I act as academy research fellow and research group leader in the Institute of Biomedicine at University of Eastern Finland. My research focuses on deciphering how nuclear protein interactions alter the regulation of genes in prostate cancer, and how these changes lead to the development of drug-resistant cancer. In addition to prostate cancer, I investigate the activity, interactions, and alteration of these proteins also in other disease states. More detailed description of my research can be found at our research group page (Paakinaho lab).
Research groups
Academic degrees and positions
-
2021 Title of a Docent (in the field of molecular endocrinology) (equivalent of Adjunct professor), University of Eastern Finland
2014 PhD (medical biochemistry), University of Eastern Finland
-
Current positions
2023 Assistant Professor (tenure track), Institute of Biomedicine, UEF
2021 Academy Research Fellow, Institute of Biomedicine, UEF
Past positions
2019, Special Volunteer, National Cancer Institute, NIH, USA
2018 – 2021, Postdoctoral Fellow (Academy of Finland), Institute of Biomedicine, UEF
2015 – 2017, Postdoctoral Fellow, National Cancer Institute, NIH, USA
2010 – 2014, Early Stage Researcher, Institute of Biomedicine, UEF
Teaching activities and positions of trust
-
Current teaching activities
Since 2023
Course organizer: Cancer Journal Club, Postgraduate studies, University of Eastern Finland
Since 2018
Course director: Genome-wide gene expression project (GEP), Master’s program in Biomedicine, University of Eastern Finland
Past teaching activities
2014
Lecturer: Johdatus bioinformatiikkaan (JOBI), Health bioscience degree programme, University of Eastern Finland
Laboratory instructor: Advanced laboratory works in molecular biology (ALMB), Health bioscience degree programme, University of Eastern Finland
2013
Laboratory instructor: Molekyylibiologian laboratoriotyöt biokemisteille (BIK390), Bioscience degree programme, University of Eastern Finland
Laboratory instructor: Lääketieteellinen biokemia 2 (LBK2), Medical degree programme, University of Eastern Finland
2012
Laboratory instructor: Molekyylibiologian laboratoriotyöt biokemisteille (BIK390), Bioscience degree programme, University of Eastern Finland
2011
Laboratory instructor: Lääketieteellinen biokemia 2 (LBK2), Medical degree programme, University of Eastern Finland
-
Since 2023
Member of the steering group, The Multidisciplinary Cancer Research community, University of Eastern Finland
Since 2022
Member of the executive committee, The Finnish Endocrine Society
Honours
-
2022, Unto Uotila Award (Young Investigator Award), Finnish Endocrine Society, Finland
2019, The Endocrine Society Outstanding Abstract Award, Endocrine Society, United States
2017, The Fellows Award for Research Excellence (FARE), NIH, United States
2015, Young Researcher Award, UEF, Finland
Links
Publications
11 items-
Fanconi anemia pathway regulation by FANCI in prostate cancer
Kaljunen, Heidi; Taavitsainen, Sinja; Kaarijärvi, Roosa; Takala, Eerika; Paakinaho, Ville; Nykter, Matti; Bova, G Steven; Ketola, Kirsi. 2023. Frontiers in oncology. 13: . 1260826 -
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Garcia, David A; Johnson, Thomas A; Presman, Diego M; Fettweis, Gregory; Wagh, Kaustubh; Rinaldi, Lorenzo; Stavreva, Diana A; Paakinaho, Ville; Jensen, Rikke AM; Mandrup, Susanne; Upadhyaya, Arpita; Hager, Gordon L. 2021. Molecular cell. 81: 1484-1498 -
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579 -
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Vandewalle, Jolien; Timmermans, Steven; Paakinaho, Ville; Vancraeynest, Lies; Dewyse, Liza; Vanderhaeghen, Tineke; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Eggermont, Melanie; Dewaele, Sylviane; Velho, Tiago R; Moita, Luis F; Weis, Sebastian; Sponholz, Christoph; van Grunsven, Leo A; Dewerchin, Mieke; Carmeliet, Peter; De Bosscher, Karolien; et al.; [incl. Palvimo, Jorma]. 2021. Cell metabolism. 33: 1763-1776.e5 -
Genome-wide binding potential and regulatory activity of the glucocorticoid receptor's monomeric and dimeric forms
Johnson, Thomas A; Paakinaho, Ville; Kim, Sohyoung; Hager, Gordon L; Presman, Diego M. 2021. Nature communications. 12: 1987 -
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
Paakinaho, Ville; Palvimo, Jorma J. 2021. Endocrine-related cancer. 28: R231-R250 -
Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model
Garcia, David A; Fettweis, Gregory; Presman, Diego M; Paakinaho, Ville; Jarzynski, Christopher; Upadhyaya, Arpita; Hager, Gordon L. 2021. Nucleic acids research. 49: 6605-6620 -
Reprogramming of glucocorticoid receptor function by hypoxia
Vanderhaeghen, Tineke; Timmermans, Steven; Watts, Deepika; Paakinaho, Ville; Eggermont, Melanie; Vandewalle, Jolien; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Dewaele, Sylviane; Vanden Berghe, Joke; Lemeire, Kelly; De Backer, Joey; Dirkx, Laura; Vanden Berghe, Wim; Caljon, Guy; Ghesquière, Bart; De Bosscher, Karolien; Wielockx, Ben et al [incl. Palvimo, Jorma J]. 2021. Embo reports. 2022; 23: e53083 -
SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. Nucleic acids research. 49: 1951-1971 -
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome
Paakinaho, V; Johnson, TA; Presman, DM; Hager, GL. 2019. Genome research. 29: 1223-1234