose; Turunen, Tiia A; Ylä-Herttuala, Seppo; Hansen, Thomas B; Grubman, Alexandra; Kaikkonen, Minna U; Malm, Tarja. 2023. Alzheimer's & dementia. 2024; 20: 954-974 A1 Journal article (refereed), original research

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Babu, Mohan; Devi, Durga; Mäkinen, Petri; Örd, Tiit; Aavik, Einari; Kaikkonen, Minna; Ylä-Herttuala, Seppo. 2023. Arteriosclerosis, thrombosis, and vascular biology. 43: e46–e61 A1 Journal article (refereed), original research

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Freitag, Tobias L; Fagerlund, Riku; Karam, Nihay Laham; Leppänen, Veli-Matti; Ugurlu, Hasan; Kant, Ravi; Mäkinen, Petri; Tawfek, Ahmed; Kumar, Sawan; Strandin, Tomas; Leskinen, Katarzyna; Hepojoki, Jussi; Kesti, Tapio; Kareinen, Lauri; Kuivanen, Suvi; Koivulehto, Emma; Sormunen, Aino; Laidinen, Svetlana; Khattab, Ayman; Saavalainen, Päivi; Meri, Seppo; Kipar, Anja; Sironen, Tarja; Vapalahti, Olli; Alitalo, Kari; Ylä-Herttuala, Seppo; Saksela, Kalle. 2023. Vaccine. 41: 3233-3246 A1 Journal article (refereed), original research

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Končarević, Saša; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, . 2023. Neurobiology of disease. 182: A1 Journal article (refereed), original research

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Laitinen, Pia; Väänänen, Mari-Anna; Kolari, Ida-Liisa; Mäkinen, Petri I.; Kaikkonen, Minna U.; Weinberg, Marc S.; Morris, Kevin V.; Korhonen, Paula; Malm, Tarja; Ylä-Herttuala, Seppo; Roberts, Thomas C.; Turunen, Mikko P.; Turunen, Tiia A.. 2022. PLoS ONE. 17: A1 Journal article (refereed), original research

Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model

Järveläinen, Niko; Halonen, Paavo; Nurro, Jussi; Hätinen, Olli-Pekka; Korpela, Henna; Mäkinen, Petri; Gan, Li-Ming; Fritsche-Danielson, Regina; Ylä-Herttuala, Seppo. 2021. Human gene therapy. 32: 1295-1307 A1 Journal article (refereed), original research

Novel RNAi-Based Therapies for Atherosclerosis

Ruotsalainen, Anna-Kaisa; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2021. Current atherosclerosis reports. 23: 45 A2 Review article, Literature review, Systematic review

Nucleic Acid-Based Therapies for Atherosclerosis

Mäkinen, P; Ruotsalainen, AK; Ylä-Herttuala, S. 2020. Current atherosclerosis reports. 22: 10 A2 Review article, Literature review, Systematic review

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

Mehtonen, Juha; Teppo, Susanna; Lahnalampi, Mari; Kokko, Aleksi; Kaukonen, Riina; Oksa, Laura; Bouvy-Liivrand, Maria; Malyukova, Alena; Mäkinen, Artturi; Laukkanen, Saara; Mäkinen, Petri I; Rounioja, Samuli; Ruusuvuori, Pekka; Sangfelt, Olle; Lund, Riikka; Lönnberg, Tapio; Lohi, Olli; Heinäniemi, Merja. 2020. Genome medicine. 12: Article number: 99 A1 Journal article (refereed), original research

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

Lähteenvuo, Johanna; Hätinen, Olli-Pekka; Kuivanen, Antti; Huusko, Jenni; Paananen, Jussi; Lähteenvuo, Markku; Nurro, Jussi; Hedman, Marja; Hartikainen, Juha; Laham-Karam, Nihay; Mäkinen, Petri; Räsänen, Markus; Alitalo, Kari; Rosenzweig, Anthony; Ylä-Herttuala, Seppo. 2020. Molecular therapy. 28: 1-10 A1 Journal article (refereed), original research

Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers

Setaro, Francesca; Wennink, Jos W H; Mäkinen, Petri I; Holappa, Lari; Trohopoulus, Panagiotis N; Ylä-Herttuala, Seppo; van Nostrum, Cornelus F; De la Escosura, Andres; Torres, Tomás. 2019. Journal of materials chemistry. b. 2020; 8: 282-289 A1 Journal article (refereed), original research

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23 A1 Journal article (refereed), original research

Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

Banerjee, Shubhadeep; Sengupta, Jayeeta; Aljarilla, Ana; Setaro, Francesca; Mäkinen, Petri I; Wu, LinPing; Holappa, Lari; de la Escosura, Andres; Martinelli, Chiara; Trohopoulos, Panagiotis N; Ylä-Herttuala, Seppo; Urbanics, Rudolf; Szebeni, Janos; Torres, Tomas; Krol, Silke. 2019. Precision nanomedicine. 2: 278-302 A1 Journal article (refereed), original research

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Merentie, Mari; Rissanen, Riina; Lottonen-Raikaslehto, Line; Huusko, Jenni; Gurzeler, Erika; Turunen, Mikko P; Holappa, Lari; Mäkinen, Petri; Ylä-Herttuala, Seppo. 2018. PLoS ONE. 13: e0190981 A1 Journal article (refereed), original research

Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules

Belt, H; Koponen, JK; Kekarainen, T; Puttonen, KA; Mäkinen, PI; Niskanen, H;, Oja, J; Wirth, G; Koistinaho, J; Kaikkonen, MU; Ylä-Herttuala, S. 2018. Frontiers in cardiovascular medicine. 5: 16 A1 Journal article (refereed), original research

Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation

Durga Devi T, Babu M, Mäkinen P, Kaikkonen M, Heinaniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N,Tavi P, Ylä-Herttuala S. 2017. American journal of pathology. 187: 2659-2673 A1 Journal article (refereed), original research

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases

Wennink JWH, Liu Y, Mäkinen PI, Setaro F, de la Escosura A, Bourajjaj M, Lappalainen JP, Holappa LP, van den Dikkenberg JB, Al Fartousi M, Trohopoulos PN, Ylä-Herttuala S, Torres T, Hennink WE, van Nostrum CF. 2017. European journal of pharmaceutical sciences. 107: 112-125 A1 Journal article (refereed), original research

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

Lindgren A, Anttila M, Rautiainen S, Arponen O, Kivelä A, Mäkinen P, Härmä K, Hämäläinen K, Kosma V-M, Ylä-Herttuala S, Vanninen R, Sallinen H. 2017. European radiology. 27: 4002-4012 A1 Journal article (refereed), original research

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates

van Lith, SAM; van den Brand, D; Wallbrecher, R; Wübbeke, L; van Duijnhoven, SMJ; Mäkinen, PI; Hoogstad-van, Evert JS; Massuger, L; Ylä-Herttuala, S; Brock, R; Leenders, WPJ. 2017. European journal of pharmaceutics and biopharmaceutics. 2018; 124: 63-72 A1 Journal article (refereed), original research

In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

van Lith SA, Roodink I, Verhoeff JJ, Mäkinen PI, Lappalainen JP, Ylä-Herttuala S, Raats J, van Wijk E, Roepman R, Letteboer SJ, Verrijp K, Leenders WP. 2016. Oncotarget. 7: 71594-71607 A1 Journal article (refereed), original research

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study

Babu Mohan, Durga Devi Thota, Mäkinen Petri, Kaikkonen Minna, Lesch Hanna P, Junttila Sini, Laiho Asta, Ghimire Bishwa, Gyenesei Attila, Ylä-Herttuala Seppo. 2015. Circulation research. 117: 289-299 A1 Journal article (refereed), original research

Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase

Pirnes-Karhu S, Mäntymaa P, Sironen R, Mäkinen PI, Wojciechowski S, Juutinen S, Koistinaho J, Hörkkö S, Jantunen E, Alhonen L, Uimari A. 2013. Amino acids. 2013 Jul 9. [Epub ahead of print]: - A1 Journal article (refereed), original research

The absence of macrophage Nrf2 promotes early atherogenesis

Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. 2013. Cardiovascular research. : 107-15 A1 Journal article (refereed), original research

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models

Heinonen SE, Kivelä AM, Huusko J, Dijkstra MH, Gurzeler E, Mäkinen PI, Leppänen P, Olkkonen VM, Eriksson U, Jauhiainen M, Ylä-Herttuala S.. 2013. Cardiovascular research. 99: 716-23 A1 Journal article (refereed), original research

Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis

Mäkinen PI, Ylä-Herttuala S. 2013. Current opinion in lipidology. 2013 Apr;24(2): 116-22 A1 Journal article (refereed), original research

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

Heinonen Suvi E, Merentie Mari, Hedman Marja, Mäkinen Petri I, Loponen Elina, Kholová Ivana, Bosch Fatima, Laakso Markku, Ylä-Herttuala Seppo. 2011. Cardiovascular diabetology. 10: 1-12 A1 Journal article (refereed), original research

The role of macrophage scavenger receptors and endothelial lipase in atherosclerosis

Mäkinen Petri. 2011. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article)

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

Mäkinen PI, Lappalainen JP, Heinonen SE, Leppänen P, Lähteenvuo MT, Aarnio JV, Heikkilä J, Turunen MP & Ylä-Herttuala S. 2010. Cardiovascular research. 88: 530-538 A1 Journal article (refereed), original research

Sulforaphane inhibits endothelial lipase expression through NF-&#954 B in endothelial cells

Kivelä AM, Mäkinen PI, Jyrkkänen HK, Mella-Aho E, Xia Y, Kansanen E, Leinonen H, Verma IM, Ylä-Herttuala S & Levonen AL. 2010. Atherosclerosis. 213: 122-128 A1 Journal article (refereed), original research

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

Kärkkäinen A-M, Kotimaa A, Huusko J, Kholova I, Heinonen SE, Stefanska A, Dijkstra MH, Purhonen H, Hämäläinen E, Mäkinen PI, Turunen MP, Ylä-Herttuala S. 2009. Blood. 113: 4468-4475 A1 Journal article (refereed), original research

Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques

Huusko J, Mäkinen PI, Alhonen L, Ylä-Herttuala S. Teoksessa: Latterich M(toim.) , 2008. RNAi. s. 91-111. Taylor & Francis A3 Book section, Chapters in research books

The Second Annual Post-Graduate Symposium of the Graduate School of Molecular Medicine. Winter School 2008 Abstracts

Keinänen R, Hakkarainen M, Heikkinen R, Kallio P, Miettinen P, Mäkinen P, Purhonen H. 2008. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. . - C2 Edited book, conference proceedings or special issue of a journal

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen PI, Koponen JK, Kärkkäinen A-M, Malm TM, Pulkkinen KH, Koistinaho J, Turunen MP, Ylä-Herttuala S. 2006. Journal of gene medicine. 8: 433-441 A1 Journal article (refereed), original research

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Research groups

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Insights into Prime Editing Technology: A Deep Dive into Fundamentals, Potentials and Challenges

Navigating the prime editing strategy to treat cardiovascular genetic disorders in transforming heart health

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs

ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model

Novel RNAi-Based Therapies for Atherosclerosis

Nucleic Acid-Based Therapies for Atherosclerosis

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

Amphiphilic Phthalocyanines in Polymeric Micelles: A Supramolecular Approach toward Efficient Third-Generation Photosensitizers

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules

Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles : a possible treatment for cardiovascular diseases

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates

In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation Study

Enhanced polyamine catabolism disturbs hematopoietic lineage commitment and leads to a myeloproliferative disease in mice overexpressing spermidine/spermine N 1-acetyltransferase

The absence of macrophage Nrf2 promotes early atherogenesis

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models

Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

The role of macrophage scavenger receptors and endothelial lipase in atherosclerosis

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

Sulforaphane inhibits endothelial lipase expression through NF-&#954 B in endothelial cells

Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques

The Second Annual Post-Graduate Symposium of the Graduate School of Molecular Medicine. Winter School 2008 Abstracts

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain